CN102552645B - Kidney-tonifying and yang-strengthening health-care medicament and preparation method thereof - Google Patents
Kidney-tonifying and yang-strengthening health-care medicament and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kidney-tonifying and yang-strengthening health-care medicament and a formula thereof, and relates to the field of medicaments. The medicament is prepared by combination of the following components: 6 to 10g of leek extract, 4 to 9g of morinda officinalis, 4 to 9g of cordyceps sinensis, 6 to 12g of cistanche, 4 to 9g of ginseng, 3 to 8g of beta-cyclodextrin, 4 to 10g of pregelatinized starch, 3 to 8g of microcrystalline cellulose, 6 to 15g of powdered sugar, and 0.3 to 1g of magnesium stearate. The preparation process comprises the following steps: respectively crushing the morinda officinalis, the cordyceps sinensis, the cistanche and the ginseng; screening through a 60 to 80-mesh screen; weighing the crushed medicinal powder and other raw and auxiliary materials, and mixing for 45 to 50 minutes; filling into capsules, and controlling the weight of powdered medicaments according to an inner quality standard; separating, polishing, internally packaging and externally packaging; and inspecting according to the inspection standard and putting in a warehouse. The medicament helps people enhancing immunity, relieving physical fatigue and tonifying kidney and strengthening yang, so that the living level of people is improved, the living quality of people is increased, and side effect or adverse reactions cannot be generated; and the product is safe and stable and has controllable quality by using modern preparation technology and advanced quality control method.
Description
Technical field:
The present invention relates to drug world, be specifically related to a kind of kidney supplementing yang invigorating health care medicine and preparation method thereof.
Background technology:
Sexual disorder is the physiological phenomenon of a kind of complexity of human body, is the result of multifactor functioning.A large amount of research makes people exhaust or the metabolite accumulation from simple material for the understanding of immunity, is deep into gradually cell, subcellular fraction and even molecular level.
Along with the quickening of modern life rhythm, the aggravation of social competition, hypoimmunity more and more becomes a lot of people's of puzzlement health problem, causes that because of hypoimmunity the crowd of disease also increases gradually, and will be in ascendant trend always.Simultaneously, along with growth in the living standard, health perception also strengthens gradually, and the health product with enhancing immunity have the very large market space.
Summary of the invention:
The prescription that the purpose of this invention is to provide a kind of kidney supplementing yang invigorating health care medicine, it can improve people's sexual function, to diseases such as treatment sexual impotence, premature ejaculation, therapeutical effect is arranged, and has simultaneously the vigor that strengthens the human body surface cell, suppresses the old and feeble effect that waits.
In order to solve the existing problem of background technology, the present invention is by the following technical solutions: a kind of kidney supplementing yang invigorating health care medicine, leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
The first preferred implementation of this medicine is: leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
The second preferred implementation of this medicine is that recipe ratio is leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
The 3rd preferred implementation of this medicine is, recipe ratio is leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
The effective ingredient of leek extract is nucleoside, the effective ingredient of Radix Morindae Officinalis extract is the Radix Morindae Officinalis element, the effective ingredient of Cordyceps is Paecilomyces hepiali Chen et Dai Mycelia, the effective ingredient of Herba Cistanches extract is the Herba Cistanches element, the effective ingredient of Radix Ginseng extract is the ginsenoside, and the effective ingredient of beta-schardinger dextrin-is pregelatinized Starch.
The effective ingredient ratio of this medicine is preferably: the 100g medicine contains effective composition nucleoside 1200mg, Radix Morindae Officinalis element 4000mg, Paecilomyces hepiali Chen et Dai Mycelia 700mg, Herba Cistanches element 4500mg, ginsenoside 2000mg.
The preparation method of this medicine is: first Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng are pulverized respectively, cross the 60-80 mesh sieve, various drug powders and other supplementary material after weighing is pulverized mix, incorporation time control 45-50 minute, then carry out capsule-filling, filling process is filled the weight of medicated powder according to inner quality standard control, selects, polishing, inner packing, outer package, preferably according to touchstone check warehouse-in again.
The present invention's energy kidney invigorating and YANG supporting can improve people's sexuality, to controlling sexual impotence, Patients with Premature Ejaculation therapeutical effect.
The specific embodiment:
This specific embodiment is by the following technical solutions: the recipe ratio of this medicine is leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
The first preferred implementation of this medicine is that recipe ratio is leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
The second preferred implementation of this medicine is that recipe ratio is leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
The 3rd preferred implementation of this medicine is, recipe ratio is leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
The effective ingredient of leek extract is nucleoside, the effective ingredient of Radix Morindae Officinalis extract is the Radix Morindae Officinalis element, the effective ingredient of Cordyceps is Paecilomyces hepiali Chen et Dai Mycelia, the effective ingredient of Herba Cistanches extract is the Herba Cistanches element, the effective ingredient of Radix Ginseng extract is the ginsenoside, and the effective ingredient of beta-schardinger dextrin-is pregelatinized Starch.
The effective ingredient ratio of this medicine is preferably: the 100g medicine contains effective composition nucleoside 1200mg, Radix Morindae Officinalis element 4000mg, Paecilomyces hepiali Chen et Dai Mycelia 700mg, Herba Cistanches element 4500mg, ginsenoside 2000mg.
The preparation method of this medicine is: first Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng are pulverized respectively, cross the 60-80 mesh sieve, various drug powders and other supplementary material after weighing is pulverized mix, incorporation time control 45-50 minute, then carry out capsule-filling, filling process is filled the weight of medicated powder according to inner quality standard control, selects, polishing, inner packing, outer package, preferably according to touchstone check warehouse-in again.
The present invention's energy kidney invigorating and YANG supporting improves people's sexual function, to controlling sexual impotence, Patients with Premature Ejaculation therapeutical effect.
Leek extract:
Leek seed and root all can be used as medicine, and seed is warm in nature, acrid in the mouth, salty, enter liver, kidney channel, that chews pungently has a Folium Allii tuberosi flavor, contains alkaloid and saponin, can invigorating the liver and kidney, warm waist knee joint, Xing Yangdao controls sexual impotence controlling nocturnal emission with astringent drugs and married woman's YIN-cold, lower abdomen pain, be the strong waist medicine of excitement of Bu Shen Zhuang waist, can be used for treating the diseases such as seminal emission, premature ejaculation, sexual impotence and polyuria.According to the pharmacopeia record, leek seed has the effect of " temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs ", and the fragrant-flowered garlic seed is used as strengthening yang and invigorating kidney and is used as medicine in China's history among the people existing thousands of years.
According to the pharmacopeia record, leek seed has the effect of " temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs ", and with being used as medicine in China's existing thousands of years history among the people, China's Ministry of Public Health was classified it as medicine food dual purpose plant natural product to the fragrant-flowered garlic seed in 2002 as strengthening yang and invigorating kidney.In the Allium tubersum rottl extract there be main component: tabacin, β 2 daucosterols contain ribosidoadenine, thymidine especially, for Folium Allii tuberosi provides support on the experimental data as the development and use of flavoring agent and health product.Ma Qingchen, Lv Wenhua, " experimentation of Chinese chive seed oil high temperature resistance and anti-cold service " literary composition that Li Tingli etc. deliver at 2000 " Chinese medicine journal " shows that the concentration by 0.01% adds Chinese chive seed oil in culture medium, just birth, the fruit bat etherization of copulation not, male and female separately, put into respectively the test tube of blank group and administration group, 25 of every pipes.Raise after 3 days, fruit bat is all changed in the empty test tube that does not add culture medium, put into 30min in the constant incubator of (304-2) ℃, take out, observe the maimed situation of fruit bat and calculate mortality rate, the result shows that administration group fruit bat mortality rate is starkly lower than matched group, has utmost point significant difference between the two; Substantially identical with the high temperature resistance experiment in experimentation, administration concentration, different is that fruit bat was raised after 3 days, after changing in the empty test tube that does not have culture medium, placing 50rain in one 10 ℃ of refrigerators takes out, observe death condition, and the calculating mortality rate, leek seed line of oils fruit bat mortality rate is starkly lower than the blank group, has utmost point significant difference between the two; The experimental group fruit bat that gives leek seed thought in article, and under high and low temperature stimulated, mortality rate all was lower than the blank group, and thisly act on that difference does not illustrate very much on the sex, and leek seed has the effect of enhancing body nonspecific resistance.
Zhou Haoquan etc. deliver in " deoxythymidine and theophylline are to the preliminary study of mouse asthmatic immunoregulation effect " literary composition and find at " Anhui medicine ", the a large amount of LC of matter infiltrate between around thymidine intervention group first all air flue tube walls, the air flue chamber is narrow, alveolar septum broadening, LC in the alveolar space, EOS and macrophage ooze out more, BALF cytolgical examination Ams ratio also significantly raises, IFN2 γ is significantly higher than asthma group and theophylline group among the BALF at this moment, spleen pathology first, the second week white pulp is that moderate enlarges, LC hyperplasia, macrophage increases in the red pulp, show that thymidine may be by promoting LC and macrophage hypertrophy, increase the secretion of IFN2 γ, thereby antagonism pulmonary allergic inflammation is replied the Th2 advantage of asthma and has been obtained partly correcting.Other immunostimulant is applied to asthma, similar effect is also arranged, such as BCG.We once used adenosine as intervention factor, reduced lung tissue LC and infiltrated and pathological change, obtained obvious effect.
In the warming the kidney to activate YANG effect of the Semen Allii Tuberosi extract " research " literary composition that Anhui Chinese Medicine College king Cheng Yong etc. delivered in 13 phases of the 30th volume in July, 2005 " CHINA JOURNAL OF CHINESE MATERIA MEDICA " mice suffered from a deficiency of the kidney and the research of yang deficiency as follows:
1. on the impact of nephrasthenia syndrome model
The Wistar rat carries out two sorrowful orchiectomys under pentobarbital sodium anesthesia, postoperative is intramuscular injection penicillin sodium 20,000 u/kg for three days on end, the administration of then dividing into groups.(1) sham operated rats is all given the equivalent solvent with (2) model group.(3)-(5) Semen Allii Tuberosi ethanol extract group, dosage is respectively 10g/kg, 20g/kg, 40g/kg; (6) androlin group.Except (6) group is the subcutaneous injection administration, all the other respectively organize equal ig administration, every day 1 time, continuous 20 days, then give the local electrical stimulation of 4mA with the multiplex instrument of SD-4 type pharmacology physiology (Bangbu radio two factories) at rat penis position, the record animal erects incubation period, and (second, S), the result organizes a t check.
Table 1 Allium tubersum rottl extract on the impact of castrated rats eclipse period of penile erection (n=8,
)
| Group | Dosage (g/kg) | Eclipse period of penile erection (s) |
| Sham operated rats | ? | 18.7±9.4 |
| Model group | ? | 32.5±17.3 |
| The androlin group | 0.002 | 19.0±6.4** |
| The Allium tubersum rottl extract group | 40 | 21.3±7.9** |
| The Allium tubersum rottl extract group | 20 | 25.3±14.8* |
| The Allium tubersum rottl extract group | 10 | 29.9±18.5 |
Annotate: compare * P＜0.05, * * P＜0.01 with model group
As shown in Table 1, Semen Allii Tuberosi extract (at 20g/kg, under the 40g/kg dosage) can improve the castrated rats penis to the irritability of electricity irritation, shortens eclipse period of penile erection.
2. on the impact of yang deficiency syndrome animal model
Male mice in kunming is divided into 5 groups, 10 every group, is respectively the large, medium and small dosage group of normal group, model group and Semen Allii Tuberosi; Except normal group, all the other each groups all adopt for three days on end, and intramuscular injection hydrocortisone 0.25mg/10g causes syndrome of deficiency of kidney-YANG model [3], respectively organize successive administration 7 days 45 before the modeling, successive administration in the time of modeling, after administration in the 4th day after the modeling 1 hour, record each treated animal and make body weight, body temperature changing value before and after touching, the movable number of times of the freedom in 10 minutes, low temperature swimming (14 ± 1 ℃) time-to-live, the results are shown in Table 2.
Table 2 Allium tubersum rottl extract on the impact of syndrome of deficiency of kidney-YANG (n=8,
)
Annotate: compare * P＜0.01 with model group
Table 2 is the result show, Semen Allii Tuberosi extract can obviously prolong mice in the time-to-live of low temperature swimming, increases the autonomic activities number of times, delay the weight loss trend due to the hydrocortisone, increase the physiological function of animal body, improve its tolerance, illustrate that Semen Allii Tuberosi extract has certain supporing yang effect.The effect that has the enhancing body nonspecific resistance with the Semen Allii Tuberosi of bibliographical information is consistent.
Leek seed is classified as the medicine food dual purpose plant natural product by China's Ministry of Public Health.Long period proves through China, and leek seed does not have the toxicity side effect.Originally declare every of product and contain the 140mg Allium tubersum rottl extract, take 2 every day, be equivalent to edible Allium tubersum rottl extract 280mg every day, 4.0g makes by leek seed, is equivalent to edible leek seed 4.0g every day.Take 5～15g the every day that is lower than 2010 editions pharmacopeia regulation.
Radix Ginseng:
Radix Ginseng extract in the prescription take China's Radix Ginseng as raw material the production technology through the advanced person make.Radix Ginseng is included in " Ministry of Public Health is about the notice of further standard healthy food material management " adnexa 2 and be can be used for the article list of health food.The more bibliographical information of Radix Ginseng Radix Ginseng have the enhancing immunity function, think such as the people such as Luo Yanqiu experiment conclusion in " research that the Folium Ginseng Saponin is regulated chicken immuological function " literary composition that " Agriculture of Anhui science " delivered: the Folium Ginseng Saponin can promote the generation of chicken body internal specific antibody and the phagocytic activity of activated mononuclear-macrophage system; Chu Xiuling thinks at " ginsenoside's immunomodulating and Studies On Antiviral Activities " literary composition that " Chinese veterinarian's medical magazine " delivered: the ginsenoside can promote the growth of Immune Organs of Body, thereby directly affects immunity of organisms; The ginsenoside also can affect the stages of hematopoietic cell CFU-GM and hematopoietic stem cell, thereby strengthens the function of immunocyte, improves the resistance of body; The rich people of grade of imperial court tests in " Ginsenoside Rg3 is on the impact of immunologic function " literary composition that " China Medicine University's journal " delivered and shows: Ginsenoside Rg3 can obviously improve mice carbon clearance speed, immune organ weight, serum hemolysin content, splenocyte transforms and NK is active, illustrates that Ginsenoside Rg3 has the effect of raising immunologic function; The people such as Ren Jiehong experimental result in " ginsenoside Rg1's immunologic enhancement " literary composition that " new Chinese medicine and clinical pharmacology " delivered shows: ginsenoside Rg1 can increase the weight of mouse immune organ and the phagocytic function of macrophage, improves the content of IL-2, complement C3, C4 in the rat blood serum.Illustrate that Rg1 can improve the laboratory animal immunity of organisms, play the effect that improves the body defense function, immunologic enhancement is namely arranged; The people such as Zhao Wenli show at " progress of ginsenoside's antifatigue effect " literary composition of delivering of the 20th phase the 5th volume " Chinese food health magazine " in 2008: the ginsenoside can produce by suppressing hydroxyl, oxygen-derived free radicals, the lipid peroxidation of hydrogen peroxide and the effect of accelerating the approach performance antioxidant radicals such as free radical scavenging, thereby reach the purpose of alleviating physical fatigue, the ginsenoside also has the effect that raising power exhausts ability and the enhances skeletal flesh SOD activity of postexercise recovery phase mice skeletal free radical resisting; Wang Ying, Cai Dong is associated in the ginseng effective component's Radix Ginseng total saponins (TSPG) that shows in " Advances of Research on Anti-Fatigue Effects of Panax ginseng " literary composition of delivering on " aminoacid and living resources " magazine with extracting, press various dose to the continuous gavage 7d of mice, measure the content of Mouse Blood Lactoferrin, the result shows, the gavage Radix Ginseng total saponins can increase the content of white mice hemoglobin, middle dosage group is the most obvious, increase by 6.6%, thereby can significantly increase the each degree of utilizing of breathing oxygen of mice, can increase Hb content in the erythrocyte by TSPG, and hemoglobin is the main molecules of transporting O2 and CO2 in the blood, content of hemoglobin increases and both is conducive to provide more oxygen to muscular tissue in strenuous exercise, strengthen the aerobic metabolism energy supply, lactic acid produces and reduces, accelerate simultaneously the removing of lactic acid, can also in time the CO2 that produces in the muscular tissue be transported to lung and discharge, avoid because the muscle fatigue that pH descends and causes.This has positive role to the generation of delayed motion fatigue and the elimination that accelerates fatigue; Huanghai Sea English is delivered in " ginsenoside's pharmacological action " literary composition in the 1st phase of the 2nd volume February in 2003 " the up-to-date medical information digest in the world " and is shown, from neural, endocrine angle, chronic fatigue syndrome is relevant with disaster class substance metabolism confusion, the Radix Panacis Quinquefolii ginsenoside feeds mice, Ldh Activity and hepatic glycogen content and matched group increase more to some extent behind the 15d, 20min behind the mouse movement behind the 29d, the serum lactate level of 5min not only is starkly lower than matched group, and is lower than this group test level.In addition, the ginsenoside can increase the content of myosin adenosinetriphosphataes, and is tired due to relieve chronic fetters.Studies show that the ginsenoside has regulated the confusion of the Monoamines of confirmed fatigue animal to a certain extent, this mechanism may be that Chinese medicine significantly improves one of the fatigue performance of confirmed fatigue animal and reason of ability of learning and memory; The people such as Feng Yi Chong deliver in the 2nd phase of the 40th volume April in 2009 " Fujian Chinese medicine " in " ginsenoside Re and Radix Ginseng total saponins are on sports fatigue rat hypothalamus Ach, DA, 5-HT and contain the impact that GABA measures " literary composition and show, the mensuration of sports fatigue rat model Hypothalamic Neurotransmitter acetylcholine, dopamine, 5-hydroxy tryptamine and alpha-aminobutyric acid content that the equicohesive treadmill exercise of centering copies, find that ginsenoside Re and Radix Ginseng total saponins all can effectively improve the content of acetylcholine and dopamine, reduce the content of 5-hydroxy tryptamine and γ-aminobutyric acid.Organize comparison with the ginsenoside Re, Radix Ginseng total saponins group rat hypothalamus Ach, 5-HT and GABA have significance to reduce, and DA content has significance to raise; China Ceng Meiyi, the Li Minmin of Academy of Traditional Chinese Medicine and Ministry of Public Health drug evaluation center Zhao Xiu literary composition " new Chinese medicine with face the window pharmacology " March in 1997 the 8th volume the 1st interim " the Radix Ginseng toxicologic study " delivered show: 1. BerteShi 1982) standardization Radix Ginseng journey cream c115 (the lower G115 of abbreviation) mixed feeds mice, rat and miniature pig (miniPig) rat, mice single oral dose in the feedstuff and be respectively 2000mg, 3000mg, 4000mg and 5000mg/kg, lumbar injection dosage is respectively 250mg, 500mg and 1000mg/kg, and the observation period is 14d.The oral GII5 LD10 of rat and mice all＞1000mg/kg.The oral chaste tree amount of miniature pig 2000mg/kg observes 7d.Record its body weight. detect hematology, blood biochemical numerical value, have no any toxic reaction; 2. Savel (1971) gives Oral Administration in Rats c115, and every daily dose is that hematology's detection and the organ histology microscopy behind the continuous 20d training of the 4000mg/kg. medicine is all normal; 3. 32 Beagle Canis familiaris L.s of HessShi etc. (1983) training are fed G115, and every daily dose is 0,1.5,5.0 and 15mg/kg. 90d when being.Investigated the absolute and relative weight of body weight, food ration, organ of animal; Hematology and blood biochemical are learned and are detected. be showed no any abnormal response that is produced by medicine.The histological examination of high dose group and control animals, the result also has no the toxic reaction relevant with medicine.Think that daily dose is that the G115 extractum of 15 milligrams/kg does not have chronic toxicity; Originally declare every of product and contain its content of ginsenoside of Radix Ginseng extract 185.5mg 37.1mg, be equivalent to edible Radix Ginseng extract 371mg every day, production yield 10% is equivalent to edible Radix Ginseng 3.71g every day, takes 3～9g the every day that meets 2010 editions pharmacopeia regulations.
Radix Morindae Officinalis
Radix Morindae Officinalis (MorindaofficinalisHow) is the Rubiaceae Rubia plants, and its fleshy tap root is one of China's four Da Nan medicines, has the effect of invigorating primordial QI, settling five organs, bone and muscle strengthening, strong waist, is the conventional Chinese medicine of warming the kidney to invigorate YANG.Rat is had weightening finish to Radix Morindae Officinalis decocting liquid and antifatigue effect I draws, and can significantly increase the white mice body weight, prolong lasting swimming time t61, improves the motor capacity on cat net, is reduced in the oxygen consumption under the anaerobic condition, prolongs the anoxia enduring persistent period.The researchs such as Pan Xinyu find that also Radix Morindae Officinalis can improve the function of motion rat free radical resisting oxidation, and the rat motor ability is obviously strengthened.Increasing the Radix Morindae Officinalis water decoction can improve serum superoxide dismutases (SOD) and glutathion peroxidase (GSH-Px) activity and reduce Serum MDA (MDA) content, think that Radix Morindae Officinalis can or promote body to produce the endogenous antioxidant by the supplemented with exogenous antioxidant, remove free radical, suppress lipid peroxidation injury, slow down aging 1121.Bar halberd element can improve aging rats model SOD and GSH-Px is active, observes simultaneously the content that bar halberd element can improve NO in its cerebral tissue, and the glucose level of rising cerebral tissue reduces lipid peroxide (LPO) and lipofuscin and generates and gather.Think that clinging to the halberd element may be that NO descends in the aging rats cerebral tissue by suppressing, improve the activity of Glucose Metabolism in Brain Tissues level and antioxidase, suppress lipid peroxidation and gathering of lipofuscin and an anti-aging effects.The Radix Morindae Officinalis water extract has obvious intervention effect to people's sperm peroxide injury due to the active oxygen, and the sperm motility function is had protective effect.The Radix Morindae Officinalis alcohol extract can increase Aging Male epididymal sperm sum, the sperm rate of living, reduce abnormal sperm rate, and resist significantly that sperm rate alive that Propranolol causes reduces and the rising of abnormal sperm rate, and these effects may to improve in the aging rats testis tissue SOD activity relevant with the Radix Morindae Officinalis alcohol extract.The Radix Morindae Officinalis ethanol extract can by acting on spermatogonium and primary spermatocyte, reduce the sperm basis abnormal rate of male white mouse.Bar halberd polysaccharide can improve fruit bat property vigor, and significantly improves the eclosion rate of fruit bat newborn larvae, thinks that bar halberd polysaccharide has obvious kidney invigorating and YANG supporting effect.
1, the Radix Morindae Officinalis oligosaccharide is on the impact of fruit bat property vigor:
Table 3 shows that the Radix Morindae Officinalis oligosaccharide can improve the property vigor of fruit bat, and fruit bat type copulation percentile rank is 3 groups＞2 groups＞1 group, and its effect is strong and weak to be proportionate with the Radix Morindae Officinalis concentration of oligosaccharide.The Radix Morindae Officinalis medical material does not affect fruit bat type copulation percentage rate when this experimental concentration; Positive control drug " NANBAO " can improve fruit bat type copulation percentage rate.
Table 3 Radix Morindae Officinalis oligosaccharide is on the impact of fruit bat property vigor
2, the Radix Morindae Officinalis oligosaccharide is on the impact of fruit bat eclosion rate:
Table 4 shows that the Radix Morindae Officinalis oligosaccharide can significantly improve the larva eclosion rate, with matched group relatively, its eclosion rate can improve 25.42%-35.39%, but along with the rising of Radix Morindae Officinalis concentration of oligosaccharide, the larva eclosion rate is slightly on a declining curve.Radix Morindae Officinalis medical material and NANBAO all can significantly improve the larva eclosion rate.
Table 4 Radix Morindae Officinalis oligosaccharide is on the impact of fruit bat eclosion rate
(1) under the used dosage of this test, the Radix Morindae Officinalis aqueous extract does not show the effect that fruit bat property vigor increases.Yet from Radix Morindae Officinalis, extract, separate the Radix Morindae Officinalis oligosaccharide that obtains and then improved fruit bat property vigor.Measurement result shows that used Radix Morindae Officinalis medical material oligosaccharide content is 13.87%, so medical material group concentration of oligosaccharide should be close with oligomeric group of Radix Morindae Officinalis.Thereby prompting, ' other contained compositions of Radix Morindae Officinalis medical material may disturb the Radix Morindae Officinalis oligosaccharide to improve the effect of fruit bat property vigor;
(2) because the experiment of fruit bat property vigor only can reflect fruit sexual intercourse distribution percentage in the short-term (11min), can not investigate Male Drosophila semen quality and long-time interior fruit bat number of copulations, therefore, the research contents of newborn larvae eclosion rate has been set up in this experiment, to remedy the deficiency of originality vigor experiment.Plumage Cordyceps
Cordyceps and Radix Ginseng, Cornu Cervi Pantotrichum are equally celebrated for their achievements, are one of Chinese medicine three essentials-essence, and be historical as medicine and the existing centuries of health product, by the extensive understanding and accepting of people institute.China is discovery and more remote at the medicinal history of pharmaceutically using Cordyceps country the earliest, particularly Periostracum cicadae and Cordyceps." Xinhua's book on Chinese herbal medicine outline " book begins to be stated from for the research of Cordyceps militaris (L.) Link. in China, puts down in writing its effect and is: " sweet in the mouth, property are put down, the effect of the lung benefiting the kidney invigorating is arranged, mending marrow, hemostasis and phlegm "." Chinese medicine sea " thinks its " meridian distribution of property and flavor, sweet, flat enters lung kidney two warps ", and its function has: (one) kidney tonifying YANG invigorating, and the sweet flat kidney-replenishing of this product, beneficial marrow is controlled deficiency of kidney yin, vertigo and tinnitus, forgetfully is insomnia, the disease such as soreness of the waist and knees, impotence and premature ejaculation; (2) not only kidney-replenishing but also tonifying the lung the moon are protected the lung kidney tonifying, and secret lean gas has good therapeutic effect to lung kidney deficiency, chronic cough dyspnea due to deficiency, phthisical cough expectorant blood person." national Chinese herbal medicine compilation " record: Cordyceps militaris (Cordyceps militaris (L.) Link.) sporophore also can be used as Cordyceps and is used as medicine.
1, the Cordyceps preparation is on the impact of yang deficiency mice:
1.1 the Cordyceps preparation is on the impact of yang deficiency syndrome mice low temperature swimming time: heavy dose of hydrocortisone can cause the mice yang deficiency syndrome, makes that mice is cold-resistant, fatigue resistance descends.Chinese caterpillar fungus preparation I and II can obviously postpone mice low temperature swimming time, and along with the prolongation of Time of Administration, the time-to-live of mice low temperature swimming also obviously prolongs, after taking 1 month, Chinese caterpillar fungus preparation I group low temperature swimming time prolongs 123.87s than yang deficiency group, and Chinese caterpillar fungus preparation II group prolongs 43.53s.The Cordyceps fermented liquid group also has certain prolongation, but effect is weaker than other two sample.See Table 5.
Table 5 Cordyceps preparation is on the impact (n=10) of yang deficiency syndrome animal
※ P＜0.01, each group contrasts with the yang deficiency group respectively
1.2 the Cordyceps preparation is on the impact of yang deficiency syndrome mice autonomic activities number: after feeding 30 days, yang deficiency syndrome mice autonomic activities number of times is starkly lower than Normal group, Cordyceps preparation I group mice autonomic activities number of times is than Duoing 7.8 times in the yang deficiency group 10min, Chinese caterpillar fungus preparation I group is than yang deficiency group activity 12.2 times often, and Chinese caterpillar fungus preparation II organizes many 9.2 times.Along with the prolongation of Time of Administration, successful.
1.3 the Cordyceps preparation is on the impact of yang deficiency syndrome Mouse Weight: after taking sample 15d, yang deficiency group Mouse Weight is starkly lower than normal group, and sample sets increases to some extent than yang deficiency group body weight, but not remarkable; After 1 month, 3 sample sets body weight are apparently higher than the yang deficiency group, and especially Chinese caterpillar fungus preparation II group effect is very obvious, and along with Time of Administration prolongs, effect is more obvious.
1.4 the Cordyceps preparation is putd question to impact to the yang deficiency syndrome mice: the body temperature of normal mouse is at 37-39 ℃, hydrocortisone has no significant effect the body temperature of mice, take the mouse temperature of Cordyceps fermented liquid and Chinese caterpillar fungus preparation group and compare without significant change with Normal group, yang deficiency group, visible sample is little on the mouse temperature impact.
1.5 the Cordyceps preparation is on the impact of yang deficiency mice androgen: yang deficiency group mice Serum Testosterone Levels acutely descends, and takes 3 kinds of samples after 1 month, the androgen of mice all increases to some extent, but still is lower than normal group.Take sample after 1.5 months, the androgen of 3 sample sets returns to the level of normal mouse, and wherein the Serum Testosterone Levels of Chinese caterpillar fungus preparation II group increases obviously, is significantly higher than normal group.
2, the Cordyceps preparation is on the impact of the animal of suffering from a deficiency of the kidney
2.1 the tonifying YANG experiment: the results are shown in Table 6. and take sample 30d, the eclipse period of penile erection of castrated rats namely returns to the time of normal rat, is significantly shorter than castration model group (P＜0.01).
Table 6 Cordyceps preparation is on the impact of castrated rats penile erectile function
※ P＜0.01 is compared with the castration model group.
1.6 the impact on the animal genitals weight of suffering from a deficiency of the kidney: each genitals's of the rat of suffering from a deficiency of the kidney (castrated rats) weight is starkly lower than normal rat.Take 3 kinds of samples after 30 days, the preputial glands of mice, levator ani and prostate add the weight of seminal fluid capsule apparently higher than the castration model group, and along with feeding time lengthening, weight also obviously increases, and wherein Chinese caterpillar fungus preparation I group effect is best.See Table 7.
Table 7 Cordyceps preparation is on the impact (n=8) of the animal of suffering from a deficiency of the kidney
Compare with each group respectively #P＜0.01, Normal group; ※ P＜0.01, castration model group are relatively
Xu Xi etc. says that in intraperitoneal injection (i.p) mode Cordyceps decocting in water alcohol extract 1-3g/ (kg.d) * 3 gives mice, can make its peripheral blood and splenic lymphocyte proliferation, particularly t helper cell propagation significantly, the TH/TS ratio raises, be the ability enhancing that splenocyte produces interleukin II (TL-2), and NKT (NK) cytoactive is increased.Wang Genwei carries out the mensuration of macrophage phagocytic function to the mice that takes 3 weeks of Cordyceps water extract, and the result shows that macrophage phagocytic function significantly strengthens, and presents dose-response relationship.The alone or synergistically PHA expression of inducing IL-2R such as the research surface Cordyceps polysaccharides in quiet main road etc., promote the generation of soluble IL 2R, but IL-2, the active selective inhibitory action of interferon gamma (IFN-γ) that PHA is induced, it is worked in coordination with or inhibitory action all is dose dependent, and the prompting Cordyceps polysaccharide has two-way immunoregulation effect to the peripheral blood lymphocyte of In vitro culture.
Herba Cistanches
Herba Cistanches is the kidney invigorating and YANG supporting Chinese medicine of commonly using, and the Herba Cistanches of have the kidney invigorating and essence nourishing, moisturizing is the kidney invigorating and YANG supporting Chinese medicine of commonly using, the function of have the kidney invigorating and essence nourishing, moisturizing.Because the particularity of Herba Cistanches parasitic growth breeding, in addition evident in efficacy and by artificial because the particularity of Herba Cistanches parasitic growth breeding is in addition evident in efficacy.The comparison of " insufficiency of kidney-YANG " mice cold-resistant function that hydrocortisone is caused.
Choose 60 of the male mice in kunming of the male mice in kunming of body weight 28 ± 2g,, be divided at random 6 groups, 10 every group.Except blank (normally) matched group, all the other only respectively organize equal intramuscular injection hydrogenation.0.8mg/10g.d successive administration 10 days, to " insufficiency of kidney-YANG " model group mice major part occur hair loose or lose hair or feathers, become thin, spiritlessness and weakness and cold physique tail are cold etc. typically till " insufficiency of kidney-YANG " symptom.The normal saline of simultaneously blank (normally) matched group of moulding, model group gavage 0.2ml/10g.d, other 4 groups difference gavage group difference gavage 0.2ml/10g.d, concentration is 0.5g/ml, 1.0g/ml Herba Cistanches decocting liquid, and concentration is 0.5g/ml, 1.0g/ml Cistanche Tubulosa decocting liquid.Behind the last administration 1h with animal according to grouping, be put in respectively in the different large cartons, place constant temperature refrigerator (5----7 ℃), record animal life span at low temperatures the results are shown in Table in 2,
Table 8 Herba Cistanches and the effect of Cistanche Tubulosa kidney invigorating and YANG supporting are relatively
Shown by the above results: two kinds all have the effect of certain warming and recuperating the kidney-YANG, Herba Cistanches and Cistanche Tubulosa decocting liquid all can obviously increase the body weight of " insufficiency of kidney-YANG " model mice, the cold-resistant time of " insufficiency of kidney-YANG " model mice is obviously prolonged, and its Signs is had to a certain degree improvement.As seen the two all has certain yang invigorating functions.
1, Herba Cistanches is on the impact of sperm concentration, motility rate, the speed of service and abnormal rate in the seminal fluid.
Table 9 Herba Cistanches is on the impact of sperm D, A, T, V
2, Herba Cistanches is on the impact of mice content of fructose in semen of male
The variation of table 10 mice content of fructose in semen of male
4, Herba Cistanches is on the succinate dehydrogenase (SDH) of mouse testis and epididymis, the impact of non-specific lipase (NSE)
The SDH reaction is all arranged in succinate dehydrogenase (SDH) the spermatogenic cells at different stages kytoplasm, and wherein stronger with spermatogonium, the reaction of Interstitial cell is extremely strong.The SDH positive particle is dispersed in distribution in the epididymal duct epithelial cell, and is more with the supranuclear region.Medication group SDH reaction is better than matched group.
Table 11 Herba Cistanches compares mouse testis and epididymis SDH, NSE response strength
The SDH of medication group, NSE are apparently higher than matched group P＜0.05
Spermatogenesis is the complex process of a multidate, comprising the abnormal three phases of the mitosis of spermatogonium, spermatocytal meiosis and spermatid.All there is its special metabolic type in each stage.The division of spermatogenic cells at different stages and spermatogenesis need enough nutrient substance and the adjusting of endocrine hormone in the seminiferous tubule.Motherland's traditional medicine thinks that Herba Cistanches has preferably kidney invigorating and YANG supporting effect, then can present androgen and the effect of promoting sexual gland hormone sample, with the function of endocrine regulation gland axle.Androgen is requisite hormone in the during spermatogenesis.Epididymis is the further ripe microenvironment of growing and breaking up of sperm, sperm depends on the synergism of epididymal in this process, epithelial secretion, absorption and substance transportation activity mainly are the microenvironments that the adjustable pipe intracavity is suitable for sperm development and differentiation and storage and tranquillization.The content of fructose is the important composition of reflection epididymal function in the refining, and medication group fructose content is apparently higher than matched group.SDH belongs to the enzyme of succinate oxidation enzyme system, in mitochondrion, arrange chaining, SDH is first enzyme of this system, be present in the cell of all aerobic respirations, with the mitochondrial membrane strong bonded, be most important enzyme in the dehydrogenase, in group reaction, be commonly used to reflect the situation of tricarboxylic acid cycle and become marker enzyme.Active hydrolysis and the steroidal with cholesterol of NSE is synthetic relevant, is commonly used to weigh the function of interstitial cell.The medicine number of SDH, NSE strong positive reaction is apparently higher than matched group in medication group testis and the epididymis, proves that Herba Cistanches really can promote testicular spermatogenic function, improve the microenvironment of epididymis.For the mechanism of Herba Cistanches kidney invigorating and YANG supporting effect provides reliable morphologic basis.
Radix Ginseng
Radix Ginseng is included in " Ministry of Public Health is about the notice of further standard healthy food material management " adnexa 2 and be can be used for the article list of health food.
The more bibliographical information of Radix Ginseng Radix Ginseng have the enhancing immunity function, think such as the people such as Luo Yanqiu experiment conclusion in " research that the Folium Ginseng Saponin is regulated chicken immuological function " literary composition that " Agriculture of Anhui science " delivered: the Folium Ginseng Saponin can promote the generation of chicken body internal specific antibody and the phagocytic activity of activated mononuclear-macrophage system.Chu Xiuling thinks at " ginsenoside's immunomodulating and Studies On Antiviral Activities " literary composition that " Chinese veterinarian's medical magazine " delivered: the ginsenoside can promote the growth of Immune Organs of Body, thereby directly affects immunity of organisms; The ginsenoside also can affect the stages of hematopoietic cell CFU-GM and hematopoietic stem cell, thereby strengthens the function of immunocyte, improves the resistance of body.The rich people of grade of imperial court tests in " Ginsenoside Rg3 is on the impact of immunologic function " literary composition that " China Medicine University's journal " delivered and shows: Ginsenoside Rg3 can obviously improve mice carbon clearance speed, immune organ weight, serum hemolysin content, splenocyte transforms and NK is active, illustrates that Ginsenoside Rg3 has the effect of raising immunologic function.The people such as Ren Jiehong experimental result in " ginsenoside Rg1's immunologic enhancement " literary composition that " new Chinese medicine and clinical pharmacology " delivered shows: ginsenoside Rg1 can increase the weight of mouse immune organ and the phagocytic function of macrophage, improves the content of IL-2, complement C3, C4 in the rat blood serum.Illustrate that Rg1 can improve the laboratory animal immunity of organisms, play the effect that improves the body defense function, immunologic enhancement is namely arranged.The people such as Zhao Wenli show at " progress of ginsenoside's antifatigue effect " literary composition of delivering of the 20th phase the 5th volume " Chinese food health magazine " in 2008 that the ginsenoside can produce by suppressing hydroxyl, oxygen-derived free radicals, the lipid peroxidation of hydrogen peroxide and the effect of accelerating the approach performance antioxidant radicals such as free radical scavenging, thereby reach the purpose of alleviating physical fatigue, the ginsenoside also has the effect that raising power exhausts ability and the enhances skeletal flesh SOD activity of postexercise recovery phase mice skeletal free radical resisting.Wang Ying, Cai Dong is associated in the ginseng effective component's Radix Ginseng total saponins (TSPG) that shows in " Advances of Research on Anti-Fatigue Effects of Panax ginseng " literary composition of delivering on " aminoacid and living resources " magazine with extracting, press various dose to the continuous gavage 7d of mice, measure the content of Mouse Blood Lactoferrin, the result shows, the gavage Radix Ginseng total saponins can increase the content of white mice hemoglobin, middle dosage group is the most obvious, increase by 6.6%, thereby can significantly increase the each degree of utilizing of breathing oxygen of mice, can increase Hb content in the erythrocyte by TSPG, and hemoglobin is to transport O in the blood
2And CO
2Main molecules, content of hemoglobin increases and both is conducive to provide more oxygen to muscular tissue in strenuous exercise, strengthens the aerobic metabolism energy supply, lactic acid produces and reduces, and accelerates simultaneously the removing of lactic acid, can also be in time with the CO that produces in the muscular tissue
2Be transported to lung and discharge, avoid because the muscle fatigue that pH descends and causes.This has positive role to the generation of delayed motion fatigue and the elimination that accelerates fatigue.Huanghai Sea English is delivered in " ginsenoside's pharmacological action " literary composition in the 1st phase of the 2nd volume February in 2003 " the up-to-date medical information digest in the world " and is shown, from neural, endocrine angle, chronic fatigue syndrome is relevant with disaster class substance metabolism confusion, the Radix Panacis Quinquefolii ginsenoside feeds mice, Ldh Activity and hepatic glycogen content and matched group increase more to some extent behind the 15d, 20min behind the mouse movement behind the 29d, the serum lactate level of 5min not only is starkly lower than matched group, and is lower than this group test level.In addition, the ginsenoside can increase the content of myosin adenosinetriphosphataes, and is tired due to relieve chronic fetters.Studies show that the ginsenoside has regulated the confusion of the Monoamines of confirmed fatigue animal to a certain extent, this mechanism may be that Chinese medicine significantly improves one of the fatigue performance of confirmed fatigue animal and reason of ability of learning and memory.The people such as Pan Huashan deliver in the 2nd phase of the 40th volume April in 2009 " Fujian Chinese medicine " in " ginsenoside Re and Radix Ginseng total saponins are on sports fatigue rat hypothalamus Ach, DA, 5-HT and contain the impact that GABA measures " literary composition and show, the mensuration of sports fatigue rat model Hypothalamic Neurotransmitter acetylcholine, dopamine, 5-hydroxy tryptamine and alpha-aminobutyric acid content that the equicohesive treadmill exercise of centering copies, find that ginsenoside Re and Radix Ginseng total saponins all can effectively improve the content of acetylcholine and dopamine, reduce the content of 5-hydroxy tryptamine and γ-aminobutyric acid.Organize comparison with the ginsenoside Re, Radix Ginseng total saponins group rat hypothalamus Ach, 5-HT and GABA have significance to reduce, and DA content has significance to raise.China Ceng Meiyi, the Li Minmin of Academy of Traditional Chinese Medicine and Ministry of Public Health drug evaluation center Zhao Xiu literary composition " new Chinese medicine with face the window pharmacology " March in 1997 the 8th volume the 1st interim " the Radix Ginseng toxicologic study " delivered show: 1. BerteShi (1982) mixes standardization Radix Ginseng journey cream c115 (the lower G115 of abbreviation) and feeds mice, rat and miniature pig (miniPig) rat, mice single oral dose in the feedstuff and be respectively 2000mg, 3000mg, 4000mg and 5000mg/kg, lumbar injection dosage is respectively 250mg, 500mg and 1000mg/kg, and the observation period is 14d.The oral GII5 LD of rat and mice
10All＞1000mg/kg.The oral chaste tree amount of miniature pig 2000mg/kg observes 7d.Record its body weight, detection hematology, blood biochemical numerical value, have no any toxic reaction; 2. Savel (1971) gives Oral Administration in Rats c115, and every daily dose is 4000mg/kg.Hematology's detection and organ histology microscopy behind the 20d training medicine is all normal continuously; 3. HessShi etc. (1983) feeds G115 for 32 Beagle Canis familiaris L.s, and every daily dose is 0,1.5,5.0 and 15mg/kg.For the time 90d.Investigated the absolute and relative weight of body weight, food ration, organ of animal; Hematology and blood biochemical are learned and are detected, and are showed no any abnormal response that is produced by medicine.The histological examination of high dose group and control animals, the result also has no the toxic reaction relevant with medicine.Think that daily dose is that the G115 extractum of 15mg/kg does not have chronic toxicity.
Pregelatinized Starch, microcrystalline Cellulose, Icing Sugar, magnesium stearate
Consider the operability of the course of processing and medicine mouthfeel we selected food additive pregelatinized Starch, microcrystalline Cellulose, Icing Sugar, magnesium stearate as antiplastering aid and flow aid, sweeting agent, disintegrating agent, show in " microcrystalline Cellulose---a kind of multi-functional macromolecular material " literary composition of delivering in " Chemical Industry in Guangzhou " the 3rd phase of the 21st volume in 1993 according to the Zhu Yu of Guangzhou Inst of Chemistry, Chinese Academy of Sciences qin, Tang Liegui, Pan Songhan: microcrystalline Cellulose can be used as antiplastering aid.The microcrystalline Cellulose addition meets GB2760 " food additive use sanitary standard " for 11% of prescription, and microcrystalline Cellulose toxicity ADI does not do particular provisions (FAO/WHO, 1994), makes like this its whole prescription have more reasonability and science.
Several raw materials are mutually auxiliary in whole prescription more than this specific embodiment deposits mutually, brings out the best in each other, and makes full side present preferably effect, and product has obvious kidney supplementing yang invigorating health care function through function test proof this product.
Claims (5)
1. kidney supplementing yang invigorating health care medicine, it is characterized in that leek extract 6-10g, Radix Morindae Officinalis 4-9g, Cordyceps 4-9g, Herba Cistanches 6-12g, Radix Ginseng 4-9g, beta-schardinger dextrin-3-8g, pregelatinized Starch 4-10g, microcrystalline Cellulose 3-8g, Icing Sugar 6-15g, magnesium stearate 0.3-1g.
2. health medicine according to claim 1, it is characterized in that, the recipe ratio of this medicine is leek extract 6g, Radix Morindae Officinalis 4g, Cordyceps 4g, Herba Cistanches 2g, Radix Ginseng 4g, beta-schardinger dextrin-3g, pregelatinized Starch 4g, microcrystalline Cellulose 3g, Icing Sugar 6g, magnesium stearate 0.3g.
3. health medicine according to claim 1, it is characterized in that, the recipe ratio of this medicine is leek extract 10g, Radix Morindae Officinalis 9g, Cordyceps 9g, Herba Cistanches 12g, Radix Ginseng 9g, beta-schardinger dextrin-8g, pregelatinized Starch 10g, microcrystalline Cellulose 8g, Icing Sugar 15g, magnesium stearate 1g.
4. health medicine according to claim 1, it is characterized in that, the recipe ratio of this medicine is leek extract 8g, Radix Morindae Officinalis 6g, Cordyceps 5.5g, Herba Cistanches 7.2g, Radix Ginseng 6.7g, beta-schardinger dextrin-5.6g, pregelatinized Starch 6.4g, microcrystalline Cellulose 5.5g, Icing Sugar 7.8g, magnesium stearate 0.56g.
5. method for preparing each described kidney supplementing yang invigorating health care medicine of claim 1-4, it is characterized in that, first Radix Morindae Officinalis, Cordyceps, Herba Cistanches, Radix Ginseng are pulverized respectively, cross the 60-80 mesh sieve, various drug powders and other supplementary material after weighing is pulverized mix, incorporation time control 45-50 minute, then carry out capsule-filling, filling process is filled the weight of medicated powder according to inner quality standard control, select again, polishing, inner packing, outer package, according to touchstone check warehouse-in.
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