CN103535529A - Traditional Chinese medicine feed additive, preparation method of additive, and feed containing additive - Google Patents
Traditional Chinese medicine feed additive, preparation method of additive, and feed containing additive Download PDFInfo
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Abstract
The invention belongs to the technical field of animal feeds and relates to a traditional Chinese medicine feed additive, a preparation method of the additive, and a feed containing the additive. The traditional Chinese medicine feed additive comprises the materials by weight percentage: 1-30% of astragalus polysaccharide, 1-20% of herba epimedii saponin, 1-20% of glossy privet fruit polysaccharide, 1-20% of lycium barbarum polysaccharide and 10-60% of auxiliary materials. The preparation method of the feed composite additive comprises the steps: adding the obtained materials into a three-dimensional mixing machine according to a mass ratio for fully mixing, wherein the stirring speed of the three-dimensional mixing machine is 10-400r/min, and the stirring time lasts for 0.1-1h; mixing fully, performing split charging and sealing. According to the animal feed, the additive accounts for 0.1-1.2% of the mass of the feed. The additive disclosed by the invention is pure, and free from antibiotics, pesticides and heavy metal residual, the mixing is performed by using the three-dimensional mixing machine, powder is prepared by using a spraying method, and the quality is controlled.
Description
Technical field
The invention belongs to technical field of animal, the feed that is specifically related to a kind of Chinese herbal feed additive and preparation method thereof and contains this additive.
Background technology
Along with antibiotic, chemicals and the hormone medicine abuse as feed addictive, the bacterial drug resistance enhancing that it causes, medicament residue, animal teratogenesis and harm of ecological environment etc. is become clear day by day.Along with synthetic antibacterial agents, antibiotic, hormone etc. are long-term, use the day by day serious of the problem of bringing, people have turned to the notice of feed addictive research to utilize Chinese herbal medicine as feed addictive gradually.Chinese herbal medicine is prepared feed addictive, and its natural sex is good, toxic and side effect is little, be difficult for the advantages such as generation bacterial drug resistance, is that antibiotic and chemical synthetic drug are incomparable.Chinese herbal medicine also contains multiple natural nutrient component, as vitamin, mineral matter and other trace elements etc., when preventing and curing diseases, can also urge growth of animal, strengthens immunity function, improve resistance against diseases, realizes the unification of medical value and nutritive value.
Research shows, Chinese herbal medicine aspect the weightening finish of livestock and poultry and immunologic function with antibiotic no significant difference, for antibiotic, Chinese herbal medicine contains plurality of active ingredients, its effect is many target spots, the lower difficult generation drug resistance of toxicity.But the general direct employing Chinese herbal medicine of current Chinese herb feed additive is used as medicine, there is following technical problem in it: herbal powder that directly take after pulverizing (1) is prepared as raw material, cause a large amount of dust, heavy metal and a large amount of pollutant that Chinese medicine carries to be together mixed in feed, easily animal is damaged; (2) directly take herbal powder when raw material is prepared, due to the difference in the medicinal material place of production and season, cause the medicament contg in former medicine unstable, quality stability is poor, and the effective ingredient between product different batches differs greatly; (3) directly take herbal powder when raw material is prepared, crude drug cell institutional framework is fully broken, causes after animal edible non-digestiblely, has reduced the availability of medicine; (4) in addition, the greatest problem of prior art is to reach the compound proportion of optimum medicine efficacy because of composite more difficult definite its of Chinese medicine.
Given this, the Chinese herb feed additive with immunological enhancement of efficient, the low toxicity of development, low-residual become aquaculture development in the urgent need to.
Summary of the invention
For solving the problems of the technologies described above, the present invention proposes a kind of antibiotic-free, without agricultural chemicals, heavy-metal residual, obvious Chinese herbal feed additive of immunoenhancement result and preparation method thereof and the feed that contains this additive.
Technical scheme of the present invention is: Chinese herbal feed additive, it comprises component and each component shared percentage by weight in described additive is: astragalus polyose: 1%-30%, barrenwort saponin: 1%-20%, Fructus Ligustri Lucidi polysaccharide: 1%-20%, LBP-X 1%-20%, auxiliary material: 10%-60%.Preferred weight percent is: astragalus polyose: 10%-20%, barrenwort saponin: 10%-15%, Fructus Ligustri Lucidi polysaccharide: 10%-15%, LBP-X 10%-15%, auxiliary material: 30%-50%.Optimum percentage by weight is: astragalus polyose: 20%, and barrenwort saponin: 10%, Fructus Ligustri Lucidi polysaccharide: 15%, LBP-X: 15%, auxiliary material: 40%.
The preparation method of Chinese herbal feed additive of the present invention is: get astragalus polyose powder, barrenwort saponin powder, fruit of glossy privet powder, LBP-X powder and auxiliary material, add in mass ratio three-dimensional mixing machine fully to mix; The speed of agitator of three-dimensional mixing machine is 10-400 rev/min, and mixing time is 0.1-1 hour; Mix rear sealed packaging.Before compound additive packing, carry out quality inspection, according to every bag of 1000g, divide and install in aluminium foil bag after the assay was approved, sealing.
Auxiliary material main component of the present invention is starch, accounts for 90% of auxiliary material weight, and other composition is a-cyclodextrin and b-cyclodextrin.
The using method of Chinese herbal feed additive of the present invention is: direct spice or add in water and drink.
Add the animal feed of Chinese herbal feed additive of the present invention, described Chinese herbal feed additive shared percentage by weight in described animal feed is: 0.1%-1.2%.
Astragalus polyose is legume astragalus mongolicus or Astragalus membranaceus extract, rhamnose, arabinose, wood sugar, mannose, galactolipin and glucose etc., consists of, and has to regulate immune, antiviral, antitumor, anti-oxidant, radioresistance, resist and stress wait effect.Astragalus polyose has antagonism to immunodepressant, can significantly strengthen non-specific immune function and humoral immune function, and being mainly reflected in can Promote immunity allelotaxis.Astragalus polyose is mainly reflected in the impact on animal thymus, spleen and bursa of farbricius weight to the impact of animal immune organ; The viruses such as pig circular ring virus, CSFV are had to good therapeutic effect simultaneously.Research finds, astragalus polyose can the utmost point significantly improves the antibody horizontal of piglet hog cholera vaccine, significantly improves piglet peripheral blood neutrophil cell percentage and lymphocyte transformation rate, shows that astragalus polyose has certain facilitation to the immunologic function of piglet.Astragalus polyose, as a kind of green additive, enjoys favor in animal husbandry.
Icariine is the main component of Shorthorned Epimedium P.E, icariine has obvious regulating action to body immune system, can improve the immune level of immunocompromised mouse due to test, its mechanism is absolute quantity and the relative populations that icariine can increase splenocyte in spleen, improve the quantity (as t lymphocyte subset group, bone-marrow-derived lymphocyte etc. in spleen) of immune cell, and can excite the propagation of bone marrow nucleated cell, thereby performance immunoregulation effect.
Fructus Ligustri Lucidi polysaccharide is one of active ingredient of the fruit of glossy privet.It has raising immunity of organisms, promotes the phagocytic function of lymphopoiesis and macrophage.Fructus Ligustri Lucidi polysaccharide is relevant with the immune state of body to the immunization of mouse, and to non-specific cell, immunity has humidification, and the specific cellular immunity of normal mouse is not made significant difference, and the cellular immunity of immunosuppressive condition mouse is had to humidification.It strengthens immune main active is oleanolic acid, polysaccharide, volatilization wet goods.Fructus Ligustri Lucidi polysaccharide not only has the function that strengthens cellular immunity and humoral immunity, can also and improve the number of ways such as its gene expression and bring into play its immune enhancing function by short Cytokines Production.Therefore, Fructus Ligustri Lucidi polysaccharide substitute antibiotics and become feed addictive and there is good development prospect.
LBP-X is wolfberry fruit extract, mainly 6 kinds of monose such as arabinose, glucose, galactolipin, mannose, rhamnose and wood sugars, consists of.LBP-X can alleviate Insulin Resistance of Rats and reduce plasma TG, TC and body weight, increase the glucose transporter 4 on Skeletal Muscle Cell surface, improve transhipment and the insulin signaling level of glucose transporter 4 in cell, can also prevent the generation of animal diabetic nephropathy simultaneously.LBP-X also has the immunity of increasing, radioresistance, neuroprotection, reproductive system defencive function and liver protection etc. in addition.
Beneficial effect of the present invention is: according to traditional Chinese medicine theory, in conjunction with modern science and technology, independent research to extract astragalus polyose, barrenwort saponin, Fructus Ligustri Lucidi polysaccharide and LBP-X four taste traditional Chinese medicine monomer, be mainly the residual Chinese herbal feed additive of main pure natural, antibiotic-free, non agricultural chemical residuum and heavy metal free, overcome the shortcoming of Chinese traditional herbs feed addictive.The present invention utilizes three-dimensional mixing machine to mix, and spray-on process makes pulvis, quality controllable.
The specific embodiment
Below in conjunction with embodiment, illustrate the present invention.
Embodiment 1:
1, prepare Chinese herbal feed additive
(1) take 200kg astragalus polyose powder, 100kg barrenwort saponin powder, 150kg Fructus Ligustri Lucidi polysaccharide powder, 50kg LBP-X powder and auxiliary material 400kg; Astragalus polyose: 22.22%, barrenwort saponin: 11.11%, Fructus Ligustri Lucidi polysaccharide: 16.67%, LBP-X: 5.56%, auxiliary material: 44.44%.Astragalus polyose: barrenwort saponin: Fructus Ligustri Lucidi polysaccharide: LBP-X: auxiliary material=4:2:3:1:8
(2) above-mentioned 5 Raws are added in three-dimensional mixing machine to mix and blend 1 hour, rotating speed is: 20 revs/min.
(3) carry out quality inspection after mixing, according to 1000g, within every bag minute, install in aluminium foil bag after qualified, sealing, shady and cool dry place preserves.
2, pig is carried out to the test of pesticide effectiveness
(1) choose 60 healthy tri-crossbreedings of 30 ages in days, by Junan, animal husbandry Co., Ltd provides, and is divided at random two groups, organizes in the feed of 1 piglet and does not add any medicine, as blank group; Organize the Chinese medicine compound additive spice that adds respectively embodiment 1 preparation in 2 feeds by 1kg/t dosage, successive administration 7 days.Organize in 3 feeds and according to 1kg/t dosage, add folk prescription astragalus polyose powder respectively, successive administration 7 days.Organize in 4 feeds and according to 1kg/t dosage, add folk prescription barrenwort saponin powder, successive administration 7 days respectively.Organize in 5 feeds and according to 1kg/t dosage, add folk prescription Fructus Ligustri Lucidi polysaccharide powder respectively, successive administration 7 days.Organize in 6 feeds and according to 1kg/t dosage, add folk prescription LBP-X powder respectively, successive administration 7 days.
(2) swine fever virus resistant vaccine inoculation and antibody test:
Administration finishes the same day, 1 part of all piglet musculi colli injecting swine fever vaccines/only; Respectively at the immunity inoculation same day (0 week) and collection in the 1st, 3,5 weeks, respectively organize the vena cava anterior blood of piglet; Separation of serum, detects the anti-hog cholera antibody level in serum, and testing result is as shown in table 1.
Table 1 embodiment 1: the anti-hog cholera antibody level (ug/ml) of different time after immunity inoculation
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 1.44±0.33 | 2.32±0.22 | 3.56±0.30 | 5.76±0.28 |
| Group 2 | 1.54±0.30 | 3.98±0.32 | 5.30±0.27 | 7.12±0.31 |
| Group 3 | 1.43±0.31 | 2.93±0.12 | 4.16±0.29 | 6.46±0.28 |
| Group 4 | 1.45±0.23 | 3.21±0.32 | 4.06±0.29 | 6.06±0.18 |
| Group 5 | 1.46±0.33 | 2.92±0.13 | 4.26±0.30 | 5.76±0.28 |
| Group 6 | 1.44±0.34 | 3.32±0.22 | 4.16±0.30 | 5.86±0.18 |
According to table 1, can find out:
1) inoculate the same day (0 week), each anti-hog cholera antibody level of organizing piglet is lower, indifference between group;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet antibody horizontal that adds embodiment 1 compound additive in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
(3) impact on pig T lymphocyte quantity:
Administration finishes the same day, 1 part of all piglet musculi colli injecting swine fever vaccines/only; Respectively at the immunity inoculation same day (0 week) and collection in the 1st, 3,5 weeks, respectively organize the vena cava anterior blood of piglet; Get respectively control group and administration group pig blood sample is made blood film, for detection of T lymphocyte, testing result is as shown in table 2.
The measurement result of table 2 embodiment 1:T lymphocyte quantity ratio (%)
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 10.4±0.5 | 12.3±0.4 | 16.7±0.5 | 20.4±0.4 |
| Group 2 | 10.5±0.6 | 14.9±0.5 | 18.1±0.4 | 23.3±0.5 |
| Group 3 | 10.3±0.5 | 13.3±0.3 | 17.1±0.5 | 21.4±0.6 |
| Group 4 | 10.4±0.2 | 12.8±0.4 | 16.8±0.3 | 20.9±0.2 |
| Group 5 | 10.2±0.4 | 13.1±0.4 | 17.4±0.5 | 22.4±0.2 |
| Group 6 | 10.6±0.2 | 12.3±0.4 | 16.9±0.2 | 21.4±0.3 |
According to table 2, can find out:
1) inoculate the same day (0 week), each organizes the T lymphocyte quantity indifference of piglet;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet T lymphocyte quantity that adds embodiment 1 compound additive in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
3, chicken is carried out to the test of pesticide effectiveness
(1) choose the healthy Ai Wei mattress of 120 plumage 1 age in days broiler chicken, by Junan, animal husbandry Co., Ltd provides, and is divided at random six groups, organizes in the feed of 1 chick and does not add any medicine, as blank group; Organize the Chinese medicine compound additive spice that adds respectively embodiment 1 preparation in 2 feeds according to 0.8g/kg dosage, successive administration 30 days.Organize in 3 feeds and according to 0.8g/kg dosage, add folk prescription astragalus polyose powder respectively, successive administration 30 days.Organize in 4 feeds and according to 0.8g/kg dosage, add folk prescription barrenwort saponin powder, successive administration 30 days respectively.Organize in 5 feeds and according to 0.8g/kg dosage, add folk prescription Fructus Ligustri Lucidi polysaccharide powder respectively, successive administration 30 days.Organize in 6 feeds and according to 0.8g/kg dosage, add folk prescription LBP-X powder respectively, successive administration 30 days.
(2) anti-Newcastle virus vaccine inoculation and antibody test:
Administration the 8th day, 1 part of plumage of all chick intramuscular injection new city vaccines/only; Respectively at the immunity inoculation same day (0 day) and the 7th, 14,21 days, gather venous blood under the wing of respectively organizing chick; Separation of serum, detects the anti-Newcastle virus antibody horizontal in serum, and testing result is as shown in table 3.
Table 3 embodiment 1: the anti-Newcastle virus antibody horizontal (ug/ml) of different time after immunity inoculation
| Group | 0 day | 7 days | 14 days | 21 days |
| Group 1 | 1.04±0.23 | 1.72±0.22 | 2.76±0.19 | 4.86±0.21 |
| Group 2 | 1.05±0.24 | 3.18±0.18 | 4.81±0.26 | 6.72±0.20 |
| Group 3 | 1.14±0.21 | 2.12±0.12 | 3.26±0.18 | 5.16±0.20 |
| Group 4 | 1.07±0.17 | 2.22±0.21 | 3.16±0.19 | 5.86±0.21 |
| Group 5 | 1.09±0.21 | 2.17±0.22 | 3.06±0.20 | 5.09±0.19 |
| Group 6 | 1.04±0.23 | 2.33±0.23 | 3.36±0.18 | 5.76±0.21 |
According to table 3, can find out:
1) inoculate the same day (0 day), each anti-Newcastle virus antibody horizontal of organizing chick is lower, indifference between group;
2) inoculation is latter the 7th, 14,21 days, and the chick antibody horizontal that adds embodiment 1 compound additive in feed does not add the chick of additivated chick and folk prescription medicated premix apparently higher than blank group.
(3) impact on chicken body weight:
Chick to all groups, on original administration basis of 30 days, then successive administration 5 days.
From administration the 1st day, week about every group of chick weighed to a body weight, consecutive weighings 5 weeks; Weighing results is as shown in table 4.
Table 4 embodiment 1: each organizes chick changes of weight (* 10g)
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks | 5 weeks |
| Group 1 | 6.1±0.5 | 16.2±1.4 | 25.1±2.3 | 50.1±2.4 | 80.3±2.7 | 120.2±3.3 |
| Group 2 | 6.2±0.3 | 18.3±1.5 | 34.3±3.4 | 60.2±1.8 | 95.5±2.5 | 130.1±2.1 |
| Group 3 | 6.3±0.4 | 17.3±1.4 | 26.9±1.5 | 52.1±3.5 | 84.4±1.7 | 124.3±2.6 |
| Group 4 | 6.2±0.4 | 16.6±1.7 | 27.1±2.2 | 53.3±2.5 | 86.7±3.7 | 126.4±2.4 |
| Group 5 | 6.1±0.3 | 16.8±1.4 | 28.1±1.7 | 52.7±2.5 | 85.6±2.3 | 128.4±3.3 |
| Group 6 | 6.2±0.6 | 16.4±1.4 | 29.0±2.2 | 53.9±1.5 | 86.6±1.9 | 124.3±2.3 |
According to table 4, can find out:
1) the administration same day (0 day), each organizes chick body weight no difference of science of statistics;
2) in 1-5 week after administration, in feed, add the chick body weight of embodiment 1 compound additive and apparently higher than blank group, do not add the chick of additivated chick and folk prescription medicated premix.
(4) impact on Immune Organs of Chicken spleen:
Administration the 2nd week, 1 part of plumage of all chick intramuscular injection new city vaccines/only; Respectively at the immunity inoculation same day (0 week) and the 1st, 2,3,4 weeks, from group 1-, organize 6 every groups respectively at every turn and get 4 of chick, after slaughtering, get spleen and weigh, calculate index and spleen index; Index and spleen index=thymic weight (g)/body weight (kg).Testing result is as shown in table 5.
Table 5 embodiment 1: each organizes the index and spleen index of chick
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Group 1 | 0.61±0.05 | 0.74±0.10 | 0.80±0.06 | 0.95±0.05 | 1.08±0.05 |
| Group 2 | 0.61±0.04 | 0.80±0.09 | 0.93±0.07 | 1.16±0.04 | 1.33±0.02 |
| Group 3 | 0.62±0.03 | 0.75±0.11 | 0.85±0.06 | 1.04±0.05 | 1.18±0.03 |
| Group 4 | 0.62±0.02 | 0.75±0.13 | 0.88±0.04 | 1.05±0.03 | 1.28±0.03 |
| Group 5 | 0.61±0.01 | 0.76±0.10 | 0.82±0.07 | 1.09±0.03 | 1.11±0.05 |
| Group 6 | 0.60±0.02 | 0.77±0.13 | 0.84±0.03 | 0.99±0.02 | 1.12±0.03 |
According to table 5, can find out:
1) inoculation same day (0 week), each organizes indifference between the index and spleen index group of chick;
2) inoculation is latter the 1st, 2,3,4 weeks, adds the chick index and spleen index of embodiment 1 compound additive and apparently higher than control group, do not add the chick of additivated chick and folk prescription medicated premix in feed.
(5) impact in challenge test on chicken
A, again choose the healthy Ai Wei mattress of 120 plumage 1 age in days broiler chicken, by Junan, animal husbandry Co., Ltd provides, and is divided at random six groups, organizes in the feed of 1 chick and does not add any medicine, as blank group; Organize the Chinese medicine compound additive spice that adds respectively embodiment 1 preparation in 2 feeds according to 0.8g/kg dosage, organize in 3 feeds and according to 0.8g/kg dosage, add folk prescription astragalus polyose powder respectively, organize in 4 feeds and according to 0.8g/kg dosage, add folk prescription barrenwort saponin powder respectively, organize in 5 feeds and according to 0.8g/kg dosage, add folk prescription Fructus Ligustri Lucidi polysaccharide powder respectively, organize in 6 feeds and according to 0.8g/kg dosage, add folk prescription LBP-X powder respectively.Group 2-organizes 6 discontinuity administrations, i.e. first administration 3 days, and drug withdrawal is after 3 days, then administration 3 days, then drug withdrawal 3 days; Feed continuously in this way 30 days.
B, the 31st day time, give all chick, the full viral disease strain of intramuscular inoculation Newcastle virus, observe every day, and record the dead quantity of chick; Continuous Observation 1 week; The chick that dies of illness carries out burning disposal at any time; After experiment finishes, all inoculation chick are all slaughtered and burn.The dead result of challenge test chick is as shown in table 6.
Table 6 embodiment 1: the challenge test chick death rate
| Group | Sum | Survival number | Death toll | The death rate |
| Group 1 | 20 | 2 | 18 | 90% |
| Group 2 | 20 | 15 | 5 | 25% |
| Group 3 | 20 | 8 | 12 | 60% |
| Group 4 | 20 | 10 | 10 | 50% |
| Group 5 | 20 | 7 | 13 | 65% |
| Group 6 | 20 | 7 | 13 | 65% |
According to table 6, can find out:
Inoculating the 1st day, there is the phenomenon of dying of illness in blank group Chickens, and the chicken ratio of dying of illness after a week surpasses 90%; The death rate of the group of single preparations of ephedrine also, more than 50%, only has 25% and organize 2 chick case fatality rate.Illustrate that embodiment 1 compound additive can effectively improve the immunity of chick, reduce the Chickens Infected Newcastle virus death rate.
Embodiment 2:
Outside lower difference, other are with embodiment 1.
1, prepare Chinese herbal feed additive
(1) take 100kg astragalus polyose powder, 150kg barrenwort saponin powder, 100kg Fructus Ligustri Lucidi polysaccharide powder, 100kg LBP-X powder and auxiliary material 400kg; Astragalus polyose: 11.76%, barrenwort saponin: 17.64%, Fructus Ligustri Lucidi polysaccharide: 11.76%, LBP-X: 11.76%, auxiliary material: 47.06%.Astragalus polyose: barrenwort saponin: Fructus Ligustri Lucidi polysaccharide: LBP-X: auxiliary material=2:3:2:2:8
(2) above-mentioned 5 Raws are added in three-dimensional mixing machine to mix and blend 1 hour, rotating speed is: 30 revs/min
(3) carry out quality inspection after mixing, according to 1000g, within every bag minute, install in aluminium foil bag after qualified, sealing, shady and cool dry place preserves.
2, pig is carried out to the test of pesticide effectiveness
(2) swine fever virus resistant vaccine inoculation and antibody test: testing result is as shown in table 7.
Table 7 embodiment 2: the anti-hog cholera antibody level (ug/ml) of different time after immunity inoculation
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 1.34±0.31 | 2.22±0.21 | 3.55±0.20 | 5.36±0.18 |
| Group 2 | 1.35±0.31 | 3.88±0.32 | 5.32±0.27 | 7.21±0.21 |
| Group 3 | 1.32±0.21 | 2.73±0.11 | 4.36±0.27 | 6.26±0.08 |
| Group 4 | 1.33±0.21 | 3.27±0.22 | 4.26±0.28 | 6.26±0.18 |
| Group 5 | 1.36±0.13 | 2.98±0.13 | 4.36±0.31 | 5.16±0.18 |
| Group 6 | 1.34±0.24 | 3.22±0.21 | 4.70±0.30 | 7.01±0.19 |
According to table 7, can find out:
1) inoculate the same day (0 week), each anti-hog cholera antibody level of organizing piglet is lower, indifference between group;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet antibody horizontal that adds embodiment 2 compound additives in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
(3) impact on pig T lymphocyte quantity: testing result is as shown in table 8.
The measurement result of table 8 embodiment 2:T lymphocyte quantity ratio (%)
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 10.4±0.3 | 12.5±0.4 | 17.7±0.5 | 21.4±0.4 |
| Group 2 | 10.6±0.5 | 15.2±0.2 | 18.3±0.4 | 24.3±0.5 |
| Group 3 | 10.4±0.3 | 13.2±0.1 | 17.2±0.3 | 20.4±0.2 |
| Group 4 | 10.5±0.2 | 12.7±0.4 | 17.1±0.3 | 20.3±0.2 |
| Group 5 | 10.2±0.4 | 13.2±0.4 | 17.4±0.5 | 20.4±0.2 |
| Group 6 | 10.4±0.2 | 12.4±0.4 | 16.8±0.2 | 21.4±0.3 |
According to table 8, can find out:
1) inoculate the same day (0 week), each organizes the T lymphocyte quantity indifference of piglet;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet T lymphocyte quantity that adds embodiment 2 compound additives in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
3, chicken is carried out to the test of pesticide effectiveness
(2) anti-Newcastle virus vaccine inoculation and antibody test: testing result is as shown in table 9.
Table 9 embodiment 2: the anti-Newcastle virus antibody horizontal (ug/ml) of different time after immunity inoculation
| Group | 0 day | 7 days | 14 days | 21 days |
| Group 1 | 1.03±0.23 | 1.74±0.22 | 2.66±0.19 | 4.96±0.21 |
| Group 2 | 1.04±0.22 | 3.20±0.18 | 4.82±0.21 | 6.74±0.21 |
| Group 3 | 1.04±0.21 | 2.32±0.12 | 3.26±0.19 | 5.26±0.20 |
| Group 4 | 1.06±0.17 | 2.32±0.11 | 3.26±0.19 | 5.76±0.19 |
| Group 5 | 1.05±0.19 | 2.37±0.22 | 3.16±0.20 | 5.19±0.19 |
| Group 6 | 1.04±0.12 | 2.43±0.21 | 3.46±0.18 | 5.66±0.21 |
According to table 9, can find out:
1) inoculate the same day (0 day), each anti-Newcastle virus antibody horizontal of organizing chick is lower, indifference between group;
2) inoculation is latter the 7th, 14,21 days, and the chick antibody horizontal that adds embodiment 2 compound additives in feed does not add the chick of additivated chick and folk prescription medicated premix apparently higher than blank group.
(3) impact on chicken body weight: weighing results is as shown in table 10.
Table 10 embodiment 2: each organizes chick changes of weight (* 10g)
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks | 5 weeks |
| Group 1 | 6.2±0.3 | 16.3±1.1 | 24.1±1.3 | 51.1±2.1 | 81.3±2.1 | 119.2±2.5 |
| Group 2 | 6.1±0.3 | 19.3±1.1 | 32.3±1.4 | 61.2±1.8 | 92.5±2.3 | 129.1±2.2 |
| Group 3 | 6.3±0.2 | 18.3±1.4 | 24.9±1.5 | 53.1±1.5 | 85.4±1.9 | 129.3±2.1 |
| Group 4 | 6.2±0.3 | 17.6±1.1 | 25.1±2.2 | 54.3±2.5 | 82.7±1.7 | 121.4±2.4 |
| Group 5 | 6.1±0.3 | 17.2±1.2 | 26.1±1.1 | 52.7±1.7 | 84.6±2.3 | 127.4±2.3 |
| Group 6 | 6.1±0.4 | 17.4±1.3 | 28.3±1.2 | 52.9±1.8 | 85.6±2.0 | 124.3±2.3 |
According to table 10, can find out:
1) the administration same day (0 day), each organizes chick body weight no difference of science of statistics;
2) in 1-5 week after administration, in feed, add the chick body weight of embodiment 2 compound additives and apparently higher than blank group, do not add the chick of additivated chick and folk prescription medicated premix.
(4) impact on Immune Organs of Chicken spleen: testing result is as shown in table 11.
Table 11 embodiment 2: each organizes the index and spleen index of chick
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Group 1 | 0.63±0.03 | 0.68±0.10 | 0.81±0.06 | 0.97±0.05 | 1.07±0.05 |
| Group 2 | 0.62±0.04 | 0.80±0.11 | 0.94±0.11 | 1.18±0.04 | 1.23±0.03 |
| Group 3 | 0.62±0.04 | 0.71±0.11 | 0.85±0.06 | 1.14±0.05 | 1.19±0.03 |
| Group 4 | 0.63±0.03 | 0.73±0.13 | 0.88±0.04 | 1.15±0.03 | 1.28±0.04 |
| Group 5 | 0.62±0.03 | 0.76±0.10 | 0.82±0.07 | 1.10±0.03 | 1.11±0.05 |
| Group 6 | 0.61±0.04 | 0.77±0.13 | 0.84±0.13 | 1.09±0.02 | 1.12±0.03 |
According to table 11, can find out:
1) inoculation same day (0 week), each organizes indifference between the index and spleen index group of chick;
2) inoculation is latter the 1st, 2,3,4 weeks, adds the chick index and spleen index of embodiment 2 compound additives and apparently higher than control group, do not add the chick of additivated chick and folk prescription medicated premix in feed.
(5) impact in challenge test on chicken: the dead result of challenge test chick is as shown in table 12.
Table 12 embodiment 2: the challenge test chick death rate
| Group | Sum | Survival number | Death toll | The death rate |
| Group 1 | 20 | 3 | 17 | 85% |
| Group 2 | 20 | 14 | 6 | 30% |
| Group 3 | 20 | 10 | 10 | 50% |
| Group 4 | 20 | 11 | 9 | 45% |
| Group 5 | 20 | 8 | 12 | 60% |
| Group 6 | 20 | 7 | 13 | 65% |
According to table 12, can find out:
Inoculating the 1st day, there is the phenomenon of dying of illness in blank group Chickens, and the chicken ratio of dying of illness after a week surpasses 85%; The death rate of the group of single preparations of ephedrine also, more than 50%, only has 30% and organize 2 chick case fatality rate.Illustrate that embodiment 2 compound additives can effectively improve the immunity of chick, reduce the Chickens Infected Newcastle virus death rate.
Embodiment 3:
Outside lower difference, other are with embodiment 1.
1, prepare Chinese herbal feed additive
(1) take 150kg astragalus polyose powder, 120kg barrenwort saponin powder, 90kg Fructus Ligustri Lucidi polysaccharide powder, 60kg LBP-X powder and auxiliary material 270kg; Astragalus polyose: 21.74%, barrenwort saponin: 17.39%, Fructus Ligustri Lucidi polysaccharide: 13.06%, LBP-X: 8.69%, auxiliary material: 39.13%.Astragalus polyose: barrenwort saponin: Fructus Ligustri Lucidi polysaccharide: LBP-X: auxiliary material=5:4:3:2:9
(2) above-mentioned 5 Raws are added in three-dimensional mixing machine to mix and blend 1 hour, rotating speed is: 40 revs/min.
(3) carry out quality inspection after mixing, according to 1000g, within every bag minute, install in aluminium foil bag after qualified, sealing, shady and cool dry place preserves.
2, pig is carried out to the test of pesticide effectiveness
(2) swine fever virus resistant vaccine inoculation and antibody test: testing result is as shown in table 13.
Table 13 embodiment 3: the anti-hog cholera antibody level (ug/ml) of different time after immunity inoculation
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 1.33±0.21 | 2.12±0.22 | 3.45±0.21 | 5.46±0.28 |
| Group 2 | 1.32±0.21 | 3.98±0.32 | 5.22±0.27 | 7.22±0.21 |
| Group 3 | 1.34±0.21 | 2.73±0.11 | 4.36±0.27 | 6.26±0.08 |
| Group 4 | 1.35±0.13 | 2.98±0.13 | 4.36±0.31 | 5.16±0.18 |
| Group 5 | 1.34±0.24 | 3.22±0.21 | 4.70±0.30 | 7.01±0.19 |
| Group 6 | 1.33±0.21 | 3.27±0.22 | 4.26±0.28 | 6.26±0.18 |
According to table 13, can find out:
1) inoculate the same day (0 week), each anti-hog cholera antibody level of organizing piglet is lower, indifference between group;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet antibody horizontal that adds embodiment 3 compound additives in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
(3) impact on pig T lymphocyte quantity: testing result is as shown in 14.
The measurement result of table 14 embodiment 3:T lymphocyte quantity ratio (%)
| Group | 0 week | 1 week | 3 weeks | 5 weeks |
| Group 1 | 10.5±0.4 | 12.6±0.3 | 17.8±0.5 | 19.9±0.4 |
| Group 2 | 10.6±0.5 | 15.2±0.2 | 18.3±0.4 | 24.3±0.5 |
| Group 3 | 10.4±0.2 | 12.4±0.4 | 16.8±0.2 | 21.4±0.3 |
| Group 4 | 10.4±0.3 | 13.2±0.1 | 17.2±0.3 | 22.4±0.2 |
| Group 5 | 10.2±0.4 | 13.2±0.4 | 17.4±0.5 | 21.4±0.2 |
| Group 6 | 10.5±0.2 | 12.7±0.4 | 17.1±0.3 | 21.3±0.2 |
According to table 14, can find out:
1) inoculate the same day (0 week), each organizes the T lymphocyte quantity indifference of piglet;
2) inoculation is latter the 1st, 3,5 weeks, and the piglet T lymphocyte quantity that adds embodiment 3 compound additives in feed does not add the piglet of additivated piglet and folk prescription medicated premix apparently higher than control group.
3, chicken is carried out to the test of pesticide effectiveness
(2) anti-Newcastle virus vaccine inoculation and antibody test: testing result is as shown in Table 15.
Table 15 embodiment 3: the anti-Newcastle virus antibody horizontal (ug/ml) of different time after immunity inoculation
| Group | 0 day | 7 days | 14 days | 21 days |
| Group 1 | 1.04±0.21 | 1.84±0.21 | 2.76±0.18 | 4.86±0.20 |
| Group 2 | 1.05±0.20 | 3.21±0.18 | 4.81±0.21 | 6.73±0.20 |
| Group 3 | 1.05±0.19 | 2.37±0.22 | 3.16±0.20 | 5.19±0.19 |
| Group 4 | 1.04±0.12 | 2.43±0.21 | 3.46±0.18 | 5.66±0.21 |
| Group 5 | 1.06±0.17 | 2.32±0.11 | 3.26±0.19 | 5.76±0.19 |
| Group 6 | 1.04±0.21 | 2.32±0.12 | 3.26±0.19 | 5.26±0.20 |
According to table 15, can find out:
1) inoculate the same day (0 day), each anti-Newcastle virus antibody horizontal of organizing chick is lower, indifference between group;
2) inoculation is latter the 7th, 14,21 days, and the chick antibody horizontal that adds embodiment 3 compound additives in feed does not add the chick of additivated chick and folk prescription medicated premix apparently higher than blank group.
(3) impact on chicken body weight: weighing results is shown in table 16.
Table 16 embodiment 3: each organizes chick changes of weight (* 10g)
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks | 5 weeks |
| Group 1 | 6.2±0.2 | 17.1±1.2 | 25.1±1.3 | 52.1±1.1 | 82.3±2.1 | 118.2±2.3 |
| Group 2 | 6.3±0.3 | 20.3±1.1 | 31.3±1.4 | 62.2±1.8 | 91.5±2.3 | 130.1±2.2 |
| Group 3 | 6.1±0.4 | 17.4±1.3 | 28.3±1.2 | 52.9±1.8 | 85.6±2.0 | 124.3±2.3 |
| Group 4 | 6.1±0.3 | 17.2±1.2 | 26.1±1.1 | 52.7±1.7 | 84.6±2.3 | 127.4±2.3 |
| Group 5 | 6.3±0.2 | 18.3±1.4 | 24.9±1.5 | 53.1±1.5 | 85.4±1.9 | 129.3±2.1 |
| Group 6 | 6.2±0.3 | 17.6±1.1 | 25.1±2.2 | 54.3±2.5 | 82.7±1.7 | 121.4±2.4 |
According to table 16, can find out:
1) the administration same day (0 day), each organizes chick body weight no difference of science of statistics;
2) in 1-5 week after administration, in feed, add the chick body weight of embodiment 3 compound additives and apparently higher than blank group, do not add the chick of additivated chick and folk prescription medicated premix.
(4) impact on Immune Organs of Chicken spleen: testing result is shown in table 17.
Table 17 embodiment 3: each organizes the index and spleen index of chick
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Group 1 | 0.63±0.03 | 0.68±0.10 | 0.81±0.06 | 0.97±0.05 | 1.07±0.05 |
| Group 2 | 0.62±0.04 | 0.80±0.11 | 0.94±0.11 | 1.18±0.04 | 1.23±0.03 |
| Group 3 | 0.62±0.03 | 0.76±0.10 | 0.82±0.07 | 1.10±0.03 | 1.11±0.05 |
| Group 4 | 0.61±0.04 | 0.77±0.13 | 0.84±0.13 | 1.09±0.02 | 1.12±0.03 |
| Group 5 | 0.63±0.03 | 0.73±0.13 | 0.88±0.04 | 1.15±0.03 | 1.28±0.04 |
| Group 6 | 0.62±0.04 | 0.71±0.11 | 0.85±0.06 | 1.14±0.05 | 1.19±0.03 |
According to table 17, can find out:
1) inoculation same day (0 week), each organizes indifference between the index and spleen index group of chick;
2) inoculation is latter the 1st, 2,3,4 weeks, adds the chick index and spleen index of embodiment 3 compound additives and apparently higher than control group, do not add the chick of additivated chick and folk prescription medicated premix in feed.
(5) impact in challenge test on chicken: the dead result of challenge test chick is shown in table 18.
Table 18 embodiment 3: the challenge test chick death rate
| Group | Sum | Survival number | Death toll | The death rate |
| Group 1 | 20 | 3 | 17 | 85% |
| Group 2 | 20 | 17 | 3 | 15% |
| Group 3 | 20 | 7 | 13 | 65% |
| Group 4 | 20 | 8 | 12 | 60% |
| Group 5 | 20 | 11 | 9 | 45% |
| Group 6 | 20 | 10 | 10 | 50% |
According to table 18, can find out:
Inoculating the 1st day, there is the phenomenon of dying of illness in blank group Chickens, and the chicken ratio of dying of illness after a week surpasses 85%; The death rate of the group of single preparations of ephedrine also, more than 45%, only has 15% and organize 2 chick case fatality rate.Illustrate that embodiment 3 compound additives can effectively improve the immunity of chick, reduce the Chickens Infected Newcastle virus death rate.
Claims (7)
1. a Chinese herbal feed additive, is characterized in that, comprises component and each component shared percentage by weight in described additive to be: astragalus polyose: 1%-30%, barrenwort saponin: 1%-20%, Fructus Ligustri Lucidi polysaccharide: 1%-20%, LBP-X 1%-20%, auxiliary material: 10%-60%.
2. Chinese herbal feed additive according to claim 1, it is characterized in that, comprising component and each component shared percentage by weight in described additive is: astragalus polyose: 10%-25%, barrenwort saponin: 10%-20%, Fructus Ligustri Lucidi polysaccharide: 10%-15%, LBP-X 5%-10%, auxiliary material: 30%-50%.
3. Chinese herbal feed additive according to claim 1, it is characterized in that, comprising component and each component shared percentage by weight in described additive is: astragalus polyose: 21.74%, barrenwort saponin: 17.39%, Fructus Ligustri Lucidi polysaccharide: 13.06%, LBP-X: 8.69%, auxiliary material: 39.13%.
4. according to the Chinese herbal feed additive described in any one in claim 1-3, it is characterized in that, described auxiliary material main component is starch, accounts for 90% of auxiliary material weight, and other composition is a-cyclodextrin and b-cyclodextrin.
5. according to the Chinese herbal feed additive described in any one in claim 1-3, its preparation method is: get astragalus polyose powder, barrenwort saponin powder, fruit of glossy privet powder, LBP-X powder and auxiliary material, add in mass ratio three-dimensional mixing machine fully to mix; The speed of agitator of three-dimensional mixing machine is 10-400 rev/min, and mixing time is 0.1-1 hour; Mix rear sealed packaging.
6. the preparation method of Chinese herbal feed additive according to claim 5, is characterized in that: described auxiliary material main component is starch, accounts for 90% of auxiliary material weight, and other composition is a-cyclodextrin and b-cyclodextrin.
7. interpolation, according to an animal feed for Chinese herbal feed additive described in any one in claim 1-4, is characterized in that, described Chinese herbal feed additive shared percentage by weight in described animal feed is: 0.1%-1.2%.
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