CN111972539A - Additive for improving immunity of livestock and poultry organisms and preparation method thereof - Google Patents

Abstract

The invention provides an additive for improving the immunity of livestock and poultry organisms and a preparation method thereof, wherein the additive is prepared from the following raw materials in parts by weight: 15-20 parts of traditional Chinese medicine composition, 10-15 parts of saccharicterpenin, 5-10 parts of amino acid, 2-8 parts of vitamin and 5-10 parts of probiotics; the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts of honeysuckle, 5-10 parts of liquorice, 10-15 parts of astragalus, 2-5 parts of ash bark, 0.5-2 parts of ginseng, 10-15 parts of eucommia bark, 1-5 parts of medlar, 4-8 parts of fermented soybean, 0.5-1 part of mint, 2-5 parts of burdock, 10-15 parts of epimedium herb, 0.5-2 parts of codonopsis pilosula, 5-15 parts of acanthopanax, 1-5 parts of scutellaria baicalensis, 10-20 parts of dried orange peel and 10-15 parts of schizonepeta. The additive can quickly enhance the immunity of organisms, prevent, control and inhibit various bacteria and viruses and diminish inflammation; improving the immune suppression of the organism, clearing away heat and toxic materials, consolidating the constitution and cultivating vigor; improving the conversion rate of the feed, promoting the nutrient absorption of the organism and quickly recovering the damaged function of the organism.

Description

Additive for improving immunity of livestock and poultry organisms and preparation method thereof

Technical Field

The invention relates to the field of veterinary traditional Chinese medicine additives, in particular to an additive for improving the organism immunity of livestock and poultry and a preparation method thereof.

Background

With the intensification degree of animal husbandry in China and the development of feed industry, antibiotics, chemical synthetic drugs and steroid hormones are commonly used, so that the livestock and poultry generate resistance and drug resistance to the original sensitive drugs, and the livestock and poultry are in a sub-health state for a long time due to immunosuppression caused by feed mildew, malnutrition, severe environment, stress and the like, so that the livestock and poultry grow slowly and the breeding benefit is seriously damaged. The existing traditional Chinese medicine additive mainly aims at certain livestock and poultry diseases, has single effect and poor universality, and can not comprehensively prevent and treat the livestock and poultry diseases. In addition, in the preparation process of the traditional Chinese medicine preparation, the extraction process of the effective components of the traditional Chinese medicine is frequently available, and the problems of low extraction rate, large workload and the like exist in the existing traditional Chinese medicine extraction.

Disclosure of Invention

The invention provides an additive for improving the organism immunity of livestock and poultry and a preparation method thereof, which can quickly enhance the organism immunity, prevent, control and inhibit various bacteria and viruses and diminish inflammation; improving the immune suppression of the organism, clearing away heat and toxic materials, consolidating the constitution and cultivating vigor; improving the conversion rate of the feed, promoting the nutrient absorption of the organism and quickly recovering the damaged function of the organism.

The technical scheme of the invention is realized as follows: an additive for improving the immunity of livestock and poultry organisms is prepared from the following raw materials in parts by weight: 15-20 parts of traditional Chinese medicine composition, 10-15 parts of saccharicterpenin, 5-10 parts of amino acid, 2-8 parts of vitamin and 5-10 parts of probiotics.

Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts of honeysuckle, 5-10 parts of liquorice, 10-15 parts of astragalus, 2-5 parts of ash bark, 0.5-2 parts of ginseng, 10-15 parts of eucommia bark, 1-5 parts of medlar, 4-8 parts of fermented soybean, 0.5-1 part of mint, 2-5 parts of burdock, 10-15 parts of epimedium herb, 0.5-2 parts of codonopsis pilosula, 5-15 parts of acanthopanax, 1-5 parts of scutellaria baicalensis, 10-20 parts of dried orange peel and 10-15 parts of schizonepeta.

Further, the vitamins include vitamin B₁Vitamin B₃Vitamin B₆D-biotin and vitamin B₁₂One or more of (a).

Further, the amino acid comprises arginine and taurine, and the weight ratio of the arginine to the taurine is 1: 1-3.

Further, the probiotic is bacillus subtilis.

A preparation method of an additive for improving the organism immunity of livestock and poultry comprises the following steps:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) putting the traditional Chinese medicine powder in the step (1) into a sealed tank, uniformly spraying a mixed solvent, introducing water vapor,maintaining the pressure at 5-7MPa and 100-105 deg.C for 10-30s, removing the pressure, and mixing the solvent with NaHCO₃Ethanol and water, NaHCO₃The mass fraction of the traditional Chinese medicine is 0.1-0.3 wt%, the volume fraction of ethanol is 70-80%, the rest is water, and the mass ratio of the traditional Chinese medicine powder to the mixed solvent is 30-40: 1;

(3) dissolving the traditional Chinese medicine powder treated in the step (2) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 30-40%, and the material-liquid ratio is 1: 20-30, the ultrasonic power is 80-100W, the temperature is 40-50 ℃, and the extraction time is 30-40 min;

(4) extracting, filtering with membrane, spray drying to obtain Chinese medicinal extract, adding saccharicterpenin, amino acids, vitamins and probiotics, and mixing.

The invention has the beneficial effects that:

the usage and dosage are as follows: in high-temperature seasons, the product can be mixed with 1 ton of materials for every 2Kg and 1Kg of Baiyikang, so that the occurrence of high fever can be effectively controlled. 2kg of the product is added into 1 ton of feed for 5-7 days, or 1kg of the product is added into each ton of feed if the product is added for a long time; mixing and drinking: 1kg of the product is added into 1 ton of water for 5-7 days.

The additive can comprehensively improve the immunity and the tolerance of the organism, block the vicious circle of a plurality of pathological links, fully embody the integral treatment advantages of multi-path absorption, multi-component action, multi-target treatment and multi-link adjustment of the traditional Chinese medicine, and play a good role in preventing the disease before the disease is prevented, namely preventing the disease from changing, treating the disease before the disease is treated and treating both the symptoms and root causes.

The feed additive of the invention is rich in various Chinese medicine refined extract components and plant polysaccharide, can improve the function of inducing interferon by white blood cells, improve the contents of lgA and lgG of local infected parts, and can obviously increase the number of white blood cells and multinuclear white blood cells. Promoting cell regeneration and repair, maintaining normal intestinal flora, influencing nutrient utilization, improving the tolerance of organisms to environmental changes, remarkably resisting fatigue, enhancing the anti-stress capability of the organisms to cold and summer heat, promoting the utilization of nutrient substances and the like.

The method has the following specific beneficial effects:

1) has good prevention and rehabilitation effects on various viral diseases and immunosuppressive diseases (such as livestock blue ear disease, circovirus disease, pseudorabies, swine influenza, plague, pox, encephalomyelitis, etc.);

2) has good effects of preventing and recovering various respiratory diseases (livestock gastroenteritis, diarrhea, watery diarrhea, dyspepsia, yellow and white dysentery, side injury, milk-derived diarrhea, etc.);

3) has good effects of preventing and recovering other bacterial diseases (livestock gastroenteritis, diarrhea, watery diarrhea, dyspepsia, yellow and white dysentery, side injury, milk-derived diarrhea, etc.);

4) the compound feed has good prevention and recovery effects on urogenital system infection (such as prenatal and postnatal fever, endometritis, mastitis, prenatal and postnatal non-eating, agalactia syndrome, abortion, repeated mating infertility and the like of livestock), can purify diseases such as sow reproductive disorders, sow toxic syndrome and the like by using sows in the whole process or before sow mating, in the early stage of pregnancy (20 days), in the middle stage of pregnancy (60 days), in the later stage of pregnancy (90 days) and continuously using for 7-10 days, and can effectively purify the viruses carried by boars by using the compound feed every 30 days for 7 days; the disease resistance of the boars is improved, the semen quality is improved, and the source of horizontal infection of the whole pig farm is cut off;

5) has good effects of inhibiting mould, decomposing mycotoxin, protecting feed quality and removing and adsorbing mycotoxin.

7) Replenishing qi to invigorate the spleen, promoting the carbohydrate metabolism of the organism, accelerating the synthesis of protein and enzyme of the organism, promoting the growth of animals, promoting the growth and increment of bifidobacterium and lactobacillus, regulating the micro-ecological balance of intestinal tracts of the animals, promoting the digestion and absorption of nutrient substances and improving the utilization rate of feed;

8) tranquilization, anti-stress, reducing stress reaction of swinery when the swinery is changed and the disease is high, and improving the production performance of the swinery;

9) the egg-laying poultry or breeding poultry can be used for 3-5 days per month, the resistance of the poultry can be obviously enhanced, the hatching egg qualification rate is improved, and the broiler chicken and meat duck can be drunk for 2-3 days every 10 days, so that various viral diseases can be effectively prevented.

The additive prepared by the invention has the advantages of small effective dose, strong activity, good absorbability, high solubility, good absorbability, slow elimination and less loss of effective components; through the superfine grinding to traditional chinese medicine combination, utilize subsequent traditional chinese medicine extraction, through the processing to the high temperature high pressure cooperation mixed solvent of traditional chinese medicine powder, high temperature high pressure is used for making traditional chinese medicine powder inner structure inflation, and the mixed solvent who sprays simultaneously in advance gets into the inside of traditional chinese medicine powder, under the condition of guaranteeing the extraction rate, is favorable to shortening the time of ultrasonic extraction, and 2/3 has been shortened in the time of ultrasonic extraction, has reduced membrane filtration, spray drying's work load simultaneously, improves production efficiency.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.

Example one

An additive for improving the immunity of livestock and poultry organisms is prepared from the following raw materials in parts by weight: 18 parts of traditional Chinese medicine composition, 15 parts of saccharicterpenin, 8 parts of amino acid, 6 parts of vitamin and 10 parts of probiotics.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 8 parts of liquorice, 10 parts of astragalus membranaceus, 3 parts of ash bark, 1 part of ginseng, 13 parts of eucommia ulmoides, 5 parts of medlar, 6 parts of fermented soybean, 0.5 part of mint, 5 parts of burdock, 15 parts of epimedium herb, 2 parts of codonopsis pilosula, 15 parts of acanthopanax, 3 parts of scutellaria baicalensis, 15 parts of dried orange peel and 10 parts of schizonepeta.

The vitamins include vitamin B₁And D-biotin, vitamin B₁And D-biotin in a mass ratio of 1: 1.

The amino acid comprises arginine and taurine, and the weight ratio of the arginine to the taurine is 1: 1.

The probiotic is bacillus subtilis.

A preparation method of an additive for improving the organism immunity of livestock and poultry comprises the following steps:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) putting the traditional Chinese medicine powder in the step (1) into a sealed tank, uniformly spraying a mixed solvent, introducing water vapor, keeping the pressure for 30s under the conditions that the vapor pressure is 5MPa and the temperature is 100 ℃, removing the pressure, wherein the mixed solvent comprises NaHCO₃Ethanol and water, NaHCO₃The mass fraction of the traditional Chinese medicine powder is 0.1 wt%, the volume fraction of the ethanol is 80%, the rest is water, and the mass ratio of the traditional Chinese medicine powder to the mixed solvent is 40: 1;

(3) dissolving the traditional Chinese medicine powder treated in the step (2) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 40%, and the material-liquid ratio is 1: 20, the ultrasonic power is 100W, the temperature is 50 ℃, and the extraction time is 30 min;

(4) extracting, filtering with membrane, spray drying to obtain Chinese medicinal extract, adding saccharicterpenin, amino acids, vitamins and probiotics, and mixing.

Example two

An additive for improving the immunity of livestock and poultry organisms is prepared from the following raw materials in parts by weight: 15 parts of traditional Chinese medicine composition, 10 parts of saccharicterpenin, 5 parts of amino acid, 2 parts of vitamin and 5 parts of probiotics.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12 parts of honeysuckle, 5 parts of liquorice, 13 parts of astragalus, 2 parts of ash bark, 0.5 part of ginseng, 15 parts of eucommia bark, 1 part of medlar, 8 parts of fermented soybean, 1 part of mint, 2 parts of burdock, 10 parts of epimedium herb, 0.5 part of codonopsis pilosula, 5 parts of acanthopanax, 1 part of scutellaria, 10 parts of dried orange peel and 12 parts of schizonepeta.

The vitamins include vitamin B₁Vitamin B₃Vitamin B₆D-biotin and vitamin B₁₂One or more of (a).

The amino acid comprises arginine and taurine, and the weight ratio of the arginine to the taurine is 1: 1-3.

The probiotic is bacillus subtilis.

A preparation method of an additive for improving the organism immunity of livestock and poultry comprises the following steps:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) putting the traditional Chinese medicine powder in the step (1) into a sealed tank, uniformly spraying a mixed solvent, introducing water vapor, keeping the pressure for 20s under the conditions that the steam pressure is 6MPa and the temperature is 103 ℃, removing the pressure, wherein the mixed solvent comprises NaHCO₃Ethanol and water, NaHCO₃The mass fraction of the traditional Chinese medicine powder is 0.2 wt%, the volume fraction of the ethanol is 75%, the rest is water, and the mass ratio of the traditional Chinese medicine powder to the mixed solvent is 35: 1;

(3) dissolving the traditional Chinese medicine powder treated in the step (2) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 35%, and the material-liquid ratio is 1: 25, the ultrasonic power is 90W, the temperature is 45 ℃, and the extraction time is 35 min;

(4) extracting, filtering with membrane, spray drying to obtain Chinese medicinal extract, adding saccharicterpenin, amino acids, vitamins and probiotics, and mixing.

EXAMPLE III

An additive for improving the immunity of livestock and poultry organisms is prepared from the following raw materials in parts by weight: 20 parts of traditional Chinese medicine composition, 13 parts of saccharicterpenin, 10 parts of amino acid, 8 parts of vitamin and 8 parts of probiotics.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of honeysuckle, 10 parts of liquorice, 15 parts of astragalus, 5 parts of ash bark, 2 parts of ginseng, 10 parts of eucommia bark, 3 parts of medlar, 4 parts of fermented soybean, 0.7 part of mint, 3 parts of burdock, 13 parts of epimedium herb, 1 part of codonopsis pilosula, 10 parts of acanthopanax, 5 parts of scutellaria baicalensis, 20 parts of dried orange peel and 15 parts of schizonepeta.

The vitamins include vitamin B₁Vitamin B₃Vitamin B₆D-biotin and vitamin B₁₂One or more of (a).

The amino acid comprises arginine and taurine, and the weight ratio of the arginine to the taurine is 1: 1-3.

The probiotic is bacillus subtilis.

A preparation method of an additive for improving the organism immunity of livestock and poultry comprises the following steps:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) putting the traditional Chinese medicine powder in the step (1) into a sealed tank, uniformly spraying a mixed solvent, introducing water vapor, keeping the pressure for 10s under the conditions that the steam pressure is 7MPa and the temperature is 105 ℃, removing the pressure, wherein the mixed solvent comprises NaHCO₃Ethanol and water, NaHCO₃The mass fraction of the traditional Chinese medicine powder is 0.3 wt%, the volume fraction of the ethanol is 70%, the rest is water, and the mass ratio of the traditional Chinese medicine powder to the mixed solvent is 30: 1;

(3) dissolving the traditional Chinese medicine powder treated in the step (2) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 30%, and the material-liquid ratio is 1: 30, the ultrasonic power is 80W, the temperature is 40 ℃, and the extraction time is 40 min;

(4) extracting, filtering with membrane, spray drying to obtain Chinese medicinal extract, adding saccharicterpenin, amino acids, vitamins and probiotics, and mixing.

The addition amount of the composition is 0.2% for treating diarrhea

The big group of pigs in a certain pig farm have continuous diarrhea for more than 1 week, the weight is 45-50 jin/head, the number of the control group is 118, the experimental group adopts the additive prepared in the third embodiment, and the control group adopts furazolidone, florfenicol, enrofloxacin and sulfadiazine for treatment, which are mostly ineffective; the experimental group is added with 2 Kg/ton of the additive prepared in the third example, the majority of the treatment is cured after 3 days, and the experimental data are shown in the table 1.

TABLE 1 therapeutic effect of diarrhea

	Number of heads	Number of diarrhea	Number of heads cured	Cure rate
					Control group	118	118	48	40.7％
EXAMPLE III	120	120	115	96％

0.25% of the composition can be added for treating respiratory diseases mainly caused by' blue ear disease

200 weaned piglets are introduced from a certain province and fed for more than one month, respiratory diseases occur, the weight is about 60 jin, most of the control groups are treated by using the mycoplasma, the amoxicillin, the doxycycline, the florfenicol, the sulfamonomethoxine and the like, the curative effect is not obvious, 2.5 kg/ton of the additive prepared in the third embodiment is added into the test group, most of the weaned piglets are cured after 10 days, and the test data are shown in table 2.

TABLE 2 therapeutic effect of respiratory tract diseases

	Number of heads	The number of the head with asthma and cough	Number of heads cured	Cure rate
					Control group	60	43	18	41.9％
EXAMPLE III	60	45	43	95.6％

The specific effects of the application test on the influence of the lactation and survival growth performance of the lactating sows are shown in Table 3.

TABLE 3 Effect of influence on lactation and survival growth performance of lactating sows

As can be seen from table 3, the additive of the present invention can effectively avoid the endometritis-mastitis-agalactia triple feature of postpartum sows; improving average weaning litter weight, average daily gain at 0-28 days of age, weaning weight at 28 days of age, etc.

Comparative example 1

This embodiment is basically the same as the third embodiment, except that: a preparation method of an additive for improving the organism immunity of livestock and poultry comprises the following steps:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) dissolving the traditional Chinese medicine powder treated in the step (1) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 30%, and the material-liquid ratio is 1: 30, performing ultrasonic treatment 3 times at the ultrasonic power of 80W and the temperature of 40 ℃ for extraction time of 40min, and respectively taking 3 times of extraction liquid;

(3) after extraction, membrane filtration and spray drying are adopted to obtain the traditional Chinese medicine extract.

Comparative example No. two

This embodiment is basically the same as the third embodiment, except that: NaHCO is removed in step (2)₃。

After the ultrasonic extraction in the step (2) of the comparative example is completed once, the extract liquid is taken, membrane filtration and spray drying are carried out, the obtained traditional Chinese medicine extract is 30.24% of the traditional Chinese medicine extract in the third embodiment, and after the extract liquid of the last two times is combined, membrane filtration and spray drying are carried out, so that the total sum of the traditional Chinese medicine extract obtained by 3 times of extraction is basically the same as that of the traditional Chinese medicine extract in the third embodiment.

Comparative example two removal of NaHCO₃The obtained traditional Chinese medicine extract is 78.32% of the third embodiment.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (6)

1. The additive for improving the immunity of the livestock and poultry is characterized by being prepared from the following raw materials in parts by weight: 15-20 parts of traditional Chinese medicine composition, 10-15 parts of saccharicterpenin, 5-10 parts of amino acid, 2-8 parts of vitamin and 5-10 parts of probiotics.

2. The additive for improving the immunity of the livestock and poultry bodies according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-15 parts of honeysuckle, 5-10 parts of liquorice, 10-15 parts of astragalus, 2-5 parts of ash bark, 0.5-2 parts of ginseng, 10-15 parts of eucommia bark, 1-5 parts of medlar, 4-8 parts of fermented soybean, 0.5-1 part of mint, 2-5 parts of burdock, 10-15 parts of epimedium herb, 0.5-2 parts of codonopsis pilosula, 5-15 parts of acanthopanax, 1-5 parts of scutellaria baicalensis, 10-20 parts of dried orange peel and 10-15 parts of schizonepeta.

3. The additive for improving the immunity of livestock and poultry according to claim 1, wherein the vitamins comprise vitamin B₁Vitamin B₃Vitamin B₆D-biotin and vitamin B₁₂One or more of (a).

4. The additive for improving the immunity of the organisms of the livestock and the poultry according to one of claims 1 to 3, wherein the amino acid comprises arginine and taurine, and the weight ratio of the arginine to the taurine is 1: 1-3.

5. The additive for improving the immunity of the livestock and poultry body according to claim 1, wherein the probiotic is bacillus subtilis.

6. A process for the preparation of the additive according to any one of claims 1 to 5, comprising the steps of:

(1) micronizing the Chinese medicinal composition to obtain Chinese medicinal powder with particle size less than 500 meshes;

(2) putting the traditional Chinese medicine powder in the step (1) into a sealed tank, uniformly spraying a mixed solvent, introducing water vapor, keeping the pressure for 10-30s under the conditions that the vapor pressure is 5-7MPa and the temperature is 100-105 ℃, and removing the pressure, wherein the mixed solvent comprises NaHCO₃Ethanol and water, NaHCO₃The mass fraction of the traditional Chinese medicine is 0.1-0.3 wt%, the volume fraction of ethanol is 70-80%, the rest is water, and the mass ratio of the traditional Chinese medicine powder to the mixed solvent is 30-40: 1;

(3) dissolving the traditional Chinese medicine powder treated in the step (2) in an ethanol aqueous solution for ultrasonic extraction, wherein the volume fraction of ethanol in the ethanol aqueous solution is 30-40%, and the material-liquid ratio is 1: 20-30, the ultrasonic power is 80-100W, the temperature is 40-50 ℃, and the extraction time is 30-40 min;

(4) extracting, filtering with membrane, spray drying to obtain Chinese medicinal extract, adding saccharicterpenin, amino acids, vitamins and probiotics, and mixing.