CN102908489B - Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method of same - Google Patents
Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method of same Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating seborrheic alopecia and a preparation method of the traditional Chinese medicine composition. The Chinese medicine composition has the effects of tonifying qi and yin, nourishing the liver and the kidney and promoting hair growth, and can be used for hair loss caused by kidney essence loss, unconsolidation of vital essence, deficiency of both qi and yin, and blood stasis in pores with the passing of time. The Chinese medicine composition provided by the invention comprises the following drug substances: 10-30 parts of membranous milkvetch root, 5-25 parts of prepared rhizome of rehmannia, 5-10 parts of rhizoma dioscoreae, 5-10 parts of Indian buead, 3-6 parts of boxthorn fruit, 3-6 parts of radix salviae miltiorrhizae, 2-8 parts of roasted atractylis ovata, 2-8 parts of white paeony root, 2-8 parts of bee pollen and 1-5 parts of semen cuscutae. The medicine provided by the invention can be mixed with conventional auxiliary materials and processed into clinically acceptable tablets, granules, pills, capsules, controlled release formulations, oral liquid and the like, according to the conventional process.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, specifically, relate to a kind of Chinese medicine composition for the treatment of seborrheic alopecia and preparation method thereof.
Background technology
Seborrheic alopecia claims again male pattern alopecia, androgenetic alopecia, is the common frdquently encountered disease of department of dermatologry, is also one of refractory disease.Be more common in 20～40 years old male, be apt to occur in the crown and forehead both sides.The primary disease cause of disease is not yet completely clear and definite, there is no at present good Therapeutic Method.Attractive in appearance due to primary disease impact, often bring very large stress and psychological burden to patient, and along with the raising of living standards of the people, the requirement that primary disease is treated is more urgent.
Seborrheic alopecia is the result of multifactor functioning, has both comprised heredity, immunomodulating, also relates to hormone in vivo, local Microinflammation, the variation of the aspects such as somatomedin and cytokine.Current comparatively ideal medicine comes out not yet, treatment in the experience exploration stage.Western medicine can not effect a radical cure primary disease, and untoward reaction is many, and after drug withdrawal, easily recurrence, is therefore difficult to maintain curative effect.The multiplex Radix Polygoni Multiflori of existing Chinese medicine compound, though there is certain curative effect, Radix Polygoni Multiflori has certain toxicity, inapplicable long-term taking.
Summary of the invention
The object of the invention is to openly a kind of Chinese medicine composition for the treatment of seborrheic alopecia, the present invention also aims to the preparation method of open said composition.
A kind of Chinese medicine composition for the treatment of seborrheic alopecia involved in the present invention, it is to be mainly made up of the crude drug Radix Astragali, Rhizoma Dioscoreae, Poria, Radix Rehmanniae Preparata, Fructus Lycii, Semen Cuscutae, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis Macrocephalae (parched), the Radix Paeoniae Alba and bee pollen.
The card that formula of the present invention cures mainly is by due to the loss of suffering from a deficiency of the kidney, monarch drug Radix Astragali invigorating QI to consolidate the body surface resistance, ministerial drug Radix Rehmanniae Preparata life essence-filling, marrow-benefitting, YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating; Rhizoma Dioscoreae, Fructus Lycii, Semen Cuscutae, the Radix Paeoniae Alba has the benefit essence of reinforcing the kidney, and nourishing the liver and kidney is adjuvant drug; Rhizoma Atractylodis Macrocephalae (parched) and Poria spleen invigorating invigorating the spleen and regulating the stomach, Radix Salviae Miltiorrhizae clearing away heat from blood, bee pollen is brought down a fever and is promoted the production of body fluid.Full side share, and plays altogether reinforcing both QI and YIN, nourishing the liver and kidney, effect of the hair growth promoting of bringing down a fever.
Reinforcing both QI and YIN of the present invention, nourishing the liver and kidney, hair growth promoting.For deficiency of the kidney, vital essence is not solid, deficiency of both QI and YIN, the with the passing of time alopecia of blood stasis hair key.Disease sees that hair is sparse and comes off, and companion is dizzy, and tinnitus, breathes hard, dizzy, xerostomia, soreness of the waist and knees.
The consumption of Chinese medicine composition of the present invention and drug component thereof is also groped in a large number to sum up through inventor and is drawn
Composition and the weight portion of a kind of oral Chinese medicine composition for the treatment of seborrheic alopecia of described treatment are: Radix Astragali 10-30 part, Radix Rehmanniae Preparata 5-25 part, Rhizoma Dioscoreae 5-10 part, Poria 5-10 part, Fructus Lycii 3-6 part, Radix Salviae Miltiorrhizae 3-6 part, Rhizoma Atractylodis Macrocephalae (parched) 2-8 part, Radix Paeoniae Alba 2-8 part, bee pollen 2-8 part, Semen Cuscutae 1-5 part.
Further composition and the weight portion of a kind of oral Chinese medicine composition for the treatment of seborrheic alopecia of described treatment are: Radix Astragali 15-25 part, Radix Rehmanniae Preparata 10-20 part, Rhizoma Dioscoreae 6-9 part, Poria 6-9 part, Fructus Lycii 4-5 part, Radix Salviae Miltiorrhizae 4-6 part, Rhizoma Atractylodis Macrocephalae (parched) 3-6 part, Radix Paeoniae Alba 3-7 part, bee pollen 3-7 part, Semen Cuscutae 1-3 part.
Preferred composition and the weight portion of a kind of oral Chinese medicine composition for the treatment of seborrheic alopecia of described treatment are: 18 parts of the Radixs Astragali, 15 parts, Radix Rehmanniae Preparata, 8 parts of Rhizoma Dioscoreaes, 8 parts, Poria, 4 parts of Fructus Lycii, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 4 parts of the Radix Paeoniae Albas, 3 parts of bee pollen, 2 parts of Semen Cuscutae.
Preferred composition and the weight portion of a kind of oral Chinese medicine composition for the treatment of seborrheic alopecia of described treatment are: 20 parts of the Radixs Astragali, 18 parts, Radix Rehmanniae Preparata, 6 parts of Rhizoma Dioscoreaes, 6 parts, Poria, 5 parts of Fructus Lycii, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 5 parts of the Radix Paeoniae Albas, 5 parts of bee pollen, 3 parts of Semen Cuscutae.
In a word, the present invention forms monarch, minister, it is various to help, make, and compatibility is rigorous, complements each other, and plays altogether reinforcing both QI and YIN, nourishing the liver and kidney, the merit of hair growth promoting.
Medicine of the present invention can add conventional adjuvant, according to common process, makes clinical acceptable tablet, granule, pill, capsule, slow releasing agent, oral liquid etc.
The preparation method of Chinese medicine composition of the present invention comprises the steps: that above ten tastes are ground into fine powder, sieves, mix, and granule processed, dry, encapsulated.
The preparation method of the tablet of Chinese medicine composition of the present invention comprises the steps: above ten tastes, is ground into fine powder, sieves, mix, and granule processed, dry, tabletting, makes tablet.
The preparation method of the tablet of Chinese medicine composition of the present invention comprises the steps: after above ten taste decoctings, concentrates, and filters, and makes oral liquid.
The preparation method of Chinese medicine composition of the present invention preferably includes following steps: comprise the steps: above ten tastes, Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make tablet.
The preparation method of Chinese medicine composition of the present invention preferably includes following steps: comprise the steps: above ten tastes, Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make capsule.
Detailed description of the invention
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
1, prescription:
Radix Astragali 18g, Radix Rehmanniae Preparata 15g, Rhizoma Dioscoreae 8g, Poria 8g, Fructus Lycii 4g, Radix Salviae Miltiorrhizae 3g, Rhizoma Atractylodis Macrocephalae (parched) 2g, Radix Paeoniae Alba 4g, bee pollen 3g, Semen Cuscutae 2g.
2. method for making:
Above ten tastes are ground into fine powder, sieve, mix, and granule processed, dry, encapsulated, make 100, to obtain final product.
Embodiment 2
1, prescription:
Radix Astragali 25g, Radix Rehmanniae Preparata 20g, Rhizoma Dioscoreae 7g, Poria 7g, Fructus Lycii 6g, Radix Salviae Miltiorrhizae 3g, Rhizoma Atractylodis Macrocephalae (parched) 2g, Radix Paeoniae Alba 4g, bee pollen 4g, Semen Cuscutae 2g.
2. method for making:
Above ten tastes are ground into fine powder, sieve, mix, and granule processed, dry, tabletting, makes 100, tablet, to obtain final product.
Embodiment 3
1, prescription:
Radix Astragali 20g, Radix Rehmanniae Preparata 18g, Rhizoma Dioscoreae 6g, Poria 6g, Fructus Lycii 5g, Radix Salviae Miltiorrhizae 5g, Rhizoma Atractylodis Macrocephalae (parched) 5g, Radix Paeoniae Alba 5g, bee pollen 5g, Semen Cuscutae 3g.
2, technique:
After above ten taste decoctings, concentrated, filter, make oral liquid 100ml, to obtain final product.
Embodiment 4
1, prescription:
Radix Astragali 25g, Radix Rehmanniae Preparata 20g, Rhizoma Dioscoreae 7g, Poria 7g, Fructus Lycii 6g, Radix Salviae Miltiorrhizae 3g, Rhizoma Atractylodis Macrocephalae (parched) 2g, Radix Paeoniae Alba 4g, bee pollen 4g, Semen Cuscutae 2g.
2. method for making:
Above ten tastes, Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, and after all the other seven flavor medicine decocting in water, are condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make 100 of capsules, to obtain final product.
Embodiment 5
1, prescription:
Radix Astragali 20g, Radix Rehmanniae Preparata 18g, Rhizoma Dioscoreae 6g, Poria 6g, Fructus Lycii 5g, Radix Salviae Miltiorrhizae 5g, Rhizoma Atractylodis Macrocephalae (parched) 5g, Radix Paeoniae Alba 5g, bee pollen 5g, Semen Cuscutae 3g.
2. method for making:
Above ten tastes, Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, and after all the other seven flavor medicine decocting in water, are condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make 100, tablet, to obtain final product.
Embodiment 6 tests of pesticide effectiveness
[test material]
Tested medicine: humagsolan tablet: chocolate brown powder, 0.3g/ grain, is made by embodiment 5, is made into required concentration with front with distilled water.
Testosterone propionate injection: produced specification 10mg/mL, lot number: 050802 by Shanghai General Pharmaceutical Co., ltd..
Positive control drug: spironolactone oral tablet: produced by Hangzhou Minsheng Pharmaceutical Group Co, specification 20mg/ sheet, lot number: T06K532, is mixed with 6% medicinal liquid with distilled water before using.
[test method and result]
Get 60 of Wistar rats, adaptability was fed after 1 week, was divided at random Normal group, seborrheic alopecia model group, positive controls, humagsolan tablet high and low dose group, and totally 5 groups, 10 every group.Before experiment, every rat is chosen the fur of back 1.5cm × 2cm area, with 3% picric acid solution stained yellow to determine the district of losing hair or feathers.Except Normal group, the testosterone propionate of subcutaneous injection 5mg/kgd dosage after all the other each treated animal necks, every day 1 time, continuous 60 days, causes seborrheic alopecia model, subcutaneous injection equal-volume normal saline after normal control treated animal neck.
Administration when modeling, humagsolan tablet high and low dose group is pressed respectively 2.4g/kg, 1.2g/kg gavage humagsolan tablet suspension; Positive controls is pressed 9.0mg/kg gavage spironolactone (SPT) suspension; Model group and Normal group gavage equal-volume normal saline, be 0.5mL/100g.Each group equal every day of gavage 1 time, within 30 days, single cage while there is afterwards depilation symptom is raised, to determine depilation quantity.Notice that every day, observed and recorded dyed hair-fields dyed hair dropping situations, successive administration 60 days afterwards disconnected neck is got blood, detects each treated animal Serum testosterone with putting the method for exempting from, and result is checked and carried out statistical procedures with t.
The results are shown in Table 1.
Impact (the x ± s) of table 1 humagsolan tablet on experimental rat Serum testosterone and depilation quantity
Note: with Normal group comparison
*p < 0.01, with model group comparison,
△ △p < 0.01.
As shown in Table 1, humagsolan tablet high and low dose group all can reduce the depilation quantity of experimental rat, and statistical result has remarkable statistical significance.Humagsolan tablet high dose group can significantly reduce the serum Testosterone of experimental rat, and humagsolan tablet low dose group has the trend of the serum Testosterone that reduces experimental rat.
Embodiment 6 toxicity tests
[test material]
Tested medicine: humagsolan tablet: chocolate brown powder, 0.4g/ grain, is made by embodiment 3, is made into required concentration with front with distilled water.
[test method and result]
Acute toxicity test Kunming mouse 18 ± 2g used, male and female half and half.Selection is bought this laboratory and is adapted to after 3d in good conditionly, and behavior, movable N/R animal are tested.Fasting 14～16h before each animals administer, after administration, fasting 4h, can't help water.Single gastric infusion when experiment, 40mL/kg, wherein blank group waits the distilled water of capacity.Give the response situation of observation post administration animal, and the lasting 4h that observes, Continuous Observation 7d. acute toxicity test observation index: observe animal body quality, diet, outward appearance, behavior, secretions, Excreta and poisoning symptom, the initial time of toxic reaction, the order of severity, persistent period, record the death condition of animal, and respectively before administration the 3rd day (D3) after (D0), administration, the 7th day (D7) claim the animal scale of construction.
In administration 4h and in 1 week, blank group shows no obvious abnormalities reaction, and it is dead that all animals have no.The equal normal growth of each treated animal scale of construction, administration group compares with blank group, difference not statistically significant.This Chinese medicine composition safety non-toxic is described.
Claims (9)
1. a kind of Chinese medicine composition for the treatment of seborrheic alopecia according to claim 1, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: Radix Astragali 15-25 part, Radix Rehmanniae Preparata 10-20 part, Rhizoma Dioscoreae 6-9 part, Poria 6-9 part, Fructus Lycii 4-5 part, Radix Salviae Miltiorrhizae 4-6 part, Rhizoma Atractylodis Macrocephalae (parched) 3-6 part, Radix Paeoniae Alba 3-7 part, bee pollen 3-7 part, Semen Cuscutae 1-3 part.
2. a kind of Chinese medicine composition for the treatment of seborrheic alopecia according to claim 2, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: 18 parts of the Radixs Astragali, 15 parts, Radix Rehmanniae Preparata, 8 parts of Rhizoma Dioscoreaes, 8 parts, Poria, 4 parts of Fructus Lycii, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 4 parts of the Radix Paeoniae Albas, 3 parts of bee pollen, 2 parts of Semen Cuscutae.
3. a kind of Chinese medicine composition for the treatment of seborrheic alopecia according to claim 2, the composition and the weight portion that it is characterized in that the crude drug of making this medicine are: 20 parts of the Radixs Astragali, 18 parts, Radix Rehmanniae Preparata, 6 parts of Rhizoma Dioscoreaes, 6 parts, Poria, 5 parts of Fructus Lycii, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 5 parts of the Radix Paeoniae Albas, 5 parts of bee pollen, 3 parts of Semen Cuscutae.
4. the Chinese medicine composition as described in as arbitrary in claim 1-4, is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes clinical acceptable tablet, granule, pill, capsule, oral liquid.
5. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, comprises the steps: that above ten tastes are ground into fine powder, sieves, mix, and granule processed, dry, encapsulated.
6. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, comprises the steps: above ten tastes, is ground into fine powder, sieves, mix, and granule processed, dry, tabletting, makes tablet.
7. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, comprises the steps: after above ten taste decoctings, concentrated, filters, and makes oral liquid.
8. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, comprises the steps: above ten tastes, and Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, dry, make tablet.
9. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1-4, comprises the steps: above ten tastes, and Rhizoma Dioscoreae, Poria and bee pollen are ground into fine powder, sieve, after all the other seven flavor medicine decocting in water, be condensed into thick paste shape, mix granule processed with above-mentioned fine powder, the dry capsule of making.
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| CN105031145A (en) * | 2015-07-01 | 2015-11-11 | 路贝贝 | Hair-restoring and hair-nourishing traditional Chinese medicine composition |
| CN114392321B (en) * | 2022-03-01 | 2023-01-31 | 北京章光101科技股份有限公司 | A Chinese medicinal composition for preventing alopecia and promoting hair growth, and its preparation method |
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| CN1087267A (en) * | 1992-11-23 | 1994-06-01 | 梅晓春 | A kind of prescription for the treatment of seborrheic alopecia |
| CN1569072A (en) * | 2003-07-26 | 2005-01-26 | 贾祥远 | Compound chinese medicinal oral preparation for treating alopecia areata and alopecia and its preparing method |
| CN101513502B (en) * | 2008-02-22 | 2011-10-26 | 卢明仁 | Hair growth medicament |
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