CN1426787A - Health care mixture for antifatigne and enhancing immunity - Google Patents

Abstract

A health-care composition for relieving fatigue, improving immunity and resisting anoxide and anemia contains a mixture A with physical adsorbing and slow releasing function, a mixture B for relieving fatigure and improving immunity, a mixture C for assistant mildening function, and a mixture D for balancing and conditioning.

Description

The health care mixture of antifatigne and enhancing immunity

Technical field

The present invention relates to a kind of health product of nutrition antifatigne and enhancing immunity of natural meal supplement dosage form.

Background technology

Chronic fatigue syndrome (CFS) is a kind ofly to continue or show effect repeatedly that half a year, above weak confirmed fatigue was the syndrome of principal character at least.Except that somatization symptoms such as fatigue are arranged, often with mental symptoms such as depression, anxieties.Most personnel mainly show as depression, anxiety, somatization, force that symptom is strong, psychotic disease etc., are in a kind of inferior fatigue state.

Chinese medicine thinks that fatigue belongs to overstrain, deficient category.Tired is because five kinds of strain and seven kinds of impairment causes due to deficient qi and blood, the visceral dysfunction.Spleen governing limbs muscle in each internal organs is the foundation of acquired constitution.The heart controls mental activities blood vessels.Essence and blood is the material base that muscle power produces, and the change of nutrient substance is given birth to and operation has close getting in touch with the traditional Chinese medical science heart, spleen, liver, kidney, and the endurance of human body is also given birth to therefrom, and serves as to produce physical key with the spleen kidney especially.Especially for sports class athletes, its antibody is educated the tired and enhancing sports level of training, the deposit physical ability, and it is very relevant with the nutrient substance that it replenishes to improve competitiveness.

It is a lot of that at present domestic and international antibody is educated the measure of training fatigue and strengthening sports level, forbids product etc. with additional fat milk, aminoacid, sugar, vitamin or the use International Olympic Committee mostly.Improve garrison plateau initial stage altitude sickness and the systemic safeguard procedures of laundering period and be adapted to the master, use dehydrant, diuretic, hormone, nitric oxide suction etc. to prevent and treat radical altitude sickness more with traditional ladder.As seen resisting kinetic fatigue is a kind of protection of passivity with preventing and treating altitude sickness to body, lacks systemic measure, and potential risk factor is higher, and is unbalance as nutrition, endocrine, immunologic function etc., and relevant disease etc.

Especially for female athlete, motility menoxenia is the common sign of female athlete, and along with the increase of the number of women of participating in strenuous exercise, this disease is also more and more many.But the cause of disease is still unclear, and most scholars think that this disease is relevant with too a large amount of endurance exercises, have influenced hypothalamus-hypophysis-gonad axis, suppresses due to ovary generation and the release estrogen and progestogen.

Exercise intensity, quantity of motion, nutriture, body fat thickness decline, anoxia and Deficiency of Intake such as heat, trace element, the tired and mental status is not good etc. all can destroy intravital incretion balance, causes the hypothalamic-pituitary-ovarian s function to be lacked of proper care.Synthesis treatment at first should be supported from the nutrition heat, and balanced nutrients improves sleep and starts with, and symptomatic treatment is consolidated the curative effect resisting fatigue.

Be in the personnel of radiation environment in addition for a long time, because it is unbalance that the radiation meeting influences the every physiological function of body, the unusual rising of hemogram and the variation of following degradation Pathophysiology, multiple factor is mixed in one, be projeced into behavioral activities such as somatization symptom, diet sleep disorder, depression, anxiety and psychotic disease, this negative factor and refreshing essence cause psychosoma illness or CFS to form through accumulating for a long time of refreshing factor.

But dosage radiation environment harmful to human hemopoietic function makes chromosome damage form part, the rising of T cell micronucleus rate.Over-drastic t cell proliferation will damage cellular immune function, and anergic t, B cell increase in the low dose radiation environment, body.

Therefore, functions such as research improvement and enhanced rad environment personnel's hemopoietic, immunomodulating, nutrient substance and the food of regulating apoptotic equilibrium function are the necessary health product that replenish the personnel that are in radiation environment.

Of the present invention open

The objective of the invention is for the health care mixture of a kind of immunity-regulating, anti-exercise fatigue, anoxia enduring, resisting kinetic and malnutritional anemia, the radiating antifatigne and enhancing immunity in anti-plateau is provided.

Purpose of the present invention can realize by following measure:

A kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology;

Wherein: have physical absorption and slow-release function mixture I is made by following raw materials in percentage by weight:

Cortex Cinnamomi 10～38% Rhizoma Dioscoreaes 10～70% Radix Panacis Quinquefoliis 1～20% Semen Cuscutae 0～60%

Radix Pseudostellariae 0～60%;

Antifatigne and enhancing immunity functional mixture II is made by following raw materials in percentage by weight:

Fructus Lycii 4～40% Radix Rhodiolaes 4～20% Lentinus Edodess 5～50% Fructus Schisandrae Chinensis 5～50%

Longan 2～20% Semen Ziziphi Spinosaes 1～30% Folium Mori 5～50% Flos Chrysanthemis 2～15% Semen Cassiaes 2～40%

Flos Lonicerae 2～15% Rhizoma Phragmitiss 5～20% Pericarpium Citri Reticulataes 1～40% Bulbus Lilii 5～40% Poria 5～50%

Semen Coicis 5～50% Fructus Jujubaes 2～20% Radix Glycyrrhizaes 0～15% Fructus Mori 1～25% Fructus Crataegi 0～50%

The Radix Astragali 0～30% Radix Angelicae Sinensis 0～30% Radix Codonopsis 0～20% Herba Epimedii 0～50% Cortex Eucommiae 0～40%;

Assisting a ruler in governing a country gentle functional mixture III is made by following raw materials in percentage by weight:

Fructus Lycii 5～40% circle meat 2～36% Rhizoma Zingiberiss 1～20% Poria 5～30% dried Fructus Vitis viniferae 4～30%

5～50% yuan of meat of Semen Sesami, 5～40% Fructus Jujubaes, 2～60% Radix Panacis Quinquefoliis 0.5～40%

Fructus Schisandrae Chinensis 2～80% Semen Coiciss 10～40% Radix Polygoni Multiflori Preparata 0～40% Semen Cuscutae 0～40%

Cortex Cinnamomi 0～60% Cortex Eucommiae 0～60% Radix Astragali 0～60% Radix Angelicae Sinensis 0～60% Herba Taxilli 0～60%

Radix Polygalae 0～60% Radix Glycyrrhizae 0～60% Herba Epimedii 0～60%

Balance and conditioning functions mixture IV are made by following raw materials in percentage by weight:

Mentha leave 0～60% Fructus Momordicae 0～50% Radix Rhodiolae 0～50% Radix Codonopsis 0～20%

Radix Notoginseng 0～50% Rhizoma Dioscoreae 0～20% Rhizoma Polygonati Rhizoma Pinelliae 0～30% 0～20% Radix Ophiopogonis 0～20%

Bulbus Fritillariae Cirrhosae 0～60% Fructus Ligustri Lucidi 0～60% Herba Cynomorii 0～60% Radix Salviae Miltiorrhizae 0～60% Fructus Cannabis 0～50%

Placenta Hominis powder 0-15%, described Placenta Hominis powder can be the animal Placenta Hominis.

Said mixture thing I is pulverized the CO of back and mixtures II ₂Supercritical extract is by weight 1: (2-10) the mixed A powder that gets; To make B powder and C powder behind mixtures III and the mixture IV pulverize separately; With A powder, B powder, C powder by weight (0.5～8): (0～10): (0～6) is mixed and is got final product.

Purpose of the present invention also can realize by following measure:

The dosage form of described health care mixture can be oral liquid, capsule, pill, tablet, electuary.

When health care mixture was oral liquid or soft capsule, the weight ratio of A powder, B powder, C powder and water, Mel, gelatin was (0.5-8): (0-10): (0-6): (1-20): (0.5-8): (0～15).

When health care mixture was tablet or capsule, the weight ratio of A powder, B powder, C powder and Fructrs Jujubae Powder was (0.5-8): (0-10): (0-6): (1-8).

The present invention has following advantage compared to existing technology:

1, the mixture I in the health care mixture of the present invention has the effect of the effective component nutrient substance of physical absorption mixtures II concurrently, and has the enteral slow-release function concurrently; The slow releasing agent that replaces in the modern pharmaceutical with the effective merit part in plant fine particles such as the Cortex Cinnamomi absorption mixtures II makes the present invention guarantee pure naturalization; And has a vegetalitas anti-corrosion function.

2, mixtures II of the present invention is resisting fatigue, regulates the main formula compatibility of functions such as immunity, mainly extracts composition, as total polysaccharides, total Saponin and phenols etc.

3, mixtures III of the present invention is to the gentle function of assisting a ruler in governing a country of mixtures II; Its function as vitamin, chlorophyll etc., remedies the deficiency by the A powder of mixture I, II preparation for replenishing the composition that loses in the reinforcement process, holds concurrently for body Plant fiber or lignin etc., helps enteral function balance and synthetic vitamin K etc.

4, mixture IV of the present invention both can do auxiliary mixtures II usefulness, also can use separately; The effect of all medicines of compatibility main formula performance adjustment when doing to assist the side; Based on the lung moistening of brain-strengthening tranquilizing by nourishing the heart, conditioning is slept, the effect of blood sugar regulation when becoming main formula separately.

5, each mixture of the present invention is comprehensively made excipient with Fructrs Jujubae Powder, can make when becoming to make tablet or capsule, keeps the pure natural property of its preparation.

6, compatibility resisting fatigue mechanism of the present invention is by balanced nutritious, strengthen and the adjusting immunologic function, improve the body resistivity, improve sports anemia and endocrine, improve the blood viscosity raising and organize oxygen supply, increase holding of liver, inose unit and be equipped with, reduce intravital lactic acid dehydrogenase, creatine creatase level etc., quicken the drainage of interior metabolism product etc., the balance internal milieu, thus reach and improve the recovery of organism fatigue.

Prove through zoopery, highly significant of the present invention ground improvement power exhausts the fatigue recovery of rat and the swimming exercise adaptability on the radical plateau of training rat, it is zero (the matched group mortality rate is 12%) that omnidistance power exhausts training experiment group mortality rate, exceed matched group more than 3 times from the radical swimming time of 1520m 4h to 3785m environment rat, the experimental result prompting, the arterial oxygen content of motion back 1h exceeds about 20 percentage points of matched group, hemorheological indexes is better than matched group, improve cell and the humoral immune function effect is obvious, the histopathologic analysis prompting, the inose unit of animal experimental model rat, liver glycogen stock and organizational structure is better than matched group etc.

The present invention also uses for the military triathlon team member of team altitude environment high strength training of the military region, Lanzhou and the anti-exercise fatigue of participation entire PLA contest, this sports team wins gold medal total first at one stroke, man 10km, the cross-country team in woman 5km mountain region match first, men and women individual triathlon the first, men and women 400m obstacle first etc.

The training of two the international special technical soldiers in the military region, Lanzhou and the military region, Guangzhou, team participating in competition, respectively on the plateau, the Plain, marine, matto, high strength is carried out in regions such as Northern Europe virgin forest, the high-tech difficulty, in ruthlessness field survivorship training and the international tournament, take the present invention and brought into play the resisting fatigue effect, win the 8th international scout's simulation infiltration scouting contest total points first of condition under battle conditions respectively, project sum first, and acquisition race-entry Nobel prize item: " Ka Liefu warrier prize ", with the 9th " 2000 Ai Erna assault " international scout's contest, win project sum first, the good result of group total points first is not seen least bit fatigue by the comment of local news media for Chinese team.

The present invention observes proof through repeatedly radical plateau soldier being protected radical altitude sickness, can obviously improve the acclimatization ability of soldier in 3400m 4400m 5216m and the training of 6000m plateau adaptability, preferentially solved the difficult problem of present domestic and international radical 3000m immunologic function degression of above plateau initial stage, the present invention is that soldier's cellular immune function and departure place (550m) keeps basically identical, reduces sickness rate.Can make radical altitude sickness (AHR) and acute respiratory insufficiency (ARI) and radical altitude sickness (AHAD) incidence rate drop to 25%, and the controlled observation group is 46.6%, the anti-group of medicine is 29.1%.

The above altitude environment sunshine-duration of 3000m is long, and the radiation background is higher than the plains region, all human body is brought harm as the lonizing radiation in cosmic ray, high-energy particle flow, the rock, ultraviolet etc., particularly the potential hazard bone marrow hematogenesis; The present invention finds in intervention radiation personnel's tampering protection research, can make this class personnel's the normal or improvement of routine blood test, and the interleukin-22 level rises, and T cell subsets ratio is normal, and total T cell number increases.

7, the present invention does not contain analeptic, detects through national Olympics analeptic and sport nutrition testing research center, does not contain stimulant, anesthetis, beta blocker, diuretic and the steroid hormone class medicine of International Olympic Committee's regulation forbidding.

8, the present invention has no side effect, and does not contain antiseptic, additive and color element; The safe toxicology of per os poison detects male and female mice LD50 and all belongs to nontoxic level food greater than 20.00g/kg; Can add and subtract coadapted oral liquid of system or soft capsules such as being mixed with suitable motion training initial stage skeletal muscle, cardiopulmonary, gastrointestinal, nervus motorius as required, can be mixed with suitable maintenance training health invigorating in mid-term and accumulate preservation energy, competition term performance level of competition and improve dormant capsule of each phase, tablet or pill; Take or compatibility uses and can reduce radical plateau crowd's altitude sickness incidence rate, strengthen the adaptive capacity under the environment of low oxygen plateau.Can make work instruction young radical 4400m ~ 6200m altitude sickness drop to 25.00% (matched group is 46.67%), (matched group is 81.68% to the blood oxygen saturation 84.21% of 5060m, the anti-group of medicine is 83.79%), femoral artery blood gas analysis partial pressure of oxygen is 40.59% (matched group is 39.91%, and the anti-group of medicine is 40.01%); Special technical soldier was put in the daytime of large amount of exercise, high strength physical training under the various environment hinder incidence rate and drop to (matched group is 29.06 ‰) below 10.00 ‰, the mental fatigue behavior significance such as somatization, anxiety, depression, diet sleep of protection object such as athlete, special technical soldier and inferior tired crowd is alleviated etc.Can make the radical swimming time of 1520m 4h exceed matched group more than 3 times to 3785m environment rat, the experimental result prompting, the arterial oxygen content of motion back 1h exceeds about 20 percentage points of matched group, hemorheological indexes is better than matched group, improve cell and the humoral immune function effect is obvious, histopathologic analysis prompting, the inose unit of animal experimental model rat, liver glycogen stock and organizational structure is better than matched group etc.

9, the present invention is balanced nutritious, is the supplement of nutrients such as indispensable natural vitamin, trace element and the mineral of a kind of human body and anioxidant phytochemicals.

10, lower oxygen concentration resistance of the present invention, resisting fatigue; Strengthen the adaptive capacity under the environment of low oxygen plateau, can make work instruction young radical 4400m ~ 6200m altitude sickness drop to 25.00% (matched group is 46.67%), (matched group is 81.68% to the blood oxygen saturation 84.21% of 5060m, the anti-group of medicine is 83.79%), femoral artery blood gas analysis partial pressure of oxygen is 40.59% (matched group is 39.91%, and the anti-group of medicine is 40.01%); Daytime of special technical soldier large amount of exercise, high strength physical training under various environment is put hinder incidence rate to drop to 12.50 ‰ matched groups is 29.06 ‰, and the mental fatigue behavior significance such as somatization, anxiety, depression, diet sleep of protection object such as athlete, special technical soldier and inferior tired crowd is alleviated etc.

11, the present invention has the two-ways regulation body's immunity; The present invention can improve total T cellular level of animal and human's body, and the expression of IL-2r and NK natural killer cell, improves the contents level of r-INF, TNF, IL-2, IL-6 etc. in the blood; Improve and correct inverted CD4/CD8 ratio, promote anergic t apoptosis etc., human T-cell's apoptosis there is dual regulation, observe when edible I capsule rat power exhausts motion and find, the anti-apoptotic genes expression Bc1-2 of thymus and spleen expresses apparently higher than not edible matched group, and the expression of short apoptogene c-fos is just in time opposite.

12, the present invention has radiation-resisting functional, and the protection radiation environment is to the influence of erythrocyte, leukocyte system, and is particularly evident to hematoblastic improvement.

13, nutrition of the present invention is abundant, contain vegetable protein 27.84～31.23%, fat 2.91～4.13%, carbohydrate 16.56～18.57%, plant nucleic acid 1.82～2.33%, vegetable polysaccharides 3.50～4.65%, total Saponin 3.16～4.20% and aminoacid, vitamin, mineral and dimension secondary element, as, calcium, phosphorus, sodium, ferrum, zinc, selenium etc.

14, the present invention also has the function of conditioning the confusion of the menstrual cycle, has no side effect; Take low dose of estrogen and can in time replenish intravital low estrogen level, solve the balance that the androgen level rises relatively, under mutual the working in coordination with of Chinese medicine, can correct clinical menoxenia, and the reduction risk of CHD do not arranged, make coronary events reduce 50%, reduce bone loss simultaneously, prevent osteoporotic generation.

15, the suitable athlete of the present invention, just go into altitude environment crowd, inferior tired crowd, heavy physical labour and the bad border crowd of hypoxia, the immune dysfunction crowd uses.

Test effect of the present invention:

One, the influence of medical radiation environment personnel's T cell Fas, CD16, CD25 and immune factors such as INF-r, IL-2 and protection thereof are observed

Purpose: observe the influence of immune factors such as intervention radiation diagnosis and treatment personnel T cell Fas (CD95), IL-2R (CD25), CD16 (NK cell) and INF-r, IL-2, IL-6, TNF, IgG, observe the situation of anti-tired I number (I) capsule protection of function of use food front and back simultaneously.Method: select to be engaged in the intervention radiation diagnosis and treatment more than 10 years in 32 personnel's of radiology department protection, outstanding person 10 people of confirmed fatigue symptom are the object of observation; Set up defences and protect preceding group (BG), protection back group (AG), man (CMG) woman (CWG) matched group, the men and women mixes matched group (CG), use T cell Fas, CD25, the CD16 of cells were tested by flow cytometry protection front and back, immunoradiometric assay is measured the cellular immunization factor and IgG etc.Result: BG compares with AG: Fas, WBC, IgG rise, and IFN-r, IL-2, IL-6, TNF, CD16, CD25 all are low level (p＜0.05,0.01); BG compares with CG: IgG, WBC, Fas rise, and IFN, IL-6, TNF, CD16, CD25 all are low level (p＜0.05,0.01), IL-6 not statistically significant.Conclusion: be engaged in the medical radiation environment for a long time in the hemopoietic of harm body, Fas expresses rising, and the cellular immunization factors such as IFN-r, IL-2 descend in CD16, CD25 expression and the blood.The I capsule has tangible two-ways regulation to improve the function of cell, humoral immunization.

The expression of ionization radiation injury cellular immune function and mIL-2R thereof etc., 6～12Gy dosage radiation gamma can make mice Fas express and raise, and apoptosis quickens.The present invention is engaged in intervention diagnosis and therapy work more than 10 years to 10, obvious confirmed fatigue symptom is arranged, peripheral hemogram is unusual, the T cell subsets is lower than the normal population person has carried out the observation of factor levels such as Fas, IFN-r, adopts health product of the present invention to give tampering protection simultaneously, obtains promising result.

1. data and method

1.1 data and grouping: year irradiation dose be among the staff of 32 of the 2～3Gy medical radiation environment of taking conventional protection, selection has the length of service more than 10 years, outstanding person 10 people of confirmed fatigue symptom are the object of observation, set up defences and protect preceding group (BG), protection back group (AG) and non-radiative environment matched group (CG).9 male 1 woman in 10 objects of observation; Be engaged in medical radiation environment work, 〉=10 years person 5 people, the person 2 in 〉=15 years, 〉=25 years person 3 people; Age is 37.20 ± 8.19 years old; Schooling, 3 of undergraduate courses, 6 of junior colleges, 1 of special secondary school.Year participates in intervention diagnosis and therapy 143.30 ± 111.78 times per capita, accumulated dose belongs to the light exposure of a little higher than natural background radiation level, intervening equipment is that Siemens Company produces 2000mA, GIGANTOS, 1000-TRIDORS 1000 type X line medical instrument, each 100-130min.

1.2 protection interference method: to gather the vein anticoagulation on an empty stomach to be measured respectively at taking preceding 1 day of capsule of the present invention and taking after 15 days daystart for each group.Every 0.3g of capsule of the present invention, each 4,3 times/d, ante cibum, eliminating cold for resuscitation water was taken, and took continuously 14 days.

1.3 checkout equipment and reagent: adopt the U.S. to produce the FCSCalibur stream type cell analyzer and measure Fas (CD95), CD16, CD25, reagent C D95-FITC, CD16-FITC, CD25-FITC are Immunotech company product; Adopt U.S. Coda Automated EIA analysis-e/or determining IFN-r, reagent is the IFN-r ELISA of brilliant beautiful from bio-engineering corporation test kit; Adopt the Shanghai nuclear research SN-862 of institute of Chinese Academy of Sciences radioimmunity r-enumerator to measure IL-2, IL6, TNF, IgG, reagent is the RIA of Tianjin Jiuding Bioengineering Co., Ltd. test kit; Adopt Switzerland to produce full-automatic blood cell analyser test peripheral hemogram index.Statistical data all represents that with means standard deviation (x ± s), paired data compares in twos, and row t checks, and p＜0.05,0.01 is for there being the meaning of significance or highly significant.Statistical software uses SPSS10.0.

2. result and analysis

2.1 Fas, CD16, CD25 and IFN-r, IL-2, IL-6, TNF, IgG, WBC the results are shown in Table before and after the protection.Radiate the environmental effect cell immune function of human body from relatively seeing of result, BG, CG compare with reference value, and CD16, CD25 and IFN-r, IL-2, IL-6, TNF totally are descend (p＜0.05,0.01), Fas, IgG, WBC are raise (p＜0.05,0.01); After taking capsule protection of the present invention, AG compares with BG, and Fas, IgG, WBC totally reduce (p＜0.01,0.05), CD16, CD25 and IFN-r, IL-2, IL-6, TNF totally raise, except that IL-6, TNF not statistically significant, remainder all has statistical significance (p＜0.05,0.01).

2.2 case situation and analysis: the hemogram result all lapses to and selects 2 routine document announcements as follows the normal case after 4 protection.

Example 1. certain man, 46 years old, be engaged in radiation work 26 years, doctor, 203 person-times of annual interventions, each 100～120min, (back) is respectively before the protection: Fas:52.89 (19.84 ↓) %, CD16:1.24 (12.11 ↑) %, CD25:1.91 (3.53 ↑) %, WBC:12.3 (8.7 ↓) 109/1, PLT:68 (89 ↑) 109/1, LYM:3.6 (2.6 ↓) 109/1, MON:1.1 (0.6 ↓) 109/1, GRA:7.6 (5.5 ↓) 109/1, IFN-r:46.04 (52.32 ↑) pg/ml, IL-2:3.53 (5.66 ↑) ng/ml, IL-6:50.77 (72.86 ↑) pg/ml, TNF:0.34 (0.57 ↑) ng/ml, IgG:13.29 (15.64 ↑) ug/ml.

Example 2. certain man, 37 years old, the doctor was engaged in radiation work 15 years, and annual the participation got involved 127 person-times, each 100～120min, (back) Fas:2.93 (48.84 ↑) % before the protection, CD16:17.53 (21.08 ↑) %, CD25:2.68 (4.06 ↑) %, WBC:8.3 (6.8 ↓) 109/1, PLT:26 (57 ↑) 109/1, LYM:2.9 (1.7 ↓) 109/1, MON:0.6 (0.4 ↓) 109/1, GRA:4.8 (3.0 ↓) 109/1, IFN-r:27.17 (46.04 ↑) pg/ml, IL-2:4.56 (4.64 ↑) ng/ml, IL-6:52.39 (50.44 ↓) pg/ml, TNF:1.41 (1.13 ↓) ng/ml, IgG:16.70 (16.66 ↓) ug/ml.

Above-mentioned two routine data are individual intravital adjusting situations of the body before and after the protection interior Fas, CD16, CD25, IL-2, IL-6, TNF, WBC, PLT etc., ↑ expression is raised, ↓ expression downward modulation, two-way immunoregulation effect is fairly obvious behind the visible I capsule tampering protection.Situation analysis from each case, the Fas expression was before the respondent protected: 42.94～69.20% 5 examples, 2.93～39.20% 5 examples, protection back 12.03～30.17% 8 examples, 51.46～53.07% 2 examples, all in 15.96～35.53% normal range, the reagent term of reference is 13.0～28.9% to matched group.Timing under the simultaneously visible Fas, TNF, IL-6 raise, the last timing of Fas, TNF, IL-6 downward modulation.

3. discuss

It is long-armed that people Fas gene is positioned at No. 10 chromosomes, cDNA total length 2534bp, and coding contains 335 amino acid whose glycosylation receptor proteins, is TNF/NGF receptor family member, and about 70 aminoacid of its cytoplasmic domain are that Fas and TNF-R1 conduction apoptotic signal are necessary.After human body is subjected to 0.5～6Gy irradiation, peripheral blood lymphocyte is cultivated back mIL-2R and is expressed with dosage increasing and minimizing gradually, the radiation gamma B6 of human 1.5Gy such as Reap and lpr mice, observing ray finds during apoptosis thymus and splenic T, B, two apoptosis has all taken place, the former is 73%, and the latter 25%, but Thy, CD4, CD8, IgG positive cell group cell Fas express the apoptosis rate zero difference.6～12Gy dosage radiation gamma can make mice Fas express raise, and apoptosis quickens, show radiation after lymphocyte the Fas mediated Apoptosis has taken place.The immunosuppressive action of ionizing radiation is proved already, but low dose radiation is to human T-cell's subgroup, and the data that Fas, CD25, CD16 and IFN-r, TNF, IL-6 etc. change is rare.

This result of study confirms, the low dose radiation environment can make the Fas expression of T cell and WBC, the IgG in the human peripheral raise, CD16, CD25 express decline, and immune factor levels such as IFN-r, IL-2, IL-6, TNF are starkly lower than normal population and matched group (p＜0.05,0.01) in the blood; This phenomenon and radiation environment harm hemopoietic function, the report that makes chromosome damage form part, the rising of T cell micronucleus rate has concordance.Show that over-drastic t cell proliferation will damage cellular immune function, during bibliographical information neutrophilic granulocyte generation apoptosis, CD16 expresses decline, and the inventor thinks the low dose radiation environment, anergic t, B cell increase in the body, WBC is the overall compensatory rising of non-inflammation performance, and it is the signal that the body autonomic balance is regulated that Fas expresses rising.This may be that CD16 express to reduce, and cause phagocyte to the engulfing and natural immunity function reduction of apoptosis neutrophilic granulocyte, or because radiation damage has influenced the growth and the immunoloregulation function thereof of immune cell.Lipopolysaccharide, IFN-r, IL-1, IL-6, IL-8 etc. can both significantly suppress neutrophil apoptosis in vivo, and the CD95 downward modulation is the sign that apoptosis activity reduces.Every observation index behind the tampering protection is carried out in this research all in various degree improvement or good lapsing to, capsule of the present invention has the effect of tangible raising cellular immunization factor IFN-r, IL-2, IL-6, TNF and CD16, the expression of CD25 molecular level, and Fas, WBC, IgG all reduce.

Two, the change of radical plateau soldier T cell subsets, RBC system etc. and vim and vigour respiratory function is observed with protection

Purpose: observe the change of radical plateau soldier T cell subsets, RBC, PLT and WBC and vim and vigour, respiratory function, and use the influence of self-control functional food III capsule protection acute high altitude reaction (AHR)/acute respiratory insufficiency (ARI).Method: from being to be divided at random the 360 routine young soldiers of the radical plateau 2260m of 555m, 2900m, 3200m, 4400m, 4800m by landlocked height above sea level, III capsule in prevention and treatment group (AG), compound rhodiola root (RCO) control group (RG), each 120 example of placebo (PCO) matched group (CG), 24h takes III capsule, RCO, PCO respectively before all radical plateau.Take a sample test at random at 3200m, 4400m respectively and respectively organize femoral artery vim and vigour, T cell subsets, hemocyte, pulmonary function variation etc.The result: the AHR/ARI example number AG and the RG of two height above sea levels are starkly lower than the CG group, and T cell subsets AG group and RG, CG group all have significance and significant differences etc.RBC WBC HGH CTH in the hemogram all has different difference variation etc.Conclusion: radical plateau influences the T cell function and is irregular variation, and the III capsule can obviously strengthen radical plateau soldier's T cell function and stability thereof, and the adaptability on the radical plateau of enhancing body and resistance reduce altitude sickness.

China above highlands of height above sea level 3000m occupies land, territory 1/6, the plateau military operation, and construction west plateau and exploitation tourist industry money are former, all need human resources's garrison.People from Plain enters behind the 3200-3800m 5 days, and PHA causes that lymhocyte transformation rate reduces, and the T cell function is impaired.The capsule of the present invention that this observational study uses is on the tired basis of achieving success of the military triathlon training of inventor's anti-high strength under altitude environment, according to radical 3000m above plateau characteristics and improved a kind of functional food.It has played and has strengthened preferably and regulate the body's immunity effect, is obtaining than promising result aspect protection acute high altitude reaction (AHR)/acute respiratory insufficiency (ARI).

Object and method

1. object of study and grouping: add up to 1223 routine officers and men groups anti-in, concentrate and inspected three team's 360 examples, male by random samples, 21 ± 1.89 years old age was divided into three groups of AG, RG, CG at random, each 120 example, all 24h takes capsule of the present invention, RCO, PCO respectively before radical plateau, continuously 13-15 day.

2. radical mode and time: object of study is moved into 2260m by the motorized 24h in landlocked height above sea level 555m campsite, moves into 2900m after 2 days, moves into 3200-3700m after 3 days, moves into 4400-5200m after 4 days again.

3. test item, equipment and standards of grading: stochastic sampling is measured the T cell subsets, adopting the U.S. to produce the FCSCalibur stream type cell analyzer measures, reagent is Immunotech company product, CD3-FITC, CD4-FITC, CD8-FITC, detect femoral artery vim and vigour (Switzerland produces the full-automatic portable blood gas analyzer of AVL-OPT-1), measure erythrocyte in the femoral artery blood, platelet and numeration of leukocyte (Switzerland produces full-automatic blood cell analyser), test lung merit FEV1, FVC, FEF50, MVV (U.S. produces the portable lung merit of Compact-I and measures automatic analyzer), standards of grading are recommended original text with reference to entire PLA's plateau meeting and the 3rd national plateau medicine meeting.Above-mentioned detection technique professional division is implemented.

4. statistical procedures: relevant data represents that with means standard deviation paired t-test and mean compare in twos, P value＜0.05, and＜0.01 defines significance.

The result

1. radical two height above sea level femoral artery blood T cell subsets results show that CD3, the CD4 of AG, CG group, CD8 are rising and constant with the height above sea level rising, and each value of GR group is downward trend, but is tending towards relative inhibitory state generally; The CD3 of RG, CG is in relative inhibition during 3200m, begins to occur the active trend that rises in the 4400mCR group, but the relative AG of range of the sample (54.05～77.96) group is drawn together big (56.55～81.77); CD4/CD8 AG, RG group is in rising trend, and CG organizes decline.In general, two prevention groups are stable, the matched group variation big rise and fall that seems.

2. two height above sea level femoral artery blood gas analysis results show that respectively organizing PaO2 all descends with the height above sea level rising, and variation tendency is comparatively stable.Two control groups are apparently higher than matched group.Also variant between two control groups.

3. two height above sea level erythrocyte, leukocyte and platelet result show that RBC (erythrocyte), HGB (hemoglobin), WBC (leukocyte) between each group do not have statistical significance, on the surface, the AG group is overall to rise, and RG organizes decline, CG group RBC rises, and HGB, WBC descend; HCT (packed cell volume) AG group all is lower than RG, CG group; MCV (mean corpuscular volume) is lower than RG, CG group in the 3200mAG group, and 4400m AG, CG organize basically identical, and the RG group raises relatively; MCT (packed cell volume) AG group is alive to be occupied between 45～48% peaceful protoplasts' the upper limit of Tibetan, and two groups of RG, CG are all on the upper limit of migrating Han nationality 50～52%; The situation of change of respectively organizing data variation and T Lymphocyte Subsets Determination on the whole is similar, and two prevention groups are relatively stable, and the matched group fluctuation is bigger.But angle from clinical meaning, at 3200m the macrocytic anemia tendency is arranged in two gradient CG group in the RG group, the MCH of matched group (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin) also are decline, the tendency that low pigment anemia is arranged, RDW (erythrocyte width distribution) CG, the RG group all is higher than the AG group, erythrocytic size variation strengthens day by day during iron deficiency, the RDW value raises, illustrate that the III capsule can replenish the ferrum deficiency when the compensatory hemoglobin raises in the radical plateau, the effect of resisting kinetic anemia has been brought into play effect at this.From the variation of PLT (platelet count), PCT (platelet specific volume), the prevention group rises obviously, and matched group rises at 3200m, 4400m descends, it is the trend that true sexual cell increases that PLT increases, and Fe stocks deficiency in prompting matched group and the RG group body, but the RG group is better than matched group.

4. two height above sea level pulmonary function results show that the control group of two height above sea levels and matched group raise with gradient and on a declining curve at FEV1, FVC, and not statistically significant between each group of FEV1, FVC, AG, RG compare with the CG group all significant difference, FEF50, the MVV of CG group have unsymmetry rising trend, it is not remarkable that AG, RG change, and prompting CG has the vicarious respiration frequency to increase and the FEF50 peak value increases due to curve moves to left.

The incidence rate of (5.AHR/ARI/AHAD radical altitude sickness): AHR/ARI person is taken place and is followed successively by in three groups of radical 3200m of AG, RG and CG: 4/124,3/120,9/120, each group accumulative total is after arriving at 4400m: 30/120 (25%), 35/120 (29.1%), 56/120 (46.6%), amount to 121/360 (33.61%) AHR takes place.Wherein obvious AHR or pulmonary edema take place in 11 examples, and cerebral edema need be treated, and wherein the CG group accounts for 9 examples, and AG and RG group respectively account for 1 example.

Discuss

1. radical plateau and T cell change: present most scholars think that entering behind the plateau T cell function impaired [1] people from Plain with the Plain enters behind 3200～3800m 5 days, lymhocyte transformation rate reduces, recover normal after 25 days, decompression simulation 7620m is the synthetic and picked-up minimizing of 3H-TdR in the time of 90 days, 2121m is high, and principle is constant, proves that high high lymphoblast generates minimizing.The T cell subsets at radical the 8th day 3200m and the 11st day 4400m two places has been measured in this research, CD3 and the AG protection group ratio of finding the 8th day CG observation group and RG protection group are suppressed, all at Plain people's streaming cell method normal reference value 69.98 ± 5.79 lower limits, with above-mentioned data identical part is arranged, the 4200mCG group rose in the 11st day, and scope is bigger, and the RG group continues to descend, the AG group is held constant little on the rise substantially, and the CG group has opposing part with above-mentioned data.These may be different with method, and the not equal factor of specimen is relevant.Clinical manifestation from protection AHR/ARI, AG, RG will organize significantly better than CG for two groups, total T cell of AG group is apparently higher than RG group (p＜0.05 or＜0.01), and prompting RG group might be to adapt to the plateau initial reaction by reducing various metabolism, AG group and different with it.

Long-time high-intensity exercise can lower CD4, CD8 ratio, and the author takes anti-fatigue nutrient drink person and matched group in the high strength large amount of exercise resisting kinetic fatigue in the 2366m environment CD4/CD8 has significant difference.The AG group is used the protection of III capsule, and function stable or enhancing T cell is obvious.The enhancing of T cell subsets function can promote the growth of all kinds of immune factors generations and immunocyte, participates in immunomodulating, mediates delayed hypersensitivity and kills and wounds the target cell effect.Inventor's certain plant extract in laboratory confirmation capsule of the present invention can be expressed natural immunity materials such as r-interferon at the external people's quasi-lymphocyte that induces, and whether can produce the endogenous immune material and be still waiting further research.

2. the effect of capsule protection ARI/AHR of the present invention.The young soldier of the healthy landlocked 555m of 360 examples is observed in this protection, divides 3 groups of radical plateau 2260m under the same conditions, 2900m, and 3200m, 4400m returns 4400m and camps in arrival 4800m, 5200m place on the 10th.Three groups of AHR of AG.RG.CG accumulative total incidence rate is 30/120,35/120, and 56/120.ARH/AHAD is followed successively by 1/120,1/120,9/120 wherein the CG group slight pulmonary edema, cerebral edema 9 examples take place, send treatment after each 1 example of protection group is accepted, visible protection group effect is remarkable.

Three, the medical treatment of altitude environment military sports campaign training female team member menoxenia

Purpose: solve the menoxenia problem of the military triathlon training of woman team member under the altitude environment, guarantee training plan is finished smoothly.Method: instruct team member's science diet balanced nutrients, carry out comprehensive conditioning, be i.e. assessment and after treatment effect before and after therapy of combining Chinese and Western medicine, psychology (SCL-90) self-appraisal scale are treated, the generation of control overtraining syndrome.Result: T, Hb, RBC, etc. all after medical treatment, improve significantly (P＜0.01, P＜0.05), WBC has downward trend (P＜0.01) etc., SCL-90 result shows diet sleep, somatization, forces symptom to improve.Conclusion: think that the sign that menoxenia promptly is early stage overtraining appears in woman's fortune merit person, combination therapy of Chinese and western has very big potentiality.Exercise intensity, quantity of motion, nutriture, body fat thickness decline, anoxia and Deficiency of Intake such as heat, trace element, the tired and mental status is not good etc. all can destroy intravital incretion balance, causes the hypothalamic-pituitary-ovarian s function to be lacked of proper care.Synthesis treatment at first will be supported from the nutrition heat, and balanced nutrients improves sleep and starts with, and symptomatic treatment is consolidated the curative effect resisting fatigue.

6 military triathlon team members that menoxenia takes place after we assembled for training six months down to height above sea level 1570～2366m environment recuperate under medical treatment, and obtain ideal effect, have improved agonistic sports level and ability, reach and have cut the throat more phase purpose, and won ranking in contest.Now be reported as follows:

1. basic document and method

1.1 basic document: the age is that menoxenia appears in 6 team members among 19～21 years old 13 of the outstanding woman triathlon persons, accounts for the team member's that undergoes training 46.15%, has had a strong impact on finishing of training plan.It is surplus June to have experienced big intensity training and military region selective trial, and menstrual cycle is 10.16 ± 3.49 days.The nutriture result, height is 165.83 ± 3.43cm, body weight is 56.75 ± 2.93kg, body fat thickness is 23.34 ± 1.73%, the body lipid density is 1.04054 ± 0.01162, the whole absorption of female team member heat is 11.62 ± 0.29 (MJ), recommends pay standard to differ about 10% deficiencies such as the vitamin B group of absorption, folic acid, peas protein, the C that supports one's family, trace element zinc, copper with the country and the army of this type games.The laboratory examination routine blood test is roughly normal, and list 8 observation indexs and see Table 1, the SCL-90 test result is represented, female team member's somatization, force the factors such as symptom, diet sleep, anxiety to divide to raise, score value is respectively 1.89 ± 0.59, and 2.27 ± 0.45,2.16 ± 0.62,1.78 ± 0.56, each score value and China youth's norm have significant differences (P＜0.01).

1.2 method

1.2.1 instruct the science diet balanced diet to use nutrition microcomputer science to formulate everyone standard intake, guarantee heat energy, all kinds of nutrient capacity and balance, and dining and nutrition are intervened, whenever oral before the meal the present invention 40～50ml, oral VitC100mg 3/ day, the plain B2 sheet of composite microbial, 3/ day, sulphuric acid zinc metal sheet 5mg, 2/ day, calcium gluconate 0.5g, 2/ day, inosine sheet 0.2g, 3/ day.Must eat making the grade, night snack fresh milk 300～400ml.

1.2.2 use Self-reporting inventory (SCL-90) to treat the front and back assessment, notice that psychological counseling solves psychosoma illness problem.

1.2.3 treatment is 1. conventional: 30min oral melatonin 2～3mg before sleep difference person gives to sleep every night, or diazepam 5～10mg.Low discharge oxygen uptake 20min 2/, suitably adjusts training strength.2. Chinese medicine and western medicine conditioning is used folk remedy: each 20g oven dry porphyrize such as Chinese medicine Rhizoma Chuanxiong, stir-fry Pu, Fructus Aurantii, Lignum Aquilariae Resinatum, Fructus Trichosanthis is stand-by.10g, 2/, warm boiled water was joined diethylstilbestrol 1mg, and 1/, with obeying 22 days, one week of the drug withdrawal person of bleeding was considered as effective or clinical meaning is arranged.Treated menstrual onset 5～7, and continued for second course of treatment.

2. result

6 routine menstruations all recover normally after above-mentioned conditioning two courses of treatment, and menstrual cycle is 27.17 ± 1.47 days per capita.8 index situations before and after the conditioning see Table 1.Serum testosterone (T), hemoglobin (Hb), red blood cell count(RBC) (RBC), etc. (P＜0.01 that all after medical treatment, improves significantly, P＜0.05), WBC has downward trend (P＜0.01) estradiol (E2), flesh liver (Cr), serum ferritin (SF) to rise obviously, but not statistically significant (P＞0.05), hydrocortisone (Cort) no change.SCL-90 result shows sleep diet, somatization and force symptom to have clear improvement, and the factor is divided into 1.89 ± 0.75,1.77 ± 0.72,1.88 ± 0.51, downward trend arranged but do not have statistical significance (P＞0.05), anxiety be 1.76 ± 0.60 improve still not obvious.Clinical symptoms obviously improves, and competitiveness improves gradually, has guaranteed the unified implementation of training plan.

3. discuss

3.1 the cause of disease, the motility menoxenia common sign that is female athlete, along with the increase of the number of women of participating in strenuous exercise, this disease is also more and more many.But the cause of disease is still unclear, and most scholars think that this disease is relevant with too a large amount of endurance exercises, have influenced hypothalamus-hypophysis-life gland axle, suppresses due to ovary generation and the release estrogen and progestogen.We use the result of aggregate measures conditioning comparatively desirable, also support this viewpoint.Exercise intensity, quantity of motion, nutriture, the decline of body fat, anoxia and Deficiency of Intake such as heat, trace element, the tired and mental status is not good etc. all can destroy intravital incretion balance, causes the hypothalamic-pituitary-ovarian s function to be lacked of proper care.The capital causes the menoxenia of young female athlete.These team members big intensity and endurance training through lasting six months, and the selective trial in the military region, force the factors such as symptom, sleep diet to divide to raise at somatization, and prompting has the psychosoma fatigue problem; Estradiol level hangs down 16.67～54.52pmol/L (normal reference lower limit 132pmol) than normal population reference lower limit in the blood, and testosterone is near the normal value upper limit level; Data prompting body fat thickness 20% just can be kept normal menstrual cycle [4], we find female team member's heat, some nutrient Deficiency of Intake in nutritional survey, though body fat is in normal range (23.34 ± 1.75%), but carry out the super endurance training of big intensity under altitude environment, this body fat thickness can not be kept female team member's normal menstrual cycle.T, RBC situation from the blood of treatment front and back, the rising of T, RBC has the difference (P＜0.01) of highly significant, Hb has significant difference (P＜0.05), E2, Cr, SF are on the rise on the surface, but not statistically significant (P＞0.05), and WBC has downward trend and the meaning (P＜0.01) of highly significant is arranged.Be not difficult to find out that low relatively T mass formed by blood stasis phenomenon has appearred in the team member before treatment, WBC is on the rise etc., and it is too short that these 6 woman team members mainly show as menstrual cycle, points out early stage overtraining sign to exist.

3.2 know from experience 1. nutrition heat support and balanced diet is the basis of treatment menoxenia, and it is crucial improving sleep, and strengthening prevention in the time of active treatment is to guarantee that psychological counseling is very important.2. Chinese medicine proved recipe and the low dose of estrogen effect of replenishing, is fried Pu and is had nourishing blood for regulating menstruation, heat-clearing and toxic substances removing the Rhizoma Chuanxiong in the side, the promoting blood circulation to restore menstrual flow circulation of qi promoting positive pain of dispeling the wind, the effect of consolidating channel for hemostasis, Fructus Aurantii, Lignum Aquilariae Resinatum the is adjustable branch of regulating the flow of vital energy, dredge smooth mechanism of qi, the circulation of qi promoting sending down the abnormal ascending QI, puckery and do not stagnate, but Fructus Trichosanthis, Talcum clearing away summer-heat diuresis, Qinghua heat-phlegm, tonneau two just can be eliminated the compressing to the uterus, the collaborative blood of taking the photograph.We also have the function of postponing menstrual cycle, have no side effect.Low dose of estrogen can in time replenish intravital low estrogen level, solve the balance that the androgen level rises relatively, the clinical menoxenia of collaborative mutually correction down at Chinese medicine, and the reduction risk of CHD do not arranged, make coronary events reduce 50%, reduce bone loss simultaneously, prevent osteoporotic generation.3. improve the important step that sleep is the conditioning menoxenia, especially be good to use melatonin, oral stable class medicine has certain side effect, is unfavorable for the daystart training, melatonin has many-sided physiological function, studies have shown that melatonin is regulated reproductive system and reproductive function by thalamus-hypophysis-gonad axis, when recovering the menstruation rule, improve the immunomodulating of body, anti-inflammatory and antalgic, antioxidation and improving outside the function such as neurological symptom also can promote to recover sports fatigue.4. preventing sports fatigue is the after treatment effect, improves the important assurance of the level of training.Adhere to taking anti-tired nutrition drink, this kitchenware has spleen benefiting and stimulating the appetite, feel at ease to repose, and the YIN nourishing hemopoietic, soothing the liver making eye bright, promoting the production of body fluid to quench thirst, the refreshment of regulating the flow of vital energy, and increase effect such as immunologic function.Can make sports fatigue recovery within a short period of time or fatigue not occur, keep preferable big intensity and endurance training state, improve competitive ability.

Embodiments of the present invention

The present invention also will be described in further detail in conjunction with the embodiments:

Embodiment one:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 30%, Rhizoma Dioscoreae 68%, Radix Panacis Quinquefolii 2%, Semen Cuscutae 0%, Radix Pseudostellariae 0%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, Radix Rhodiolae 5%, Lentinus Edodes 6%, Fructus Schisandrae Chinensis 33%, longan 3%, Semen Ziziphi Spinosae 2%, Folium Mori 6%, Flos Chrysanthemi 3%, Semen Cassiae 3%, Flos Lonicerae 3%, Rhizoma Phragmitis 6%, Pericarpium Citri Reticulatae 2%, Bulbus Lilii 6%, Poria 6%, Semen Coicis 6%, Fructus Jujubae 3%, Radix Glycyrrhizae 0%, Fructus Mori 2%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, circle meat 2%, Rhizoma Zingiberis 2%, Poria 6%, dried Fructus Vitis viniferae 4%, Semen Sesami 5%, first meat 5%, Fructus Jujubae 2%, Radix Panacis Quinquefolii 1%, Fructus Schisandrae Chinensis 58%, Semen Coicis 10%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 58%, Fructus Momordicae 5%, Radix Rhodiolae 10%, Rhizoma Dioscoreae 5%, Radix Codonopsis 10%, Radix Notoginseng 5%, Rhizoma Polygonati 7%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method be with mixture I, III, IV after washing, 80-140 ℃ of following drying and crushing to the 150-200 order; With mixtures II washing, 80-140 ℃ of oven dry down, pulverize to put into and extract still, at pressure 10-25Mpa, temperature 4-55 ℃, time 45-120 minute, entrainer 95% ethanol, high-pressure pump adds CO ₂, utilize CO ₂Supercritical extraction is carried 3-4 time; Under 4-45 ℃, water is carried 30-120 minute again, repeats water and carries 3-5 time, the centrifugal decontamination of extracting solution is sneaked into mixture I mixes thoroughly, spray drying becomes the A powder; The CO of mixture I and mixtures II wherein ₂The weight ratio of supercritical extract 1: 5.

The preparation of present embodiment is an oral liquid, and the weight ratio of each raw material of oral liquid is: the A powder: the B powder: C powder: water: Mel=8: 0: 0: 10: 6.

Embodiment two:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 10%, Rhizoma Dioscoreae 40%, Radix Panacis Quinquefolii 10%, Semen Cuscutae 40%, Radix Pseudostellariae 0%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 33%, Radix Rhodiolae 4%, Lentinus Edodes 6%, Fructus Schisandrae Chinensis 6%, longan 3%, Semen Ziziphi Spinosae 2%, Folium Mori 5%, Flos Chrysanthemi 2%, Semen Cassiae 2%, Flos Lonicerae 3%, Rhizoma Phragmitis 5%, Pericarpium Citri Reticulatae 3%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 5%, Fructus Mori 2%, Fructus Crataegi 2%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 20%, circle meat 3%, Rhizoma Zingiberis 10%, Poria 5%, dried Fructus Vitis viniferae 5%, Semen Sesami 6%, first meat 6%, Fructus Jujubae 3%, Radix Panacis Quinquefolii 2%, Fructus Schisandrae Chinensis 3%, Semen Coicis 20%, Radix Polygoni Multiflori Preparata 10%, Semen Cuscutae 7%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 26%, Fructus Momordicae 24%, Radix Rhodiolae 4%, Rhizoma Dioscoreae 18%, Radix Codonopsis 2%, Radix Notoginseng 22%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 4%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 8; All the other all with example together

The preparation of present embodiment is a soft capsule, and the weight ratio of each raw material of soft capsule is: the A powder: the B powder: C powder: water: Mel: gelatin=6: 8: 4: 1: 0.5: 10.

Embodiment three:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 12%, Rhizoma Dioscoreae 12%, Radix Panacis Quinquefolii 20%, Semen Cuscutae 28%, Radix Pseudostellariae 28%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, Radix Rhodiolae 4%, Lentinus Edodes 6%, Fructus Schisandrae Chinensis 5%, longan 3%, Semen Ziziphi Spinosae 2%, Folium Mori 33%, Flos Chrysanthemi 2%, Semen Cassiae 2%, Flos Lonicerae 3%, Rhizoma Phragmitis 5%, Pericarpium Citri Reticulatae 3%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 0%, Fructus Mori 2%, Fructus Crataegi 0%, the Radix Astragali 7%, Radix Angelicae Sinensis 1%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 10%, circle meat 32%, Rhizoma Zingiberis 5%, Poria 5%, dried Fructus Vitis viniferae 4%, Semen Sesami 5%, first meat 5%, Fructus Jujubae 3%, Radix Panacis Quinquefolii 10%, Fructus Schisandrae Chinensis 5%, Semen Coicis 10%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 6%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 2%, Fructus Momordicae 43%, Radix Rhodiolae 25%, Rhizoma Dioscoreae 2%, Radix Codonopsis 18%, Radix Notoginseng 2%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 4%, Bulbus Fritillariae Cirrhosae 4%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 10; All the other all with example together

The preparation of present embodiment is a tablet, and the weight ratio of each raw material of tablet is: the A powder: the B powder: the C powder: Fructrs Jujubae Powder=4: 10: 6: 8.

Embodiment four:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 25%, Rhizoma Dioscoreae 26%, Radix Panacis Quinquefolii 15%, Semen Cuscutae 10%, Radix Pseudostellariae 24%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, Radix Rhodiolae 18%, Lentinus Edodes 6%, Fructus Schisandrae Chinensis 5%, longan 2%, Semen Ziziphi Spinosae 1%, Folium Mori 10%, Flos Chrysanthemi 2%, Semen Cassiae 2%, Flos Lonicerae 2%, Rhizoma Phragmitis 5%, Pericarpium Citri Reticulatae 20%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 0%, Fructus Mori 1%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 4%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 35%, circle meat 5%, Rhizoma Zingiberis 1%, Poria 5%, dried Fructus Vitis viniferae 4%, Semen Sesami 5%, first meat 5%, Fructus Jujubae 20%, Radix Panacis Quinquefolii 2%, Fructus Schisandrae Chinensis 2%, Semen Coicis 11%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 5%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 15%, Fructus Momordicae 2%, Radix Rhodiolae 48%, Rhizoma Dioscoreae 10%, Radix Codonopsis 5%, Radix Notoginseng 10%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 10%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 2; All the other all with example together

The preparation of present embodiment is a capsule, and the weight ratio of capsular each raw material is: the A powder: the B powder: the C powder: Fructrs Jujubae Powder=2: 4: 3: 4.

Embodiment five:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 36%, Rhizoma Dioscoreae 55%, Radix Panacis Quinquefolii 5%, Semen Cuscutae 2%, Radix Pseudostellariae 2%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, Radix Rhodiolae 4%, Lentinus Edodes 5%, Fructus Schisandrae Chinensis 5%, longan 2%, Semen Ziziphi Spinosae 1%, Folium Mori 5%, Flos Chrysanthemi 14%, Semen Cassiae 20%, Flos Lonicerae 2%, Rhizoma Phragmitis 10%, Pericarpium Citri Reticulatae 2%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 0%, Fructus Mori 1%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 7%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 15%, circle meat 15%, Rhizoma Zingiberis 15%, Poria 6%, dried Fructus Vitis viniferae 5%, Semen Sesami 5%, first meat 6%, Fructus Jujubae 10%, Radix Panacis Quinquefolii 5%, Fructus Schisandrae Chinensis 5%, Semen Coicis 10%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 3%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 45%, Fructus Momordicae 10%, Radix Rhodiolae 15%, Rhizoma Dioscoreae 1%, Radix Codonopsis 1%, Radix Notoginseng 1%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 12%, Fructus Cannabis 0%, Placenta Hominis powder 15%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 6; All the other all with example together

The preparation of present embodiment is a soft capsule, and the weight ratio of each raw material of soft capsule is: the A powder: the B powder: C powder: water: Mel: gelatin=1: 6: 0: 2: 2: 14.

Embodiment six:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 11%, Rhizoma Dioscoreae 11%, Radix Panacis Quinquefolii 18%, Semen Cuscutae 0%, Radix Pseudostellariae 60%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 4%, Radix Rhodiolae 4%, Lentinus Edodes 5%, Fructus Schisandrae Chinensis 6%, longan 10%, Semen Ziziphi Spinosae 15%, Folium Mori 5%, Flos Chrysanthemi 3%, Semen Cassiae 2%, Flos Lonicerae 2%, Rhizoma Phragmitis 5%, Pericarpium Citri Reticulatae 1%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 0%, Fructus Mori 21%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 6%, circle meat 10%, Rhizoma Zingiberis 3%, Poria 20%, dried Fructus Vitis viniferae 10%, Semen Sesami 6%, first meat 5%, Fructus Jujubae 5%, Radix Panacis Quinquefolii 18%, Fructus Schisandrae Chinensis 2%, Semen Coicis 10%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 5%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 10%, Fructus Momordicae 32%, Radix Rhodiolae 38%, Rhizoma Dioscoreae 13%, Radix Codonopsis 7%, Radix Notoginseng 3%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 7%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 4; All the other all with example together

The preparation of present embodiment is an oral liquid, and the weight ratio of each raw material of oral liquid is: the A powder: the B powder: C powder: water: Mel=3: 2: 1: 4: 8.

Embodiment seven:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 16%, Rhizoma Dioscoreae 16%, Radix Panacis Quinquefolii 8%, Semen Cuscutae 60%, Radix Pseudostellariae 0%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 4%, Radix Rhodiolae 5%, Lentinus Edodes 5%, Fructus Schisandrae Chinensis 5%, longan 2%, Semen Ziziphi Spinosae 1%, Folium Mori 6%, Flos Chrysanthemi 3%, Semen Cassiae 3%, Flos Lonicerae 14%, Rhizoma Phragmitis 15%, Pericarpium Citri Reticulatae 1%, Bulbus Lilii 5%, Poria 12%, Semen Coicis 5%, Fructus Jujubae 2%, Radix Glycyrrhizae 0%, Fructus Mori 2%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 5%, Radix Codonopsis 0%, Herba Epimedii 5%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 8%, circle meat 4%, Rhizoma Zingiberis 2%, Poria 7%, dried Fructus Vitis viniferae 7%, Semen Sesami 40%, first meat 5%, Fructus Jujubae 2.5%, Radix Panacis Quinquefolii 0.5%, Fructus Schisandrae Chinensis 2%, Semen Coicis 12%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 6%, Radix Polygalae 4%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 5%, Fructus Momordicae 15%, Radix Rhodiolae 30%, Rhizoma Dioscoreae 4%, Radix Codonopsis 13%, Radix Notoginseng 28%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 5%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 3; All the other all with example together

The preparation of present embodiment is a soft capsule, and the weight ratio of each raw material of soft capsule is: the A powder: the B powder: C powder: water: Mel: gelatin=5: 0: 5: 6: 3: 8.

Embodiment eight:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 20%, Rhizoma Dioscoreae 60%, Radix Panacis Quinquefolii 10%, Semen Cuscutae 0%, Radix Pseudostellariae 10%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 4%, Radix Rhodiolae 5%, Lentinus Edodes 5%, Fructus Schisandrae Chinensis 5%, longan 2%, Semen Ziziphi Spinosae 2%, Folium Mori 6%, Flos Chrysanthemi 3%, Semen Cassiae 9%, Flos Lonicerae 7%, Rhizoma Phragmitis 6%, Pericarpium Citri Reticulatae 5%, Bulbus Lilii 5%, Poria 5%, Semen Coicis 15%, Fructus Jujubae 10%, Radix Glycyrrhizae 3%, Fructus Mori 1%, Fructus Crataegi 0%, the Radix Astragali 2%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 7%, circle meat 6%, Rhizoma Zingiberis 4%, Poria 8%, dried Fructus Vitis viniferae 6%, Semen Sesami 10%, first meat 35%, Fructus Jujubae 3%, Radix Panacis Quinquefolii 3%, Fructus Schisandrae Chinensis 3%, Semen Coicis 10%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 5%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 4%, Fructus Momordicae 4%, Radix Rhodiolae 20%, Rhizoma Dioscoreae 8%, Radix Codonopsis 4%, Radix Notoginseng-48%, Rhizoma Polygonati 4%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 0%, Bulbus Fritillariae Cirrhosae 0%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 8%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 9; All the other all with example together

The preparation of present embodiment is a tablet, and the weight ratio of each raw material of tablet is: the A powder: the B powder: the C powder: Fructrs Jujubae Powder=7: 6: 0: 6.

Embodiment nine:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 33%, Rhizoma Dioscoreae 50%, Radix Panacis Quinquefolii 13%, Semen Cuscutae 4%, Radix Pseudostellariae 0%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 4%, Radix Rhodiolae 5%, Lentinus Edodes 20%, Fructus Schisandrae Chinensis 6%, longan 2%, Semen Ziziphi Spinosae 1%, Folium Mori 5%, Flos Chrysanthemi 2%, Semen Cassiae 2%, Flos Lonicerae 3%, Rhizoma Phragmitis 6%, Pericarpium Citri Reticulatae 2%, Bulbus Lilii 25%, Poria 5%, Semen Coicis 6%, Fructus Jujubae 3%, Radix Glycyrrhizae 0%, Fructus Mori 3%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, circle meat 2%, Rhizoma Zingiberis 2%, Poria 5%, dried Fructus Vitis viniferae 25%, Semen Sesami 5%, first meat 5%, Fructus Jujubae 4%, Radix Panacis Quinquefolii 2%, Fructus Schisandrae Chinensis 4%, Semen Coicis 35%, Radix Polygoni Multiflori Preparata 0%, Semen Cuscutae 0%, Cortex Cinnamomi 0%, the Cortex Eucommiae 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Herba Taxilli 0%, Radix Polygalae 0%, Radix Glycyrrhizae 0%, Herba Epimedii 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 38%, Fructus Momordicae 20%, Radix Rhodiolae 5%, Rhizoma Dioscoreae 0.5%, Radix Codonopsis 0.5%, Radix Notoginseng 15%, Rhizoma Polygonati 2%, Radix Ophiopogonis 2%, the Rhizoma Pinelliae 2%, Bulbus Fritillariae Cirrhosae 2%, Fructus Ligustri Lucidi 3%, Herba Cynomorii 2%, Radix Salviae Miltiorrhizae 3%, Fructus Cannabis 2%, Placenta Hominis powder 3%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 7; All the other all with example together

The preparation of present embodiment is a tablet, and the weight ratio of each raw material of tablet is: the A powder: the B powder: the C powder: Fructrs Jujubae Powder=8: 0: 4: 5.

Embodiment ten:

This mixture of a kind of health care mixture of antifatigne and enhancing immunity is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%): Cortex Cinnamomi 18%, Rhizoma Dioscoreae 34%, Radix Panacis Quinquefolii 3%, Semen Cuscutae 5%, Radix Pseudostellariae 40%.

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%): Fructus Lycii 5%, Radix Rhodiolae 4%, Lentinus Edodes 5%, Fructus Schisandrae Chinensis 6%, longan 3%, Semen Ziziphi Spinosae 2%, Folium Mori 5%, Flos Chrysanthemi 2%, Semen Cassiae 2%, Flos Lonicerae 2%, Rhizoma Phragmitis 5%, Pericarpium Citri Reticulatae 1%, Bulbus Lilii 6%, Poria 6%, Semen Coicis 40%, Fructus Jujubae 2%, Radix Glycyrrhizae 2%, Fructus Mori 2%, Fructus Crataegi 0%, the Radix Astragali 0%, Radix Angelicae Sinensis 0%, Radix Codonopsis 0%, Herba Epimedii 0%, the Cortex Eucommiae 0%.

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%): mentha leave 1.5%, Fructus Momordicae 1.5%, Radix Rhodiolae 6%, Rhizoma Dioscoreae 3%, Radix Codonopsis 3%, Radix Notoginseng 20%, Rhizoma Polygonati 0%, Radix Ophiopogonis 0%, the Rhizoma Pinelliae 28%, Bulbus Fritillariae Cirrhosae 37%, Fructus Ligustri Lucidi 0%, Herba Cynomorii 0%, Radix Salviae Miltiorrhizae 0%, Fructus Cannabis 0%, Placenta Hominis powder 0%.

Its preparation method removes the CO of mixture I and mixtures II ₂The weight ratio of supercritical extract is outside 1: 6.5; All the other all with example together

The preparation of present embodiment is a capsule, and the weight ratio of capsular each raw material is: the A powder: the B powder: the C powder: Fructrs Jujubae Powder=6: 9: 5: 3.

Claims (5)

1, a kind of health care mixture of antifatigne and enhancing immunity is characterized in that this mixture is by the health product that have physical absorption and slow-release function mixture I, antifatigne and enhancing immunity functional mixture II, assist a ruler in governing a country gentle functional mixture III, balance and conditioning functions mixture IV four part material mixture are made any dosage form by known health product technology; Wherein:

Having physical absorption and slow-release function mixture I is made by the raw material of following weight percent (in 100%):

Cortex Cinnamomi 10～38% Rhizoma Dioscoreaes 10～70% Radix Panacis Quinquefoliis 1～20% Semen Cuscutae 0～60%

Radix Pseudostellariae 0～60%;

Antifatigne and enhancing immunity functional mixture II is made by the raw material of following weight percent (in 100%):

Fructus Lycii 4～40% Radix Rhodiolaes 4～20% Lentinus Edodess 5～50% Fructus Schisandrae Chinensis 5～50%

Longan 2～20% Semen Ziziphi Spinosaes 1～30% Folium Mori 5～50% Flos Chrysanthemis 2～15% Semen Cassiaes 2～40%

Flos Lonicerae 2～15% Rhizoma Phragmitiss 5～20% Pericarpium Citri Reticulataes 1～40% Bulbus Lilii 5～40% Poria 5～50%

Semen Coicis 5～50% Fructus Jujubaes 2～20% Radix Glycyrrhizaes 0～15% Fructus Mori 1～25% Fructus Crataegi 0～50%

The Radix Astragali 0～30% Radix Angelicae Sinensis 0～30% Radix Codonopsis 0～20% Herba Epimedii 0～50% Cortex Eucommiae 0～40;

Assisting a ruler in governing a country gentle functional mixture III is to be made by the raw material of following weight percent (in 100%):

Fructus Lycii 5～40% circle meat 2～36% Rhizoma Zingiberiss 1～20% Poria 5～30% dried Fructus Vitis viniferae 4～30%

5～50% yuan of meat of Semen Sesami, 5～40% Fructus Jujubaes, 2～60% Radix Panacis Quinquefoliis 0.5～40%

Fructus Schisandrae Chinensis 2～60% Semen Coiciss 1040% Radix Polygoni Multiflori Preparata 0～40% Semen Cuscutae 0～40%

Cortex Cinnamomi 0～60% Cortex Eucommiae 0～60% Radix Astragali 0～60% Radix Angelicae Sinensis 0～60% Herba Taxilli 0～60%

Radix Polygalae 0～60% Radix Glycyrrhizae 0～60% Herba Epimedii 0～60%

Balance and conditioning functions mixture IV are made by the raw material of following weight percent (in 100%):

Mentha leave 1.2～60% Fructus Momordicaes 1.2～50% Radix Rhodiolaes 5～50% Rhizoma Dioscoreaes 0.5～20%

Radix Codonopsis 0.5～20% Radix Notoginseng 0.5～50% Rhizoma Polygonati Rhizoma Pinelliae 0～30% 0～20% Radix Ophiopogonis 0～20%

Bulbus Fritillariae Cirrhosae 0～60% Fructus Ligustri Lucidi 0～60% Herba Cynomorii 0～60% Radix Salviae Miltiorrhizae 0～60% Fructus Cannabis 0～50%

Placenta Hominis powder 0-15%

Said mixture thing I is pulverized the CO of back and mixtures II ₂Supercritical extract is by weight 1: (2-10) the mixed A powder that gets; To make B powder and C powder behind mixtures III and the mixture IV pulverize separately; With A powder, B powder, C powder by weight (0.5～8): (0～10): (0～6) is mixed and is got final product.

2, the health care mixture of antifatigne and enhancing immunity as claimed in claim 1 is characterized in that the dosage form of described health care mixture can be oral liquid, capsule, pill, tablet, electuary.

3, the health care mixture of antifatigne and enhancing immunity as claimed in claim 1 or 2, it is characterized in that when health care mixture is oral liquid or soft capsule the weight ratio of A powder, B powder, C powder and water, Mel, gelatin is (0.5-8): (0-10): (0-6): (1-20): (0.5-8): (0～15).

4, the health care mixture of antifatigne and enhancing immunity as claimed in claim 1 or 2 is characterized in that when health care mixture is tablet or capsule the weight ratio of A powder, B powder, C powder and Fructrs Jujubae Powder is (0.5-8): (0-10): (0-6): (1-8).

5, the preparation technology of the health care mixture of antifatigne and enhancing immunity as claimed in claim 1 is characterized in that mixture I, III, IV after washing, 80-140 ℃ of following drying and crushing to the 150-200 order; With mixtures II washing, 80-140 ℃ of oven dry down, pulverize to put into and extract still, at pressure 10-25Mpa, temperature 4-55 ℃, time 45-120 minute, entrainer 95% ethanol, high-pressure pump adds CO ₂, utilize CO ₂Supercritical extraction is carried 3-4 time; Under 4-45 ℃, water is carried 30-120 minute again, repeats water and carries 3-5 time, the centrifugal decontamination of extracting solution is sneaked into mixture I mixes thoroughly, spray drying becomes the A powder.