CN104352646A - Medicine composition for relieving physical fatigue and strengthening immunity and preparation method thereof - Google Patents
Medicine composition for relieving physical fatigue and strengthening immunity and preparation method thereof Download PDFInfo
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a traditional Chinese medicine compound preparation, and discloses a medicine composition for relieving physical fatigue and strengthening immunity. The medicine composition comprises the following components and contents in parts by weight: 1.5-2.5 parts of cinnamon, 3-5 parts of radix polygalae, 3-5 parts of black ants, 3-5 parts of semen cuscutae and 3-5 parts of Chinese wolfberry. The five medicines have synergistic effects to achieve the following effects that the health-care functions of nourishing yin, tonifying yang, strengthening and consolidating body resistance, relieving physical fatigue and strengthening immunity are obvious, the safety is high, and toxic and side effects are small. The invention also relates to a preparation method for the medicine composition for relieving the physical fatigue and strengthening the immunity. The preparation method disclosed by the invention has the advantages of simple operation, environment protection, high economy, high efficiency, no toxicity and wide application prospects.
Description
Technical field
The present invention relates to Chinese medicine compound and control agent, relate to a kind of pharmaceutical composition with alleviating physical fatigue and enhancing immunity, particularly relate to the preparation method of the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Background technology
Along with growth in the living standard, people are no longer confined to the passive mode of ill treatment to the requirement of health, more bias toward non-disease namely to prevent, diseases prevention is in possible trouble, in view of society this in the urgent need to, a kind of existing prevention is provided, health-care effect can be cured the disease again both have concurrently powerful enhancing immunity, improve resistance external powder necessary.
And the pressure of present social people all grows with each passing day, also immediately, people more and more focus on the immunity strengthening self to sub-health status.And the health product of existing a lot of enhancing immunity, be much the dangerous of industry manufacture, also there is toxic and side effects.
Summary of the invention
The present invention is directed to existing in shortcoming, disclose a kind of pharmaceutical composition with alleviating physical fatigue and enhancing immunity, also disclose the preparation method of the pharmaceutical composition with alleviating physical fatigue and enhancing immunity; Easy to prepare, condition is simple, safe and reliable, be applicable to suitability for industrialized production.
In order to solve the problems of the technologies described above, the present invention is solved by following technical proposals.
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, in following weight proportion, each component and content is, 1.5-2.5 part Cortex Cinnamomi, 3-5 part Radix Polygalae, 3-5 part Formica fusca, 3-5 part Semen Cuscutae, 3-5 part Fructus Lycii.The pharmaceutical composition with alleviating physical fatigue and enhancing immunity that the raw material of this proportioning is made, safety is high, has nourishing YIN and invigorating YANG, strengthening the body resistance, and the health care of alleviating physical fatigue and enhancing immunity is obvious.The drug effect of selected medical material is as follows:
Cortex Cinnamomi, pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that function mends fire, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.
Radix Polygalae, bitter, pungent, temperature.GUIXIN, kidney, lung meridian.Function is calmed the nerves Fructus Alpiniae Oxyphyllae, and restoring normal coordination between the heart and kidney, eliminates the phlegm, detumescence.
Formica fusca, salty, sour, flat, enter liver, kidney channel.Function cold expelling gas, consumer edema, reinforcing the heart brain is supporing yang by force.
Semen Cuscutae, pungent, sweet, flat, enter liver,kidney,spleen warp.Function liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal; External pathogenic wind expelling speckle dispelling.
Fructus Lycii, sweet, flat, enter liver, kidney channel.Function tonification Liver and kidney, replenishing vital essence to improve eyesight.
As preferably, in following weight proportion, each component and content is, 1.5-2.5 part Cortex Cinnamomi, 3-4.2 part Radix Polygalae, 3-4.2 part Formica fusca, 3-4.2 part Semen Cuscutae, 3-4.2 part Fructus Lycii.The pharmaceutical composition with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity of the raw material formation of this proportioning, safety is high, and the effect of alleviating physical fatigue and enhancing immunity is ideal.
As preferably, in following weight proportion, each component and content is, 2 portions of Cortex Cinnamomis, 4 parts of Radix Polygalaes, 4 parts of Formica fuscas, 4 parts of Semen Cuscutae, 4 parts of Fructus Lycii.The pharmaceutical composition with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity of the raw material formation of this proportioning, safety is high, and the effect of alleviating physical fatigue and enhancing immunity is ideal.
As preferably, the pharmaceutical composition with alleviating physical fatigue and enhancing immunity of every 18 grams comprises following component: 2g Cortex Cinnamomi, 4g Radix Polygalae, 4g Formica fusca, 4g Semen Cuscutae, 4g Fructus Lycii.The pharmaceutical composition with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity of the raw material formation of this proportioning, safety is high, the best results of alleviating physical fatigue and enhancing immunity.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes oral liquid or tablet or capsule or pill or granule or drop pill.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5-8 milliliter, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5-8 milliliter, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.30, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 7-10 ml water, decoct twice, and first time decocts 1.5-3h, and second time decocts 1-2h; Every 1 gram of all the other four Chinese medicine material adds 7-10 ml water, and the effect that during decoction, Chinese medicine ingredients is dissolved in water is better.When decocting twice, more desirable to the effect of Chinese medicine constituents extraction.
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.05-1.15, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.Chinese medicine water drug-decocting concentrating liquid, removes the starch, protein etc. of non-prolamine, adds the liquid that ethanol is made into certain alcoholic degree, then room temperature preferably freezing sedimentation carry out solid-liquid separation to improve alcoholic degree and the clarity of Chinese medicine extraction liquid, thus to improve the quality of products.
As preferably, step D, adds starch, mixes, incapsulate with the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Compared with prior art, beneficial effect of the present invention is:
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity that the present invention is Cortex Cinnamomi, Radix Polygalae, Formica fusca, Semen Cuscutae, Fructus Lycii obtain.Find through clinical trial, 5 taste synergism, have following effect: have nourishing YIN and invigorating YANG, strengthening the body resistance, and the health care of alleviating physical fatigue and enhancing immunity is obvious.And safety of the present invention is high, toxic and side effects is little.
Preparation method of the present invention, simple to operate, environmental protection, economy, efficient, nontoxic, have broad application prospects.
Detailed description of the invention
Embodiment 1
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, in following weight proportion, each component and content is, 1.5 portions of Cortex Cinnamomis, 3 parts of Radix Polygalaes, 3 parts of Formica fuscas, 3 parts of Semen Cuscutae, 3 parts of Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes oral liquid.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 7 ml waters, decoct twice, and first time decocts 1.5h, and second time decocts 1h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.05-1.15, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Embodiment 2
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, in following weight proportion, each component and content is, 2.5 portions of Cortex Cinnamomis, 5 parts of Radix Polygalaes, 5 parts of Formica fuscas, 5 parts of Semen Cuscutae, 5 parts of Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes tablet.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 8 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 8 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.30, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 10 ml waters, decoct twice, and first time decocts 3h, and second time decocts 2h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.15, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Embodiment 3
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, in following weight proportion, each component and content is, 2.5 portions of Cortex Cinnamomis, 4.2 parts of Radix Polygalaes, 4.2 parts of Formica fuscas, 4.2 parts of Semen Cuscutae, 4.2 parts of Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes capsule.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.28, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 8 ml waters, decoct twice, and first time decocts 2.5h, and second time decocts 1.5h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.09, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
D. add starch, mix with the pharmaceutical composition with alleviating physical fatigue and enhancing immunity, incapsulate.
Embodiment 4
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, in following weight proportion, each component and content is, 2 portions of Cortex Cinnamomis, 4 parts of Radix Polygalaes, 4 parts of Formica fuscas, 4 parts of Semen Cuscutae, 4 parts of Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes pill.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate; Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.21, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 8 ml waters, decoct twice, and first time decocts 1.6, and second time decocts 1.2h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.06, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Embodiment 5
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, the pharmaceutical composition of every 18 grams comprises following component: 2g Cortex Cinnamomi, 4g Radix Polygalae, 4g Formica fusca, 4g Semen Cuscutae, 4g Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes granule.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.29, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 8 ml waters, decoct twice, and first time decocts 2.9h, and second time decocts 1.9h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.14, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Embodiment 6
Have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, the pharmaceutical composition of every 18 grams comprises following component: 2g Cortex Cinnamomi, 4g Radix Polygalae, 4g Formica fusca, 4g Semen Cuscutae, 4g Fructus Lycii.
The pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes drop pill.
The above-described preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity, comprises the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5.5 milliliters, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.28, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 8 ml waters, decoct twice, and first time decocts 2.5h, and second time decocts 1.5h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.09, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
Embodiment 7
This experiment, by the research with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity prepared embodiment 6, understands the effect of its alleviating physical fatigue and enhancing immunity.
One, experiment material
1.1 medicine
Test sample: the pharmaceutical composition with alleviating physical fatigue and enhancing immunity prepared by embodiment 6.
Positive drug: Ginseng Injection (specification: 2ml/ props up, every ml is equivalent to 5g crude drug); Levamisole hydrochloride tablets (25mg/ sheet); Hydrocortisone (specification: 2ml:10mg); India ink (specification: 50ml/ bottle).
1.2 animals: Kunming mouse, cleaning grade animal, Experimental Animal Center provides.
1.3 instruments: tintometer.
Two, method and result
2.1 impacts on mouse anti-reflecting fatigue function
Choose 18 ~ 22g healthy mice 100, male and female half and half.Be divided into 5 groups at random, be respectively blank group, Ginseng Injection group (injection 3.0g/kg lumbar injection Ginseng Injection), all the other three components do not gavage the pharmaceutical composition with alleviating physical fatigue and enhancing immunity prepared by 10.0g/kg, 5.0g/kg, 2.5g/kg embodiment 6,1 times/day, continuous 10 days.After last administration 45min, Mus tail hangs the weight that a load is this Mus body weight 5%, mice is put into special water tank [water temperature (25.0 ± 0.5) DEG C, depth of water 30cm] went swimming.Observed and recorded mice is water floating time (namely mice is placed in water and is immersed in the water to head the time that 10s can not emerge completely, the results are shown in Table 1).
The drug regimen extract of table 1 alleviating physical fatigue and enhancing immunity is on the impact of mouse anti-reflecting fatigue function
Note: with blank group ratio
*p<0.01,
*p<0.05
Result shows, and middle dosage group, high dose group can significantly improve mice swimming time, show that the pharmaceutical composition with alleviating physical fatigue and enhancing immunity of 6 preparations has antifatigue effect.
2.2 impacts on mice reticuloendothelial system (RES) phagocytic function
Choose body weight 18 ~ 22g mice 60, male and female half and half, be divided into 6 groups at random, by table 2 successive administration 10 days, 1 times/day.Except blank group, every Mus is lumbar injection hydrocortisone 60mg/kg every other day, last administration 45min, tail vein injection 1:4 india ink (0.1ml/10g).Injection after 1min (t1) and 5min (t2) respectively from each rathole crash get blood 20 μ L, be dissolved in 2ml 0.1%NaCO 3 solution, by tintometer colorimetric determination optical density (OD), by following formulae discovery phagocytic index, the results are shown in Table 2.
Phagocytic index K=(1ogOD
1-logOD
2)/(t2-t1), optical density when wherein OD1, OD2 are respectively 1min and 5min, t1=1, t2=5.
The drug regimen extract of table 2 alleviating physical fatigue and enhancing immunity is on the impact of mice (RES) phagocytic function
| Grouping | Dosage (g/kg) | Number of animals | Phagocytic index |
| Blank group | / | 10 | 0.074±0.023 ＊ |
| Model control group | / | 10 | 0.039±0.019 |
| Levamisole hydrochloride | 0.06 | 10 | 0.078±0.021 ＊＊ |
| Low dose group | 2.5 | 10 | 0.062±0.020 ＊ |
| Middle dosage group | 5.0 | 10 | 0.061±0.028 ＊ |
| High dose group | 10.0 | 10 | 0.062±0.020 ＊ |
Note: with model control group ratio
*p<0.01,
*p<0.05.
Result shows, middle dosage group, high dose group have obvious facilitation to mice RES phagocytic function, and low dose group also has certain promotion, shows that the pharmaceutical composition with alleviating physical fatigue and enhancing immunity of 6 preparations has nonspecific immunity promotion functions.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (7)
1. have a pharmaceutical composition for alleviating physical fatigue and enhancing immunity, it is characterized in that: in following weight proportion, each component and content is, 1.5-2.5 part Cortex Cinnamomi, 3-5 part Radix Polygalae, 3-5 part Formica fusca, 3-5 part Semen Cuscutae, 3-5 part Fructus Lycii.
2. the pharmaceutical composition with alleviating physical fatigue and enhancing immunity according to claim 1, it is characterized in that: in following weight proportion, each component and content is, 1.5-2.5 part Cortex Cinnamomi, 3-4.2 part Radix Polygalae, 3-4.2 part Formica fusca, 3-4.2 part Semen Cuscutae, 3-4.2 part Fructus Lycii.
3. the pharmaceutical composition with alleviating physical fatigue and enhancing immunity according to claim 1, is characterized in that: in following weight proportion, and each component and content is, 2 portions of Cortex Cinnamomis, 4 parts of Radix Polygalaes, 4 parts of Formica fuscas, 4 parts of Semen Cuscutae, 4 parts of Fructus Lycii.
4. the pharmaceutical composition with alleviating physical fatigue and enhancing immunity according to claim 1, is characterized in that: the pharmaceutical composition with alleviating physical fatigue and enhancing immunity of every 18 grams comprises following component: 2g Cortex Cinnamomi, 4g Radix Polygalae, 4g Formica fusca, 4g Semen Cuscutae, 4g Fructus Lycii.
5. the pharmaceutical composition with alleviating physical fatigue and enhancing immunity according to claim 1 or 2 or 3 or 4, is characterized in that: the pharmaceutical composition with alleviating physical fatigue and enhancing immunity makes oral liquid or tablet or capsule or pill or granule or drop pill.
6. claim 1 or the preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity described in 2 or 3 or 4, is characterized in that: comprise the following steps,
A. get the ethanol that Formica fusca adds 75%, every 1 gram of Formica fusca adds the ethanol of 5-8 milliliter, 70 DEG C of backflows 2.0 hours, filters and obtains the first filtrate;
Filter the ethanol that the Formica fusca obtained adds 75% again, every 1 gram of Formica fusca adds the ethanol of 5-8 milliliter, 70 DEG C of backflows 2.0 hours, filters and obtains the second filtrate;
Merge the first filtrate, the second filtrate, at 65 DEG C, filtrate is concentrated into the clear paste that relative density is 1.25-1.30, it is for subsequent use to dry, pulverize into fine powder;
B. all the other four Chinese medicine materials decoct with water, and every 1 gram of all the other four Chinese medicine material adds 7-10 ml water, decoct twice, and first time decocts 1.5-3h, and second time decocts 1-2h;
C. merge twice decoction and filter the filtrate obtained afterwards, at 65 DEG C, filtrate is concentrated into the extractum that relative density is 1.05-1.15, after drying, extractum is mixed with segmentation, obtain the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
7. the preparation method with the pharmaceutical composition of alleviating physical fatigue and enhancing immunity according to claim 6, is characterized in that: step D, adds starch, mixes, incapsulate with the pharmaceutical composition with alleviating physical fatigue and enhancing immunity.
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| CN104352646B CN104352646B (en) | 2018-09-21 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105213625A (en) * | 2015-08-19 | 2016-01-06 | 同溢堂药业有限公司 | Pharmaceutical composition of a kind of alleviating physical fatigue and preparation method thereof |
| CN106138440A (en) * | 2016-08-30 | 2016-11-23 | 张丽 | A kind of containing Lepidinm meyenii Walp and the compositions of Radix Rhodiolae and preparation method and purposes |
| CN107772433A (en) * | 2016-08-31 | 2018-03-09 | 江苏康缘药业股份有限公司 | One kind, which has, alleviates physical fatigue, strengthen immunity composition and preparation method thereof |
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| CN1426787A (en) * | 2001-12-20 | 2003-07-02 | 肖永良 | Health care mixture for antifatigne and enhancing immunity |
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| CN1426787A (en) * | 2001-12-20 | 2003-07-02 | 肖永良 | Health care mixture for antifatigne and enhancing immunity |
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| 钱丽丽，等。: ""试论中医缓解体力疲劳保健食品的特色"", 《山西中医》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213625A (en) * | 2015-08-19 | 2016-01-06 | 同溢堂药业有限公司 | Pharmaceutical composition of a kind of alleviating physical fatigue and preparation method thereof |
| CN106138440A (en) * | 2016-08-30 | 2016-11-23 | 张丽 | A kind of containing Lepidinm meyenii Walp and the compositions of Radix Rhodiolae and preparation method and purposes |
| CN106138440B (en) * | 2016-08-30 | 2019-08-06 | 张丽 | A kind of composition containing maca and root of kirilow rhodiola and preparation method and purposes |
| CN107772433A (en) * | 2016-08-31 | 2018-03-09 | 江苏康缘药业股份有限公司 | One kind, which has, alleviates physical fatigue, strengthen immunity composition and preparation method thereof |
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| CN104352646B (en) | 2018-09-21 |
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