CN104324196A - Traditional Chinese medicine composition used for treating leucoderma and decoction, pill and powder thereof - Google Patents
Traditional Chinese medicine composition used for treating leucoderma and decoction, pill and powder thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition used for treating leucoderma and a decoction, a pill and a powder thereof. The traditional Chinese medicine comprises following raw materials, by weight, 40-60 parts of tribulus terrestris, 20-30 parts of polygonum multiflorum, 20-30 parts of herba ecliptae, 20-30 parts of rhizoma paridis, 20-30 parts of trichosanthes palmata, 20-30 parts of cynanchum atratum, 20-30 parts of flos carthami, 20-30 parts of dalbergia odorifera, 20-30 parts of stir-fried peach kernels, 5-15 parts of radix gentianae, 5-15 parts of cuttlebone, 5-15 parts of rhizoma atractylodis and 5-15 parts of radix glycyrrhizae. In traditional Chinese medicine composition used for treating the leucoderma, according to traditional Chinese medicine dialectical theories, the traditional Chinese medicine composition has effects of soothing liver and relieving depression, activating blood and dispelling wind, and nourishing the liver and kidney and the like, has effects of clearing liver and moving spleen, dispelling wind and freeing meridians and activating blood and resolving stasis, achieves an object of treating blood before treating the leucoderma and eliminating the leucoderma while blood moves, has significant treating effects on the leucoderma caused by deficiency of liver and kidney, and obstruction in meridians due to blood stasis, is a pure traditional Chinese medicine preparation and is less in toxic and side effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, be specifically related to one and be used for the treatment of leukodermic Chinese medicine composition, also relate to a kind of decoction, pill and the powder that adopt this Chinese medicine composition to make simultaneously.
Background technology
Vitiligo is a kind of pigment dyspoiesis dermatoses, be apt to occur in exposure portion and affect attractive in appearance, symptom is that limitation or general property depigmentation speckle appear in skin, and the melanic generation in skin lesion place reduces or disappears, and motherland's medical science is called " vitiligo ", " vitiligo ", " leucoderma " etc.This disease is about 0.5% ~ 4% in global prevalence, and China's prevalence 0.1% ~ 2.7%, and is the trend risen year by year.This disease can betide any age, within 10 ~ 30 years old, is onset peak, asexuality difference.Known tryrosinase is the key enzyme of the black pigment of skin synthesis, but leukodermic pathogenesis is still not clear, and treats still more difficult.
Ancient doctor sets forth one's views mainly with " ailment said due to cold or exposure is fought mutually, qi-blood disharmony " to the understanding of leucoderma disease because of pathogenesis.See the earliest " Prescriptions for Universal Relief ", it is thought " lung-heat Yong Sheng, ailment said due to cold or exposure takes advantage of it, and mutually also, spread battalion and defend, the stagnant muscle of harmony, does not dissipate wind heat for a long time, therefore becomes this also ".Leucoderma is waited " leucoderma person, face and neck body skin yellowish pink bleach, different from yellowish pink, pain of also not itching, the leucoderma of meaning ".Leukodermic morbidity or because of no resource of generating and transforming QI and blood caused by deficiency of the kidney yin or because of depression of liver-QI, functional activity of QI being not smooth; Or fight in the flesh natural fibre line of meat because of ailment said due to cold or exposure, disharmony between QI and blood, qi depression to blood stasis; Or because of in have damp and hot, outer by caused by ailment said due to cold or exposure.
At present, market is used for the treatment of leukodermic Western medicine primarily of glucocorticoid, calcineurin inhibitors and calcipotriol, although some medicine therapeutic effect are obvious, toxic and side effects is comparatively large, as glucocorticoid; In actual use, effect is undesirable for some medicines, has certain zest, as calcipotriol.The understanding of motherland's medical science to leucoderma disease machine mainly contains three large viewpoints, " ailment said due to cold or exposure is fought in skin; vim and vigour are got along well " of Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases ", " the vitiligo blood stasis flesh side " of Wang Qingren errors in Medicine Corrected, " weakness due to chronic disease; deficiency of both the liver and kidney " of Zhu Renkang " Surgery of Chinese Medicine ", thus form current clinical dispelling wind and removing obstruction in the collateral, liver and kidney tonifying, the large rule for the treatment of of blood circulation promoting and blood stasis dispelling three.The topmost pattern of syndrome of vitiligo is deficiency of the liver and kindey and obstruction of collaterals by blood stasis, to take orally in prescription with tonify deficiency, blood circulation promoting and blood stasis dispelling, heat clearing away medicine as many in treatment vitiligo, wherein, be main method for the treatment of mainly with nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, with depressed liver-energy dispersing and QI regulating, heat clearing away for auxiliary treatment, strengthening vital QI to eliminate pathogenic factors is held concurrently mutually, demonstrates that vitiligo is qi-blood disharmony, the etiology and pathogenesis of venation block, rheumatism intrinsic heat, illustrates that leukodermic tcm therapy has the concordance of principle-method-recipe-medicines thus.Therefore, the theory of Chinese medical science for the hepatic and renal YIN deficiency etc. carries out the new Chinese medicinal composition preparation of reasonable compatibility, can give full play to the comprehensively regulating effect of compound Chinese medicinal preparation, reaches this double curative effect controlled of leucoderma weathercock.
Summary of the invention
The object of this invention is to provide one and be used for the treatment of leukodermic Chinese medicine composition.
Second object of the present invention is to provide a kind of decoction adopting above-mentioned Chinese medicine composition to make.
3rd object of the present invention is to provide a kind of pill adopting above-mentioned Chinese medicine composition to make.
4th object of the present invention is to provide a kind of powder adopting above-mentioned Chinese medicine composition to make.
In order to realize above object, the technical solution adopted in the present invention is: one is used for the treatment of leukodermic Chinese medicine composition, comprises the component of following parts by weight: Fructus Atriplicis Sibiricae 40 ~ 60 parts, Radix Polygoni Multiflori 20 ~ 30 parts, Herba Ecliptae 20 ~ 30 parts, Rhizoma Paridis 20 ~ 30 parts, Radix Stephaniae Cepharanthae 20 ~ 30 parts, Radix Cynanchi Atrati 20 ~ 30 parts, 20 ~ 30 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 20 ~ 30 parts, Semen Persicae (parched) 20 ~ 30 parts, Radix Gentianae 5 ~ 15 parts, Endoconcha Sepiae 10 ~ 20 parts, Rhizoma Atractylodis 5 ~ 15 parts, 5 ~ 15 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the component of following parts by weight: Fructus Atriplicis Sibiricae 50 parts, Radix Polygoni Multiflori 25 parts, Herba Ecliptae 25 parts, Rhizoma Paridis 25 parts, Radix Stephaniae Cepharanthae 25 parts, Radix Cynanchi Atrati 25 parts, 25 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 25 parts, Semen Persicae (parched) 25 parts, Radix Gentianae 10 parts, Endoconcha Sepiae 15 parts, Rhizoma Atractylodis 10 parts, 10 parts, Radix Glycyrrhizae.
Described Radix Polygoni Multiflori is Radix Polygoni Multiflori Preparata.Described Rhizoma Atractylodis are Rhizoma Atractylodis processed.
Above-mentioned Chinese medicine composition can be made into the various regular dosage form of the field of Chinese medicines and takes.Preferably, described Chinese medicine composition can be made into decoction, pill or powder.
Adopt the decoction that above-mentioned Chinese medicine composition is made, this decoction is prepared by the method comprised the following steps:
1) measure Chinese medicine composition by formula, decoct with water for twice, collecting decoction;
2) get step 1) gained decocting liquid, filter, concentrated after, add ethanol, obtain mixture;
3) by step 2) the standing rear filtration of gained mixture, removing ethanol, to obtain final product.
Step 1) in, described decocting with water for twice refers to: first time adds 6 times amount (quality) water, decocts 1h after soaking 30min; Second time adds 4 times amount (quality) soak by water 40min.
Step 2) described in concentrated refer to that being concentrated into relative density is 1.15 ~ 1.20 (90 DEG C).
Step 2) mass percentage of ethanol is 65% ~ 70% in gained mixture.
Step 3) in, the described standing time is 40 ~ 56h.
Step 3) in, add purified water after removing ethanol and dilute.The addition of described purified water is: every 2 ~ 4g Chinese medicine composition correspondence adds water 1ml.
Step 3) in, also carried out sterilizing after thin up, described sterilizing is employing 100 DEG C of steam sterilization 30min.
Chinese medicine composition of the present invention, in prescription, Fructus Atriplicis Sibiricae is principal agent, and Fructus Tribuli total saponins has and improves immunity of organisms, the effect such as strong, and water extract has anti-allergic effects; Herba Ecliptae is containing saponin, vitamin A sample material; Rhizoma Paridis is containing steroidal saponin, 18 seed amino acids; Flos Carthami is containing carthamone; Radix Glycyrrhizae is containing saponin, polysaccharide, flavonoid glycoside.These are all dissolved in hot water, therefore can select the extracting method of soak by water.
Adopt the pill that above-mentioned Chinese medicine composition is made, this pill is prepared by the method comprised the following steps:
A) measure Chinese medicine composition by formula, pulverize, sieve, obtain fine powder;
B) by step a) gained fine powder mix with Mel, make honeyed pill, to obtain final product.
Step a) described in pulverize be crushed to 110 ~ 130 order fine powders.Also carried out sterilization treatment after sieving, described sterilizing is sterilization treatment 30min under 100 DEG C of conditions.
Step b) in, every 100g fine powder adds Mel 20 ~ 40g.
Described Mel is middle Mel.
Dry after making honeyed pill; Baking temperature is 50 ~ 70 DEG C.
Adopt the powder that above-mentioned Chinese medicine composition is made, this powder is made up of the method comprising the following steps:
I) measure Chinese medicine composition by formula, add water for twice reflux, extract, merge extractive liquid;
Ii) by step 1) gained extracting solution is concentrated into extractum, crushed after being dried, to obtain final product.
Step I) in, the water before described reflux, extract, Chinese medicine composition being placed in 40 ~ 60 DEG C soaks 1 ~ 3h.
Described reflux, extract, each extraction time is 1 ~ 3h.The temperature of described drying is 70 ~ 90 DEG C.
This powder is filled in capsule shells, obtains capsule.
Of the present inventionly be used for the treatment of in leukodermic Chinese medicine composition, the function of each component is as follows:
Fructus Atriplicis Sibiricae, acrid in the mouth, hardship, warm in nature; Enter liver, lung meridian.Get the effect of its dispersing the stagnated live-QI to relieve the stagnation of QI, promoting flow of QI and blood." book on Chinese herbal medicine is looked for the truth " calls it: " light weight color is white, pungent, bitter, tepor, Liver Channel ailment said due to cold or exposure of so always should faling apart.Allly see that because wind contains conjunctival congestion swells nebula, and the unbearable person of the whole body leucoderma pruritus, take this and control and invariably imitate." experimentation shows, Fructus Atriplicis Sibiricae has to melanocyte and tryrosinase the dual regulation that high concentration activates, low concentration suppresses, and in clinical practice Fructus Atriplicis Sibiricae treatment depigmentation disease application larger dose.Fructus Atriplicis Sibiricae main component is containing tribuloside, astragalin, kaempferol and a small amount of volatile oil and oil.Fructus Tribuli total saponins contained by it, by the protective effect to some enzymatic activity in blood, regulates the content of Trace Elements In Serum ferrum, copper, zinc, thus reaches the object regulating melanin to generate.Its ethanol extraction has Combination activation to tryrosinase, illustrates that it can promote the combination in the active center of substrate and tryrosinase, promotes that melanocyte produces, can improve again the activity of enzyme.
Radix Polygoni Multiflori Preparata, bitter in the mouth, warm in nature.Return liver, the heart, kidney channel.Containing than more rich emodin and chrysophanol, have effect of melanocytic propagation and tyrosinase activity outside reinforcement, Radix Polygoni Multiflori Preparata can remove ultra-oxygen anion free radical and hydroxy radical simultaneously; In intravital mouse test, find that Radix Polygoni Multiflori Preparata can improve mouse T cell quantity and function, improve microcirculation, improve the ability of anoxia enduring.Have report to confirm, single medicinal material Radix Polygoni Multiflori Preparata has comparatively significantly facilitation to melanocyte proliferation and migration, and in dose-dependence.
Herba Ecliptae, sweet in the mouth, acid, cool in nature; Return kidney channel.Tang Materia Medica is on the books to its beginning, has the merit of nourishing liver and kidney, cooling blood for hemostasis.Cure mainly deficiency of the liver and kindey; Have a dizzy spell; Early whitening of beard and hair; Spit blood; Spitting of blood etc.Herba Ecliptae has the effect of raising tryrosinase mRNA, causes murine melanoma cells B16 melanin genesis and tyrosinase activity to increase.Modern pharmacological research proves, the effects such as Herba Ecliptae also has hemostasis, protects the liver, immunomodulating, antimutagenic and anti-inflammation, and containing the flavone compound such as apigenin, luteolin, Quercetin and apigenin-7-O-glucosides and luteolin-7-O-glucosides.It is active that Herba Ecliptae flavone extract significantly can strengthen mice serum SOD, GSH-Px, reduces MDA content; And can scavenging hydroxyl and superoxide radical effectively, there is anti-oxidation function in obvious anti-radical action and body.
Rhizoma Paridis, bitter in the mouth, cold nature; Return Liver Channel.Its main chemical compositions is steroidal saponin, and containing ecdyson, polysaccharide, flavonoid glycoside and aminoacid; There is stronger physiology and pharmacologically active, comprise the effects such as antitumor, hemostasis and pain-relieving, inhibiting bacteria and diminishing inflammation, immunomodulating, be widely used in clinical.
Radix Stephaniae Cepharanthae, bitter in the mouth, cool in nature; Attach to the lung and stomach meridians.Radix Stephaniae Cepharanthae, first appeared in " Kaibao Bencao ", has effect of dissipating blood stasis, detumescence, pain relieving, heat-clearing and toxic substances removing, is used for swollen ulcer drug, parotitis, venom, treating swelling and pain by traumatic injury, pharyngalgia sore throat etc.Its main component flavone compound has remarkable result to treatment coronary heart disease, alzheimer disease, cerebral thrombosis, nervous system disease and scavenging free radicals, the aspect such as antibacterial, anticancer, has no side effect.
Radix Cynanchi Atrati is bitter in the mouth, salty, cold in nature; Return stomach, liver, kidney channel.See and be loaded in Shennong's Herbal that there is the function of clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment the earliest, for the heating of pathogenic warmth wound battalion, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug etc.It is mainly used in treatment: 1. fever due to yin deficiency; 2. pyretic stranguria stranguria with blood; 3. sore and toxic, venom, laryngopharynx swelling and pain; 4. deficiency of YIN diseases caused by exogenous pathogenic factor.Domestic and international research shows, the C in Radix Cynanchi Atrati
21steroidal saponin constituents has acetylcholine esterase inhibit activities, antiinflammatory action and anti-tumor activity.
Flos Carthami, acrid in the mouth, warm in nature; GUIXIN, Liver Channel.Be promoting blood circulation to restore menstrual flow, remove the integration of edible and medicinal herbs Chinese medicine of expectorant pain relieving.Modern pharmacology research display, main containing compositions such as Flos Carthami polysaccharide, Carthamus yellow, saffloside, flavonoid, organic acid, safflower red pigments in Flos Carthami.Experiment shows, the principle active component Flos Carthami polysaccharide of Flos Carthami has the multiple pharmacologically actives such as anticoagulation, antioxidation, blood pressure lowering, anticancer, immunomodulating, lymphocyte transformation can be promoted, increase splenocyte to the cell quantity of sheep red blood cell plaque test, the immunosuppressive action etc. of antagonism meticortelone is a kind of newly, worth immunomodulator studied further.
Lignum Dalbergiae Odoriferae, acrid in the mouth, warm in nature; Return liver, spleen channel.Lignum Dalbergiae Odoriferae function is promoting the circulation of QI to relieve pain, promoting blood circulation and hemostasis; For the firm pain in ambition, the twinge of the gastral cavity side of body; External treatment traumatic injury.The primary raw material of clinical common dosage forms as Chinese patent medicines such as GUANXIN DANSHEN PIAN, breast knot dissipation sheet, rosewood compound capsules.Show from existingization pharmacological research, Lignum Dalbergiae Odoriferae main chemical compositions is volatile oil and flavone compound.Flavone compound in Lignum Dalbergiae Odoriferae has antioxidation, anticancer, antiinflammatory, the effect such as analgesia and lax blood vessel.Volatile oil of Lignum Dalbergiae Odoriferae has anti thrombotic action, can significantly improve a Red Cell Deformability, and improves blood property by anticoagulant function.In addition, Lignum Dalbergiae Odoriferae also has the effect reducing myocardial cell interstitial I type/III collagen type ratio, improves the remodeling ventricle of myocardial infarction prognosis.Lignum Dalbergiae Odoriferae water extract also has and promotes the effect of tyrosinase activity, availablely gives therapy of vitiligo.
Semen Persicae, bitter in the mouth, sweet, property is put down; Nontoxic, enter liver, large intestine two warp.Having dredging blood vessel, dispel effect of blood stasis, is the important composition composition of all kinds of blood circulation promoting and blood stasis dispelling prescription.Li Shizhen (1518-1593 A.D.) is thought: " the easy gross weight of Semen Persicae promoting the circulation of blood, point are raw to be used; Moisturizing and invigorate blood circulation, peeling, sharp parching to brown use should be soaked for soup, or Testa Tritici is with frying, or charred medicinal herb with its property retained is respectively with we ".Therefore, raw ripe dividing is had in medical skill in ancient times.Clinically for various blood stasis symptoms such as blood stasis amenorrhea, traumatic injury.Its main chemical compositions has glycoside (amygdaloside, Virginia prune glucoside), lipid (as neutral fat, glycolipid matter, phospholipid), saccharide (glucose, sucrose etc.), protein, aminoacid, emulsin, allantoinase, quintessence oil and trace element Fe, Mn, Mg etc.In recent years, mainly the following aspects is reflected in the research of Semen Persicae function of promoting blood circulation to disperse blood clots: blood vessel dilating, increase organic blood flow volume effect, antithrombotic, improve hemorheological property effect, analgesic activity etc.
Radix Gentianae, bitter in the mouth, cold in nature; Return liver, gallbladder meridian.Function heat clearing and damp drying, eliminating pathogen in the liver is calmed the frightened.Treatment jaundice due to damp-heat, urine leaching pain, hematodiarrhoea, pain over the perineum pudendal pruritus, damp-heat vaginal discharge, conjunctival congestion pharyngalgia, deaf ear swells, hypochondriac pain bitter taste, hyperpyrexia convulsion, manic tic.Modern clinic in order to treat encephalitis B, acute ocular conjunctivitis, herpes zoster etc.Effective ingredient (being mainly gentiopicrin) in Radix Gentianae has the effects such as clearing away damp-heat, function of gallbladder promoting, stomach invigorating, sterilization, antiinflammatory, is used as bitter tonic in modern medicine.
Endoconcha Sepiae, salty in the mouth, puckery, slightly warm in nature; Return liver, kidney channel.There is effect for the treatment of spontaneous emission and leukorrhagia, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Compendium of Material Medica record, Endoconcha Sepiae has various astriction, clinical practice in treatment multiple interior external haemorrhage, gastroduodenal ulcer, part chronic gastritis, also for the treatment of skin ulcer, decubital ulcer etc.; " herbal classic " is recorded, and Endoconcha Sepiae " can control woman's multicoloured leukorrhagia "; " solar corona all book on Chinese herbal medicine " is recorded, and Endoconcha Sepiae can " treatment metrorrhagia ", therefore is clinically also applied to various gynecological diseases.
Rhizoma Atractylodis, sweet in the mouth, hardship, warm in nature; Return spleen, kidney, Liver Channel.Principle active component Rhzoma Atractylodis Lanceae volatile oil in Rhizoma Atractylodis, excessively shows obvious side effect to human body, and the traditional Chinese medical science is referred to as " dry property ".Take suitable method to carry out concocting (Rhizoma Atractylodis processed), drive away its " dry property ".There is effect of drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Be mainly used in distension and fullness in the abdomen, have loose bowels, inappetence, edema, beriberi flaccidity syndrome and arthralgia syndrome, anemofrigid cold, the diseases such as nyctalopia nyctalopia.Modern pharmacological research shows, Rhizoma Atractylodis have multiple effect to digestive system, can also protect the liver, blood sugar lowering, antibacterial, antiviral etc.
Radix Glycyrrhizae, sweet in the mouth, property is put down; Enter spleen, stomach, lung meridian.Primary efficacy is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Modern pharmacological research proves, Radix Glycyrrhizae agent has the function of antiinflammatory and antiallergic action, therefore in doctor trained in Western medicine clinically mainly as demulcent; Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.
Of the present inventionly be used for the treatment of leukodermic Chinese medicine composition, with heavy dose of Fructus Atriplicis Sibiricae with dispersing the stagnated live-QI to relieve the stagnation of QI, invigorate blood circulation, dispel the wind and take as the leading factor; Be equipped with Herba Ecliptae, Radix Polygoni Multiflori Preparata with nourishing the liver and kidney, boosting qi and nourishing yin; Assistant is with Radix Gentianae, Rhizoma Atractylodis processed, Endoconcha Sepiae with liver heat removing activating the spleen, and dehumidify sore; Radix Stephaniae Cepharanthae, Rhizoma Paridis, Radix Cynanchi Atrati with heat-clearing and toxic substances removing, dispelling wind and removing obstruction in the collateral; Adding Lignum Dalbergiae Odoriferae, Semen Persicae (parched), Flos Carthami with loose wind, the blood circulation promoting and blood stasis dispelling of regulating the flow of vital energy, reaching the object of " control wind and first control blood, blood wind is from going out "; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making.According to another report, Fructus Atriplicis Sibiricae has hyperchromic effect.Each like this taste medicine is mutual harmonizing in vivo, regulates spirit nerve and immunologic function, plays effect of blood circulation promoting and blood stasis dispelling, loose gas in fashion, kidney-replenishing blood-nourishing altogether, increases pigment cell's regeneration capacity, promote pigment cell's chromogenesis, have significant curative effect for vitiligo.
Of the present inventionly be used for the treatment of leukodermic Chinese medicine composition, Fructus Atriplicis Sibiricae, Radix Polygoni Multiflori Preparata, Herba Ecliptae, Rhizoma Paridis, Radix Stephaniae Cepharanthae, Radix Cynanchi Atrati, Flos Carthami, Lignum Dalbergiae Odoriferae, Semen Persicae (parched), Radix Gentianae, Endoconcha Sepiae, Rhizoma Atractylodis processed, Radix Glycyrrhizae is adopted to carry out composite, traditionally differential diagnosis in tcm is theoretical, except dispersing the stagnated live-QI to relieve the stagnation of QI, invigorate blood circulation, dispel the wind, outside the effect such as nourishing the liver and kidney, also can liver heat removing activating the spleen, dispelling wind and removing obstruction in the collateral, blood circulation promoting and blood stasis dispelling, reach the object of " control wind and first control blood; blood wind is from going out ", have significant therapeutic effect to the vitiligo caused by deficiency of the liver and kindey, obstruction of collaterals by blood stasis; For pure Chinese medicinal preparation, do not add any chemicals, long-term taking toxic and side effects is little; Action temperature and, patient is implemented to tune, controls combination, its metabolism and endocrine are carried out in order, thus achieve leukodermic basic treatment.
Decoction, pill or powder that the above-mentioned Chinese medicine composition of employing of the present invention is made, by decocting, pulverizing or the mode of reflux, extract, makes certain dosage form, improve the stability of medicine, be applicable to large-scale production and long term storage; These dosage forms are carried and taking convenience, improve the compliance of patient.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1
The present embodiment be used for the treatment of leukodermic Chinese medicine composition, comprise the component of following parts by weight: Fructus Atriplicis Sibiricae 50 parts, Radix Polygoni Multiflori Preparata 25 parts, Herba Ecliptae 25 parts, Rhizoma Paridis 25 parts, Radix Stephaniae Cepharanthae 25 parts, Radix Cynanchi Atrati 25 parts, 25 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 25 parts, Semen Persicae (parched) 25 parts, Radix Gentianae 10 parts, Endoconcha Sepiae 15 parts, Rhizoma Atractylodis processed 10 parts, 10 parts, Radix Glycyrrhizae.
The decoction that the above-mentioned Chinese medicine composition of employing of the present embodiment is made is prepared by the method comprised the following steps:
1) measure Chinese medicine composition by formula, add the water of 6 times amount for the first time, decoct 1h after soaking 30min, get decocting liquid; Second time adds the soak by water 40min of 4 times amount, collecting decoction;
2) step 1 is got) gained decocting liquid, filter, being concentrated into relative density is 1.17 (90 DEG C), and add ethanol, obtain mixture, in mixture, the mass percentage of ethanol is 65%;
3) by step 2) gained mixture is after 4 DEG C of cold preservations, leaving standstill 48h, and filtration, after getting filtrate removing ethanol (recovery), add purified water to dilute, the addition of described purified water is that every 3g Chinese medicine composition correspondence adds water 1ml, filters, subpackage, to obtain final product.
The specification of described decoction is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 10 ~ 20ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Embodiment 2
The present embodiment be used for the treatment of leukodermic Chinese medicine composition, comprise the component of following parts by weight: Fructus Atriplicis Sibiricae 50 parts, Radix Polygoni Multiflori Preparata 25 parts, Herba Ecliptae 25 parts, Rhizoma Paridis 25 parts, Radix Stephaniae Cepharanthae 25 parts, Radix Cynanchi Atrati 25 parts, 25 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 25 parts, Semen Persicae (parched) 25 parts, Radix Gentianae 10 parts, Endoconcha Sepiae 15 parts, Rhizoma Atractylodis processed 10 parts, 10 parts, Radix Glycyrrhizae.
The pill that the above-mentioned Chinese medicine composition of employing of the present embodiment is made is prepared by the method comprised the following steps:
A) measure Chinese medicine composition by formula, be crushed to 120 orders, sieve, sterilization treatment 30min under 100 DEG C of conditions, obtains fine powder;
B) add middle Mel 30g by every 100g fine powder, by step a) gained fine powder mix with middle Mel, be heated to 70 DEG C and add certain amount of boiling water mixing, make the honeyed pill of every heavily about 0.3g, 60 DEG C of dryings, to obtain final product.
The specification of this pill is 0.3g/ grain.Usage and dosage: oral, 3 times on the one, one time 4.
Embodiment 3
The present embodiment be used for the treatment of leukodermic Chinese medicine composition, comprise the component of following parts by weight: Fructus Atriplicis Sibiricae 50 parts, Radix Polygoni Multiflori Preparata 25 parts, Herba Ecliptae 25 parts, Rhizoma Paridis 25 parts, Radix Stephaniae Cepharanthae 25 parts, Radix Cynanchi Atrati 25 parts, 25 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 25 parts, Semen Persicae (parched) 25 parts, Radix Gentianae 10 parts, Endoconcha Sepiae 15 parts, Rhizoma Atractylodis processed 10 parts, 10 parts, Radix Glycyrrhizae.
The powder that the above-mentioned Chinese medicine composition of employing of the present embodiment is made is prepared by the method comprised the following steps:
I) measure Chinese medicine composition by formula, the water being placed in 50 DEG C soaks 2h, is placed in extractor, reflux, extract, twice, each 2h, merge extractive liquid;
Ii) by step 1) gained extracting solution is concentrated into extractum, crushed after being dried under 80 DEG C of conditions, and cross 100 mesh sieves, microwave sterilizating, to obtain final product.
This powder is filled in capsule shells, subpackage, obtains capsule.
Specification 0.33g × 60/bottle of this capsule.Usage and dosage: oral, 2 times on the one, one time 5.
Embodiment 4
The present embodiment be used for the treatment of leukodermic Chinese medicine composition, comprise the component of following parts by weight: Fructus Atriplicis Sibiricae 40 parts, Radix Polygoni Multiflori Preparata 30 parts, Herba Ecliptae 20 parts, Rhizoma Paridis 20 parts, Radix Stephaniae Cepharanthae 30 parts, Radix Cynanchi Atrati 30 parts, 20 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 30 parts, Semen Persicae (parched) 20 parts, Radix Gentianae 15 parts, Endoconcha Sepiae 20 parts, Rhizoma Atractylodis processed 5 parts, 15 parts, Radix Glycyrrhizae.
The decoction that the above-mentioned Chinese medicine composition of employing of the present embodiment is made is prepared by the method comprised the following steps:
1) measure Chinese medicine composition by formula, add the water of 5 times amount for the first time, decoct 0.5h after soaking 20min, get decocting liquid; Second time adds the soak by water 50min of 5 times amount, collecting decoction;
2) step 1 is got) gained decocting liquid, filter, being concentrated into relative density is 1.15 (90 DEG C), and add ethanol, obtain mixture, in mixture, the mass percentage of ethanol is 70%;
3) by step 2) the 4 DEG C of cold preservations of gained mixture, to leave standstill after 40h, filter, after getting filtrate removing ethanol (recovery), add purified water to dilute, the addition of described purified water is: every 2g Chinese medicine composition correspondence adds water 1ml, filters, subpackage, to obtain final product.
The specification of described decoction is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 10 ~ 20ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Embodiment 5
The present embodiment be used for the treatment of leukodermic Chinese medicine composition, comprise the component of following parts by weight: Fructus Atriplicis Sibiricae 60 parts, Radix Polygoni Multiflori Preparata 20 parts, Herba Ecliptae 30 parts, Rhizoma Paridis 30 parts, Radix Stephaniae Cepharanthae 20 parts, Radix Cynanchi Atrati 20 parts, 30 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 20 parts, Semen Persicae (parched) 30 parts, Radix Gentianae 5 parts, Endoconcha Sepiae 10 parts, Rhizoma Atractylodis processed 15 parts, 5 parts, Radix Glycyrrhizae.
The decoction that the above-mentioned Chinese medicine composition of employing of the present embodiment is made is prepared by the method comprised the following steps:
1) measure Chinese medicine composition by formula, add the water of 7 times amount for the first time, decoct 1.5h after soaking 40min, get decocting liquid; Second time adds the soak by water 30min of 3 times amount, collecting decoction;
2) step 1 is got) gained decocting liquid, filter, being concentrated into relative density is 1.20 (90 DEG C), and add ethanol, obtain mixture, in mixture, the mass percentage of ethanol is 68%;
3) by step 2) the 4 DEG C of cold preservations of gained mixture, to leave standstill after 56h, filter, after getting filtrate removing ethanol (recovery), add purified water to dilute, the addition of described purified water is: every 4g Chinese medicine composition correspondence adds water 1ml, filters, subpackage, to obtain final product.
The specification of described decoction is 250ml/ bottle.Usage and dosage: oral, 3 times on the one, a 10 ~ 20ml.Take in process and should be careful in one's diet, avoid cold and uncooked food, greasy, pungent.
Experimental example
This experimental example is used for the treatment of leukodermic Chinese medicine composition to embodiment 1 gained and carries out clinical observation on the therapeutic effect.
For checking embodiment 1 gained is used for the treatment of the therapeutic effect of leukodermic Chinese medicine composition, carried out efficiency assay in The First Affiliated Hospital of Henan University of Science and Technology, clinical test results is as follows:
1. physical data
(1) Disease Diagnosis Standard:
Leukodermic diagnostic criteria is with reference to " clinical dermatology " of being distinguished chief editor by Zhao; Clinical typing is with reference to CAIM's Dermatology Professional Committee pigment disease group vitiligo Clinical typing and criterion of therapeutical effect (revised draft in 2003): skin lesion color bleaches, and shape differs, or speckle or point, without sufferings.Health can be occurred in everywhere, common with women's head-ornaments, extremity.Tissue pathology checking's display epidermis obviously lacks melanocyte and melanin granule, and basal layer often lacks the melanocyte of the dopa stain positive completely.
TCM syndrome diagosis according to " tcm symptom Differential Diagnosis ", and is controlled typing experience work out with reference to Zhu Guangdou, the identical traditional Chinese medical science of Ouyang, the leukodermic card of combination of Chinese and Western medicine dermatologist:
Wind blood is rich card mutually: primary symptom: 1. skin lesion is milky white or pink, and 2. boundary owes clear, and the development of urgency of 3. falling ill, white macula is very fast, is 4. more common in face and exsertion part, 5. often has scratchiness before whiteness of skin, bring out white macula medical history after 6. having wound.Secondary disease: 1. in the majority with person between twenty and fifty, 2. light red tongue tongue is white or yellow, 3. stringy pulse or floating number.
Liver depression and Qi stagnation: primary symptom: bright time 1. dark during white macula color and luster, 2. without fixing predilection site, 3. often to increase the weight of with the fluctuation of emotion, 4. can accompany depressed emotion, happiness sighs or susceptible to lose temper due to restlessness, 5. the breast side of body or few abdominal distention is vexed alters pain, 6. stringy pulse.Secondary disease: 1. female breast distending pain, dysmenorrhea, menoxenia, 2. insomnia and dreamful sleep, 3. light red tongue white and thin fur.
Syndrome of yin deficiency of liver and kidney: primary symptom: 1. color is pure white, 2. or be confined to a place, or general in everywhere, 3. in decolouring speckle, hair is in vain variable, and 4. the course of disease is longer, slower development, therapeutic effect is not remarkable, 5. family history time disease is had: 1. soreness of the waist and knees, 2. xerostomia, 3. night sweat, 4. insomnia and dreamful sleep, 5. dysphoria with feverish sensation in the chest palms and soles, 6. red tongue, few tongue, stringy,thready and rapid pulse.Possesses above primary symptom 3 and above or primary symptom 2 merges time disease 2 and above person, this syndrome diagnosable.
(2) inclusive criteria
Meet Western medicine diagnose standard; Meet TCM syndrome diagnostic criteria; Age is between 18 ~ 65 years old; Signature Informed Consent Form person.
(3) case exclusion standard
Get rid of following patient: 1. affected part is accompanied with other dermatosis patients evaluated that may obviously affect the treatment; 2. the serious heart, Liver and kidney function impairer; 3. there is photosensitive diseases or have cataract medical history person, gestation and breast-feeding female; 4. skin carcinoma medical history person is had; 5. treating in first 1 month in use this method used the leukodermic medicine person of any treatment and treatments period arbitrarily stop treatment or change medicine, method person; 6. the infull person of non-completed treatment and data.
2. divide into groups
82 routine patients are all from this Out-patient Department, and wherein man 32 example, female 50 is routine, 10 ~ 48 years old age, average 27 years old.The course of disease 3 months ~ 10 years, average course of disease 2.8 years.Topical type 43 example, distributes type 15 example, general hair style 10 example, acra type 6 example, segmental pattern 8 example; Resting stage 56 is routine, and progressive stage 26 is routine.The diagnosis of all patients all meets the fixed diagnostic criteria of national combination of Chinese and Western medicine Society of Dermatology and Venereology pigment disease length of schooling.
3. research method
Adopt randomized patient to be divided into matched group 46 example and treatment group 36 example, treatment group adopts embodiment 1 gained decoction, oral, a 10 ~ 20ml, 3 times on the one; Matched group is oral vifiligo pill (commercial goods) 6 only, every day 2 times.Further consultation 1 time in all every 2 weeks, observe the curative effect and untoward reaction, 3 months total courses for the treatment of.
4. curative effect determinate standard
Clinical typing about vitiligo and criterion of therapeutical effect is organized with reference to national combination of Chinese and Western medicine Society of Dermatology and Venereology pigment disease.
According to the vitiligo criterion of therapeutical effect (draft) that national combination of Chinese and Western medicine Society of Dermatology and Venereology pigmented dermatosis group is formulated, be divided into recovery from illness, effective, improvement, invalid 4 grades.Recovery from illness: white macula all disappears, skin recovers normal skin tone; Effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion area >=50%; Take a turn for the better: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion area 10% ~ 49%; Invalid: white macula non-pigment regenerates, the area recovering normal skin tone accounts for skin lesion area < 10%.Effective percentage=(recovery from illness case+effective case)/total case load × 100%.
5. result of study
After treating 4 weeks, treatment group is fully recovered 9 examples (18.75%), total effective rate 62.5%; Matched group is fully recovered 4 examples (10%), total effective rate 33.33%, two groups of similar (χ of cure rate
2=0.38, P>0.05), and total effective rate difference has statistical significance (χ
2=5.274, P<0.05).After treating 12 weeks, two groups of cure rates and effective percentage all rise, and two groups of cure rate still zero difference (χ
2=0.389, P>0.05), but total effective rate difference has statistical significance (χ
2=4.403, P<0.05), in table 1,2.
Table 1 liang group treatment Clinical efficacy comparison [example (rate), n (%)] after 4 weeks
Note: compare χ between group
2=5.274, P<0.05.
Table 2 liang group treatment Clinical efficacy comparison [example (rate), n (%)] after 12 weeks
Note: compare χ between group
2=4.403, P<0.05.
6. conclusion
By taking embodiment 1 gained decoction treatment vitiligo, total effective rate is 81.25%, apparently higher than 56.67% (χ of matched group
2=4.403, P<0.05), and there is not the untoward reaction such as hepatic and renal function injure, show that Chinese medicine composition curative effect of the present invention is certainly, has good safety.
Model case
Model case 1: what ×× of In Luoning, Henan county, man, 33 years old.The both hands back of the body, trunk number place whiteness of skin was found after heavy cold before 5 years; No conscious sympton, later leukoderma expands gradually, increases, melts platform, is diagnosed as vitiligo.Once adopted many kinds of force method therapeutic effect not good.Without vitiligo medical history in family.Department of dermatologry checks: the visible 1 ~ l0cm of face, trunk, extremity differs in size, out-of-shape, well-defined depigmentation speckle, white macula smooth surface, and its surrounding skin pigment is deepened, and is diagnosed as vitiligo.After the decoction that the Chinese medicine composition taking the embodiment of the present invention 1 obtains, white macula major part disappears, and recovers normal skin tone.Continue with the after treatment of this medicine, do not increase the weight of further so far.
Model case 2: Henan Yichuan County king ××, 34 years old.Because lower jaw part depigmentation is gone to a doctor.Before patient is about half a year there is depigmentation speckle, no conscious sympton in lower jaw palpus portion.Patient before 1 year ultrasound diagnosis find proliferation (suspected of thyroid adenoma) in thyroid, do not treat so far, without other system history of disease.Without vitiligo medical history in sufferers themselves and kinsfolk.Department of dermatologry checks: lower jaw part is shown in that 3 places are about that l angle coin is large, the irregular depigmentation speckle of form.Clear border. without squama on it.Other positions of eyebrow, hair and trunk are without similar change.After the pill that the Chinese medicine composition taking the embodiment of the present invention 2 obtains, white macula reduces, pigment hypertrophy, and rear continuation takes, and does not recur so far and increases the weight of.
Model case 3: Luoyang, henan city poplar ××, 32 years old.Because right face depigmentation speckle is gone to a doctor for 3 years.Patient before 3 years right face there is depigmentation speckle, do not cause patient to pay attention to, later leukoderma expands gradually, increases, melts platform.Patient before there is depigmentation speckle skin without pruritus, also without wound.Patient's private prosecution premorbid half a year feels out of one's plate because of problem concerning life, once medically in outer court gives multiple treatment, and comprise Halometasone Cream and methoxsalen solution, subjective effect is not good enough.Patient is previously healthy, without patients with vitiligo in family.Physical examination: systems inspection no abnormality seen.Department of dermatologry checks: right forehead, ULRE and upper right lip lamellar depigmentation speckle, and depigmentation speckle is all no more than human body center line, visible 3 the little depigmentation speckles of right side cheek, not of uniform size.Be diagnosed as vitiligo.After the capsule that the Chinese medicine composition taking the embodiment of the present invention 3 obtains, white macula does not expand further and increases, and depigmentation speckle disappears, and 70% recovers normal skin tone, and rear continuation takes this medicine, does not recur further so far and increases the weight of.
Model case 4: the yellow ×× in Ruyang, henan Province county, 23 years old.Veal skin expands more than 2 years gradually.Have a medical check-up: white macula after other, the right cheek of right side forehead, nose, right cervical region, ear, is dispersed in distribution, partial fusion.Right side eyebrow, eyelashes color are white.Skin lesion does not exceed center line.Like angry, side of body rib in right side is uncomfortable once in a while, and right leg takes out pain once in a while, dreaminess, and stool is not smooth, and menstrual cycle rule, amount are few, remaining without uncomfortable.Pale tongue with white fur is greasy, deep-thready pulse.Previously treatment: oral fair and clear granule and epidermis transfer factor capsule, narrow-band UVB irradiates, and external Tacrolimus paste etc., all without obvious curative effects.After the decoction that the Chinese medicine composition taking the embodiment of the present invention 4 obtains, there is point-like pigmentation in white macula after neck, nose, right leukoma range shorter, sleep amelioration, remaining without uncomfortable.After continue to take this medicine, right cheek, nose white macula disappear substantially, and after forehead and neck, white macula obviously reduces, and part scatter, and the blackening of right eyelid hair part, menstrual blood volume increases to some extent, and right side Somatic discomfort symptom is not reaccessed.
Model case 5: ×× is opened in Mengjin County, Henan, 10 years old.Abdominal part depigmentation speckle 2 years.Many hospital diagnosis are vitiligo, irregular oral and external medication is invalid (specifically not quite clear).Department of dermatologry checks: distribute outside Right Lower Abdomen to thigh root the depigmentation speckle differed in size, and patch merges mutually, clear border, is dispersed in point-like pigment island in part white macula.Diagnosis: vitiligo, topical type.After taking the obtained decoction of the Chinese medicine composition of the embodiment of the present invention 5, have comparatively polychrom island to occur in white macula, the scope of white macula significantly reduces, continued treatment after 4 months former white macula pigment substantially recover normal.Follow up a case by regular visits to 6 months without recurrence.
Claims (10)
1. be used for the treatment of a leukodermic Chinese medicine composition, it is characterized in that: the component comprising following parts by weight: Fructus Atriplicis Sibiricae 40 ~ 60 parts, Radix Polygoni Multiflori 20 ~ 30 parts, Herba Ecliptae 20 ~ 30 parts, Rhizoma Paridis 20 ~ 30 parts, Radix Stephaniae Cepharanthae 20 ~ 30 parts, Radix Cynanchi Atrati 20 ~ 30 parts, 20 ~ 30 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 20 ~ 30 parts, Semen Persicae (parched) 20 ~ 30 parts, Radix Gentianae 5 ~ 15 parts, Endoconcha Sepiae 10 ~ 20 parts, Rhizoma Atractylodis 5 ~ 15 parts, 5 ~ 15 parts, Radix Glycyrrhizae.
2. be according to claim 1ly used for the treatment of leukodermic Chinese medicine composition, it is characterized in that: the component comprising following parts by weight: Fructus Atriplicis Sibiricae 50 parts, Radix Polygoni Multiflori 25 parts, Herba Ecliptae 25 parts, Rhizoma Paridis 25 parts, Radix Stephaniae Cepharanthae 25 parts, Radix Cynanchi Atrati 25 parts, 25 parts, Flos Carthami, Lignum Dalbergiae Odoriferae 25 parts, Semen Persicae (parched) 25 parts, Radix Gentianae 10 parts, Endoconcha Sepiae 15 parts, Rhizoma Atractylodis 10 parts, 10 parts, Radix Glycyrrhizae.
3. the decoction adopting Chinese medicine composition as claimed in claim 1 to make, is characterized in that: this decoction is prepared by the method comprised the following steps:
1) measure Chinese medicine composition by formula, decoct with water for twice, collecting decoction;
2) get step 1) gained decocting liquid, filter, concentrated after, add ethanol, obtain mixture;
3) by step 2) the standing rear filtration of gained mixture, removing ethanol, to obtain final product.
4. decoction according to claim 3, is characterized in that: step 1) in, described decocting with water for twice refers to: first time adds 5 ~ 7 times of water gagings, decocts 0.5 ~ 1.5h after soaking 20 ~ 40min; Second time adds 3 ~ 5 times amount soak by water 30 ~ 50min.
5. decoction according to claim 3, is characterized in that: step 2) mass percentage of ethanol is 65% ~ 70% in gained mixture.
6. the pill adopting Chinese medicine composition as claimed in claim 1 to make, is characterized in that: this pill is made up of the method comprising the following steps:
A) measure Chinese medicine composition by formula, pulverize, sieve, obtain fine powder;
B) by step a) gained fine powder mix with Mel, make honeyed pill, to obtain final product.
7. pill according to claim 6, is characterized in that: step b) in, every 100g fine powder adds Mel 20 ~ 40g.
8. the powder adopting Chinese medicine composition as claimed in claim 1 to make, is characterized in that: this powder is made up of the method comprising the following steps:
I) measure Chinese medicine composition by formula, add water for twice reflux, extract, merge extractive liquid;
Ii) by step 1) gained extracting solution is concentrated into extractum, crushed after being dried, to obtain final product.
9. powder according to claim 8, is characterized in that: step I) in, the water before described reflux, extract, Chinese medicine composition being placed in 40 ~ 60 DEG C soaks 1 ~ 3h.
10. powder according to claim 8, is characterized in that: incapsulate in shell by this powder, obtain capsule.
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| CN201410402838.3A CN104324196A (en) | 2014-08-15 | 2014-08-15 | Traditional Chinese medicine composition used for treating leucoderma and decoction, pill and powder thereof |
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| CN201410402838.3A CN104324196A (en) | 2014-08-15 | 2014-08-15 | Traditional Chinese medicine composition used for treating leucoderma and decoction, pill and powder thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748613A (en) * | 2016-04-15 | 2016-07-13 | 宁波优美科新材料有限公司 | Drug for treating vitiligo |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124636A (en) * | 1994-12-16 | 1996-06-19 | 陈秋林 | Wulong Qubai powder |
| KR101416454B1 (en) * | 2011-09-23 | 2014-07-09 | (주)제주사랑농수산 | Composition for the Improvement of Leukoderma Using an Extract of Chrysanthemum indicum |
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2014
- 2014-08-15 CN CN201410402838.3A patent/CN104324196A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1124636A (en) * | 1994-12-16 | 1996-06-19 | 陈秋林 | Wulong Qubai powder |
| KR101416454B1 (en) * | 2011-09-23 | 2014-07-09 | (주)제주사랑농수산 | Composition for the Improvement of Leukoderma Using an Extract of Chrysanthemum indicum |
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| 孟晓丹: "生肌祛白合剂的制备及质量标准", 《中国民间疗法》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105748613A (en) * | 2016-04-15 | 2016-07-13 | 宁波优美科新材料有限公司 | Drug for treating vitiligo |
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Application publication date: 20150204 |