CN101757268A - Traditional Chinese medicine composite for treating Insomnia and lethargy and preparation method thereof - Google Patents
Traditional Chinese medicine composite for treating Insomnia and lethargy and preparation method thereof Download PDFInfo
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- CN101757268A CN101757268A CN200810236371A CN200810236371A CN101757268A CN 101757268 A CN101757268 A CN 101757268A CN 200810236371 A CN200810236371 A CN 200810236371A CN 200810236371 A CN200810236371 A CN 200810236371A CN 101757268 A CN101757268 A CN 101757268A
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Abstract
The invention discloses a traditional Chinese medicine composite for treating Insomnia and lethargy and a preparation method thereof. The traditional Chinese medicine composite is prepared from raw materials of shizandra berry, salvia miltiorrhiza, nangzhou chrysanthemum, medlar, spina date seed, baked licorice and the like. In the formula, the shizandra berry has the functions of astringing yin, promoting the production of body fluid, absorbing essences, fixing element, calming heart and relieving restlessness; the salvia miltiorrhiza has the efficacies of cooling blood, clearing heart and nourishing the blood and tranquilization; the nangzhou chrysanthemum has the functions of clearing liver, improving vision and refreshing and is matched with the medlar to achieve the efficacies of enhancing liver, building body, improving visition and helping recovering fatigue; the spina date seed has the obvious functions of calming, hypnosis, soothing the nerve and nourishing heart; and the licorice acts a role of mediating the medicines. The composite can be used for preparing medicaments and health care products for treating Insomnia and lethargy, has the characteristics of no toxic and side-effect, convenient taking, high cure rate, remarkable effect, economical and practical property and the like, and is worth of clinical generalization and use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its production and use and the application aspect Cure for insomnia disease, lethargy.
Background technology
Along with the raising of people's living standard, also increasing from the life stress of each side, suffer from the insomnia, lethargy patient sharply increases.
The insomnia mainly shows as the lighter's difficulty falling asleep, easily wakes up in the sleep, and is difficult to once more sleeping; Wake up early morning too early.Weight person lies awake all night, and often with headache and dizzy, spiritlessness and weakness, palpitation and amnesia, irritability, dreaminess etc., the patient often experiences anxiety to insomnia and be frightened.
Insomnia's harm: 1. body immunity descends, and the resistance of various diseases is weakened.2. cause hypomnesis, headache.3. influence work, studying and living.4. can cause autonomic nervous dysfunction.5. often insomnia can cause senile dementia.6. often insomnia makes the people cross presenility, shortens the life-span.
The lethargy is a kind of over-drastic sleep on daytime or narcolepsy.Main feature is: (1) EDS or narcolepsy, narcolepsy can not explain that prolong the transit time that reaches complete wakefulness when clear-headed with the deficiency length of one's sleep; (2) every day occurs this sleep disorder, continue more than 1 month or narcolepsy repeatedly, cause tangible worries or influence work or family life.(3) get rid of the drowsiness and narcolepsy on daytime that various organic diseases cause.
Lethargy's harm: it can make your health suffer damage for a long time and final collapse.Your limbs coordination ability is descended, influence work, even have an accident; But also influence people's personality, make your become anxiety and irritability; Worse, the somebody also can become estranged with the external world gradually because of drowsiness, causes the consequence of self-isolation.
At present, Cure for insomnia disease and lethargy's medicine has Chinese medicine, Western medicine is also arranged, the patient when selecting generally based on Western medicine, because of its instant effect, taking convenience, but Cure for insomnia disease and lethargy's Western medicine generally all belongs to the psychiatric department medicine, because the particularity of psychiatric department medicine takes this type of medicine for a long time and easily produce drug resistance, and toxic and side effects is big, the multiple organ of human body is all had infringement, is the root of multiple disease.
Summary of the invention
The inventor is engaged in Cure for insomnia disease and lethargy's research for many years, on the experiential basis of summing up accumulation for many years, in conjunction with theory of Chinese medical science, the books of a large amount of Chinese medicines have been read about Cure for insomnia disease, lethargy, carried out a large amount of trial tests, finally be developed into a kind of not only can Cure for insomnia disease, and the lethargy is had equally the Chinese medicine composition of unique curative effect.This pharmaceutical composition have have no side effect, taking convenience, characteristics such as economical and practical, be worth clinical expansion.
One of purpose of the present invention has been to disclose Cure for insomnia disease, lethargy's Chinese medicine composition;
Two of purpose of the present invention has been to disclose the preparation method of Cure for insomnia disease, lethargy Chinese medicine composition;
Three of purpose of the present invention has been to disclose the application of Chinese medicine composition aspect Cure for insomnia disease, lethargy.
The detailed technical scheme of the present invention is as follows: the Chinese medicine composition that the invention discloses a kind of Cure for insomnia disease, lethargy, it is characterized in that, it comprises that described raw medicinal material comprises as the raw medicinal material of the following parts by weight of active ingredient or its activity extract and pharmaceutically useful carrier:
5～30 parts of Fructus Schisandrae Chinensis, 5～30 parts of Radix Salviae Miltiorrhizaes, 5～30 parts of Flos Chrysanthemi, 5～30 parts of Fructus Lycii, 5～30 parts of Semen Ziziphi Spinosaes, 5～30 parts of Radix Glycyrrhizae Preparatas.
The preferred raw medicinal material ratio of weight and number of the present invention is:
12 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
In a preferred embodiment of the present invention,, make activity extract with the conventional solvent extraction of described raw medicinal material.Preferred conventional solvent is selected from water, ethanol or their mixture.
Chinese medicine composition of the present invention can be any dosage form of intestinal canal administration and parenterai administration, preferably raw medicinal material or its activity extract and any or several pharmaceutically acceptable carrier fully is mixed and made into oral formulations.Preferred oral formulations is decoction, tablet, granule, drop pill, pill or capsule.
The invention also discloses the preparation method of Cure for insomnia disease, lethargy's Chinese medicine composition, comprising:
A. the raw medicinal material with recipe quantity drops in the extraction pot, adds to be selected from water, and ethanol or its mixture reflux as solvent, collect filtrate, and 2-3 time so repeatedly, the filtration back concentrates and obtains activity extract; With activity extract with make tablet or capsule after pharmaceutically acceptable carrier fully mixes; Perhaps
B. Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Fructus Lycii, Semen Ziziphi Spinosae, the Radix Glycyrrhizae Preparata pulverize separately with recipe quantity becomes the fine powder mixing, sieves, and adds Mel, uses water pill, makes pill.
C makes tea bag with Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Fructus Lycii, Semen Ziziphi Spinosae, Radix Glycyrrhizae Preparata, as tea-drinking.
When with the mixture of second alcohol and water when extracting solvent, concentration of ethanol is 55～95% (V/V).
In a preferred embodiment of the present invention, the activity extract that obtains among the said method a further being extracted respectively through ethyl acetate and n-butyl alcohol make refining extract, is that 1: 1.0～2.0 ratio fully is mixed and made into drop pill according to refining extract and Polyethylene Glycol ratio of weight and number then.
The side separates as follows:
Fructus Schisandrae Chinensis: temperature; Sour, sweet.Return lung, the heart, kidney channel.It is astringent or styptic treatment for spontaneous sweating to have convergence, supplementing QI for promoting the production of body fluid, kidney calming, the nourishing kidney of astringing the lung, effect such as calm the nerves, can improve corticocerebral regulating power, increase the motility of excited and process of inhibition, promote concentrating of central nervous system's process of inhibition, make excitement and suppress two kinds of nervous process balanced more.Promptly all effective in cure to drowsiness, forgetful insomnia.
Radix Salviae Miltiorrhizae: hardship is slightly cold.GUIXIN, Liver Channel.Has promoting blood circulation to restore menstrual flow, effects such as the relieving restlessness that clears away heart-fire, calming heart and tranquilizing mind.Be used for dysphoria and insomnia, Chang Peiwu Semen Ziziphi Spinosae treatment severe palpitation, insomnia.
Flos Chrysanthemi: sweet, cold.Return lung, Liver Channel.Have nourishing the liver to improve visual acuity, clear away heart-fire, the kidney invigorating, invigorating the spleen and regulating the stomach, effect wets one's whistle, promotes the production of body fluid.Control headache, dizzy etc.
Fructus Lycii: sweet, flat.Go into liver, kidney channel.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, the treating the liver kidney yin is lost, soreness of the waist and knees, dizziness, dizzy etc.
Semen Ziziphi Spinosae: sweet, flat.Go into the heart, spleen, liver, gallbladder meridian.Nourishing the liver, mind calming is calmed the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.
Radix Glycyrrhizae: sweet, flat.Go into spleen, stomach, lung meridian.With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.
Chinese medicine composition of the present invention removes and to have Cure for insomnia disease, lethargy, also to sight amblyopia, visual deterioration, lethargy are depressed etc. better curative effect is arranged.
Chinese medicine composition of the present invention can be mixed and made into oral formulations with above-mentioned each medical material and any or several pharmaceutically acceptable pharmaceutical carrier.For example decoction, tablet, granule, drop pill, pill or capsule or the like.For example above-mentioned all flavor medical materials are mixed grinding to the powder altogether, be respectively charged into capsule, each 10 grams, day 2-4 time.Special situation can suitable being regulated according to patient's the state of an illness.For example above-mentioned all medicines are made tea bag, patient every day is for tea-drinking.
One or more pharmaceutically acceptable pharmaceutical carriers of the present invention comprise: conventional diluent, filler (as lactose, aspartame, xylitol, Polyethylene Glycol), binding agent (starch, microcrystalline Cellulose), disintegrating agent (as carboxymethyl cellulose, the low hydroxypropyl cellulose that replaces), lubricant (as Pulvis Talci, magnesium stearate), wetting agent (as propylene glycol, ethanol), stabilizing agent (EDTA-2Na, sodium thiosulfate, sodium pyrosulfite, sodium sulfite, ethanolamine, sodium bicarbonate, nicotiamide).Can also comprise: magnesium phosphate, magnesium stearate, smoothers sugar, lactose, pectin, propylene glycol, dried starch, Tween-80, dextrin, starch, gelatin, cellulose substances or the like.For example methylcellulose, microcrystalline Cellulose, low melt point paraffin, Polyethylene Glycol, mannitol, cocoa butter or an amount of magnesium stearate or the like.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention.But do not limit the present invention in any way, the umber in the embodiment of the invention can be chosen as gram or kilogram according to the actual needs.
Embodiment 1
12 parts of [prescription] Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
[method for making] drops into the medical material of above-mentioned recipe quantity in the extraction pot, decocts with water 2 hours, collects filtrate, and 2 times repeatedly, after the filtration, mix all filtrate, discard residue, concentrate the decoction of making 2000ml, divide and take for 2-3 time/day.After taking for three weeks, the patient sleeps and recovers normal.
Embodiment 2
12 parts of [prescription] Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
[method for making] with 85% (V/V) ethanol extraction 2 times, uses 1500ml with above-mentioned medical material at every turn, extracts 1～2 hour.Obtain extract and add starch 55g, mixing, drying then.Other adds starch 85g, xylitol 125g, and aspartame 0.6g, mix homogeneously is ground into fine powder, with 60% ethanol system granule, drying; It is an amount of to add magnesium stearate, and mix homogeneously is pressed into 1000, every heavy 1g.After taking for six weeks, the patient sleeps and recovers normal.
Embodiment 3
12 parts of [prescription] Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
[method for making] above 6 flavor Chinese crude drugs are ground into fine powder, and mixing sieves, and drying is encapsulated, promptly.
Embodiment 4
12 parts of [prescription] Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
[method for making] medicinal material extract: according to above-mentioned recipe quantity with the ethanol of 70% weight and aqueous mixtures reflux, extract, 2 times, each mixture with 2100ml second alcohol and water extracted 1 hour, filtrate is condensed into extractum, add 250ml water, make extractum become suspension, reuse ethyl acetate and n-butyl alcohol extract respectively 2 times, and each 250ml, extract are concentrated into the dried refining extract that becomes after filtering and merging.Get substrate 24.9g polyethylene glycol 6000,54.2g Macrogol 4000,6.9g glycerol and put in the container, in water-bath, be heated to 80 ℃, treat whole fusions after, add refining extract 21.5g, be stirred to dissolving, evenly.The medicinal liquid for preparing is transferred in the reservoir, and airtight and insulation is at 80 ℃, and regulator solution titer valve splashes in 25 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe methyl-silicone oil, and drying, promptly.After taking for 4 weeks, sx.
Embodiment 5
12 parts of [prescription] Fructus Schisandrae Chinensis, 10 parts of Radix Salviae Miltiorrhizaes, 8 parts of Flos Chrysanthemi, 10 parts of Fructus Lycii, 10 parts of Semen Ziziphi Spinosaes, 7 parts of Radix Glycyrrhizae Preparatas.
[method for making] pulverizes each component, and the mix homogeneously that sieves adds 3.5% Mel then and makes pill.
Embodiment 6
[prescription] Fructus Schisandrae Chinensis 12g, Radix Salviae Miltiorrhizae 10g, Flos Chrysanthemi 8g, Fructus Lycii 10g, Semen Ziziphi Spinosae 10g, Radix Glycyrrhizae Preparata 7g.
[method for making] makes refining extract according to above-mentioned method according to embodiment 3, with other medical material mix homogeneously, adds amylum pregelatinisatum 3g, magnesium stearate 2.5g then, mix homogeneously, 40% ethanol pelletize, tabletting bag film-coat.After taking for 5 weeks, sx.
Claims (10)
1. a Chinese medicine composition contains Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Fructus Lycii, Semen Ziziphi Spinosae, Radix Glycyrrhizae Preparata.
2. the described Chinese medicine composition of claim 1 can be used for preparing Cure for insomnia disease, lethargy's medicine, health product.
3. the described Chinese medicine composition of claim 1, wherein the raw medicinal material parts by weight are:
5～30 parts of Fructus Schisandrae Chinensis, 5～30 parts of Radix Salviae Miltiorrhizaes, 5～30 parts of Flos Chrysanthemi, 5～30 parts of Fructus Lycii, 5～30 parts of Semen Ziziphi Spinosaes, 5～30 parts of Radix Glycyrrhizae Preparatas.
4. the described Chinese medicine composition of claim 1, wherein the raw medicinal material ratio of weight and number is:
Fructus Schisandrae Chinensis 12g, Radix Salviae Miltiorrhizae 10g, Flos Chrysanthemi 8g, Fructus Lycii 10g, Semen Ziziphi Spinosae 10g, Radix Glycyrrhizae Preparata 7g.
5. the described Chinese medicine composition of claim 1, described activity extract wherein is a water, ethanol or their chemical compound are as solvent extraction.
6. each described Chinese medicine composition of claim 1～5 is characterized in that above-mentioned raw materials medical material or its activity extract and any or several pharmaceutically acceptable carrier are mixed and made into oral formulations.
7. the described Chinese medicine composition of claim 6, oral formulations wherein is decoction, tablet, granule, drop pill, pill or capsule.
8. prepare the method for each described Chinese medicine composition of claim 1～7, it comprises:
A. the raw medicinal material with recipe quantity drops in the extraction pot, adds entry, and ethanol or its mixture reflux as solvent, collect filtrate, 2-3 time so repeatedly, concentrates after filtering and obtains activity extract; With activity extract with make tablet or capsule after pharmaceutically acceptable carrier fully mixes; Perhaps
B. Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Fructus Lycii, Semen Ziziphi Spinosae, the Radix Glycyrrhizae Preparata pulverize separately with recipe quantity becomes the fine powder mixing, sieves, and adds 3-5% Mel, uses water pill, makes pill.
C. Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Fructus Lycii, Semen Ziziphi Spinosae, Radix Glycyrrhizae Preparata peace equal portions are mixed and made into tea bag.
9. the method for claim 8 comprises also that wherein the activity extract that will obtain among the method a further extracts respectively through ethyl acetate and n-butyl alcohol, makes refining extract; Be that 1: 1.0～2.0 ratio is fully mixed them according to refining extract and Polyethylene Glycol ratio of weight and number then, make drop pill.
10. each described Chinese medicine composition of claim 1～7 is in preparation Cure for insomnia disease, lethargy's medicine, the application in the health product.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198178A (en) * | 2011-05-24 | 2011-09-28 | 北京京蒙五鑫科技开发有限公司 | Zhenrong Yinao capsules |
| CN103566045A (en) * | 2013-11-14 | 2014-02-12 | 黑龙江八一农垦大学 | Pharmaceutical composition for improving sleep and preparation method thereof |
| CN104983902A (en) * | 2015-06-23 | 2015-10-21 | 中国人民解放军第三军医大学 | Traditional Chinese medicine composition for treating insomnia and dreaminess and preparation method and application thereof |
| CN106466368A (en) * | 2016-10-10 | 2017-03-01 | 河南中渤医疗科技有限公司 | A kind of Chinese medicine improving the health care of sleep |
| CN106924527A (en) * | 2017-03-07 | 2017-07-07 | 广州馥邦科技应用有限公司 | It is a kind of for medicine that is antifatigue, improving the health care of sleep food and preparation method thereof |
| CN107223920A (en) * | 2017-07-03 | 2017-10-03 | 山东中科婀娇时代生物科技有限公司 | The processing method of jujube jujube core and the jujube core prepared using this method, jujube core tea |
| CN107582851A (en) * | 2017-11-08 | 2018-01-16 | 马雪英 | It is a kind of to treat drowsiness medicine and preparation method thereof |
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2008
- 2008-11-08 CN CN200810236371A patent/CN101757268A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198178A (en) * | 2011-05-24 | 2011-09-28 | 北京京蒙五鑫科技开发有限公司 | Zhenrong Yinao capsules |
| CN102198178B (en) * | 2011-05-24 | 2013-01-30 | 北京京蒙五鑫科技开发有限公司 | Traditional Chinese medicine capsule for treating insomnia, amnesia, insufficient blood supply, and the like |
| CN103566045A (en) * | 2013-11-14 | 2014-02-12 | 黑龙江八一农垦大学 | Pharmaceutical composition for improving sleep and preparation method thereof |
| CN103566045B (en) * | 2013-11-14 | 2015-09-16 | 黑龙江八一农垦大学 | The preparation method of the pharmaceutical composition of improving water flood |
| CN104983902A (en) * | 2015-06-23 | 2015-10-21 | 中国人民解放军第三军医大学 | Traditional Chinese medicine composition for treating insomnia and dreaminess and preparation method and application thereof |
| CN106466368A (en) * | 2016-10-10 | 2017-03-01 | 河南中渤医疗科技有限公司 | A kind of Chinese medicine improving the health care of sleep |
| CN106924527A (en) * | 2017-03-07 | 2017-07-07 | 广州馥邦科技应用有限公司 | It is a kind of for medicine that is antifatigue, improving the health care of sleep food and preparation method thereof |
| CN107223920A (en) * | 2017-07-03 | 2017-10-03 | 山东中科婀娇时代生物科技有限公司 | The processing method of jujube jujube core and the jujube core prepared using this method, jujube core tea |
| CN107582851A (en) * | 2017-11-08 | 2018-01-16 | 马雪英 | It is a kind of to treat drowsiness medicine and preparation method thereof |
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Application publication date: 20100630 |