CN102225128B - Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases - Google Patents

Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases Download PDF

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CN102225128B
CN102225128B CN2011101716994A CN201110171699A CN102225128B CN 102225128 B CN102225128 B CN 102225128B CN 2011101716994 A CN2011101716994 A CN 2011101716994A CN 201110171699 A CN201110171699 A CN 201110171699A CN 102225128 B CN102225128 B CN 102225128B
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班登加措
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Abstract

The invention discloses a Tibetan medicine composite. In the invention, based on the experience of Tibetan medicine in prevention and treatment of heart cerebrovascular diseases and neurologic diseases, the common mineral medicines and plant medicines are selected from the traditional Tibetan medicines are reasonably matched, thereby providing a Tibetan medicine composite which comprises mineral medicines and plant medicines. Based on a basic formula comprising saxifraga stolonifera, saffron crocus, coral and mother of pearl, the medicine effects of the Tibetan medicine composite directly act on the organs of a human body; and the Tibetan medicine composite has obvious treatment effects of adjusting the blood pressure and the functions of a neurologic system and can be applied to the prevention and treatment of heart cerebrovascular diseases and neurologic diseases through the verification of clinical tests. Other Tibetan medicine components also can be added to the Tibetan medicine composite under the preferable conditions. The Tibetan medicine composite disclosed by the invention can be applied to the prevention and treatment of heart cerebrovascular diseases and neurologic diseases with the advantages of obvious medicine effects, short treatment course and no toxic or side effect; and compared with the single-component traditional medicines for reducing or enhancing the blood pressure, the medicinal composite has the effect of keeping blood pressure stable without rebound after the stop of the administration of the Tibetan medicine composite, thus the Tibetan medicine composite does not need to be taken for a long term.

Description

Tibetan medicine combination and the application in resisting cardiovascular and neurological disease drug preparation thereof
Technical field
The present invention relates to a kind of Tibetan medicine combination, particularly relate to a kind of Tibetan medicine combination that can be applied in resisting cardiovascular disease and the neurological disease drug preparation.
Background technology
Cardiovascular and cerebrovascular disease is the particularly healthy commonly encountered diseases of middle-aged and elderly people of a kind of serious threat mankind; Have " sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high, complication many "; The characteristics of " four is high by more than one ", at present, Chinese cardiovascular and cerebrovascular disease patient has surpassed 2.7 hundred million people.
Tibetanmedicine is created in area, China Qinghai-Tibet Platean; Alleviate in specific aim for a long time and accumulated a large amount of experiences aspect the heart and brain physiological load that causes to the local resident owing to unsuitable environmental conditions such as height above sea level, air drying are thin with control and the disease, wherein representational is control to altitude sickness.Altitude sickness is that the highlands is prone to send out the disease of seeing more; Be divided into acute high altitude reaction and chronic mountain reaction; The former cardinal symptom has giddy, headache, nervous, tachypnea, loss of appetite, asthenia, weak, nauseating, vomiting, abdominal distention, diarrhoea, pain uncomfortable in chest, insomnia, dim eyesight, drowsiness, dizzy, numb hand and foot, tic etc.; Sign often shows as heart rate quickening, exaggerated respiration, blood pressure mile abnormality, face or edema of the limbs, die Blausucht etc.; The latter's cardinal symptom mainly contains headache, giddy, insomnia, dreaminess, hypomnesis, transience faintness and the intestines and stomach, kidney discomfort etc.Altitude sickness in essence more belong to cardio cerebral function, nervous function impaired due to.Therefore the experience of Tibetanmedicine accumulation particularly can act on heart and brain organ, neural Tibetan medicine material and preparation thereof according to what the property of medicine sub-elected, for the modern cardiovascular and cerebrovascular disease occurred frequently of control and nervous system disease has great importance and reference function.
Summary of the invention
The object of the invention is exactly the deficiency to prior art, and a kind of Tibetan medicine combination and the application in cardiovascular and cerebrovascular vessel and neurological disease drug preparation thereof are provided.
For realizing above-mentioned purpose, technical scheme of the present invention is following:
A kind of Tibetan medicine combination is made up of mineral medicine and plant medicine, it is characterized in that containing Herba Saxifragae, Stigma Croci, Corallium Japonicum Kishinouye, Concha Margaritifera.
In the above-mentioned Tibetan medicine combination:
Herba Saxifragae is the herb of Herba Saxifragae (Saxifragga stolonifera Meerb), in Tibetan medicine and pharmacology, is used for removing heat from the liver, gallbladder-heat, lung-heat.
Stigma Croci; It is the stigma of irides Stigma Croci (Crocus sativus L.); Tradition Tibetan medicine material; Have multiple medicinal efficacy, all the time by China and foreign countries' medical circle extensive use with prevention and treatment cerebral thrombosis, disease such as vasculitis, myocardial infarction, anemia body void, menoxenia, puerperal congestion, general aching, traumatic injury, neurasthenia, palpitation with fear is demented.
Corallium Japonicum Kishinouye is recorded in " the Sanitation Ministry medicine standard (mongolian medicine fascicle), mongolian medicine title: the rising sun " main effect and is heat clearing away, detoxifcation, calmness.Be used for liver-heat, arteries and veins heat, gather disease, scorchingly hot, apoplexy, " the lung-pulse " disease.
Concha Margaritifera, be recorded in " Chinese pharmacopoeia, mainly effect is that suppressing the hyperactive liver and subsiding YANG, arresting convulsion make eye bright, it is dizzy to be used to have a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Under optimum condition, above-mentioned Tibetan medicine combination can also contain rose beryl, ruby.Wherein:
Rose beryl is recorded in " manna book on Chinese herbal medicine bright mirror " (training of loud, high-pitched sound Maqu is write, and the Tibet People's Publishing House publishes, 1994), is used for liver cirrhosis and alimentary toxicosis disease.
Ruby is recorded in " the local quality of medicinal material standard of Tibet Autonomous Region " (standard No.: XZ-BC-0019-2004; Tibetan language title: Bai Mare each), main effect be to give birth to do give birth to heat, cold relieving reinforcing the heart, dampness supplementing the brain, refreshing happy will, separate insane remove strongly fragrant, nourishing is neural, detoxifying makes eye bright.
Under optimum condition, above-mentioned Tibetan medicine combination can also further add lucky Achates, Flos Carthami, Radix Aucklandiae (Radix Vladimiriae), Fructus Hippophae extractum, Fructus Phyllanthi, Fructus Choerospondiatis, Radix Inulae, Herba Meconopsis Horridulae, natural salt, Semen Strychni, Herba Lycopodii, Fructus Rubi corchorifolii Immaturus, Achates.Wherein:
Lucky Achates is recorded in preamble said " manna book on Chinese herbal medicine bright mirror ", is used for cerebrovascular accident person.
Flos Carthami is recorded in that " Chinese pharmacopoeia is traditional medical material, and main effect be to invigorate blood circulation latus rectum, eliminating stasis to stop pain are used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury.
The Radix Aucklandiae is recorded in that " Chinese pharmacopoeia is claimed Radix Aucklandiae (Radix Vladimiriae) again, and main effect is mass dissipating and swelling eliminating, and counteracting toxic substances is treated skin ulcer, is used for sore swollen toxin, acute mastitis, scrofula, anal fistula, chronic eczema, tinea alba.
Fructus Hippophae extractum is recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0048-95, Tibetan medicine title: Da Bukanzha); Main effect is clearing and antitussive, blood circulation promoting and blood stasis dispelling, more ulcer; Be used for tracheitis, dyspepsia, diseases such as gastric ulcer and amenorrhea.
Fructus Phyllanthi, be recorded in " Chinese pharmacopoeia, main effect is clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the cough-relieving of promoting the production of body fluid is used for the heat in blood blood stasis, liver-gallbladder disease, dyspepsia, stomachache, cough, laryngalgia, xerostomia.
Fructus Choerospondiatis is recorded in " national Chinese herbal medicine compilation (upper and lower volume) " multi-section documents such as (Xie Zongwan chief editor, People's Health Publisher, 1996) and (claims GUANGSUANZAO again, the Tibetan medicine title: ma Xiao Xia).The Fructus Choerospondiatis total flavones has the raising hypoxia-bearing capability; Cardiac muscle there is protective effect, can improves arrhythmia, improve the rhythm of the heart and slow down; Main effect is promoting flow of QI and blood, tranquilizing by nourishing the heart, removing food stagnancy, detoxifcation, main qi depression to blood stasis, chest pain, shortness of breath and palpitation, neurasthenia, insomnia.
Radix Inulae, be recorded in " Chinese pharmacopoeia, main effect is invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, is used for the breast side of body, abdominal distention, vomiting dysentery, the breast side of body is dampened.
Herba Meconopsis Horridulae, (standard numbering WS3-BC-0039-95, the Tibetan medicine title: Ci Eren) main effect is synthetism, heat clearing away, pain relieving, is used for fracture, chest and back pain to be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine ".
Natural salt, be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0035-95, the Tibetan medicine title: letter wood Sa) main effect be to remove coldly be good for the stomach, wind dispelling, be used for the complication of cold Baconic or dragon, the dyspepsia that cold syndrome of the stomach causes.
Semen Strychni is recorded in that " Chinese pharmacopoeia, main effect is removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, is used for rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain, poliomyelitis sequela, rheumatoid arthritis.
Herba Lycopodii; Be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0087-95; Tibetan medicine title: add and examine), main effect is due to clearing heat and moistening lung, the blending pathology disorderly, is used for liver-heat, visceral heat, pneumonopathy, rheumatic arthritis, ageing diseases.
Fructus Rubi corchorifolii Immaturus, (the mongolian medicine title: Bo Gerilejigen) main effect is to induce sweat, transfers unit, cough-relieving, is used for underdone heat, pestilence, intermal comflict heat, flu, cough due to lung-heat, asthma, " conspicuous complying with " heat to be recorded in " the Sanitation Ministry medicine standard mongolian medicine fascicle ".
Achates, be recorded in " Tibet Autonomous Region local quality of medicinal material standard " (standard No. XZ-BC-0038-2004, the Tibetan medicine title: mana or), main effect is heat clearing away tomorrow to be used for eyes outward and to swell and ache, the order life is hidden from view.
Above-mentioned each composition weight proportioning of Tibetan medicine combination is: 3.0~8.0 parts of Herba Saxifragaes; 1.0~4.0 parts of Stigma Crocis; 1.0~4.0 parts on Corallium Japonicum Kishinouye; 3.0~8.0 parts of Concha Margaritiferas; 0.3~2.0 part of rose beryl; 0.5~2.0 part in ruby; 1.0~4.0 parts on lucky Achates; 2.0~6.0 parts on Flos Carthami; 3.0~8.0 parts of Radix Aucklandiae (Radix Vladimiriae); 3.0~8.0 parts of Fructus Hippophae extractums; 3.0~8.0 parts of Fructus Phyllanthis; 1.0~4.0 parts of Fructus Choerospondiatis; 3.0~8.0 parts of Radix Inulaes; 2.0~5.0 parts of Herba Meconopsis Horridulaes; 2.0~6.0 parts of natural salts; 1.0~4.0 parts of Semen Strychni; 1.0~4.0 parts of Herba Lycopodii; 1.0~4.0 parts of Fructus Rubi corchorifolii Immaturus; 1.0~3.0 parts on Achates.
Above-mentioned Tibetan medicine combination is the basis with the Tibetan medicine and pharmacology theory; Analyze the cause of disease, focus, the disease of modern cardiovascular and cerebrovascular disease and sacred disease from Tibetan medicine's pathologic angle; And on the basis of comprehensive reference modern western medical science, from traditional Tibetan medicine, select common mineral drug and plant amedica to carry out rational proportion to the explanation of cardiovascular and cerebrovascular disease and sacred disease and diagnosis.Gained Tibetan medicine combination drug effect directly acts on human internal organ, and drug effect mainly is presented as four parts: the one, act on teleneuron, and through regulating the nervus vasculairs function, make the vasoconstriction diastole be tending towards normal; The 2nd, blood pressure regulation through promoting cardiovascular normal contraction diastolic function, is safeguarded health of heart; Play the function of blood pressure regulation, make blood pressure recover normal range, can effectively bring high blood pressure down for the hyperpietic; For the hypotensive, can help blood pressure to rise to range of normal value; The 3rd, act on nervus centralis, through regulating cerebral vasodilation, strengthen the blood supply in brain oxygen-supplying amount, the nutrition cranial nerve is regulated the body central nervous system function, and realization is calmed the nerves, the abirritative effect; The 4th, auxiliary drug effect mainly is to reduce the stimulation of medicine to internal organs such as gastrointestinals.
Application and above-mentioned Tibetan medicine that the present invention provides above-mentioned Tibetan medicine to be combined in preparation treatment and the prevention cardiovascular and cerebrovascular diseases medicament simultaneously are combined in preparation treatment and the application that prevents in the neurological disease drug.
Tibetan medicine combination provided by the invention can be applied to prevent and treat cardiovascular and cerebrovascular disease and sacred disease through the clinical trial checking.Cardiovascular and cerebrovascular disease specifically refers to hypertension, hypotension, and hypertensive heart disease.Sacred disease is meant that specifically reveal any symptoms is the neurasthenia of insomnia and hypomnesis, and peripheral nerve disease, and the latter refers to nervus facialis disease or sciatic nerve disease.
The present invention also provides the method for preparing of above-mentioned Tibetan medicine combination simultaneously, and concrete scheme is following:
The method for preparing of above-mentioned Tibetan medicine combination is characterized in that: the former medicine of each component is processed medicated powder according to traditional Tibetan medicine material processing method, again according to need medicated powder being disposed in proportion, add on the pharmaceutics acceptable auxiliary in case of necessity and process different dosage forms.
Tibetan specific combination dosage forms may be administered orally, such as pills, tablets, powders, granules, soups, creams, capsules, tincture, syrup, oil cakes drugs, etc. You concentrated.
Compared with prior art, the invention has the beneficial effects as follows: (1) this Tibetan medicine combined medical material common with tradition in the Tibetan medicine and pharmacology, commonly used is prepared from according to traditional Tibetan medicine concocting method, is that former medicine of medical material or method for preparing are all safe and reliable; (2) the Tibetan medicine Combination application in control cardiovascular and cerebrovascular disease and sacred disease drug effect significantly, short treating period, have no side effect (3) preventing and treating in the application of cardiovascular and cerebrovascular disease with single buck or boost medicine in the past and comparing; Blood pressure stabilization does not rebound after the drug withdrawal, therefore need not to take for a long time.
The specific embodiment
Below in conjunction with embodiment and Test Example, the present invention is further described.
Embodiment one
The preparation of Tibetan medicine combination.
Tibetan medicine combination partner and weight proportion thereof are: 3.0~8.0 parts of Herba Saxifragaes; 1.0~4.0 parts of Stigma Crocis; 1.0~4.0 parts on Corallium Japonicum Kishinouye; 3.0~8.0 parts of Concha Margaritiferas; 0.3~2.0 part of rose beryl; 0.5~2.0 part in ruby; 1.0~4.0 parts on lucky Achates; 2.0~6.0 parts on Flos Carthami; 3.0~8.0 parts of Radix Aucklandiae (Radix Vladimiriae); 3.0~8.0 parts of Fructus Hippophae extractums; 3.0~8.0 parts of Fructus Phyllanthis; 1.0~4.0 parts of Fructus Choerospondiatis; 3.0~8.0 parts of Radix Inulaes; 2.0~5.0 parts of Herba Meconopsis Horridulaes; 2.0~6.0 parts of natural salts; 1.0~4.0 parts of Semen Strychni; 1.0~4.0 parts of Herba Lycopodii; 1.0~4.0 parts of Fructus Rubi corchorifolii Immaturus; 1.0~3.0 parts on Achates.
At first each component raw material is processed into medicated powder, wherein the former medicine of mineral drug component needs at first to be reprocessed into medicated powder through detoxification, specifically:
In the course of processing, adopt the mineral drug detoxification technology of routine in the Tibetan medicine processing to handle earlier Corallium Japonicum Kishinouye, lucky Achates, Achates, ruby, 5 kinds of mineral drugs of rose beryl.Conventional detoxification technology specifically is with JIANHUA (" the Sanitation Ministry medicine standard Tibetan medicine first copy ", standard numbering WS3-BC-0120-95) the aqueous solution soaking 30min of these 5 kinds of mineral drugs with debita spissitudo, takes out and cleans, and is ground into particle diameter 5~6mm granule; With mineral drug and Sal Nitri (" first of the Sanitation Ministry medicine standard Tibetan medicine "; Standard numbering WS3-BC-0020-95), Borax (be recorded in " Chinese pharmacopoeia), Rhizoma Osmundae (be recorded in " Chinese pharmacopoeia), seed of Fructus Hippophae (be recorded in " Chinese pharmacopoeia), Herba Gentianae Urnulae (" first of the Sanitation Ministry medicine standard Tibetan medicine "; Standard numbering WS3-BC-0017-95; Hilllock loud, high-pitched sound fine jade), medical material such as Semen Chebulae (be recorded in " Chinese pharmacopoeia), Moschus (be recorded in " Chinese pharmacopoeia) puts into 10~15 liters of barley wines in the lump and boil 8~10hr with warm fire Tibetan medicine name:; Drain,, dry with tap water flushing 10~15 times; Isolate the mineral drug component at last, grind sieving for standby.The Sal Nitri, the Borax that wherein add are identical with mineral drug weight, and the Rhizoma Osmundae of adding, seed of Fructus Hippophae, Herba Gentianae Urnulae, Semen Chebulae respectively are 1/3 weight of mineral drug, the Moschus 50~80g of adding.
For easy to operate, the former medicine grouping Processing of plant amedica component is become medicated powder, specifically:
With Fructus Phyllanthi, Fructus Chebulae's (enucleation), grind sieving for standby; With Rhizoma Zingiberis, Fructus Choerospondiatis, natural salt, Stigma Croci, Flos Carthami, grind sieving for standby; With Radix Glycyrrhizae, the Radix Aucklandiae, Radix Inulae, Radix Rhodiolae, Lignum Aquilariae Resinatum, Rhizoma Gastrodiae (peeling), grind sieving for standby; With Herba Saxifragae, Herba Meconopsis Horridulae, Radix Salviae Miltiorrhizae, Herba Lycopodii, Fructus Rubi corchorifolii Immaturus, grind sieving for standby; Fructus Hippophae is air-dry, and grinding sieves is equipped with; Semen Strychni mixed with river sand to put to fry in the frying pan to Semen Strychni be golden yellow, separating semen strychni, sieving for standby is ground in peeling.
Above-mentioned medicated powder is all crossed 150 mesh sieves.
Above-mentioned medicated powder is fully processed pill after the mixing in proportion.According to traditional Tibetan medicine processing custom, can outside pill, coat the Lignum pterocarpi indici XIANGFEN, consumption is 3.0~8.0 parts.Lignum pterocarpi indici; Be recorded in " first of the Sanitation Ministry medicine standard Tibetan medicine " (standard numbering WS3-BC-0108-95, Tibetan medicine title: praise dawn agate cloth), main effect is clearing away heat from blood, the blood of cooling down discord; Be used for that warm blood is gone into minute, the stagnant blood stasis of blood is cloudy, wind blood mingles disease, be coated with the podomere swelling that disappears outward.
Embodiment two
The preparation of Tibetan medicine combination.No longer repeat with embodiment one something in common, its difference is:
In order to increase drug effect, Herba Saxifragae, Herba Meconopsis Horridulae, Radix Salviae Miltiorrhizae, Herba Lycopodii, Fructus Rubi corchorifolii Immaturus are plucked local surface water separately with it earlier respectively and are cleaned, and put shady and cool place again and dry, and grind sieving for standby.
Test Example one
Embodiment two makes the application of Tibetan medicine combination pill in treatment and prophylaxis of hypertension disease.
Table 1 high blood pressure disease clinical treatment record
Figure BDA0000070522170000081
Test row two
Tibetan medicine is combined in treatment and the application that prevents in the hypotension.
Table 2 hypotension clinical treatment record
Test Example three
Tibetan medicine is combined in treatment and the application that prevents in the sacred disease.
Table 3 sacred disease clinical treatment record
Figure BDA0000070522170000092
In the above-mentioned Test Example, adverse effect does not appear in patient's (the shortest administration time is 1 month, and length is 6 months) during taking medicine.
Because Tibetan medicine material wide material sources, particularly the mineral drug composition is special, and therefore the former medicine of mineral must carry out strict detoxification operation in the medication preparation process.Prepare experience according to traditional Tibetan medicine, if detoxification is not strict, the Tibetan medicine that makes produces internal organs such as stomaches probably to stimulate, and such side effect does not belong to the toxic and side effects of Tibetan medicine combination of the present invention.

Claims (8)

1. Tibetan medicine compositions; Be made up of mineral medicine and plant medicine, it is characterized in that: said composition weight proportioning is: 3.0~8.0 parts of Herba Saxifragaes, 1.0~4.0 parts of Stigma Crocis, 1.0~4.0 parts on Corallium Japonicum Kishinouye, 3.0~8.0 parts of Concha Margaritiferas, 0.3~2.0 part of rose beryl, 0.5~2.0 part in ruby, 1.0~4.0 parts on lucky Achates, 2.0~6.0 parts on Flos Carthami, 3.0~8.0 parts of Radix Aucklandiae (Radix Vladimiriae), 3.0~8.0 parts of Fructus Hippophae extractums, 3.0~8.0 parts of Fructus Phyllanthis, 1.0~4.0 parts of Fructus Choerospondiatis, 3.0~8.0 parts of Radix Inulaes, 2.0~5.0 parts of Herba Meconopsis Horridulaes, 2.0~6.0 parts of natural salts, 1.0~4.0 parts of Semen Strychni, 1.0~4.0 parts of Herba Lycopodii, 1.0~4.0 parts of Fructus Rubi corchorifolii Immaturus, 1.0~3.0 parts on Achates.
2. Tibetan medicine preparation of compositions method according to claim 1; It is characterized in that: the former medicine of each component is processed medicated powder according to traditional Tibetan medicine material processing method; Again according to need medicated powder being disposed in proportion, add on the pharmaceutics acceptable auxiliary in case of necessity and process different dosage forms.
3. method for preparing according to claim 2; It is characterized in that: said mineral medicine is processed medicated powder through the detoxification PROCESS FOR TREATMENT earlier again, and said Herba Saxifragae, Herba Meconopsis Horridulae, Herba Lycopodii, Fructus Rubi corchorifolii Immaturus clean with the surface water of plucking ground separately respectively and process medicated powder again.
4. according to claim 2 or 3 described method for preparinies, it is characterized in that: said Tibetan medicine compositions is processed pill, and pill is coated the Lignum pterocarpi indici XIANGFEN outward, and Lignum pterocarpi indici XIANGFEN consumption is 3.0~8.0 parts.
5. the application of Tibetan medicine compositions according to claim 1 is characterized in that being applied to treat and prevent the preparation of cardiovascular and cerebrovascular diseases medicament; Or be applied to treat and prevent the preparation of neurological disease drug.
6. application according to claim 5 is characterized in that said cardiovascular and cerebrovascular disease is a hypertension, or hypotension, or hypertensive heart disease.
7. application according to claim 5 is characterised in that: said sacred disease is that reveal any symptoms is the neurasthenia of insomnia or hypomnesis, or peripheral nerve disease.
8. application according to claim 7 is characterized in that: said peripheral nerve disease is the nervus facialis disease, or the sciatic nerve disease.
CN2011101716994A 2011-06-23 2011-06-23 Tibetan medicine composite and application thereof in preparation of medicine for resisting heart cerebrovascular diseases and neurologic diseases Expired - Fee Related CN102225128B (en)

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