CN106924527A - It is a kind of for medicine that is antifatigue, improving the health care of sleep food and preparation method thereof - Google Patents
It is a kind of for medicine that is antifatigue, improving the health care of sleep food and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The purpose of the present invention is that the monarch based on traditional Chinese medicine is theoretical, and it is raw material to use medicine-food two-purpose natural plants, there is provided it is a kind of it is safe, have no side effect, can be eaten for medicine that is antifatigue, improving the health care of sleep with long-term taking and preparation method thereof.It is of the invention for medicine that is antifatigue, improving the health care of sleep food by monarch drug in a prescription, ministerial drug, adjutant, constitute medicine, the monarch drug in a prescription is prepared from by lily, spina date seed, the seed of Oriental arborvitae, and wherein lily, spina date seed, the weight ratio of the seed of Oriental arborvitae are 0.8~1.2:0.8~1.2:0.8~1.2;The ministerial drug is prepared from by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, and wherein ginseng, the tuber of dwarf lilyturf, the weight ratio of the fruit of Chinese magnoliavine are 0.8~1.2:0.8~1.2:0.8~1.2;The adjutant is prepared from by matrimony vine, chrysanthemum, and wherein matrimony vine, the weight ratio of chrysanthemum are 0.8~1.2:0.8~1.2;It is described medicine is prepared from by dark plum, the monarch drug in a prescription, ministerial drug, adjutant, make medicine part by weight be 4:3:2:1.
Description
Technical field
The invention belongs to medical and health technical field, and in particular to it is a kind of for medicine that is antifatigue, improving the health care of sleep food and
Its preparation method.
Background technology
People extremely pay close attention to the relation between the state of mind of body and health in recent years, particularly battle-weary to health
Influence, its reason is not only due to people and more and more recognizes the battle-weary generation that can induce various diseases, and
Also the clinical symptoms of many diseases can be deteriorated.Up to now research has shown that battle-weary is because body is receiving a variety of outer
The fuselage state during physiological reaction such as nervous and uneasy produced by boundary's environmental stimulus or stress.Certainly, it is battle-weary to remove
Beyond the reaction former to particular stimulation, also there is some common reaction paths physiologically, such as sympathetic nerve-adrenal gland medullary substance system
And pendant-adrenal cortex system is excited induces that adrenaline secretion, blood pressure rise, pulse increases and that respiratory capacity is accelerated etc. is many
Physiological reaction.Additionally, battle-weary can also be obviously promoted adrenal cortex release cortin and secondary various clinical symptom.
In fact, these physiological reactions are also the adaptability defence performance or battle-weary reaction of a kind of body.Accordingly, it can be said that
Battle-weary is that body regards bed in the stress for bearing internal and external environment induction by central nervous system, influence and via brain
The secondary all flexible defense reactions in bottom.It is generally believed that battle-weary reaction needs to be carried out by two kinds of physiological pathways
Regulation, one kind is to discharge norepinephrine or stimulate adrenal gland medullary substance secretion adrenaline to play between sympathetic nervous system tip to make
With another kind is stimulated by the releasing hormone that hypothalamus discharges corticotropin by neuroendocrine pathway
Pendant secretes corticotropin and acts on adrenal cortex and promotes glucocorticoid secretion to complete.
At present, for clinical symptoms such as sleep-disorder that is battle-weary or causing and fatigues, general widely used sleep medicine,
Or the antianxiety drug thing such as benzodiazepine classes is used to alleviate and treat, but these medicines again because have certain side effect with
Drug dependence and limit it and use scope.Although it is anti-oxidant that people also often can nourish tonic or vitamin E etc. using some
Agent is used to improve fatigue state, although these methods are really helped for alleviation or on organism fatigue is recovered with certain, simultaneously
It is not most appropriate solution, therefore clinically reaches improvement with greater need for nervous battle-weary to improve by alleviating
Sleep quality and action effect that is anti-uneasy and promoting fatigue recovery.
The content of the invention
The purpose of the present invention is the theoretical monarch based on traditional Chinese medicine, and it is raw material to use medicine-food two-purpose natural plants, is carried
For it is a kind of it is safe, have no side effect, can be eaten for medicine that is antifatigue, improving the health care of sleep with long-term taking and preparation method thereof.
It is of the invention for medicine that is antifatigue, improving the health care of sleep food by monarch drug in a prescription, ministerial drug, adjutant, constitute medicine, the monarch drug in a prescription by
Lily, spina date seed, the seed of Oriental arborvitae are prepared from, and wherein lily, spina date seed, the weight ratio of the seed of Oriental arborvitae are 0.8~1.2:0.8~1.2:
0.8~1.2;The ministerial drug is prepared from by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, and wherein ginseng, the tuber of dwarf lilyturf, the weight ratio of the fruit of Chinese magnoliavine are 0.8
~1.2:0.8~1.2:0.8~1.2;The adjutant is prepared from by matrimony vine, chrysanthemum, and wherein matrimony vine, the weight ratio of chrysanthemum are
0.8~1.2:0.8~1.2;Described medicine is prepared from by dark plum, the monarch drug in a prescription, ministerial drug, adjutant, the part by weight that makes medicine are
4:3:2:1.
Monarch drug in a prescription in the present invention is made up of lily, spina date seed, the taste medicinal material of the seed of Oriental arborvitae three, wherein lily sweet and slightly bitter taste, it is mild-natured,
Enter cardiopulmonary warp, be clinically usually used in moistening the lung and relieve the cough, yin-nourishing disappears heat, and we are application target using its clearing away the heart fire and tranquillizing drug effect;
Additionally, lily is rich in the nutrient such as starch, protein, fat and calcium, phosphorus, iron vitamin B1, B2, C and carrotene, it may have
Good nutritious tonifying effect.Spina date seed it is sour it is sweet, mild-natured, enter the heart, spleen, liver, gallbladder channel, with mental-tranquilization, arrest sweating promotes the production of body fluid
Effect, is adapted to the insomniac of heart deficiency of liver-blood, because spina date seed is rich in significant quantities of fat oil and protein, and containing sterol, triterpenes,
Jujuboside, volume vitamin C isoreactivity composition, it may have certain calmness, hypnosis and anti-uneasy effect.The medicine of the seed of Oriental arborvitae
Property it is sweet, flat, enter the heart, the spleen channel, with certain bushing god and antiperspirant efficacy of allaying excitement, clinically with the effect of calming the nerves that property is gentle
Really, have certain benefit property concurrently again while calmness, be usually used in the deficienty of the heart blood and induced insomnia, palpitation with fear person, also frequently as tonics informal dress.
Ministerial drug in the present invention is made up of ginseng, the tuber of dwarf lilyturf, the taste medicinal material of the fruit of Chinese magnoliavine three, clinically by the combination of this three tastes medicinal material
Also known as meaning Shengmai San, purged heat for nourishing generate fluid, enriching yin, the effect with relieving restlessness that clears away heart-fire.Up to now research has shown that to give birth to arteries and veins
The peace gas that can also refresh oneself is dissipated, also can be used to improve fatigue.Ministerial drug from Shengmai San be intended to it is auxiliary benefit monarch drug in a prescription improve the health care of sleep and improves resist it is tired
Labor effect.
Adjutant in the present invention is made up of matrimony vine, the taste medicinal material of chrysanthemum two, wherein, the sweet flat matter of the fruit of Chinese wolfberry moistens, enters lung, liver, kidney
Through, clinically be used for tonifying kidney and benefiting sperm, with blood-enriching tranquillizing and the effect nourished the liver to improve visual acuity.Additionally, the fruit of Chinese wolfberry is rich in there is glycine betaine, many
The multiple nutritional components such as sugar, crude fat, crude protein, carrotene, vitamin, calcium, phosphorus, iron, zinc, manganese, linoleic acid, it may have one
Fixed antifatigue effect.Chrysanthemum, it is pungent, bitter, sweet, be slightly cold, it is apt to head clearing, clinically it is usually used in the heat of surname dissipate Liver Channel, soothing the liver is bright
Mesh.Adjutant helps the monarch and his subjects' effect from matrimony vine and the taste medicinal material of chrysanthemum two for assistant.
The medicine that makes in the present invention selects dark plum, and the medical instrument has coordinating the drug actions of a prescription to make, sour, puckery, puts down, Return liver, spleen, lung, large intestine
Through, and with astringing the lung, puckery intestines and the effects such as promote the production of body fluid, be clinically also commonly used for anti-aging and dispelling fatigue.Dark plum is medicine is reconciled
And draw footpath be intended to promote curative effect.
Meanwhile, medicine food of the invention also can effectively improve and prevent because of many clinical secondary disease of psychosoma fatigue cause
Shape, it is also possible to for maintaining, recovering and promoting muscle power and improve the health care of sleep and reach sedative action effect, and have no side effect.This hair
The bioactivity of bright medicine food is shown in many experiments such as mouse autogenic movement experiment, sleep experiments and pendency based on it
Be able to what is confirmed and prove in the drug action of meaning, medicine food bioactivity apparently higher than in its raw material it is any single into
Point.Had shown that by research, above-mentioned medicine tableware has the advantages that safe, raw material sources are stable, quality controllable, and can be effective
Alleviate, mitigate nervous centralis stress effects, reach and improve the health care of sleep, alleviate battle-weary and anti-uneasy effect, improve sleep quality
The many clinical symptoms battle-weary and secondary with alleviation.
Further, the preparation of the medicine food is granule, tablet, capsule, pill, oral liquid, effervescent tablet, medicinal extract
Agent, syrup, sustained release agent, controlled release agent or targeting preparation.
Further, medicine food also includes additive, and the additive includes excipient, lubricant, antioxidant, anti-
Rotten agent, colouring agent and sweetener;The excipient is lactose, white sugar, PEARLITOL 25C, starch or avicel cellulose;The lubrication
Agent is magnesium stearate, calcium stearate or talcum powder;The antioxidant is sulphite or ascorbic acid;The preservative is two
Hydroxyacetic acid or methaform.
Preparation method for medicine that is antifatigue, improving the health care of sleep food of the invention has following two:
The step of the first preparation method, is as follows:
A:Each raw material is weighed by weight ratio, raw material is ground into powder and is well mixed;
B:The material powder that step A is obtained adds solvent, and the solvent is water, ethanol or hydrous ethanol, described original
The weight ratio of feed powder end and solvent is 1:1~10, the solution that will be obtained utilizes the side of heating extraction, Microwave Extraction or ultrasonic extraction
Formula obtains the extract of raw material;
C:Extract is prepared into preparation.
The step of second preparation method, is as follows:
A:Each raw material is weighed by weight ratio, raw material is ground into powder and is well mixed;
B:The material powder that step A is obtained is added to the water to form a solution, after a solution is heated into the scheduled time,
Solution of filtering obtains a filter residue and first-time filtrate;Second aqueous are formed during filter residue is added into suitable quantity of water again, will
After the second aqueous heating scheduled time, filtering second aqueous obtain secondary filter residue and secondary filtrate, merge first-time filtrate and secondary
Filtrate, concentrated, dry after obtain raw material extract;
C:Extract is prepared into preparation.
The involved raw material sources stabilization of medicine of the invention food, action effect is definite, process for producing is simple, using can
OK, without drug resistance and it is safe and effective the features such as, can be effectively used for improving and prevent and treat uneasy and face for antifatigue
Bed symptom.
Brief description of the drawings:
Fig. 1 is influence of the medicine food to mouse autogenic movement.
Specific embodiment
Below by the description to embodiment, to specific embodiment of the invention such as the shape of involved each component
Mutual alignment and annexation, the effect of each several part and operation principle between shape, construction, each several part etc. are made further detailed
Explanation.
Embodiment 1:
The present embodiment propose for medicine that is antifatigue, improving the health care of sleep food by monarch drug in a prescription, ministerial drug, adjutant, constitute medicine, institute
State monarch drug in a prescription to be prepared from by lily, spina date seed, the seed of Oriental arborvitae, wherein lily, spina date seed, the weight ratio of the seed of Oriental arborvitae are 0.8~1.2:
0.8~1.2:0.8~1.2;The ministerial drug is prepared from by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, wherein the weight of ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine
Amount is than being 1:1:1;The adjutant is prepared from by matrimony vine, chrysanthemum, and wherein matrimony vine, the weight ratio of chrysanthemum are 1:1;It is described make medicine by
Dark plum is prepared from, the monarch drug in a prescription, ministerial drug, adjutant, make medicine part by weight be 4:3:2:1.
Specifically,
Above-mentioned medicine food can be prepared using any one in following two kinds of preparation methods.
The first preparation method is as follows:After by each raw material drying, raw material is weighed according to predetermined weight proportion, and through machinery
Mix after being ground into powder, addition appropriate solvent forms solution, by solution using heating extraction, Microwave Extraction or ultrasonic extraction
Mode acquisition raw material, is eventually adding additive and is made preparation.The solvent is water, ethanol or hydrous ethanol, described original
The weight ratio of feed powder end and solvent is 1:1~10.The present invention does not have specific limitation to Extracting temperature, from room temperature to solvent boiling point model
Enclose all applicable.Certain room temperature, normal pressure and extract ideal in the range of solvent boiling point, extraction time is small to 24 from 30 minutes
When in the range of can be with.
Second preparation method is as follows:After by each raw material drying, raw material is weighed according to predetermined weight proportion, and through machinery
Mix after being ground into powder, add suitable quantity of water to form a solution, after a solution is heated into the scheduled time, filter a solution
Obtain a filter residue and first-time filtrate;Second aqueous are formed during filter residue is added into suitable quantity of water again, second aqueous are heated
After the scheduled time, filtering second aqueous obtain secondary filter residue and secondary filtrate, merge first-time filtrate and secondary filtrate, carry out dense
Raw extract is obtained after contracting, drying, additive is eventually adding and is made preparation.
The additive used in preparation includes excipient, lubricant, antioxidant, preservative, colouring agent and sweetener;Institute
Excipient is stated for lactose, white sugar, PEARLITOL 25C, starch or avicel cellulose;The lubricant be magnesium stearate, calcium stearate or
Talcum powder;The antioxidant is sulphite or ascorbic acid;The preservative is dihydroxy acetic acid or methaform.
Source and the difference of collecting season due to raw material, its extract yield are likely to be slightly different, but general extraction
Thing yield can control process for producing to ensure active component more than 20% by analysis methods such as efficient liquid phases
The quality of composition.The extract addition additive of acquisition can be prepared into granule, tablet, capsule, oral liquid, effervesce
The active ingredient compositions of the different dosage forms such as piece, syrup are used for clinical improvementses and treatment uneasiness, improve sleep quality and anti-tired
Work is used.
When active ingredient compositions are extracted, or because the improvement of some needs or favourable extraction conditions can also be in a solvent
The material such as addition sodium bicarbonate (sodium bicarbonate) or SODIUM ASCORBATE (sodium ascorbate) is carried
Take.Certainly the said extracted method taken does not interfere with plant component bioactivity inherently yet.
Mouse autogenic movement experiment (ambulatory activity test) be a kind of high specificity, repeatability it is high and
With to the mankind are uneasy and tired similar Behavioral feature, thus it is widely used in anti-uneasy and antifatigue evaluating drug effect.Cause
And the drug action of the food of the medicine prepared by the present embodiment is evaluated using mouse autogenic movement experimental animal model.
The present embodiment (is purchased from Guangdong Province using the SPF grades of male 7 week old Kunming mouse of 20~22g of body weight in an experiment
Medical experiment animal center, animal licensing numbering is SCXK (Guangdong) 2013-0002), caffeine is purchased from Wako Pure
Chemical Industries, experimental animal is raised in cleaning grade laminar-flow rack, and environment temperature is 23 ± 2 DEG C, and relative humidity is
75 ± 10%, lighting hours is 12 hours/day (7:00~19:00).Experimental animal carries out drug effect after adaptability is fed one week
Active appraisal experiment.
The present embodiment determines device (Laboratory Ambulometer MODEL SMA- using experimental animal amount of exercise
10O ' HARA&Co., Ltd.) detection mouse autogenic movement amount.Be placed on mouse in experimental provision before being administered 30 minutes fit by a corpse or other object for laboratory examination and chemical testing
Experimental situation is answered, and records total autogenic movement amount of every 10 minutes.Mouse after the adaptation of 30 minutes, the sample of various concentrations
Oral administration is measured with 0.1ml/10g.Every 10 minutes after administration is record unit calculating mouse autogenic movement amount, METHOD FOR CONTINUOUS DETERMINATION 120
Minute.Control group mice oral administration is with the capacity aqueous solution.Experimental animal is grouped at random, and each experimental group uses mouse 10.
Experimental result as shown in figure 1, compared with aqueous solution control group mice, award 10mg/kg caffeines mouse from
Shipping is dynamic to be dramatically increased;And give 1g/kg (crude drug amount) medicine food mouse autogenic movement compared with the aqueous solution control group mice nothing
Significant changes;Compared with caffeine group, the autogenic movement of caffeine and medication food mouse has certain reduction to be inclined to, it was demonstrated that activity
Component composition has certain anti-uneasy effect.
Mouse pendency experiment be conventional a kind of anti-uneasy and antifatigue experiment, repeatability height and with the mankind uneasiness
With tired similar Behavioral feature, thus it is widely used in anti-uneasy and antifatigue evaluating drug effect.Thus using mouse pendency
Experimental animal model evaluates the drug action of the medicine food prepared by the present embodiment.
The present embodiment (is purchased from Guangdong Province using the SPF grades of male 7 week old Kunming mouse of 20~22g of body weight in an experiment
Medical experiment animal center, animal licensing numbering is SCXK (Guangdong) 2013-0002), caffeine is purchased from Wako Pure
Chemical Industries, experimental animal is raised in cleaning grade laminar-flow rack, and environment temperature is 23 ± 2 DEG C, and relative humidity is
75 ± 10%, lighting hours is 12 hours/day (7:00~19:00).Experimental animal carries out drug effect after adaptability is fed one week
Active appraisal experiment.
Experimental technique is to be grouped experimental animal at random, each experimental mice 10,30 points of laboratory sample oral administration
Pharmacodynamic evaluation experiment is proceeded by after clock, control group such as gives at the capacity aqueous solution.Pendency experiment is to be suspended on mouse forelimb
On diameter 2mm, 50cm long, the metal wire of parallel height 50cm, the pendency time of mouse is determined.Experimental result is as shown in table 1, with
Aqueous solution control group is compared, and the caffeine administration mouse reverse hang time shortens;With the uneasy phase for causing mouse after caffeine administration
Than medicine food has certain extension to be inclined to the pendency time.Additionally, the mouse pendency time of caffeine and medication food is given with caffeine
Medicine group is compared also has certain extension to act on.Experiment proves that the uneasy tool that medicine food causes to caffeine has some improvement.
Table 1:Influence of the active ingredient compositions to the mouse pendency time.
Compared with caffeine administration model group, * P<0.001
Medicine food induces phenobarbital the influence of mouse sleep time:
The present invention (is cured using the SPF grades of male 7 week old Kunming mouse of 20~22g of body weight purchased from Guangdong Province in an experiment
Experimental Animal Center is learned, animal licensing numbering is SCXK (Guangdong) 2013-0002), caffeine is purchased from Wako Pure
Chemical Industries, experimental animal is raised in cleaning grade laminar-flow rack, and environment temperature is 23 ± 2 DEG C, and relative humidity is
75 ± 10%, lighting hours is 12 hours/day (7:00~19:00).Experimental animal carries out drug effect after adaptability is fed one week
Active appraisal experiment.
Experimental technique is to be grouped experimental animal at random, each experimental mice 10, and each corpse or other object for laboratory examination and chemical testing is in the bar ratios of 50mg/kg penta
Oral administration before appropriate intravenous injection 30 minutes, control group such as gives at the capacity aqueous solution.The righting reflex of mouse is recorded as sleep
Time, analysis caffeine and active ingredient compositions induce phenobarbital the influence of mouse sleep time.
As shown in table 2, the aqueous solution control group mice length of one's sleep is 34.4 ± 0.4 points, 10mg/kg caffeines to experimental result
Administration mouse sleep time is 26.6 ± 0.5 points, and caffeine shortens the length of one's sleep of mouse, and mice sleep is induced to amobarbital
Time showing goes out certain wake-up facilitation.Compared with caffeine, medicine food administration shows certain extension sleep tendency, together
When medicine food also can significantly extend amobarbital induction mouse sleep time.
Table 2:Medicine food induces phenobarbital the influence of mouse sleep time.
Compared with caffeine administration model group, * P<0.001
By the confirmations of above-mentioned multiple experiments, the medicine food that the present embodiment is provided can as relax and improve the health care of sleep, body and mind it is tired
Labor and fatigue secondary uneasy disease, autonomic nerve be extremely hyperfunction and the various clinical symptoms such as hypertension are purpose pharmaceuticals, health
Food, food or food additives are used for daily life.The prevention extremely hyperfunction to uneasy, autonomic nerve of medicine food, improvement are made
Include being able in the experiment of the mice sleep, pendency time and autogenic movement frequency under central action confirming by improving with being and
Confirm.The medicine food dosage that the present invention is provided, according to conditions such as user's relative health, age, sex and body weight
Can select, typically be grown up with 60Kg as average weight, oral extract can contemplate in the range of 3g to 10g in one day, can
With part vic.Not the problems such as certain more than 10g does not exist side effect yet.
The above is only the preferred embodiments of the present invention, and any formal limitation is not done to the present invention, although this
Invention is disclosed above with preferred embodiment, but is not limited to the present invention, any those skilled in the art,
Do not depart from the range of technical solution of the present invention, when using the technology contents of the disclosure above make it is a little change or be modified to
With change Equivalent embodiments, as long as being the content without departing from technical solution of the present invention, according to technical spirit of the invention to
Any simple modification, equivalent variations and modification that upper embodiment is made, still fall within the range of technical solution of the present invention.
Claims (5)
1. it is a kind of for medicine that is antifatigue, improving the health care of sleep food, it is characterised in that by monarch drug in a prescription, ministerial drug, adjutant, to constitute medicine, it is described
Monarch drug in a prescription is prepared from by lily, spina date seed, the seed of Oriental arborvitae, and wherein lily, spina date seed, the weight ratio of the seed of Oriental arborvitae are 0.8~1.2:0.8
~1.2:0.8~1.2;The ministerial drug is prepared from by ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine, wherein the weight of ginseng, the tuber of dwarf lilyturf, the fruit of Chinese magnoliavine
Than being 0.8~1.2:0.8~1.2:0.8~1.2;The adjutant is prepared from by matrimony vine, chrysanthemum, wherein the weight of matrimony vine, chrysanthemum
Amount is than being 0.8~1.2:0.8~1.2;It is described medicine is prepared from by dark plum, the monarch drug in a prescription, ministerial drug, adjutant, make the weight of medicine
Ratio is 4:3:2:1.
2. it is according to claim 1 for medicine that is antifatigue, improving the health care of sleep food, it is characterised in that the preparation of medicine food is
Granule, tablet, capsule, pill, oral liquid, effervescent tablet, extract, syrup, sustained release agent, controlled release agent or targeting preparation.
3. it is according to claim 1 for medicine that is antifatigue, improving the health care of sleep food, it is characterised in that the medicine food also includes adding
Plus agent, the additive include excipient, lubricant, antioxidant, preservative, colouring agent and sweetener;The excipient is
Lactose, white sugar, PEARLITOL 25C, starch or avicel cellulose;The lubricant is magnesium stearate, calcium stearate or talcum powder;Institute
Antioxidant is stated for sulphite or ascorbic acid;The preservative is dihydroxy acetic acid or methaform.
4. it is according to claim 1 for medicine that is antifatigue, improving the health care of sleep food preparation method, it is characterised in that including such as
Lower step:
A:Each raw material is weighed by weight ratio, raw material is ground into powder and is well mixed;
B:The material powder that step A is obtained adds solvent, and the solvent is water, ethanol or hydrous ethanol, described raw material powder
The weight ratio of end and solvent is 1:1~10, the solution of acquisition is obtained using the mode of heating extraction, Microwave Extraction or ultrasonic extraction
Obtain the extract of raw material;
C:Extract is prepared into preparation.
5. it is according to claim 1 for medicine that is antifatigue, improving the health care of sleep food preparation method, it is characterised in that including such as
Lower step:
A:Each raw material is weighed by weight ratio, raw material is ground into powder and is well mixed;
B:The material powder that step A is obtained is added to the water to form a solution, after a solution is heated into the scheduled time, filtering
One time solution obtains a filter residue and first-time filtrate;Second aqueous are formed during filter residue is added into suitable quantity of water again, will be secondary
After the solution heating scheduled time, filtering second aqueous obtain secondary filter residue and secondary filtrate, merge first-time filtrate and secondary filtrate,
Concentrated, dry after obtain raw material extract;
C:Extract is prepared into preparation.
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Application publication date: 20170707 |