CN105596848A

CN105596848A - Preparation mainly for treating external hemorrhoids and preparing method thereof

Info

Publication number: CN105596848A
Application number: CN201610062542.0A
Authority: CN
Inventors: 不公告发明人
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-29
Filing date: 2016-01-29
Publication date: 2016-05-25

Abstract

The invention discloses a preparation mainly for treating external hemorrhoids. The preparation is prepared from, by weight, 6-10 parts of rhizoma alismatis, 10-13 parts of stem or leaf of fortune euonymus, 6-8 parts of herb of common ammannia, 4-7 parts of centipedaplant herb, 5-9 parts of siberian elm bark, 10-12 parts of mountain oreas herb, 3.5-6.5 parts of fructus cnidii, 4-7 parts of zostera marina, 2-5 parts of flower of Japanese glorybower, 3.5-6.5 parts of leaf of omei mountain bamboo, 7-11 parts of lysimachia cletheroides, 5-9 parts of radix sophorae flavescentis, 3-6 parts of herb of dewberryleaf cinquefoil, 2.5-5.5 parts of long stephania herb and 4-6 parts of shorthairy antenoron. The preparation has the advantages that the medicinal materials are scientifically compatible and supplement one another to achieve sterilization and inflammation diminishing, astringency and hemostasis, and swelling and pain relief, the curative effect is stable, using is safe, and no toxic or side effect is caused; the medicinal materials are easy to obtain and low in cost, so that the burden of patients is relieved.

Description

A kind of preparation and method for making that cures mainly external piles

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and method for making that cures mainly external piles.

Background technology

Hemorrhoid are a kind of common anal and intestinal diseases, have saying of " ten people's nine hemorrhoid ". When morbidity misery unbearably, to people's life of workingLive and brought very large impact. What hemorrhoid were common is divided into internal piles, external piles and mixed hemorrhoid, and external piles is positioned at below tooth trace, is by outside hemorrhoidVeniplex varicose or anus edge pleat chafing, hypertrophy, connective tissue proliferation or the thrombus stasis of blood stagnant and form lump. External piles surfaceLid, with skin, can be seen, can not send in anus, be difficult for hemorrhage, taking pain and have foreign body sensation as cardinal symptom. Clinically often be divided intoConnective tissue external piles, varication external piles, inflammatory external hemorrhoid and thrombosed external hemorrhoid, wherein the most common with inflammatory external hemorrhoid, main manifestationsFor anus edge skin fold projection, red and swollen heat pain, oedema, obviously congested, have tenderness, and when defecation, pain increases the weight of, and has a small amount of secretionThing, what have can be with general malaise and heating.

The main cause that external piles forms has: (1) abdominal pressure increases. Women, at the gestational period or male prostate hypertrophy etc., canCause the formation of external piles. (2) physiologic factor. Because it is poor that local blood refluxes, thus enlargement of pipe extravasated blood easily caused, now with regard to shapeBecome external piles. (3) eating habit. Eat for a long time pungent stimulation, the food of delicious food savoury, is very easy to cause the generation of external piles.(4) bowl evacuation habit. The overlong time of defecation, when defecation, too with sudden force, the number of times of defecation too much all can form external piles. (5) badPosition. The people who be engaged in station of a specified duration, sitting, squat for a long time, goes for a long time easily causes external piles. (6) excessive fatigue. Working time is long, too laborTired, well do not had a rest, now the generation of external piles is inevitable. (7) other diseases. Some disease can cause external pilesForm, such as hypertension, cirrhosis, artery sclerosis, anal orifice and rectal intestine chronic inflammation etc.

Application publication number CN104873725A(application number 201510281567.5) Chinese invention patent document openA kind of Chinese medicine plastics for the treatment of inflammatory external hemorrhoid sore, made by the raw material of following parts by weight: adder-wort 55-60 part, flea stop 22-24 parts, Radix Rhapontici seu Radix Echinopsis 30-38 part, radix ampelopsis 29-32 part, madder 15-17 part, trilliaceae 22-24 part, scouring rush 8-11 part, Salvia chinensis 12-14 parts, sealwort 23-26 part, wolf's milk 18-21 part, Common Sage Herb 30-35 part, teasel root chrysanthemum 37-40 part, crow green onion 42-46 part, large fourthGrass 22-27 part, hieracioides 15-20 part, yellow quail dish 33-38 part, Herba Vernoniae Cinereae 45-49 part, Pu root 40-42 part, Mao Xu Cao 28-35Part, spun gold refer to cucurbit 52-56 part. Application publication number CN103860860A(application number 201410052881.1) middle promulgated by the State CouncilBright patent documentation discloses a kind of Chinese medicinal liniment for the treatment of external piles, is made up of the raw material of following weight portion: tarragon 20-25, mulberry are postedRaw 10-12, saltcake 3-5, Japanses beauty-berry grass 2-4, motherwort 3-5, red psychotria root 1-3, lichen 2-4, Fructus Sophorae 4-5, dried persimmon 10-15, ZhuSand lotus 6-8, courage 2-4, lily 3-5, climbing groundsel 3-4, purslane 10-15, sessile alternanthera herb 2-4 and Herba Kalimeridis 3-5. Application is publicCloth CN104013838A(application number 201410191141.6) Chinese invention patent document disclose outside one treatsThe external application Chinese medicine of hemorrhoid, is made up of the raw material of following weight portion:: parasitic loranthus 5-7, root of Dahurain angelica 3-5, Asian puccoon 5-7, kuh-seng 2-4, cacumen biotae6-8, dragon's blood 2-4, bermudagrass herb 1-3, radix bupleuri 3-5, garden burnet leaf 6-8, rattletop 4-5, honey-fried licorice root 3-5, dandelion 2-4, pachyrhizus leaf 5-7, purslane 5-10, chrysanthemum 10-15, leaf of white turnip 10-15, Fructus Aurantii 3-5, Chinese violet 2-4, chingma abutilon seed 1-3, Agrimony 3-5,Spend the female dish 3-5 of pig, ceylon leucas herb 2-4 and fine stern wind 1-2 in vain.

The method for the treatment of external piles is a lot of at present, mainly adopts operative treatment and medicine treatment. Operative treatment has painful large,The shortcomings such as safety coefficient is low, and expense is high, and wound healing time is long, Most patients is reluctant to accept. And existing medicine comprises mouthTake medicine, although easy operatings such as externally used pastes, result for the treatment of is not obvious, can only mitigation symptoms, and cure rate is lower.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide that a kind of result for the treatment of is fast, cure rate is high, safety is without secondaryThe preparation that cures mainly external piles and the preparation method of effect.

Technical scheme of the present invention is:

A preparation that cures mainly external piles, is prepared from by following bulk drugs, is weight portion: rhizoma alismatis 6-10; Winter creeper 10-13;Water three-coloured amaranth 6-8; Centipedaplant herb 4-7; Siberian elm brak 5-9; Oreas martiana(Hopp. Et Hornsch．) Brid 10-12; Frutus cnidii 3.5-6.5; Zostera marina 4-7; Flos clerodendri japonici 2-5;Omei mountain bamboo juvenile leaf 3.5-6.5; Loosestrife 7-11; Kuh-seng 5-9; The sub-bamboo mat spread on the floor for people to sit in ancient China 3-6 of pheasant; Long Stephania Herb 2.5-5.5; Shorthairy Antenoron 4-6.

Preferably scheme is, rhizoma alismatis 7-9; Winter creeper 11-12; Water three-coloured amaranth 6.5-7.5; Centipedaplant herb 5-6; Siberian elm brak 6-8; OxHair seven 10.5-11.5; Frutus cnidii 4.5-5.5; Zostera marina 5-6; Flos clerodendri japonici 3-4; Omei mountain bamboo juvenile leaf 4.5-5.5; Loosestrife 8-10; Kuh-seng6-8; The sub-bamboo mat spread on the floor for people to sit in ancient China 4-5 of pheasant; Long Stephania Herb 3.5-4.5; Shorthairy Antenoron 4.5-5.5.

Be more preferably rhizoma alismatis 8; Winter creeper 11.5; Water three-coloured amaranth 7; Centipedaplant herb 5.5; Siberian elm brak 7; Oreas martiana(Hopp. Et Hornsch．) Brid 11; Frutus cnidii5; Zostera marina 5.5; Flos clerodendri japonici 3.5; Omei mountain bamboo juvenile leaf 5; Loosestrife 9; Kuh-seng 7; The sub-bamboo mat spread on the floor for people to sit in ancient China 4.5 of pheasant; Long Stephania Herb 4; Shorthairy Antenoron 5.

A preparation method who cures mainly the ointment of the preparation of external piles, step is as follows:

(1) Siberian elm brak, winter creeper and kuh-seng fully be dry, pulverize into fine powder, cross 30-60 mesh sieve (preferred mistake 45 mesh sieves),Mixing fine powders, immerses gained mixing fine powders in sesame oil, soaks 2-4 days (preferably under normal temperature, soaking 3 days), through centrifuge under normal temperatureAfter centrifugal, get supernatant liquor for subsequent use;

(2) to the butter that adds in frutus cnidii 0.15-0.35 doubly to measure (preferably to the butter that adds 0.25 times of amount in frutus cnidii), mixEven, little fire is fried to butter exhaustion, has fragrance to overflow, and takes out, for subsequent use;

(3) by rhizoma alismatis, water three-coloured amaranth, centipedaplant herb, Oreas martiana(Hopp. Et Hornsch．) Brid, Zostera marina, Flos clerodendri japonici, omei mountain bamboo juvenile leaf, loosestrife, the sub-bamboo mat spread on the floor for people to sit in ancient China of pheasant, Long Stephania HerbFully dry with Shorthairy Antenoron, together smash into meal to pieces with step (2) frutus cnidii after treatment, for subsequent use;

(4) by step (3) gained meal, be placed in percolator, the ethanol taking concentration as 50%-70% is as solvent is (preferably with concentrationBe that 60% ethanol is solvent), carry out diacolation according to percolation, collect percolate, to filter, filtrate is after reclaiming ethanol, with step(1) gained supernatant mixes, and is evaporated to the thick paste that 80 DEG C of relative densities are 1.32-1.35, for subsequent use;

(5) in step (4) gained thick paste, add ointment bases, mix, sterilizing encapsulation, to obtain final product.

The preparation method of the ointment of above-mentioned a kind of preparation that cures mainly external piles, preferred scheme is, soft described in step (5)Cream base matter is the lanolin of 0.6 times of thick paste amount and the vaseline of 1.1 times of thick paste amounts.

The preparation method of described tablet is:

(1) to the butter that adds in frutus cnidii 0.15-0.35 doubly to measure (preferably to the butter that adds 0.25 times of amount in frutus cnidii), mixEven, little fire is fried to butter exhaustion, has fragrance to overflow, and takes out, and grinds as fine powder, for subsequent use;

(2) kuh-seng, Siberian elm brak, Long Stephania Herb and loosestrife are mixed, be placed in frying pan, add the clear water that 7-10 doubly measures and (preferably add 8.5The doubly clear water of amount), slow fire boiling 50-70 minute (preferably slow fire boiling 60 minutes), filters, and filtrate decompression is condensed into thick paste, sprayMist is dry, and the powder that gets dry extract is for subsequent use;

(3) after surplus stock medicine is fully dry, be placed in pulverizer and be ground into fine powder, with step (1) gained fine powder and step(2) gained dried cream powder mixes, and crosses 50-80 mesh sieve (preferred mistake 65 mesh sieves), adds auxiliary material, stirs, and is pressed into tablet, to obtain final product.

The preparation method of the tablet of above-mentioned a kind of preparation that cures mainly external piles, preferably scheme is, auxiliary material described in step (3)For the mass fraction talcum powder that is 3.3% and the mass fraction stearic acid that is 1.7%.

The preparation method of described capsule is:

(1) rhizoma alismatis, Zostera marina, kuh-seng, the sub-bamboo mat spread on the floor for people to sit in ancient China of pheasant, Oreas martiana(Hopp. Et Hornsch．) Brid and winter creeper are mixed, be ground into fine powder through plant pulverizer, mistake45-75 mesh sieve (preferred mistake 60 mesh sieves), the ethanolic solution that the concentration that is placed in 50 DEG C is 55% soaks and (preferably soaks for 1-4 hour2.5 hours), the ultrasonic extraction tank that is then 420W through power extracts the 35-55 minute (ultrasonic wave that is preferably 420W through powerExtractor extracts 45 minutes), extract, after centrifugal, is collected supernatant liquor;

(2) step (2) gained supernatant liquor is removed to residual ethanol, what to be evaporated to 70 DEG C of relative densities be 1.22-1.25Clear cream, for subsequent use;

(3) to the butter that adds in frutus cnidii 0.15-0.35 doubly to measure (preferably to the butter that adds 0.25 times of amount in frutus cnidii), mixEven, little fire is fried to butter exhaustion, has fragrance to overflow, and takes out, and grinds as fine powder, for subsequent use; Flos clerodendri japonici is placed in medicine cookeding pot, and little fire stir-fries6-10 minute (preferred little fire stir-fries 8 minutes), spray yellow rice wine, continues to fry to yellow rice wine and is sucked, and takes out, and grinds as fine powder, for subsequent use;

(4) surplus stock medicine fully be dry, pulverize into fine powder, mix with step (3) gained fine powder, cross 75-95 mesh sieve (preferablyCross 85 mesh sieves), join in the clear cream of step (2) gained, mix, granulate, dry, whole grain, incapsulates shell, to obtain final product.

The preparation method of the capsule of above-mentioned a kind of preparation that cures mainly external piles, is characterized in that, the amount of yellow rice wine in step (3)For the 0.28-0.4 of described raw material dose doubly (amount of preferred yellow rice wine be described raw material dose 0.32-0.36 doubly, be more preferablyThe amount of yellow rice wine be 0.34 times of described raw material dose).

The preparation method of described lotion is:

(1) kuh-seng, rhizoma alismatis and Siberian elm brak mix, and are placed in Chinese medicament extracting device, the ethanol taking concentration as 50%-80% as solvent (excellentThe ethanol of choosing taking concentration as 65% is as solvent), heating and refluxing extraction twice, each each extraction (preferably respectively carried for 30-40 minute at every turnGet 35 minutes), merge extracted twice liquid, filter, filtrate recycling ethanol, for subsequent use;

(2) Flos clerodendri japonici is placed in medicine cookeding pot, and little fire stir-fries 6-10 minute (preferred little fire stir-fries 8 minutes), spray 0.34 times described inThe yellow rice wine of raw material dose, continues to fry to yellow rice wine and is sucked, and takes out, and grinds as fine powder; Zostera marina is placed in the vinegar that 2.5-3.5 doubly measuresSoak 3-5 hour (vinegar that preferred Zostera marina is placed in 3 times of amounts soaks 4 hours), take out, be placed in micro-wave oven and dry, be ground intoFine powder, mixes with Flos clerodendri japonici fine powder, crosses 80-120 mesh sieve (preferred mistake 100 mesh sieves), obtains mixing fine powders, for subsequent use;

(3) surplus stock medicine is placed in frying pan, adds clear water and decoct twice, add for the first time the clear water that 7-11 doubly measures (preferably firstThe inferior clear water that adds 9 times of amounts), slow fire boiling 0.8-1 hour (preferably slow fire boiling 0.9 hour); Add for the second time that 4.5-7.5 doubly measuresClear water (preferably adding for the second time the clear water of 6 times of amounts), slow fire boiling 36-52 minute (preferably slow fire boiling 45 minutes); Merge twiceDecocting liquid, for subsequent use;

(4) step (3) gained decocting liquid is filtered, filtrate decompression is concentrated into 1/4 of original volume, mix with step (1) gained filtrate,Add step (2) gained mixing fine powders, mix, sterilizing encapsulation, to obtain final product.

The pharmacology of the present invention's main Chinese medicine material used is as follows:

Rhizoma alismatis: base is former: be the stem tuber of Notes On Alism At Aceae rhizoma alismatis. Chemical analysis: separate five kinds of triterpene compounds in stem tuber: rhizoma alismatisAlcohol A, alisol B, acetic acid alisol A ester, acetic acid alisol B ester and epialisol A; Another containing volatile oil (including furfural), in a small amountAlkaloid, asparagine, a plant sterols, a kind of phytosterolin, aliphatic acid (palmitic acid, stearic acid, oleic acid, sub-oilAcid); Also resinous, protein and volume starch. Nature and flavor: sweet, cold. Gui Jing: return kidney, urinary bladder channel. Effect: diuresis, clearing away damp-heat.Cure mainly: for difficult urination. oedema turgor, the oliguria of having loose bowels, phlegmatic vertigo, heat is drenched puckery pain; High fat of blood.

Winter creeper: base is former: be the stem and branch with leaf of Celastraceae plant winter creeper. Chemical analysis: containing dulcitol, seed is containing front westRed persimmon red pigment and front-gamma carotene. Nature and flavor: hardship; Sweet; Micro-pungent; Tepor. Gui Jing: liver; Spleen; Kidney channel. Function cures mainly: relaxing muscles and tendons is livedNetwork; Kidney-nourishing is strengthened waist; The hemostasis stasis of blood that disappears. The main soreness of waist and knee joint of suffering from a deficiency of the kidney; Hemiplegia; Arthralgia due to wind-dampness; Child convulsion; Spitting of blood; Spit blood; BloodCollapse; Have through uncomfortable; The prolapse of uterus; Injury and bone fracture; Traumatic bleeding.

Water three-coloured amaranth: base is former: be the herb of Lythraceae plant roundleaf mexicana. Chemical analysis: containing phenols, amino acid, HuangKetone glucoside. Nature and flavor: sweet light, cool. Function cures mainly: heat-clearing, diuresis, detumescence, removing toxic substances. Control hot dysentery, ascites, gonorrhoea, dysmenorrhoea, hemorrhoid, toothGum swells and ache, carbuncle sore tumefacting virus.

Centipedaplant herb: base is former: be the herb of polygonaceae plant centipedaplant herb. Nature and flavor: sweet; Light; Property is put down. Gui Jing: liver; Lung channel. FunctionCure mainly: clearing heat and detoxicating; Go stagnation resolvation swollen. Main swollen ulcer drug; Traumatic injury; Snake; Insect bite wound.

Siberian elm brak: base is former: be the bark of Ulmaceae elm or the bast of root skin. Chemical analysis: contain cupreol, plantThe multiple sterols such as thing sterol, stigmasterol and tannin, natural gum, fat oil. Nature and flavor: sweet, flat. Gui Jing: 1. " detailed outline ": " brothers tooSun, meridian of Hand-YANG MING. " 2. " book on Chinese herbal medicine is looked for the truth ": " enter stomach, large and small intestines. " function cures mainly: Li Shui, treating stranguria, detumescence. Control urinary obstruction,Stranguria with turbid discharge, oedema, ulcer carbuncle on the back, erysipelas, mange.

Oreas martiana(Hopp. Et Hornsch．) Brid: base is former: be the herb of Dicranaceae plant mountain hair moss. Nature and flavor: sweet; Light; Flat. Gui Jing: the heart; Lung channel. MeritCan cure mainly: replenishing the vital essence and removing heat; Tranquilizing the mind; Dispel rheumatism; Hemostatic analgesia. Main osteopyrexia and fever; Neurasthenia; Rheumatic numbness; Muscles and bonesPain; Demented; Traumatism and bleeding.

Frutus cnidii: base is former: this product is the dry mature fruit of samphire cnidium monnieri. Proterties: this product is diachenium, is ellipseCircular. Surface lark or taupe, there are 2 pieces of bandy base for posts on top, and occasionally there is thin stalk piston part. Nature and flavor: pungent, bitter, temperature; HaveMild toxicity. Gui Jing: return kidney channel. Effect: warming kidney to invigorate yang, eliminating dampness, dispels the wind, desinsection. Cure mainly: for impotence, Gong Leng is under cold-dampness band, wetNumbness pain in the back; Control eczema of vulva outward, married woman's pruritus vulvae, trichomonas vaginitis.

Zostera marina: base is former: be the herb of Potamogetonaceae plant Zostera marina. Pharmacological action: carry from sea-tangle (Zostera marina) with etherA kind of composition going out has inhibitory action to tubercle bacillus. Nature and flavor: taste is salty; Cold in nature. Gui Jing: urinary bladder channel. Function cures mainly: heat-clearingPhlegm; Softening and resolving hard mass; Li Shui. Main goiter and tumor tuberculosis; Hernia lump in the abdomen; Oedema; Beriberi.

Flos clerodendri japonici: base is former: be the flower of Verenaceae Zhi Wu Cheng paulownia. Nature and flavor: sweet; Flat. Gui Jing: the spleen channel. Function cures mainly: peaceGod; Hemostasis. Main palpitation and insomnia; Hemorrhoid hemorrhage.

Omei mountain bamboo juvenile leaf: base is former: the tender leaf of not putting for leaf or the volume of grass cizu. Nature and flavor: sweet; Bitter; Be slightly cold. FunctionCure mainly: diuresis clears away heart-fire; Relieving restlessness is quenched the thirst. Main pyreticosis polydipsia; Scanty drak urine; Aphthae. Loosestrife: base is former: for Primulaceae is plantedRoot or the herb of thing tiger tail loosestrife. Chemical analysis: root is containing multiple saponin, and glucoside unit is the medicinal cherry of primulagenin A and dihydroGrass sapogenin A is camellia sapogenol A. The content of primaverin unit reaches 16%. Seed fatty oily 32.24%. Nature and flavor: pungent puckery,Flat. Gui Jing: liver; The spleen channel. Function cures mainly: clearing heat and promoting diuresis; Promoting blood circulation to remove blood stasis; Removing toxicity for eliminating carbuncles. Main oedema; Heat is drenched; Jaundice; Dysentery; WindDamp-heat arthralgia; Under band; Through closing; Fall and beat; Fracture; Traumatism and bleeding; Acute mastitis; Furunculosis; Snake bite.

Loosestrife: base is former: be root or the herb of Ofthe Primulaceae tiger tail loosestrife. Chemical analysis: containing astragalin, differentQuercitrin, Kaempferol-O-rutinoside and Kaempferol-O-(2,6-bis--O-rhamnopyranosyl) glucopyranoseGlucoside, left-handed epicatechin, 3-O-methyl Quercetin-7-O-[α-L-pyrans rhamnose (1 → 2) glucopyanoside]. PharmacologyEffect: antitumor loosestrife glycosides displayed 625mg/kg lumbar injection, continuous 15 days right to mouse cervical cancer (U14), continuous 8 daysMurine sarcoma-180(S180), EC solid type (ESC) was all had to inhibitory action in continuous 14 days, to mouse ReticulocyteKnurl ascitic type, lymphosarcoma are also effective; Continuous 7 days of 273mg/kg lumbar injection, has inhibitory action to W-256 (W256).Nature and flavor: hardship; Pungent; Property is put down. Gui Jing: liver; The spleen channel. Function cures mainly: clearing heat and promoting diuresis; Promoting blood circulation to remove blood stasis; Removing toxicity for eliminating carbuncles. Main oedema; Heat is drenched;Jaundice; Dysentery; Rheumatic fever numbness; Under band; Through closing; Fall and beat; Fracture; Traumatism and bleeding; Acute mastitis; Furunculosis; Snake bite.

Kuh-seng: base is former: this product is the dry root of legume kuh-seng. Chemical analysis: root contains multiple alkaloid: d-kuh-sengAlkali, d-Oxymatrine, sophoranl l-Anagyrine, l-methylcytisine, l-baptifoline and sophocarpine. Also containing flavonesClass: Xanthohumol, isoxanthohumol etc. Stem, leaf are containing cyanidenon-7-glycoside. Nature and flavor: hardship, cold. Gui Jing: the thoughts of returning home, liver, stomach, largeIntestines, urinary bladder channel. Effect: heat-clearing and damp-drying drug, desinsection, diuresis. Cure mainly: for hot dysentery, have blood in stool. jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva the moonItch, eczema, wet sore, pruitus, mange leprosy; Control trichomonas vaginitis outward.

The sub-bamboo mat spread on the floor for people to sit in ancient China of pheasant: base is former: be the herb of rosaceous plant strawberry cinquefoil root. Nature and flavor: sweet; Temperature. Gui Jing: lung; The spleen channel. FunctionCure mainly: promoting blood circulation and removing blood stasis, replenishing the vital essence and removing heat. Main hernia, a type of tubercular disease found in women.

Long Stephania Herb: base is former: be herb or rhizome and the root of menispermaceous plants Long Stephania Herb. Chemical analysis: Long Stephania Herb root is containing thousandGold rattan ripple woods alkali, longanine, longanone, cycleanine, homoaromoline alkali, the Japanese Stephania Root alkali of worshipping stars, former Japanese Stephania RootThe alkali of worshipping stars. Nature and flavor: hardship; Cold. Gui Jing: liver; Courage; Large intestine channel. Function cures mainly: clearing heat and detoxicating; Inducing diuresis and reducing edema; Dispelling, collateral-activating. Main rushing downDysentery; Urine leaching is puckery; Oedema; Jaundice; Arthralgia due to wind-dampness; Larynx numbness; Ting ear; Sore and toxic; Venomous snake bite.

Shorthairy Antenoron: base is former: be the herb of orchid Anoectochilus Roxburghii and Shorthairy Antenoron. Chemical analysis: Shorthairy Antenoron is containing moreThe fat (fat) of amount and vitamin (vitamin) C, also containing mineral element (mg/kg) calcium 279, phosphorus 193, potassium 806, sodium 18, magnesium270, iron 51.7, manganese 13.8, zinc 9.3, copper 2.6. Pharmacological action: 1. hepatoprotective effect Shorthairy Antenoron water extract rats by intraperitoneal injectionCan obviously reduce the SAIT that caused by tetrachloro carbon (CCl4) and the acute rising of aspartate transaminase, gold threadBlue treatment can improve liver histological simultaneously and change, such as necrosis, steatosis, ballooning degeneration, lymphocyte and withered no thinArteries and veins inflammatory around in Bao center oozes out. 2. antiinflammatory action rats by intraperitoneal injection Shorthairy Antenoron water extract is giving carrageenanRear 4h starts to show delaying property anti-inflammatory activity. Someone to three kinds of differences not the Shorthairy Antenoron in source (wild, artificial cultivation, tissue are cultivatedShorthairy Antenoron) carry out antiinflammatory action comparison, the Shorthairy Antenoron decocting liquid of three kinds of separate sources all shows certain antiinflammatory action as a result.Nature and flavor: sweet; Cool. Gui Jing: lung; Liver; Kidney; Urinary bladder channel. Function cures mainly: clearing heat and cooling blood; Removing dampness and detoxicating. Main lung heat hemoptysis; Pulmonary tuberculosisSpitting of blood; Hematuria; Child convulsion; Lockjaw; Nephritic dropsy; Arthralgia due to wind-dampness; Traumatic injury.

A kind of preparation that cures mainly external piles provided by the invention, prescription science, preparation method is simple, evident in efficacy. Remove this itOutward, excellent results of the present invention also shows:

1, the present invention uses theory of traditional Chinese medical science analysis prescription composition, according to the physicochemical property of each flavour of a drug ingredient and pharmacological actionResult of study, research has obtained the preparation method of reasonable, stable active component;

2, medicine of the present invention, by science compatibility, complements each other, and has bactericidal antiphlogistic, astringing to arrest bleeding, and effect of swelling and pain relieving, treatsEffect is stable, safe without toxic side effect;

3, medicine source is easy to get, and medicinal material is with low cost, can relieve patient ' s burden.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.

1 one kinds of embodiment cure mainly the preparation of external piles, are prepared from by following bulk drugs, are weight portion (150g/ part):6 parts of rhizoma alismatis; 10 parts of winter creepers; 6 parts of water three-coloured amaranths; 4 parts of centipedaplant herbs; 5 parts of Siberian elm brak; 10 parts of Oreas martiana(Hopp. Et Hornsch．) Brids; 3.5 parts of frutus cnidiis; great Ye4 parts, algae; 2 parts of Flos clerodendri japonicis; 3.5 parts of omei mountain bamboo juvenile leafs; 7 parts of loosestrives; 5 parts of kuh-sengs; 3 parts of the sub-bamboo mats spread on the floor for people to sit in ancient China of pheasant; 2.5 parts of Long Stephania Herbs; Shorthairy Antenoron 4Part.

A kind of preparation method of ointment of the preparation that cures mainly external piles is:

(1) Siberian elm brak, winter creeper and kuh-seng fully be dry, pulverize into fine powder, cross 30 mesh sieves, obtain mixing fine powders, gained is mixedClose fine powder and immerse in sesame oil, under normal temperature, soak 2 days, after centrifuge is centrifugal, get supernatant liquor for subsequent use;

(2) to the butter that adds 0.15 times of amount in frutus cnidii, mix thoroughly, little fire is fried to butter and is exhausted, and has fragrance to overflow, and takes out, standbyWith;

(4) by step (3) gained meal, be placed in percolator, the ethanol taking concentration as 50%, as solvent, carries out according to percolationDiacolation, collects percolate, filters, and filtrate, after reclaiming ethanol, is mixed with step (1) gained supernatant, is evaporated to 80 DEG CRelative density is the thick paste of 1.32-1.35, for subsequent use;

(5) to adding ointment bases in step (4) gained thick paste, (described ointment bases is the lanolin and 1.1 of 0.6 times of thick paste amountThe vaseline of times thick paste amount), mix, sterilizing encapsulation, to obtain final product.

The using method of gained ointment of the present invention is: clean affected part with clear water, and external application, a 1-1.5 gram, 2 times on the one,It within 7 days, is a course for the treatment of.

2 one kinds of embodiment cure mainly the preparation of external piles, are prepared from by following bulk drugs, are weight portion (110g/ part):10 parts of rhizoma alismatis; 13 parts of winter creepers; 8 parts of water three-coloured amaranths; 7 parts of centipedaplant herbs; 9 parts of Siberian elm brak; 12 parts of Oreas martiana(Hopp. Et Hornsch．) Brids; 6.5 parts of frutus cnidiis; great Ye7 parts, algae; 5 parts of Flos clerodendri japonicis; 6.5 parts of omei mountain bamboo juvenile leafs; 11 parts of loosestrives; 9 parts of kuh-sengs; 6 parts of the sub-bamboo mats spread on the floor for people to sit in ancient China of pheasant; 5.5 parts of Long Stephania Herbs; Shorthairy Antenoron 6Part.

A kind of preparation method of tablet of the preparation that cures mainly external piles is:

(1) to the butter that adds 0.25 times of amount in frutus cnidii, mix thoroughly, little fire is fried to butter and is exhausted, and has fragrance to overflow, and takes out, and grindsFor fine powder, for subsequent use;

(2) kuh-seng, Siberian elm brak, Long Stephania Herb and loosestrife are mixed, be placed in frying pan, add the clear water of 8.5 times of amounts, slow fire boiling 60Minute, to filter, filtrate decompression is condensed into thick paste, and spraying is dry, and the powder that gets dry extract is for subsequent use;

(3) after surplus stock medicine is fully dry, be placed in pulverizer and be ground into fine powder, with step (1) gained fine powder and step(2) gained dried cream powder mixes, and crosses 65 mesh sieves, and (described auxiliary material is that mass fraction is that 3.3% talcum powder and quality are divided to add auxiliary materialNumber is 1.7% stearic acid), stir, be pressed into tablet, to obtain final product.

The instructions of taking of gained tablet of the present invention is: every day three times, and each 3-4 sheet, warm water takes, and within 7 days, is a course for the treatment of.

Model case: old XX, man, 20 years old, student. Patient's readme: before 2 days, there is the anus symptom that swells and ache without obvious inducement,When defecation, pain increases the weight of, and July 19 in 2013, Lai Wo institute checked treatment. Check: there is a swollen thing at patient's anus place, is livid purpleLook, surrounding skin redness, the pain of touching is strong, and nearly one week of patient is because being hard and dry, the defecation of repeatedly exerting oneself. Through clinical symptoms and realityTest chamber inspection and be diagnosed as inflammatory external hemorrhoid. Take the tablet of a kind of preparation that cures mainly external piles of the present embodiment gained, instructions of taking: every dayThree times, each 3-4 sheet, warm water takes, and within 7 days, is a course for the treatment of. Treat after two courses for the treatment of, patient's malaise symptoms is all eliminated, fromSense recovery from illness. During medication, patient reacts without any discomfort, and drug withdrawal was paid a return visit after three months, without recurrence.

3 one kinds of embodiment cure mainly the preparation of external piles, are prepared from by following bulk drugs, are weight portion (140g/ part):7 parts of rhizoma alismatis; 11 parts of winter creepers; 6.5 parts of water three-coloured amaranths; 5 parts of centipedaplant herbs; 6 parts of Siberian elm brak; 10.5 parts of Oreas martiana(Hopp. Et Hornsch．) Brids; 4.5 parts of frutus cnidiis;5 parts of Zostera marinas; 3 parts of Flos clerodendri japonicis; 4.5 parts of omei mountain bamboo juvenile leafs; 8 parts of loosestrives; 6 parts of kuh-sengs; 4 parts of the sub-bamboo mats spread on the floor for people to sit in ancient China of pheasant; 3.5 parts of Long Stephania Herbs; Gold threadBlue 4.5 parts.

A kind of preparation method of capsule of the preparation that cures mainly external piles is:

(1) rhizoma alismatis, Zostera marina, kuh-seng, the sub-bamboo mat spread on the floor for people to sit in ancient China of pheasant, Oreas martiana(Hopp. Et Hornsch．) Brid and winter creeper are mixed, be ground into fine powder through plant pulverizer, mistake60 mesh sieves, the ethanolic solution that the concentration that is placed in 50 DEG C is 55% soaks 2.5 hours, and the ultrasonic wave that is then 420W through power is carriedGet tank and extract 45 minutes, extract, after centrifugal, is collected supernatant liquor;

(3) to the butter that adds 0.25 times of amount in frutus cnidii, mix thoroughly, little fire is fried to butter and is exhausted, and has fragrance to overflow, and takes out, and grindsFor fine powder, for subsequent use; Flos clerodendri japonici is placed in medicine cookeding pot, and little fire stir-fries 8 minutes, and the yellow rice wine of 0.34 times of described raw material dose of spray, continuesContinuous stir-fry to yellow rice wine is sucked, and takes out, and grinds as fine powder, for subsequent use;

(4) surplus stock medicine fully be dry, pulverize into fine powder, mix with step (3) gained fine powder, cross 85 mesh sieves, joinIn the clear cream of step (2) gained, mix, granulate, dry, whole grain, incapsulates shell, to obtain final product.

The instructions of taking of gained capsule of the present invention is: every day three times, and each 2-3 grain, warm water takes, and within 7 days, is a treatmentJourney.

4 one kinds of embodiment cure mainly the preparation of external piles, are prepared from by following bulk drugs, are weight portion (120g/ part):9 parts of rhizoma alismatis; 12 parts of winter creepers; 7.5 parts of water three-coloured amaranths; 6 parts of centipedaplant herbs; 8 parts of Siberian elm brak; 11.5 parts of Oreas martiana(Hopp. Et Hornsch．) Brids; 5.5 parts of frutus cnidiis;6 parts of Zostera marinas; 4 parts of Flos clerodendri japonicis; 5.5 parts of omei mountain bamboo juvenile leafs; 10 parts of loosestrives; 8 parts of kuh-sengs; 5 parts of the sub-bamboo mats spread on the floor for people to sit in ancient China of pheasant; 4.5 parts of Long Stephania Herbs; Gold threadBlue 5.5 parts.

A kind of preparation method of lotion of the preparation that cures mainly external piles is:

(1) kuh-seng, rhizoma alismatis and Siberian elm brak mix, and are placed in Chinese medicament extracting device, and the ethanol taking concentration as 65%, as solvent, heats backStream extracts twice, and each each extraction 35 minutes, merges extracted twice liquid, filter, and filtrate recycling ethanol, for subsequent use;

(2) Flos clerodendri japonici is placed in medicine cookeding pot, and little fire stir-fries 8 minutes, and the yellow rice wine of 0.34 times of described raw material dose of spray continues to fry extremelyYellow rice wine is sucked, and takes out, and grinds as fine powder; The vinegar that Zostera marina is placed in 3 times of amounts soaks 4 hours, takes out, and is placed in micro-wave oven roastingDry, be ground into fine powder, mix with Flos clerodendri japonici fine powder, cross 100 mesh sieves, obtain mixing fine powders, for subsequent use;

(3) surplus stock medicine is placed in frying pan, adds clear water and decoct twice, add for the first time the clear water of 9 times of amounts, slow fire boiling 0.9Hour; Add for the second time the clear water of 6 times of amounts, slow fire boiling 45 minutes; Merge decocting liquid twice, for subsequent use;

The using method of gained lotion of the present invention is: with after clear water cleaning affected part, be stained with liquid clean affected part, every day with gauze2 times, each scouring once, 7 days is a course for the treatment of sooner or later.

Model case: Liu XX, female, 33 years old, bank clerk. Patient's readme: anus pain is had a surplus on the 7th, stool is not understood, and sitsRestless sleep. Be diagnosed as inflammatory external hemorrhoid at local certain examination in hospital. Medicine treatment, after 3 days, is defecated to such an extent that separate, but anus swells and ache, symptom is notSee and alleviate. Patient introduces through colleague, and April 13 in 2014, Lai Wo institute checked treatment. Check: patient's anus lithotomy position oedema is sent outBright, look purplish red, and the pain of touching is obvious, is diagnosed as inflammatory external hemorrhoid. Use washing of a kind of preparation that cures mainly external piles of the present embodiment gainedAgent, using method: with after clear water cleaning affected part, be stained with liquid with gauze and clean affected part, every day 2 times, each scouring once sooner or later, 7 daysIt is a course for the treatment of. Treat after the course for the treatment of, patient's readme anus pain obviously alleviates, and oedema disappears, a course for the treatment of of continual cureAfter, all cards of patient are eliminated, self-induction recovery from illness. During medication, patient reacts without any discomfort, and drug withdrawal was paid a return visit after three months, without recurrence.

5 one kinds of embodiment cure mainly the preparation of external piles, are prepared from by following bulk drugs, are weight portion (130g/ part):8 parts of rhizoma alismatis; 11.5 parts of winter creepers; 7 parts of water three-coloured amaranths; 5.5 parts of centipedaplant herbs; 7 parts of Siberian elm brak; 11 parts of Oreas martiana(Hopp. Et Hornsch．) Brids; 5 parts of frutus cnidiis; Greatly5.5 parts, leaf algae; 3.5 parts of Flos clerodendri japonicis; 5 parts of omei mountain bamboo juvenile leafs; 9 parts of loosestrives; 7 parts of kuh-sengs; 4.5 parts of the sub-bamboo mats spread on the floor for people to sit in ancient China of pheasant; 4 parts of Long Stephania Herbs; Gold threadBlue 5 parts.

(1) Siberian elm brak, winter creeper and kuh-seng fully be dry, pulverize into fine powder, cross 45 mesh sieves, obtain mixing fine powders, gained is mixedClose fine powder and immerse in sesame oil, under normal temperature, soak 3 days, after centrifuge is centrifugal, get supernatant liquor for subsequent use;

(2) to the butter that adds 0.25 times of amount in frutus cnidii, mix thoroughly, little fire is fried to butter and is exhausted, and has fragrance to overflow, and takes out, standbyWith;

(4) by step (3) gained meal, be placed in percolator, the ethanol taking concentration as 60%, as solvent, carries out according to percolationDiacolation, collects percolate, filters, and filtrate, after reclaiming ethanol, is mixed with step (1) gained supernatant, is evaporated to 80 DEG CRelative density is the thick paste of 1.32-1.35, for subsequent use;

The application study of a kind of preparation (embodiment 5) that cures mainly external piles of test example gained of the present invention:

1, physical data

Choose the 340 exception hemorrhoid patients that Wo Yuangang intestines section accepts for medical treatment from September, 2012-2014 year July, wherein male patient totally 218Example, female patient is totally 122 examples, and the age, the course of disease was the shortest 3 days, the longest 42 days in 20-50 year. All patients are all with reference to " the Chinese peopleRepublic's traditional Chinese medicine professional standard " be diagnosed as external piles, wherein inflammatory external hemorrhoid patient 163 examples, varication external piles 65 examples, thrombusProperty external piles 67 examples, knot is formed group group external piles 45 examples. All patients are divided into experimental group and control group at random, and two groups of patients are in age, propertyNot, the aspect comparing difference not statistically significant (P > 0.05) such as the state of an illness, there is comparativity.

2, methods for the treatment of

Experimental group is used gained of the present invention a kind of preparation that cures mainly external piles, using method: clean affected part with clear water, and external application, once1-1.5 gram, 2 times on the one 7 days is a course for the treatment of. Control group uses other medicine (as Yunnan Baiyao acne cream, HUAZHI SHUAN, fargelinThe conventional medicine such as sheet). Treat altogether three courses for the treatment of.

3, efficacy assessment standard

With reference to " disease of tcm Standardization of diagnosis and curative effect ", experimental group and control group patient treatment result are evaluated.

Cure: anus foreign body sensation, falling inflation pain, have blood in stool, deviate from, the transference cure such as rotten to the corn, the complete atrophy of haemorrhoids;

Take a turn for the better: anus foreign body sensation falling inflation pain, have blood in stool, deviate from, the symptom such as rotten to the corn significantly improves, haemorrhoids obviously dwindles;

Invalid: clinical symptoms and sign are without improving or worsening.

Total effective rate=(curing number of cases+improvement number of cases)/total inspection case load × 100%.

4, result for the treatment of

All data acquisitions are processed with SPSS19.0 statistical software, and enumeration data adopts X²Inspection, P < 0.05 represents that difference hasStatistical significance. Result is as shown in table 1.

Table 1: experimental group and control group patient's treatment results

Result for the treatment of: experimental group is cured 146 examples (76.8%), 42 examples that take a turn for the better (22.1%), invalid 2 examples (1.1%), total effective rate is98.9%. And control group total effective rate is 83.3%. Two groups of total effective rate comparisons, experimental group is obviously better than control group, and difference has systemMeter is learned meaning (P < 0.05).

The present invention selects the totally 15 taste primary raw material medicines such as rhizoma alismatis, winter creeper, water three-coloured amaranth, centipedaplant herb, Siberian elm brak and Oreas martiana(Hopp. Et Hornsch．) BridBe prepared from. Fang Zhong, rhizoma alismatis clearing away damp-heat; The winter creeper hemostasis stasis of blood that disappears; Water three-coloured amaranth reducing fever and causing diuresis, subdhing swelling and detoxicating; Centipedaplant herb goes stagnation resolvationSwollen; Siberian elm brak inducing diuresis for removing edema; Oreas martiana(Hopp. Et Hornsch．) Brid hemostatic analgesia; Frutus cnidii dispels the wind, desinsection; The Flos clerodendri japonici hemostasis of calming the nerves; Omei mountain bamboo juvenile leaf removing toxic substances disappearsCarbuncle; Kuh-seng heat-clearing and damp-drying drug, desinsection diuresis; Long Stephania Herb is clearing heat and detoxicating, inducing diuresis and reducing edema. Full side's compatibility, only plays astringing to arrest bleeding, anti-inflammatory altogetherThe merit of pain. In experimental group, treat three courses for the treatment of, total effective rate is 98.9%, evident in efficacy.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious skill of the present inventionArt scheme is not limited to above-described embodiment, can also have a lot of distortion. Those of ordinary skill in the art, clear and definite public with the present invention instituteThat open or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.

Claims

1. a preparation that cures mainly external piles, is characterized in that, is prepared from by following bulk drugs, is weight portion: rhizoma alismatis 6-10;Winter creeper 10-13; Water three-coloured amaranth 6-8; Centipedaplant herb 4-7; Siberian elm brak 5-9; Oreas martiana(Hopp. Et Hornsch．) Brid 10-12; Frutus cnidii 3.5-6.5; Zostera marina 4-7; Flos clerodendri japonici 2-5; Omei mountain bamboo juvenile leaf 3.5-6.5; Loosestrife 7-11; Kuh-seng 5-9; The sub-bamboo mat spread on the floor for people to sit in ancient China 3-6 of pheasant; Long Stephania Herb 2.5-5.5; Shorthairy Antenoron 4-6。

2. a kind of preparation that cures mainly external piles as claimed in claim 1, is characterized in that, is prepared from, all by following bulk drugsFor weight portion: rhizoma alismatis 7-9; Winter creeper 11-12; Water three-coloured amaranth 6.5-7.5; Centipedaplant herb 5-6; Siberian elm brak 6-8; Oreas martiana(Hopp. Et Hornsch．) Brid 10.5-11.5; Frutus cnidii 4.5-5.5; Zostera marina 5-6; Flos clerodendri japonici 3-4; Omei mountain bamboo juvenile leaf 4.5-5.5; Loosestrife 8-10; Kuh-seng 6-8; PheasantBamboo mat spread on the floor for people to sit in ancient China 4-5; Long Stephania Herb 3.5-4.5; Shorthairy Antenoron 4.5-5.5.

3. a kind of preparation that cures mainly external piles as claimed in claim 1, is characterized in that, is prepared from, all by following bulk drugsFor weight portion: rhizoma alismatis 8; Winter creeper 11.5; Water three-coloured amaranth 7; Centipedaplant herb 5.5; Siberian elm brak 7; Oreas martiana(Hopp. Et Hornsch．) Brid 11; Frutus cnidii 5; Zostera marina5.5; Flos clerodendri japonici 3.5; Omei mountain bamboo juvenile leaf 5; Loosestrife 9; Kuh-seng 7; The sub-bamboo mat spread on the floor for people to sit in ancient China 4.5 of pheasant; Long Stephania Herb 4; Shorthairy Antenoron 5.

4. the preparation method of the ointment of a kind of preparation that cures mainly external piles as described in as arbitrary in claim 1-3, is characterized in that,Step is as follows:

5. the preparation method of the ointment of a kind of preparation that cures mainly external piles according to claim 4, is characterized in that, step(5) ointment bases described in is the lanolin of 0.6 times of thick paste amount and the vaseline of 1.1 times of thick paste amounts.

6. the preparation method of the tablet of a kind of preparation that cures mainly external piles as described in as arbitrary in claim 1-3, is characterized in that, stepRapid as follows:

7. according to the preparation method of the tablet of the arbitrary described a kind of preparation that cures mainly external piles of claim 1-3, it is characterized in that,Auxiliary material described in step (3) is that mass fraction is the stearic acid that 3.3% talcum powder and mass fraction are 1.7%.

8. the preparation method of the capsule of a kind of preparation that cures mainly external piles as described in as arbitrary in claim 1-3, is characterized in that,Step is as follows:

9. the preparation method of the capsule of a kind of preparation that cures mainly external piles according to claim 8, is characterized in that, step(3) in, the amount of yellow rice wine is that doubly (amount of preferred yellow rice wine is the 0.32-of described raw material dose for the 0.28-0.4 of described raw material dose0.36 times, the amount of the yellow rice wine being more preferably is 0.34 times of described raw material dose).

10. the preparation method of the lotion of a kind of preparation that cures mainly external piles as described in as arbitrary in claim 1-3, is characterized in that,Step is as follows: