CN104435749A - Dendrobium officinale compound preparation as well as preparation method and application of dendrobium officinale compound preparation - Google Patents
Dendrobium officinale compound preparation as well as preparation method and application of dendrobium officinale compound preparation Download PDFInfo
- Publication number
- CN104435749A CN104435749A CN201410632144.9A CN201410632144A CN104435749A CN 104435749 A CN104435749 A CN 104435749A CN 201410632144 A CN201410632144 A CN 201410632144A CN 104435749 A CN104435749 A CN 104435749A
- Authority
- CN
- China
- Prior art keywords
- herba dendrobii
- compound preparation
- preparation
- radix panacis
- panacis quinquefolii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 66
- 150000001875 compounds Chemical class 0.000 title claims abstract description 61
- 241001076416 Dendrobium tosaense Species 0.000 title abstract description 18
- 238000000605 extraction Methods 0.000 claims abstract description 32
- 241000222336 Ganoderma Species 0.000 claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 27
- 230000036039 immunity Effects 0.000 claims abstract description 18
- 230000002708 enhancing effect Effects 0.000 claims abstract description 12
- 230000036541 health Effects 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 49
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 16
- 239000002893 slag Substances 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 13
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 13
- 238000010438 heat treatment Methods 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 13
- 210000003734 kidney Anatomy 0.000 abstract description 11
- 230000006870 function Effects 0.000 abstract description 9
- 239000000463 material Substances 0.000 abstract description 8
- 210000001124 body fluid Anatomy 0.000 abstract description 7
- 239000010839 body fluid Substances 0.000 abstract description 7
- 210000004185 liver Anatomy 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 244000241838 Lycium barbarum Species 0.000 abstract description 3
- 235000015459 Lycium barbarum Nutrition 0.000 abstract description 3
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000002791 Panax Nutrition 0.000 abstract 2
- 241000208343 Panax Species 0.000 abstract 2
- 230000001914 calming effect Effects 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 22
- 239000008187 granular material Substances 0.000 description 21
- 230000007812 deficiency Effects 0.000 description 15
- 239000000284 extract Substances 0.000 description 14
- 206010016256 fatigue Diseases 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 11
- 229960000890 hydrocortisone Drugs 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 210000000265 leukocyte Anatomy 0.000 description 7
- 238000010172 mouse model Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000000242 pagocytic effect Effects 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 210000001541 thymus gland Anatomy 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 239000004375 Dextrin Substances 0.000 description 5
- 229920001353 Dextrin Polymers 0.000 description 5
- 241001494479 Pecora Species 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 235000019425 dextrin Nutrition 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 240000005373 Panax quinquefolius Species 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 230000036737 immune function Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 206010010144 Completed suicide Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000003172 expectorant agent Substances 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000003014 reinforcing effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- 241000190633 Cordyceps Species 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 241001523681 Dendrobium Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000013016 learning Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 210000004279 orbit Anatomy 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000004377 improving vision Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a dendrobium officinale compound preparation as well as a preparation method and application of the dendrobium officinale compound preparation. The dendrobium officinale compound preparation is prepared from the following raw materials in percentage by weight: 15-30% of dendrobium officinale, 10-20% of wolfberry, 10-30% of panax quinguefolium, 10-20% of lucid ganoderma and 5-35% of auxiliary materials. According to the dendrobium officinale compound preparation, the dendrobium officinale has the effects of nourishing yin and promoting the secretion of saliva or body fluid, the panax quinguefolium has the effects of tonifying qi and nourishing yin, the lucid ganoderma has the effects of tonifying qi and calming the nerves, the wolfberry has the effects of nourishing the liver and kidneys, and if all the components are combined to use, a synergistic effect can be generated, and the health functions of enhancing the immunity and relieving the physical fatigue can be achieved. The dendrobium officinale compound preparation disclosed by the invention can be applied to preparation of health products and drugs for enhancing the immunity and relieving the physical fatigue. The preparation method of the dendrobium officinale compound preparation, disclosed by the invention, is simple in extraction process, good in functional component extracting effect and wide in application prospect and is easily used for industrial production.
Description
Technical field
The present invention relates to Herba Dendrobii compound medicine field, be specifically related to a kind of Herba Dendrobii compound preparation and its preparation method and application.
Background technology
In recent years, along with development and the growth in the living standard of science and technology, the average life of compatriots constantly extends, aging is stepped into gradually in many cities, in order to improve the quality of living, strengthen life effect, the health product of reasonable employment illness prevention and fitness oneself become the conscious requirement of one of people gradually, the research and development in this field also more and more comes into one's own.
Application publication number is that the Chinese invention patent application of CN 102988827A (application number is CN 201210473859.5) discloses a kind of dendrobium officinale granula, primarily of compositions such as Herba Dendrobii, Poria, Radix Ginseng, Fructus Lycii, Rhizoma Dioscoreae, Semen Coiciss, the weight proportion of described Herba Dendrobii, Poria, Radix Ginseng, Fructus Lycii, Rhizoma Dioscoreae, Semen Coicis is: 15 ~ 28:30 ~ 42:7 ~ 18:3 ~ 13:15 ~ 28:15 ~ 28.This technical scheme is composite by each medicine, can immunity moderation function, resisting fatigue, boosting qi and nourishing yin, be applicable to system weakness and fatiguability person, particularly to rehabilitation after being ill, overwork, lung-stomach yin deficiency shower has good effect, the spiritlessness and weakness of people caused by busy working and learning can be eliminated, can effectively improve working and learning efficiency.
Application publication number is that the Chinese invention patent application of CN 102349975A (application number is CN 201110306954.1) discloses a kind of Dendrobium officinale health product formula, the preparation method of compositions and combination and purposes, this formula comprises monarch drug, ministerial drug and adjuvant drug, monarch drug is Herba Dendrobii and Cordyceps powder, ministerial drug is Radix Panacis Quinquefolii, adjuvant drug is Fructus Lycii, and its content is: fresh Herba Dendrobii 50 ~ 1000g, Cordyceps powder 3 ~ 9g, Radix Panacis Quinquefolii 3 ~ 6g, Fructus Lycii 6 ~ 12g.This Dendrobium officinale health product formula, no matter from Chinese medicine aspect or pharmacology aspect, at least has effect of enhancing immunity.
Application publication number is that the Chinese invention patent application of CN 1457808A (application number is 02111657.1) discloses a kind of Herba Dendrobii compound preparation and Synthesis and applications thereof, said preparation is the oral formulations that forms of 20% ~ 80% active component and 80% ~ 20% pharmaceutic adjuvant or beverage by percentage by weight, wherein, active ingredient is made up of percentage by weight 5% ~ 50% Herba Dendrobii, 5 ~ 50% Herba Dendrobii extractum, 5 ~ 50% Radix Panacis Quinquefoliis or Radix Panacis Quinquefolii extractum.Its preparation method comprises: Herba Dendrobii is picked decontamination by (1), and 70% ethanol sterilizing, waves most ethanol, more than superfine grinding 300 order for subsequent use after dry; (2) Herba Dendrobii water heating and refluxing extraction, merge extractive liquid, concentrated final vacuum is dry, obtains extract powder for subsequent use; (3) Radix Panacis Quinquefolii 70% alcohol heating reflux extracts, merge extractive liquid, and concentrated final vacuum is dry, obtains extract powder for subsequent use; (4) take dendrobium officinale powder, Herba Dendrobii extract powder and American ginseng extract powder by recipe quantity, add conventional adjuvant, fully mix according to a conventional method, make granule, obtain granule; Granule is inserted in capsulae vacuus, obtain capsule; Granule is directly pressed into sheet, obtains tablet; Slice, thin piece film coating, obtains thin membrane coated tablet.This Herba Dendrobii compound preparation can immunity moderation function and resisting fatigue, boosting qi and nourishing yin, is applicable to the weak and fatiguability person of system, particularly to rehabilitation after being ill, overwork, lung-stomach yin deficiency shower has good effect.
Summary of the invention
The object of this invention is to provide a kind of Herba Dendrobii compound preparation and its preparation method and application, this Herba Dendrobii compound preparation has enhancing immunity, the health care of alleviating physical fatigue.
A kind of Herba Dendrobii compound preparation, be made up of the raw material of following percentage by weight:
As preferably, described Herba Dendrobii compound preparation, be made up of the raw material of following percentage by weight:
Further preferably, in described Herba Dendrobii compound preparation, the mass ratio of described Herba Dendrobii, Fructus Lycii, Radix Panacis Quinquefolii and Ganoderma is 3:2:3:2.Under this mass ratio, above-mentioned functional component synergism is stronger.
In the present invention, Herba Dendrobii Yin-nourishing and body fluid promoting, joins Radix Panacis Quinquefolii boosting qi and nourishing yin, joins Ganoderma invigorating QI and tranquilization, joins Fructus Lycii nourishing the liver and kidney, closes and uses it.Herba Dendrobii, Fructus Lycii, Radix Panacis Quinquefolii to become with Ganoderma four kinds deciliter and with can produce synergism.Both be suitable for the body of vital essence deficiency, be suitable for again the people of YIN fluid deficiency, for deficiency of both the lung and kidney, deficiency of both vital energy and Yin, fatigue and weakness, lumbocrural pain, the few expectorant of cough, dry mouth and throat, deficient pulse weak person.In the health product that Herba Dendrobii compound preparation of the present invention can be used for preparing enhancing immunity and alleviating physical fatigue and medicine.
In raw material contained by compound dendrobium officinale preparation prescription, effective ingredient is not quite similar, contained by Herba Dendrobii, the functional component of enhancing immunity, resisting fatigue is mainly dendrobium polysaccharide, the functional component of Ganoderma is ganoderan, the functional component of Fructus Lycii is Lycium barbarum polysaccharides, therefore these three kinds of raw materials adopt water as solvent extraction, and the functional component of Radix Panacis Quinquefolii is except water soluble polysaccharide, American ginseng total saponins is also had to be liposoluble constituent, therefore water extraction again after first adopting ethanol water (most preferably 70%) to extract.
A preparation method for Herba Dendrobii compound preparation, comprises the following steps:
(1) Herba Dendrobii is broken into powder, obtains powdery Herba Dendrobii;
(2) Radix Panacis Quinquefolii is broken into powder, adds the ethanol water heating and refluxing extraction that mass fraction is 60% ~ 80%, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, extracting solution, through concentrating under reduced pressure, obtains Radix Panacis Quinquefolii extractum;
(3) the Radix Panacis Quinquefolii alcohol extraction slag in step (2), the powdery Herba Dendrobii in step (1), Fructus Lycii and Ganoderma are decocted with water, obtain decocting liquid, decocting liquid obtains filtrate after filtering, and filtrate, through concentrating under reduced pressure, obtains the water extracted immersing paste;
(4) the water extracted immersing paste that Radix Panacis Quinquefolii extractum step (2) obtained and step (3) obtain merges mixing, spray-driedly obtains pharmaceutically active powder;
(5) add adjuvant by the pharmaceutically active powder obtained in step (4), prepare Herba Dendrobii compound preparation.
In step (1), Herba Dendrobii is broken into powder, crosses 30 mesh sieves, obtain powdery Herba Dendrobii.Powdery Herba Dendrobii below this size is applicable to the extraction of effective ingredient.
In step (2), Radix Panacis Quinquefolii is broken into powder, after crossing 30 mesh sieves, adds the ethanol water heating and refluxing extraction that mass fraction is 60% ~ 80%.The Radix Panacis Quinquefolii powder of appropriate particle size is conducive to the extraction of American ginseng total saponins liposoluble constituent.
The mass fraction of described ethanol water is 70%, and mass fraction 70% ethanol water is very beneficial for the extraction of American ginseng total saponins liposoluble constituent, is fully extracted by active constituents of medicine.
Radix Panacis Quinquefolii in powdery and the weight ratio of ethanol water are 1:10 ~ 20, are conducive to active constituents of medicine to extract.
Described heating and refluxing extraction is 2 ~ 3 times, each 2 ~ 4 hours, merge extractive liquid.
Described extracting solution is 65 DEG C ~ 75 DEG C through the temperature of concentrating under reduced pressure.
In step (3), described Radix Panacis Quinquefolii alcohol extraction slag, powdery Herba Dendrobii, Fructus Lycii and the gross weight of Ganoderma and the weight ratio of water are 1:25 ~ 35, and this weight ratio is also conducive to the abundant extraction of effective ingredient.
Described filtrate is 70 DEG C ~ 80 DEG C through the temperature of concentrating under reduced pressure.
Described decocting with water obtains decocting liquid and is: decoct with water 2 ~ 3 times successively, each 3 ~ 5 hours, collecting decoction afterwards.
In step (5), described adjuvant is one or more (comprising two kinds) in the adjuvants such as lactose, sucrose, glucose, starch, dextrin, microcrystalline Cellulose, magnesium stearate, Mel, Pulvis Talci, xylitol, mannitol, maltose alcohol, Sorbitol, and processing is prepared into the preparations such as tablet, capsule, granule, pill, powder, oral liquid, medicated wine or unguentum.Wherein, the preparation of tablet, capsule, pill, granule, powder: the pharmaceutically active powder getting step (4) obtained is mixed homogeneously with proper auxiliary materials, obtained according to corresponding dosage form common process processing.The preparation of oral liquid, medicated wine, unguentum: get the obtained pharmaceutically active powder of step (4) conveniently technique to add water or ethanol dissolves, add suitable adjuvant mix homogeneously, obtained by corresponding dosage form common process processing.
In the crude drug of compound dendrobium officinale preparation of the present invention, the stem of Herba Dendrobii system orchid Herba Dendrobii, its medicinal beginning is loaded in Shennong's Herbal, and is listed in top grade.Motherland's medical science is thought and Herba Dendrobii slightly sweet flavor, micro-salty, cold in nature is entered stomach, kidney channel, nontoxic, has effect of the stomach reinforcing that promotes the production of body fluid, clearing away heat and nourishing YIN.Be applicable to calentura later stage cloudy Tianjin consumption wound and deficiency-heat is not moved back, irritated thirster.Can treating the liver deficiency of the kidney yin, be the key medicine of replenishing YIN and removing heat, reinforcing stomach reg fluid.Li Shizhen (1518-1593 A.D.) claims it to have the siddhi special effect of " reinforcing YIN-essence benefit is smart, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue meat, and sedate, except frightened, made light of one's life by commiting suicide and prolonged life " in Compendium of Material Medica.
Successive dynasties peculiar effect of medicine and pharmacology works Herba Dendrobii has clear and definite record, thinks that it is the superfine product of YIN nourishing tonify deficiency.Modern medicine and pharmacology research proves active component dendrobium polysaccharide contained in Herba Dendrobii, has immune dual regulation, to immunocompromised person, resists the invasion and attack of disease by immunity moderation systemic-function; To immunologic function hyperthyroid, by immunity moderation systemic-function, recover its normal level.Radix Panacis Quinquefolii sweet and slightly bitter taste, cool in nature, enter cardiopulmonary kidney three warp, lung benefiting is cloudy, clear asthenic fire, promoting the production of body fluid to quench thirst, and supplementary Amplifications of the Compendium of Materia Medica calls it, and " relieving restlessness is tired for tonifying the lung pathogenic fire reducing, born fluid, empty and have fiery person suitable." therefore the people of all hyperactivity of fire caused by deficiency of YIN chronic cough, often with Radix Panacis Quinquefolii then gas put down fire and hold back, he cough is gradually put down." legendary god of farming's book on Chinese herbal medicine " records Ganoderma " materials for improving vision, QI invigorating, An Jinghun, bone and muscle strengthening, good color, eat for a long time, and make light of one's life by commiting suicide not old, prolong life angle ".The medicine that Compendium of Material Medica is referred to as, it is warm in nature lightly seasoned, nontoxic, the beneficial motive, and invigorating middle warmer increases intelligence, and food is made light of one's life by commiting suicide not old for a long time, life lengthening.Fructus Lycii is that maturation of Solanaceae undershrub Fructus Lycii is real, and both having can be used as nut and eaten, is again the Chinese medicine material that effect is distinguished simply, is usually taken good care of and antidotal good medicine by as nourishing.Pharmacology and clinical research at all times all proves, Fructus Lycii truly have prevent and cure diseases, effect of life lengthening.Herba Dendrobii Yin-nourishing and body fluid promoting in this compound preparation, joins Radix Panacis Quinquefolii boosting qi and nourishing yin, joins Ganoderma invigorating QI and tranquilization, joins Fructus Lycii nourishing the liver and kidney, closes and uses it.Both be suitable for the body of vital essence deficiency, be suitable for again the people of YIN fluid deficiency, for deficiency of both the lung and kidney, deficiency of both vital energy and Yin, fatigue and weakness, lumbocrural pain, the few expectorant of cough, dry mouth and throat, deficient pulse weak person.
Compared with prior art, tool has the following advantages:
In the present invention, Herba Dendrobii Yin-nourishing and body fluid promoting, joins Radix Panacis Quinquefolii boosting qi and nourishing yin, joins Ganoderma invigorating QI and tranquilization, joins Fructus Lycii nourishing the liver and kidney, closes and uses it.Herba Dendrobii, Fructus Lycii, Radix Panacis Quinquefolii to become with Ganoderma four kinds deciliter and with can produce synergism.Both be suitable for the body of vital essence deficiency, be suitable for again the people of YIN fluid deficiency, for deficiency of both the lung and kidney, deficiency of both vital energy and Yin, fatigue and weakness, lumbocrural pain, the few expectorant of cough, dry mouth and throat, deficient pulse weak person.Herba Dendrobii compound preparation of the present invention is applicable to immunocompromised person, fatiguability person, middle-aged and elderly people and be in all kinds of crowds of sub-health state, also can be used for the rehabilitation after cancer patient chemicotherapy.
The preparation method of Herba Dendrobii compound preparation of the present invention, its preparation is simple, is easy to suitability for industrialized production, possesses wide application prospect.
Accompanying drawing explanation
Fig. 1 is the process chart of the preparation method of Herba Dendrobii compound preparation of the present invention.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but these embodiments must not be used for explaining limiting the scope of the invention.
Embodiment 1
As shown in Figure 1, Herba Dendrobii compound granule is prepared according to the production technology shown in Fig. 1;
The present embodiment Herba Dendrobii compound granule, its crude drug proportioning is:
Principal agent: Herba Dendrobii 30g, Radix Panacis Quinquefolii 30g, Fructus Lycii (Fructus Lycii decoction pieces) 20g, Ganoderma (lucid ganoderma decoction piece) 10g; Adjuvant: DEXTRIN g.
Be prepared according to following concrete mode:
(1) Herba Dendrobii, Radix Panacis Quinquefolii powder are broken into coarse powder, cross 30 mesh sieves, for subsequent use, obtain powdery Herba Dendrobii and Radix Panacis Quinquefolii coarse powder;
(2) Radix Panacis Quinquefolii coarse powder, add the aqueous solution heating and refluxing extraction 2 times that 16 times amount mass percents are 70% ethanol, namely be 1:16 in the Radix Panacis Quinquefolii of powdery and the weight ratio of ethanol water, each 3 hours, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, merge extractive liquid, 65 DEG C ~ 75 DEG C decompressions (-0.04 ~-0.08MPa) concentrate, reclaim ethanol, obtain Radix Panacis Quinquefolii extractum (extractum I), for subsequent use;
(3) Radix Panacis Quinquefolii alcohol extraction slag is together with powdery Herba Dendrobii, Fructus Lycii decoction pieces, lucid ganoderma decoction piece, the purified water adding 30 times of weight decocts 2 times, namely Radix Panacis Quinquefolii alcohol extraction slag, powdery Herba Dendrobii, Fructus Lycii and the gross weight of Ganoderma and the weight ratio of water are 1:30, each 4 hours, collecting decoction, filters, filtrate 70 DEG C ~ 80 DEG C concentrating under reduced pressure (-0.04 ~-0.08MPa), obtain the water extracted immersing paste (extractum II), for subsequent use;
(4) step (2) and (3) gained extractum are merged mixing, spray-dried extract fine powder (i.e. extract powder), mistake 80 mesh sieves, for subsequent use;
(5) by obtained for step (4) extract fine powder and the dextrin boiling granulating on fluid bed granulator crossing 80 mesh sieves, granulate, obtains Herba Dendrobii compound granule.
The present embodiment Herba Dendrobii compound granule, adult daily twice, each 3g.
Embodiment 2
The present embodiment Herba Dendrobii compound granule, its crude drug proportioning is:
Principal agent: Herba Dendrobii 30g, Radix Panacis Quinquefolii 20g, Fructus Lycii (Fructus Lycii decoction pieces) 20g, Ganoderma (lucid ganoderma decoction piece) 20g; Adjuvant: glucose 40g.
Preparation method is with embodiment 1.
Embodiment 3
The present embodiment Herba Dendrobii compound tablet, its crude drug proportioning is:
Principal agent: Herba Dendrobii 30g, Fructus Lycii (Fructus Lycii decoction pieces) 20g, Radix Panacis Quinquefolii 30g, Ganoderma (lucid ganoderma decoction piece) 20g; Adjuvant: D-mannital 20g, magnesium stearate 0.5g.
Preparation method:
(1) Herba Dendrobii, Radix Panacis Quinquefolii powder are broken into coarse powder, cross 30 mesh sieves, for subsequent use, obtain powdery Herba Dendrobii and Radix Panacis Quinquefolii coarse powder;
(2) Radix Panacis Quinquefolii coarse powder, adds 16 times amount (weight) mass fraction 70% ethanol water heating and refluxing extraction 2 times, each 3 hours, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, merge extractive liquid, 65 DEG C ~ 75 DEG C concentrating under reduced pressure, reclaim ethanol, obtain Radix Panacis Quinquefolii extractum, for subsequent use;
(3) Radix Panacis Quinquefolii alcohol extraction slag is together with powdery Herba Dendrobii, Fructus Lycii decoction pieces, lucid ganoderma decoction piece, adds 30 times amount soak by water 2 times, each 4 hours, collecting decoction, and filter, filtrate 70 DEG C ~ 80 DEG C concentrating under reduced pressure, obtain Radix Panacis Quinquefolii extractum, for subsequent use;
(4) step (2) and (3) gained extractum are merged mixing, spray-dried extract fine powder, crosses 80 mesh sieves, for subsequent use;
(5) by obtained for step (4) extract fine powder and the D-mannital boiling granulating on fluid bed granulator crossing 80 mesh sieves, granulate, obtains granule, for subsequent use;
(6) mixed homogeneously with the magnesium stearate crossing 80 mesh sieves by obtained for step (5) granule, tabletting, packaging, obtains compound dendrobium officinale tablet.
The present embodiment, adult daily twice, each 3.
Embodiment 4
The present embodiment Herba Dendrobii compound capsule, its crude drug proportioning is:
Principal agent: Herba Dendrobii 30g, Radix Panacis Quinquefolii 30g, Fructus Lycii (Fructus Lycii decoction pieces) 20g, Ganoderma (lucid ganoderma decoction piece) 20g; Adjuvant: microcrystalline Cellulose 10g, micropowder silica gel 0.5g.
Preparation method:
(1) Herba Dendrobii, Radix Panacis Quinquefolii powder are broken into coarse powder, cross 30 mesh sieves, for subsequent use, obtain powdery Herba Dendrobii and Radix Panacis Quinquefolii coarse powder;
(2) Radix Panacis Quinquefolii coarse powder, adds 16 times amount (weight) mass percent 70% ethanol water heating and refluxing extraction 2 times, each 3 hours, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, merge extractive liquid, 65 DEG C ~ 75 DEG C concentrating under reduced pressure, reclaim ethanol, obtain Radix Panacis Quinquefolii extractum, for subsequent use;
(3) Radix Panacis Quinquefolii alcohol extraction slag is together with powdery Herba Dendrobii, Fructus Lycii decoction pieces, lucid ganoderma decoction piece, adds 30 times amount soak by water 2 times, each 4 hours, collecting decoction, and filter, filtrate 70 DEG C ~ 80 DEG C concentrating under reduced pressure, obtain the water extracted immersing paste, for subsequent use;
(4) step (2) and (3) gained extractum are merged mixing, spray-dried extract fine powder, crosses 80 mesh sieves, for subsequent use;
(5) by obtained for step (4) extract fine powder and the microcrystalline Cellulose boiling granulating on fluid bed granulator crossing 80 mesh sieves, granule is obtained, for subsequent use;
(6) mixed homogeneously with the micropowder silica gel of crossing 80 mesh sieves by obtained for step (5) granule, fill capsule, packaging, obtains compound dendrobium officinale capsule.
The present embodiment, adult daily twice, each 3.
Comparative example 1
The present embodiment Herba Dendrobii compound granule, its crude drug proportioning is:
Principal agent: Herba Dendrobii 34g, Radix Panacis Quinquefolii 34g, Fructus Lycii (Fructus Lycii decoction pieces) 22g; Adjuvant: DEXTRIN g.
Be prepared according to following concrete mode:
(1) Herba Dendrobii, Radix Panacis Quinquefolii powder are broken into coarse powder, cross 30 mesh sieves, for subsequent use, obtain powdery Herba Dendrobii and Radix Panacis Quinquefolii coarse powder;
(2) Radix Panacis Quinquefolii coarse powder, add the aqueous solution heating and refluxing extraction 2 times that 16 times amount mass percents are 70% ethanol, namely be 1:16 in the Radix Panacis Quinquefolii of powdery and the weight ratio of ethanol water, each 3 hours, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, merge extractive liquid, 65 DEG C ~ 75 DEG C concentrating under reduced pressure, reclaim ethanol, obtain Radix Panacis Quinquefolii extractum, for subsequent use;
(3) Radix Panacis Quinquefolii alcohol extraction slag is together with powdery Herba Dendrobii, Fructus Lycii decoction pieces, the purified water adding 30 times of weight decocts 2 times, namely the gross weight of Radix Panacis Quinquefolii alcohol extraction slag, powdery Herba Dendrobii and Fructus Lycii and the weight ratio of water are 1:30, each 4 hours, collecting decoction, filters, filtrate 70 DEG C ~ 80 DEG C concentrating under reduced pressure, obtain the water extracted immersing paste, for subsequent use;
(4) step (2) and (3) gained extractum are merged mixing, spray-dried extract fine powder, crosses 80 mesh sieves, for subsequent use;
(5) by obtained for step (4) extract fine powder and the dextrin boiling granulating on fluid bed granulator crossing 80 mesh sieves, granulate, obtains the agent of Herba Dendrobii plain particles.
The test of pesticide effectiveness
Confirm that this product has the function of enhancing immunity and alleviating physical fatigue through zoopery.
One, enhancing immunity function test
Per os gives this product 1 month of mice various dose, result shows, and this product has rising hydrocortisone model mice peripheral white blood cell, increases model mouse thymus, index and spleen index, strengthen the phagocytic function of macrophage, promote model mouse cellular immune function.Therefore think that this product has the function of enhancing immunity.
1 materials and methods
1.1 material
1.1.1 sample: Herba Dendrobii compound granule prepared by embodiment 1, specification: 4.0g/ bag, in June, 2013 manufactures experimently; Herba Dendrobii plain particles agent prepared by comparative example 1.
1.1.2 laboratory animal: cleaning grade ICR mice 180, male and female half and half, body weight 18 ~ 22g.Thered is provided by Zhejiang Academy of Medical Sciences Experimental Animal Center, the animal quality certification number: SCXK (Zhejiang) 2008-0033.
1.1.3 main agents: india ink, sheep red blood cell (SRBC) (SRBC).
1.1.4 key instrument: analytical balance, spectrophotometer, microsyringe (50ul), slide gauge (precision 0.02mm), ultramicroscope.
1.2 method
1.2.1 healthy mice 60 is got, male and female half and half to the impact of hydrocortisone model mice leukocyte count and thymus, index and spleen index, be divided into 6 groups at random, in table 1 by body weight.Normal group, model control group mice gavage every day gives normal saline 0.01mLg
-1, administration group by table 1 dosage respectively gavage give Herba Dendrobii compound granular, namely dosage is respectively 0.4gkg
-1body weight, 1.2gkg
-1body weight and 4.0gkg
-1body weight, is respectively low dosage administration group, middle dosed administration group and high dose administration group, every day 1 time, continuous 30 days.Adopt the Herba Dendrobii plain particles agent of comparative example 1 preparation with 1.2gkg
-1body weight medicine feed is comparative example 1 group.Except normal group, other each group starts subcutaneous injection hydrocortisone (40mgkg on the 18th day in experiment
-1) 5 times, inject 1 time every other day.After last administration 1.5h, mouse orbit is taken a blood sample, and measures leukocyte count, and puts to death animal with cervical dislocation, takes thymus, spleen weighing, calculates organ index, then carry out statistical disposition with t inspection.
1.2.2 together 1.2.1 is tested to affect mice group, administration and the modeling of hydrocortisone model mice macrophage phagocytic function.After last administration 1h, each group mouse tail vein injection india ink (with normal saline dilution 4 times) 0.01mLg
-1, after injecting, when 2min, 10min, eye socket gets blood 20uL respectively, is dissolved in 2mL 0.1% (wt) aqueous sodium carbonate, shakes up, and in 600nm wavelength place colorimetric, measures and absorbs angle value, calculate phagocytic index a.Phagocytic index a=(logA1-logA2) ÷ (t1-t2).
1.2.3 healthy mice 60 is got, male and female half and half to the impact of sheep red blood cell (SRBC) (SRBC) inducing mouse swelling degree of the paw, be divided into 6 groups at random, in table 3 by body weight.Normal group, model group mice gavage every day normal saline 0.01mLg
-1, administration group presses Herba Dendrobii compound granular 0.4gkg respectively
-1body weight, 1.2gkg
-1body weight and 4.0gkg
-1the dosage gastric infusion of body weight, comparative example 1 group is according to Herba Dendrobii plain particles agent 1.2gkg
-1the dosage gastric infusion of body weight.Every day 1 time, continuous 30 days.After 30 days, except normal group, lumbar injection 2% (wt) SRBC, every injected in mice 0.2ml (about 1 × 10
8individual SRBC).Immunity, after 4 days, measures left back sufficient sole of the foot portion thickness or swelling, then at measuring point subcutaneous injection 20% (V/V) SRBC, and every Mus 20ul (about 1 × 10
8individual SRBC), after injection, 24h measures left back sufficient sole of the foot portion thickness or swelling, and same Site Determination three times, averages.
2 results
2.1 impacts on murine interleukin number and thymus, index and spleen index
Result is as shown in table 1, compares with model control group, Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1effectively can resist the sharply decline of the peripheral white blood cell caused by hydrocortisone, alleviate the side effect of hydrocortisone application, and the immune organ that can effectively suppress hydrocortisone to cause secrete lymphocytic minimizing; Compared with Normal group, Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1the effect of peripheral blood leucocyte can be promoted more significantly, the propagation (P<0.05) of Promote immunity organ.
for mean+SD.
Table 1 Herba Dendrobii compound granular on the impact of model mice leukocyte count and thymus, index and spleen index (n=10,
)
Note: compare with normal group, ##:P<0.01; Compare with model group, *: P<0.05.
2.2 impacts on hydrocortisone model mice carbonic clearance index
Result is as shown in table 2, compared with model control group, and Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1the mice carbon clearance speed caused after effectively suppressing hydrocortisone to add slows down; Compare with Normal group, Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1grazing rate a can be significantly improved, increase mice carbon clearance ability.
Table 2 Herba Dendrobii compound granular is on the impact of hydrocortisone model mice carbon clearance speed
(n＝10,
)
| Group | Dosage/gkg -1 | Phagocytic index a |
| Normal group | - | 4.478±0.44 |
| Model control group | - | 3.528±0.93 ## |
| Low dosage administration group | 0.4 | 3.824±0.71 |
| Middle dosed administration group | 1.2 | 4.314±0.78 |
| High dose administration group | 4.0 | 4.361±0.61* |
| Comparative example 1 group | 1.2 | 3.801±0.67 |
Note: compare with normal group, ##:P<0.01; Compare with model group, *: P<0.05.
2.3 impacts on sheep red blood cell (SRBC) (SRBC) inducing mouse swelling degree of the paw
Result is as shown in table 3, and the swelling degree of the paw of model control group, compared with matched group, has significant significant difference (P<0.01).Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1significantly can reduce the pedal swelling degree that sheep red blood cell (SRBC) (SRBC) sensitization causes, effectively promote cellular immunization.Compared with normal group, Herba Dendrobii compound granular 1.2gkg
-1, 4.0gkg
-1can effectively promote mice delayed allergy, promote cellular immune function (P<0.05, P<0.01).
Table 3 Herba Dendrobii compound granular is on the impact of sheep red blood cell (SRBC) inducing mouse swelling degree of the paw
(n＝10,
)
| Group | Dosage/gkg -1 | Swelling/% |
| Normal group | - | 18.75±3.88 |
| Model control group | - | 30.90±4.56 ## |
| Low dosage administration group | 0.4 | 26.72±7.92 |
| Middle dosed administration group | 1.2 | 24.37±7.83* |
| High dose administration group | 4.0 | 20.42±5.12** |
| Comparative example 1 group | 1.2 | 26.12±7.77* |
Note: compare with normal group, ##:P<0.01; Compare with model group, *: P<0.05, * *: P<0.01.
3, conclusion
This research prompting Herba Dendrobii compound granule has rising hydrocortisone model mice peripheral white blood cell, increases model mouse thymus, index and spleen index, strengthens the phagocytic function of macrophage, promote model mouse cellular immune function.Show that said preparation has immunological enhancement, can the specificity of enhancing body and non-specific immunity.And its effect obviously will be better than comparative example 1 group, visible, in the present invention, Herba Dendrobii Yin-nourishing and body fluid promoting, joins Radix Panacis Quinquefolii boosting qi and nourishing yin, joins Ganoderma invigorating QI and tranquilization, join Fructus Lycii nourishing the liver and kidney, four kinds to become deciliter and with can produce synergism, there is good immunological enhancement, better the specificity of enhancing body and non-specific immunity.
Claims (10)
1. a Herba Dendrobii compound preparation, is characterized in that, is made up of the raw material of following percentage by weight:
2. Herba Dendrobii compound preparation according to claim 1, is characterized in that, is made up of the raw material of following percentage by weight:
3. the preparation method of Herba Dendrobii compound preparation according to claim 1 and 2, is characterized in that, comprise the following steps:
(1) Herba Dendrobii is broken into powder, obtains powdery Herba Dendrobii;
(2) Radix Panacis Quinquefolii is broken into powder, adds the ethanol water heating and refluxing extraction that mass fraction is 60% ~ 80%, obtained extracting solution and Radix Panacis Quinquefolii alcohol extraction slag, extracting solution, through concentrating under reduced pressure, obtains Radix Panacis Quinquefolii extractum;
(3) the Radix Panacis Quinquefolii alcohol extraction slag in step (2), the powdery Herba Dendrobii in step (1), Fructus Lycii and Ganoderma are decocted with water, obtain decocting liquid, decocting liquid obtains filtrate after filtering, and filtrate, through concentrating under reduced pressure, obtains the water extracted immersing paste;
(4) the water extracted immersing paste that Radix Panacis Quinquefolii extractum step (2) obtained and step (3) obtain merges mixing, spray-driedly obtains pharmaceutically active powder;
(5) add adjuvant by the pharmaceutically active powder obtained in step (4), prepare Herba Dendrobii compound preparation.
4. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (1), Herba Dendrobii is broken into powder, crosses 30 mesh sieves, obtains powdery Herba Dendrobii;
In step (2), Radix Panacis Quinquefolii is broken into powder, after crossing 30 mesh sieves, adds the ethanol water heating and refluxing extraction that mass fraction is 60% ~ 80%.
5. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (2), the Radix Panacis Quinquefolii in powdery and the weight ratio of ethanol water are 1:10 ~ 20.
6. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (2), described heating and refluxing extraction is 2 ~ 3 times, each 2 ~ 4 hours, merge extractive liquid.
7. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (2), described extracting solution is 65 DEG C ~ 75 DEG C through the temperature of concentrating under reduced pressure;
In step (3), described filtrate is 70 DEG C ~ 80 DEG C through the temperature of concentrating under reduced pressure.
8. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (3), described Radix Panacis Quinquefolii alcohol extraction slag, powdery Herba Dendrobii, Fructus Lycii and the gross weight of Ganoderma and the weight ratio of water are 1:25 ~ 35.
9. the preparation method of Herba Dendrobii compound preparation according to claim 3, is characterized in that, in step (3), described decocting with water obtains decocting liquid and be: decoct with water 2 ~ 3 times successively, each 3 ~ 5 hours, collecting decoction afterwards.
10. the application of Herba Dendrobii compound preparation according to claim 1 and 2 in the health product preparing enhancing immunity and alleviating physical fatigue and medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410632144.9A CN104435749B (en) | 2014-11-11 | 2014-11-11 | A kind of dendrobium candidum compound preparation and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410632144.9A CN104435749B (en) | 2014-11-11 | 2014-11-11 | A kind of dendrobium candidum compound preparation and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104435749A true CN104435749A (en) | 2015-03-25 |
| CN104435749B CN104435749B (en) | 2018-01-16 |
Family
ID=52883010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410632144.9A Active CN104435749B (en) | 2014-11-11 | 2014-11-11 | A kind of dendrobium candidum compound preparation and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104435749B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105077051A (en) * | 2015-04-16 | 2015-11-25 | 闽南师范大学 | Functional food containing Dendrobium officinale and longan and preparation method thereof |
| CN105124584A (en) * | 2015-09-14 | 2015-12-09 | 广西经正科技开发有限责任公司 | Dendrobium officinale compound health-care oral solution and preparation method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN105796942A (en) * | 2016-03-10 | 2016-07-27 | 厦门塔斯曼生物工程有限公司 | Formula for improving physical strength of animal or human body |
| CN107582865A (en) * | 2017-09-11 | 2018-01-16 | 浙江寿仙谷医药股份有限公司 | A kind of pharmaceutical composition and preparation method thereof with fatigue-relieving, strengthen immunity effect |
| CN107812112A (en) * | 2017-12-05 | 2018-03-20 | 浙江省医学科学院 | A kind of dendrobium candidum compound wine and its preparation method and application |
| CN107904103A (en) * | 2017-12-05 | 2018-04-13 | 浙江民康天然植物制品有限公司 | A kind of dendrobium candidum health liquor and its preparation method and application |
| CN109363174A (en) * | 2018-10-31 | 2019-02-22 | 吉林省恒实传食品科技发展有限公司 | A kind of strengthen immunity, the health care's food for alleviating physical fatigue and preparation method thereof |
| CN111686207A (en) * | 2020-06-19 | 2020-09-22 | 杭州医学院 | Dendrobium devonianum compound preparation and preparation method and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060100797A (en) * | 2005-03-18 | 2006-09-21 | 주식회사 홍선 | A method for producing a strained rice wine with oriental medicines |
| CN101152007A (en) * | 2007-10-19 | 2008-04-02 | 金华寿仙谷药业有限公司 | Health-care products composition and method for preparing the same |
| CN101664185A (en) * | 2009-09-07 | 2010-03-10 | 北京同仁堂健康药业股份有限公司 | Food and medicament for enhancing immunity and relieving physical fatigue and preparation method |
| CN101757453A (en) * | 2010-03-03 | 2010-06-30 | 澳诺（中国）制药有限公司 | American ginseng-glossy ganoderma-dendrobe preparation and preparation method thereof |
| CN102266491A (en) * | 2011-07-15 | 2011-12-07 | 安徽圣农生物科技股份有限公司 | Formula of compound dendrobium huoshanense extract and production process thereof |
| CN102415568A (en) * | 2011-12-13 | 2012-04-18 | 常熟雷允上制药有限公司 | Health food for improving immunity and preparation method thereof |
| CN103007052A (en) * | 2012-12-14 | 2013-04-03 | 上海绿谷制药有限公司 | Compound dendrobium extract composition capable of delaying senility |
| CN104127577A (en) * | 2014-08-12 | 2014-11-05 | 安徽衡济堂灵芝产业开发有限公司 | Chinese medicine capsule for relieving physical fatigue and preparation method of Chinese medicine capsule |
-
2014
- 2014-11-11 CN CN201410632144.9A patent/CN104435749B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060100797A (en) * | 2005-03-18 | 2006-09-21 | 주식회사 홍선 | A method for producing a strained rice wine with oriental medicines |
| CN101152007A (en) * | 2007-10-19 | 2008-04-02 | 金华寿仙谷药业有限公司 | Health-care products composition and method for preparing the same |
| CN101664185A (en) * | 2009-09-07 | 2010-03-10 | 北京同仁堂健康药业股份有限公司 | Food and medicament for enhancing immunity and relieving physical fatigue and preparation method |
| CN101757453A (en) * | 2010-03-03 | 2010-06-30 | 澳诺（中国）制药有限公司 | American ginseng-glossy ganoderma-dendrobe preparation and preparation method thereof |
| CN102266491A (en) * | 2011-07-15 | 2011-12-07 | 安徽圣农生物科技股份有限公司 | Formula of compound dendrobium huoshanense extract and production process thereof |
| CN102415568A (en) * | 2011-12-13 | 2012-04-18 | 常熟雷允上制药有限公司 | Health food for improving immunity and preparation method thereof |
| CN103007052A (en) * | 2012-12-14 | 2013-04-03 | 上海绿谷制药有限公司 | Compound dendrobium extract composition capable of delaying senility |
| CN104127577A (en) * | 2014-08-12 | 2014-11-05 | 安徽衡济堂灵芝产业开发有限公司 | Chinese medicine capsule for relieving physical fatigue and preparation method of Chinese medicine capsule |
Non-Patent Citations (1)
| Title |
|---|
| 无: "石斛灵芝西洋参枸杞能混在一起泡茶喝吗", 《HTTP://3G.CLUB.XYWY.COM/STATIC/20160215/12196479.HTM》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105077051A (en) * | 2015-04-16 | 2015-11-25 | 闽南师范大学 | Functional food containing Dendrobium officinale and longan and preparation method thereof |
| CN105124584A (en) * | 2015-09-14 | 2015-12-09 | 广西经正科技开发有限责任公司 | Dendrobium officinale compound health-care oral solution and preparation method thereof |
| CN105663770A (en) * | 2016-02-18 | 2016-06-15 | 云南久丽康源石斛开发有限公司 | Dendrobium officinale capsule with liver caring function and making method thereof |
| CN105796942A (en) * | 2016-03-10 | 2016-07-27 | 厦门塔斯曼生物工程有限公司 | Formula for improving physical strength of animal or human body |
| CN107582865A (en) * | 2017-09-11 | 2018-01-16 | 浙江寿仙谷医药股份有限公司 | A kind of pharmaceutical composition and preparation method thereof with fatigue-relieving, strengthen immunity effect |
| CN107812112A (en) * | 2017-12-05 | 2018-03-20 | 浙江省医学科学院 | A kind of dendrobium candidum compound wine and its preparation method and application |
| CN107904103A (en) * | 2017-12-05 | 2018-04-13 | 浙江民康天然植物制品有限公司 | A kind of dendrobium candidum health liquor and its preparation method and application |
| CN107812112B (en) * | 2017-12-05 | 2020-12-11 | 浙江省医学科学院 | Dendrobium officinale compound wine and preparation method and application thereof |
| CN109363174A (en) * | 2018-10-31 | 2019-02-22 | 吉林省恒实传食品科技发展有限公司 | A kind of strengthen immunity, the health care's food for alleviating physical fatigue and preparation method thereof |
| CN111686207A (en) * | 2020-06-19 | 2020-09-22 | 杭州医学院 | Dendrobium devonianum compound preparation and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104435749B (en) | 2018-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104435748A (en) | Dendrobium officinale compound preparation as well as preparation method and application of dendrobium officinale compound preparation | |
| CN104435749A (en) | Dendrobium officinale compound preparation as well as preparation method and application of dendrobium officinale compound preparation | |
| CN103007053B (en) | Dendrobium officinale compound preparation as well as preparation method and application thereof | |
| CN104666892A (en) | Sealwort and ginseng formula for enhancing immunity and relieving fatigue and preparation method of formula | |
| CN103191332A (en) | Composition and health-care product with stomach-invigorating and digestion-promoting functions | |
| CN104352804A (en) | Dendrobium candidum compound preparation with functions of invigorating the kidney and strengthening Yang as well as preparation method and application thereof | |
| CN101011562B (en) | Novel formulation of shenqiwendan decoction and production method thereof | |
| JP2002154979A (en) | Medicine composition for i type allergy and method for producing the same | |
| CN102885975A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN101623485B (en) | Dan e women-healthcare granulae | |
| CN110123944A (en) | Rhizoma polygonati Cordyceps militaris preparation | |
| CN104800771A (en) | Traditional Chinese medicine preparation for treating children sleep terror disorder and preparation method thereof | |
| CN102579686B (en) | Traditional Chinese medicine lozenge and preparing method thereof | |
| CN103041233A (en) | Pharmaceutical composition for treating infantile diarrhea and preparation method thereof | |
| CN102631490B (en) | Traditional Chinese medicine composition capable of improving immunity and resisting fatigue | |
| CN105477465A (en) | Chinese herb preparation with liver protection function and preparing technology of Chinese herb preparation | |
| CN104721508A (en) | Pharmaceutical composition for treating upper respiratory infection and preparation method thereof | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN103721229A (en) | Traditional Chinese medicinal composition for treating infantile cough and asthma and preparation method thereof | |
| CN103405574A (en) | Medicinal composition for treating hypertension | |
| CN102631486B (en) | Health care composition | |
| CN111686207A (en) | Dendrobium devonianum compound preparation and preparation method and application thereof | |
| CN118750561A (en) | Traditional Chinese medicine composition for new coronavirus infection recovery period and preparation method and application thereof | |
| CN104096202A (en) | Medicine for treating autumn diarrhea and preparation method of medicine | |
| CN104436021A (en) | Arctium-containing traditional Chinese medicine composition for treating diabetes mellitus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240104 Address after: No. 1 Yunshan Road, Longshan Town, Longling County, Baoshan City, Yunnan Province, 678000 Patentee after: Yunnan Pinhutang Biotechnology Co.,Ltd. Address before: 310013 No. 182 Tianmu Mountain Road, Zhejiang, Hangzhou Patentee before: ZHEJIANG ACADEMY OF MEDICAL SCIENCES |
|
| TR01 | Transfer of patent right |