Pig is used the Chinese herbal medicine multifunctional feed additive
Technical field
The present invention relates to feed addictive, be specifically related to pig and use the Chinese herbal medicine multifunctional feed additive.
Background technology
Utilize Chinese herbal medicine as pig feed additive in the existing long history of China, the record of " the paulownia leaf is raised pig, loose three times, and easily support " as far back as the first two century in Christian era, is just arranged in the Han dynasty medium-height grass monograph " Dragon Lord book on Chinese herbal medicine through ".Also have in the pertinent literature in successive dynasties later on and much mix the record of raising pig with distillers' grains, but do not cause people's attention with Chinese herbal medicine.Up to 19th-century eighties, Chinese herbal medicine just causes scientific and technical personnel's attention gradually as feed addictive, and sets about researching and developing Chinese herbal feed additive.Published " introducing a kind of mixed feeding medicament " paper that Zhong Sentai writes as " feed research " that nineteen eighty-two publishes, reported with cyrtomium fortunei, the bark of ash, the dried immature fruit of citron orange, the root bark of white mulberry, perillaseed etc. and made pulvis, every pig restrains with 12.5-17.5 every day, admixes in the feed, can improve weightening finish 20.5-75.9%.And for example the name of CN1141883C bulletin is called " the medium-height grass additive of pig's feed " patent of invention, disclosing with 12 flavor Chinese herbal medicines such as the Radix Astragali, isatis root, Divine Comedy, hawthorn, Fructus Hordei Germinatus is raw material, through pulverizing, mix, sieve the technical scheme of making the pig's feed additive, this additive adds in the feed, can strengthen the immunity of growth pig, the speed of growth is accelerated, the feed consumption reduces, and does not have the residue of antibiotic, hormone and other chemical composition in the pork, edible safety.Scientific and technical personnel once confirmed with the PPA-ELASA test: Chinese medicines such as the Radix Astragali, Radix Codonopsis, the bighead atractylodes rhizome, the fruit of Chinese magnoliavine have the effect that improves hog cholera immune antibody OD value, also can prolong the time that antibody retains.In addition, a large amount of researchs show that also Chinese herbal medicine is made the feed addictive of pig, can not only improve production performance, reduce feeding cost, and have the immunity of enhancing, anti-stress with multiple function such as health care, and there are not safety and environmental issue, thereby, be subjected to various countries colleague's great attention.But present present situation is, great majority still rest on traditional prescription, compatibility, pulverize, sieve and make the rough stage of pulvis or powder, and quality is wayward, and will its active ingredient separate or extract after make elaboration seldom.The formulation that this is unfavorable for the production of modernized factory, evaluating drug effect and target level of product quality also is unfavorable for controllable quality and applies.
Summary of the invention
The purpose of this invention is to provide a boar and use the Chinese herbal medicine multifunctional feed additive; it is to extract the elaboration that Chinese herbal medicine effective ingredients is made; steady quality; can improve Swine Production efficient; strengthen live pig immunity and anti-stress ability, have preventive care and the effect that improves meat, and safe in utilization; help environmental protection, be fit to modern industrialization production.
Pig of the present invention is used the Chinese herbal medicine multifunctional feed additive, it is characterized in that, and be raw material with folium cortex eucommiae, the fruit of glossy privet, the Radix Astragali, hawthorn and coix seed herbal decoction piece, its percentage by weight is:
Folium cortex eucommiae ... 30%-40%,
The fruit of glossy privet ... 30%-40%,
The Radix Astragali ... 5%-12%,
Hawthorn ... 10%-15%,
Coix seed ... 10%-15%;
Folium cortex eucommiae is warm in nature, flavor is sweet, and the function of filling liver kidney, strengthening the bones and muscles is arranged; The fruit of glossy privet is flat, sweet-bitter flavor, and the function that tonifies the liver and kidney is arranged; The Radix Astragali is warm in nature, flavor is sweet, and the function of invigorating qi for strengthening superficies, Li Shui holder sore is arranged; Hawthorn slightly warm in nature, flavor acid are sweet, have disappear long-pending, change the function that stagnates; Coix seed cold nature, flavor are sweet, and the function of clearing heat and promoting diuresis, invigorating the spleen is arranged.
Prepare by following steps:
(1) weighing and burden: take by weighing folium cortex eucommiae, the fruit of glossy privet, the Radix Astragali, hawthorn and coix seed herbal decoction piece by above-mentioned part by weight;
(2) pulverize to mix: the herbal decoction piece that takes by weighing is ground into meal and mud closes evenly;
(3) alcohol leaching is extracted: the Chinese herbal medicine meal that mixes is packed in " Chinese herbal medicine multi-function extractor ", 70% the alcohol immersion 2 hours that adds 5 times of Chinese herbal medicine meal weight, fed the steam heated refluxing extraction again 2 hours, temperature is controlled between 50 ℃-80 ℃, then, filtering the ethanol extract that obtains stores standby;
(4) water logging is extracted: the dregs of a decoction after preceding operation is filtered are packed in " Chinese herbal medicine multi-function extractor ", add Chinese herbal medicine meal weight 5-8 running water doubly, feed Steam Heating, temperature is controlled between 75 ℃-80 ℃, 1 hour extraction time, then, filter and obtain aqueous extract; The dregs of a decoction after the filtration by after the former method repetition water logging extraction once, are abandoned the dregs of a decoction again;
(5) concentrate ethanol extract: after ethanol extract is staticly settled, get supernatant and pack in " Chinese herbal medicine multi-function extractor ", feed steam heated and reclaim ethanol, temperature is controlled between 80 ℃-85 ℃, then, filter the ethanol extract that obtains concentrating with filter cloth; The active ingredient that contains flavones, saponin class in the ethanol extract that concentrates;
(6) condensed water extract: the aqueous extract that each time obtained merges, pack in " Chinese herbal medicine multi-function extractor ", feed steam heated, temperature is controlled between 70 ℃-80 ℃, make 1-2 that aqueous extract is concentrated into former medicine weight doubly, stop heating then, when temperature is reduced to 50 ℃-60 ℃, add the solution that contains 1% shitosan of volume 5%-15%, left standstill after stirring 24 hours, go precipitation, the aqueous extract that obtains concentrating stores standby; The active ingredient that contains polysaccharide in the aqueous extract that concentrates;
(7) mix ethanol extract and the aqueous extract that concentrates, obtain mixed extract;
(8) spray-drying: in mixed extract is packed into " spray dryer ", the dextrin that adds the 5%-15% of concentrate weight, the heating stirring and dissolving, the inlet temperature of " spray dryer " is controlled at 180 ℃-185 ℃, outlet temperature and is controlled at 70 ℃-80 ℃, then, spray-drying packs the dry medicinal powder that reclaims, and is this additive.
Described pig is used the Chinese herbal medicine multifunctional feed additive, also the medicinal powder that obtains can be added in the carrier, makes pre-mixing agent or granule, so that quality control, preservation, transportation and use.
With about 24 11 kilograms length * honor hybridization castration piglet, be divided into three groups at random, 8 every group; The I group is only fed with basal feed for control group; The II group is raw material powder group, feeds with the basal feed that control group is identical, and adds the raw material meal of the present invention of basal feed weight 2%; The III group is this additive group, feed with the basal feed that control group is identical, and adding is equivalent to 1/2nd these additives that make that II organizes raw materials used meal; After raising identical fate, check feeding effect and liquid immunologic function, relevant data sees Table 1 and table 2.
Table 1 different dosage form and consumption are to INFLUENCE OF YUCCA EXTRACT
Handle | The I group | The II group | The III group |
Examination pig's head number | 8 | 8 | 8 |
The test fate | 122 | 122 | 122 |
Play examination counterpoise (Kg) | 11.50±0.41 | 11.45±0.39 | 11.65±0.41 |
Finish counterpoise (Kg) | 622.6±15.9 | 673.5±22.8 | 681.3±15.9 |
The weight that increases day by day (g) | 622.6±15.9 | 673.5±22.8 | 681.3±15.9 |
Feedstuff-meat ratio | 3.52∶1 | 3.24∶1 | 3.16∶1 |
Table 2 different dosage form is to the influence-hog cholera vaccine immunity qualification rate of pig humoral immune function
Group | The I group | The II group | The III group |
Passing number | 4/8 | 6/8 | 7/8 |
Qualification rate % | 50.0 | 75.0 | 87.5 |
Data declaration from table 1: the live pig of this additive group weight that increases day by day is the highest, and feedstuff-meat ratio is minimum; Data declaration from table 2: the hog cholera vaccine immunity qualification rate of this additive group is the highest.
Select 120 body weight 15g left and right sides healthy mices for use, be divided into 3 groups at random, 40 every group, the I group is control group, only closes basal feed and feeds; The II group is raw material powder group, feeds with the basal feed that control group is identical, and adds the raw material meal of the present invention of basal feed weight 2%; The III group is this additive group, feed with the basal feed that control group is identical, and adding is equivalent to 1/2nd these additives that make that II organizes raw materials used meal.Behind 30 days experimental periods, 20 every group are used for non-specific immune function and measure, and every group of 5 of each picked at random post-tensioning neck of weighing causes death, and strips spleen and weighs, and repeats 4 times.Record body weight and spleen weight calculates spleen index and compares, and result of the test sees Table 3.
Table 3 different dosage form is to the influence-mouse spleen index of animal non-specific immune function
Group | The I group | The II group | The III group |
Spleen index | 4.82±0.24 | 5.07±0.19 | 5.45±0.22 |
Data declaration from table 3: the relative spleen representation work of the small white mouse of this additive group raises, and illustrates that it has the animal of enhancing non-specific immune function.
Each is organized remaining 20 small white mouse and is used for anti-stress test, be every group and make progress again and be equally divided into two groups, 10 every group, place-19 ℃ to-21 ℃ low temperature environment and 41 ℃ to 42 ℃ hot environment respectively, observed 50-60 minute, and write down the mice dying number and survive number.Result of the test sees Table 4.
Table 4 mouse anti stress test result
Stressor | High temperature | Low temperature |
Group | The I group | The II group | The III group | The I group | The II group | The III group |
The survival number | 0/10 | 1/10 | 1/10 | 5/10 | 6/10 | 8/10 |
Survival rate % | 0% | 10% | 10% | 50% | 60% | 80% |
Data declaration from table 4: the Chinese herbal medicine made from raw material of the present invention adds system makes animal to the adaptability of high and low temperature stressor all to some extent, especially obvious with this additive.
The present invention compares with prior art and has the following advantages: can improve Swine Production efficient, reduce feeding cost; Can strengthen immunity and the anti-stress ability of live pig, reduce the incidence of disease; Meat quality be can improve, health of human body and environmental protection helped; Be fit to modernization industry production, constant product quality.
The specific embodiment
Embodiment one:
(1) weighing and burden: take by weighing herbal decoction piece folium cortex eucommiae 30Kg, fruit of glossy privet 35Kg, Radix Astragali 5Kg, hawthorn 15Kg, coix seed 15Kg is a raw material;
(2) pulverize mixing: the raw meal that takes by weighing is broken into meal;
(3) alcohol leaching is extracted: the Chinese herbal medicine meal that mixes is packed in " Chinese herbal medicine multi-function extractor ", 70% the alcohol immersion 2 hours that adds 5 times of Chinese herbal medicine meal weight, fed the steam heated refluxing extraction again 2 hours, temperature is controlled between 50 ℃-80 ℃, then, filtering the ethanol extract that obtains stores standby;
(4) water logging is extracted: the dregs of a decoction after preceding operation is filtered are packed in " Chinese herbal medicine multi-function extractor ", add the running water of 8 times of Chinese herbal medicine meal weight, feed Steam Heating, temperature is controlled between 75 ℃-80 ℃, 1 hour extraction time, then, filter and obtain aqueous extract; The dregs of a decoction after the filtration by after the former method repetition water logging extraction once, are abandoned the dregs of a decoction again;
(5) concentrate ethanol extract: after ethanol extract is staticly settled.Get supernatant and pack in " Chinese herbal medicine multi-function extractor ", feed steam heated and reclaim ethanol, temperature is controlled between 80 ℃-85 ℃, then, filters the ethanol extract that obtains concentrating with filter cloth;
(6) condensed water extract: the aqueous extract that each time obtained merges, pack in " Chinese herbal medicine multi-function extractor ", feed steam heated, temperature is controlled between 70 ℃-80 ℃, make 1-2 that aqueous extract is concentrated into former medicine weight doubly, stop heating then, when temperature was reduced to 60 ℃, the ratio in 10% in concentrate added the solution that contains 1% shitosan, left standstill after stirring 24 hours, go precipitation, the aqueous extract that obtains concentrating stores standby; The active ingredient that contains polysaccharide in the aqueous extract that concentrates;
(7) mix ethanol extract and the aqueous extract that concentrates, obtain mixed extract;
(8) spray-drying: 5% of adding concentrate weight dextrin in mixed extract, the heating stirring and dissolving, carry out spray-drying, the inlet temperature of " spray dryer " is controlled at 180 ℃-185 ℃, outlet temperature and is controlled at 70 ℃-80 ℃, after the spray-drying, the dry medicinal powder that reclaims is packed, be this additive.
Embodiment two:
(1) weighing and burden: take by weighing herbal decoction piece folium cortex eucommiae 40Kg, fruit of glossy privet 30Kg, Radix Astragali 5Kg, hawthorn 15Kg, coix seed 10Kg is a raw material;
(2) pulverize mixing: the raw meal that takes by weighing is broken into meal;
(3) alcohol leaching is extracted: the Chinese herbal medicine meal that mixes is packed in " Chinese herbal medicine multi-function extractor ", 70% the alcohol immersion 2 hours that adds 5 times of Chinese herbal medicine meal weight, fed the steam heated refluxing extraction again 2 hours, temperature is controlled between 50 ℃-80 ℃, then, filtering the ethanol extract that obtains stores standby;
(4) water logging is extracted: the dregs of a decoction after preceding operation is filtered are packed in " Chinese herbal medicine multi-function extractor ", add the running water of 5 times of Chinese herbal medicine meal weight, feed Steam Heating, temperature is controlled between 75 ℃-80 ℃, 1 hour extraction time, then, filter and obtain aqueous extract; The dregs of a decoction after the filtration by after the former method repetition water logging extraction once, are abandoned the dregs of a decoction again;
(5) concentrate ethanol extract: after ethanol extract is staticly settled, get supernatant and pack in " Chinese herbal medicine multi-function extractor ", feed steam heated and reclaim ethanol, temperature is controlled between 80 ℃-85 ℃, then, filter the ethanol extract that obtains concentrating with filter cloth;
(6) condensed water extract: the aqueous extract that each time obtained merges, pack in " Chinese herbal medicine multi-function extractor ", feed steam heated, temperature is controlled between 70 ℃-80 ℃, make 1-2 that aqueous extract is concentrated into former medicine weight doubly, stop heating then, when temperature is reduced to 60 ℃, in concentrate, contain the solution of 1% shitosan in 5% ratio, left standstill after stirring 24 hours, go precipitation, the aqueous extract that obtains concentrating stores standby; The active ingredient that contains polysaccharide in the aqueous extract that concentrates;
(7) mix ethanol extract and the aqueous extract that concentrates, obtain mixed extract;
(8) spray-drying: 10% of adding concentrate weight dextrin in mixed extract, the heating stirring and dissolving, carry out spray-drying, the inlet temperature of " spray dryer " is controlled at 180 ℃-185 ℃, outlet temperature and is controlled at 70 ℃-80 ℃, then, spray-drying packs the dry medicinal powder that reclaims, and is this additive.
Embodiment three:
(1) weighing and burden: take by weighing herbal decoction piece folium cortex eucommiae 40Kg, fruit of glossy privet 30Kg, Radix Astragali 10Kg, hawthorn 10Kg, coix seed 10Kg is a raw material;
(2) pulverize mixing: the raw meal that takes by weighing is broken into meal;
(3) alcohol leaching is extracted: the Chinese herbal medicine meal that mixes is packed in " Chinese herbal medicine multi-function extractor ", 70% the alcohol immersion 2 hours that adds 5 times of Chinese herbal medicine meal weight, fed the steam heated refluxing extraction again 2 hours, temperature is controlled between 50 ℃-80 ℃, then, filtering the ethanol extract that obtains stores standby;
(4) water logging is extracted: the dregs of a decoction after preceding operation is filtered are packed in " Chinese herbal medicine multi-function extractor ", add the running water of 5 times of Chinese herbal medicine meal weight, feed Steam Heating, temperature is controlled between 75 ℃-80 ℃, 1 hour extraction time, then, filter and obtain aqueous extract; The dregs of a decoction after the filtration by after the former method repetition water logging extraction once, are abandoned the dregs of a decoction again;
(5) concentrate ethanol extract: after ethanol extract is staticly settled, get supernatant and pack in " Chinese herbal medicine multi-function extractor ", feed steam heated and reclaim ethanol, temperature is controlled between 80 ℃-85 ℃, then, filter the ethanol extract that obtains concentrating with filter cloth;
(6) condensed water extract: the aqueous extract that each time obtained merges, pack in " Chinese herbal medicine multi-function extractor ", feed steam heated, temperature is controlled between 70 ℃-80 ℃, make 1-2 that aqueous extract is concentrated into former medicine weight doubly, stop heating then, when temperature is reduced to 60 ℃, add the solution that contains 1% shitosan of volume 15%, left standstill after stirring 24 hours, go precipitation, the aqueous extract that obtains concentrating stores standby; The active ingredient that contains polysaccharide in the aqueous extract that concentrates;
(7) mix ethanol extract and the aqueous extract that concentrates, obtain mixed extract;
(8) spray-drying: 15% of adding concentrate weight dextrin in mixed extract, the heating stirring and dissolving, carry out spray-drying, the inlet temperature of " spray dryer " is controlled at 180 ℃-185 ℃, outlet temperature and is controlled at 70 ℃-80 ℃, then, spray-drying packs the dry medicinal powder that reclaims, and is this additive.
Also this additive medicinal powder that makes can be added in the carrier and make pre-mixing agent or granule.