CN103892048B - Piglet is calmed the nerves to increase and exempts from growth-promoting feedstuff additive, preparation method and application thereof - Google Patents
Piglet is calmed the nerves to increase and exempts from growth-promoting feedstuff additive, preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a kind of piglet calm the nerves increase exempt from growth-promoting feedstuff additive, comprising: the red sage root, polygala root, grass-leaved sweetflag, L-thiamine and nano level modified montmorillonite. The present invention also provides preparation method and application's method of above-mentioned feed addictive. It is that primary raw material prepares feed addictive by multiple Chinese herbal medicine and L-thiamine that the present invention adopts, and realizes the coordination linkage of multiple Chinese herbal medicine and L-thiamine, can make piglet daily ingestion amount, daily gain significantly improve, and material anharmonic ratio and Scours index significantly decline; Immunologic function (comprising Immune Organs Index, periphery blood T lymphocyte conversion ratio, immunoglobulin content, IL activity index) significantly strengthens; Anti-oxidation function (comprising serum glutathione peroxidase, superoxide dismutase and catalase activity) significantly strengthens, and also has obvious anti-stress effect.
Description
Technical field
The invention belongs to field of feed additive technology, specifically relate to a kind of piglet growth that improvesFeed addictive, the preparation side of can, improve immunity, improve oxidation resistance and strengthen antistress functionMethod and application thereof.
Background technology
Along with developing rapidly and the continuous expansion of the scale of raising pigs of aquaculture, in modernized pig raising is producedProgressively popularize the early weaned technology of piglet. Early-weaned piglets is due to growth, physiology spyPoint and environment, nutrition, stress wait the impact of factor, there will be a series of stress reaction, mainly tableNow growth retardation, premunition weak, be afraid of cold and suffer from diarrhoea, finally cause piglet survival ratio low, give cultivationVery large economic loss has been brought in field (family), therefore, needs suitable product to solve this in productionA large difficult problem.
Undeniable, in the past few decades, antibiotic is being prevented and treated animal disease as feed addictiveDisease, improves breeding performonce fo animals aspect and has played huge effect. But, antibiotics additiveLong-term use, causes many adverse consequences, makes germ produce drug resistance, and then in livestock productsThe residual health that has influence on people. For this reason, developed country is used and has carried out strict restriction antibiotic,Within 2006, European Union forbids fodder antibiotics comprehensively. The new feed addictive management rules of China are also to antibiosisStrict regulations have been made in the use of element additive.
Therefore, the growth promotion of the safety of development of new, increase immunity, anti-stress with oxidation resistant feedAdditive is to overcome in animal production process, to occur hypoimmunity, improve animal product quality safetyAnd overcome the optimal path that stress wait problem. For example publication number is that 103504138A discloses oneAdditive for feed for piglets, is made up of the material combination of following weight proportioning: every kilogram of pig starter feed addsAgent is containing amino acid chelate iron 50-200g, zinc-amino acid chelate 50-100g, quinocetone 50-100g, dysenteryThe clean 50-100g of bacterium, all the other are carrier. This feed addictive has prevention dysentery, promotes the merit of growthEnergy. But above-mentioned feed addictive mainly adopts western medicine composition, easily cause medicament residue. Moving at presentThing nutritionist carrys out substitute antibiotics seeking natural active matter. Mainly research and develop prebiotic both at home and abroadThe multiple additives such as element, oligosaccharides, plant extracts, Chinese herbal medicine, to growth promotion, improve immunity,Anti-stress having certain effect, but effect does not have breakthrough progress.
We,, in having accepted multinomial provinces and cities scientific research project, are devoted to the research of theanine always,It can be produced by extraction in tealeaves, microorganism fermentation and chemical synthesis, and cost is controlled, ringPacking pressure is little, does not have the problem of resource shortage. The theanine aqueous solution is subacidity, have sweet taste andFresh refreshing taste. Except being proportionate with tea flavour, also have promote cerebral neural growth, antitumor,Hypertensive tranquilizing, the gentle solution of antianxiety tired, anti-ly stress, be helped smoking cessation, promotes growth, raising machineThe effects such as body immunity, can be used as novel antidepressant and green hypnotic etc. (U.S. of a lot of developed countryState, Japan, European Union etc.) it is listed in to medicine, food additives. And China only using its asNew medicine product are used, and not yet list in food additives and food enrichment. We pass throughThe discovery of animal experiment Primary Study, theanine can effectively improve animal immune ability and resist stress energyPower, and promote growth of animal is that a kind of immunity of novel green safety and environmental protection is anti-stress additive. KnotClose our research as feed addictive at Chinese herbal medicine in early days, comprise that improving the calm Chinese medicine of immunity joinsSide and process technology (cellular level pulverizing technology), can be used as supporting technology and further investigate,Form brand-new growth promotion, increase immunity, anti-stress and antioxidant, be expected to solve upper in producingState a difficult problem.
Summary of the invention
The invention provides a kind of piglet and calm the nerves to increase and exempt from growth-promoting feedstuff additive, this additive adopts multipleChinese herbal medicine and theanine are that primary raw material prepares, can significantly improve piglet growth performance, immunity,Anti-oxidant and antistress function.
The present invention also provides a kind of above-mentioned piglet to calm the nerves to increase and has exempted from the preparation method of growth-promoting feedstuff additive,This preparation method's technique is simple, can be suitable for suitability for industrialized production.
The present invention also provides a kind of above-mentioned piglet to calm the nerves to increase and has exempted from the application process of growth-promoting feedstuff additive,In application process, can make piglet daily ingestion amount, daily gain significantly improve, Scours index and material anharmonic ratio are aobviousWork declines; Piglet immunological, anti-oxidant and anti-stress ability significantly strengthen.
A kind of piglet is calmed the nerves to increase and exempts from growth-promoting feedstuff additive, comprising: the red sage root, polygala root, grass-leaved sweetflag, L-Theanine and auxiliary material; Described auxiliary material can adopt nano level modified montmorillonite.
As preferably, to calculate according to percentage by weight, described piglet is calmed the nerves to increase and exempts from growth-promoting feedstuff interpolationAgent comprises:
As further preferably, to calculate according to percentage by weight, described piglet is calmed the nerves to increase and exempts from short long raisingFeed additives comprises:
In above-mentioned each traditional Chinese medicinal components:
The red sage root: cold nature, bitter, the thoughts of returning home, the spleen channel, have activating blood to promote menstruation, apocenosis myogenic, menstruation regulatingArteries and veins, effect that reason iliacus is ached, is used for the treatment of angiocardiopathy, to coronary heart disease, hypertension, high bloodFat has extraordinary curative effect.
Polygala root: slightly warm in nature, bitter, pungent, the thoughts of returning home, kidney, lung channel, have the intelligence development of calming the nerves, eliminate the phlegm,Separate strongly fragrant effect, be used for the treatment of palpitation with fear, forgetful, nocturnal emission, insomnia, cough ant phlegm, ulcer sore is swollen.
Grass-leaved sweetflag: warm in nature, taste is pungent, bitter, the thoughts of returning home, stomach warp, have anticonvulsion, to calm the nerves calmness meritEffect, is used for the treatment of that phlegm is turbid closes the disease such as key and damp retention in middle-jiao.
Above-mentioned Chinese medicine all can be selected from commercially available prod.
The present invention also provides and has prepared above-mentioned piglet and calm the nerves and increase the method for growth-promoting feedstuff additive exempted from, bagDraw together:
(1) get required Chinese medicine, section, mixes, and mixed mixture is carried out to coarse crushing,Then carry out cellular level pulverizing, mixture be crushed to average grain diameter be 25～40 microns (approximatelyFineness is 350～500 orders), mix, obtain sub-micron Chinese herbal medicine;
(2) the sub-micron Chinese herbal medicine obtaining and L-thiamine are mixed, then add nano level modified illiteracyDe-stone, mixes and obtains feed addictive.
In step (1), coarse crushing can adopt existing equipment, and general corase grind is to 60 order left and right. EnterRow cellular level pulverizing generally adopts QYF type fluidized bed air flow crusher.
L-thiamine derives from the chemical synthesis of forage science research institute of Zhejiang University, and purity reaches 99%.
The invention provides a kind of above-mentioned piglet and calm the nerves to increase and exempt from the application process of growth-promoting feedstuff additive, shouldFeed addictive is in the time that reality is used, and addition is 0.05～0.20% of feed basal diet gross weight.Further preferred addition is 0.05～0.15% of feed basal diet weight.
Compared with prior art, beneficial effect of the present invention is embodied in:
It is that primary raw material prepares feed interpolation that the present invention adopts multiple Chinese herbal medicine and L-thiamineAgent, realizes the coordination linkage of Chinese herbal medicine and L-thiamine, can significantly promote piglet growth, improve feedUtilization rate; Can prevent and treat Diarrhea after Piglets " Weaning, improve immunity; Can improve piglet anti-stress and antioxygenChange ability, and green safety is without any harmful effect.
Detailed description of the invention
Embodiment 1
Respectively the red sage root, polygala root, grass-leaved sweetflag are dried, then weigh respectively 200 grams of the reds sage root, polygala root 400Gram, 400 grams of grass-leaved sweetflags, then section arranges, and mixes, and first mixed mixture is carried out to 60Order coarse crushing, then adopts QYF type fluidized bed air flow crusher to carry out cellular level pulverizing, mixesIt is 25～40 microns (approximately fineness is 350～500 orders) that thing is crushed to average grain diameter, and total amount reachesTo 1000 grams, obtain this sub-micron Chinese herbal medicine.
Above-mentioned 500 grams of sub-micron Chinese herbal medicines are mixed with 200 grams of L-thiamines, then add nanoscale to changeProperty 300 grams of montmorillonites, total amount reaches 1000 grams, again mixes, and obtains this feed and addsAgent.
The experiment that the formula of Application Example 1 is carried out
Test site: Jiaxing Dun Hao Farming Ltd..
Time: on August 29,20 to 2013 years July in 2013,40 days by a definite date.
Experimental animal: test select the wean three way cross piglet that 320 body weight are close (Du Luoke ×In vain long × Yorkshire), be divided at random four processed group, each processed group male and female half and half, each processing 4Individual repetition, 20 pigs of each repetition. The control group piglet basal diet of feeding, test I group is on basisOn daily ration basis, add this product 0.05% (0.05% zeolite powder in alternative basal diet), test IIGroup is added this product 0.10% (0.10% zeolite powder in alternative basal diet) on basal diet basis,Test III group is added this product 0.15% and (is substituted in basal diet 0.15% boil on basal diet basisStone flour). This product is the feed addictive that embodiment 1 prepares.
Test daily ration: adopt corn-soybean meal basal diet, with reference to U.S. NRC (1998) pork pigNutritional need is formulated, identical for the trophic level of the each processed group of examination animal. Basal diet is joinedFang Jianbiao 1.
Table 1
Note: 1. microelement pre-mix material is provided by forage science research institute of Zhejiang University; 2. in diet, containAntibiotic, is aureomycin 300ppm, salinomycin 60ppm, olaquindox 80ppm; 3. except digestionCan, result is calculated value.
Feeding and management and carry out immunity routinely.
Index determining: weigh and calculate daily ingestion amount, daily gain and material anharmonic ratio; Calculate Scours index;Butcher rear separating immune organ and calculate Immune Organs Index; After blood sampling, detect periphery blood T lymphocyteConversion ratio, immunoglobulin content and cytokine levels; Detection serum glutathione peroxidase,Superoxide dismutase and catalase activity.
Data processing method: utilize SPSS (16.0) statistics software to carry out variance analysis, adoptLittle remarkable subtracting method (LSD) carries out multiple ratio. Data are with average ± standard deviation (X ± SD)Represent.
Test result is as following table 2～table 8:
Table 2
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 2, compared with control group, the body weight of test II group has improved 4.55% (p < 0.01),Daily ingestion amount has improved 4.85% (p < 0.01), and daily gain has improved 9.03% (p < 0.01), and material is heavyThan having reduced by 3.85% (p < 0.01); The body weight of test III group has improved 6.30% (p < 0.01), dayFeed intake has improved 5.68% (p < 0.01), and daily gain has improved 11.57% (p < 0.01), material anharmonic ratioReduce by 5.13% (p < 0.01).
Table 3
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 3, the thymus index of test II group has improved 34.81% compared with control group(p < 0.01), index and spleen index has improved 8.67% (p < 0.01); The thymus index of test III group improves53.33% (p < 0.01), index and spleen index has improved 12.76% (p < 0.01).
Table 4
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 4, compared with control group, the T lymphocyte transformation rate of test II group has improved10.91% (p < 0.05), the T lymphocyte transformation rate of test III group has improved 19.09% (p < 0.01).
Table 5
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 5, compared with control group, the IgA of test II group has improved 30.43% (p < 0.01),IgG has improved 23.28% (p < 0.01), and IgM has improved 47.25% (p < 0.01); Test III groupIgA improved 47.83% (p < 0.01), IgG has improved 26.72% (p < 0.01), IgM improve57.14% (p < 0.01).
Table 6
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 6, compared with control group, the C3 of test III group has improved 37.50% (p < 0.01),Not significantly (p > 0.05) of the C4 difference of each test group.
Table 7
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 7, compared with control group, the Scours index of the test group 15.01-24.04% that declined(p<0.01)。
Table 8
Note: the female different person's significant differences of colleague's shoulder marking-up.
As shown in Table 8, compared with control group, the activity of glutathione peroxidase of test II group is carriedHigh 11.58% (p < 0.01), superoxide dismutase activity has improved 6.82% (p < 0.05), mistakeHydrogen oxide enzymatic activity has improved 5.84% (p < 0.05); The glutathione peroxidase of test III groupActivity has improved 16.92% (p < 0.01), and superoxide dismutase activity has improved 9.79% (p < 0.01),Catalase activity has improved 8.24% (p < 0.01).
From above-mentioned test result, in piglet diet, add after feed addictive of the present invention, with rightCompare according to group, piglet daily ingestion amount, daily gain significantly improve, and material anharmonic ratio and Scours index significantly decline;Immunologic function (comprises that Immune Organs Index, periphery blood T lymphocyte conversion ratio, immunoglobulin (Ig) containAmount, IL activity index) significantly strengthen; Anti-oxidation function (comprise serum glutathione peroxidase,Superoxide dismutase and catalase activity) significantly strengthen.
Claims (4)
- Piglet calm the nerves increase exempt from a growth-promoting feedstuff additive, it is characterized in that,Calculate according to percentage by weight, comprising:The red sage root 8～12%Polygala root 16～24%Grass-leaved sweetflag 16～24%L-thiamine 16～24%Nano level modified montmorillonite 2 4～36%.
- 2. described in claim 1, piglet is calmed the nerves and increases a preparation method who exempts from growth-promoting feedstuff additive, it is characterized in that, comprising:(1) get required Chinese medicine, section, mixes, and mixed mixture is carried out to coarse crushing, then carries out cellular level pulverizing, and it is 25～40 microns that mixture is crushed to average grain diameter, mixes, and obtains sub-micron Chinese herbal medicine;(2) the sub-micron Chinese herbal medicine obtaining and L-thiamine are mixed, then add nano level modified montmorillonite, mix and obtain feed addictive.
- 3. a piglet is calmed the nerves to increase and exempts from growth-promoting feedstuff additive in the application of preparing in feed, it is characterized in that, described feed addictive is that piglet claimed in claim 1 is calmed the nerves to increase and exempts from growth-promoting feedstuff additive, described feed addictive is in the time that reality is used, and addition is 0.05 ~ 0.20% of feed basal diet weight.
- Piglet according to claim 3 calm the nerves increase exempt from growth-promoting feedstuff additive in the application of preparing in feed, it is characterized in that, described feed addictive is in the time that reality is used, addition is the 0.05-0.15% of feed basal diet weight.
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| CN101554205A (en) * | 2009-05-18 | 2009-10-14 | 肖文军 | Application of L-theanine as feed additive and corresponding feed |
| CN103250872A (en) * | 2013-04-22 | 2013-08-21 | 安徽圣芝堂生物科技有限公司 | Chinese medicine mixed pig feed and preparation method thereof |
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| CN1104039A (en) * | 1993-12-22 | 1995-06-28 | 黄明和 | Chengji additive for fodder |
| CN101554205A (en) * | 2009-05-18 | 2009-10-14 | 肖文军 | Application of L-theanine as feed additive and corresponding feed |
| CN103250872A (en) * | 2013-04-22 | 2013-08-21 | 安徽圣芝堂生物科技有限公司 | Chinese medicine mixed pig feed and preparation method thereof |
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