CN105560582A - Swelling eliminating and itch relieving ointment for treating chilblain and preparation method thereof - Google Patents
Swelling eliminating and itch relieving ointment for treating chilblain and preparation method thereof Download PDFInfo
- Publication number
- CN105560582A CN105560582A CN201610009218.2A CN201610009218A CN105560582A CN 105560582 A CN105560582 A CN 105560582A CN 201610009218 A CN201610009218 A CN 201610009218A CN 105560582 A CN105560582 A CN 105560582A
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- parts
- radix
- chilblain
- crude drug
- herba
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a swelling eliminating and itch relieving ointment for treating chilblain. The ointment is prepared from the following raw materials in parts by weight: 8 to 13 parts of eggplant root, 6 to 12 parts of radermachera sinica, 4 to 9 parts of dominant pulicaria flower, 7 to 11 parts of euonymus bungeanus, 5 to 10 parts of bearded mallotus leaf, 3 to 8 parts of hovenia acerba leaf, 6 to 11 parts of alligator weed, 4 to 7 parts of tetrapanax papyriferus, 8 to 11 parts of longstamen loosestrife herb, 6 to 13 parts of Chinaberry bark, 8 to 12 parts of actinidia eriantha leaf, 6 to 10 parts of helleborus thibetanus, 4 to 11 parts of garcinia multiflora, 7 to 12 parts of pteris semipinnata, and 5 to 11 parts of impatiens leptocaulon. The formula is scientific, the traditional Chinese herbals generate a synergetic effect, and the ointment has the functions of dissipating stasis, eliminating swelling, regulating qi, and activating blood, and has the advantages of good curative effect, relapse prevention, and rapid effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of repellent antipruritic ointment and method for making for the treatment of chilblain.
Background technology
Chilblain is common in winter, and due to local skin erythema, the tumidus infringement repeatedly that very cold causes, vesicle, ulcer can appear in severe patient, and the course of disease is slow, and weather turns warm rear spontaneous recovery, easily recurs.Cold is the main cause of chilblain morbidity.Its pathogenic factor be the skin of chilblain patient when running into cold (0 ~ 10 DEG C), the moist or changes in temperature sudden turn of events, local small artery shrinks, arteries paralysis of a specified duration and expanding, venous congestion, and local blood circulation is bad and fall ill.Chilblain is apt to occur in early winter, early spring, and with child, women and peripheral blood circulation, bad person is common, the performances such as these patients often send out cool with acral body skin, acrocyanosis, hyperhidrosis.Skin lesion is apt to occur in the places such as finger, the back of the hand, face, auricle, toes, sufficient edge, heel, the distribution of normal both sides.Common infringement is the edematous erythema of the congestive dark violet redness protuberance of limitation, and indefinite border, edge is cerise, and surface is nervous glossy, and matter is soft.Local pressing can be faded, and goes to press rear redness to recover gradually.Can there is vesicle in severe patient, break and form rotten to the corn or ulcer, retain pigmentation or atrophic scar more afterwards.Gargalesthesia is obvious, aggravates after heated, pain after festering.
Publication No. CN104666573A(application number 201310633158.8) Chinese patent literature disclose treatment chilblain Chinese medicine.Described medicine is made up of following raw material: Ramulus Cinnamomi, the Radix Rehmanniae, Herba Asari, Ganoderma, Radix Ginseng, Radix Notoginseng Flos Carthami.Publication No. CN103393951A(application number 201310352909.9) Chinese patent literature disclose treatment chilblain medication chilblain tincture.This chilblain tincture forms with alcohol-pickled with Cortex Dictamni, Radix Et Rhizoma Rhei, the Pseudobulbus Bletillae (Rhizoma Bletillae), Ramulus Cinnamomi, Flos Carthami, Radix Angelicae Sinensis and Radix Angelicae Dahuricae kinds of traditional Chinese medicines, wherein 75% ethanol of 1000ml is joined the dosage of each taste Chinese medicine and is: Cortex Dictamni 30-50g, Radix Et Rhizoma Rhei 20-30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30-40g, Ramulus Cinnamomi 20-30g, Flos Carthami 20-30g, Radix Angelicae Sinensis 30-40g, Radix Angelicae Dahuricae 10-20g.Publication No. CN104523760A(application number 201410771958.0) Chinese patent literature disclose a kind of quick-acting chilblain ointment, have the raw material of following weight portion to make: chicken oil 3-6 part, Cera Flava 1-3 part, heparin sodium aqua 1-2 part.Preparation method comprises the following steps: by chicken oil heating and melting; At oil temperature 60-70 DEG C, add Cera Flava and heparin sodium aqua stirs into paste, mastic is packaged into box.
The medicine of current treatment chilblain, for the chilblain that symptom is lighter, remission effect is good, but can not thoroughly cure, the patient that especially chilblain is serious, and relapse rate is higher, therefore needs the curative effect improving treatment chilblain medicine further.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of curative effect is reliable, take safe treatment chilblain repellent antipruritic ointment and method for making.
Technical scheme of the present invention is:
The repellent antipruritic ointment for the treatment of chilblain, is prepared from primarily of following bulk drugs, is mass parts: Radix Solani Melongenae 8-13, Radix radermacherae sinicae 6-12, Pulicaria insignis Drumm. 4-9, Herba Euonymi Bungeani 7-11, Folium Malloti barbati 5-10, Folium Hoveniae 3-8, Radix Alternantherae philoxeroidis 6-11, Medulla Tetrapanacis 4-7, Herba Lysimachiae Lobelioidis 8-11, Cortex Meliae 6-13, Radix Actinidiae Erianthae leaf 8-12, Radix Chimonanthi praecocis 6-10, Fructus Garciniae oblongifoliae 4-11, Herba Pteridis Semipinnatae 7-12, Impatiens leptocaulon Hook.f. 5-11.
Preferred version is, Radix Solani Melongenae 10-11, Radix radermacherae sinicae 8-10, Pulicaria insignis Drumm. 5-8, Herba Euonymi Bungeani 8-10, Folium Malloti barbati 6-9, Folium Hoveniae 4-7, Radix Alternantherae philoxeroidis 7-10, Medulla Tetrapanacis 5-6, Herba Lysimachiae Lobelioidis 9-10, Cortex Meliae 8-11, Radix Actinidiae Erianthae leaf 9-11, Radix Chimonanthi praecocis 7-9, Fructus Garciniae oblongifoliae 6-9, Herba Pteridis Semipinnatae 9-10, Impatiens leptocaulon Hook.f. 7-9.
More preferably, Radix Solani Melongenae 10.5, Radix radermacherae sinicae 9, Pulicaria insignis Drumm. 6.5, Herba Euonymi Bungeani 9, Folium Malloti barbati 7.5, Folium Hoveniae 5.5, Radix Alternantherae philoxeroidis 8.5, Medulla Tetrapanacis 5.5, Herba Lysimachiae Lobelioidis 9.5, Cortex Meliae 9.5, Radix Actinidiae Erianthae leaf 10, Radix Chimonanthi praecocis 8, Fructus Garciniae oblongifoliae 7.5, Herba Pteridis Semipinnatae 9.5, Impatiens leptocaulon Hook.f. 8.
The preparation method of the repellent antipruritic ointment of described treatment chilblain, step is as follows:
(1) get Radix radermacherae sinicae and Fructus Garciniae oblongifoliae to clean and dry, be placed in parch container, slow fire stir-fry 6-12 minute (preferred: slow fire stir-fries 8-10 minute; Be more preferably: slow fire stir-fries 9 minutes), take out and mix with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add soaking in rice vinegar, little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 30-50 minute (preferably: soak 35-45 minute; Be more preferably: soak 40 minutes), mix thoroughly with Sal after taking-up, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mixes, pulverize and sieve, make medicated powder with step (1) (2) made crude drug;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix, add alcoholic solution, reflux, extract, twice with step (3) made medicated powder, it is (preferred: extraction time is 45-55 minute at every turn that each extraction time is 40-60 minute; Be more preferably: each extraction time is 50 minutes), filter, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, and add vaseline and Adeps Sus domestica mixing, heated and stirred is even, and furnishing paste, must treat the repellent antipruritic ointment of chilblain.
The preparation method of the repellent antipruritic ointment of described treatment chilblain, step (1) is the 1-2 of crude drug quality doubly (preferred: to be 1.5 times of crude drug quality with rice vinegar amount) with rice vinegar amount.
The preparation method of the repellent antipruritic ointment of described treatment chilblain, step (2) Steam by water bath 16-28 minute is (preferred: Steam by water bath 20-24 minute; Be more preferably: Steam by water bath 22 minutes).
The preparation method of the repellent antipruritic ointment of described treatment chilblain, it is that the 0.2-0.5 of crude drug quality is doubly (preferred: to add 0.3-0.4 times that salinity is crude drug quality that step (3) adds salinity; Be more preferably: add 0.35 times that salinity is crude drug quality).
The preparation method of the repellent antipruritic ointment of described treatment chilblain, it is (preferred: to pulverize 90-110 mesh sieve that step (3) pulverized 70-130 mesh sieve; Be more preferably: pulverized 100 mesh sieves).
The preparation method of the repellent antipruritic ointment of described treatment chilblain, the consumption that step (4) adds alcoholic solution by extraction crude drug quality 7-9 doubly (preferred: the consumption adding alcoholic solution by 7.5-8.5 times of extractions crude drug quality; Be more preferably: the consumption adding alcoholic solution by 8 times of extraction crude drug quality).
The preparation method of the repellent antipruritic ointment of described treatment chilblain, it is (preferred: heating-up temperature is 60-70 DEG C that step (5) heating-up temperature is 50-80 DEG C; Be more preferably: heating-up temperature is 65 DEG C).
The repellent antipruritic ointment not only scientific formula for the treatment of chilblain provided by the invention, and preparation method is simple, product taking convenience.In addition, excellent results of the present invention also shows:
1, products obtained therefrom therapeutic effect of the present invention is good, instant effect, effectively can prevent recurrence;
2, this prescription meets Chinese medicine principle completely, has the effect such as dissipating blood stasis for subsidence of swelling, vital energy regualting and blood circulation-promoting;
3, raw material of the present invention is Chinese medicinal plant material, and cheap and easy to get, cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Solani Melongenae: base is former: be the root of plant of Solanaceae eggplant.Nature and flavor: sweet in the mouth; Pungent; Cold in nature.Function cures mainly: expelling wind and removing dampness; Clearing away heat to stop bleeding.Main air damp-heat arthralgia; Foot gas; Dysentery; Have blood in stool; Hemorrhoidal bleeding; Stranguria with blood; Women's pudendal pruritus; Skin pruritus; Chilblain.
Radix radermacherae sinicae: base is former: be the root of Bignoniaceae plant Radix radermacherae sinicae, leaf or fruit.Nature and flavor: bitter in the mouth; Cold in nature.Function cures mainly: summer heat clearing toxin resolving; Dissipating blood stasis for subsidence of swelling.Main Sunstroke heating; Carbuncle; Injury and bone fracture; Venom.
Pulicaria insignis Drumm.: base is former: be flower or the herb of the smelly fleabane of feverfew.Nature and flavor: bitter in the mouth; Cold in nature.Function cures mainly: clearing away the hectic fever; Removing pathogenic heat from blood and toxic substance from the body.Main pulmonary tuberculosis cough; Hectic fever due to YIN-deficiency consumptive fever; Swollen ulcer drug; Erysipelas; Rubella pruritus.
Herba Euonymi Bungeani: base is former: be root, the bark of Celastraceae vegetable silk Populus deltoides.Nature and flavor: bitter; Pungent; Cool.Gui Jing: liver; Spleen; Kidney channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances hemostasis.Main air wet arthritis; Lumbago; Traumatic injury wound is swollen; Thromboangiitis obliterans; Lung abscess; Epistaxis; Furuncle toxic swelling.
Folium Malloti barbati: base is former: be the leaf of euphorbia plant Mallotusbarbatus(Wall.exBaill.)Muell.-Arg..Nature and flavor: bitter; Cold.Gui Jing: Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing to stop itchin; Cooling blood for hemostasis.Main decubital ulcer; Ulcer of the lower limb; Eczema; Back of the body tinea; Dermatitis rhus; Traumatic hemorrhage.
Folium Hoveniae: base is former: be the leaf of Rhamnaceae plant Semen Hoveniae, Semen Hoveniae (Fructus Hoveniae) and comospore Semen Hoveniae (Fructus Hoveniae).Nature and flavor: bitter in the mouth; Cool in nature.Gui Jing: stomach; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Relieving restlessness is quenched the thirst.Main anemopyretic cold; Drunk excessive thirst; Vomiting; Constipation.
Radix Alternantherae philoxeroidis: base is former: be the herb of amaranthaceous plant Alternanthera philoxeroides.Nature and flavor: bitter; Sweet; Cold in nature.Gui Jing: lung; The heart; Liver; Urinary bladder channel.Function cures mainly: clearing away heat and cooling blood; Removing toxic substances; Diuresis.Main hemoptysis; Hematuria; Cold, fever; Measles; Encephalitis B; Jaundice; Stranguria with turbid discharge; Mumps; Eczema; Carbuncle furuncle; Venom.
Medulla Tetrapanacis: base is former: be the stem pith of Araliaceae rice-paper plant.Nature and flavor: sweet in the mouth; Light; Cold nature.Nature and flavor: sweet in the mouth; Light; Cold nature.Function cures mainly: clear snobbish water; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.
Herba Lysimachiae Lobelioidis: base is former: be the herb of the long stamen Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) of Ofthe Primulaceae.Nature and flavor: sweet; Property is put down.Gui Jing: lung; The heart; Liver Channel.Function cures mainly: tonify deficiency cough-relieving; Subduing swelling and detoxicating; Hemostasia and promoting granulation.The main deficiency of the lung; Cough; Acute mastitis; Knife injury is hemorrhage.
Cortex Meliae: base is former: be bark and the root bark of Meliaceae plant chinaberry and Fructus Toosendan.Nature and flavor: bitter; Cold; Poisonous.Gui Jing: spleen; Stomach; Liver Channel.Function cures mainly: parasite killing; Treat tinea.Main ascariasis; Ancylostomiasis; Enterobiasis; Trichomonal vaginitis; Scabies; Tinea capitis.
Radix Actinidiae Erianthae leaf: base is former: be the leaf of Actinidiaceae actinidia actinidia eriantha.The property of medicine: micro-bitter, acrid, cold.Function cures mainly: subduing swelling and detoxicating, hemostasis blood stasis dispelling.Cure mainly swollen ulcer drug, acute mastitis, traumatic injury, fracture, knife injury, chilblain diabrosis.
Radix Chimonanthi praecocis: base is former: be the root of Calycanthaceae wax prunus mume (sieb.) sieb.et zucc..Nature and flavor: acrid in the mouth; Warm in nature; Poisonous.Gui Jing: liver; Lung meridian.Function cures mainly: wind-expelling pain-stopping; Vital energy regualting and blood circulation-promoting; Relieving cough and asthma.Main air pain of dampness syndrome; Anemofrigid cold; Traumatic injury; Epigastric pain; Asthma; Epersalgia cough; Furuncle swelling toxin.
Fructus Garciniae oblongifoliae: base is former: be the fruit of Garcinia maingayii Fructus Garciniae oblongifoliae and south of the Five Ridges Cortex Garciniae.Nature and flavor: sweet; Cool.Gui Jing: spleen channel.Function cures mainly: heat clearing away; Promote the production of body fluid.Main gastric heat Tianjin wound; Vomiting; Thirsty; Lung-heat QI rising in reverse order; Cough is more than.
Herba Pteridis Semipinnatae: base is former: be herb or the rhizome of Pteridaceae plant Herba Pteridis Semipinnatae.Nature and flavor: bitter; Pungent; Cool.Gui Jing: liver; Large intestine channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis; Removing toxic substances and promoting subsidence of swelling.Master has loose bowels; Dysentery; Jaundice; Conjunctival congestion and swelling pain; Toothache; Spit blood; Bleeding hemorrhoids; Traumatic hemorrhage; Traumatic injury; Skin pruritus; Venom.
Impatiens leptocaulon Hook.f.: base is former: be the root and rhizome of Balsaminaceae plant Herba Impatientis leptocauli flower.Nature and flavor: pungent; Bitter; Tepor.Function cures mainly: vital energy regualting and blood circulation-promoting pain relieving.Main air wet arthritis; Treating swelling and pain by traumatic injury.
Embodiment 1 treats the repellent antipruritic ointment of chilblain, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Solani Melongenae 8 parts, Radix radermacherae sinicae 6 parts, Pulicaria insignis Drumm. 4 parts, Herba Euonymi Bungeani 7 parts, Folium Malloti barbati 5 parts, Folium Hoveniae 3 parts, Radix Alternantherae philoxeroidis 6 parts, Medulla Tetrapanacis 4 parts, Herba Lysimachiae Lobelioidis 8 parts, Cortex Meliae 6 parts, 8 parts, Radix Actinidiae Erianthae leaf, Radix Chimonanthi praecocis 6 parts, Fructus Garciniae oblongifoliae 4 parts, Herba Pteridis Semipinnatae 7 parts, Impatiens leptocaulon Hook.f. 5 parts.The preparation method of the repellent antipruritic ointment of above-mentioned treatment chilblain is:
(1) get the clean oven dry of Radix radermacherae sinicae and Fructus Garciniae oblongifoliae, be placed in parch container, slow fire stir-fries 6 minutes, takes out and mixes with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add the soaking in rice vinegar of crude drug quality 1 times, and little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath 16 minutes, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 30 minutes, the Sal adding crude drug quality 0.2 times after taking-up is mixed thoroughly, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mix with step (1) (2) made crude drug, pulverized 70 mesh sieves, and made medicated powder;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix with step (3) made medicated powder, add the alcoholic solution of extracted crude drug quality 7 times, reflux, extract, twice, each extraction time is 40 minutes, filters, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, add vaseline and Adeps Sus domestica mixing, are heated to 50 DEG C and stir, furnishing paste, must treat the repellent antipruritic ointment of chilblain.
Embodiment 2 treats the repellent antipruritic ointment of chilblain, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Solani Melongenae 13 parts, Radix radermacherae sinicae 12 parts, Pulicaria insignis Drumm. 9 parts, Herba Euonymi Bungeani 11 parts, Folium Malloti barbati 10 parts, Folium Hoveniae 8 parts, Radix Alternantherae philoxeroidis 11 parts, Medulla Tetrapanacis 7 parts, Herba Lysimachiae Lobelioidis 11 parts, Cortex Meliae 13 parts, 12 parts, Radix Actinidiae Erianthae leaf, Radix Chimonanthi praecocis 10 parts, Fructus Garciniae oblongifoliae 11 parts, Herba Pteridis Semipinnatae 12 parts, Impatiens leptocaulon Hook.f. 11 parts.The preparation method of the repellent antipruritic ointment for the treatment of chilblain is:
(1) get the clean oven dry of Radix radermacherae sinicae and Fructus Garciniae oblongifoliae, be placed in parch container, slow fire stir-fries 12 minutes, takes out and mixes with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add the soaking in rice vinegar of crude drug quality 2 times, and little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath 28 minutes, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 50 minutes, the Sal adding crude drug quality 0.5 times after taking-up is mixed thoroughly, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mix with step (1) (2) made crude drug, pulverized 130 mesh sieves, and made medicated powder;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix with step (3) made medicated powder, add the alcoholic solution of extracted crude drug quality 9 times, reflux, extract, twice, each extraction time is 60 minutes, filters, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, add vaseline and Adeps Sus domestica mixing, are heated to 80 DEG C and stir, furnishing paste, must treat the repellent antipruritic ointment of chilblain.
Model case: xxx, female, 16 years old.Medical history: patient is middle school student, need go to school by bike during winter, finds that face and ear start swelling within the next few days, and local skin is rubescent, have caking, and pruritus is obvious, and that touches is ice-cold, and swelling pruritus after heated increases the weight of, and on inspection, is diagnosed as II degree chilblain.
Use the repellent antipruritic ointment of the present embodiment gained treatment chilblain, every day 2 times, first clean affected part with warm water, uniform application is in affected part again, use half an hour, swelling pruritus is eliminated substantially, adheres to that use is after one week, uncomfortable disease is all eliminated, skin recovers normal, continues use three days, and patient fully recovers, follow up a case by regular visits to 1 year, do not recur.
Embodiment 3 treats the repellent antipruritic ointment of chilblain, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Solani Melongenae 10 parts, Radix radermacherae sinicae 8 parts, Pulicaria insignis Drumm. 5 parts, Herba Euonymi Bungeani 8 parts, Folium Malloti barbati 6 parts, Folium Hoveniae 4 parts, Radix Alternantherae philoxeroidis 7 parts, Medulla Tetrapanacis 5 parts, Herba Lysimachiae Lobelioidis 9 parts, Cortex Meliae 8 parts, 9 parts, Radix Actinidiae Erianthae leaf, Radix Chimonanthi praecocis 7 parts, Fructus Garciniae oblongifoliae 6 parts, Herba Pteridis Semipinnatae 9 parts, Impatiens leptocaulon Hook.f. 7 parts.The preparation method of the repellent antipruritic ointment for the treatment of chilblain is:
(1) get the clean oven dry of Radix radermacherae sinicae and Fructus Garciniae oblongifoliae, be placed in parch container, slow fire stir-fries 8 minutes, takes out and mixes with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add the soaking in rice vinegar of crude drug quality 1 times, and little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath 20 minutes, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 35 minutes, the Sal adding crude drug quality 0.3 times after taking-up is mixed thoroughly, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mix with step (1) (2) made crude drug, pulverized 90 mesh sieves, and made medicated powder;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix with step (3) made medicated powder, add the alcoholic solution of extracted crude drug quality 7.5 times, reflux, extract, twice, each extraction time is 45 minutes, filters, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, add vaseline and Adeps Sus domestica mixing, are heated to 60 DEG C and stir, furnishing paste, must treat the repellent antipruritic ointment of chilblain.
Embodiment 4 treats the repellent antipruritic ointment of chilblain, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Solani Melongenae 11 parts, Radix radermacherae sinicae 10 parts, Pulicaria insignis Drumm. 8 parts, Herba Euonymi Bungeani 10 parts, Folium Malloti barbati 9 parts, Folium Hoveniae 7 parts, Radix Alternantherae philoxeroidis 10 parts, Medulla Tetrapanacis 6 parts, Herba Lysimachiae Lobelioidis 10 parts, Cortex Meliae 11 parts, 11 parts, Radix Actinidiae Erianthae leaf, Radix Chimonanthi praecocis 9 parts, Fructus Garciniae oblongifoliae 9 parts, Herba Pteridis Semipinnatae 10 parts, Impatiens leptocaulon Hook.f. 9 parts.The preparation method of the repellent antipruritic ointment for the treatment of chilblain is:
(1) get the clean oven dry of Radix radermacherae sinicae and Fructus Garciniae oblongifoliae, be placed in parch container, slow fire stir-fries 10 minutes, takes out and mixes with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add the soaking in rice vinegar of crude drug quality 2 times, and little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath 24 minutes, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 45 minutes, the Sal adding crude drug quality 0.4 times after taking-up is mixed thoroughly, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mix with step (1) (2) made crude drug, pulverized 110 mesh sieves, and made medicated powder;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix with step (3) made medicated powder, add the alcoholic solution of extracted crude drug quality 8.5 times, reflux, extract, twice, each extraction time is 55 minutes, filters, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, add vaseline and Adeps Sus domestica mixing, are heated to 70 DEG C and stir, furnishing paste, must treat the repellent antipruritic ointment of chilblain.
Model case: xxx, man, 48 years old.Medical history: patient works throughout the year outside, because cold weather adds warming not thorough, both hands and both feet all frost bittens, red swelling of the skin, pruritus, there is erythema, obscure boundary, time serious, there will be vesicle, ulcer, consciousness disappears, and once uses many Drug therapys to protect, and effect is very not remarkable.
The present embodiment gained is used to treat the repellent antipruritic ointment of chilblain through friend recommendation, every day 2 times, first clean affected part with warm water, then uniform application is in affected part, after patient uses one week, subsiding a swelling substantially in cold injury place, without uncomfortable diseases such as prurituss, adheres to that use is after 15 days, patient wound fully recovers, skin color recovers normal, follows up a case by regular visits to so far, without recurrence.
Embodiment 5 treats the repellent antipruritic ointment of chilblain, is prepared from (every part of 10g) primarily of following bulk drugs: Radix Solani Melongenae 10.5 parts, Radix radermacherae sinicae 9 parts, Pulicaria insignis Drumm. 6.5 parts, Herba Euonymi Bungeani 9 parts, Folium Malloti barbati 7.5 parts, Folium Hoveniae 5.5 parts, Radix Alternantherae philoxeroidis 8.5 parts, Medulla Tetrapanacis 5.5 parts, Herba Lysimachiae Lobelioidis 9.5 parts, Cortex Meliae 9.5 parts, 10 parts, Radix Actinidiae Erianthae leaf, Radix Chimonanthi praecocis 8 parts, Fructus Garciniae oblongifoliae 7.5 parts, Herba Pteridis Semipinnatae 9.5 parts, Impatiens leptocaulon Hook.f. 8 parts.The preparation method of the repellent antipruritic ointment for the treatment of chilblain is:
(1) get the clean oven dry of Radix radermacherae sinicae and Fructus Garciniae oblongifoliae, be placed in parch container, slow fire stir-fries 9 minutes, takes out and mixes with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add the soaking in rice vinegar of crude drug quality 1.5 times, and little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath 22 minutes, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 40 minutes, the Sal adding crude drug quality 0.35 times after taking-up is mixed thoroughly, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mix with step (1) (2) made crude drug, pulverized 100 mesh sieves, and made medicated powder;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix with step (3) made medicated powder, add the alcoholic solution of extracted crude drug quality 8 times, reflux, extract, twice, each extraction time is 50 minutes, filters, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, add vaseline and Adeps Sus domestica mixing, are heated to 65 DEG C and stir, furnishing paste, must treat the repellent antipruritic ointment of chilblain.
The clinical practice of the repellent antipruritic ointment (embodiment 5) of test example 1 gained treatment of the present invention chilblain:
Choose crowd: in March ,-2015 in November, 2014, according to medical case history, screen chilblain patient 282 example of accepting for medical treatment in four hospitals, age 10-65 year, 42.6 ± 1.8 years old mean age, the course of disease 1 month-4 years, male patient 143 example, female patient 139 example.All patients all meet the diagnostic criteria of " disease of tcm Standardization of diagnosis and curative effect " I degree, II degree, III degree locality chilblain, and patient accepts treatment voluntarily and observes, wherein I degree chilblain patient 54 example, II degree chilblain patient 136 example, III degree chilblain patient 92 example.
Before test, patient is divided into two groups at random, experimental group 180 example and matched group 102 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, one day twice, first clean affected part with warm water, then uniform application is in affected part, continuously treatment 15 days; Matched group uses other conventional medicines (spirit of Adeps Serpentis kibe ointment, chilblain, snake oil ointment etc.).Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: redness disappears, face healing of festering, and the symptoms such as pruritus twinge are all eliminated; (2) effective: red and swollen area reduces more than 70%, and the symptoms such as the face wound of festering significantly reduces, pruritus obviously alleviate; (3) invalid: after treatment, symptom is not improved or increases the weight of.Total effective rate=(cure+effectively)/total number of cases * 100%.
Clinical effectiveness: after the treatment of 15 days, the therapeutic outcome of two groups is as shown in table 1:
Table 1
The cure rate of experimental group is 93.3%, and total effective rate is 100%, and the cure rate of matched group is 76.5%, and total effective rate is 95.1%, is starkly lower than the therapeutic effect of experimental group, and illustrate that products obtained therefrom of the present invention is evident in efficacy, therapeutic effect is good.By observing the treatment time of two groups, experimental group Mean treatment duration is 6.5 days, and the Mean treatment duration of matched group is 12.5 days, and products obtained therefrom instant effect of the present invention is described, effective.
The Chinese medicine used in the present invention, multiple medical material synergism, Radix Solani Melongenae clearing away heat to stop bleeding, Radix radermacherae sinicae dissipating blood stasis for subsidence of swelling, Pulicaria insignis Drumm. removing pathogenic heat from blood and toxic substance from the body, Herba Euonymi Bungeani promoting blood circulation to remove obstruction in the collateral, Folium Malloti barbati dampness removing to stop itchin, Folium Hoveniae, Radix Actinidiae Erianthae leaf heat-clearing and toxic substances removing, Radix Alternantherae philoxeroidis, Medulla Tetrapanacis clearing away heat and cooling blood, Herba Lysimachiae Lobelioidis hemostasia and promoting granulation, Cortex Meliae parasite killing treats tinea, Radix Chimonanthi praecocis vital energy regualting and blood circulation-promoting, Fructus Garciniae oblongifoliae's clearing away heat and promoting production of body fluid, Herba Pteridis Semipinnatae removing toxic substances and promoting subsidence of swelling, Impatiens leptocaulon Hook.f. vital energy regualting and blood circulation-promoting, plays effect of dissipating blood stasis for subsidence of swelling, promoting flow of QI and blood altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the repellent antipruritic ointment of chilblain, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Solani Melongenae 8-13, Radix radermacherae sinicae 6-12, Pulicaria insignis Drumm. 4-9, Herba Euonymi Bungeani 7-11, Folium Malloti barbati 5-10, Folium Hoveniae 3-8, Radix Alternantherae philoxeroidis 6-11, Medulla Tetrapanacis 4-7, Herba Lysimachiae Lobelioidis 8-11, Cortex Meliae 6-13, Radix Actinidiae Erianthae leaf 8-12, Radix Chimonanthi praecocis 6-10, Fructus Garciniae oblongifoliae 4-11, Herba Pteridis Semipinnatae 7-12, Impatiens leptocaulon Hook.f. 5-11.
2. the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 1, is characterized in that, Radix Solani Melongenae 10-11, Radix radermacherae sinicae 8-10, Pulicaria insignis Drumm. 5-8, Herba Euonymi Bungeani 8-10, Folium Malloti barbati 6-9, Folium Hoveniae 4-7, Radix Alternantherae philoxeroidis 7-10, Medulla Tetrapanacis 5-6, Herba Lysimachiae Lobelioidis 9-10, Cortex Meliae 8-11, Radix Actinidiae Erianthae leaf 9-11, Radix Chimonanthi praecocis 7-9, Fructus Garciniae oblongifoliae 6-9, Herba Pteridis Semipinnatae 9-10, Impatiens leptocaulon Hook.f. 7-9.
3. the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 1, is characterized in that, Radix Solani Melongenae 10.5, Radix radermacherae sinicae 9, Pulicaria insignis Drumm. 6.5, Herba Euonymi Bungeani 9, Folium Malloti barbati 7.5, Folium Hoveniae 5.5, Radix Alternantherae philoxeroidis 8.5, Medulla Tetrapanacis 5.5, Herba Lysimachiae Lobelioidis 9.5, Cortex Meliae 9.5, Radix Actinidiae Erianthae leaf 10, Radix Chimonanthi praecocis 8, Fructus Garciniae oblongifoliae 7.5, Herba Pteridis Semipinnatae 9.5, Impatiens leptocaulon Hook.f. 8.
4. the preparation method of the repellent antipruritic ointment of the treatment chilblain as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Radix radermacherae sinicae and Fructus Garciniae oblongifoliae to clean and dry, be placed in parch container, slow fire stir-fry 6-12 minute (preferred: slow fire stir-fries 8-10 minute; Be more preferably: slow fire stir-fries 9 minutes), take out and mix with Pulicaria insignis Drumm., Folium Malloti barbati, Folium Hoveniae and Radix Actinidiae Erianthae leaf, add soaking in rice vinegar, little fire boils and is sucked to rice vinegar, takes out;
(2) get Radix Solani Melongenae, Radix Chimonanthi praecocis and Impatiens leptocaulon Hook.f. removing impurity, add in lime water and infiltrate 1 minute, take out, drench and mix thoroughly into refined honey water, then add washing water of rice Steam by water bath, take out slow fire and dry;
(3) Herba Euonymi Bungeani and Cortex Meliae are cleaned shredding, add yellow wine and soak 30-50 minute (preferably: soak 35-45 minute; Be more preferably: soak 40 minutes), mix thoroughly with Sal after taking-up, be placed in frying pan, slow fire is fried and is turned yellow to crude drug surface, takes out, mixes, pulverize and sieve, make medicated powder with step (1) (2) made crude drug;
(4) Radix Alternantherae philoxeroidis, Medulla Tetrapanacis, Herba Lysimachiae Lobelioidis and Herba Pteridis Semipinnatae are cleaned chopping, mix, add alcoholic solution, reflux, extract, twice with step (3) made medicated powder, it is (preferred: extraction time is 45-55 minute at every turn that each extraction time is 40-60 minute; Be more preferably: each extraction time is 50 minutes), filter, merge twice gained filtrate, and reclaim ethanol;
(5) spray drying step (4) gains, make medicated powder, and add vaseline and Adeps Sus domestica mixing, heated and stirred is even, and furnishing paste, must treat the repellent antipruritic ointment of chilblain.
5. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, is characterized in that, step (1) is the 1-2 of crude drug quality doubly (preferred: to be 1.5 times of crude drug quality with rice vinegar amount) with rice vinegar amount.
6. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, is characterized in that, step (2) Steam by water bath 16-28 minute (preferred: Steam by water bath 20-24 minute; Be more preferably: Steam by water bath 22 minutes).
7. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, is characterized in that, it is that the 0.2-0.5 of crude drug quality is doubly (preferred: to add 0.3-0.4 times that salinity is crude drug quality that step (3) adds salinity; Be more preferably: add 0.35 times that salinity is crude drug quality).
8. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, it is characterized in that, it is (preferred: to pulverize 90-110 mesh sieve that step (3) pulverized 70-130 mesh sieve; Be more preferably: pulverized 100 mesh sieves).
9. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, it is characterized in that, the consumption that step (4) adds alcoholic solution by extraction crude drug quality 7-9 doubly (preferred: the consumption adding alcoholic solution by 7.5-8.5 times of extractions crude drug quality; Be more preferably: the consumption adding alcoholic solution by 8 times of extraction crude drug quality).
10. the preparation method of the repellent antipruritic ointment for the treatment of chilblain as claimed in claim 4, is characterized in that, step (5) heating-up temperature be 50-80 DEG C (preferred: heating-up temperature is 60-70 DEG C; Be more preferably: heating-up temperature is 65 DEG C).
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110063940A (en) * | 2018-01-21 | 2019-07-30 | 吴千帆 | Bedsore healing powder |
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| CN103316257A (en) * | 2013-06-20 | 2013-09-25 | 白会娟 | Chinese herbal medicine for treating chilblain |
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| CN103316257A (en) * | 2013-06-20 | 2013-09-25 | 白会娟 | Chinese herbal medicine for treating chilblain |
| CN105055685A (en) * | 2015-08-13 | 2015-11-18 | 李臣君 | Ointment for treating chilblain and preparation method of ointment |
| CN105106660A (en) * | 2015-10-08 | 2015-12-02 | 皖南医学院 | Chilblain ointment capable of protecting skin and smoothening scars as well as preparation method of ointment |
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