CN104012807B - A kind of livestock and poultry antiviral B B-complex premixed feed preparation and preparation method and application thereof - Google Patents
A kind of livestock and poultry antiviral B B-complex premixed feed preparation and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses the antiviral B B-complex premixed feed preparation of a kind of livestock and poultry, be made up of the component of following weight portion: vitamin: 25 ~ 28 parts; Amino acid: 10 ~ 14 parts, polysaccharide: 56 ~ 44.5 parts, Chinese medical extract: 8-12 part, anticaking agent: 1 ~ 1.5 part.The present invention aims to provide a kind of by suppressing copying of virus, promote fowl poultry immune allelotaxis, regulate active immune function, participate in the immune response of body, strengthen the immunity of body, induction body produces interferon rapidly, has and improves rapidly livestock and poultry body non-specific immune function, improve livestock and poultry resistances against diseases, the preparation of antiviral B B-complex premixed feed preparation of the livestock and poultry of potent antistress function; And prepare the preparation method and application of these livestock and poultry with antiviral B B-complex premixed feed preparation.
Description
Technical field
The present invention relates to animal feed additive field, particularly the antiviral B B-complex premixed feed preparation of a kind of livestock and poultry, and its preparation method and application.
Background technology
Viral disease is the disease of the most headache of current livestock and poultry breeding industry, although traditional antiviral Western medicine has certain effect, but in order to ensure animal food safety, protect the health of people, China just issued in 2005 " emergency notice about checking the antiviral drugs such as amantadine ", and clear stipulaties forbids sale and the use of the antiviral veterinary drugs such as amantadine, Ribavirin, moroxydine.The current medicines such as Chinese herb on the prevention, interferon, immunoglobulin (Ig), ASON and ribozyme of generally taking are prevented and treated, but generally all there is the drawbacks such as curative effect is indefinite, use cost is high, easy generation drug resistance, the clinical treatment therefore for virosis does not have very good way really.
Chinese Patent Application No. CN201210390810.3 discloses a kind of chick toxic removing soup and manufacture thereof, using method, it mainly adopts Radix Codonopsis, the Radix Astragali, dandelion, honeysuckle, Radix Isatidis, folium isatidis, a kind of toxic removing soup prepared by Radix Glycyrrhizae, toad, for strengthening the immunity of chick, antibiotic pure Chinese medicinal preparation as an alternative.
Chinese Patent Application No. CN201110094957.3 disclose a kind of livestock composite premix compound containing traditional Chinese medicine ingredients and, it mainly adopts multivitamin, amino acid and using the Radix Astragali, hawthorn, Radix Isatidis and Radix Glycyrrhizae as the mix preparation of the Chinese medical extract of primary raw material, for replenishing vitamins, amino acid, there is the features such as stomach invigorating nourishing the stomach, antiviral, develop immunitypty.
But mostly anti-virus ability is poor, take effect slow, the shortcoming such as consumption is large for the feed addictive with antiviral Chinese medicine preparation of the prior art.
Summary of the invention
The object of the present invention is to provide a kind of by suppressing copying of virus, promote fowl poultry immune allelotaxis, improve livestock and poultry resistance against diseases, the antiviral B B-complex premixed feed preparation of livestock and poultry of potent antistress function, the preparation method that another object of the present invention is to provide these livestock and poultry with antiviral B B-complex premixed feed preparation and embody rule.
Main Ingredients and Appearance L-AA of the present invention, can reduce body capillary permeability, can reduce the secretion of glucocorticoid, avoids because its secretion excessive concentration and produce immunosupress, strengthen body to high temperature, cold etc. stress adaptive faculty.Have stronger reproducibility, enzymatic protective system, participate in the synthesis of dopamine norepinephrine, enhancing antibody generates and strengthens leukocytic phagocytic activity, and suppress copying of viral DNA and RNA, induction body produces interferon, thus enhanced machine body immunity function.Another compatibility composition DL-ɑ-tocopherol acetate of the present invention is important antioxidant, and main Cell protection film and Subcellular membrane, from Peroxidative damage, can not only strengthen humoral immune reaction, and can improve the function of cellular immune function and neutrophil.L-AA itself does not possess lipid peroxidation inhibition effect, but under DL-ɑ-tocopherol acetate existent condition, higher lipid peroxidation inhibition effect can be had, and L-AA can reduce DL-ɑ-tocopherol acetate free radical, recover the antioxidation of DL-ɑ-tocopherol acetate.Another composition taurine is a kind of amino acid with extensive physiologically active; there is protection lymphocyte and can promote that it is bred; produce the effect of antibody; also can promote that macrophage produces interleukins, suppress the generation of free radical, the activity of protection antioxidase (SOD); reduce peroxidatic reaction of lipid; the integrality of Cell protection film, increases the secretory volume of trilute (T3), increases the resisting stress level of body.Therefore DL-ɑ-tocopherol acetate, L-AA and taurine compatibility can be worked in coordination with and be improved antioxidation; prevent or reduce protein oxidation, lipid peroxidation and various stress reaction; eliminate the free radical that the effect of body endoperoxides produces, there is very strong resisting stress, improve immunization.
Polysaccharide composition FOS in the present invention participates in Cellular Immunity directly as immunologic adjuvant and antigen and humoral immunity regulates, promote hepatic secretion glycoprotein, immune response is caused in conjunction with bacterium, with the PHA specific binding on pathogen surface, slow down antigen to absorb, stimulate body immune system, improve the immune response ability of animal.Saccharicter-penin has Promote immunity allelotaxis, improve Immune Organs Index and Amount of Mast Cells, increase the activity of macrophage, lymphocyte, interleukins, Promote immunity transformation, maturation, improve antibody horizontal, regulate the content of CAMP/CGMP and the generation of complement, increase the effects such as the secretory volume of trilute (T3), there is the effect of calmness, pain relieving, antipyretic, antibechic and anti-inflammatory; Papillary energy conditioner vivo environment balances, reduce body to stress sensitiveness, coordinate immunoregulation effect, can trivial solution except the immunosupress that stress produce, improve the anti-stress ability of animal.
Chinese medicinal ingredients Radix Codonopsis in the present invention, Radix Astragali invigorating qi for consolidating superficies, air making-up and spleen enlivening is monarch drug in a prescription altogether, and honeysuckle, clearing heat and detoxicating, the cool blood relieve sore throat of Radix Isatidis, the loose heresy of thin heat are ministerial drug altogether, barrenwort kidney-replenishing, strengthening the bones and muscles, wines used as antirheumatic is adjutant, Radix Glycyrrhizae benefit gas and in, coordinate all medicines, for making medicine, all medicines share, and play altogether to mend and loose doublely to execute, clearing heat and detoxicating, the beneficial gas of righting, consolidate a liter positive effect, there is the excitatory state of adjustment livestock and poultry nervous centralis, reduce sympathoadrenal nervous excitation, promote central immune organ (thymus gland, bursa of Fabricius etc.) and peripheral immune organ (spleen, lymph node etc.) growth, increase total white blood cells and phagocytic function, strengthen the activate the phagocytic capacity of macrophage, promote T cell propagation, inducement interferon IFN-γ, improve T lymphocyte quantity, promote lymphocytic conversion, strengthen cytophagous function, improve local blood circulation, and there is Promote immunity underactivity, amphicheirality's regulating action that Immunosuppression function is too high.There is very strong resisting stress, improve immunologic function.
The present invention is not the simple drug effect superposition of vitamin, polysaccharide, amino acid, Chinese medicinal ingredients, but the cooperative compensating that the interaction of these compositions produces afterwards, bidirectional modulation, Yin Yang balancing, multipath, multi-faceted synergy.Can play obvious Promote immunity allelotaxis, induction body produces interferon rapidly, rapidly improves livestock and poultry body non-specific immune function and reaches antivirus action, has the multiple actions such as antipyretic, analgesia, anti-inflammatory, resisting stress, growth promotion simultaneously.
Concrete technical scheme of the present invention is: the antiviral B B-complex premixed feed preparation of a kind of livestock and poultry, is made up of the component of following weight portion: vitamin: 25 ~ 28 parts; Amino acid: 10 ~ 14 parts, polysaccharide: 56 ~ 44.5 parts, Chinese medical extract: 8-12 part, anticaking agent: 1-1.5 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece is: 9 ~ 11:16 ~ 14:28 ~ 32:, 32 ~ 28:9 ~ 11:6 ~ 4.
Preferably, the antiviral B B-complex premixed feed preparation of above-mentioned livestock and poultry is made up of the component of following weight portion: vitamin: 27 ~ 28 parts; Amino acid: 13 ~ 14 parts, polysaccharide: 48 ~ 44.8 parts, Chinese medical extract: 11 ~ 12 parts, anticaking agent: 1 ~ 1.2 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, and the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae is: 9.5 ~ 10.5:14.5 ~ 15.5:29 ~ 31:29 ~ 31:9.5 ~ 10.5:4.8 ~ 5.2.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, described Chinese medical extract is obtained by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by above-mentioned weight ratio;
Step 2: the honeysuckle taken in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, carry out diacolation by percolation 70% ethanol as solvent with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taken in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece cleaning are placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water added in step 3 is 3 ~ 5 times of each Chinese medicine gross weight that take in step 1, boils; 80 ~ 85 DEG C of constant temperature decoct 1 ~ 1.5 hour, then heating is boiled the 30 minutes weight to liquid and become 1/8 ~ 1/12 of former amount of water, is separated upper liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again the water being equivalent to 2 ~ 3 times of solid medicine slag blanket weight, boil; 80 ~ 85 DEG C of constant temperature decoct 1 hour, then heating to boil 30 minutes be 1/8 ~ 1/12 of institute's amount of water in step 4 to liquid, leach upper liquid;
Step 5: by step 2 obtain honeysuckle concentrate, upper liquid that step 3 obtains and the upper liquid that step 4 obtains mix, put into concentration pan and concentrate, being concentrated into density is 1.38 ~ 1.40g/cm
3time (70 DEG C), carry out spraying dry, obtain the Chinese medical extract of solvable chocolate brown powder shape.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10 ~ 1/15.
Preferably, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/12 ~ 1/13.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, described vitamin comprises L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 8 ~ 12 parts, 0.8 ~ 1.2 part, 12 ~ 8 parts, 4.2 ~ 6.8 parts.
Preferably, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 9 ~ 11 parts, 1.0 ~ 1.1 parts, 11 ~ 9 parts, 5 ~ 6 parts.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, described amino acid comprises taurine and silkworm compound amino acid, and the weight portion of described taurine and silkworm compound amino acid is respectively: 9 ~ 11 parts: 1 ~ 3 part.
Preferably, the weight portion of described taurine and silkworm compound amino acid is respectively: 9.5 ~ 10.5 parts: 1.5 ~ 2 parts.
Above-mentioned livestock and poultry with in antiviral B B-complex premixed feed preparation, described polysaccharide comprises FOS and saccharicter-penin, and described FOS and the weight portion of saccharicter-penin are respectively: 52 ~ 36.5 parts, 4 ~ 8 parts.
Preferably, described FOS and the weight portion of saccharicter-penin are respectively: 50 ~ 38 parts, 5 ~ 7 parts.
The present invention also provides the preparation method of the above-mentioned antiviral B B-complex premixed feed preparation of livestock and poultry, and it specifically comprises the steps:
Step 1: take concentration by above-mentioned weight portion and be not less than 50%DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT; And take the FOS equal with the gross weight of DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT, and cross 40 order stainless steel sifts after premixed, for subsequent use;
Step 2: the FOS taking L-AA, niacinamide, taurine, Chinese medical extract, anticaking agent and remaining weight portion by above-mentioned weight portion, mixture after the premixed obtained with step 1 puts into three-dimensional mixer, mixing 15-20 minute, obtain taupe, color uniformity, without conglomeration, without the even soluble powder of color spot;
Step 3: step 2 gained mixture is carried out the detections such as moisture content, granularity, discriminating, content on request, carries out packing after qualified on request, sealing, vanning, warehouse entry.
Examination criteria:
1. sanitary index: GB13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: (1) gets this product 0.2g, after the 10ml that adds water dissolves, the infrared Absorption collection of illustrative plates of this product should be consistent with the collection of illustrative plates that L-AA contrasts (spectra collection 450 figure);
(2) in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should with the retention time consistent (GB/T17812) at DL-ɑ-tocopherol acetate reference substance peak.
5. assay: L-AA >=80g/kg (GB/T17816), DL-ɑ-tocopherol acetate >=4g/kg (GB/T17812).
In the preparation method of above-mentioned livestock and poultry with antiviral B B-complex premixed feed preparation, described Chinese medical extract is obtained by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by above-mentioned weight ratio;
Step 2: the honeysuckle taken in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, carry out diacolation by percolation 70% ethanol as solvent with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taken in step 1, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece cleaning are placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water added in step 3 is 3 ~ 5 times of each Chinese medicine gross weight that take in step 1, boils; 80 ~ 85 DEG C of constant temperature decoct 1 ~ 1.5 hour, then heating is boiled the 30 minutes weight to liquid and become 1/8 ~ 1/12 of former amount of water, is separated upper liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again the water being equivalent to 2 ~ 3 times of solid medicine slag blanket weight, boil; 80 ~ 85 DEG C of constant temperature decoct 1 hour, then heating to boil 30 minutes be 1/8 ~ 1/12 of institute's amount of water in step 4 to liquid, leach upper liquid;
Step 5: by step 2 obtain honeysuckle concentrate, upper liquid that step 3 obtains and the upper liquid that step 4 obtains mix, put into concentration pan and concentrate, being concentrated into density is 1.38 ~ 1.40g/cm
3time (70 DEG C), carry out spraying dry, obtain the Chinese medical extract of solvable chocolate brown powder shape.
In the preparation method of above-mentioned livestock and poultry with antiviral B B-complex premixed feed preparation, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10 ~ 1/15.
Preferably, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/12 ~ 1/13.
The present invention also provides the above-mentioned application of the antiviral B B-complex premixed feed preparation of livestock and poultry in livestock and poultry cultivation, the antiviral B B-complex premixed feed preparation of described livestock and poultry is added in the drinking water of livestock and poultry or is added in the daily ration of livestock and poultry, described livestock and poultry with the ratio of the drinking water of antiviral B B-complex premixed feed preparation and livestock and poultry for: the drinking water of the livestock and poultry of 2000L adds the antiviral B B-complex premixed feed preparation of livestock and poultry described in 1kg; Described livestock and poultry with the ratio of the daily ration of antiviral B B-complex premixed feed preparation and livestock and poultry for: add the antiviral B B-complex premixed feed preparation of livestock and poultry described in 1kg in the daily ration of the livestock and poultry of 1000kg.
The present invention is by L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, taurine, compound amino acid, FOS, saccharicter-penin, and by Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, the Chinese herbal medicines such as Radix Glycyrrhizae concentrate the compositions such as active ingredient, by suppressing copying of virus, promote fowl poultry immune allelotaxis, regulate active immune function, participate in the immune response of body, strengthen the immunity of body, induction body produces interferon rapidly, have and improve rapidly livestock and poultry body non-specific immune function, improve livestock and poultry resistance against diseases, potent resisting stress.
The present invention, antiviral while, have the multiple actions such as antipyretic, anti-inflammatory, resisting stress concurrently, has multiple action to the infection that virus causes, and the time that can shorten heating, the diffusion controlled inflammation, promotes the absorption etc. of inflammation, namely multipath, multi-facetedly to work; And can also enhanced machine body immunity function, stop cell entry cell tissue, toxic and side effect is less, and virus is difficult to develop immunity to drugs to it, and make the present invention have obvious advantage in control livestock and poultry virus infectious diseases, Clinical practice has a extensive future.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
1, Chinese medical extract is prepared.
Step 1.1: take Radix Codonopsis 10kg, honeysuckle 15kg, Radix Astragali 30kg, Radix Isatidis 30kg, barrenwort 10kg, Radix Glycyrrhizae 5kg;
Step 1.2: the honeysuckle taken is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, carry out diacolation by percolation 70% ethanol as solvent with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 1.3: the Radix Codonopsis taken, the Radix Astragali, Radix Isatidis, barrenwort, licorice piece cleaning are placed in extractor, add the honeysuckle dregs of a decoction of step 1.2 gained, add water 400kg, boil; 80 ~ 85 DEG C of constant temperature decoct 1.5 hours, then 40 ± 1kg that 30 minutes weight to liquid becomes former amount of water is boiled in heating, is separated upper liquid and solid medicine slag blanket;
Step 1.4: the solid medicine slag blanket in step 1.3 is added again the water being equivalent to 2.5 times of solid medicine slag blanket weight, boil; 80 ~ 85 DEG C of constant temperature decoct 1 hour, then heating to boil 30 minutes be 1/10 of institute's amount of water in step 1.4 to liquid, leach upper liquid;
Step 1.5: by step 1.2 obtain honeysuckle concentrate, upper liquid that step 1.3 obtains and the upper liquid that step 1.4 obtains mix, put into concentration pan and concentrate, thickening temperature is 100 ± 5 DEG C, and being concentrated into density is 1.38 ~ 1.40g/cm
3time (70 DEG C), carry out spraying dry, obtain the Chinese medical extract of solvable chocolate brown powder shape, weight is 8.5 ± 1kg.
2, the antiviral B B-complex premixed feed preparation of livestock and poultry is prepared.
Step 2.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate 1kg, silkworm compound amino acid 2kg, saccharicter-penin 5kg, VBT 5kg and FOS 13kg, crosses 40 order stainless steel sifts after premixed, for subsequent use;
Step 2.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, Chinese medical extract 10kg, anticaking agent 1kg and FOS 33kg, mixture after the premixed obtained with step 2.1 puts into three-dimensional mixer, mix 18 minutes, obtain taupe, color uniformity, without conglomeration, without the even soluble powder 100kg of color spot;
Step 3.3: step 2 gained mixture is carried out the detections such as moisture content, granularity, discriminating, content on request, obtains sample 1 after qualified.
Examination criteria:
1. sanitary index: GB13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. moisture content≤10% (GB/T6435);
3. granularity: all by aperture be 1.19mm analyze sieve, aperture be 0.59mm analyze sieve oversize must not be greater than 10%.(GB/T5917.1)；
4. differentiate: (1) gets this product 0.2g, after the 10ml that adds water dissolves, the infrared Absorption collection of illustrative plates of this product should be consistent with the collection of illustrative plates that L-AA contrasts (spectra collection 450 figure);
(2) in the chromatogram recorded under DL-ɑ-tocopherol acetate assay item, the retention time at test sample peak should with the retention time consistent (GB/T17812) at DL-ɑ-tocopherol acetate reference substance peak.
5. assay: L-AA >=80g/kg (GB/T17816), DL-ɑ-tocopherol acetate >=4g/kg (GB/T17812).
Embodiment 2:
Identical with preparation technology with the formula of embodiment 1, different places is, the weight of each taste Chinese medicine taken is: take Radix Codonopsis 9.5kg, honeysuckle 15.5kg, Radix Astragali 29kg, Radix Isatidis 31kg, barrenwort 10.3kg, Radix Glycyrrhizae 4.7kg.
Embodiment 3:
Identical with preparation technology with the formula of embodiment 1, different places is, the weight of each taste Chinese medicine taken is: take Radix Codonopsis 10.5kg, honeysuckle 14.5kg, Radix Astragali 31kg, Radix Isatidis 29kg, barrenwort 9.7kg, Radix Glycyrrhizae 5.3kg.
Embodiment 4:
Identical with preparation technology with the formula of embodiment 1; different places is; vitamin and amino acid whose content change to some extent; its concrete weight is: concentration is not less than 50%DL-ɑ-tocopherol acetate 1.5kg; silkworm compound amino acid 2.5kg, VBT 5.5kg, L-AA 11kg; niacinamide 11kg, taurine 11kg.
Embodiment 5:
Identical with preparation technology with the formula of embodiment 1, different places is, the content of polysaccharide changes to some extent, and it is specially: the saccharicter-penin in step 2.1 is 4kg, and FOS is 12kg, and the FOS added in step 2.2 is 31.5kg.
Comparative example 1
Preparation contrast sample 1.
Step 3.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate 1kg, silkworm compound amino acid 2kg, saccharicter-penin 5kg, VBT 5kg and FOS 13kg, crosses 40 order stainless steel sifts after premixed, for subsequent use;
Step 3.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, anticaking agent 1kg and FOS 43kg; mixture after the premixed obtained with step 3.1 puts into three-dimensional mixer; mix 18 minutes; obtain 100kg canescence; color uniformity; without conglomeration, the even soluble powder without color spot is contrast sample 1.
Comparative example 2
Preparation contrast sample 2.
Step 4.1: take concentration and be not less than 50%DL-ɑ-tocopherol acetate powder 1kg, silkworm compound amino acid 2kg, VBT 5kg, crosses 40 order stainless steel sifts after premixed, for subsequent use;
Step 4.2: take L-AA 10kg, niacinamide 10kg, taurine 10kg, Chinese medical extract 61kg; anticaking agent 1kg; mixture after the premixed obtained with step 4.1 puts into three-dimensional mixer; mix 18 minutes; obtain 100kg taupe; color uniformity, without conglomeration, the even soluble powder without color spot is contrast sample 2.
Wherein, the preparation technology of Chinese medical extract is identical with embodiment 1 with formula.
Animal feeding embodiment 1
Sample 1, contrast sample 1 and contrast sample 2 are on the impact of meat chicken production performance.
1. materials and methods
1.1 for examination animal and grouping
The fast large yellow-feather broiler of Wen Shi of 1 age in days unified raising after one week, randomly drawed 600, was divided into 4 groups, often organize 3 repetitions, each repetition 50, divide experiment I group, test II group, test III group, blank group, and take original body mass; Test I group by drinking-water interpolation 0.5 ‰ embodiment 1 sample 1, being used in conjunction 3 days is every other week a course for the treatment of; Test II group and contrast sample 1 by drinking-water interpolation 0.5 ‰ comparative example 1, being used in conjunction 3 days is every other week a course for the treatment of; Test III group and contrast sample 2 by drinking-water interpolation 0.5 ‰ comparative example 2, being used in conjunction 3 days is every other week a course for the treatment of; Blank group only adds basal diet pellet and daily drinking water.Experimental group and blank group all adopt raises in cages, and free choice feeding is drunk water, and four groups, basal diet pellet is identical, and concrete formula is corn 55.3%, dregs of beans 36%, calcium monohydrogen phosphate 1.8%, stone flour 1%, fat oil 1.4%, fish meal 2.5%, premix 2%.Adopt conventional feeding and management, record broiler chicken daily feed intake, dead quantity, regularly carry out immunity and cleaning hen house, test breeding cycle is 35 days.
2. growth performance measures
Weigh to after healthy chicken on an empty stomach 3h in units of group respectively at 14,21,28,35,42 ages in days, freely drink water on an empty stomach, precise and record day feed quantity, residue doses, loss doses and dead quantity, calculate each stage average daily gain, average daily ingestion amount, feedstuff-meat ratio and survival rate.
The initial average weight of 7 age in days: only test I group of 101.5g/, only tests II group of 101.2g/, only tests III group of 100.8g/, and blank group 101.4g/ only.
2.1 results and data
Table one:
Result of the test shows:
Feed sample 1, contrast sample 1 and contrast sample 2 all can reduce the feedstuff-meat ratio of each mensuration age in days, and inventive samples 1 group of feeding is minimum at each mensuration age in days feedstuff-meat ratio, and average daily gain, survival rate are also the most obvious.Although effect might not be embodied in average feed intake or average daily gain, it is the highest for necessarily embodying interpolation inventive samples 1 feed conversion rate.Although sample 1 is closest with contrast sample 2 effect, the cost of material of contrast sample 2 is higher than sample 1 by 2/3rds.Therefore can infer, the antiviral B B-complex premixed feed preparation of livestock and poultry of the present invention not only significantly can reduce feedstuff-meat ratio, reduces use cost, can also significantly improve broiler chicken resistance against diseases and survival rate.
3. the mensuration of immunologic function
Main mensuration Immune Organs Index: Immune Organs Index (mg/g)=immune organ weight/live body weight.
From each group of healthy chicken, 5 chickens are randomly drawed respectively at 14 ages in days, 28 ages in days and 42 ages in days, weigh respectively after 12h on an empty stomach, freely drink water on an empty stomach, after correct amount, heart is squeezed into air method and is put to death chicken, dissect, win spleen and the bursa of farbricius, after rejecting fat, claim fresh weight, calculate spleen and bursal index.
3.1 results and data
Table two:
Result of the test shows:
Be not difficult to find out that the index and spleen index of each experimental group and bursal index are all higher than blank group by table two, inventive samples 1 group of wherein feeding is the peak of each mensuration age in days, and also very remarkable with the difference of other test group.Therefore, the antiviral B B-complex premixed feed preparation of livestock and poultry of the present invention has promotion fowl poultry immune allelotaxis clearly, regulates active immune function, strengthens the immunity of body, improve the effect of livestock and poultry resistance against diseases, and use cost is low.
Animal feeding embodiment 2
Sample 1 is with contrast sample 1 and contrast sample 2 to the comparative test of enhancing piglet immunological ability.
1, materials and methods
(1) material
Get the test material of contrast sample 2 as the present embodiment of the sample 1 of above-described embodiment 1 and the contrast sample 1 of comparative example 1 and comparative example 2.
(2) conceptual design
Subjects is that source is consistent, same parity, the farrowing time is close, litter size is identical, and sex ratio is close, the Du great Chang ternary weanling pig that weight of weaning litter, body weight are close, be divided into experiment I group by paired experiment principle, test II group, test III group and blank group totally 4 groups, often organize 3 repetitions, each repetition 20, totally 240.Test I group of initial head counterpoise (10.16 ± 1.15) kg, test II group of initial head counterpoise (10.18 ± 1.21) kg, test III group of initial head counterpoise (10.22 ± 1.18) kg, blank group initial head counterpoise (10.23 ± 1.25) kg, test I group of sample 1 of feeding, feed week about 3 days; Test II group of contrast sample 1 of feeding, feed week about 3 days; Test III group of contrast sample 2 of feeding, feed week about 3 days; Blank group does not additionally add any medicated premix.1kg sample 1 mix fodder 1000kg, 1kg contrast sample 1 mix fodder 1000kg, and 1kg contrasts sample 2 mix fodder 1000kg, allows piglet free choice feeding, feeding cycle be 50 days.Experimental group and blank group all to be thrown something and fed four particulate material every day, and period regularly cleans pig house, and vaccine program vaccinate.The concrete formula of particulate material is corn 54%, fine rice bran 5.94%, high-quality fish meal 5%, dregs of beans 31%, calcium monohydrogen phosphate 1.2%, stone flour 0.7%, salt 0.16%, premix 2.0%.
The diarrhoea frequency of control group and experimental group is recorded in 50 days.
2, result and data
Table three:
| Test I group | Test II group | Test III group | Blank group | |
| Initial average weight kg | 10.16 | 10.18 | 10.22 | 10.23 |
| Average weight kg after 50 days | 43.16 | 40.78 | 42.12 | 37.38 |
| Incidence of Diarrhea | 1.67％ | 8.33％ | 3.33％ | 36.67％ |
| The death rate | 0％ | 1.67％ | 0％ | 11.67％ |
| Daily gain g/ days | 660 | 612 | 638 | 543 |
Result of the test shows:
Find out that the Incidence of Diarrhea of each experimental group and the death rate are all starkly lower than blank group by table three, daily gain is also apparently higher than blank group; Inventive samples 1 group of effect of wherein feeding is the most obvious, and also very remarkable with the difference of other experimental group.At experimental session, the temperature of one week is had to be continued above 36 DEG C, every physical signs such as the experimental group pig state of mind, appetite, sleep all changes not quite, especially with feed inventive samples 1 group the most steadily, normal, and obviously there is the Heat-temperature stress phenomenons such as yellow short red, the argol difficult defecation of agitation, drowsiness, do not feel like eating, urine in blank group pig.Therefore, the antiviral B B-complex premixed feed preparation of livestock and poultry of the present invention has promotion fowl poultry immune allelotaxis clearly, strengthen the immunity of body, not only significantly improve the growth performance of piglet, significantly can also reduce the incidence of intestine of young pigs disease and improve resistance against diseases, potent resisting stress, and use cost is low, and cost performance is the highest.
Above-describedly be only preferred embodiment of the present invention, all do within the scope of the spirit and principles in the present invention any amendment, equivalently to replace and improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. the antiviral B B-complex premixed feed preparation of livestock and poultry, is characterized in that, be made up of: vitamin the component of following weight portion: 25 ~ 28 parts; Amino acid: 10 ~ 14 parts, polysaccharide: 56 ~ 44.5 parts, Chinese medical extract: 8 ~ 12 parts, anticaking agent: 1 ~ 1.5 part; Wherein, described Chinese medical extract is the concentrated extract of Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae, the weight ratio of described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae is: 9 ~ 11:16 ~ 14:28 ~ 32:, 32 ~ 28:9 ~ 11:6 ~ 4;
Described vitamin is made up of L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT, the weight portion of described L-AA, DL-ɑ-tocopherol acetate, niacinamide, VBT is respectively: 8 ~ 12 parts, 0.8 ~ 1.2 part, 12 ~ 8 parts, 4.2 ~ 6.8 parts;
Described amino acid is made up of taurine and silkworm compound amino acid, and the weight portion of described taurine and silkworm compound amino acid is respectively: 9 ~ 11 parts, 1 ~ 3 part;
Described polysaccharide is made up of FOS and saccharicter-penin, and described FOS and the weight portion of saccharicter-penin are respectively: 52 ~ 36.5 parts, 4 ~ 8 parts;
Described Chinese medical extract is obtained by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by described weight ratio;
Step 2: the honeysuckle taken in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, carry out diacolation by percolation 70% ethanol as solvent with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taken in step 1, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae cleaning are placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water added in step 3 is 3 ~ 5 times of each Chinese medicine gross weight that take in step 1, boils; 80 ~ 85 DEG C of constant temperature decoct 1 ~ 1.5 hour, then heating is boiled the 30 minutes weight to liquid and become 1/8 ~ 1/12 of former amount of water, is separated upper liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again the water being equivalent to 2 ~ 3 times of solid medicine slag blanket weight, boil; 80 ~ 85 DEG C of constant temperature decoct 1 hour, then heating to boil 30 minutes be 1/8 ~ 1/12 of institute's amount of water in step 4 to liquid, leach upper liquid;
Step 5: by step 2 obtain honeysuckle concentrate, upper liquid that step 3 obtains and the upper liquid that step 4 obtains mix, put into concentration pan and concentrate, under the condition of 70 DEG C, be concentrated into density is 1.38 ~ 1.40g/cm
3time, carry out spraying dry, obtain the Chinese medical extract of solvable chocolate brown powder shape.
2. the antiviral B B-complex premixed feed preparation of livestock and poultry according to claim 1, it is characterized in that, the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10 ~ 1/15.
3. the antiviral B B-complex premixed feed preparation of livestock and poultry according to claim 2, it is characterized in that, the antiviral B B-complex premixed feed preparation of described livestock and poultry is added in the drinking water of livestock and poultry or is added in the daily ration of livestock and poultry, described livestock and poultry with the ratio of the drinking water of antiviral B B-complex premixed feed preparation and livestock and poultry for: the drinking water of the livestock and poultry of 2000L adds the antiviral B B-complex premixed feed preparation of livestock and poultry described in 1kg; Described livestock and poultry with the ratio of the daily ration of antiviral B B-complex premixed feed preparation and livestock and poultry for: add the antiviral B B-complex premixed feed preparation of livestock and poultry described in 1kg in the daily ration of the livestock and poultry of 1000kg.
4. a livestock and poultry as claimed in claim 1 preparation method for antiviral B B-complex premixed feed preparation, is characterized in that, comprise the following steps:
Step 1: take concentration by described weight portion and be not less than 50%DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT; And take the FOS equal with the gross weight of DL-ɑ-tocopherol acetate, silkworm compound amino acid, saccharicter-penin, VBT, and cross 40 order stainless steel sifts after premixed, for subsequent use;
Step 2: the FOS taking L-AA, niacinamide, taurine, Chinese medical extract, anticaking agent and remaining weight portion by described weight portion, three-dimensional mixer is put into together with the mixture after the premixed that step 1 obtains, mix 15 ~ 20 minutes, obtain taupe, color uniformity, without conglomeration, without the even soluble powder of color spot;
Step 3: step 2 gained mixture is carried out the detections such as moisture, granularity, discriminating, content on request, carries out packing after qualified on request, sealing, vanning, warehouse entry.
5. the livestock and poultry according to claim 4 preparation method of antiviral B B-complex premixed feed preparation, is characterized in that: described Chinese medical extract is obtained by following concentration and extraction process:
Step 1: take Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae by described weight ratio;
Step 2: the honeysuckle taken in step 1 is cleaned, add in percolate pot, adding concentration is that 70% ethanolic solution is to soaking full medicinal material, soak 12 hours, carry out diacolation by percolation 70% ethanol as solvent with the speed of 100ml per minute, diacolation is thin out to liquid color, drains the honeysuckle dregs of a decoction, collect filtrate and reclaim ethanol through decompression distillation, obtain honeysuckle concentrate;
Step 3: the Radix Codonopsis taken in step 1, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae cleaning are placed in extractor, add the honeysuckle dregs of a decoction of step 2 gained, add water, the weight of the water added in step 3 is 3 ~ 5 times of each Chinese medicine gross weight that take in step 1, boils; 80 ~ 85 DEG C of constant temperature decoct 1 ~ 1.5 hour, then heating is boiled the 30 minutes weight to liquid and become 1/8 ~ 1/12 of former amount of water, is separated upper liquid and solid medicine slag blanket;
Step 4: the solid medicine slag blanket in step 3 is added again the water being equivalent to 2 ~ 3 times of solid medicine slag blanket weight, boil; 80 ~ 85 DEG C of constant temperature decoct 1 hour, then heating to boil 30 minutes be 1/8 ~ 1/12 of institute's amount of water in step 4 to liquid, leach upper liquid;
Step 5: by step 2 obtain honeysuckle concentrate, upper liquid that step 3 obtains and the upper liquid that step 4 obtains mix, put into concentration pan and concentrate, being concentrated into 70 DEG C of condition lower densities is 1.38 ~ 1.40g/cm
3time, carry out spraying dry, obtain the Chinese medical extract of solvable chocolate brown powder shape.
6. the livestock and poultry according to claim 4 preparation method of antiviral B B-complex premixed feed preparation, is characterized in that: the weight of described Chinese medical extract be described Radix Codonopsis, honeysuckle, the Radix Astragali, Radix Isatidis, barrenwort, Radix Glycyrrhizae gross weight 1/10 ~ 1/15.
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| CN104664068A (en) * | 2015-03-18 | 2015-06-03 | 广东迈科特生物科技有限公司 | Special multivitamin immunopolysaccharide microemulsion preparation for waterfowl and preparation method and application thereof |
| CN104705528A (en) * | 2015-03-31 | 2015-06-17 | 广州益牲宝动物药业有限公司 | Multivitamin fermented Chinese herbal medicine preparation special for breeding sows as well as preparation method and application thereof |
| CN106578362A (en) * | 2015-10-17 | 2017-04-26 | 饶平东泽生物科技有限公司 | Feed additive formula |
| CN105309825A (en) * | 2015-11-30 | 2016-02-10 | 山东绿都安特动物药业有限公司 | Feed additive capable of resisting heat stress and relieving oxidative stress injuries and used for broiler chickens |
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| CN110506843A (en) * | 2019-08-13 | 2019-11-29 | 安徽快康生物科技有限公司 | It is a kind of for building up health, improving the feed addictive and feed of anti-stress ability |
| CN111789190A (en) * | 2020-07-31 | 2020-10-20 | 李志刚 | Traditional Chinese medicine feed additive for improving animal organism immunity, feed and preparation method |
| CN111972539A (en) * | 2020-08-19 | 2020-11-24 | 中兽医(汤阴)生物科技有限公司 | Additive for improving immunity of livestock and poultry organisms and preparation method thereof |
| CN116268196B (en) * | 2022-12-20 | 2024-04-09 | 山东鑫谷健康产业有限公司 | Plant source composite additive and application thereof |
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| CN102308910A (en) * | 2011-04-15 | 2012-01-11 | 广东养宝生物制药有限公司 | Livestock composite premix compound containing Chinese medicinal ingredients and packaging method thereof |
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| CN103181477A (en) * | 2011-12-27 | 2013-07-03 | 北京资源亚太动物药品有限公司 | Antiviral growth-promoting premix feed for pig and preparation method thereof |
| CN102934744A (en) * | 2012-07-03 | 2013-02-20 | 山东绿都安特动物药业有限公司 | Regulating agent capable of resisting stress, promoting growth and improving metabolism for pigs |
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Denomination of invention: A antiviral compound vitamin premixed feed preparation and preparation method for livestock and poultry, and its application Effective date of registration: 20230911 Granted publication date: 20151230 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGDONG GINPIN ANIMAL NUTRITION CO.,LTD. Registration number: Y2023980056223 |
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