CN101474347A - Oral solid preparation for promoting sleep and preparation method thereof - Google Patents
Oral solid preparation for promoting sleep and preparation method thereof Download PDFInfo
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- CN101474347A CN101474347A CNA2007100605381A CN200710060538A CN101474347A CN 101474347 A CN101474347 A CN 101474347A CN A2007100605381 A CNA2007100605381 A CN A2007100605381A CN 200710060538 A CN200710060538 A CN 200710060538A CN 101474347 A CN101474347 A CN 101474347A
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- hypnotic
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Abstract
The invention relates to an oral solid preparation for improving sleep and a preparation method thereof. The components and parts by weight are as follows: 50-150 parts of wild jujube, 10-50 parts of rhizoma anemarrhenae, 10-50 parts of tuckahoe and 10-50 parts of rhizoma ligustici wallichii. The preparation method has the following steps: (1) weighing the medicines according to the parts by weight thereof; (2) carrying out extraction of the medicines by adding solvent, concentrating the extracting solution; (3) drying the concentrated solution, thus obtaining the dry powder, namely the finished product of the oral solid preparation. Adopting the traditional Chinese herbal medicines, the oral solid preparation takes adjustment of physiological functions of human body as major means to achieve the objective of treating sleeplessness. The oral solid preparation has the advantage of being free from problems such as drug dependence and the like.
Description
Technical field
The invention belongs to medicine or field of health care food, particularly relate to oral solid formulation of a kind of hypnotic and preparation method thereof.
Background technology
Along with rhythm of life is accelerated day by day, long-time psychentonia, pressure is overweight causes increasing healthy population to begin insomnia, and typical insomnia performance is to toss about several hrs in bed can not fall asleep, even fall asleep, can wake up again soon.Compare with the normal person, the insomniac shows obviously that intelligence descends, vulnerable, old and feeble symptom such as too fast, and often insomnia can be brought out gastric ulcer even cancer.The medicine of Cure for insomnia disease mainly contains at present, and oral class sleeping pill, intramuscular injection and intravenously administrable, these preparations all can cause toxicity in various degree and rely on addiction, cause gastrointestinal, heart discomfort and hepatorenal damage easily.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, oral solid formulation of a kind of hypnotic and preparation method thereof is provided, this method is crossed the contained active ingredient of the other side's Chinese crude drug and pharmacological action is analyzed, and the extraction that determine to be fit to, drying process also prepare taking convenience, solid preparation that dose is little by the appropriate formulations means.
The objective of the invention is to adopt following scheme to realize:
A kind of oral solid formulation of hypnotic, its constituent and parts by weight thereof are respectively:
Semen Ziziphi Spinosae 50-150 part, Rhizoma Anemarrhenae 10-50 part, Poria 10-50 part, Rhizoma Chuanxiong 10-50 part.
And the optimum parts by weight of its constituent are respectively:
100 parts of Semen Ziziphi Spinosaes, 30 parts of the Rhizoma Anemarrhenaes, 30 parts in Poria, 20 parts of Rhizoma Chuanxiongs.
A kind of preparation method of oral solid formulation of hypnotic, preparation method may further comprise the steps:
(1). by weight each component medical material is weighed;
(2). each component medical material solubilizer extracts, and extracting solution concentrates;
(3). the concentrated solution drying gets dry powder and is the oral solid formulation finished product.
And described extraction solvent comprises water or ethanol, and they are with the blended mixed solvent of arbitrary proportion.
And times weight range of described extraction solvent is 3-20 times.
And described extracting solution concentrates mode and comprises that concentrating under reduced pressure and normal pressure concentrate etc.
And described concentrated solution proportion is 1.00-1.30.
And, described concentrated solution drying comprise drying under reduced pressure, constant pressure and dry, spray drying, cryodesiccated one of them.
Advantage of the present invention and good effect are:
The present invention utilizes Chinese traditional Chinese herbal medicine, is main means with the physiological function of adjusting human body, reaches the purpose of Cure for insomnia, and its advantage is not have problem such as drug dependence.Nourish blood tonifying liver, mind tranquilizing and the heart calming of Semen Ziziphi Spinosae among the we; The Poria mind tranquilizing and the heart calming; Rhizoma Anemarrhenae nourishing YIN and clearing away heat; The Rhizoma Chuanxiong regulating QI is soothing the liver, is used for neurasthenia, hyposomnia, amnesia, palpitation with fear etc.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described; Following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1:
Semen Ziziphi Spinosae 1500g, Rhizoma Anemarrhenae 300g, Poria 300g, Rhizoma Chuanxiong 200g, it is standby to weigh
Above raw material decocts with water 2 times, adds 8 times of amounts of water at every turn, filters, and merging filtrate is evaporated to proportion 1.10, lyophilization, and dried cream powder is broken, crosses 80 mesh sieves, gets dry powder 440g, is the oral solid formulation finished product.
Embodiment 2:
Semen Ziziphi Spinosae 500g, Rhizoma Anemarrhenae 100g, Poria 500g, Rhizoma Chuanxiong 300g, it is standby to weigh
Above raw material decocts with water 2 times, adds 6 times of amounts of water at every turn, filters, and merging filtrate, normal pressure are concentrated into proportion 1.15, normal temperature drying, and dried cream powder is broken, crosses 80 mesh sieves, gets dry powder 250g, is the oral solid formulation finished product.
Embodiment 3:
Semen Ziziphi Spinosae 800g, Rhizoma Anemarrhenae 500g, Poria 100g, Rhizoma Chuanxiong 230g, it is standby to weigh
Above raw material decocts with water 2 times, adds 5 times of amounts of water at every turn, filters, and merging filtrate is evaporated to proportion 1.35, and spray drying gets dry powder 280g, is the oral solid formulation finished product.
Embodiment 4:
Semen Ziziphi Spinosae 1000g, Rhizoma Anemarrhenae 500g, Poria 200g, Rhizoma Chuanxiong 300g, it is standby to weigh
Above raw material adds 50% ethanol extraction 2 times, and each 4 times of amounts of solubilizer are filtered, and merging filtrate is evaporated to proportion 1.20, and drying under reduced pressure gets dry powder 200g, is the oral solid formulation finished product.
Above-mentioned oral solid formulation finished product can add relevant auxiliary materials and prepare corresponding dosage forms according to the conventional production method of medicine or field of food.
Claims (8)
1. the oral solid formulation of a hypnotic, it is characterized in that: its constituent and parts by weight thereof are respectively:
Semen Ziziphi Spinosae 50-150 part, Rhizoma Anemarrhenae 10-50 part, Poria 10-50 part, Rhizoma Chuanxiong 10-50 part.
2. the oral solid formulation of a kind of hypnotic according to claim 1, it is characterized in that: the optimum parts by weight of its constituent are respectively:
100 parts of Semen Ziziphi Spinosaes, 30 parts of the Rhizoma Anemarrhenaes, 30 parts in Poria, 20 parts of Rhizoma Chuanxiongs.
3. the preparation method of the oral solid formulation of an a kind of hypnotic as claimed in claim 1, it is characterized in that: preparation method may further comprise the steps:
(1). by weight each component medical material is weighed;
(2). each component medical material solubilizer extracts, and extracting solution concentrates;
(3). the concentrated solution drying gets dry powder and is the oral solid formulation finished product.
4. the preparation method of the oral solid formulation of a kind of hypnotic according to claim 3, it is characterized in that: described extraction solvent comprises water or ethanol, and they are with the blended mixed solvent of arbitrary proportion.
5. according to the preparation method of the oral solid formulation of the described a kind of hypnotic of claim 4, it is characterized in that: times weight range of described extraction solvent be 3-20 doubly.
6. the preparation method of the oral solid formulation of a kind of hypnotic according to claim 3 is characterized in that: described extracting solution concentrates mode and comprises that concentrating under reduced pressure and normal pressure concentrate.
7. the preparation method of the oral solid formulation of a kind of hypnotic according to claim 3, it is characterized in that: described concentrated solution proportion is 1.00-1.30.
8. the preparation method of the oral solid formulation of a kind of hypnotic according to claim 3 is characterized in that: described concentrated solution drying comprise drying under reduced pressure, constant pressure and dry, spray drying, cryodesiccated one of them.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100605381A CN101474347A (en) | 2007-12-31 | 2007-12-31 | Oral solid preparation for promoting sleep and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100605381A CN101474347A (en) | 2007-12-31 | 2007-12-31 | Oral solid preparation for promoting sleep and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101474347A true CN101474347A (en) | 2009-07-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100605381A Pending CN101474347A (en) | 2007-12-31 | 2007-12-31 | Oral solid preparation for promoting sleep and preparation method thereof |
Country Status (1)
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| CN (1) | CN101474347A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488826A (en) * | 2011-12-14 | 2012-06-13 | 哈药集团中药二厂 | Method for preparing freeze-dried oral preparation of spina date seed decoction |
| CN102716313A (en) * | 2012-07-05 | 2012-10-10 | 河北工程大学 | Anti-dairy cow transport stress pharmaceutical composition |
| CN102764340A (en) * | 2012-08-14 | 2012-11-07 | 中国热带农业科学院热带生物技术研究所 | Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof |
| CN104189411A (en) * | 2014-08-22 | 2014-12-10 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine preparation for improving sleeping quality |
| CN104623352A (en) * | 2013-11-08 | 2015-05-20 | 成都百草和济科技有限公司 | Medicine composition for improving sleep |
| CN113952408A (en) * | 2021-11-25 | 2022-01-21 | 江西汇仁药业股份有限公司 | Pharmaceutical composition for improving sleep quality |
-
2007
- 2007-12-31 CN CNA2007100605381A patent/CN101474347A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488826A (en) * | 2011-12-14 | 2012-06-13 | 哈药集团中药二厂 | Method for preparing freeze-dried oral preparation of spina date seed decoction |
| CN102488826B (en) * | 2011-12-14 | 2013-07-03 | 哈药集团中药二厂 | Method for preparing freeze-dried oral preparation of spina date seed decoction |
| CN102716313A (en) * | 2012-07-05 | 2012-10-10 | 河北工程大学 | Anti-dairy cow transport stress pharmaceutical composition |
| CN102764340A (en) * | 2012-08-14 | 2012-11-07 | 中国热带农业科学院热带生物技术研究所 | Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof |
| CN102764340B (en) * | 2012-08-14 | 2014-05-28 | 中国热带农业科学院热带生物技术研究所 | Traditional Chinese medicine composite capable of improving sleep and preparation method and application thereof |
| CN104623352A (en) * | 2013-11-08 | 2015-05-20 | 成都百草和济科技有限公司 | Medicine composition for improving sleep |
| CN104623352B (en) * | 2013-11-08 | 2018-01-05 | 成都百草和济科技有限公司 | A kind of pharmaceutical composition for improving sleep |
| CN104189411A (en) * | 2014-08-22 | 2014-12-10 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine preparation for improving sleeping quality |
| CN113952408A (en) * | 2021-11-25 | 2022-01-21 | 江西汇仁药业股份有限公司 | Pharmaceutical composition for improving sleep quality |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090708 |