CN111568942A - Functional additive for blue-ear disease and preparation method thereof - Google Patents
Functional additive for blue-ear disease and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a functional additive for treating porcine reproductive and respiratory syndrome and a preparation method thereof, belonging to the technical field of veterinary drugs, and the functional additive comprises the following raw materials in parts by weight: 10-15 parts of acanthopanax, 10-15 parts of eucommia, 10-15 parts of astragalus, 5-10 parts of ginseng leaf, 5-10 parts of liquorice, 10-15 parts of isatis root, 10-15 parts of honeysuckle and 3-5 parts of toad extract; the functional additive has the advantages that the effective components are not easily damaged, the medicinal effect is rapid, the preventive and therapeutic effects on the porcine reproductive and respiratory syndrome can be effectively realized, the fermented medicine dregs are used as the medicinal matrix, the problem of medicine dregs waste is solved, and the functional additive is green, environment-friendly and free of medicament resistance.
Description
Technical Field
A functional additive for treating a blue-ear disease and a preparation method thereof belong to the technical field of veterinary drugs, and particularly relate to the technical field of treatment of the blue-ear disease.
Background
Porcine reproductive and respiratory syndrome, swine mystery disease and the like are viral infectious diseases of pigs and are mainly characterized by abortion, stillbirth, mummy, weak fetus and respiratory disturbance. Clinical symptoms pregnant sows are mainly seen in sows of more than 100 days in gestation period, particularly 107-112 days, and show sudden anorexia, respiratory symptoms such as sneezing, cough and the like of the sows can appear, the sows also can have high body temperature, but the sows usually do not have high residual heat. In severe cases, depression and dyspnea occur, and the ear tip and the ear margin are bluish purple due to dyspnea and anoxia, so the disease is called 'blue-ear disease'. Infected pregnant sows suffer from lassitude, poor appetite, temporary high body temperature, cough, dyspnea of various degrees, abnormal oestrus or infertility, premature birth of pregnant sows, abortion, stillbirth, abnormal fetus, weak fetus and the like. The incidence of disease of piglets in infected pig farms can reach 100%, the mortality can reach more than 50%, the abortion rate of sows can reach more than 30%, infected fattening pigs can also die, nonpregnant sows and breeding boars can also be infected, and symptoms such as anorexia, dyspnea, cough, fever and the like also appear after infection.
At present, two main directions are provided for preventing and treating the blue-ear pig disease, one is vaccination, prevention and treatment are carried out by combining the modes of adding medicines and mixing materials in feed in the later period and disinfecting the environment, but the effect is general and the cost is high; second, western medicine prevention and treatment, but the use of western medicine is abused to bring great potential safety hazard to pork meat products, and the medicine residue has become one of the main factors influencing the safety of pork products; therefore, the research and development of the functional additive for the blue-ear disease, which has low cost, no side effect and good effect, has very important practical significance.
Disclosure of Invention
The invention aims to: the functional additive for the blue-ear disease and the preparation method thereof are provided, the active ingredients of the functional additive are not easy to damage, the drug effect is rapid, the prevention and treatment effects on the blue-ear disease of the pig can be effectively achieved, the fermented medicine dregs are used as the drug property matrix, the problem of medicine dregs waste is solved, and the functional additive is green and environment-friendly and has no drug resistance.
The technical scheme adopted by the invention is as follows:
in order to achieve the aim, the invention provides a functional additive for treating blue-ear disease, which comprises the following raw materials in parts by weight:
10-15 parts of acanthopanax, 10-15 parts of eucommia, 10-15 parts of astragalus, 5-10 parts of ginseng leaf, 5-10 parts of liquorice, 10-15 parts of isatis root, 10-15 parts of honeysuckle and 3-5 parts of toad extract.
Preferably, the functional additive comprises the following raw material components in parts by weight: 15 parts of acanthopanax, 15 parts of eucommia, 15 parts of astragalus, 10 parts of ginseng leaf, 10 parts of liquorice, 10 parts of isatis root, 10 parts of honeysuckle and 4 parts of toad extract.
The pharmacological actions of the traditional Chinese medicine components are as follows:
acanthopanax senticosus, pungent, bitter, slightly sweet and warm in flavor, enters liver and kidney meridians. Has effects of dispelling pathogenic wind and removing dampness, nourishing liver and kidney, strengthening tendons and bones, and promoting blood circulation. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, debility, weakness, traumatic injury, fracture, edema, loempe, and pruritus vulvae.
Eucommia bark, cortex eucommiae, sweet in taste and warm in nature, enters liver and kidney meridians, tonifies liver and kidney, strengthens muscles and bones, and prevents miscarriage; has effects of nourishing liver and kidney, and treating soreness of waist and back, weakness of feet and knees, dribbling urination, pruritus vulvae due to damp, hypertension and miscarriage prevention. The eucommia bark and the acanthopanax root are compatible, so that the effects of strengthening muscles and bones, dispelling wind-damp, preventing miscarriage and treating liver and kidney deficiency are achieved, the phenomena of lassitude and body weakness of sows suffering from the blue-ear disease can be effectively relieved, the muscles and bones of the sows are strengthened, and the liver and the kidney are tonified.
The astragalus membranaceus is sweet in taste and slightly warm in nature, enters lung, spleen, liver and kidney channels, can tonify middle-jiao and Qi, has obvious curative effects on symptoms such as weakness of spleen and stomach, inappetence, poor appetite, loose stool, limb fatigue and weakness and the like, particularly has excellent effect on weakness of the hindquarter caused by highly pathogenic blue-ear disease, and contains the effective component of calycosin which can improve the immune function, has the effects of resisting bacteria and inhibiting viruses and improves the body performance of sows.
The ginseng leaves are cold in nature, bitter and sweet in taste, and can tonify qi, benefit lung, dispel summer heat and promote the production of body fluid. Can be used for treating cough due to qi deficiency, summer heat, dysphoria, thirst due to body fluid injury, blurred vision, and fatigue of limbs. The ginseng leaf and the astragalus root are matched to play the effects of supplementing qi and nourishing yin, relieving cough and reducing dryness, relieving body weakness and improving the immunity of the organism.
Licorice root, radix Glycyrrhizae is sweet in nature and flavor, neutral in nature, and enters heart, spleen, lung and stomach meridians. The liquorice is added, so that the effects of harmonizing the drug properties of the various medicines can be achieved, and the drug effects of the various medicines can be better and synergistically exerted.
The isatis root is bitter in taste, cold in nature and non-toxic, enters liver and stomach meridians, has the effects of clearing heat and removing toxicity, cooling blood and relieving sore throat, particularly can effectively relieve fever, anorexia or anorexia caused by the blue-ear disease of pigs, and simultaneously has the functions of inhibiting viruses and improving the immunity of sows.
The honeysuckle flower is pungent, slightly bitter and cold in nature, enters lung, stomach, heart and large intestine channels, is rich in chlorogenic acid, and improves the immune function of a body to virus susceptible cells by promoting the immune response mediated by T cells of the body and the activity of NK cells. The radix isatidis and the honeysuckle flower are matched to play a role in clearing heat and removing toxicity, can inhibit viruses, and simultaneously has an anti-endotoxin effect, so that other toxin infections caused by the sick pigs are effectively prevented.
The Bufo siccus extract has cold and bitter properties, and has effects of removing toxic substance, relieving swelling and pain, tonifying heart, promoting urination, resisting cancer, anesthesia, and resisting radiation, and can be used for treating heart failure, stomatitis, pharyngolaryngitis, laryngopharynx swelling and pain, and skin cancer.
The invention also provides a preparation method of the functional additive for blue ear disease, which comprises the following steps:
(1) cleaning and drying the traditional Chinese medicine raw materials, cutting into sections, sterilizing at the high temperature of 120-130 ℃ for 15 minutes, putting into a fermentation tank, adding pure water and strains, and fermenting at the constant temperature of 37 ℃ for 3-5 days;
(2) pouring out the fermented Chinese medicinal liquid, filtering, adding Bufo siccus extract, stirring, and concentrating to obtain paste;
(3) drying and crushing the fermented traditional Chinese medicine residues;
(4) and (3) uniformly mixing the paste obtained in the step (2) and the powder obtained in the step (3), drying, crushing again, and packaging to obtain a finished product.
Preferably, the adding amount of the pure water in the step (1) is 3-4 times of the weight of the traditional Chinese medicine raw materials.
Preferably, the adding amount of the strain in the step (1) is 0.01-0.2% of the total fermentation material mass.
Preferably, the strain in the step (1) is any one or any combination of yeast, bacillus subtilis and lactic acid bacteria.
Preferably, the powder obtained in the steps (3) and (4) is sieved by a sieve of 60-120 meshes.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. in the functional additive prepared by the invention, the acanthopanax and the eucommia are matched to effectively reduce the phenomena of lassitude and physical weakness of sick sows, strengthen the muscles and bones, and tonify the liver and the kidney; the ginseng leaf and the astragalus are matched to play the effects of supplementing qi and nourishing yin, relieving cough and reducing dryness, relieving body weakness and improving the immunity of the organism; the radix isatidis and the honeysuckle are matched to play a role in clearing heat and removing toxicity, so that the radix isatidis and the honeysuckle can play a role in inhibiting viruses, and simultaneously have an anti-endotoxin effect, so that other toxin infections caused by the sick pigs can be effectively prevented; the toad extract is added to achieve the effects of detoxifying, reducing swelling and easing pain, and the liquorice is used for harmonizing the drug properties of the various medicinal materials, so that the medicinal effects of the medicinal materials are better and synergistically exerted, and the toad extract has the effects of effectively preventing and treating the porcine reproductive and respiratory syndrome.
2. The functional additive is a microbial fermentation traditional Chinese medicine preparation, not only can dissolve out the active ingredients of the traditional Chinese medicine to the maximum extent, but also can protect the active ingredients of the traditional Chinese medicine to the maximum extent from being damaged, especially can effectively protect the active ingredients such as thermosensitive volatile oil, vitamins and the like, and during the fermentation process, the conversion of microorganisms and enzymes promotes the generation of active substances, so that the drug effect can be improved.
3. In the preparation of the functional additive, the fermented dregs of a decoction can be developed and reused as a drug property matrix, so that the problem of waste can be well solved, most of nutrient substances can be fully and effectively absorbed and utilized, the economic benefit of an enterprise can be improved, the drug source can be saved, and the resource protection is facilitated.
4. The functional additive of the invention is easy to digest and absorb after entering the organism, has quick effect, can quickly stimulate the organism to generate interferon, and prevent the absorption and invasion of viruses, thereby preventing the replication and infection of the viruses, and playing a good role in resisting viruses and improving the immunity of the organism.
5. The raw materials used in the invention are all green products without drug resistance, and the food safety is not affected.
Detailed Description
The technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a functional additive for blue-ear diseases, which comprises the following raw material components in parts by weight:
10 parts of acanthopanax, 10 parts of eucommia, 10 parts of astragalus, 8 parts of ginseng leaf, 8 parts of liquorice, 15 parts of isatis root, 15 parts of honeysuckle and 3 parts of toad extract.
This example provides a method for preparing the functional additive, comprising the steps of:
(1) cleaning and airing the traditional Chinese medicine raw materials, cutting the traditional Chinese medicine raw materials into 2cm sections, sterilizing the traditional Chinese medicine raw materials at the high temperature of 120-130 ℃ for 15 minutes, putting the traditional Chinese medicine raw materials into a fermentation tank, adding pure water in an amount which is 3-4 times of the weight of the traditional Chinese medicine raw materials, adding a strain accounting for 0.01-0.2% of the total fermentation material, and fermenting the mixture at the constant temperature of 37 ℃ for 3-5 days; wherein the added strain is any one or combination of yeast, bacillus subtilis and lactic acid bacteria.
(2) Pouring out the fermented traditional Chinese medicine liquid, filtering, adding the toad extract, uniformly stirring, moving to a traditional Chinese medicine extraction workshop, and concentrating the mixed liquid into paste;
(3) airing or drying the fermented traditional Chinese medicine residues, crushing and sieving the traditional Chinese medicine residues by a sieve of 60-120 meshes;
(4) and (3) uniformly mixing the paste obtained in the step (2) and the powder obtained in the step (3), drying, crushing again, sieving by a 60-120-mesh sieve, and subpackaging to obtain a finished product.
Example 2
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 15 parts of acanthopanax, 15 parts of eucommia, 15 parts of astragalus, 10 parts of ginseng leaf, 10 parts of liquorice, 10 parts of isatis root, 10 parts of honeysuckle and 4 parts of toad extract.
Example 3
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 10 parts of acanthopanax, 10 parts of eucommia, 15 parts of astragalus, 5 parts of ginseng leaf, 5 parts of liquorice, 10 parts of isatis root, 12 parts of honeysuckle and 5 parts of toad extract.
Example 4
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 15 parts of acanthopanax, 15 parts of eucommia, 10 parts of astragalus, 10 parts of ginseng leaf, 5 parts of liquorice, 12 parts of isatis root, 15 parts of honeysuckle and 4 parts of toad extract.
Example 5
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 12 parts of acanthopanax, 15 parts of eucommia, 10 parts of astragalus, 8 parts of ginseng leaf, 10 parts of liquorice, 10 parts of isatis root, 10 parts of honeysuckle and 3 parts of toad extract.
Example 6
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 10 parts of acanthopanax, 15 parts of eucommia, 10 parts of astragalus, 10 parts of ginseng leaf, 10 parts of liquorice, 15 parts of isatis root, 15 parts of honeysuckle and 5 parts of toad extract.
Example 7
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 15 parts of acanthopanax, 12 parts of eucommia, 12 parts of astragalus, 8 parts of ginseng leaf, 8 parts of liquorice, 10 parts of isatis root, 10 parts of honeysuckle and 5 parts of toad extract.
Example 8
The difference between the embodiment and the embodiment 1 is that the functional additive comprises the following raw material components in parts by weight: 12 parts of acanthopanax, 10 parts of eucommia, 15 parts of astragalus, 10 parts of ginseng leaf, 10 parts of liquorice, 15 parts of isatis root, 10 parts of honeysuckle and 3 parts of toad extract.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; these modifications and substitutions do not cause the essence of the corresponding technical solution to depart from the scope of the technical solution of the embodiments of the present invention, and are intended to be covered by the claims and the specification of the present invention.
Claims (7)
1. A functional additive for blue-ear disease is characterized by comprising the following raw materials in parts by weight:
10-15 parts of acanthopanax, 10-15 parts of eucommia, 10-15 parts of astragalus, 5-10 parts of ginseng leaf, 5-10 parts of liquorice, 10-15 parts of isatis root, 10-15 parts of honeysuckle and 3-5 parts of toad extract.
2. The functional additive for blue ear disease according to claim 1, characterized in that, the raw material components by weight portion comprise: 15 parts of acanthopanax, 15 parts of eucommia, 15 parts of astragalus, 10 parts of ginseng leaf, 10 parts of liquorice, 10 parts of isatis root, 10 parts of honeysuckle and 4 parts of toad extract.
3. The method for preparing the functional additive for blue ear disease according to claim 1 or 2, comprising the steps of:
(1) cleaning and drying the traditional Chinese medicine raw materials, cutting into sections, sterilizing at the high temperature of 120-130 ℃ for 15 minutes, putting into a fermentation tank, adding pure water and strains, and fermenting at the constant temperature of 37 ℃ for 3-5 days;
(2) pouring out the fermented Chinese medicinal liquid, filtering, adding Bufo siccus extract, stirring, and concentrating to obtain paste;
(3) drying and crushing the fermented traditional Chinese medicine residues;
(4) and (3) uniformly mixing the paste obtained in the step (2) and the powder obtained in the step (3), drying, crushing again, and packaging to obtain a finished product.
4. The preparation method of the functional additive for blue-ear disease according to claim 3, wherein the amount of the pure water added in the step (1) is 3-4 times of the weight of the traditional Chinese medicine raw materials.
5. The method for preparing a functional additive for blue ear disease according to claim 3, wherein the amount of added bacterial in step (1) is 0.01-0.2% of the total fermented material.
6. The method for preparing a functional additive for blue ear disease according to claim 3, wherein the bacterial species in step (1) is any one or any combination of yeast, Bacillus subtilis and lactic acid bacteria.
7. The preparation method of the functional additive for blue ear disease according to claim 3, wherein the step (3) and the step (4) are carried out by sieving with a 60-120 mesh sieve after being crushed.
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Cited By (1)
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| CN116726032A (en) * | 2023-06-09 | 2023-09-12 | 沈阳伟嘉生物技术有限公司 | Pharmaceutical composition for treating porcine reproductive and respiratory syndrome virus |
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2020
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|---|---|---|---|---|
| CN116726032A (en) * | 2023-06-09 | 2023-09-12 | 沈阳伟嘉生物技术有限公司 | Pharmaceutical composition for treating porcine reproductive and respiratory syndrome virus |
| CN116726032B (en) * | 2023-06-09 | 2023-11-17 | 沈阳伟嘉生物技术有限公司 | Pharmaceutical composition for treating porcine reproductive and respiratory syndrome virus |
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Application publication date: 20200825 |