CN108936665A - A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof - Google Patents
A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof Download PDFInfo
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- CN108936665A CN108936665A CN201810931263.2A CN201810931263A CN108936665A CN 108936665 A CN108936665 A CN 108936665A CN 201810931263 A CN201810931263 A CN 201810931263A CN 108936665 A CN108936665 A CN 108936665A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of compositions of enriching yin and nourishing kidney, it is prepared using the raw material for including following ingredient: American Ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and Radix Glycyrrhizae, the amount ratio of the present invention American Ginseng, Radix Astragali and coconut albumen preferably wherein is in (1~6): (2~12): in the range of (0.5~7).Composition provided by the invention can be used for preparing the food or health care product of enriching yin and nourishing kidney, can be also used for the drug of preparation prevention or treatment constipation.The raw material sources safety that scheme provided by the invention uses, preparation method is simple, using the different medical mechanism of each ingredient, the synergistic function between each ingredient is given full play to, can be achieved at the same time and kidney is supported to women enriching yin, improves immunity, the effect of relax bowel and defecation and anti-aging.
Description
Technical field
The present invention relates to functional food fields, and in particular to a kind of composition of enriching yin and nourishing kidney.
Background technique
With the raising of people's material and cultural life, more and more people start focus on health, health care and beauty etc.,
And they have recognized that the serious side effects of chemically drug, start to return to traditional Chinese medicine.The kidney being the origin of congenital constitution, and kidney has
The raw marrow of main bone, store essential substances receive the function of gas.Due to the influence of people's bad life habits such as stay up late work, all night play, night sheet
It should fall asleep and egersis, sun should enter yin and float on outside, cause sun not enter the long yin of yin, yang and disappear, and cause yin-fluid consumption in kidney excessive, out
The performance that existing kidney yin leaks back skin zone fat secretion of such as staying up late is excessive, and the performance of kidney yin not checking exuberance of yang gets angry after such as staying up late, gum
Redness, acne etc., cause fecundity to decline increasingly.Women easily occur paramenia, Tidal fever with perspiration, amnesia insomnia, loose stool or
Constipation, emotional, tired etc..
With the influence of the change of people's dietary structure and psychiatric and social factor, constipation disease incidence, which has to increase, to become
Gesture.Illness rate of the constipation in crowd is up to 27%, can influence the people of each age group.Since constipation is a kind of more universal
Symptom, symptoms of varying severity, most people usually do not go special to comprehend, it is believed that constipation is not disease, does not have to treatment, but actually just
Secret harm is very big.Constipation some diseases such as colon cancer, hepatic encephalopathy, mammary gland disease, alzheimer's disease generation in lifting
It acts on, this respect has many research reports；Constipation can lead to life accident in acute myocardial infarction AMI, cerebrovascular accident patient,
There are many painful example let us vigilance；Part constipation and anorectal disease, such as hemorrhoid, anal fissure have close relationship.
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter of the external intrusion of elimination are (viral, thin
Bacterium etc.), handle the own cells of aging, damage, death, denaturation, and identification and processing vivo mutations cell and virus infection
The ability of cell is human bioequivalence and the physiological reaction for excluding " dissident ".
Aging refer to body the physiology and psychological fitness progressive of environment are reduced, gradually phenomenon deathward.
With social development, people increasingly pay close attention to for pursuing beauty in daily life, and aging is the irresistible natural law,
Delay senescence also more and more attention has been paid to.Drug anti-aging often brings certain side effect, and health food is gradually by people
Approved.
There is presently no the productions that can be directed to the feeding kidney of women enriching yin, improve immunity and relax bowel and defecation, anti-aging
Product.Existing product is mostly simple function product, and in the majority with the drug of one-component, and side effect is strong, should not be taken for a long time.
Summary of the invention
It is an object of the invention to overcome the deficiencies of existing technologies, a kind of composition of enriching yin and nourishing kidney is provided.The composition
The materials safety of use, preparation method is simple, and can be achieved at the same time logical to the feeding kidney of women enriching yin, raising immunity, ease constipation
Just and delay senescence effect.
Specifically, the composition of enriching yin and nourishing kidney provided by the invention uses the raw material including following ingredient to be prepared:
American Ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and Radix Glycyrrhizae.
Wherein the weight ratio of American Ginseng, Radix Astragali and coconut albumen is preferably (1~6): (2~12): (0.5~7)；
More preferably (2~6): (7~12): (1~5).
The American Ginseng that the present invention uses is Araliaceae Panax herbs perennial vegetation, alias American ginseng, American ginseng, Westerner
Ginseng can enhance central nervous system function, protection cardiovascular system, improve immunity, treatment diabetes, tonifying lung fall fire, nourishing the stomach
It promotes the production of body fluid.
The dendrobium candidum that the present invention uses is orchid family herbaceous plant, sweet in flavor, cold nature, have promoting fluid production and nourishing stomach, nourishing Yin and clearing heat,
The effect of moistening lung kidney-nourishing, improving eyesight strong waist.
The Radix Astragali that the present invention uses is the root of leguminous mongolian scutellaria.Radix Astragali can be with invigorating qi for strengthening superficies, pus draining and toxin expelling, benefit
Urine, myogenic are generally used for deficiency of vital energy and acking in strength, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, sore
The long disunion of mouth.
For the coconut albumen that the present invention uses for the endosperm of babassu coconut, endosperm kills tapeworm effect, drink its juice and
Shiqi meat can expelling parasite, control in QI invigorating, remove wind.
The radix polygonati officinalis that the present invention uses has yin-nourishing, moisturizes, heat-clearing, promotes the production of body fluid, cough-relieving etc. for Liliaceae herbaceos perennial
Effect.Radix polygonati officinalis is typically used as tonic, cures mainly the diseases such as consumption of YIN caused by febrile disease, abnormal heat cough caused by dryness, heart disease, diabetes, tuberculosis, and can
Make high-grade nourishing food, delicacies and beverage, it is with health role.
The Radix Glycyrrhizae that the present invention uses is the dry root of glycyrrhizic legume, swollen fruit Radix or glycyrrhiza glabra and rhizome.Radix Glycyrrhizae
It is sweet in flavor, it is mild-natured, enter return heart, lung, spleen, stomach meridian, there is anti-aging, anti-inflammatory, antiviral, decompression, enhancing immunity of organisms, improve life
It manages function, inhibit the effects of growth of cancer cells.
The raw material that the present invention is used to prepare enriching yin and nourishing kidney composition is safe to the human body, environmentally friendly, and there is
Different pharmacological actions.The present invention selects boosting qi and nourishing yin, and the American Ginseng of clearing heat and promoting fluid is helped with tonifying Qi and lifting yang, the Huang of shengjin nourishing
Stilbene is as monarch drug in a prescription；The radix polygonati officinalis that nourishing Yin and clearing heat, the dendrobium candidum of reinforcing stomach reg fluid and nourishing yin to moisten dryness promote the production of body fluid to quench thirst is ministerial drug；Cooperate QI invigorating
The coconut albumen for removing wind is adjutant, is invigorated the spleen and benefited qi, and clearing heat and detoxicating Radix Glycyrrhizae is to make medicine, with coordinating the drug actions of a prescription.These types of ingredient is carried out
Compatibility is used in combination, and can play synergistic effect, and being embodied in the composition, to can be achieved at the same time raising immune
The effect of power, enriching yin and nourishing kidney, relax bowel and defecation and anti-aging.
The present invention for people of weak constitution using a large amount of American Ginseng and Radix Astragali in practice, it has been found that easily occurred
The case where " void is not mended ", and lead to that good curative effect cannot be generated；But above lack can be improved by introducing this component of coconut albumen
It falls into.Since coconut albumen enters lung, the spleen channel, the effect of taking it to replenish qi to invigorate the spleen, reconciles and grows greasy tonic pharmacological property in prescription, alleviates tonic shape
The symptom of Cheng Zhongman improves the defect that tonic void is not mended.The present invention is by largely practice discovery, when American Ginseng, Radix Astragali and coconut palm
The weight ratio of sub- flesh is in (1~6): (2~12): (0.5~7), more preferably (2~6): (7~12): in the range of (1~5)
When, the effect of optimal synergy can be played between each component.
As a preferred solution of the present invention, the composition of the enriching yin and nourishing kidney, in parts by weight, using including following ingredient
Raw material be prepared:
Preferably, the composition uses the raw material including following ingredient to be prepared:
It is highly preferred that the composition uses the raw material including following ingredient to be prepared:
In above-mentioned preferred embodiment, the weight ratio of American Ginseng, Radix Astragali and coconut albumen is in (1~6): (2~12): (0.5~7),
More preferably (2~6): (7~12): in the range of (1~5).
As a preferred solution of the present invention, the composition of the enriching yin and nourishing kidney be with the American Ginseng of above-mentioned dosage part,
Dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and Radix Glycyrrhizae are prepared as a raw material.
In order to further enhance the effect of improving immunity, enriching yin and nourishing kidney, relax bowel and defecation and delaying senescence, the present invention is excellent
Choosing is prepared in the raw material of the composition, and one of Chinese yam, fructus lycii and Poria cocos or a variety of are still further comprised.
Chinese yam of the present invention is the dry rhizome of Dioscoreaceae plant Chinese yam.Chinese yam is sweet in flavor, mild-natured, returns spleen, lung, kidney channel,
It is adjustable immunity, anti-oxidant, anti-aging, antitumor, there is obvious hypoglycemic effect.For the West with above-mentioned special ratios
Ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and Radix Glycyrrhizae synergistic effect, the present invention preferably prepare the raw material of the composition
In, the dosage of Chinese yam is 2~10 parts, more preferably 2~8 parts.
Fructus lycii of the present invention is the dry mature fruit of Lycium barbarum L. of solanaceae.Fructus lycii is sweet in flavor, mild-natured, returns liver, kidney
Had the function of strengthen immunity, anti-oxidant, reducing blood lipid, hypoglycemic, protection liver and anti-aging.In order to above-mentioned spy
American Ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and the Radix Glycyrrhizae of certainty ratio act synergistically, and the present invention preferably prepares described group
In the raw material for closing object, the dosage of fructus lycii is 2~10 parts, more preferably 3~9 parts.
Poria cocos of the present invention is the dry sclerotia of polyporaceae fungus, sweet in flavor, light, mild-natured, return heart, lung, spleen, kidney
Through, have the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart, have strengthen immunity, antitumor, anti-aging, reducing blood lipid, liver protection, diuresis,
The effects of anti-inflammatory, sleeping.For American Ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and the Radix Glycyrrhizae with above-mentioned special ratios
Synergistic effect, the present invention are preferably prepared in the raw material of the composition, and the dosage of Poria cocos is 1~10 part, more preferably 2~8 parts.
As a preferred solution of the present invention, the composition uses the raw material including following ingredient to be prepared:
As a preferred solution of the present invention, the composition uses the raw material including following ingredient to be prepared:
As a preferred solution of the present invention, the composition uses the raw material including following ingredient to be prepared:
In above-mentioned preferred embodiment, the weight ratio of American Ginseng, Radix Astragali and coconut albumen is in (1~6): (2~12): (0.5~7),
More preferably (2~6): (7~12): in the range of (1~5).
As further preferred embodiment of the invention, the composition of the enriching yin and nourishing kidney is with the West of above-mentioned dosage part
The raw material that ginseng, dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis, Radix Glycyrrhizae, Chinese yam, fructus lycii and Poria cocos form is prepared.
Composition provided by the invention can be mixed according to the method for this field routine.In order to further increase above-mentioned group
The yin enriching and kidney nourishing effect of object is closed, and convenient for being mixed with product, the preferably described composition of the present invention as effective component and auxiliary material
It is prepared with the following method: taking each raw material, be cooked by slow fire after sufficiently being impregnated after mixing with water, then ultrasonic extraction, in separation
Clear liquid, concentration, it is dry to get.
Raw material is first cooked by slow fire, ultrasonic extraction, resulting extract can incite somebody to action again by the present invention by largely practice discovery
The effective component of enriching yin and nourishing kidney is enriched with to greatest extent, so that it is guaranteed that can play synergistic effect between effective component.
The present invention protects application of the composition in the food or health care product of preparation enriching yin and nourishing kidney simultaneously.
Specifically, the food or health care product of enriching yin and nourishing kidney provided by the invention, be using the composition as effective component,
The customary adjuvant of food or health care product is added, is prepared according to conventional methods in the art.
The present invention protects application of the composition in the drug of preparation prevention or treatment constipation simultaneously.
As a kind of concrete application mode, for preventing or treating the drug of constipation using the composition as effective component,
The customary adjuvant of drug is added, is prepared according to conventional methods in the art.The drug is preferably peroral dosage form, such as common
Tablet, capsule, oral solution etc..It is taken for the ease of patient, and plays ease constipation in a manner of optimal pharmacokinetics
The effect of defaecation, the preferably described drug of the present invention are tablet.
Specifically, the present invention provides a kind of tablet of enriching yin and nourishing kidney, on the basis of composition provided by the invention, also wrap
Include adhesive, disintegrating agent, lubricant, corrigent and filler.
Wherein:
The adhesive can be selected from one of starch slurry, gelatin solution, sodium cellulose glycolate, hydroxypropyl cellulose
Or it is several.In the raw material of the tablet, the dosage of described adhesive is preferably 0.01~8 part, and more preferably 0.1~0.5 part.
It is fine that the disintegrating agent can be selected from dried starch, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose sodium, crosslinking methylol
Tie up one or more of plain sodium.In the raw material of the tablet, the dosage of the disintegrating agent is preferably 0.01~3 part, more excellent
It is selected as 0.5~1 part.
The lubricant can be selected from magnesium stearate, talcum powder, superfine silica gel powder, hydrogenated vegetable oil, one or more of.?
In the raw material of the tablet, the dosage of the lubricant is preferably 0.01~1.5 part, and more preferably 0.01~0.09 part.
The corrigent can be selected from one in saccharin sodium, Sucralose, honey element, stevioside, Aspartame or stevioside
Kind is several.In the raw material of the tablet, the dosage of the corrigent is preferably 0.01~1.5 part, more preferably 0.1~
0.5 part.
The filler can be selected from one or more of starch, dextrin, mannitol, antierythrite, microcrystalline cellulose.?
In the raw material of the tablet, the dosage of the filler is preferably 0.5~10 part, and more preferably 0.5~5 part.
As a kind of specific embodiment of the invention, the drug using the composition as effective component, further include as
The auxiliary material of lower parts by weight:
As a kind of specific embodiment of the invention, the drug using the composition as effective component, further include as
The auxiliary material of lower parts by weight:
Present invention simultaneously provides the preparation method of said medicine, specifically comprise the following steps: by the composition first with fill out
It fills agent, disintegrating agent and corrigent to be uniformly mixed, adds adhesive and be uniformly mixed, it is mixed to add lubricant for whole grain after drying
It closes uniformly, tablet is made in tabletting.
The raw material sources safety that scheme provided by the invention uses, preparation method is simple, utilizes different medicinal of each ingredient
Mechanism gives full play to the synergistic function between each ingredient, can be achieved at the same time and supports kidney to women enriching yin, improves immunity, profit
The effect of intestines defaecation and anti-aging.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
Present embodiments provide a kind of composition of enriching yin and nourishing kidney, raw material composition are as follows: American Ginseng 1g, dendrobium candidum 12g,
Radix Astragali 11g, coconut albumen 1g, radix polygonati officinalis 2g, Radix Glycyrrhizae 5g.
The composition is prepared with the following method: take each raw material, be soaked in water half an hour after mixing, after be cooked by slow fire
Boil 60 minutes, then ultrasonic extraction 30 minutes, separate supernatant, concentration, spray drying to get.
Embodiment 2
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 1, difference is only that its raw material forms
Are as follows: American Ginseng 3g, dendrobium candidum 6g, Radix Astragali 2g, coconut albumen 7g, radix polygonati officinalis 12g, Radix Glycyrrhizae 2g.
Embodiment 3
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 1, difference is only that its raw material forms
Are as follows: American Ginseng 6g, dendrobium candidum 2g, Radix Astragali 7.5g, coconut albumen 0.5g, radix polygonati officinalis 6g, Radix Glycyrrhizae 10g.
Embodiment 4
Present embodiments provide a kind of composition of enriching yin and nourishing kidney, raw material composition are as follows: American Ginseng 5g, dendrobium candidum 3g,
Radix Astragali 9g, coconut albumen 2g, radix polygonati officinalis 9g, Radix Glycyrrhizae 7g, Chinese yam 2g, fructus lycii 5g, Poria cocos 8g.
The composition is prepared with the following method: take each raw material, be soaked in water half an hour after mixing, after be cooked by slow fire
Boil 60 minutes, then ultrasonic extraction 30 minutes, separate supernatant, concentration, spray drying to get.
Embodiment 5
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 4, difference is only that its raw material forms
Are as follows: American Ginseng 6g, dendrobium candidum 6g, Radix Astragali 10g, coconut albumen 1g, radix polygonati officinalis 6g, Radix Glycyrrhizae 3g, Chinese yam 6g, fructus lycii 6g, Poria cocos 6g.
Embodiment 6
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 4, difference is only that its raw material forms
Are as follows: American Ginseng 2g, dendrobium candidum 10g, Radix Astragali 8g, coconut albumen 3g, radix polygonati officinalis 5g, Radix Glycyrrhizae 6g, Chinese yam 8g, fructus lycii 4g, Poria cocos 4g.
Embodiment 7
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 4, difference is only that its raw material forms
Are as follows: American Ginseng 3g, dendrobium candidum 8g, Radix Astragali 7g, coconut albumen 5g, radix polygonati officinalis 7g, Radix Glycyrrhizae 4g, Chinese yam 5g, fructus lycii 9g, Poria cocos 2g.
Embodiment 8
A kind of composition of enriching yin and nourishing kidney is present embodiments provided, compared with Example 4, difference is only that its raw material forms
Are as follows: American Ginseng 4g, dendrobium candidum 4g, Radix Astragali 12g, coconut albumen 4g, radix polygonati officinalis 8g, Radix Glycyrrhizae 8g, Chinese yam 4g, fructus lycii 3g, Poria cocos 3g.
Embodiment 9
Present embodiments provide a kind of tablet of enriching yin and nourishing kidney, raw material composition are as follows: the composition that embodiment 1 provides, with
And sodium cellulose glycolate 0.25g, dried starch 0.75g, magnesium stearate 0.05g, saccharin sodium 0.25g, microcrystalline cellulose 0.5g.
The preparation method of the tablet specifically: mix the composition and dried starch, saccharin sodium and microcrystalline cellulose
It closing uniformly, adds sodium cellulose glycolate, be uniformly mixed, after wet grain is dry, whole grain adds magnesium stearate, it is uniformly mixed,
Tablet is made in tabletting.
Embodiment 10
A kind of tablet of enriching yin and nourishing kidney is present embodiments provided, compared with Example 9, difference is only that: being mentioned with embodiment 2
The composition that the composition of confession replaces the embodiment 1 to provide.
Embodiment 11
A kind of tablet of enriching yin and nourishing kidney is present embodiments provided, compared with Example 9, difference is only that: being mentioned with embodiment 3
The composition that the composition of confession replaces the embodiment 1 to provide.
Embodiment 12
Present embodiments provide a kind of tablet of enriching yin and nourishing kidney, raw material composition are as follows: the composition that embodiment 4 provides, with
And sodium cellulose glycolate 0.25g, dried starch 0.75g, magnesium stearate 0.05g, saccharin sodium 0.25g, microcrystalline cellulose 0.5g.
The preparation method of the tablet specifically: mix the composition and dried starch, saccharin sodium and microcrystalline cellulose
It closing uniformly, adds sodium cellulose glycolate, be uniformly mixed, after wet grain is dry, whole grain adds magnesium stearate, it is uniformly mixed,
Tablet is made in tabletting.
Embodiment 13
The tablet for present embodiments providing a kind of enriching yin and nourishing kidney, compared with embodiment 12, difference is only that: using embodiment 5
The composition that the composition of offer replaces the embodiment 4 to provide.
Embodiment 14
The tablet for present embodiments providing a kind of enriching yin and nourishing kidney, compared with embodiment 12, difference is only that: using embodiment 6
The composition that the composition of offer replaces the embodiment 4 to provide.
Embodiment 15
The tablet for present embodiments providing a kind of enriching yin and nourishing kidney, compared with embodiment 12, difference is only that: using embodiment 7
The composition that the composition of offer replaces the embodiment 4 to provide.
Embodiment 16
The tablet for present embodiments providing a kind of enriching yin and nourishing kidney, compared with embodiment 12, difference is only that: using embodiment 8
The composition that the composition of offer replaces the embodiment 4 to provide.
Comparative example 1
This comparative example provides a kind of tablet of enriching yin and nourishing kidney, and compared with Example 9, difference is only that, as effectively at
Coconut albumen is not used in the composition divided.
Comparative example 2
This comparative example provides a kind of tablet of enriching yin and nourishing kidney, and compared with Example 9, difference is only that, as effectively at
In the composition divided, the coconut albumen is replaced with semen coicis.
Comparative example 3
This comparative example provides a kind of tablet of enriching yin and nourishing kidney, and compared with embodiment 12, difference is only that, as effectively at
Coconut albumen is not used in the composition divided.
Comparative example 4
This comparative example provides a kind of tablet of enriching yin and nourishing kidney, and compared with embodiment 12, difference is only that, as effectively at
In the composition divided, the coconut albumen is replaced with semen coicis.
Experimental example 1
This experimental example has detected the yin enriching and kidney nourishing effect of the tablet of the offer of embodiment 13.
This experimental example chooses SD female rats 60,200 ± 20g of weight, is randomly divided into 6 groups, every group 10: normal control
Group, model control group, positive controls, low dose group, middle dose group, high dose group.
Wherein:
Except Normal group mouse carries out sham-operation, other group of mouse carries out oophorectomy；
Normal group, model control group stomach-filling 1mL/100g physiological saline；
Positive controls stomach-filling concentration is the stilbestrol liquor of 0.01mg/mL, 1mL/100g；
Low dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.0046g/ml, according to
1ml/100g carries out stomach-filling；
Middle dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.0092g/ml, according to
1ml/100g carries out stomach-filling；
High dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.023g/ml, according to
1ml/100g carries out stomach-filling；
The daily stomach-filling of every group of rat is primary.Continuous gavage 42d.
Last stomach-filling simultaneously after fasting 12h, measures E with conventional radioimmunoassay2, (concrete operation method is detailed in LH, FSH content
Measure the kit specification of each substance).It the results are shown in Table 1.
Table 1: rat blood serum E2, LH, FSH measurement result (N=10)
| Group | E2(pg/ml) | LH(pg/ml) | FSH(pg/ml) |
| Blank control group | 25.67±3.39** | 3.14±0.09** | 2.16±0.37** |
| Model control group | 16.12±2.48 | 5.89±0.23 | 4.03±0.51 |
| Positive controls | 23.36±4.75** | 3.28±0.17** | 2.29±0.56** |
| Low dose group | 17.85±2.74** | 4.79±0.18 | 3.62±0.21** |
| Middle dose group | 18.89±3.82** | 4.13±0.14* | 3.18±0.33** |
| High dose group | 21.23±3.61** | 3.42±0.29* | 2.51±0.34** |
Note: compared with model group: * P < 0.01, * * P < 0.05
After animal is put to death, adrenal gland is taken out in dissection, weighs Organ weight, calculates organ coefficient.Organ coefficient=internal organs matter
Amount (mg)/weight (g) the results are shown in Table 2.
Table 2: adult rat adrenal tissue organ coefficient measurement result ()
| Group | n | Adrenal gland coefficient |
| Blank control group | 10 | 0.173±2.134★★ |
| Model control group | 10 | 0.132±3.976 |
| Positive controls | 10 | 0.169±1.317 |
| Low dose group | 10 | 0.152±1.172★★ |
| Middle dose group | 10 | 0.157±2.289★ |
| High dose group | 10 | 0.171±1.135★ |
Note: compared with model group:★P < 0.01,★★P < 0.05
E can be improved in compared with the control group, the present composition2Level improves adrenal gland coefficient, reduces LH, FSH water
It is flat, adjusting organism endocrine is played, improves adrenal cortex morphological function, to have the function that enriching yin and nourishing kidney.
Experimental example 2
This experimental example has detected the strengthen immunity effect of the tablet of the offer of embodiment 13.
Kunming mouse 120 are chosen, weight 18-22g is randomly divided into 3 big groups, is divided into 4 groups, every group 10 per big group
Only: Normal group, low dose group, middle dose group, high dose group.
Low dose group: the tablet that embodiment 13 provides is dissolved in water, is configured to the solution of concentration 0.23g/ml；
Middle dose group: the tablet that embodiment 13 provides is dissolved in water, is configured to the solution of concentration 0.46g/ml；
High dose group: the tablet that embodiment 13 provides is dissolved in water, is configured to the solution of concentration 1.15g/ml；Be configured to by
By 0.2ml/10 (kg.bw) volume to intragastric administration on mice after test solution, control group stomach-filling gives isometric distilled water, once a day, even
Following index is measured after continuous administration 30d.
ConA inducing mouse Splenic vein hemodynamics experimental result is shown in Table 3.
Table 3:ConA inducing mouse Splenic vein hemodynamics experimental result
Note: it is compared with blank group*P < 0.05
The tardy kenel reaction result of mouse is shown in Table 4.
Table 4: the tardy kenel reaction result of mouse
| Group | Animal (only) | Swelling degree of the paw (mm) |
| Blank control group | 10 | 0.26±0.17 |
| Low dose group | 10 | 0.39±0.19 |
| Middle dose group | 10 | 0.43±0.09 |
| High dose group | 10 | 0.51±0.23△ |
Note: it is compared with blank group△P < 0.05
The measurement result of NK cell activity is shown in Table 5.
Table 5:NK cell activity measurement ()
Note: it is compared with blank group★P < 0.05
It can be seen that from table 3, table 4, table 5 and compared with blank group, normal mouse lymph can be improved in 3 groups of basic, normal, high dosage
Ability of cell proliferation, swelling degree of the paw and NK cell activity.High dose group is remarkably improved normal mouse lymphopoiesis energy
Power, swelling degree of the paw and NK cell activity.Show that product provided by the invention has and improve immunity of organisms, enhances body disease-resistant
The effect of ability.
Experimental example 3
This experimental example has detected the anti-aging effect of the tablet of the offer of embodiment 13.
Kunming kind female mice 50, weight 18-22g are chosen, is randomly divided into 5 groups, every group 10: is Normal group, low
Dosage group, middle dose group, high dose group.
Low dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.023g/ml, according to
1ml/100g carries out stomach-filling；
Middle dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.046g/ml, according to
1ml/100g carries out stomach-filling；
High dose group: being dissolved in water for the tablet that embodiment 13 provides, be configured to the solution of concentration 0.138g/ml, according to
1ml/100g carries out stomach-filling.0.5mL5%D- galactose solution is injected under the daily nape of remaining each group in addition to blank control group, it is right
Give isometric physiological saline water according to group, once a day, after continuously giving mouse tested material 30 days, measures serum, liver, brain group
Malonaldehyde (MDA) content and SOD activity are knitted, the results are shown in Table 6 and table 7.
Table 6: the influence to mouse MDA content
Note: it is compared with model group#P < 0.01.##P < 0.05
Table 7: on the active influence of SOD in Mice
Note: it is compared with model group▽P < 0.01.▽▽P < 0.05
Compared with the control group, product provided by the invention can reduce serum, liver, MDA content in brain tissue, can be with
Serum, liver, SOD activity in brain tissue are improved, has the function that anti-aging.
Experimental example 4
This experimental example has investigated embodiment 9~11 and the tablet of the offer of comparative example 1~2 imitates the treatment of constipation patient
Fruit.
The instructions of taking of the tablet are as follows: daily 1 time, each taking dosage be 0.046g/kg weight.
Choose every group of 30 people of patient for being diagnosed as constipation.Meet following standard for examination person, 1. the constipation course of disease is greater than 6 months,
There is paresthesia epilepsy within nearest 3 months；2. the age is greater than 16 years old, less than 80 years old person；3. patient signs informed consent form, voluntary participation sheet
Research.
Constipation clinical score: 1. autonomous defecation: there is (0 point), by drug, hand assisted or bowel lavage defecation (3 points)；2. awareness of defecation
Sense: having (0 point), without (1 point)；3. voluntarily stool interval: defecation was primary (0 point) on 1st~2, and defecation was primary (1 point) on 3rd~4,5~
Defecation on the 6th is primary (2 points), and defecation is primary (3 points) within 6 days or more, cannot voluntarily defecation (4 points)；4. defecation effort: arranging naturally
Just, no defecation is laborious (0 point), must exert oneself defecation (1 point), effort can defecation (2 points)；5. each defecation time: 1~10min
(0 point), 11~20min (1 point), 21~30min (2 points), 30min or more (3 points)；6. just matter: lump is dispersed in (3 points), lump
At item (2 points), there is crackle (1 point) in item, it is soft (0 point) at item light；7. abdominal distension, abdominal pain, defecation are felt not to the utmost, rectal tenesmus sense, anus
Door sense of obstruction, exhaust 6 symptoms of unsmooth sense are with without (0 point), slight (1 point), and obviously (2 points), unbearably 4 grades of (3 points) score.
Efficacy assessment standard " new Chinese medicine guideline of clinical investigations ", and clinic is combined, intend following primary symptom curative effect certainly and comments
Price card is quasi-: 1. clinical recovery: primary symptom disappears, and defecation is normal, and constipation clinical symptoms integral is 0；2. effective: clinical symptoms obviously change
Kind, clinical symptoms integral reduces >=2/3 before relatively treating；3. effectively: clinical symptoms improve, but clinical symptoms integral reduction by 1/2~
2/3；4. improving: clinical symptoms improve, but reduce≤1/2 before the relatively treatment of clinical symptoms integral；5. invalid: clinical symptoms without
Improve or aggravate, clinical symptoms integral is increased without reduction or instead.The results are shown in Table 8.
Table 8: therapeutic effect of the tablet to constipation patient
Note: total effective rate=(clinical recovery+effective+effectively+improve)/every group of total number of cases × 100%
Experimental example 5
This experimental example has investigated embodiment 12~16 and the tablet of the offer of comparative example 3~4 imitates the treatment of constipation patient
Fruit.
The instructions of taking of the tablet are as follows: daily 1 time, each taking dosage be 0.046g/kg weight.
Choose every group of 40 people of patient for being diagnosed as constipation.Meet following standard for examination person, 1. the constipation course of disease is greater than 6 months,
There is paresthesia epilepsy within nearest 3 months；2. the age is greater than 16 years old, less than 80 years old person；3. patient signs informed consent form, voluntary participation sheet
Research.
Constipation clinical score: 1. autonomous defecation: there is (0 point), by drug, hand assisted or bowel lavage defecation (3 points)；2. awareness of defecation
Sense: having (0 point), without (1 point)；3. voluntarily stool interval: defecation was primary (0 point) on 1st~2, and defecation was primary (1 point) on 3rd~4,5~
Defecation on the 6th is primary (2 points), and defecation is primary (3 points) within 6 days or more, cannot voluntarily defecation (4 points)；4. defecation effort: arranging naturally
Just, no defecation is laborious (0 point), must exert oneself defecation (1 point), exerts that earn can defecation (2 points)；5. each defecation time: 1~10min
(0 point), 11~20min (1 point), 21~30min (2 points), 30min or more (3 points)；6. just matter: lump is dispersed in (3 points), lump
At item (2 points), there is crackle (1 point) in item, it is soft (0 point) at item light；7. abdominal distension, abdominal pain, defecation are felt not to the utmost, rectal tenesmus sense, anus
Door sense of obstruction, exhaust 6 symptoms of unsmooth sense are with without (0 point), slight (1 point), and obviously (2 points), unbearably 4 grades of (3 points) score.
Efficacy assessment standard " new Chinese medicine guideline of clinical investigations ", and clinic is combined, intend following primary symptom curative effect certainly and comments
Price card is quasi-: 1. clinical recovery: primary symptom disappears, and defecation is normal, and constipation clinical symptoms integral is 0；2. effective: clinical symptoms obviously change
Kind, clinical symptoms integral reduces >=2/3 before relatively treating；3. effectively: clinical symptoms improve, but clinical symptoms integral reduction by 1/2~
2/3；4. improving: clinical symptoms improve, but reduce≤1/2 before the relatively treatment of clinical symptoms integral；5. invalid: clinical symptoms without
Improve or aggravate, clinical symptoms integral is increased without reduction or instead.The results are shown in Table 9.
Table 9: therapeutic effect of the tablet to constipation patient
Note: total effective rate=(clinical recovery+effective+effectively+improve)/every group of total number of cases × 100%
It can be seen from the above result that the tablet that various embodiments of the present invention provide all has good therapeutic effect to constipation patient.
Although above having used general explanation, specific embodiment and test, the present invention is made to retouch in detail
It states, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Range.
Claims (10)
1. a kind of composition of enriching yin and nourishing kidney, which is characterized in that be prepared using the raw material for including following component: American Ginseng,
Dendrobium candidum, Radix Astragali, coconut albumen, radix polygonati officinalis and Radix Glycyrrhizae；
Wherein the weight ratio of American Ginseng, Radix Astragali and coconut albumen is preferably (1~6): (2~12): (0.5~7), more preferably (2
~6): (7~12): (1~5).
2. composition according to claim 1, which is characterized in that in parts by weight, using the raw material including following ingredient
It is prepared:
Preferably, it is prepared using the raw material for including following ingredient:
It is highly preferred that being prepared using the raw material for including following ingredient:
3. composition according to claim 1 or 2, which is characterized in that the raw material further includes 2~10 parts of Chinese yam part, excellent
It is selected as 2~8 parts；
And/or the raw material further includes 2~10 parts of fructus lycii, preferably 3~9 parts；
And/or the raw material further includes 1~10 part of Poria cocos, preferably 2~8 parts.
4. composition according to claim 1, which is characterized in that be prepared using the raw material for including following ingredient:
5. composition according to claim 4, which is characterized in that be prepared using the raw material for including following ingredient:
Preferably, it is prepared using the raw material for including following ingredient:
It is highly preferred that being prepared using the raw material for including following ingredient:
6. composition described in Claims 1 to 5 any one, which is characterized in that using the method preparation included the following steps
It forms: taking each raw material, be cooked by slow fire after sufficiently being impregnated after mixing with water, then ultrasonic extraction, separate supernatant, be concentrated, it is dry, i.e.,
?.
7. composition described in Claims 1 to 5 any one is in the food of preparation enriching yin and nourishing kidney, the health care of preparation enriching yin and nourishing kidney
Application in the drug of product and/or preparation for preventing or treating constipation.
8. a kind of for preventing or treating the drug of constipation, which is characterized in that be combined described in Claims 1 to 5 any one
Object is as effective component；
Preferably, the drug further includes following auxiliary material: adhesive, disintegrating agent, lubricant, corrigent and filler；
More preferably:
Described adhesive is selected from one or more of starch slurry, gelatin solution, sodium cellulose glycolate, hydroxypropyl cellulose；
The disintegrating agent is selected from dried starch, Sodium Hydroxymethyl Stalcs, low-substituted hydroxypropyl cellulose sodium, croscarmellose sodium
One or more of；
The lubricant is selected from one or more of magnesium stearate, talcum powder, superfine silica gel powder, hydrogenated vegetable oil；
The corrigent is selected from one of saccharin sodium, Sucralose, honey element, stevioside, Aspartame or stevioside or several
Kind；
The filler is selected from one or more of starch, dextrin, mannitol, antierythrite, microcrystalline cellulose.
9. drug according to claim 8, which is characterized in that with composition described in Claims 1 to 5 any one be have
Ingredient is imitated, further includes the auxiliary material of following parts by weight:
Preferably, further include the auxiliary material of following parts by weight:
It is highly preferred that further including the auxiliary material of following parts by weight:
10. the method for preparing the drug of claim 8 or 9, which comprises the steps of: the composition is first
It is uniformly mixed with filler, disintegrating agent and corrigent, adds adhesive and be uniformly mixed, whole grain after drying adds lubrication
Agent is uniformly mixed, tabletting.
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| CN201810931263.2A CN108936665A (en) | 2018-08-15 | 2018-08-15 | A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof |
| TW108102285A TWI721367B (en) | 2018-08-15 | 2019-01-21 | Composition for regulating endocrine, improving immunity, delaying aging and preventing or treating constipation, its application and preparation method thereof |
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| CN201810931263.2A CN108936665A (en) | 2018-08-15 | 2018-08-15 | A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof |
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| CN110279809A (en) * | 2019-07-11 | 2019-09-27 | 北京中京丰创科技有限公司 | A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof |
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| CN101253988A (en) * | 2008-04-07 | 2008-09-03 | 北京惠中铭捷生物科技有限公司 | Health food with moistening sausage defaecate function and its preparation |
| CN102389554A (en) * | 2011-11-18 | 2012-03-28 | 广州白云山和记黄埔中药有限公司 | Chinese medicinal formula capable of invigorating kidney yang and tonifying kidney yin as well as its product |
| CN103372103A (en) * | 2012-04-20 | 2013-10-30 | 孙明宗 | Traditional Chinese medicine health-care tea and preparation method thereof |
| KR20170062846A (en) * | 2015-11-30 | 2017-06-08 | 농업회사법인 바닮 주식회사 | Medicinal herb beverages including Saururus chinensis and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998735A (en) * | 2016-07-20 | 2016-10-12 | 李撰 | Medical wine with functions of reducing blood glucose, blood pressures and blood lipid and method for preparing medical wine |
| CN106177495A (en) * | 2016-08-11 | 2016-12-07 | 吴邵军 | Chinese medicine composition for the treatment of diabetes and preparation method thereof |
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2018
- 2018-08-15 CN CN201810931263.2A patent/CN108936665A/en active Pending
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101253988A (en) * | 2008-04-07 | 2008-09-03 | 北京惠中铭捷生物科技有限公司 | Health food with moistening sausage defaecate function and its preparation |
| CN102389554A (en) * | 2011-11-18 | 2012-03-28 | 广州白云山和记黄埔中药有限公司 | Chinese medicinal formula capable of invigorating kidney yang and tonifying kidney yin as well as its product |
| CN103372103A (en) * | 2012-04-20 | 2013-10-30 | 孙明宗 | Traditional Chinese medicine health-care tea and preparation method thereof |
| KR20170062846A (en) * | 2015-11-30 | 2017-06-08 | 농업회사법인 바닮 주식회사 | Medicinal herb beverages including Saururus chinensis and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110279809A (en) * | 2019-07-11 | 2019-09-27 | 北京中京丰创科技有限公司 | A kind of composition of enriching yin and nourishing kidney and the preparation method and application thereof |
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| TWI721367B (en) | 2021-03-11 |
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