CN110478429B - Traditional Chinese medicine composition for treating zearalenone poisoning of livestock and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating zearalenone poisoning of livestock and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating zearalenone poisoning of livestock and a preparation method thereof. The traditional Chinese medicine composition is prepared by extracting astragalus, white paeony root, prepared rhizome of rehmannia, bighead atractylodes rhizome, cimicifuga foetida and radix ophiopogonis according to a certain proportion. The invention takes strengthening body resistance and eliminating evil, tonifying qi and yang, nourishing yin and blood and consolidating constitution as the rules of treatment, can efficiently eliminate zearalenone toxin, relieve the damage of the toxin to the animal body and improve the production performance of animals.
Description
(I) technical field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for treating zearalenone poisoning of livestock and a preparation method thereof.
(II) background of the invention
Currently, the food crops in China are low in scale degree, and the mildew-proof awareness of the crops in the processing, transportation and storage links is low, so that the mycotoxin detection rate of related crop products is high, and the content of the mycotoxin is far higher than the average level of developed countries. According to investigation and research of Gong' a Jolon et al in 2017, the detection rate of Zearalenone (ZEA) in the detection of mycotoxin in feed raw materials or feeds in various places in China is up to 91.9% -100%, and the overproof rate shows an increasing trend. ZEA pollution not only causes huge waste of resources, but also seriously harms the stable development of animal husbandry in China, and even seriously threatens the public health safety.
The generation of mycotoxin in feed and feed raw materials is inevitable, the mildew-proof work is difficult to be completely effective, and various mildew-proof methods commonly used at present have certain defects. For example, the mildew removing agent widely used in the market at present is mainly a hydrated aluminosilicate adsorbent, but the adsorptive mildew removing method is only effective on aflatoxin and has poor effect on ZEA, and nutrient substances are easy to adsorb and can be desorbed in intestinal tracts. There are also studies related to the use of biological methods for mold removal treatment. The biological method mainly utilizes specific degrading enzymes to degrade mycotoxin, but has the problems that most of microorganisms producing degrading enzymes are livestock pathogenic bacteria, and secondary metabolites or degradation intermediate products of the microorganisms still have toxicity, low enzyme yield, unstable activity, complex separation and purification and the like. On the other hand, although the addition of the existing mold removal agent can adsorb and remove certain mycotoxin generated by mildew, the mycotoxin can poison the feed, the adsorbent is used for treating the feed after livestock eat the mildewed feed, the effect of the mycotoxin taken into the livestock is not obvious, the method ignores the immune suppression and other effects of the mycotoxin on organisms, the harm of the mycotoxin to the livestock is difficult to guarantee to eliminate, and the method belongs to the aspects of treatment and the root cause.
ZEA poisoning can cause vaginal prolapse, uterine prolapse, rectal prolapse, oestrus cycle disorder and gradual loss of pregnancy capability of sows; pregnant pigs can have the phenomena of abortion, stillbirth and the like; the young boars can suffer from orchitis, the quantity and quality of semen are reduced, and the like. Currently, no effective clinical treatment medicine exists for ZEA poisoning, so that a medicine which is purely natural, aims at the physiological characteristics and symptoms of livestock during disease onset and can fundamentally treat the disease is urgent.
Disclosure of the invention
In order to solve the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating zearalenone poisoning of livestock and a preparation method thereof. The prepared traditional Chinese medicine composition can remove Zearalenone (ZEA) toxin, treat various clinical symptoms caused by Zearalenone (ZEA) poisoning, make up for the defect of the traditional medicine for treating Zearalenone (ZEA) poisoning, simultaneously has the characteristics of improving the production performance of livestock, being suitable for the physiological structure of livestock and large-scale production, and is suitable for clinical popularization and application in multiple fields.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows.
A traditional Chinese medicine composition for treating zearalenone poisoning of livestock is characterized by comprising astragalus membranaceus, radix paeoniae alba, radix rehmanniae preparata, bighead atractylodes rhizome, rhizoma cimicifugae and radix ophiopogonis, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-40 parts of astragalus membranaceus, 50-70 parts of radix paeoniae alba, 5-20 parts of radix rehmanniae preparata, 15-35 parts of bighead atractylodes rhizome, 10-25 parts of rhizoma cimicifugae and 10-25 parts of radix ophiopogonis.
As a preferred scheme of the invention, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 55-70 parts of radix paeoniae alba, 5-15 parts of radix rehmanniae preparata, 20-30 parts of bighead atractylodes rhizome, 12-20 parts of rhizoma cimicifugae and 12-20 parts of radix ophiopogonis.
As a preferred scheme of the invention, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts of astragalus, 55 parts of white paeony root, 5 parts of prepared rhizome of rehmannia, 20 parts of largehead atractylodes rhizome, 12 parts of largetrifoliolioliolious bugbane rhizome and 12 parts of dwarf lilyturf tuber.
As a preferred scheme of the invention, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 26 parts of astragalus, 65 parts of white paeony root, 10 parts of prepared rhizome of rehmannia, 25 parts of largehead atractylodes rhizome, 13 parts of largetrifolioliolious bugbane rhizome and 13 parts of dwarf lilyturf tuber.
The traditional Chinese medicine composition for treating zearalenone poisoning of livestock can be used in the fields of medicines, feeds, feed additives and the like. It is characterized by comprising a pharmaceutically acceptable carrier or common feed auxiliary materials. The drugs, feeds and feed additives may be prepared according to any conventional method in the art. The preparation forms of the medicament comprise oral liquid, powder, granules, powder and superfine powder.
When the traditional Chinese medicine composition for treating zearalenone poisoning of livestock is used for preparing medicines, feeds and feed additives, 1-99% of the traditional Chinese medicine composition can be mixed with 1-99% of pharmaceutically acceptable carriers or auxiliary materials according to the weight ratio.
Therefore, another object of the present invention is to provide a method for preparing the above-mentioned Chinese medicinal composition, comprising the following steps:
the Chinese medicinal composition or medicament of the invention can be prepared by any conventional method in the field. Preferably, the preparation method comprises the following steps:
1. weighing 6 medicinal materials of astragalus, white paeony root, prepared rehmannia root, largehead atractylodes rhizome, largetrifoliolioliolioliolioliolious bugbane rhizome and dwarf lilyturf tuber according to the required weight parts;
2. adding water which is 8-12 times of the total weight of the medicinal materials, decocting for 3 times, each time for 1.5 hours, filtering, combining the filtrates, concentrating under vacuum and negative pressure until the relative density is 1.02-1.15 (65 ℃), and preparing the corresponding preparation according to the preparation process of the required preparation.
The use method and the dosage of the traditional Chinese medicine composition are as follows: the dosage of the invention depends on the specific dosage form and the degree of zearalenone poisoning of livestock.
As a guide: for powder, granule, powder and superfine powder, the powder is taken and mixed for use, the dosage is 0.5% (w/w), and the continuous use is for 5 days as a course of treatment and for 2 courses of treatment. For oral liquid, the liquid medicine is taken according to 0.5% (v/v), and is continuously used for 5 days as a treatment course, and is continuously used for 2 treatment courses.
The formula principle of the invention is as follows:
chinese veterinarians dialectically believe that the mycotoxin is a substance with the nature of yin cold, belongs to yin in yin, and easily loses yang qi of five internal organs of a body, particularly yang qi of spleen and kidney. Zearalenone toxin causes spleen and kidney yang deficiency. When spleen yang is deficient, it is unable to transport and transform food water, resulting in spleen yang being obstructed by dampness. Meanwhile, spleen yang deficiency causes sinking of middle qi, which is often accompanied by prolapse of viscera. Toxin is accumulated in the body and tends to injure the kidney yang, causing damage to the healthy qi of the body. Kidney yang governs yang qi of the whole body, and once injured, it cannot warm other organs, and directly affects reproductive function. The uterus belongs to the extraordinary fu-organ, and its function belongs to the kidney and thoroughfare and conception vessels. It is caused by the disorder of liver, kidney, spleen and stomach, weakness of transportation and transformation, and insufficient generation of qi and blood. The toxin causes liver damage, liver governs smoothing flow of qi, once liver qi stagnation results in abnormal smoothing flow of qi, and the detoxifying metabolism function and other aspects are obviously affected. Therefore, the invention adopts the treatment principle of strengthening body resistance and eliminating evil, tonifying qi and yang, nourishing yin and blood and consolidating the constitution, and lifting yang and sinking qi to treat the zearalenone poisoning.
Compared with the existing prescription and adsorbent for treating zearalenone poisoning of livestock, the invention has the following advantages:
1. the preparation method of the invention is simple, safe and reliable, and has significant curative effect and no side effect.
2. The invention takes strengthening body resistance and eliminating evil, tonifying qi and strengthening yang, nourishing yin and blood and consolidating constitution as the rules of treatment, the selection and the dosage of the medicines in the prescription are scientifically and reasonably researched by systematic pharmacodynamics, and the invention has obvious effect on treating zearalenone poisoning of livestock.
3. The invention is a pure Chinese medicinal preparation, does not contain chemical drugs and antibiotics, has no toxicity, no drug residue and environmental protection.
4. The traditional Chinese medicine composition is prepared on the basis of the theories of traditional Chinese medicine and Chinese veterinarian, is different from the prior art that only mould and mycotoxin are adsorbed and only clinical symptoms are treated, and achieves the aim of completely curing by removing causes through treatment of symptoms.
5. The invention can improve the immunity of the organism and the production performance while curing diseases.
(IV) detailed description of the preferred embodiments
For a better understanding and an enabling description of the present invention, reference will now be made to the following examples which are set forth in order to provide a further understanding of the invention.
Example 1: a Chinese medicinal composition for treating livestock zearalenone poisoning comprises the following medicinal materials: 40 parts of astragalus membranaceus, 70 parts of radix paeoniae alba, 20 parts of prepared rehmannia root, 35 parts of bighead atractylodes rhizome, 25 parts of rhizoma cimicifugae and 25 parts of radix ophiopogonis, 12 times of water is added, the decoction is carried out for 3 times, each time of decoction is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, vacuum negative pressure concentration is carried out until the relative density is 1.10(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours, the filtration is carried out again, the filtrate is added with water and adjusted to 1000mL, and the.
Example 2: a Chinese medicinal composition for treating livestock zearalenone poisoning comprises the following medicinal materials: 20 parts of astragalus membranaceus, 55 parts of radix paeoniae alba, 5 parts of radix rehmanniae preparata, 20 parts of bighead atractylodes rhizome, 12 parts of cimicifugae foetidae and 12 parts of radix ophiopogonis, 12 times of water is added, the decoction is carried out for 3 times, each decoction is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, vacuum negative pressure concentration is carried out until the relative density is 1.02(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours, the filtration is carried out again, the filtrate is added with water and adjusted to 1000mL, and the.
Example 3: a Chinese medicinal composition for treating livestock zearalenone poisoning comprises the following medicinal materials: 26 parts of astragalus membranaceus, 65 parts of radix paeoniae alba, 10 parts of radix rehmanniae preparata, 25 parts of bighead atractylodes rhizome, 13 parts of cimicifugae foetidae and 13 parts of radix ophiopogonis, 12 times of water is added, the decoction is carried out for 3 times, each time of decoction is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, vacuum negative pressure concentration is carried out until the relative density is 1.05(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours, the filtration is carried out again, the filtrate is added with water and adjusted to 1000 mL.
Example 4: a Chinese medicinal composition for treating livestock zearalenone poisoning comprises the following medicinal materials: 15 parts of astragalus membranaceus, 50 parts of radix paeoniae alba, 5 parts of radix rehmanniae preparata, 15 parts of bighead atractylodes rhizome, 10 parts of rhizoma cimicifugae and 10 parts of radix ophiopogonis, 10 times of water is added, the decoction is carried out for 3 times, each decoction is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, vacuum negative pressure concentration is carried out until the relative density is 1.15(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours, the filtration is carried out again, the filtrate is added with water and adjusted to 1000mL, and the traditional Chinese.
Example 5: the formula is optionally carried out without following the relationship of the weight parts of the medicaments in the formula: 60 parts of astragalus membranaceus, 30 parts of radix paeoniae alba, 30 parts of radix rehmanniae preparata, 5 parts of bighead atractylodes rhizome, 30 parts of rhizoma cimicifugae and 30 parts of radix ophiopogonis, 10 times of water is added, the decoction is carried out for 3 times, each time is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, vacuum negative pressure concentration is carried out until the relative density is 1.15(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours, the filtration is carried out again, the filtrate is added with water and adjusted to 1000mL, and the traditional Chinese.
Example 6: the formula is optionally carried out without following the proportion relationship of the medicaments in the formula: 60 parts of astragalus membranaceus, 60 parts of bighead atractylodes rhizome and 30 parts of divaricate saposhnikovia root, 10 times of water is added, the decoction is carried out for 3 times, each time of decoction is carried out for 1.5 hours, the filtration is carried out, the filtrates are combined, the vacuum negative pressure concentration is carried out until the relative density is 1.15(65 ℃), 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate are added, the mixture is uniformly mixed, the mixture is kept stand at 4 ℃ for 12 hours and is filtered again, the filtrate is added with water and is adjusted to 1000mL, and the traditional Chinese medicine oral liquid for treating.
Example 7: the formula is carried out according to the components of the decoction for tonifying middle-jiao and Qi without following the proportion relationship of the medicines in the formula: 15 parts of astragalus, 15 parts of codonopsis pilosula, 10 parts of bighead atractylodes rhizome, 15 parts of honey-fried licorice root, 10 parts of angelica, 6 parts of dried orange peel, 6 parts of cimicifuga foetida, 12 parts of radix bupleuri, 9 parts of ginger and 6 parts of Chinese date. Adding 10 times of water, decocting for 3 times, each time decocting for 1.5h, filtering, mixing filtrates, vacuum concentrating to relative density of 1.15(65 deg.C), adding 0.5% (w/v) potassium sorbate and 0.5% (w/v) sodium benzoate, mixing, standing at 4 deg.C for 12h, filtering again, adding water into filtrate to adjust to 1000mL, sterilizing, and bottling to obtain the Chinese medicinal oral liquid for treating zearalenone poisoning of livestock.
Comparative example 1: the main component of the commercial mold remover product is hydrated aluminosilicate, and the mold remover product is mixed into feed according to the addition amount of 0.1 percent for use.
Comparative example 2: the main components of the commercial biological degermed antidote product are lactobacillus plantarum, saccharomyces cerevisiae, yeast cell wall, bacillus subtilis and mycotoxin specific degrading enzyme. Mixing with feed at an amount of 0.1%.
Comparative example 3: according to a prescription for pig zearalenone poisoning in a veterinary prescription manual (3 rd edition) published by 2013 Chinese agriculture press, 20g of liquorice, 10g of radix ophiopogonis and 15g of poria cocos are taken, decocted with water to obtain a decoction, cooled, added with 2 fresh eggs and 30g of brown sugar, and mixed to obtain the traditional Chinese medicine composition. The preparation is administered 3 times per day.
Clinical trial
1. Test animals: 100 parturient sows with similar gestation times and similar body weights and having ZEA poisoning and parturient manifestations (red vulva, swelling and increased secretion) are selected, wherein the history of feeding the mouldy feed polluted by zearalenone is similar. After quantitative detection, the zearalenone toxins with high concentration are contained, and the toxicity of the zearalenone toxins is confirmed to be diagnosed.
2. Test drugs: test pigs were randomly divided into 10 groups and kept in isolation. Test groups 1 to 7, using the drugs prepared in examples 1 to 7, respectively; the drugs prepared in comparative examples 1 to 3 were used in test groups 8 to 10.
3. The treatment method comprises the following steps: during the experiment, the normal pollution-free feed is replaced for feeding, and all pigs are fed and managed under the same nutrition level and management condition. In examples 1 to 7, the drug is administered with 0.5% (v/v) of water for 5 days as a treatment course and 2 treatment courses. Comparative examples 1 to 2 were used in the form of a feed in an amount of 0.1% by weight. Comparative example 3 was taken for drenching.
4. The therapeutic effect judgment standard is as follows:
(1) none: the vulva has no symptoms, and is marked as "-".
(2) Slight: the vulva has very slight and hardly noticeable symptoms, and does not affect daily activities, feed intake and weight gain, and is marked as "+".
(3) Medium: the vulva observed mild symptoms, but had no major interference with normal daily activities and productivity, and was noted as "+".
(4) Slightly more: the vulva had obvious symptoms observed, which interfered with daily activities and productivity, and was marked as "+ + + +".
(5) Severe: the vulva has severe symptoms, which greatly interfere with daily activities and productivity, and affect the productivity, and is marked as +++.
5. Detection indexes are as follows:
(1) oestrus rate of weaned sows: sows which have oestrous and bred within 15 days after weaning account for the number of the total sows.
(2) Postweaning estrus interval: refers to the time interval from weaning to oestrus of the sow.
(3) Red and swollen vulva of sow and secretion.
(4) Average number born alive, average weight of piglets, weaning age of piglets in days, average weight of weaning and the like.
TABLE 1 influence of different administration groups on the production performance of ZEA poisoned antenatal sow
Note: in comparison to the columns, the difference in the shoulder letters indicates significant difference (P <0.05), and the inclusion of the same letter or no letter indicates insignificant difference (P > 0.05).
Test results show that the treatment effects of the embodiments 1 to 5 are better than those of other embodiments and comparative examples, wherein the treatment effect of the embodiment 3 is the best, and the treatment effect, the recovery of the production performance and the production benefit index of the clinical symptoms of the sow are all good, and the effect is the best.
The foregoing shows and describes the fundamental principles of the invention, together with the principal technical features and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are intended to illustrate the principles of the invention, but rather, various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (6)
1. A traditional Chinese medicine composition for treating zearalenone poisoning of livestock is characterized by being prepared from astragalus membranaceus, radix paeoniae alba, radix rehmanniae preparata, bighead atractylodes rhizome, rhizoma cimicifugae and radix ophiopogonis, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-40 parts of astragalus membranaceus, 50-70 parts of radix paeoniae alba, 5-20 parts of radix rehmanniae preparata, 15-35 parts of bighead atractylodes rhizome, 10-25 parts of rhizoma cimicifugae and 10-25 parts of radix ophiopogonis.
2. The traditional Chinese medicine composition for treating zearalenone poisoning of livestock according to claim 1, which is characterized by comprising the following components in parts by weight: 20-26 parts of astragalus membranaceus, 55-65 parts of radix paeoniae alba, 5-10 parts of radix rehmanniae preparata, 20-25 parts of bighead atractylodes rhizome, 12-15 parts of rhizoma cimicifugae and 12-15 parts of radix ophiopogonis.
3. The traditional Chinese medicine composition for treating zearalenone poisoning of livestock according to claim 1 or 2, characterized in that, calculated by weight parts: 26 parts of astragalus, 65 parts of white paeony root, 10 parts of prepared rhizome of rehmannia, 25 parts of largehead atractylodes rhizome, 13 parts of largetrifolioliolious bugbane rhizome and 13 parts of dwarf lilyturf tuber.
4. The traditional Chinese medicine composition for treating zearalenone poisoning of livestock according to claim 1 or 2, characterized in that, calculated by weight parts: 20 parts of astragalus, 55 parts of white paeony root, 5 parts of prepared rhizome of rehmannia, 20 parts of largehead atractylodes rhizome, 12 parts of largetrifoliolioliolious bugbane rhizome and 12 parts of dwarf lilyturf tuber.
5. The method for preparing a Chinese medicinal composition for treating zearalenone poisoning of livestock according to any one of claims 1 to 4, wherein: weighing 6 medicinal materials including astragalus, white paeony root, prepared rehmannia root, bighead atractylodes rhizome, largetrifolioliolious bugbane rhizome and dwarf lilyturf tuber according to the required weight parts, adding water which is 8-12 times of the total weight of the medicinal materials, decocting for 3 times, decocting for 1.5h each time, filtering, combining filtrates, concentrating under vacuum and negative pressure to the relative density of 1.02-1.15 at 65 ℃, and preparing the corresponding preparation according to the preparation process of the required preparation.
6. The use of the Chinese medicinal composition of any one of claims 1 to 4 in the preparation of a medicament, feed or feed additive for preventing and treating zearalenone poisoning of livestock.
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| CN1251268A (en) * | 1999-09-23 | 2000-04-26 | 林海红 | Fodder additive for milch livestock |
| CN102068604A (en) * | 2009-11-20 | 2011-05-25 | 康怡科技药业制造厂 | Modified angelica sinensis blood enriching preparation and application and preparation method thereof |
| CN106924352A (en) * | 2015-12-31 | 2017-07-07 | 洛阳惠中兽药有限公司 | A kind of application of Chinese medicine composition |
| CN109893564A (en) * | 2019-03-19 | 2019-06-18 | 山东畜牧兽医职业学院 | Improve the Chinese medicinal formulae and preparation method thereof of lactating cow production performance |
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|---|---|---|---|---|
| CN1251268A (en) * | 1999-09-23 | 2000-04-26 | 林海红 | Fodder additive for milch livestock |
| CN102068604A (en) * | 2009-11-20 | 2011-05-25 | 康怡科技药业制造厂 | Modified angelica sinensis blood enriching preparation and application and preparation method thereof |
| CN106924352A (en) * | 2015-12-31 | 2017-07-07 | 洛阳惠中兽药有限公司 | A kind of application of Chinese medicine composition |
| CN109893564A (en) * | 2019-03-19 | 2019-06-18 | 山东畜牧兽医职业学院 | Improve the Chinese medicinal formulae and preparation method thereof of lactating cow production performance |
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