CN107510771B - Traditional Chinese medicine composition for treating duck aeromonas hydrophila disease - Google Patents

Traditional Chinese medicine composition for treating duck aeromonas hydrophila disease Download PDF

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CN107510771B
CN107510771B CN201710755290.4A CN201710755290A CN107510771B CN 107510771 B CN107510771 B CN 107510771B CN 201710755290 A CN201710755290 A CN 201710755290A CN 107510771 B CN107510771 B CN 107510771B
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parts
herb
fruit
aeromonas hydrophila
duck
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CN107510771A (en
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蔡亚南
赵�权
张加力
温伟
孙永峰
隋玉建
陈绍辉
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Jilin Agricultural University
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Abstract

The invention discloses a traditional Chinese medicine composition for treating duck aeromonas hydrophila disease, which comprises the following components in parts by weight: 40-60 parts of discolor cinquefoil herb, 40-60 parts of paris polyphylla, 35-55 parts of rabdosia rubescens, 35-55 parts of shrubalthea flower, 30-50 parts of pomegranate bark, 30-50 parts of flaccid knotweed rhizome, 30-50 parts of Chinese gall, 30-50 parts of garden burnet root, 25-45 parts of eclipta alba, 25-45 parts of hairyvein agrimony, 25-45 parts of Chinese thorowax root, 20-40 parts of myrobalan, 20-40 parts of dark plum fruit, 20-40 parts of cherokee rose fruit, 20-40 parts of fructus aristolochiae, 20-40 parts of greater celandine herb, 15-35 parts of clove, 15-35 parts of chinaberry fruit and 15-35 parts. Clinical treatment tests prove that the cure rate of the prescription for treating the duck aeromonas hydrophila disease is 94.20%, and the effective rate is 97.81%.

Description

Traditional Chinese medicine composition for treating duck aeromonas hydrophila disease
The technical field is as follows:
the invention relates to a traditional Chinese medicine composition for treating poultry diseases, belongs to the field of animal medicine, and particularly relates to a traditional Chinese medicine composition specially used for treating duck aeromonas hydrophila disease.
Background
Aeromonas hydrophila is widely existed in fresh water, soil and sewage in nature, often causes infection and morbidity of aquatic animals such as fish, shrimp, waterfowl and the like, belongs to conditioned pathogenic bacteria, and is an acute septic infectious disease mainly infected through a digestive tract. The disease is very similar to duck virus hepatitis in the aspects of the age of the disease day, symptoms and pathological changes, but the disease has obvious duck lung lesion, pulmonary hemorrhage, edema and purple black color, bloody foam flows out of a section, and the disease can be primarily diagnosed by combining clinical dyspnea and more bacteria in lung contact sheets, and if the diagnosis is confirmed, laboratory examination is needed. The disease occurs all over the country, the morbidity rate is on the trend of rising year by year, the mortality rate is high, great loss is caused to farmers, and the disease becomes a new problem of the duck breeding industry.
1. Epidemiology
Aeromonas hydrophila is widely existed in water area environments such as lake water sources and sludge, and is a bacterium which is very easy to damage fishes and frogs. The duck-raising fishpond has rich water quality and rich nutrition, is convenient for the growth and the propagation of aeromonas hydrophila, and can cause infection when ducks move in water or eat fish and frogs with diseases and bacteria. Ducks of different ages in days are easy to get ill, the ill seasons are summer, and the mortality rate is high and is about 20% -60%.
2 clinical symptoms and pathological changes
The duck suffers from the symptoms of deficient spirit, anorexia or abominable appetite, stiff neck, difficulty in walking, drowsiness due to eye closure, dyspnea, mouth opening and breath accompanied by dyspnea and wheezing. Symptoms such as lying prone, paralysis and the like are serious, the patient is reluctant to drain, and some patients can drain but cannot move due to numbness of the legs; discharging grey white or light green thin manure frequently, wherein pasty thin manure is adhered to the anus feather of some ducks. In the later stage of the disease, the duck is prone, paralyzed in both legs, slow in movement or ataxia, and finally cannot rise over the ground, and the legs are in the shape of oars or in the shape of angle bows. Most ducks had hematomas on the shin and toe portions of their side and a red appearance. The case necropsy can show that a small amount of red ascites exists in the abdominal cavity; bleeding of internal organs, turgor of liver and dense arrangement of bleeding spots or bleeding spots; the lung is enlarged and diffuse bleeding is black and purple, and red foam-like liquid flows out of the section; coronary heart fat bleeding, cardiac serosa with bleeding spots of different sizes; spleen swelling, blood stasis, bleeding; intestinal mucosa exfoliation, diffuse bleeding; kidney stasis or bleeding; the tracheal mucosa bleeds annularly. The tibiotarsal and tibioplantar joints were swollen, with dark red blood flowing out of the toes and necrosis of the leg muscles.
3. Current prevention and treatment measures
Modern veterinary medicine mainly adopts various antibiotics for treating the disease, but the drug resistance causes unsatisfactory curative effect, high price, many toxic and side effects and the increase of drug residue in the duck body. Although emerging immunopotentiators, probiotics, vaccines and the like have certain effects on preventing and controlling the duck aeromonas hydrophila disease, the wide application of the immunopotentiators, probiotics, vaccines and the like is hindered by the use limitation, the irritation to organisms and the complexity of operation, and the immunopotentiators, the probiotics, the vaccines and the like are also one of important reasons for causing the difficulty in effectively preventing and controlling and radically treating the duck aeromonas hydrophila disease. The Chinese herbal medicines have the two-way regulating effect of immunity and antibiosis on the ducks, are easy to degrade, have no residue and no toxic or side effect, and are ideal medicines for treating the aeromonas hydrophila disease of the ducks. Therefore, the research and development of the traditional Chinese medicine composition for treating the duck aeromonas hydrophila disease is one of the new problems to be solved urgently by scientific research technicians in the field.
The invention content is as follows:
the invention aims to overcome the defects of the existing method for treating duck aeromonas hydrophila, and provides a decoction medicine for treating duck aeromonas hydrophila, which is easy to obtain materials, convenient to prepare, low in price and high in curative effect, and reduces medicine residues and toxic and side effects.
A traditional Chinese medicine composition for treating duck aeromonas hydrophila disease comprises the following components in parts by weight: 40-60 parts of discolor cinquefoil herb, 40-60 parts of paris polyphylla, 35-55 parts of rabdosia rubescens, 35-55 parts of shrubalthea flower, 30-50 parts of pomegranate bark, 30-50 parts of flaccid knotweed rhizome, 30-50 parts of Chinese gall, 30-50 parts of garden burnet root, 25-45 parts of eclipta alba, 25-45 parts of hairyvein agrimony, 25-45 parts of Chinese thorowax root, 20-40 parts of myrobalan, 20-40 parts of dark plum fruit, 20-40 parts of cherokee rose fruit, 20-40 parts of fructus aristolochiae, 20-40 parts of greater celandine herb, 15-35 parts of clove, 15-35 parts of chinaberry fruit and 15-35 parts.
The preferable weight components are as follows:
60 parts of discolor cinquefoil herb, 60 parts of rhizoma paridis, 55 parts of rabdosia rubescens, 55 parts of shrubalthea flower, 50 parts of pomegranate bark, 50 parts of flaccid knotweed, 50 parts of Chinese gall, 50 parts of garden burnet, 45 parts of eclipta alba, 45 parts of hairyvein agrimonia herb and bud, 45 parts of radix bupleuri, 40 parts of myrobalan, 40 parts of dark plum fruit, 40 parts of cherokee rose fruit, 40 parts of fructus aristolochiae, 40 parts of greater celandine herb, 35 parts of clove, 35 parts of chinaberry fruit and 35 parts of rhizoma alismatis.
Or the following steps:
40 parts of discolor cinquefoil herb, 40 parts of rhizoma paridis, 35 parts of rabdosia rubescens, 35 parts of shrubalthea flower, 30 parts of pomegranate rind, 30 parts of flaccid knotweed, 30 parts of Chinese gall, 30 parts of garden burnet, 25 parts of eclipta alba, 25 parts of hairyvein agrimonia herb and bud, 25 parts of radix bupleuri, 20 parts of myrobalan, 20 parts of dark plum fruit, 20 parts of cherokee rose fruit, 20 parts of fructus aristolochiae, 20 parts of greater celandine herb, 15 parts of clove, 15 parts of chinaberry fruit and 15 parts of rhizoma alis.
Or the following steps:
50 parts of discolor cinquefoil herb, 50 parts of rhizoma paridis, 45 parts of rabdosia rubescens, 45 parts of shrubalthea flower, 40 parts of pomegranate bark, 40 parts of flaccid knotweed, 40 parts of Chinese gall, 40 parts of garden burnet root, 35 parts of eclipta alba, 35 parts of hairyvein agrimonia herb and bud, 35 parts of radix bupleuri, 30 parts of myrobalan, 30 parts of dark plum fruit, 30 parts of cherokee rose fruit, 30 parts of fructus aristolochiae, 30 parts of greater celandine herb, 25 parts of clove, 25 parts of chinaberry fruit and 25 parts of rhizoma alis.
The invention mainly aims to provide a traditional Chinese medicine composition for treating duck aeromonas hydrophila disease, which is prepared by the following method:
1. weighing the components according to the raw material proportion of a traditional Chinese medicine composition for treating duck aeromonas hydrophila disease, mixing potentilla discolor, rhizoma paridis, pomegranate rind, gallnut, garden burnet root, radix bupleuri, myrobalan, dark plum, cherokee rose fruit, dutchmanspipe fruit and chinaberry fruit according to the weight proportion, putting the mixture into a pulverizer to be pulverized into fine powder, and sieving the fine powder with a 120-mesh sieve. The cold soaking method comprises placing pulverized medicinal materials into a soaking pot, adding 70% ethanol with the addition amount of 3 cm below the medicinal powder, covering, soaking for 5 days, and shaking or stirring frequently during soaking to accelerate leaching. Then taking out the maceration extract, filtering, squeezing the residue, and mixing the obtained squeezed solution with the leachate. Placing the residue in an impregnator, adding 70% ethanol, soaking for 5 days, squeezing the residue, and mixing the obtained squeezed solution with the leachate. Mixing the two soaking solutions, filtering, concentrating, and removing ethanol to obtain viscous liquid, i.e. No. 1 medicinal liquid.
2. Weighing the components according to the raw material proportion of the traditional Chinese medicine composition for treating duck aeromonas hydrophila, uniformly mixing rabdosia rubescens, hibiscus flower, flaccid knotweed, eclipta alba, hairyvein agrimony, celandine, clove and alisma orientale, and adding 6 times of water by weight to soak for 40 minutes. Decocting in a decocting pot for 30 min, filtering to remove residue, and collecting filtrate. Putting the dregs into a decocting pot again, decocting for 30 minutes, filtering again to remove the dregs, and taking the filtrate. Mixing the two filtrates to obtain No. 2 medicinal liquid.
Mixing the liquid medicines 1 and 2, and stirring well to obtain the Chinese medicinal composition for treating duck aeromonas hydrophila.
The formula principle of the invention is as follows:
according to the traditional veterinary medicine, the duck aeromonas hydrophila disease is caused by the fact that the duck aeromonas hydrophila disease is infected by epidemic toxin, and the duck aeromonas hydrophila disease is treated by clearing heat and removing toxicity, cooling blood and stopping bleeding, and astringing intestines to stop diarrhea. In the formula, potentilla discolor is sweet, bitter and cool in nature and enters liver, stomach and large intestine meridians. Sweet and bitter with the actions of relieving toxicity, cooling with the actions of removing heat, and bitter with the actions of drying dampness, it has the actions of clearing heat and removing toxicity, stopping bleeding and stopping dysentery. Especially has better curative effect on abdominal pain, diarrhea and persistent dysentery. Rhizoma paridis is bitter and slightly cold, enters liver meridian, and has the effects of clearing away heat and toxic materials, and relieving swelling and pain. Rabdosia rubescens, bitter, sweet and slightly cold, enters lung, kidney and liver meridians. Clearing away heat and toxic material, promoting blood circulation and relieving pain. The hibiscus syriacus flower is sweet and bitter in taste and cool. Enter spleen, lung and liver meridians. Has the functions of clearing heat, drying dampness, cooling blood and stopping dysentery. The four medicines are combined to have the obvious effects of clearing heat and removing toxicity, have better effect on treating the duck aeromonas hydrophila disease and are monarch medicines in the formula. Pomegranate rind is warm in nature and sour and astringent in taste. Enter the large intestine, lung and kidney meridians. Has the effects of relieving diarrhea with astringents, stopping bleeding, and expelling parasites. It is indicated for chronic diarrhea, dysentery, hematochezia and rectal prolapse. Polygonum hydropiper is pungent, pungent and warm in nature, and enters stomach and large intestine meridians. Has effects in clearing away toxic materials, eliminating dampness, dispelling blood stasis, and stopping bleeding. Has good curative effect on dysentery, gastroenteritis, diarrhea and other diseases. Galla chinensis is cold in nature and sour in taste, and has the effects of astringing lung to reduce pathogenic fire, astringing intestine to stop diarrhea, stopping bleeding and astringing dampness. Sanguisorba officinalis is slightly cold in bitter acid and enters liver, stomach and large intestine channels, and has the effects of cooling blood, stopping bleeding, astringing and detoxifying. The eclipta alba is cool in nature; sweet sour; it enters liver and kidney meridians. It is indicated for bleeding due to yin deficiency and blood heat because it can tonify yin of liver and kidney, cool blood and stop bleeding. Has good effects of cooling blood, stopping bleeding, tonifying kidney and benefiting yin, and has better treatment effect on various hemorrhagic diseases. The agrimony is mild in nature and taste, bitter and astringent in flavor, and enters the stomach, liver, spleen, lung and large intestine meridians. Has the functions of astringing to stop bleeding, stopping dysentery and detoxifying. The six medicines are combined to have the obvious functions of cooling blood and stopping bleeding, dissipating blood stasis and removing toxicity, and relieving diarrhea with astringents, and are used as ministerial medicines in the prescription. In addition, the combination of Hairyvein agrimony and hibiscus flower has the obvious effects of clearing away heat and toxic material and stopping dysentery and filthy. The agrimony is bitter and astringent, and astringes to stop bleeding; the hibiscus syriacus flower is sweet and cool, has the functions of clearing heat and removing toxicity, activating blood and expelling pus, and cooling blood and stopping dysentery, has the functions of clearing heat, cooling blood, stopping bleeding and stopping dysentery by combining the two medicines, brings out the best in each other, has the functions of clearing heat, cooling blood, stopping bleeding and stopping dysentery, can enhance the functions of removing toxicity and removing dirt, and has better effect of treating the hydropsy monascus disease of the duckling. Chai Hu is bitter and slightly cold. Enter liver, gallbladder, pericardium and triple energizer meridians. Has the effects of relieving fever, soothing liver, regulating qi and lifting yang qi. It is the essential herb for harmonizing Shaoyang meridian, has good action of soothing liver and qi stagnation, and is an essential herb for relieving liver qi stagnation. Moreover, it is good at lifting qi of clear yang, so it is indicated for chronic diarrhea and rectocele due to qi deficiency sinking. Myrobalan, bitter, sour, astringent and warm in nature, enters lung and large intestine channels, and has the effects of astringing, astringing intestine, descending qi and stopping diarrhea. Dark plum is sour, astringent and neutral, and enters liver, spleen, lung and large intestine meridians. Astringe lung to stop cough, astringe intestine to check diarrhea, promote fluid production to quench thirst. It is indicated for chronic cough, chronic dysentery and diarrhea due to lung deficiency. Cherokee rose fruit is sour, sweet and astringent in taste and mild in nature. It enters kidney, bladder and large intestine meridians. Has the effects of securing essence and reducing urination, securing metrorrhagia and leukorrhagia, and relieving diarrhea with astringents. The combination of the four herbs has the obvious effect of astringing intestine to check diarrhea. Ma Dou Ling is bitter, slightly pungent and cold. Enter lung and large intestine meridians. Clear lung heat and resolve phlegm, relieve cough and dyspnea, clear intestine and eliminate hemorrhoid. It is commonly indicated for cough due to lung heat, profuse phlegm, dyspnea and tachypnea, and also has the actions of clearing heat and calming liver, so it is indicated for hypertension due to hyperactivity of liver yang. The aristolochia debilis is matched with the garden burnet root in the prescription, and has good effects of clearing intestines and stopping bleeding. Chelidonium majus is cool in nature and bitter in taste. It enters lung, heart and kidney meridians. Has analgesic, antitussive, diuretic, and toxic materials clearing away effects. It is used to treat stomachache, abdominal pain, enteritis, dysentery, and cough. The fructus Aristolochiae and herba Chelidonii are combined to have good effects of clearing lung-heat, lowering qi, relieving cough and asthma, clearing intestine and promoting urination. Clove is pungent and warm. Enter lung, stomach, spleen and kidney meridians. It has the actions of warming middle energizer to check adverse rise of qi, warming kidney and tonifying yang, so it is the essential herb for vomiting due to stomach cold, and warming kidney to strengthen yang. It is indicated for diarrhea. Ku Lian Zi is bitter in taste and cold in nature. It enters liver and stomach meridians. Has the functions of promoting qi circulation, relieving pain and killing parasites. Can be used for treating abdominal pain, hypochondriac pain, hernia pain, and abdominal pain due to parasitic infestation. Ze Xie is sweet, bland and cold. Enter kidney and bladder meridians. Has the effects of promoting diuresis, eliminating dampness and purging kidney fire. It is indicated for dysuria, edema, fullness and distention, stranguria with turbid urine, and diarrhea due to retention of water and dampness. The nine medicines are used as adjuvant and guiding medicines in the prescription. The combination of the whole formula of the medicine can achieve the effects of clearing heat and removing toxicity, relieving diarrhea with astringents, cooling blood and stopping bleeding. Has good curative effect on the duck aeromonas hydrophila disease.
The preparation method is characterized in that: the recipe has the combined effects of clearing away heat and toxic material, astringing intestine to stop diarrhea, cooling blood to stop bleeding, regulating qi movement, astringing lung to stop cough, nourishing liver and kidney, inducing diuresis and excreting dampness.
The medicines are organically combined, dialectically matched and mutually assisted, and the effects of clearing away heat and toxic materials, relieving diarrhea with astringents and cooling blood and stopping bleeding of the formula are enhanced, so that the aim of curing the duck aeromonas hydrophila disease is fulfilled. Clinical treatment tests prove that the cure rate of the prescription for treating the duck aeromonas hydrophila disease is 94.20%, and the effective rate is 97.81%.
Detailed Description
Example 1
The weight components are as follows: 60 parts of discolor cinquefoil herb, 60 parts of rhizoma paridis, 55 parts of rabdosia rubescens, 55 parts of shrubalthea flower, 50 parts of pomegranate bark, 50 parts of flaccid knotweed, 50 parts of Chinese gall, 50 parts of garden burnet, 45 parts of eclipta alba, 45 parts of hairyvein agrimonia herb and bud, 45 parts of radix bupleuri, 40 parts of myrobalan, 40 parts of dark plum fruit, 40 parts of cherokee rose fruit, 40 parts of fructus aristolochiae, 40 parts of greater celandine herb, 35 parts of clove, 35 parts of chinaberry fruit and 35 parts of rhizoma alismatis.
Example 2
The weight components are as follows: 40 parts of discolor cinquefoil herb, 40 parts of rhizoma paridis, 35 parts of rabdosia rubescens, 35 parts of shrubalthea flower, 30 parts of pomegranate rind, 30 parts of flaccid knotweed, 30 parts of Chinese gall, 30 parts of garden burnet, 25 parts of eclipta alba, 25 parts of hairyvein agrimonia herb and bud, 25 parts of radix bupleuri, 20 parts of myrobalan, 20 parts of dark plum fruit, 20 parts of cherokee rose fruit, 20 parts of fructus aristolochiae, 20 parts of greater celandine herb, 15 parts of clove, 15 parts of chinaberry fruit and 15 parts of rhizoma alis.
Example 3
The weight components are as follows: 50 parts of discolor cinquefoil herb, 50 parts of rhizoma paridis, 45 parts of rabdosia rubescens, 45 parts of shrubalthea flower, 40 parts of pomegranate bark, 40 parts of flaccid knotweed, 40 parts of Chinese gall, 40 parts of garden burnet root, 35 parts of eclipta alba, 35 parts of hairyvein agrimonia herb and bud, 35 parts of radix bupleuri, 30 parts of myrobalan, 30 parts of dark plum fruit, 30 parts of cherokee rose fruit, 30 parts of fructus aristolochiae, 30 parts of greater celandine herb, 25 parts of clove, 25 parts of chinaberry fruit and 25 parts of rhizoma alis.
Example 4
A pharmaceutical composition for treating equine azonuria is prepared by the following steps:
1. weighing the components according to the raw material proportion of a traditional Chinese medicine composition for treating duck aeromonas hydrophila disease, mixing potentilla discolor, rhizoma paridis, pomegranate rind, gallnut, garden burnet root, radix bupleuri, myrobalan, dark plum, cherokee rose fruit, dutchmanspipe fruit and chinaberry fruit according to the weight proportion, putting the mixture into a pulverizer to be pulverized into fine powder, and sieving the fine powder with a 120-mesh sieve. The cold soaking method comprises placing pulverized medicinal materials into a soaking pot, adding 70% ethanol with the addition amount of 3 cm below the medicinal powder, covering, soaking for 5 days, and shaking or stirring frequently during soaking to accelerate leaching. Then taking out the maceration extract, filtering, squeezing the residue, and mixing the obtained squeezed solution with the leachate. Placing the residue in an impregnator, adding 70% ethanol, soaking for 5 days, squeezing the residue, and mixing the obtained squeezed solution with the leachate. Mixing the two soaking solutions, filtering, concentrating, and removing ethanol to obtain viscous liquid, i.e. No. 1 medicinal liquid.
2. Weighing the components according to the raw material proportion of the traditional Chinese medicine composition for treating duck aeromonas hydrophila, uniformly mixing rabdosia rubescens, hibiscus flower, flaccid knotweed, eclipta alba, hairyvein agrimony, celandine, clove and alisma orientale, and adding 6 times of water by weight to soak for 40 minutes. Decocting in a decocting pot for 30 min, filtering to remove residue, and collecting filtrate. Putting the dregs into a decocting pot again, decocting for 30 minutes, filtering again to remove the dregs, and taking the filtrate. Mixing the two filtrates to obtain No. 2 medicinal liquid.
Mixing the liquid medicines 1 and 2, and stirring well to obtain the Chinese medicinal composition for treating duck aeromonas hydrophila.
Wherein, the traditional Chinese medicine composition for treating duck aeromonas hydrophila prepared in the embodiment 1 and the embodiment 4 contains 1.2 g of crude drugs per milliliter;
the traditional Chinese medicine composition for treating duck aeromonas hydrophila prepared in the embodiment 2 and the embodiment 4 contains 1.0 g of crude drugs per milliliter;
the traditional Chinese medicine composition for treating duck aeromonas hydrophila prepared in the embodiment 3 and the embodiment 4 contains 1.1 g of crude drugs per milliliter;
examples of the experiments
1. The method comprises selecting six families of farms and individual duck farmers who have the duck aeromonas hydrophila disease, wherein the total number of the diseased goslings is 4673, and the age is 10-28 days. The diseased ducklings are divided into three groups, namely a group of the invention, a group of three-yellow plus white powder and a control group.
The invention group: the concentrated solutions prepared in example 3 and example 4 were administered in 4ml portions to each gosling. For sick goslings capable of drinking water, 30% of brown sugar can be added into the liquid medicine for convenient drinking, and for the goslings with serious illness, 15 drops of the liquid medicine can be dripped into each gosling for twice a day. Controlling the medicine temperature: it is administered at 40-50 deg.C.
The three-yellow plus white powder group: cortex Phellodendri, Scutellariae radix, radix Pulsatillae 500 g each, Coptidis rhizoma, Polyporus, Alismatis rhizoma 300 g each, fructus Aurantii, cortex Magnolia officinalis, fructus Amomi, and rhizoma Atractylodis 200g each. The use method comprises the following steps: decocting with water twice, mixing the decoctions, adding 30% brown sugar, and administering to duck for 5 days. Controlling the medicine temperature: it is administered at 40-50 deg.C. The dosage is the daily dosage of 1000 ducklings.
Control group: only adding a proper amount of white sugar into drinking water. Controlling water temperature: it is administered at 40-50 deg.C.
The treatment time is five days, and the medicine is taken or drunk once in the morning and afternoon every day;
Figure DEST_PATH_IMAGE002
2. and (3) judging the curative effect:
the disease is cured, the symptoms of the duck aeromonas hydrophila disease completely disappear, the appetite and drinking water are recovered to be normal, and no abnormality is found in pathological section examination.
The improvement is that the symptoms of the duck aeromonas hydrophila disease are improved, the appetite and drinking water are recovered, and the pathological anatomy is improved before the pathological anatomy examination.
The symptoms of duck aeromonas hydrophila disease are not changed, and the appetite, drinking water and pathological anatomy are the same as before treatment.
3. As a result: 4673 ducklings are treated by different administration schemes for five days, and the treatment effect of each group is shown in table 2;
Figure DEST_PATH_IMAGE004
as can be seen from Table 2, the treatment and control groups have different treatment effects on the duck aeromonas hydrophila, wherein the treatment effect of the group is the best, the cure rate reaches 94.20%, the total effective rate is 97.81%, the total effective rate is remarkably higher than that of the other two groups (P <0.01), the three-yellow plus-white group is second, the control group has no treatment effect, and the statistical result shows that the difference between the groups is remarkable (P < 0.01). The 40 ducklings which are ineffective in the group are all cases which die in 1-4 days at the initial treatment stage, and die because the disease condition is serious, the internal organs of the body are exhausted, and the drug effect is not fully exerted.
Practice proves that the medicine can clear away heat and toxic materials, relieve diarrhea with astringents, cool blood and stop bleeding, regulate qi activity, astringe lung and relieve cough, nourish liver and kidney, promote diuresis and eliminate dampness, can effectively treat the duck aeromonas hydrophila disease, has obvious effects of sterilizing and detoxifying and improving the immune function of organisms, and has obvious curative effect. Has better treatment effect on the duck aeromonas hydrophila disease. The Chinese medicinal composition has the advantages of wide medicament source, low cost, high cure rate, no medicament residue, no toxic or side effect and easy absorption by ducklings, and provides a feasible new medicament for clinically treating the disease.
The above detailed descriptions of the Chinese medicinal composition for treating duck aeromonas hydrophila and the preparation method thereof with reference to the embodiments are illustrative and not restrictive, and several embodiments can be enumerated according to the limited scope, so that changes and modifications without departing from the general concept of the present invention shall fall within the protection scope of the present invention.

Claims (5)

1. A traditional Chinese medicine composition for treating duck aeromonas hydrophila disease comprises the following components in parts by weight: 40-60 parts of discolor cinquefoil herb, 40-60 parts of paris polyphylla, 35-55 parts of rabdosia rubescens, 35-55 parts of shrubalthea flower, 30-50 parts of pomegranate bark, 30-50 parts of flaccid knotweed rhizome, 30-50 parts of Chinese gall, 30-50 parts of garden burnet root, 25-45 parts of eclipta alba, 25-45 parts of hairyvein agrimony, 25-45 parts of Chinese thorowax root, 20-40 parts of myrobalan, 20-40 parts of dark plum fruit, 20-40 parts of cherokee rose fruit, 20-40 parts of fructus aristolochiae, 20-40 parts of greater celandine herb, 15-35 parts of clove, 15-35 parts of chinaberry fruit and 15-35 parts.
2. The traditional Chinese medicine composition for treating duck aeromonas hydrophila disease according to claim 1, which is characterized by comprising the following components in parts by weight: 60 parts of discolor cinquefoil herb, 60 parts of rhizoma paridis, 55 parts of rabdosia rubescens, 55 parts of shrubalthea flower, 50 parts of pomegranate bark, 50 parts of flaccid knotweed, 50 parts of Chinese gall, 50 parts of garden burnet, 45 parts of eclipta alba, 45 parts of hairyvein agrimonia herb and bud, 45 parts of radix bupleuri, 40 parts of myrobalan, 40 parts of dark plum fruit, 40 parts of cherokee rose fruit, 40 parts of fructus aristolochiae, 40 parts of greater celandine herb, 35 parts of clove, 35 parts of chinaberry fruit and 35 parts of rhizoma alismatis.
3. The traditional Chinese medicine composition for treating duck aeromonas hydrophila disease according to claim 1, which is characterized by comprising the following components in parts by weight: 40 parts of discolor cinquefoil herb, 40 parts of rhizoma paridis, 35 parts of rabdosia rubescens, 35 parts of shrubalthea flower, 30 parts of pomegranate rind, 30 parts of flaccid knotweed, 30 parts of Chinese gall, 30 parts of garden burnet, 25 parts of eclipta alba, 25 parts of hairyvein agrimonia herb and bud, 25 parts of radix bupleuri, 20 parts of myrobalan, 20 parts of dark plum fruit, 20 parts of cherokee rose fruit, 20 parts of fructus aristolochiae, 20 parts of greater celandine herb, 15 parts of clove, 15 parts of chinaberry fruit and 15 parts of rhizoma alis.
4. The traditional Chinese medicine composition for treating duck aeromonas hydrophila disease according to claim 1, which is characterized by comprising the following components in parts by weight: 50 parts of discolor cinquefoil herb, 50 parts of rhizoma paridis, 45 parts of rabdosia rubescens, 45 parts of shrubalthea flower, 40 parts of pomegranate bark, 40 parts of flaccid knotweed, 40 parts of Chinese gall, 40 parts of garden burnet root, 35 parts of eclipta alba, 35 parts of hairyvein agrimonia herb and bud, 35 parts of radix bupleuri, 30 parts of myrobalan, 30 parts of dark plum fruit, 30 parts of cherokee rose fruit, 30 parts of fructus aristolochiae, 30 parts of greater celandine herb, 25 parts of clove, 25 parts of chinaberry fruit and 25 parts of rhizoma alis.
5. A traditional Chinese medicine composition for treating duck aeromonas hydrophila disease is prepared by the following method:
1) weighing the components according to the raw material proportion of the traditional Chinese medicine composition for treating duck aeromonas hydrophila disease of claim 1, mixing potentilla discolor, rhizoma paridis, pomegranate rind, gallnut, garden burnet root, radix bupleuri, myrobalan, dark plum fruit, cherokee rose fruit, fructus aristolochiae and chinaberry fruit according to the weight proportion, putting the mixture into a pulverizer to be pulverized into fine powder, and sieving the fine powder with a 120-mesh sieve;
placing the pulverized medicine into a dipping pot by adopting a cold dipping method, adding 70% alcohol, covering with a cover, dipping for 5 days, and shaking or stirring frequently in the dipping process to accelerate the leaching;
then taking out the maceration extract, filtering, squeezing the residue, and mixing the obtained squeezed solution with the lixivium;
putting the residue into a macerator, adding 70% ethanol, soaking for 5 days, squeezing the residue, and mixing the obtained squeezed solution with the leachate;
mixing the two soaking solutions, filtering, concentrating, and removing ethanol to obtain viscous liquid, i.e. No. 1 medicinal liquid;
2) weighing the components according to the raw material proportion of the traditional Chinese medicine composition for treating duck aeromonas hydrophila disease of claim 1, uniformly mixing rabdosia rubescens, hibiscus syriacus, flaccid knotweed herb, eclipta alba, hairyvein agrimony, greater celandine herb, clove and alisma orientale, and adding 6 times of water by weight to soak for 40 minutes;
putting into a decocting pot, decocting for 30 minutes, filtering to remove residues, and collecting filtrate;
putting the dregs into a decocting pot again, decocting for 30 minutes, filtering again to remove the dregs, and taking the filtrate;
mixing the two filtrates to obtain No. 2 medicinal liquid;
mixing the liquid medicines 1 and 2, and stirring to obtain the Chinese medicinal composition for treating duck aeromonas hydrophila.
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Citations (2)

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CN102920990A (en) * 2012-11-27 2013-02-13 遵义师范学院 Chinese herbal medicinal prescription for preventing and treating aeromonas hydrophila fish disease
CN106310200A (en) * 2016-10-17 2017-01-11 安庆市柯旷动物药业有限公司 Traditional Chinese medicinal composition for preventing and treating diarrhea of livestock and poultry

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102920990A (en) * 2012-11-27 2013-02-13 遵义师范学院 Chinese herbal medicinal prescription for preventing and treating aeromonas hydrophila fish disease
CN106310200A (en) * 2016-10-17 2017-01-11 安庆市柯旷动物药业有限公司 Traditional Chinese medicinal composition for preventing and treating diarrhea of livestock and poultry

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