CN104971214A - Traditional Chinese medicine composition with anti-fatigue effect - Google Patents
Traditional Chinese medicine composition with anti-fatigue effect Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with an anti-fatigue effect. According to years of clinical practice, the composition aims to symptoms, such as effulgent lung fire, qi deficiency with cough and asthma, loss of blood to internal lesion caused by overexertion, forgetfulness and insomnia, febrile disease damaging fluid, acidity and pain of lumbar and knee, and blurred vision, generated by the fatigable during an illness period. The disclosed traditional Chinese medicine composition has an obvious curative effect, and can cure and effectively relieve the above symptoms. The anti-fatigue traditional Chinese medicine composition comprises the following raw materials, by weight: 3-15g of American ginseng, 6-12g of dwarf lilyturf tuber, 2-15g of Chinese magnoliavine, 6-15g of wolfberry, 9-30g of radix astragali, and 5-15g of chrysanthemum. The composition is simple in composition and reasonable in ratio, has no side effect, has a fixed curative effect, is high in reproducibility of medical treatment effect, and has extremely high security and validity.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine composition with resisting fatigue.
Background technology
Tired conventional " tiring out " represents, in general everybody had this experience.Physical activity to time certain time, histoorgan and even the temporarily-depressed phenomenon of whole body ability to work are tired.It is main mental fatigue that fatigue is divided into again somatotonia to be main physical fatigue and psychentonia.No matter physical fatigue or mental fatigue is all corticocerebral protective effect.The protectiveness that environment change facilitates brain suppresses, and fatigue represents the reduction of central nervous system's ability to work.When musculation to a certain degree time, energy substance exhaust; In blood, the factor such as metabolite accumulation, homeostasis imbalance, is all tired Producing reason.As can be seen here, fatigue is the reaction that life entity adapts to internal and external environment make, and is also a kind of physiological defense reaction.From this meaning, pay attention to there is considerable meaning to the understanding of fatigue and allaying tiredness of taking measures.Tired symptom roughly comprises following three aspects: one is feel aspect: as tired in omnidirectional, nose heave, drowsiness, unable etc.; Two is spiritual aspects: as distraction, lather, do not have patience, depressed, without earnest, often make mistakes; Three is whole body aspects: pale complexion, dizzy, muscle twitches dyspnea, dry mouth and parching tongue, hoarseness, soreness of waist and ache in legs etc.
Cause tired factor to mainly contain zinc deficiency, do not have enough sleep, lack exercise, vivotoxin accumulation, obesity, Nervous and Mental Factors, pressure greatly and endocrine disturbance, medicine factor, acidic physique etc. be all the principal element causing fatigue.A sub-health status Epidemiological study relating to 10 provinces and regions 11980 people in the whole nation shows, and the non-diseased crowd of 81.36% belongs to confirmed fatigue.Wherein, often feel tired, but the slight tired person that can recover after having a rest accounts for 68.07%; Always feel tired, and after having a rest, the moderate fatigue person of more difficult recovery accounts for 29.78%; The sever fatigue person that also cannot recover after rest accounts for 2.15%.Human body has compensatory mechanism, and tired sleeping can youngster just can adjust more once in a while, if but chronic fatigue, Abwehrkraft des Koepers will be caused to decline, also cannot recover after rest.Tired constantly accumulation, just likely develops into confirmed fatigue, impairs one's health once in a while.And the harm of fatigue mainly comprises: to the harm of human body physical agility, figure aspect, show and be difficult to be engaged in or complete some comparatively large and that action is fine and smooth, the exquisite work that consumes one's strength, cause patient to feel unable to do what one wishes deeply; To the harm of human immune system, the function of immune system of human body can be made not normal with adjustment, cause immunologic hypofunction, cause various disease; To the harm of human recycle system, nervous system, digestive system, reproductive system and sensorium.Modern Chinese medicine is thought, fatigue is a name of disease, has its etiology and pathogenesis, is commonly encountered diseases, frequently-occurring disease clinically, is that the new disease that must pay attention to is planted, is attributed to subhealth state category, relates to the vital organs of the human body, mainly based on spleen, liver, kidney.Can be recuperated under medical treatment by Chinese medical discrimination prescription, to reach the object of prevention, treatment, control.Tired is caused by the deficiency syndrome of first QI consumed wound and mental change (or not smooth) double factor.Tonify deficiency righting is not only wanted in treatment, tired calming the nerves of also should dispelling.On the one hand, tonify deficiency primordial QI reinforcing, nourish body, emptyly must to mend, canonical is prosperous, tired from removing; On the other hand, adjust smooth will, comfortable smooth meaning, refreshingly must to pacify, the heart is then peaceful, and fatigue can disappear.Fatigue is described as by Chinese medical book " slacking off ", " slack lazy ", " extremity overstrain ", " inability to raise the limbs " and " flaccidity of the limbs " etc.As " Plain Questions shows calm opinion " is said: " flaccidity of the limbs, this inability of the spleen to transport the essence of food also.", " Shengji Zonglu asthenia door " say: " impairment caused by overstrain very, the tired pole of health.", " east permanent ten book inability to bend the limbs " say: " taste void then tiredness with somnolence, inability to bend the limbs.", Qing Dynasty Lin Peiqin " the deficient section of Lei Zheng Zhi Cai " once pointed out that asthenia had five, impairment of the lung caused by overstrain damages gas, and the impairment of the spleen due to overstrain damages food, and the impairment of the heart caused by overstrain damages god, and hepatic asthenia damages blood, and impairment of the kidney caused by overstrain damages essence.Melancholia then summarises the symptom that confirmed fatigue comprehensively demonstrate,proves occurred a series of spiritual aspect, and to hypomnesis or absent minded, pharyngolaryngitis, cervical region or axillary gland are touched a tender spot, myalgia, multiple non-arthritic joint pain, headache, sleep disorder etc., its clinical manifestation has intersection to be present in the record of the disease such as " forgetful ", " pharyngalgia ", " arthralgia ", " headache ", " being insomnia ".If human body's Qi generation pathological changes, will have an impact to mind activity.As " Ling Shu Miraculous Pivot or Divine Axis is puzzled greatly " say " QI of the upper portion of the body being insufficient, the therapeutic method to keep the adverse QI flowing downwards is had a surplus, and the intestines and stomach is real and cardiopulmonary are empty, void then seek defend stay under, of a specified duration not with time on.”
The method of western medical treatment fatigue comprises medicine, immunotherapy, antiviral therapy, cognition and the behavior therapy and physical therapy, all at relief of symptoms, improves function, but still lacks that recommend, definite effective therapeutic regimen.And this disease is divided into type of deficiency of both the heart and spleen when the existing symptom of this disease of diagnosis and treatment by the traditional Chinese medical science, the deficiency of vital energy holds strongly fragrant type under the arm, the symptom such as deficiency of both the liver and kidney type and caused by hepatic stagnation qi stagnation, needs to treat to the ill respectively.And this Chinese medicine composition of the present inventor's invention is valued for the gasification function in energy integrated regulation internal organs, simultaneously positive benefiting vital QI and blood again, at health invigorating, resisting fatigue, the effect of antidotal therapy fatigue is affirmative, according to tired etiology and pathogenesis feature, select strengthening vital QI to eliminate pathogenic factors, supplementing QI and nourishing YIN, reduce phlegm clots absorbing, regulating the flow of QI to alleviate depression, heat-clearing and toxic substances removing, the square medicine of the many aspects such as harmonizing yingfen and weifen, pass through determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Yin Yang balancing, QI and blood regulating, conditioning viscera, its pathomechanism can be reversed, prevent the generation of complication, achieve good curative effect, reach from the entirety of people and recover the normal function of body.
Summary of the invention
The present inventor is engaged in Chinese medicine work for many years from generation to generation, have accumulated abundant Clinical Laboratory and case, by the analysis to this disease, research and confirmation, invent this and organize new formula, for physical fatigue crowd because tired a series of complication of producing and harm have significant curative effect, this disease can be made to obtain effective alleviation and treatment.
Therefore.In first of the present invention, provide a kind of Chinese medicine composition for the treatment of resisting fatigue, it is made up of the following raw materials according of following weight portion, unit g:
Radix Panacis Quinquefolii 3-15, Radix Ophiopogonis 6-12, Fructus Schisandrae Chinensis 2-15, Fructus Lycii 6-15, Flos Chrysanthemi 5-15, Radix Astragali 9-30.
In preferred embodiments, described Chinese medicine composition by Radix Panacis Quinquefolii 3-10, Radix Ophiopogonis 6-10, Fructus Schisandrae Chinensis 2-10, Fructus Lycii 6-10, Flos Chrysanthemi 5-10, Radix Astragali 9-25 makes.
The preparation method of this Chinese medicine composition is:
By raw material Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali is put into respectively and is decocted medicinal herbs with marmite, add proper amount of clear water to soak, the water yield was advisable there not to be medical material, after soaking 10-20 minute, first be fried boiling with intense fire, fried 10-15 minute, then with 15-20 minute at a simmer, Radix Panacis Quinquefolii, Fructus Lycii, Flos Chrysanthemi were put into frying pan fried 5-10 minute in the lump in 3-5 minute before fried end, filtering medicinal liquid, when placing warm and drinkable.Or above-mentioned raw materials is crushed to 80 ~ 120 orders respectively, and through sieving, sterilizing, dry, mixing, the production technology of extraction makes capsule, tablet or oral liquid.
Radix Panacis Quinquefolii in this Chinese medicine composition is the dry root of Araliaceae Radix Panacis Quinquefolii, has lung benefiting the moon, clear asthenic fire, effect of promoting the production of body fluid to quench thirst, archaism cloud: " Radix Panacis Quinquefolii is cool in nature and mend, all wish Radix Ginsengs and not by Radix Ginseng warm person all can with it ".Therefore mend and not dry be the special feature of Radix Panacis Quinquefolii.Radix Panacis Quinquefolii rhizome is containing glycoside, mainly ginsenoside.There are some researches show, Radix Panacis Quinquefolii has obvious effect in resisting fatigue, and Radix Panacis Quinquefolii can promote protein synthesis, regulates metabolism, rapid relieving fatigue, to regain one's strength.Radix Panacis Quinquefolii can improve anoxia enduring and the tolerance to cold of white mice, can obviously extend the mice burden swimming time, reduces serum urea nitrogen level when moving, reduces the consumption of liver glycogen, reduce the content of high dose group lactic acid after moving.Radix Panacis Quinquefolii saponin can promote that protein generates a-acetone acid through deamination reaction after being broken down into aminoacid again, and the latter participates in tricarboxylic acid cycle as intermediate product, carries out oxidative function, thus reaches the object of resisting fatigue.Fructus Schisandrae Chinensis has QI invigorating reinforcing YIN-essence, improving eyesight, strengthening bone and muscle, supports the effects such as the five internal organs.Functional component Fructus Schisandrae Polysaccharide in Fructus Schisandrae Chinensis can significantly improve mice oxygen deficit tolerance ability, and the walking weight load of energy significant prolongation mice, has and increase muscle power and antifatigue effect.Fructus Schisandrae Polysaccharide presses 100mg/kg, and 200mg/kg dosage is to mouse stomach, and mice is put into the airtight wide mouthed bottle of the 250ml that 10g Calx is housed, experiment shows, Fructus Schisandrae Polysaccharide can significantly improve the hypoxia-bearing capability of mice, points out it to have antifatigue effect.There is Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, function that lung moistening clears away heart-fire, can be used for the diseases such as calentura wound rule, restlessness and thirst, its main chemical compositions is homoisoflavone class, soaping agents, volatile oil, inorganic elements and polysaccharide etc.Radix Ophiopogonis polysaccharide is one of main active in Radix Ophiopogonis, occupy blood sugar lowering, slow down aging, resisting fatigue, the auxiliary effect such as Tumor suppression, radioprotective.The Radix Astragali has the effects such as tonifying Qi and lifting yang, stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, detoxification granulation promoting, is the traditional tonic of China.Modern pharmacological research shows, the Radix Astragali has the effects such as resisting fatigue, defying age, immunity moderation function, removing toxic substances, the Radix Astragali is containing number of chemical compositions such as saponin, pyrite, polysaccharide and aminoacid, wherein polysaccharide is Radix Astragali primary bioactive components, astragalus polysaccharides can reduce the accumulation of body blood lactic acid, enhancing body aerobic capacity, plays the effect that delay fatigue occurs, improves motor capacity.The effects such as Fructus Lycii has nourishing the liver and kidney, replenishing vital essence to improve eyesight, nourishes blood, enhancing immunity.Research display, the most practical effect of Fructus Lycii is exactly resisting fatigue and blood pressure lowering.Experiment is had to show, water extraction is adopted to extract Fructus Lycii, mice burden swimming method, pole-climbing chronometry and Mouse Liver is used heavily to claim the anti-fatigue active of method to Fructus Lycii variable concentrations extract to compare research, Fructus Lycii has the effect of significant resisting fatigue, the deposit increasing hepatic glycogen can be passed through, for body provides more energy to reach the object of resisting fatigue.
Chinese medicine composition of the present invention has the effect of resisting fatigue, can answer that QI and blood is not normal, visceral dysfunction, feelings will are not relaxed, overwork etc. and the fatigue symptom that occurs by effective prevention and therapy.This Chinese medicine composition uses the traditional Chinese medical science to pharmacology opinion, prescription by regulating negative and positive, QI and blood regulating, temperature is cool and be main by, settling five organs benefit vital essence, with reach Yin-nourishing and Yang-supporting, train consolidate, spleen kidney is taken into account, effect of invigorating the spleen and replenishing QI.
Chinese medicine composition of the present invention forms simple and practical, reasonable mixture ratio, can nourishing the blood and yin, calm the nerves, vital essence replenishing and marrow benifiting, YIN and YANG balance regulating, the spleen and stomach regulating, for occur between the fatigue phase insufficiency of the spleen, suffer from a deficiency of the kidney, the symptom such as stagnation of liver-QI with deficiency of the spleen, deficiency of the kidney yin such as excess of the liver, soreness of the waist and knees, dizziness and tinnitus, feverish sensation in the palms and soles, neurolysis, irritable, can significantly be treated and be alleviated.Chinese medicine composition of the present invention through 170 routine patient fatigue's clinical research confirmations, total effective rate 98 ﹪, cure rate 95 ﹪.No matter age size, medical history length, all can have significant curative effect within a course for the treatment of, and determined curative effect, the repeatability of medical effect is high, has no side effect, higher through clinical verification cure rate.
Detailed description of the invention
Embodiment 1
Radix Panacis Quinquefolii 3-15 gram, Radix Ophiopogonis 6-12 gram, Fructus Schisandrae Chinensis 2-15 gram, Fructus Lycii 6-12 gram, Radix Astragali 9-30 gram, Flos Chrysanthemi 5-15 restrains into.
Method for making: by raw material Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali is put into respectively and is decocted medicinal herbs with marmite, and add proper amount of clear water and soak, the water yield was advisable there not to be medical material, soak about 10-20 minute, afterwards, be first fried boiling with intense fire, fried 10-15 minute, again with 15-20 minute at a simmer, Radix Panacis Quinquefolii, Fructus Lycii, Flos Chrysanthemi were put into frying pan fried 5-10 minute in the lump, filtering medicinal liquid in 3-5 minute before fried end, when placing warm and drinkable.Or above-mentioned raw materials is carried out being crushed to 80 ~ 120 orders respectively, through sieving, sterilizing, dry, mixing, the production technologies such as extraction are made into capsule, tablet, oral liquid, extend the storage life, mouthfeel is improved, and purity is enhanced, and is applicable to suitability for industrialized production.Every day 3 times, take respectively at after half an hour after meal.
Embodiment 2
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-10 gram, Radix Ophiopogonis 6-10 gram, Fructus Schisandrae Chinensis 2-10 gram, Fructus Lycii 6-15 gram, Radix Astragali 9-20 gram, Flos Chrysanthemi 2-12 gram.
Preparation and using method: with embodiment 1.
Embodiment 3
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-12 gram, Radix Ophiopogonis 6-10 gram, Fructus Schisandrae Chinensis 2-12 gram, Fructus Lycii 6-10 gram Radix Astragali 9-25 gram, Flos Chrysanthemi 5-10 gram.
Preparation and using method: with embodiment 1.
Embodiment 4
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-10 gram, Radix Ophiopogonis 6-12 gram, Fructus Schisandrae Chinensis 2-15 gram, Fructus Lycii 6-10 gram, Radix Astragali 9-18 gram, Flos Chrysanthemi 5-15 gram.
Preparation and using method: with embodiment 1.
Embodiment 5
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-15 gram, Radix Ophiopogonis 6-12 gram, Fructus Schisandrae Chinensis 2-10 gram, Fructus Lycii 6-15 gram, Radix Astragali 9-20 gram, Flos Chrysanthemi 5-10 gram.
Preparation and using method: with embodiment 1.
Embodiment 6
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-15 gram, Radix Ophiopogonis 6-12 gram, Fructus Schisandrae Chinensis 2-15 gram, Fructus Lycii 6-12 gram, Radix Astragali 9-25 gram, Flos Chrysanthemi 5-12 gram.
Preparation and using method: with embodiment 1.
Embodiment 7
Have a Chinese medicine composition for resisting fatigue, it is made up of the raw material pressing column weight amount:
Radix Panacis Quinquefolii 3-12 gram, Radix Ophiopogonis 6-10 gram, Fructus Schisandrae Chinensis 2-12 gram, Fructus Lycii 6-15 gram, Radix Astragali 9-20 gram, Flos Chrysanthemi 5-15 gram.
Preparation and using method: with embodiment 1.
Embodiment 8: experimental example
Diagnostic criteria is with reference to the diagnostic criteria of U.S. CDC revision: the 1. major fatigue of the lasting or recurrent exerbation of unknown cause, continue more than six months, after fully having a rest, symptom is not alleviated, and decline when level of activation is more healthy 50 ﹪, 2. at least possess four in following eight: short-term attentional power or memory obviously decline simultaneously, pharyngalgia, cervical region or axillary gland swell and ache, myalgia, without red and swollen arthralgia, the headache that novel or degree increases the weight of, the sleep of not recovering from fatigue, Fatique after Sports was more than 24 hours.
Choose meet above-mentioned standard 170 example, regardless of sex, the age at 20 ~ 60 years old, the course of disease 2 months ~ 2 years.
therapeutic scheme
Treatment group: use the Chinese medicine composition in embodiment 1, take 3 every day.
criterion of therapeutical effect
Clinical symptoms weighs grading in light, and fatigue is indispensable disease, adopts Fatigue Assessment Instument to evaluate, the performance relevant in fatigue is listed one by one, point 1 ~ 7 grade of evaluation.
Efficacy evaluation is: effective: clinical symptom disappearance or obviously improve, and symptom integral reduces more than 2/3, takes a turn for the better: clinical symptom relief, and symptom integral reduces more than 1/3, invalid: clinical symptoms is without improvement or increase the weight of, and integration reduces less than 1/3.
therapeutic outcome
According to symptom scores standard, effective 160 examples of patient treatment group, effective 7 examples, total effective rate 98 ﹪, and there is not any untoward reaction.
Demonstrate Chinese medicine composition of the present invention thus and there is good effectiveness and reliability.
Claims (4)
1. have a Chinese medicine composition for resisting fatigue, it is made up of the raw material of following weight portion: Radix Panacis Quinquefolii 3-15 gram, Radix Ophiopogonis 6-12 gram, Fructus Schisandrae Chinensis 2-15 gram, Radix Astragali 9-30 gram, Fructus Lycii 6-15 gram, Flos Chrysanthemi 5-15 gram.
2. a kind of Chinese medicine composition with resisting fatigue according to claim 1, it is made up of the raw material of following weight portion: Radix Panacis Quinquefolii 3-10 gram, Radix Ophiopogonis 6-10 gram, Fructus Schisandrae Chinensis 2-10 gram, Fructus Lycii 6-10 gram, Radix Astragali 9-25 gram, Flos Chrysanthemi 5-10 gram.
3. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterized in that:
By raw material Radix Ophiopogonis, Fructus Schisandrae Chinensis, the Radix Astragali is put into respectively and is decocted medicinal herbs with marmite, add proper amount of clear water to soak, the water yield was advisable there not to be medical material, after soaking 10-20 minute, first be fried boiling with intense fire, fried 10-15 minute, then with 15-20 minute at a simmer, Radix Panacis Quinquefolii, Fructus Lycii, Flos Chrysanthemi were put into frying pan fried 5-10 minute in the lump in 3-5 minute before fried end, filtering medicinal liquid, when placing warm and drinkable.
4. the preparation method of the Chinese medicine composition described in claim 1 or 2, is characterized in that: above-mentioned raw materials is crushed to 80 ~ 120 orders respectively, and through sieving, sterilizing, dry, mixing, the production technology of extraction makes capsule, tablet or oral liquid.
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| CN114306506A (en) * | 2021-12-31 | 2022-04-12 | 南京中医药大学 | Traditional Chinese medicine compound composition with effect of enhancing organism immunity and preparation method and application thereof |
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