CN101670080A - Chinese medicinal composition for chronic gastritis and preparation process thereof - Google Patents
Chinese medicinal composition for chronic gastritis and preparation process thereof Download PDFInfo
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- CN101670080A CN101670080A CN200810119842A CN200810119842A CN101670080A CN 101670080 A CN101670080 A CN 101670080A CN 200810119842 A CN200810119842 A CN 200810119842A CN 200810119842 A CN200810119842 A CN 200810119842A CN 101670080 A CN101670080 A CN 101670080A
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Abstract
The invention discloses a Chinese medicinal composition for chronic gastritis and a preparation process thereof. The effective component of the composition is prepared from dozens of medicinal materials, such as ginseng, immature bitter orange, Indian bread, jujube kernel, dried longan pulp, largehead atractylodes rhizome, astragalus mongholicus, Chinese angelica, nutgrass galingale rhizome, freshginger, thinleaf milkwort root, malt, costustoot, chicken's gizzard-membrane, liquorice root and the like through extraction. The unique medicinal active component in the composition has the effectsof activating blood, diminishing inflammation, astringing, relieving pains, and is used for treating gastric cavity and abdominal pain, thermophilic gastric cavity, sour regurgitation and belching andother diseases caused by the chronic gastritis.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of chronic gastritis Chinese medicine composition and preparation technology thereof of being used for.
Technical background
Chronic gastritis comprises chronic superficial gastritis and chronic atrophic gastritis.According to relevant report on Epidemiological, China's chronic gastritis sickness rate is 86%.What China's the nineties ten big pathogenesis of cancer mortality rates that " healthy newspaper " announced in 96 years accounted for the first place is gastric cancer.When chronic superficial gastritis developed into chronic atrophic gastritis, gastric mucosa made the secretory function of normal gastric mucosa change into the absorption function that stomach lacks with the enteraden epithelial metaplasia, had prepared condition for carcinogen such as flavacin, phenylhydrazine Bi.Atrophic gastritis is " soil " that canceration takes place thus.
Therefore atrophic gastritis is classified as one of gastric cancer state in early stage by World Health Organization (WHO).Which symptom does atrophic gastritis have? distending pain under epigastrium and the left and right sides rib, frequent, the noisy discomfort of belch, anorexia are often arranged clinically, the time have that nauseating, vomiting, gastral cavilty are scorching hot, rare when doing when xerostomia, bitter taste, stool, stool is not well, bile reflux causes esophagus or anterior pectorial region discomfort, gastric mucosa attenuation under radioactivity back pain, foreign body in pharynx sense, headache, insomnia etc. and the gastroscope, vasoganglion sees that thoroughly color and luster is with Bai Weizhu (normally being salmon pink).The atrophy of pathological examination body of gland reduces, and clectrogastrogram amplitude frequency reduces.
Investigate according to WHO, suffer from atrophic gastritis in 20-53 year only more than 10%, 51-65 year is for suffering from atrophic gastritis up to more than 50, according to our investigation statistics, annual growth of age 10 years old, the particularly middle severe atrophic gastritis of the average 14% above chronic atrophic gastritis patient that rises is with intestinal gland metaplasia or atypical hyperplasia person (dysplasia) is arranged, the gastric cancer incidence rate is than general population height, there is the patient of 5%-10% finally can change gastric cancer into approximately, must gets in touch but there is no between atrophic gastritis and the gastric cancer.And, to give birth to and atypical hyperplasia for the change of gastric mucosa, as treat properly, pathological changes can reverse.
It is the theory that causes chronic gastritis that the present invention becomes estranged about Deficiency and coldness of spleen and stomach, liver stomach in strict accordance with the traditional Chinese medical science, in conjunction with long-term clinical practice, adopts genuine Chinese crude drug to make with extra care and forms.Have invigorate blood circulation, antiinflammatory, convergence, analgesic effect, can be warming middle-Jiao and tonifying deficiency, remove cold, regulating the liver and spleen in warm, can secrete by gastric acid inhibitory again, alleviate the stimulation of gastric acid to ulcer surface, promote mucosa regeneration and ulcer more and, thereby effectively treat diseases such as epigastric pain that disease such as chronic gastritis causes, abdomen gastral cavity happiness temperature, acid regurgitation belch.
Summary of the invention:
The purpose of this invention is to provide a kind of chronic gastritis Chinese medicine composition that is used for;
Another object of the present invention provides the preparation technology of this Chinese medicine composition;
Be achieved through the following technical solutions (part is unit of weight) order of the present invention:
1, prescription:
Radix Ginseng 100-300 part Fructus Aurantii Immaturus 100-300 part Poria cum Radix Pini 60-180 part
Endothelium Corneum Gigeriae Galli 60-180 part Semen Ziziphi Spinosae 60-180 part Arillus Longan 60-180 part
Rhizoma Atractylodis Macrocephalae 100-300 part Radix Astragali 100-300 part Radix Angelicae Sinensis 100-300 part
Rhizoma Cyperi 60-180 part Rhizoma Zingiberis Recens 60-180 part Radix Polygalae 100-300 part
Fructus Hordei Germinatus 60-180 part Radix Aucklandiae 60-180 part Radix Glycyrrhizae 60-180 part
Effective ingredient is preferably made by weight by following raw materials according:
120 parts of 200 parts of Poria cum Radix Pinis of 200 parts of Fructus Aurantii Immaturuss of Radix Ginseng
120 parts of 120 portions of Arillus Longans of 120 parts of Semen Ziziphi Spinosaes of Endothelium Corneum Gigeriae Galli
200 parts of 200 parts of Radix Angelicae Sinensis of 200 parts of Radixs Astragali of the Rhizoma Atractylodis Macrocephalae
200 parts of 120 parts of Radix Polygalaes of 120 portions of Rhizoma Zingiberis Recenss of Rhizoma Cyperi
120 parts in 120 portions of Radix Glycyrrhizaes of 120 parts of Radix Aucklandiae of Fructus Hordei Germinatus
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
2, preparation technology:
(1) Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis are with 70% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Fructus Aurantii Immaturus, Poria cum Radix Pini, Semen Ziziphi Spinosae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Rhizoma Zingiberis Recens, Radix Polygalae, Fructus Hordei Germinatus, the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 24 hours, and got supernatant, it is the thick paste of 1.20 (70 ℃) that concentrating under reduced pressure becomes relative density;
(3) with step (1) gained clear paste and step (2) gained thick paste mixing, drying is ground into fine powder, makes granule, capsule and pill with pharmaceutically acceptable carrier.
Adopt above-mentioned prescription and preparation method thereof, the present invention have invigorate blood circulation, antiinflammatory, convergence, analgesic effect, be used for the treatment of diseases such as epigastric pain that disease such as chronic gastritis causes, abdomen gastral cavity happiness temperature, acid regurgitation belch.
By the following examples technical scheme of the present invention is described further.
The specific embodiment
Embodiment 1: the preparation technology of granule
1, prescription:
120 parts of 200 parts of Poria cum Radix Pinis of 200 parts of Fructus Aurantii Immaturuss of Radix Ginseng
120 parts of 120 portions of Arillus Longans of 120 parts of Semen Ziziphi Spinosaes of Endothelium Corneum Gigeriae Galli
200 parts of 200 parts of Radix Angelicae Sinensis of 200 parts of Radixs Astragali of the Rhizoma Atractylodis Macrocephalae
200 parts of 120 parts of Radix Polygalaes of 120 portions of Rhizoma Zingiberis Recenss of Rhizoma Cyperi
120 parts in 120 portions of Radix Glycyrrhizaes of 120 parts of Radix Aucklandiae of Fructus Hordei Germinatus
2, preparation technology:
(1) Radix Ginseng 200g, Radix Astragali 200g, Radix Angelicae Sinensis 200g are with 70% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Fructus Aurantii Immaturus 200g, Poria cum Radix Pini 120g, Semen Ziziphi Spinosae 120g, Arillus Longan 120g, Rhizoma Atractylodis Macrocephalae 200g, Rhizoma Cyperi 120g, Rhizoma Zingiberis Recens 120g, Radix Polygalae 200g, Fructus Hordei Germinatus 120g, Radix Aucklandiae 120g, Endothelium Corneum Gigeriae Galli 120g, Radix Glycyrrhizae 120g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 24 hours, get supernatant, it is the thick paste of 1.20 (70 ℃) that concentrating under reduced pressure becomes relative density;
(3) step (1) gained clear paste and step (2) gained thick paste are added dextrin 600g, lactose 400g, mixing, drying is ground into fine powder, with 75% ethanol wet granulation promptly.
Embodiment 2: the preparation technology of capsule
1, prescription:
120 parts of 200 parts of Poria cum Radix Pinis of 200 parts of Fructus Aurantii Immaturuss of Radix Ginseng
120 parts of 120 portions of Arillus Longans of 120 parts of Semen Ziziphi Spinosaes of Endothelium Corneum Gigeriae Galli
200 parts of 200 parts of Radix Angelicae Sinensis of 200 parts of Radixs Astragali of the Rhizoma Atractylodis Macrocephalae
200 parts of 120 parts of Radix Polygalaes of 120 portions of Rhizoma Zingiberis Recenss of Rhizoma Cyperi
120 parts in 120 portions of Radix Glycyrrhizaes of 120 parts of Radix Aucklandiae of Fructus Hordei Germinatus
2, preparation technology:
(1) Radix Ginseng 200g, Radix Astragali 200g, Radix Angelicae Sinensis 200g are with 70% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Fructus Aurantii Immaturus 200g, Poria cum Radix Pini 120g, Semen Ziziphi Spinosae 120g, Arillus Longan 120g, Rhizoma Atractylodis Macrocephalae 200g, Rhizoma Cyperi 120g, Rhizoma Zingiberis Recens 120g, Radix Polygalae 200g, Fructus Hordei Germinatus 120g, Radix Aucklandiae 120g, Endothelium Corneum Gigeriae Galli 120g, Radix Glycyrrhizae 120g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 24 hours, get supernatant, it is the thick paste of 1.20 (70 ℃) that concentrating under reduced pressure becomes relative density;
(3) step (1) gained clear paste and step (2) gained thick paste are merged add dextrin 800g mixing, drying is ground into fine powder, sieve, mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: the preparation technology of pill
1, prescription:
120 parts of 200 parts of Poria cum Radix Pinis of 200 parts of Fructus Aurantii Immaturuss of Radix Ginseng
120 parts of 120 portions of Arillus Longans of 120 parts of Semen Ziziphi Spinosaes of Endothelium Corneum Gigeriae Galli
200 parts of 200 parts of Radix Angelicae Sinensis of 200 parts of Radixs Astragali of the Rhizoma Atractylodis Macrocephalae
200 parts of 120 parts of Radix Polygalaes of 120 portions of Rhizoma Zingiberis Recenss of Rhizoma Cyperi
120 parts in 120 portions of Radix Glycyrrhizaes of 120 parts of Radix Aucklandiae of Fructus Hordei Germinatus
2, preparation technology:
(1) Radix Ginseng 200g, Radix Astragali 200g, Radix Angelicae Sinensis 200g are with 70% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Fructus Aurantii Immaturus 200g, Poria cum Radix Pini 120g, Semen Ziziphi Spinosae 120g, Arillus Longan 120g, Rhizoma Atractylodis Macrocephalae 200g, Rhizoma Cyperi 120g, Rhizoma Zingiberis Recens 120g, Radix Polygalae 200g, Fructus Hordei Germinatus 120g, Radix Aucklandiae 120g, Endothelium Corneum Gigeriae Galli 120g, Radix Glycyrrhizae 120g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 24 hours, get supernatant, it is the thick paste of 1.20 (70 ℃) that concentrating under reduced pressure becomes relative density;
(3) step (1) gained clear paste and step (2) gained thick paste are merged adding dextrin 400g mixing, drying is ground into fine powder, adds refined honey 100g, closes to stick together, and makes big honeyed pills.
Claims (5)
1, a kind of chronic gastritis Chinese medicine composition that is used for is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Ginseng 100-300 part Fructus Aurantii Immaturus 100-300 part Poria cum Radix Pini 60-180 part
Endothelium Corneum Gigeriae Galli 60-180 part Semen Ziziphi Spinosae 60-180 part Arillus Longan 60-180 part
Rhizoma Atractylodis Macrocephalae 100-300 part Radix Astragali 100-300 part Radix Angelicae Sinensis 100-300 part
Rhizoma Cyperi 60-180 part Rhizoma Zingiberis Recens 60-180 part Radix Polygalae 100-300 part
Fructus Hordei Germinatus 60-180 part Radix Aucklandiae 60-180 part Radix Glycyrrhizae 60-180 part.
2, a kind of chronic gastritis Chinese medicine composition that is used for according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
120 parts of 200 parts of Poria cum Radix Pinis of 200 parts of Fructus Aurantii Immaturuss of Radix Ginseng
120 parts of 120 portions of Arillus Longans of 120 parts of Semen Ziziphi Spinosaes of Endothelium Corneum Gigeriae Galli
200 parts of 200 parts of Radix Angelicae Sinensis of 200 parts of Radixs Astragali of the Rhizoma Atractylodis Macrocephalae
200 parts of 120 parts of Radix Polygalaes of 120 portions of Rhizoma Zingiberis Recenss of Rhizoma Cyperi
120 parts in 120 portions of Radix Glycyrrhizaes of 120 parts of Radix Aucklandiae of Fructus Hordei Germinatus.
3, according to the described a kind of chronic gastritis Chinese medicine composition that is used for of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis are with 70% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(2) Fructus Aurantii Immaturus, Poria cum Radix Pini, Semen Ziziphi Spinosae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Rhizoma Zingiberis Recens, Radix Polygalae, Fructus Hordei Germinatus, the Radix Aucklandiae, Endothelium Corneum Gigeriae Galli, Radix Glycyrrhizae decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 24 hours, and got supernatant, it is the thick paste of 1.20 (70 ℃) that concentrating under reduced pressure becomes relative density;
(3) with step (1) gained clear paste and step (2) gained thick paste mixing, drying is ground into fine powder, makes granule, capsule and pill with pharmaceutically acceptable carrier.
4, according to any one described a kind of chronic gastritis Chinese medicine composition that is used among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of chronic gastritis Chinese medicine composition that is used for of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, pill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810119842A CN101670080A (en) | 2008-09-11 | 2008-09-11 | Chinese medicinal composition for chronic gastritis and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810119842A CN101670080A (en) | 2008-09-11 | 2008-09-11 | Chinese medicinal composition for chronic gastritis and preparation process thereof |
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| CN101670080A true CN101670080A (en) | 2010-03-17 |
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| CN200810119842A Pending CN101670080A (en) | 2008-09-11 | 2008-09-11 | Chinese medicinal composition for chronic gastritis and preparation process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940862A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating recurrent vomiting caused by chronic gastritis |
| CN109846984A (en) * | 2019-04-15 | 2019-06-07 | 福州东宇生物科技有限公司 | A kind of probiotics that the multicomponent with treatment chronic gastritis function is compound |
| EP4125983A4 (en) * | 2020-04-03 | 2024-02-14 | Medihelpline Co., Ltd. | An oral pharmaceutical composition comprising an extract of combined herbs comprising longanae arillus for the treatment or alleviation of inflammatory disease and the use thereof |
-
2008
- 2008-09-11 CN CN200810119842A patent/CN101670080A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940862A (en) * | 2012-10-10 | 2013-02-27 | 肥西县中医院 | Traditional Chinese medicine for treating recurrent vomiting caused by chronic gastritis |
| CN102940862B (en) * | 2012-10-10 | 2014-04-23 | 肥西县中医院 | Traditional Chinese medicine for treating recurrent vomiting caused by chronic gastritis |
| CN109846984A (en) * | 2019-04-15 | 2019-06-07 | 福州东宇生物科技有限公司 | A kind of probiotics that the multicomponent with treatment chronic gastritis function is compound |
| EP4125983A4 (en) * | 2020-04-03 | 2024-02-14 | Medihelpline Co., Ltd. | An oral pharmaceutical composition comprising an extract of combined herbs comprising longanae arillus for the treatment or alleviation of inflammatory disease and the use thereof |
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Open date: 20100317 |