CN103652442B - Feed additive for improving growth immune function of broilers, preparation method and application - Google Patents
Feed additive for improving growth immune function of broilers, preparation method and application Download PDFInfo
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Abstract
The invention discloses a feed additive for improving growth immune function of broilers, and the feed additive includes astragalus, folium isatidis, herba leonuri, hawthorn, malt, medicated leaven, pine needle powder, gastrodia armillaria mellea powder and a carrier. The invention also provides a preparation method and an application method of the feed additive. A variety of Chinese herbal medicines and the gastrodia armillaria mellea are used as main raw materials for preparing the feed additive to realize the coordination linkage of the Chinese herbal medicines and the gastrodia armillaria mellea, the broiler daily feed intake and daily weight gain are significantly increased, the mortality and the feed conversion ratio are decreased significantly and the broiler immunity (including immune organ indexes, hemagglutination inhibition antibody titer, peripheral lymphocyte transformation rate, NK (natural killer) cell activity, IL (interleukin) activity indexes) is significantly enhanced.
Description
Technical field
The invention belongs to field of feed additive technology, specifically relate to a kind of improve growth of meat chicken immune performance feed addictive, preparation method and application.
Background technology
Along with the development of herding intensive culture production model, the factors such as feeding environment worsens, nutrient is unbalanced or not enough, result in animal immunizing power low, show as poor growth, feedstuff-meat ratio rises, and the death rate raises, raiser is lost, and then affects livestock products market supply.Meanwhile, intensive lower stress effect, makes Animal performance be restlessness, this be stress external manifestation, in order to resisting stress, animals consuming a large number of nutrients for balancing various metabolism, its feeding achievement reduce.Production need the product that is suitable for and technology solve above two hang-ups.
Undeniable, in the past few decades, antibiotic is preventing and treating Animal diseases as feed addictive, improves breeding performonce fo animals aspect and serves positive role.But the Long-Time Service of antibiotics additive, causes many adverse consequences, makes germ create drug resistance, and then remaining influence in livestock products is to the health of people.For this reason, developed country has carried out strict restriction to antibiotic usage, and within 2006, European Union forbids fodder antibiotics comprehensively.The new feed addictive management rules of China have also made strict regulations to the use of Antibiotic Additive.
Therefore, Antistress agent is exempted from the increasing of the safety of development of new, is to overcome in Production of Livestock and Poultry process occur hypoimmunity, raising Safety of Livestock Products ' Quality and overcome the optimal path that stress wait problem.Current Animal nutrition scholar, at searching natural active matter, substitutes the production performance that antibiotic improves animal.Mainly have developed the multiple additives such as probiotic, oligosaccharides, plant extracts, Chinese herbal medicine both at home and abroad, to raising premunition, promote that production performance performance has certain effect, but effect does not have breakthrough progress.Publication number is that the one that application discloses of CN1788779A raises body-strengthening conditioning agent for fowl, this conditioning agent selects prepared from traditional Chinese medicines to form, and includes folium isatidis, golden cypress, the root of large-flowered skullcap, garlic, Radix Isatidis, raw hawthorn, the Radix Astragali, cactus, the bark of ash, radix pseudostellariae, the capsule of weeping forsythia, ginseng, the leaf of bamboo, raw Radix Glycyrrhizae, Fructus Hordei Germinatus, dried orange peel, honeysuckle, dark plum, motherwort.19 kinds of traditional Chinese medicinal components are comprised in the document, Chinese medicine cost is higher, although improve kind of adult livability and laying rate to a certain extent, but it is not obvious for the raising of the immunity (comprising Immune Organs Index, HI antibody titer, periphery lymphocyte conversion ratio, NK cytoactive, IL activity index) improving the broiler chicken later stage, and feedstuff-meat ratio is higher, the demand of existing feeding of broiler producer cannot be met.
We, while having accepted multinomial provinces and cities scientific research project, are devoted in the research of polysaccharide always, especially on fungi polysaccharide and bacterial polysaccharides, because they can carry out suitability for industrialized production by fermentation, cost is controlled, and environmental protection pressure is little, there is not the problem of resource shortage.Primary Study finds, add armillaria mellea accreting with Rhizoma Gastrodiae powder (main component is armillaria mellea polysaccharide, has other several functions product concurrently) and piglet skin can be made ruddy glossy, show as peace and quiet, feed conversion rate improves, and the incidence of disease and expenses for medicine decline.Be used as the research of feed addictive in early days at Chinese herbal medicine in conjunction with us, comprise and improve the calm Chinese medicine preparation of immunity and process technology (cellular level pulverizing technology), can further investigate as supporting technology, form brand-new increasing and exempt from Antistress agent, be expected to solve the above-mentioned difficult problem in producing.Look into new confirmation through Ministry of Education's current awareness search work station (Z09), armillaria mellea accreting with Rhizoma Gastrodiae powder is used as the research of feed addictive both at home and abroad and has no report, the research that armillaria mellea accreting with Rhizoma Gastrodiae powder and Chinese herbal medicine combination are used as feed addictive also has no report.
Summary of the invention
The invention provides a kind of feed addictive improving growth of meat chicken immune performance, this additive adopts multiple Chinese herbal medicine and armillaria mellea accreting with Rhizoma Gastrodiae to be that primary raw material prepares, and can significantly improve broiler production and immune performance.
Present invention also offers a kind of preparation method of feed addictive of above-mentioned raising growth of meat chicken immune performance, transformation of the way Preparation Method technique is simple, can be suitable for suitability for industrialized production.
Present invention also offers a kind of application process of feed addictive of above-mentioned raising growth of meat chicken immune performance, in application process, can make broiler chicken daily ingestion amount, daily gain significantly improves, the death rate and feedstuff-meat ratio significantly decline; Immunity of meat chickens significantly strengthens.
Improve a feed addictive for growth of meat chicken immune performance, comprising: the Radix Astragali, folium isatidis, motherwort, hawthorn, Fructus Hordei Germinatus, Divine Comedy, pine needle meal, armillaria mellea accreting with Rhizoma Gastrodiae powder and carrier.
As preferably, calculate according to percentage by weight, the feed addictive of described raising growth of meat chicken immune performance comprises:
As preferred further, calculate according to percentage by weight, the feed addictive of described raising growth of meat chicken immune performance comprises:
Described carrier is generally zeolite powder, also can select drug carrier in other as required.
In above-mentioned each traditional Chinese medicinal components:
The Radix Astragali: slightly warm in nature, taste is sweet, returns lung, spleen, liver, kidney channel, there is enhanced machine body immunity function, protect the liver, diuresis, anti-ageing, resisting stress, step-down and effect antibacterial widely, be used for the treatment of night sweat due to yin deficiency, syndrome of deficiency of lung qi, hidrosis edema.
Folium isatidis: cold in nature, bitter, returns liver, the heart, stomach warp, has heat-clearing, removing toxic substances, cool blood, effect of hemostasis, is used for the treatment of heat poison and sends out the diseases such as spot, erysipelas, abscess of throat, aphthae, sore and toxic.
Motherwort: cool in nature, bitter, the thoughts of returning home, liver, urinary bladder channel.Have invigorate blood circulation, silt of dispelling, menstruation regulating, the water that disappears effect, be used for the treatment of irregular menstruation, threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood at hematuria, and carbuncle swells sore.
Hawthorn: slightly warm in nature, taste acid, sweet, return spleen, stomach, Liver Channel, have promoting digestion and removing indigestion, effect of promoting blood circulation to remove blood stasis, cure mainly carnivorous stagnant, stomachache is had loose bowels, postpartum stasis blocking, hernia pain.
Fructus Hordei Germinatus: property is put down, and taste is sweet, return spleen, stomach warp, Liver Channel, have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn dissipate-swelling, cure mainly dyspepsia and do not disappear, abdominal distention, insufficiency of the spleen food is few, and newborn sweat smoulders, swollen breasts, and women weans.
Divine Comedy: warm in nature, bitter, returns spleen, stomach, large intestine channel, has reinforcing spleen to promote digestion, regulating QI to expel dampness, and the effect of inducing sweat, cures mainly the feeling of stuffiness in chest of getting ill from overeating, and stomachache is vomited and diarrhoea, dysentery, cold headache, and children's hinders hungry mistake and satisfies.
Pine needle meal: be processed into by the leaf of masson pine, Pinus taiwanesis, black pine, Japanese red pine, larch, Chinese pine, pinus sylvestris var. mongolica, dragon spruce and fir, containing abundant thick protein, fat, trace element and vitamin etc.
Above-mentioned Chinese medicine all can be selected from commercially available prod.
Present invention also offers the method for the feed addictive preparing above-mentioned raising growth of meat chicken immune performance, comprising:
(1) required Chinese medicine is got, section, mixing, mixed mixture is carried out coarse crushing, then carry out cellular level pulverizing, it is 25 ~ 40 microns (about fineness is 350 ~ 500 orders) that mixture is crushed to average grain diameter, then adds Part I carrier, mix, obtain sub-micron Chinese herbal medicine;
(2) the sub-micron Chinese herbal medicine obtained and armillaria mellea accreting with Rhizoma Gastrodiae powder are mixed, then add Part II carrier, mix and obtain feed addictive.
In step (1), coarse crushing can adopt existing equipment, about general corase grind to 60 orders.Carry out cellular level pulverizing and generally adopt QYF type fluidized bed air flow crusher.It is zeolite powder about 100 orders that the carrier adopted is generally fineness.
Armillaria mellea accreting with Rhizoma Gastrodiae powder derives from Zhejiang pharmaceutical Co. Ltd of Wan Feng group fermenting and producing, and this product is commercially sold.
The invention provides a kind of application process of feed addictive of above-mentioned raising growth of meat chicken immune performance, this feed addictive is when reality uses, and addition is the 0.1-0.5% of feed relative.Further preferred addition is the 0.1-0.3% of feed relative, more more preferably 0.2%.
Compared with prior art, beneficial effect of the present invention is embodied in:
It is that primary raw material prepares feed addictive that the present invention adopts multiple Chinese herbal medicine and armillaria mellea accreting with Rhizoma Gastrodiae, realize the coordination linkage of Chinese herbal medicine and armillaria mellea accreting with Rhizoma Gastrodiae, broiler chicken daily ingestion amount and daily gain can be made to significantly improve, and feedstuff-meat ratio significantly declines, immunity significantly strengthens, and without any harmful effect.
Detailed description of the invention
Embodiment 1
Respectively by the Radix Astragali, folium isatidis (leaf of Radix Isatidis), motherwort, hawthorn, Fructus Hordei Germinatus, Divine Comedy, pine needle meal is dried, then the Radix Astragali 200 grams is weighed respectively, folium isatidis (leaf of Radix Isatidis) 200 grams, motherwort 100 grams, hawthorn 50 grams, 50 grams, Fructus Hordei Germinatus, Divine Comedy 50 grams, pine needle meal 150 grams, then to cut into slices arrangement, mixing, first mixed mixture is carried out 60 order coarse crushings, then QYF type fluidized bed air flow crusher is adopted to carry out cellular level pulverizing, it is 25 ~ 40 microns (about fineness is 350 ~ 500 orders) that mixture is crushed to average grain diameter, add carrier zeolite powder 200 grams (fineness is 100 orders) again, total amount reaches 1000 grams, again mix, namely this sub-micron Chinese herbal medicine is obtained.
Mixed with 250 grams of armillaria mellea accreting with Rhizoma Gastrodiae powder by above-mentioned 500 grams of sub-micron Chinese herbal medicines, then add carrier zeolite powder 250 grams (fineness is 100 orders), total amount reaches 1000 grams, again mixes, and namely obtains this feed addictive.
The experiment that the formula of Application Example 1 is carried out
Test site: Jiaxing joyful cultivation Co., Ltd.
Time: 2011.3.7-2011.4.19,42 days by a definite date.
Experimental animal: test selects 1 age in days love to pull out young young 320 (male and female half and half) of commercial generation meat increasingly, original body mass difference remarkable (P>0.05) between group in group.Be divided into 4 processed group at random, often group establishes 4 repetitions, each repetition 20 chickens.
Test daily ration: adopt corn-soybean meal basal diet, with reference to U.S. NRC(1998) Broiler chicks nutritional need is formulated, and the trophic level for each processed group of examination animal is identical.Basal diet formula is in table 1.Control group Broiler chicks is fed basal diet, test I group adds 400mg/kg armillaria mellea accreting with Rhizoma Gastrodiae powder on basal diet basis, test II group adds 800mg/kg sub-micron Chinese herbal medicine on basal diet basis, and test III group adds the stone flour that this product 0.2%(substitutes in basal diet 0.2% on basal diet basis).This product is the feed addictive that embodiment 1 prepares.
Table 1
Note: rope premix of 1. supporting one's family (every kilogram of feed provides): support one's family rope A12500IU; Calciferol 500IU; Be below milligram: vitamin e1 8.75, vitamin K
32.65, Cobastab
12, Cobastab
26, Cobastab
120.025, biotin 0.0325, folic acid 1.25, pantothenic acid 12, nicotinic acid 50;
2. microelement pre-mix material (per kilogram feed provides a milligram number): Cu8, Zn75, Fe80, Mn100, Se0.15, I0.35;
3., except metabolizable energy, result is calculated value; Later stage feed does not add any antibiotic, or with armillaria mellea accreting with Rhizoma Gastrodiae powder or astragalus polyose or zeolite powder.
Feeding and management and carry out immunity routinely.
Index determining: weigh and calculate daily ingestion amount, daily gain and feedstuff-meat ratio; Statistics survival rate; Butcher rear separating immune organ and Computation immunity shoot formation; Antibody titer of ND, PBLC conversion ratio, NKT (NK) cellular immune function and interleukin (IL) is detected active after blood sampling.
Data processing method: utilize SPSS(16.0) statistics software carries out variance analysis, adopts the least significant difference (LSD) to carry out Multiple range test.Data represent with average ± standard deviation (X ± SD).
Test result is as following table 2 ~ table 7:
Table 2
Note: the female different person's significant difference of same column shoulder marking-up.
As shown in Table 2, from whole feeding period, compared with control group, the daily ingestion amount of test I group improves 3.86%(p<0.05), daily gain improves 5.99%(p<0.01), feedstuff-meat ratio reduces 2.12%(p<0.05), Broiler chicks survival rate improves 5%; The daily ingestion amount of test II group improves 2.17%(p<0.05), daily gain improves 3.94%(p<0.05), feedstuff-meat ratio reduces 1.59%(p<0.05), Broiler chicks survival rate improves 4%; The daily ingestion amount of test III group improves 5.13%(p<0.01), daily gain improves 8.48%(p<0.01), feedstuff-meat ratio reduces 3.17%(p<0.01), Broiler chicks survival rate improves 6%.That is:, after adding feed addictive of the present invention in daily ration of broiler, broiler chicken daily ingestion amount, daily gain and Broiler chicks survival rate are significantly increased, and broiler chicken feedstuff-meat ratio significantly reduces.
Table 3
Note: the female different person's significant difference of colleague's shoulder marking-up.
As shown in Table 3,21d(21 days, lower same) time, compared with control group, the thymus index of test I group improves 13.16%(p<0.01), index and spleen index improves 20.41%(p<0.01), bursal index improves 13.23%(p<0.01); The thymus index of test II group improves 10.53%(p<0.01), index and spleen index improves 18.37%(p<0.01), bursal index improves 12.06%(p<0.01); The thymus index of test III group improves 20.47%(p<0.01), index and spleen index improves 28.57%(p<0.01), bursal index improves 22.57%(p<0.01).
During 42d, compared with control group, the thymus index of test I group improves 18.69%(p<0.01), index and spleen index improves 25%(p<0.01), bursal index improves 18.87%(p<0.01); The thymus index of test II group improves 16.26%(p<0.01), index and spleen index improves 21.05%(p<0.01), bursal index improves 17.61%(p<0.01); The thymus index of test III group improves 27.68%(p<0.01), index and spleen index improves 36.84%(p<0.01), bursal index improves 30.19%(p<0.01).
That is: in daily ration of broiler, add feed addictive of the present invention, after eaten by broilers 21d, 42d, thymus index, the Immune Organs Index such as index and spleen index and bursal index of broiler chicken all significantly strengthen.
Table 4
Note: the female different person's significant difference of colleague's shoulder marking-up.
As shown in Table 4, during 21d, compared with control group, the HI antibody titer of test I group improves 26.49%(p<0.01), the HI antibody titer of test II group improves 24.59%(p<0.01), the HI antibody titer of test III group improves 37.03%(p<0.01).
During 42d, compared with control group, the HI antibody titer of test I group improves 26.09%(p<0.01), the HI antibody titer of test II group improves 25.06%(p<0.01), the HI antibody titer of test III group improves 37.60%(p<0.01).
That is: in daily ration of broiler, add feed addictive of the present invention, after eaten by broilers 21d, 42d, the HI antibody titer of broiler chicken significantly increases.
Table 5
Note: the female different person's significant difference of colleague's shoulder marking-up.
As shown in Table 5, during 21d, compared with control group, the T lymphocyte transformation rate of test I group improves 24.59%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 34.69%(p<0.01); The T lymphocyte transformation rate of test II group improves 19.67%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 28.57%(p<0.01); The T lymphocyte transformation rate of test III group improves 37.70%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 53.06%(p<0.01).
During 42d, compared with control group, the T lymphocyte transformation rate of test I group improves 20.99%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 23.61%(p<0.01); The T lymphocyte transformation rate of test II group improves 16.05%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 18.06%(p<0.01); The T lymphocyte transformation rate of test III group improves 34.57%(p<0.01), bone-marrow-derived lymphocyte conversion ratio improves 38.89%(p<0.01).
That is: in daily ration of broiler, add feed addictive of the present invention, after eaten by broilers 21d, 42d, T lymphocyte transformation rate and the bone-marrow-derived lymphocyte conversion ratio of broiler chicken all significantly increase.
Table 6
Note: the female different person's significant difference of colleague's shoulder marking-up.
As shown in Table 6, during 21d, compared with control group, the NK cytoactive of test I group improves 32.89%(p<0.01), the NK cytoactive of test II group improves 29.62%(p<0.01), the NK cytoactive of test III group improves 51.25%(p<0.01).
During 42d, compared with control group, the NK cytoactive of test I group improves 35.95%(p<0.05), the NK cytoactive of test II group improves 27.90%(p<0.01), the NK cytoactive of test III group improves 44.96%(p<0.01).
That is: in daily ration of broiler, add feed addictive of the present invention, after eaten by broilers 21d, 42d, the NK cytoactive of broiler chicken all significantly increases.
Table 7
Note: the female different person's significant difference of colleague's shoulder marking-up.
As shown in Table 7, during 21d, compared with control group, the IL-2 activity of test I group improves 52.63%(p<0.01), IL-3 activity improves 75%(p<0.01); The IL-2 activity of test II group improves 42.11%(p<0.01), IL-3 activity improves 56.25%(p<0.01); The IL-2 activity of test III group improves 84.21%(p<0.01), IL-3 activity improves 112.5%(p<0.01).
During 42d, compared with control group, the IL-2 activity of test I group improves 66.67%(p<0.01), IL-3 activity improves 92.86%(p<0.01); The IL-2 activity of test II group improves 55.56%(p<0.01), IL-3 activity improves 78.57%(p<0.01); The IL-2 activity of test III group improves 100%(p<0.01), IL-3 activity improves 128.6%(p<0.01).
That is: in daily ration of broiler, add feed addictive of the present invention, after eaten by broilers 21d, 42d, the IL-2 activity of broiler chicken and IL-3 activity all significantly increase.
From above-mentioned test result, add feed addictive of the present invention in daily ration of broiler after, compared with control group, broiler chicken daily ingestion amount, daily gain significantly improve, and the death rate and feedstuff-meat ratio significantly decline; Immunity of meat chickens (comprising Immune Organs Index, HI antibody titer, periphery lymphocyte conversion ratio, NK cytoactive, IL activity index) significantly strengthens.
Claims (5)
1. improve a feed addictive for growth of meat chicken immune performance, it is characterized in that, calculate according to percentage by weight, comprising:
Radix Astragali 8-12%
Folium isatidis 8-12%
Motherwort 4-6 %
Hawthorn 2-3%
Fructus Hordei Germinatus 2-3%
Divine Comedy 2-3 %
Pine needle meal 6-9%
Armillaria mellea accreting with Rhizoma Gastrodiae powder 18-32%
All the other are carrier.
2. the feed addictive of raising growth of meat chicken immune performance according to claim 1, is characterized in that, calculates, comprising according to percentage by weight:
The Radix Astragali 10%
Folium isatidis 10%
Motherwort 5 %
Hawthorn 2.5%
Fructus Hordei Germinatus 2.5%
Divine Comedy 2.5%
Pine needle meal 7.5%
Armillaria mellea accreting with Rhizoma Gastrodiae powder 25%
All the other are carrier.
3. the feed addictive of the raising growth of meat chicken immune performance according to the arbitrary claim of claim 1-2, is characterized in that, described carrier is zeolite powder.
4. the feed addictive of raising growth of meat chicken immune performance according to claim 1, is characterized in that, described feed addictive is when reality uses, and addition is the 0.1-0.5% of feed relative.
5. the feed addictive of raising growth of meat chicken immune performance according to claim 1, is characterized in that, described feed addictive is when reality uses, and addition is the 0.1-0.3% of feed relative.
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| CN104138498A (en) * | 2014-06-28 | 2014-11-12 | 四川农业大学 | Traditional Chinese medicine decoction composition for prompting chicken meat productivity and application thereof |
| CN104857376A (en) * | 2015-05-11 | 2015-08-26 | 安阳工学院 | Compound traditional Chinese medicine capable of promoting growing of broilers |
| CN105106315A (en) * | 2015-08-28 | 2015-12-02 | 河南大德广动物药业有限公司 | Traditional Chinese medicine formulation for promoting growth and development of viscera of young poultry and preparation method thereof |
| CN106360040B (en) * | 2016-08-24 | 2019-12-31 | 广东海大集团股份有限公司 | Composite Chinese herbal medicine probiotic feed additive for enhancing growth performance and immune function of broiler chickens |
| CN107183397A (en) * | 2017-04-16 | 2017-09-22 | 苫君强 | Improve the preparation method of the feed addictive of quail immunologic function |
| CN110250357A (en) * | 2019-06-11 | 2019-09-20 | 云南农业大学 | A kind of Chinese herbal feed additive improving meat chicken growth performance |
| CN116870091B (en) * | 2023-07-13 | 2024-04-12 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
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| CN101965915A (en) * | 2010-08-25 | 2011-02-09 | 济南百鸣生物制药有限公司 | Broiler chicken feed additive and preparation method thereof |
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| CN101543261A (en) * | 2009-04-20 | 2009-09-30 | 重庆开洲牧业科技开发有限公司 | Chinese medicinal herb additive for meat chickens and application |
| CN101589769A (en) * | 2009-07-07 | 2009-12-02 | 金陵科技学院 | Compound Chinese herbal feed additive of a kind of fryer and its production and application |
| CN101965915A (en) * | 2010-08-25 | 2011-02-09 | 济南百鸣生物制药有限公司 | Broiler chicken feed additive and preparation method thereof |
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