CN112316046B - Application of traditional Chinese medicine composition in preparation of medicine for treating atherosclerosis - Google Patents

Abstract

The invention provides application of a traditional Chinese medicine composition in preparing a medicine for treating atherosclerosis, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 150-350 parts of semen cuscutae, 100-200 parts of wolfberry fruit, 30-60 parts of schisandra chinensis, 20-50 parts of fructus cnidii, 20-50 parts of fructus rosae laevigatae, 20-50 parts of semen allii tuberosi, 20-50 parts of morinda officinalis, 20-50 parts of cistanche, 30-60 parts of radix rehmanniae recen, 20-50 parts of radix cyathulae, 40-100 parts of herba epimedii, 20-50 parts of raspberry, 15-35 parts of ginseng, 10-25 parts of cornu cervi pantotrichum, 15-35 parts of hippocampus and 15-35 parts of fructus toosendan.

Description

Application of traditional Chinese medicine composition in preparation of medicine for treating atherosclerosis

Technical Field

The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of the traditional Chinese medicine composition in preparing a medicine for treating arteriosclerosis.

Background

Atherosclerosis (AS) is a chronic, systemic vascular inflammatory process that underlies the pathology of coronary artery disease and stroke. Cardiovascular and cerebrovascular end-point events finally caused by AS are equivalent in men and women, but because estrogen has a protective effect on cardiovascular diseases, the incidence rate of coronary heart diseases of women before menopause is only 1/10-3/10 of that of men, and the incidence rate of coronary heart diseases of women after menopause is increased by 10 times, and menopause becomes one of the key factors for increasing the risk of cardiovascular diseases of women. By 2050, 10 million women worldwide will enter menopause, and thus, have great significance in the study of post-menopausal atherosclerosis.

The AS lesion is located in the "vein", and belongs to the typical "choroid-vasculature disease". The theory of blood vessels in the "Nei Jing" was inherited and developed by the theory of the vessel-vessel system, and the concept of the disease of vessel-vessel system was proposed based on the knowledge of the close correlation of vessel-vessel system. The narrow definition of "choroid-vascular system disease" mainly refers to the disease of damaged self-function and structure of the choroid, and its extension includes the pathogenic factors of choroid pathological changes and pathological changes of viscera tissues caused by choroid pathological changes. The 'chest stuffiness' and 'heart pain' are firstly proposed in the 'Nei Jing', and the theory of collateral diseases guides the pathogenesis research of the disease to believe that the heart pain is mainly obstructed in the chest by cold congealing, qi stagnation, blood stasis and phlegm and fluid retention, which leads to obstruction or dwarfing of the venation and even obstruction of the venation. For example, "plain questions, extreme important treatises" cloud: "the cold excesses in the blood change pulse, … … heart pain of the disease of people" ", the theory of plain question and lifting pain" is recorded: 'Cold qi flowing outside the pulse causes cold in the pulse, cold in the pulse constricts the pulse, and the pulse constricts the pulse urgently, which leads to small collateral and causes stroke but pain'. Although typical of the disease of the choroid-vascular system, AS is closely related to qi. The functional structure carrier for realizing qi action is qi collaterals which have physiological functions of regulating, warming, nourishing, defending, protecting, information transmission, self-stabilization regulation and the like, wherein postmenopausal AS is related to the regulation and self-stabilization regulation of qi collaterals. Collaterals of meridians function in regulating, connecting viscera, limbs, bones and five sense organs, nine orifices of meridians into a whole. The self-stabilization regulation is an internal regulation mechanism for maintaining the life health state formed in the long-term evolution process of organisms, and not only maintains the dynamic balance of the environment in the organisms, but also maintains the harmonious balance of the organisms and the environment outside the natural society. The traditional Chinese medicine highly summarizes the self-stabilization balance as yin-yang balance, the theory of Su Wen and Sheng Qi Tong Tian (plain questions and Qi generating Tong Lun) says "secret at the level of yang and treatment of psychic, wang Bing notes that the harmonization of yin qi and the closure of yang qi are increasingly treated, and the harmony balance of yin and yang qi indicates that the homeostasis of the body and spirit can be maintained.

The medicine provided by the invention is used as a representative prescription for tonifying kidney and replenishing essence, and basic research and clinical research carried out in the early stage show that the medicine has multiple functions, for example, the medicine can keep the weight, reduce the body fat weight and the body fat rate, maintain the exercise endurance and improve the anaerobic exercise capacity, and maintain the serum testosterone level stability of athletes, and has no stimulant-like effect in the preparation period and the competition period before the competition of athletes. The medicine provided by the invention is used for treating kidney deficiency and kidney deficiency type impotence, and proves that the medicine has a good improvement effect on symptoms such as soreness and weakness of waist and knees, mental fatigue and hypodynamia, dizziness and tinnitus, amnesia, hyposexuality, impotence and the like, and no adverse reaction is found in clinical observation.

Disclosure of Invention

The medicine of the invention is prepared from medlar and dodder seed for tonifying the kidney and replenishing vital essence, schisandra chinensis, raspberry and cherokee rose for tonifying the kidney and consolidating the vital essence, and cnidium monnieri and leek seed for tonifying yang and replenishing vital essence. Only Chuan Lian Zi is not good at tonifying but good at moving qi, so in qi-regulating herbs, chuan Lian Zi is good at regulating qi of liver and kidney in lower energizer and tonifying kidney essence, so it has the action of tonifying without stagnation. According to the theory of ' essence deficiency in Huangdi ' of the internal Jing, supplement the flavor ' and ' love in essence filling ' of Yetianshi, the combination of two herbs with blood and meat of pilose antler and sea horse is used to tonify the kidney and fill the essence, and is combined with the other herbs to complement each other. Cornu Cervi Pantotrichum, ben Cao gang mu, is called "producing essence and replenishing marrow, nourishing blood and tonifying yang, strengthening tendons and bones" and is the essential herb for replenishing kidney essence; hippocampus has effects of invigorating kidney, replenishing essence, and harmonizing qi and blood. On the basis of the medicine for tonifying kidney essence, the medicine is combined with radix rehmanniae for nourishing kidney yin, epimedium herb, morinda officinalis and cistanche for assisting kidney yang so as to regulate yin and yang; ginseng radix for invigorating primordial qi (inspired by medical science) is added to tonify true qi and promote blood circulation; achyranthes root, radix Achyranthis bidentatae, tonifying the liver and kidney, directing all herbs downward, as in the book of Yi Xue Zhong Can xi Lu: original niu xi is tonic and good at directing qi downward and blood downward, which is to be induced by the drugs to go downward, niu xi has the action of smoothing collaterals and qi, ren Shen and niu xi have the action of tonifying drugs. The medicines are combined to play the roles of tonifying kidney essence, regulating yin and yang, tonifying kidney qi and promoting blood circulation to achieve the comprehensive functions of tonifying kidney and dredging collaterals.

The invention provides application of a traditional Chinese medicine composition in preparing a medicine for treating atherosclerosis, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 150-350 parts of semen cuscutae, 100-200 parts of wolfberry fruit, 30-60 parts of schisandra chinensis, 20-50 parts of fructus cnidii, 20-50 parts of fructus rosae laevigatae, 20-50 parts of semen allii tuberosi, 20-50 parts of morinda officinalis, 20-50 parts of cistanche, 30-60 parts of radix rehmanniae recen, 20-50 parts of radix cyathulae, 40-100 parts of herba epimedii, 20-50 parts of raspberry, 15-35 parts of ginseng, 10-25 parts of cornu cervi pantotrichum, 15-35 parts of hippocampus and 15-35 parts of fructus toosendan.

The preferred traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 150 parts of semen cuscutae, 200 parts of fructus lycii, 30 parts of fructus schizandrae, 50 parts of fructus cnidii, 20 parts of fructus rosae laevigatae, 20 parts of semen allii tuberose, 50 parts of morinda officinalis, 20 parts of herba cistanche, 30 parts of radix rehmanniae recen, 50 parts of radix cyathulae, 40 parts of herba epimedii, 50 parts of raspberry, 15 parts of ginseng, 25 parts of cornu cervi pantotrichum, 15 parts of hippocampus and 35 parts of fructus toosendan.

The preferred traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 350 parts of dodder seed, 100 parts of medlar, 60 parts of schisandra chinensis, 20 parts of fructus cnidii, 50 parts of cherokee rose fruit, 50 parts of semen allii tuberosi, 20 parts of morinda officinalis, 50 parts of cistanche, 60 parts of radix rehmanniae recen, 20 parts of medicinal cyathula root, 100 parts of epimedium herb, 20 parts of raspberry, 35 parts of ginseng, 10 parts of pilose antler, 35 parts of hippocampus and 15 parts of szechwan chinaberry fruit.

The preferred traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 250 parts of semen cuscutae, 138 parts of fructus lycii, 46 parts of fructus schizandrae, 35 parts of fructus cnidii, 35 parts of fructus rosae laevigatae, 35 parts of semen allii tuberose, 35 parts of morinda officinalis, 35 parts of herba cistanche, 46 parts of radix rehmanniae recen, 35 parts of radix cyathulae, 70 parts of herba epimedii, 35 parts of raspberry, 25 parts of ginseng, 16 parts of cornu cervi pantotrichum, 21 parts of hippocampus and 23 parts of fructus toosendan.

The preferred traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 250 parts of dodder, 150 parts of medlar, 45 parts of schisandra chinensis, 30 parts of fructus cnidii, 30 parts of cherokee rose fruit, 30 parts of semen allii tuberosi, 30 parts of morinda officinalis, 30 parts of cistanche, 45 parts of radix rehmanniae recen, 30 parts of medicinal cyathula root, 70 parts of epimedium, 30 parts of raspberry, 20 parts of ginseng, 19 parts of pilose antler, 20 parts of hippocampus and 20 parts of szechwan chinaberry fruit.

The dosage form of the medicine provided by the invention is decoction, capsules, tablets, granules, powder or pills.

In order to achieve the purpose of the invention, the traditional Chinese medicine composition is prepared into various pharmaceutical dosage forms, theoretically, the traditional Chinese medicine composition can be prepared into any dosage form according to a general preparation method, and the traditional Chinese medicine composition is preferably decoction, capsules, tablets, granules, powder or pills according to the applicable objects and indications. In order to make the above dosage forms possible, pharmaceutically acceptable excipients, such as: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, and the like. The filler comprises: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; the disintegrating agent comprises: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crospolyvinylpyrrolidone, low-substituted hydroxypropylcellulose, croscarmellose sodium, etc.; the lubricant comprises: magnesium stearate, sodium lauryl sulfate, talc, silica, and the like; the suspending agent comprises: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, and the like; the adhesive comprises starch slurry, polyvinylpyrrolidone, hydroxypropyl methylcellulose, etc.; the sweetener comprises: saccharin sodium, aspartame, sucrose, sodium cyclamate, glycyrrhetinic acid and the like; the flavoring agent comprises: sweeteners and various essences; the preservative comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its salts, benzalkonium bromide, chloroacetidine acetate, eucalyptus oil, etc.; the matrix comprises: PEG6000, PEG4000, insect wax, etc.

The preparation method of the capsule comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 6-10 times of 70% ethanol, reflux extracting for 1-3 times, each for 1-3 hr, filtering, mixing filtrates, recovering ethanol under reduced pressure to obtain ethanol extract;

b. mixing the medicinal material residues after the alcohol extraction in the step a with wolfberry fruit, radix rehmanniae recen, raspberry, cherokee rose fruit, chinese chive seed, morinda officinalis and szechwan chinaberry fruit in proportion, adding 7-12 times of water, decocting for 1-3 times each time for 1-3 hours, filtering, mixing the filtrates, mixing with the alcohol extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.25-1.30 measured at 60 ℃ to obtain an extract;

c. weighing the ginseng, the pilose antler, the hippocampus, the cistanche and the medicinal cyathula root according to the proportion, crushing into fine powder, uniformly mixing with the extract obtained in the step b, drying at 60-70 ℃, crushing, sieving and filling into capsules.

The atherosclerosis according to the invention is preferably postmenopausal atherosclerosis.

The medicament for treating arteriosclerosis diseases has the advantages of small side effect, good effect, convenient use and low price.

Drawings

FIG. 1: each group of the dyeing results are generally oil red O, wherein Model is a Model group; the G1 group is a positive control drug group; the HD-BZ group is a drug high-dose group; LD-BZ the low dose group of the agents of the invention; control is a Control group

FIG. 2: performing HE staining and oil red O staining on the root part of each group of aorta, wherein the Model is a Model group; g1 group is high fat diet + G1.2 ug/d subcutaneous injection; the HD-BZ group is a drug high-dose group; LD-BZ the low dose group of the agents of the present invention; control is a Control group.

Detailed Description

Example 1: preparation of capsules

The formula is as follows: 250g of semen cuscutae, 138g of wolfberry fruit, 46g of schisandra fruit, 35g of fructus cnidii, 35g of cherokee rose fruit, 35g of semen allii tuberosi, 35g of morinda officinalis, 35g of cistanche, 46g of radix rehmanniae recen, 35g of radix cyathulae, 70g of herba epimedii, 35g of raspberry, 25g of ginseng, 16g of cornu cervi pantotrichum, 21g of hippocampus and 23g of fructus toosendan;

the preparation method comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 3208ml70% ethanol, reflux extracting for 3 times, each for 2 hr, filtering, mixing filtrates, recovering ethanol under reduced pressure to obtain ethanol extract;

b. mixing the medicinal material residues after the alcohol extraction in the step a with wolfberry fruit, radix rehmanniae recen, raspberry, cherokee rose fruit, chinese chive seed, morinda officinalis and szechwan chinaberry fruit in proportion, adding 6732ml of water for decoction for 2 times, each time for 2 hours, filtering, mixing the filtrates, mixing with the alcohol extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.28 measured at 60 ℃ to obtain an extract;

c. weighing the ginseng, the pilose antler, the hippocampus, the cistanche and the medicinal cyathula root according to the proportion, crushing into fine powder, uniformly mixing with the extract obtained in the step b, drying at 60-70 ℃, crushing, sieving, and filling into capsules to obtain 757 capsules.

Example 2: preparation of tablets

The formula is as follows: 250g of dodder, 150g of medlar, 45g of schisandra chinensis, 30g of fructus cnidii, 30g of cherokee rose, 30g of Chinese chive seed, 30g of morinda officinalis, 30g of cistanche, 45g of radix rehmanniae recen, 30g of medicinal cyathula root, 70g of epimedium herb, 30g of raspberry, 20g of ginseng, 19g of pilose antler, 20g of hippocampus and 20g of szechwan chinaberry fruit;

the preparation method comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 2765ml70% ethanol, reflux extracting for 3 times, each for 1 hr, filtering, mixing filtrates, and recovering ethanol under reduced pressure to obtain ethanol extract;

b. mixing the medicinal material residues after the alcohol extraction in the step a with wolfberry fruit, radix rehmanniae recen, raspberry, cherokee rose fruit, chinese chive seed, morinda officinalis and szechwan chinaberry fruit in a certain proportion, adding 5110ml of water for decocting for 1 time for 3 hours, filtering, mixing the filtrates, mixing with the alcohol extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.30 measured at 60 ℃ to obtain an extract;

c. weighing the ginseng, the pilose antler, the sea horse, the cistanche and the medicinal cyathula root according to the proportion, crushing into fine powder, uniformly mixing with the extract obtained in the step b, drying at 60-70 ℃, crushing, sieving, adding 1% of magnesium stearate, and tabletting to obtain 760 tablets.

Example 3: preparation of pills

The formula is as follows: 350g of semen cuscutae, 100g of wolfberry fruit, 60g of schisandra chinensis, 20g of fructus cnidii, 50g of cherokee rose fruit, 50g of semen allii tuberosi, 20g of morinda officinalis, 50g of cistanche, 60g of radix rehmanniae recen, 20g of radix cyathulae, 100g of herba epimedii, 20g of raspberry, 35g of ginseng, 10g of cornu cervi pantotrichum, 35g of hippocampus and 15g of fructus toosendan;

the preparation method comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 5300ml70% ethanol, reflux extracting for 1 time and 3 hr, filtering, mixing filtrates, recovering ethanol under reduced pressure to remove ethanol smell to obtain ethanol extract;

b. mixing the medicinal material residues after the alcohol extraction in the step a with wolfberry fruit, radix rehmanniae recen, raspberry, cherokee rose fruit, chinese chive seed, morinda officinalis and szechwan chinaberry fruit in a proportion, adding 10140ml of water, decocting for 3 times, each time for 1 hour, filtering, mixing the filtrates, mixing with the alcohol extraction extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.25 measured at 60 ℃ to obtain an extract;

c. weighing Ginseng radix, cornu Cervi Pantotrichum, hippocampus, cistanchis herba, and radix Cyathulae at a certain proportion, pulverizing into fine powder, mixing with the extract obtained in step b, drying at 60-70 deg.C, pulverizing, sieving, and making into pill to obtain 320g pill.

Example 4: preparation of granules

The formula is as follows: 150g of semen cuscutae, 200g of wolfberry fruit, 30g of schisandra chinensis, 50g of fructus cnidii, 20g of cherokee rose fruit, 20g of semen allii tuberosi, 50g of morinda officinalis, 20g of cistanche, 30g of radix rehmanniae recen, 50g of radix cyathulae, 40g of herba epimedii, 50g of raspberry, 15g of ginseng, 25g of cornu cervi pantotrichum, 15g of hippocampus and 35g of fructus toosendan;

the preparation method comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 2430ml70% ethanol, reflux extracting for 2 times, each for 1.5 hr, filtering, mixing filtrates, recovering ethanol under reduced pressure to obtain ethanol extract;

b. mixing the residue of the medicinal materials extracted by the alcohol in the step a with the other medicinal materials in proportion, adding 8800ml of water, decocting for 3 times, 1 hour each time, filtering, mixing the filtrates, mixing with the alcohol extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.29 measured at 60 ℃ to obtain an extract;

c. and c, uniformly mixing the extract obtained in the step b with 300g of dextrin and 200g of sucrose powder, drying at 60-70 ℃, crushing, sieving and granulating to obtain 700g of granules.

Example 5: preparation of powder

The formula is as follows: 250g of semen cuscutae, 150g of wolfberry fruit, 45g of schisandra fruit, 30g of fructus cnidii, 30g of cherokee rose fruit, 30g of semen allii tuberosi, 30g of morinda officinalis, 30g of cistanche, 45g of radix rehmanniae recen, 30g of radix cyathulae, 70g of herba epimedii, 30g of raspberry, 20g of ginseng, 19g of cornu cervi pantotrichum, 20g of hippocampus and 20g of fructus toosendan;

the preparation method comprises the following steps: weighing the traditional Chinese medicinal materials in the formula according to the proportion, mixing and crushing the traditional Chinese medicinal materials into fine powder to obtain 823g of powder.

Example 6: preparation of decoction

The formula is as follows: 250g of semen cuscutae, 150g of wolfberry fruit, 45g of schisandra fruit, 30g of fructus cnidii, 30g of cherokee rose fruit, 30g of semen allii tuberosi, 30g of morinda officinalis, 30g of cistanche, 45g of radix rehmanniae recen, 30g of radix cyathulae, 70g of herba epimedii, 30g of raspberry, 20g of ginseng, 19g of cornu cervi pantotrichum, 20g of hippocampus and 20g of fructus toosendan;

the preparation method comprises the following steps: weighing traditional Chinese medicinal materials in a formula according to a certain proportion, adding water until the traditional Chinese medicinal materials are submerged, soaking for 15 minutes, heating until the water is boiled, continuing decocting for 30 minutes with slow fire, filtering, adding water again until the medicinal materials are submerged, decocting for 30 minutes again, filtering, and combining the filtrates to obtain 4320g decoction.

Test examples: to clarify that the drug of the present invention is capable of resisting post-menopausal atherosclerosis, the following animal experiments were conducted using the drug prepared in example 1 (hereinafter referred to as the drug of the present invention):

1. animal grouping and Experimental design

60 female homozygote ApoE-/-mice and 15 female C57BL/6J mice, both 6-8 weeks old, were purchased from Jiangsu Jiejicakang Biotechnology Ltd. The animal feeding conditions are 22 deg.C, 12h/12h light and dark circadian rhythm, no food limit and water limit. 3 days after adaptive feeding, apoE-/-mice received bilateral ovariectomy (surgical menopausal model) and C57BL/6J mice were given sham surgery. After 1 week, apoE-/-mice were randomized into 4 groups (n = 15/group): model group (Model) (high fat diet +0.5% sodium carboxymethyl cellulose (CMC) gavage), G1 group (high fat diet + G1.2 ug/d subcutaneous injection), inventive drug high dose group (HD-BZ) (high fat diet + inventive drug 2.8G/kg/d gavage), inventive drug low dose group (LD-BZ) (high fat diet + inventive drug 1.4G/kg/d gavage), and 15C 57BL/6J mice were Control group (Control) (normal diet + CMC gavage). Normal diet (standard diet) was purchased from molal diet ltd (M10001, chengdu), high fat diet (no phytoestrogen, 40% fat, 1.25% cholesterol, 0.5% bile acid) was purchased from Research diet ltd (D12109C, new jersey, USA).

2. Mouse serum sampling

After feeding on the regular diet or high-fat diet for 12 weeks, all mice were fasted for 12 hours overnight and were drawn on the second day. Blood was collected from the eyes, centrifuged at 3000rpm for 15 minutes to collect serum, and Total Cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) kits were purchased from Beijing Jiuqiang Biometrics Ltd (GS 101Z, GS111Z, GS141Z/S, GS131Z/S, beijing).

3. Quantification of atherosclerotic lesion extent

Severity of atherosclerosis was assessed by aortic gross oil red O staining and aortic root oil red O staining and HE staining.

4. Results

4.1 staining results for each group of gross oil Red O:

compared with Control, model plaques are increased remarkably, compared with Model, G1 and the drug group of the invention can reduce plaques remarkably, and the HD-BZ effect is superior to that of LD-BZ group.

4.2 aorta root HE staining and oil red O staining results of each group:

compared with Control, model plaques are increased remarkably, compared with Model, the plaques can be reduced remarkably by G1 and the drug group of the invention, and the HD-BZ effect is superior to that of LD-BZ group and is equivalent to that of positive drug G1.

5. And (4) conclusion: the experimental research shows that the medicine can obviously reduce the area of aortic plaques of high-fat fed menopausal model mice, has certain dose dependence and better high dose effect, has the same effect as positive drug effect, and shows that the medicine has the function of resisting postmenopausal atherosclerosis.

Claims (3)

1. The application of a traditional Chinese medicine composition in preparing a medicine for treating postmenopausal atherosclerosis is disclosed, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 150 parts of dodder, 200 parts of medlar, 30 parts of schisandra chinensis, 50 parts of fructus cnidii, 20 parts of cherokee rose fruit, 20 parts of semen allii tuberosi, 50 parts of morinda officinalis, 20 parts of cistanche deserticola, 30 parts of radix rehmanniae recen, 50 parts of radix cyathulae, 40 parts of epimedium, 50 parts of raspberry, 15 parts of ginseng, 25 parts of pilose antler, 15 parts of hippocampus, 35 parts of szechwan chinaberry fruit, or 350 parts of dodder, 100 parts of medlar, 60 parts of schisandra chinensis, 20 parts of fructus cnidii, 50 parts of cherokee rose fruit, 50 parts of semen allii tuberosi, 20 parts of morinda officinalis, 50 parts of cistanche deserticola, 60 parts of radix rehmanniae recen, 20 parts of radix cyathulae, 100 parts of epimedium, 20 parts of raspberry, 35 parts of ginseng, 10 parts of pilose antler, 35 parts of hippocampus, and 15 parts of szechwan chinaberry fruit, or dodder seed 250, medlar 138, schisandra 46, cnidium fruit 35, cherokee rose 35, leek seed 35, morinda root 35, broomrape 35, dried rehmannia root 46, cyathula root 35, epimedium 70, raspberry 35, ginseng 25, pilose antler 16, hippocampus 21, toosendan fruit 23, or dodder seed 250, medlar 150, schisandra 45, cnidium fruit 30, cherokee rose 30, leek seed 30, morinda root 30, broomrape 30, dried rehmannia root 45, cyathula root 30, epimedium 70, raspberry 30, ginseng 20, pilose antler 19, hippocampus 20, toosendan fruit 20.

2. The use of claim 1, wherein the medicament is in the form of decoction, capsule, tablet, granule, powder or pill.

3. Use according to claim 2, characterized in that the process for the preparation of the capsules comprises the following steps:

a. weighing fructus Cnidii, semen Cuscutae, fructus Schisandrae chinensis, and herba Epimedii at a certain proportion, adding 6-10 times of 70% ethanol, reflux extracting for 1-3 times, each for 1-3 hr, filtering, mixing filtrates, recovering ethanol under reduced pressure to obtain ethanol extract;

b. b, mixing the medicinal material residues obtained after the alcohol extraction in the step a with wolfberry fruit, radix rehmanniae recen, raspberry, cherokee rose fruit, chinese chive seed, morinda officinalis and szechwan chinaberry fruit in a proportional amount, adding 7-12 times of water, decocting for 1-3 times, each time for 1-3 hours, filtering, mixing the filtrates, mixing with the alcohol extract obtained in the step a, and concentrating under reduced pressure until the relative density is 1.25-1.30 measured at 60 ℃ to obtain an extract;

c. weighing the ginseng, the pilose antler, the hippocampus, the cistanche and the medicinal cyathula root according to the proportion, crushing into fine powder, uniformly mixing with the extract obtained in the step b, drying at 60-70 ℃, crushing, sieving and filling into capsules.

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