CN116942745B - Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof Download PDFInfo
- Publication number
- CN116942745B CN116942745B CN202311215762.9A CN202311215762A CN116942745B CN 116942745 B CN116942745 B CN 116942745B CN 202311215762 A CN202311215762 A CN 202311215762A CN 116942745 B CN116942745 B CN 116942745B
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- root
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 99
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 208000007893 Salpingitis Diseases 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title abstract description 25
- 235000013399 edible fruits Nutrition 0.000 claims description 56
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 claims description 52
- 244000025254 Cannabis sativa Species 0.000 claims description 30
- 239000000463 material Substances 0.000 claims description 29
- 241000219318 Amaranthus Species 0.000 claims description 26
- 241000830535 Ligustrum lucidum Species 0.000 claims description 26
- 241000382455 Angelica sinensis Species 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 241000208368 Euonymus alatus Species 0.000 claims description 18
- 241000131505 Gloriosa Species 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 13
- 241000357625 Campanumoea Species 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 7
- 238000005520 cutting process Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000000643 oven drying Methods 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- -1 decoction Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 22
- 210000004185 liver Anatomy 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 15
- 210000000952 spleen Anatomy 0.000 abstract description 12
- 210000003734 kidney Anatomy 0.000 abstract description 11
- 238000005728 strengthening Methods 0.000 abstract description 7
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 235000019629 palatability Nutrition 0.000 abstract description 2
- 235000013601 eggs Nutrition 0.000 description 30
- 230000000052 comparative effect Effects 0.000 description 25
- 239000008280 blood Substances 0.000 description 16
- 210000004369 blood Anatomy 0.000 description 16
- 235000019640 taste Nutrition 0.000 description 13
- 241000287828 Gallus gallus Species 0.000 description 12
- 235000013330 chicken meat Nutrition 0.000 description 12
- 230000010415 tropism Effects 0.000 description 12
- 206010042674 Swelling Diseases 0.000 description 11
- 230000008961 swelling Effects 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 8
- 241000208367 Euonymus Species 0.000 description 7
- 208000004880 Polyuria Diseases 0.000 description 7
- 230000035619 diuresis Effects 0.000 description 7
- 210000003101 oviduct Anatomy 0.000 description 6
- 206010007247 Carbuncle Diseases 0.000 description 5
- 210000003555 cloaca Anatomy 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000003746 feather Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 3
- 241000112528 Ligusticum striatum Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 229960003022 amoxicillin Drugs 0.000 description 3
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 210000003278 egg shell Anatomy 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000012795 verification Methods 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 241001071795 Gentiana Species 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 240000004980 Rheum officinale Species 0.000 description 2
- 235000008081 Rheum officinale Nutrition 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000003325 follicular Effects 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 230000006996 mental state Effects 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 241000125175 Angelica Species 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000296609 Celastrus angulatus Species 0.000 description 1
- 206010008469 Chest discomfort Diseases 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 241001256368 Clematis chinensis Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010063057 Cystitis noninfective Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241001160641 Euonymus grandiflorus Species 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 241000421432 Glochidion Species 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000238367 Mya arenaria Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 208000033952 Paralysis flaccid Diseases 0.000 description 1
- 244000064622 Physalis edulis Species 0.000 description 1
- 244000274050 Platycodon grandiflorum Species 0.000 description 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000607683 Salmonella enterica subsp. enterica serovar Pullorum Species 0.000 description 1
- 240000009022 Smilax rotundifolia Species 0.000 description 1
- 235000003205 Smilax rotundifolia Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010049514 Traumatic fracture Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 201000005661 acute cystitis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 201000003139 chronic cystitis Diseases 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 201000003146 cystitis Diseases 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 208000028331 flaccid paralysis Diseases 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000005963 oophoritis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000017448 oviposition Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating salpingitis of laying hens and a preparation method thereof. The invention is a pure traditional Chinese medicine preparation, has obvious treatment effect, reasonable formula, synergistic effect among the raw material components, no medicine residue, no drug resistance, no palatability problem, simple preparation process, low cost and the like. The traditional Chinese medicine composition has the effects of detumescence, clearing damp, clearing heat and detoxicating, soothing liver, strengthening spleen, nourishing yin, tonifying kidney and the like, and can effectively treat salpingitis of laying hens, quickly restore laying rate of the laying hens, improve egg quality and reduce poor egg yield.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating salpingitis of laying hens and a preparation method thereof.
Background
Salpingitis of laying hens is one of the frequently occurring diseases in the chicken raising industry, and is frequently generated in the peak period of laying hen. Laying hen salpingitis is clinically characterized by hemorrhagic salpingitis, abnormal egg production, and often discharge of yellow and white purulent secretions around cloaca, etc., and often causes peritonitis and oophoritis. The pathogenesis of salpingitis of laying hens is many and complex, and serious economic loss is caused for the chicken raising industry.
The main causes of salpingitis of laying hens are as follows: the sanitary condition of the raising chicken house is too bad, and the cloaca is polluted by bacteria such as escherichia coli, salmonella pullorum, paratyphoid bacillus and the like and invades the oviduct; overmuch animal feed is fed, the egg is produced too much or double-yolk eggs are produced, and sometimes the eggshells are broken in the oviducts to damage the oviducts; the feed lacks trace elements such as vitamin A, D, E; other factors; such as being stressed, misused with the drug, etc. When the oviduct is inflamed, the laying rate and the quality of eggs are firstly affected, the laying rate is reduced (10% -30%) and the number of inferior eggs is increased, secondary infection of other organs, even systemic infection, and even more serious, the death number of the chickens is increased. The sick chicken is mainly characterized by uneasiness, difficulty in lying down, and the laid eggs and eggshells often have blood stains, and the feathers around cloaca are polluted. The sectioning and inspection of the sick chicken can be seen; the abdominal cavity of the sick chicken has obvious lesions, the wall of the oviduct becomes thin, the follicular part shows swelling, water filling, bleeding, necrosis and mucosa adhesion, the follicular shrinkage is irregular, and broken yolk liquid and the like are arranged in the abdominal cavity.
According to the basic theory of Chinese veterinarian, the laying hen is difficult to clear due to exogenous pathogenic factors, excessive strain of egg production and the like, so that five endogenous pathogenic factors, damp-heat cementation and blood stasis are difficult to remove, qi and blood circulation are unsmooth, viscera function is disordered, and the damage can not be cleared, and new growth is caused, so that damp stagnation, blood stasis, qi stagnation, cold coagulation and deficiency of vital qi occur, so that the disease of salpingitis is aggravated due to the invasion of exogenous pathogenic factors such as dampness and the like. The recipe takes the effects of detumescence, clearing away heat and toxic material, soothing liver, strengthening spleen, nourishing yin, tonifying kidney and the like as the direction.
At present, most of the laying hen salpingitis diseases are treated by using antibiotic medicines, firstly, the antibiotics are easy to generate drug resistance, and the treatment is ineffective or easy to recur; secondly, a large amount of antibiotics can generate side effects and drug residues, and harmful residues can directly influence human health. The dialectical treatment of the traditional Chinese medicine has better treatment advantage, and the Chinese herbal medicine preparation has the characteristics of nature, no public hazard, green environmental protection, no drug resistance and no residue. The action plan of reducing resistance, forbidding resistance and product no-resistance of the breeding industry is accelerated. The application of traditional Chinese medicine in the breeding industry is indispensable, and the traditional Chinese medicine preparation is also a trend to replace antibiotic products in the breeding industry.
Disclosure of Invention
In order to solve the defects of the prior art and meet clinical requirements, the invention provides the traditional Chinese medicine composition for treating the salpingitis of the laying hens, which has the advantages of obvious treatment effect, reasonable formula, synergistic effect among the raw material components, no medicine residue, no medicine resistance and no palatability, simple preparation process and low cost, and the preparation method thereof.
In order to achieve the above purpose, the technical scheme provided by the invention is as follows:
the Chinese medicinal composition is prepared from, by weight, 20-30 parts of Chinese medicinal herbs, 10-20 parts of peltate yam herb, 8-12 parts of amaranthus auriculatus, 6-12 parts of large fruit euonymus alatus, 20-30 parts of azulene root, 10-20 parts of gloriope gloriosa, 6-12 parts of Chinese angelica, 6-12 parts of glossy privet fruit and 10-20 parts of camphol.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials, by weight, 23-27 parts of selvedge, 12-18 parts of peltate yam herb, 9-11 parts of amaranthus auriculatus, 8-10 parts of euonymus alatus, 23-27 parts of azulene root, 12-18 parts of abacus root, 8-10 parts of Chinese angelica, 8-10 parts of glossy privet fruit and 12-18 parts of campanumoea.
More preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight, 20 parts of large tile, 20 parts of stinky tree, 10 parts of clematis chinensis, 10 parts of white flowers, 10 parts of glossy privet roots, 8 parts of green tangerine peel, 6 parts of liquorice, 12 parts of platycodon grandiflorum, 8 parts of lily and 8 parts of bighead atractylodes rhizome.
More preferably, the traditional Chinese medicine composition is characterized in that: the Chinese medicinal composition is granule, oral liquid, decoction, powder, pill or tablet.
More preferably, the traditional Chinese medicine composition is in the form of granules.
The preparation for preparing the traditional Chinese medicine composition comprises the following preparation methods:
firstly, weighing the raw medicinal materials according to the parts by weight: 20-30 parts of well grass, 10-20 parts of shield fruit grass, 8-12 parts of amaranthus auriculata, 6-12 parts of large fruit euonymus alatus, 20-30 parts of azulene root, 10-20 parts of gloriosa albo-marginata root, 6-12 parts of Chinese angelica, 6-12 parts of glossy privet fruit and 10-20 parts of campanumaea acutifera; cleaning, oven drying, cutting, and mixing;
secondly, adding water which is 8-10 times of the total weight of all the medicinal materials, and soaking the sieved raw medicinal materials in the first step for 0.5-1h; then decocting with slow fire for 1.5h after boiling;
thirdly, filtering the traditional Chinese medicine in the second step, and adding water which is 7-9 times of the total weight of the medicinal materials into filter residues for decoction for 1h;
fourth, filtering the traditional Chinese medicine in the third step, and adding water which is 6-8 times of the total weight of the medicinal materials for decoction for 1h;
fifthly, merging the three decocted liquid medicines, standing for 24 hours, concentrating under reduced pressure until the relative density is 1.12-1.16, and cooling for standby;
and sixthly, slowly adding 70% ethanol with the amount of 2-2.5 times of the weight of the liquid medicine into the traditional Chinese medicine fluid extract obtained in the fifth step, standing for 24-48h, uniformly stirring, hermetically refrigerating for 24-48h, filtering, recovering the ethanol of the filtrate, and concentrating to the relative density of 1.33-1.36.
Seventh, the traditional Chinese medicine fluid extract obtained in the sixth step is spray-dried, granulated, sterilized and sub-packaged to obtain the traditional Chinese medicine compound preparation.
The invention also provides application of the traditional Chinese medicine composition in treating salpingitis of laying hens.
The medicinal properties and effects of the medicinal materials in the traditional Chinese medicine composition are as follows:
radix seu herba Physalis Pubescentis; taste: bitter; and (5) cooling. Channel tropism: a core; the large intestine channel. Clear away heat and toxic materials, and relieve swelling. Can be used for treating carbuncle, furuncle, bacillary dysentery, and enteritis.
Grass on the well side; taste: octyl; slightly bitter; and (5) cooling. Channel tropism: liver; large intestine; the bladder meridian. Clearing heat and promoting diuresis; promoting blood circulation and removing swelling. Primary diarrhea; diarrhea; edema; hepatitis; cholecystitis; throat obstruction; urinary system infection; carbuncle, swelling and sore; rheumatalgia; swelling and pain from injuries from falls.
Inverted zaolone; taste: octyl; bitter; and (5) cooling. Channel tropism: a lung; the liver meridian. Pain relieving, antiinflammatory, menstruation regulating. It is mainly used for treating furuncle, sore, and menoxenia.
azulene root; taste: sweet; flat. Channel tropism: liver; spleen meridian. Clear away damp-heat and detumescence toxin. It is mainly used for treating jaundice, damp arthralgia, heat stranguria, dysentery, swelling toxin, scrofula, etc.
Amaranthus auriculatus (L.) Spreng; taste: sweet in taste; light; the sex is flat. Channel tropism: spleen invigorating; the bladder meridian. Invigorating spleen and promoting diuresis; promoting qi circulation and removing blood stasis. Anorexia due to spleen deficiency; chest fullness and stuffiness; acute and chronic cystitis; women's leukorrhagia; traumatic injury, stasis and swelling and pain.
Celastrus angulatus; taste: sweet; slightly bitter; flat. Channel tropism: liver; spleen; kidney meridian. Kidney-tonifying and waist-strengthening; remove blood stasis and promote diuresis. Lumbago due to kidney deficiency; restlessness of fetal movement; chronic nephritis; lochia after childbirth is not complete; traumatic fracture; rheumatalgia; and (5) taking off.
Root of glochidion; taste: bitter and flat. Channel tropism: liver; the large intestine channel. Clear heat and promote diuresis, activate blood and detoxify. It is indicated for dysentery, malaria, jaundice, turbid urine, rheumatalgia, metrorrhagia, leukorrhagia, carbuncle, scrofula, etc.
Chinese angelica root; sex taste: sweet, pungent and warm. Channel tropism: it enters liver, heart and spleen meridians. Replenishing blood, regulating menstruation, relieving pain, moistening dryness and smoothing intestine. Treating menoxenia, amenorrhea, abdominal pain, abdominal mass, metrorrhagia; headache due to blood deficiency, dizziness, flaccid paralysis; difficulty in treating constipation, and severe red dysentery; carbuncles, sores, and the like.
Fructus Ligustri Lucidi; taste: bitter, sweet and flat. Channel tropism: liver; kidney meridian. Nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating soreness of waist and knees, clearing heat and improving eyesight.
The invention has the beneficial effects that: in the recipe, the selvedge and the azulene root are taken as monarch drugs, and the two drugs together have the effects of detumescence and clearing damp and heat. The campanumaea pilosula, the peltate yam and the root of the glabrous greenbrier rhizome are taken as ministerial drugs, and the three drugs act together to play roles of clearing heat, promoting diuresis, activating blood, removing toxicity, diminishing inflammation, relieving pain, and enhancing the detumescence and dampness removal of the monarch drug. The large fruit euonymus has the effects of tonifying kidney, strengthening waist, removing blood stasis and promoting diuresis; the amaranthus auriculatus can invigorate spleen, promote diuresis, promote qi circulation and remove blood stasis; dang Gui can enrich and harmonize blood, regulate menstruation and relieve pain, moisten dryness and smooth intestines; the glossy privet fruit can nourish liver and kidney, clear heat and improve eyesight, and the large fruit euonymus alatus, the amaranthus auriculata, the Chinese angelica and the glossy privet fruit are used as adjuvant drugs together to achieve the effects of tonifying liver and spleen, nourishing yin and tonifying kidney. The Chinese medicinal composition is prepared by reasonable compatibility according to the dialectical treatment principle of a Chinese veterinarian, fully plays the roles of the medicaments, combines the medicaments to synergistically enhance the efficacy, has the effects of detumescence, dampness elimination, heat clearing, detoxification, liver benefiting, spleen strengthening, yin nourishing, kidney tonifying and the like, and has remarkable effects on treating salpingitis of laying hens.
Drawings
Fig. 1: test result diagrams, wherein A1, A2 and A3 are inferior eggs produced by the test group layer after molding in the test 1; b1, B2 and B3 are respectively cloaca parts of the test group layer after molding in the test 1; c1, C2 and C3 are the sections of test groups 6, 7 and blank groups of laying hens in test 1 according to the invention, respectively.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described below with reference to specific embodiments, but it should not be construed that the scope of the present invention is limited to only the following embodiments.
Example 1
A traditional Chinese medicine composition for treating salpingitis of laying hens is prepared from the following raw materials in parts by weight: 28 parts of well grass, 13 parts of shield fruit grass, 9 parts of amaranthus auriculata, 10 parts of large fruit euonymus, 20 parts of azulene root, 12 parts of abacus root, 8 parts of Chinese angelica, 8 parts of glossy privet fruit and 15 parts of campanumoea.
The traditional Chinese medicine composition for treating salpingitis of laying hens is prepared according to the following steps:
firstly, weighing the raw materials in parts by weight: 28 parts of well grass, 13 parts of peltate yam herb, 9 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 20 parts of azulene root, 12 parts of abacus root, 8 parts of Chinese angelica, 8 parts of glossy privet fruit and 15 parts of campanumaea pilosula; cleaning, oven drying, cutting, and mixing;
adding water 10 times of the total weight of all the medicinal materials, and soaking the sieved medicinal materials for 1h; then decocting with slow fire for 1.5h after boiling;
thirdly, filtering the traditional Chinese medicine in the second step, and adding water which is 9 times of the total weight of the medicinal materials into filter residues for decoction for 1h;
fourth, filtering the traditional Chinese medicine in the third step, and adding water which is 8 times of the total weight of the medicinal materials to decoct for 1h;
fifthly, merging the three decocted liquid medicines, standing for 24 hours, concentrating under reduced pressure until the relative density is 1.12-1.16, and cooling for standby;
and sixthly, slowly adding 70% ethanol by weight which is 2.5 times of the weight of the liquid medicine into the traditional Chinese medicine fluid extract obtained in the fifth step, standing for 24 hours, uniformly stirring, hermetically refrigerating for 24 hours, filtering, recovering the ethanol of the filtrate, and concentrating to the relative density of 1.33-1.36.
Seventh, the traditional Chinese medicine fluid extract obtained in the sixth step is spray-dried, prepared into granules, sterilized and packaged to obtain the traditional Chinese medicine compound preparation.
Example 2
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of well grass, 11 parts of peltate yam, 8 parts of amaranthus auriculatus, 7 parts of large fruit euonymus, 30 parts of azulene root, 10 parts of gloriosa root, 7 parts of angelica sinensis, 7 parts of glossy privet fruit and 10 parts of campanumoea.
The preparation method is described in example 1.
Example 3
This example differs from example 1 in the raw materials (in parts by weight): 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumoea.
The preparation method is described in example 1.
Example 4
This example differs from example 1 in the raw materials (in parts by weight): 30 parts of well grass, 15 parts of peltate yam, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus, 30 parts of azulene root, 15 parts of gloriosa, 8 parts of angelica sinensis, 7 parts of glossy privet fruit and 15 parts of campanumoea.
The preparation method is described in example 1.
Example 5
This example differs from example 1 in the raw materials (in parts by weight): 20 parts of well grass, 12 parts of shield fruit grass, 10 parts of amaranthus auriculata, 10 parts of large fruit euonymus, 20 parts of azulene root, 12 parts of abacus root, 7 parts of Chinese angelica, 7 parts of glossy privet fruit and 10 parts of camphol.
The preparation method is described in example 1.
Example 6
This example differs from example 1 in the raw materials (in parts by weight): 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumoea.
The traditional Chinese medicine composition for treating salpingitis of laying hens is prepared according to the following steps:
firstly, weighing the raw materials in parts by weight: 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumaea pilosula; cleaning, oven drying, cutting, and mixing;
adding water 10 times of the total weight of all the medicinal materials, and soaking the sieved medicinal materials for 1h; then decocting with slow fire for 1.5h after boiling;
thirdly, filtering the traditional Chinese medicine in the second step, and adding water which is 9 times of the total weight of the medicinal materials into filter residues for decoction for 1h;
fourth, filtering the traditional Chinese medicine in the third step, and adding water which is 8 times of the total weight of the medicinal materials to decoct for 1h;
fifthly, merging the three decocted liquid medicines, standing for 24 hours, concentrating under reduced pressure until the relative density is 1.12-1.16, and cooling for standby;
sixthly, slowly adding 70% ethanol in the Chinese medicinal fluid extract in the fifth step, wherein the amount of the ethanol is 2.5 times of the weight of the liquid medicine, standing for 24 hours, uniformly stirring, hermetically refrigerating for 24 hours, filtering, and recovering the ethanol from the filtrate to obtain refined liquid; then adding water for dissolving, heating to completely dissolve, standing and refrigerating for more than 12 hours, filtering, concentrating the liquid medicine until the crude drug is 1g/mL, packaging, and sterilizing to obtain the oral liquid.
Example 7
This example differs from example 1 in the raw materials (in parts by weight): 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumoea.
The traditional Chinese medicine composition for treating salpingitis of laying hens is prepared according to the following steps:
firstly, weighing the raw materials in parts by weight: 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumaea pilosula; cleaning, drying and cutting into sections;
and secondly, crushing the raw materials with the weight, which are weighed in the first step, sieving the crushed raw materials with a 80-mesh sieve, and uniformly mixing the crushed raw materials according to a proportion to prepare powder.
Comparative example 1
This example is a comparative example of a traditional Chinese medicine prescription for treating salpingitis of laying hens, and azulene roots are not added, and the difference between this comparative example and example 1 is that the raw materials (in parts by weight): 25 parts of well grass, 15 parts of shield fruit grass, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 15 parts of abacus root, 10 parts of Chinese angelica, 10 parts of glossy privet fruit and 15 parts of campholly
The preparation method is described in example 1.
Comparative example 2
This example is another comparative example of a traditional Chinese medicine formulation for treating salpingitis of laying hens, and well grass will not be added, and the difference between this comparative example and example 1 is that the raw materials (in parts by weight):
15 parts of peltate yam, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of Chinese angelica, 10 parts of glossy privet fruit and 15 parts of campholone.
The preparation method is described in example 1.
Comparative example 3
The present example is another comparative example of a traditional Chinese medicine prescription for treating salpingitis of laying hens, in which well-side grass is replaced by gentian, and the difference between the present comparative example and example 1 is that the raw materials (in parts by weight): 25 parts of gentian, 15 parts of peltate yam, 10 parts of amaranth, 10 parts of euonymus grandiflorus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumoea.
Radix Gentianae; taste: bitter; cold. Channel tropism: liver meridian; the gallbladder meridian. Clear heat and dry dampness, purge liver and gall fire. Can be used for treating jaundice due to damp-heat, swelling and itching of yin, leukorrhagia, strengthening middle-jiao, eczema and itching, conjunctival congestion, deafness, hypochondriac pain, bitter taste, and convulsion. The preparation method is described in example 1.
Comparative example 4
The present example is another comparative example of a traditional Chinese medicine prescription for treating salpingitis of laying hens, in which the root of gloriosa is replaced by Ligusticum wallichii, and the difference between the present comparative example and example 1 is that the raw materials (in parts by weight): 15 parts of well grass, 15 parts of peltate yam, 15 parts of amaranthus auriculatus, 15 parts of large fruit euonymus, 15 parts of azulene root, 15 parts of ligusticum wallichii, 15 parts of Chinese angelica, 15 parts of glossy privet fruit and 15 parts of campholly.
Ligusticum wallichii; taste: temperature is high; pungent. Channel tropism: liver, gallbladder and pericardium channels. Promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Can be used for soothing nerves, relieving headache, abdominal pain, stabbing pain in chest and hypochondrium, swelling and pain from traumatic injury, headache, and rheumatalgia.
The preparation method is described in example 1.
Comparative example 5
This example is another comparative example of a traditional Chinese medicine formulation for treating salpingitis of laying hens, and is different from example 1 in that the raw materials (in parts by weight) are: 25 parts of well grass, 15 parts of peltate yam, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriope gloriosa root and 15 parts of campanumaea acutangula
Comparative example 6
This example is another comparative example of a traditional Chinese medicine formulation for treating salpingitis of laying hens, which is different from example 1 in the raw materials (in parts by weight) without adding gloriosa, angelica and glossy privet fruit: 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root and 15 parts of campholone.
The preparation method is described in example 1.
Comparative example 7
This example is another comparative example of a traditional Chinese medicine prescription for treating salpingitis of laying hens, in which azulene root is replaced with rheum officinale, and the difference between this comparative example and example 1 is that the raw materials (in parts by weight): 28 parts of well grass, 13 parts of peltate yam herb, 9 parts of amaranthus auriculatus, 10 parts of large fruit euonymus, 20 parts of rheum officinale, 12 parts of radix polygoni multiflori, 8 parts of Chinese angelica, 8 parts of glossy privet fruit and 15 parts of campholly root.
Radix et rhizoma Rhei; taste: bitter and cold. Channel tropism: stomach, liver and large intestine channels. Purging excessive heat, removing accumulation and stagnation, and promoting blood stasis. The main indications are: constipation due to excessive heat, food stagnation, abdominal pain, acute appendicitis, acute infectious hepatitis, amenorrhea due to blood stasis, carbuncle, swelling and ulcer.
The preparation method is described in example 1.
Test example 1 the effect verification of the Chinese medicinal composition of the invention on salpingitis of artificially infected laying hens
1. Test materials
1.1 test animals
The 27-week-old sea orchid brown layer chicken is purchased from Beijing Fuhao experimental animal cultivation center.
1.2 Test reagent
Phenol (formulated as a 15% phenol solution) was purchased from Shanghai Meilin Biochemical technologies Co.
10% amoxicillin soluble powder, purchased from North China pharmaceutical group animal health products Limited company.
2. Test method
2.1 Test group and administration
2.2 Test method
Except for the blank control group, the equivalent normal saline is injected, and the other groups of laying hens are injected to the position of 2-3cm of the oviduct according to 1mL of phenol reagent per feather.
Starting from the 1 st day of molding, the blank control group is not dosed and is fed normally; the other groups are continuously administered for 7 days according to the medicine mixture or mixed water, wherein the western medicine control group is amoxicillin; test groups 1-7 were dosed as examples 1-7, respectively, in the present invention; comparative groups 1-7 were dosed as comparative examples 1-7, respectively, in the present invention. The method comprises the steps of feeding test laying hens normally for 2 times a day, observing the egg yield and abnormal egg conditions of the test laying hens, wherein inferior eggs comprise blood spot eggs, fecal eggs, soft preserved eggs, sand preserved eggs, broken eggs and the like, and observing and recording the mental condition, appetite, morbidity and cutting and examining of dead laying hens.
Test treatment criteria; the cure is that the mental state and feeding of the sick chickens are recovered to be normal, the egg yield is close to that of a blank control group, and the inferior egg yield is reduced or not. The effective method is that the appetite and the feeding of the sick chickens are recovered to be normal, the egg yield is improved, and the inferior egg yield is gradually reduced. The invalidation means that after the administration, the mental state and the feeding condition of the sick chickens are not recovered, the egg yield is not improved, and the inferior egg yield is not reduced.
3. Test results
Table 1 tests of the Effect of each group of drugs on salpingitis of artificially infected laying hens
As can be seen from the test data in Table 1, the cure effective rates of the test groups 1 to 7 are higher than those of the western medicine control group; the laying rate of the test group 3 (88.1%) is higher than that of the western medicine control group (86.9%) and other test groups; inferior egg rates of test group 3 (12.2%), test group 6 (12.2%) and test group 4 (13.1%) were lower than western control group (13.7%); test groups 1-7 did not die during the test period, while the control groups had different degrees of layer death during the test period, the anatomical test results were shown as C1 and C2 in FIG. 1, and C3 in FIG. 1 was a blank control group layer profile. The test results show that the traditional Chinese medicine composition prepared by the invention can effectively treat salpingitis of laying hens, improve laying rate, improve egg quality and reduce death rate of the laying hens.
Test example 2 the effect verification of the Chinese medicinal composition of the invention in clinic for treating salpingitis of laying hens
The clinical test chicken flock is 6000 feathers of 350-day-old laying hens and is cultivated by a certain raiser in the Pinggu area of Beijing city. The laying hen of the house is listless, inappetence, camping, belly swelling, fecal matter attached to feathers around cloaca, the egg yield of the whole house is continuously reduced, the egg shells are provided with blood marks, soft shell eggs, sand shell eggs and broken shell eggs, and the laying hen of the house is judged to have salpingitis. The average laying hen of the house is divided into 6 groups of 1000 laying hens, and the blank control group is normally fed without drug administration; the western medicine control group is given with amoxicillin 0.3% mixed material and continuously administered for 7 days; the medicines prepared in example 3 and example 6 of the present invention were used in test group 1 and test group 2, respectively, and the medicines prepared in comparative example 1 and comparative example 6 of the present invention were used in comparative group 1 and comparative group 2, respectively, and were continuously administered for 7 days in accordance with a 0.4% mix.
TABLE 2 test of the clinical Effect of various groups of drugs on salpingitis in laying hens
As can be seen from the test data in table 2, the egg laying rates of the test group 1 and the test group 2 are higher than those of the western medicine control group and the blank control group; the inferior egg rate and the death rate of the test group 1 and the test group 2 are lower than those of the western medicine control group, the contrast group and the blank control group.
Proved by clinical verification results, the traditional Chinese medicine composition prepared by the invention can effectively improve the laying rate, improve the egg quality and reduce the death rate of the laying hens, and the traditional Chinese medicine composition prepared by the invention can effectively treat salpingitis diseases of the laying hens.
According to the traditional Chinese medicine composition disclosed by the invention, the compatibility of medicines is reasonable, the pharmacological effects of the medicines are fully exerted according to the syndrome differentiation and treatment principle of a traditional Chinese medicine veterinarian, and the combination of the medicines can achieve the effects of synergistic effect, and the traditional Chinese medicine composition has the effects of detumescence, dampness elimination, heat clearing, detoxification, liver soothing, spleen strengthening, yin nourishing, kidney tonifying and the like. The traditional Chinese medicine compound preparation formulation has no influence on the drug effect, and test results show that the powder and the granules are effective in preventing and treating salpingitis of laying hens.
Claims (7)
1. The traditional Chinese medicine composition for treating salpingitis of laying hens is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 20-30 parts of well grass, 10-20 parts of shield fruit grass, 8-12 parts of amaranthus auriculata, 6-12 parts of large fruit euonymus alatus, 20-30 parts of azulene root, 10-20 parts of glorious gloriosa root, 6-12 parts of Chinese angelica, 6-12 parts of glossy privet fruit and 10-20 parts of campanumaea acum.
2. The traditional Chinese medicine composition for treating salpingitis of laying hens according to claim 1 is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 23-27 parts of well grass, 12-18 parts of shield fruit grass, 9-11 parts of amaranthus auriculata, 8-10 parts of large fruit euonymus alatus, 23-27 parts of azulene root, 12-18 parts of abacus root, 8-10 parts of Chinese angelica, 8-10 parts of glossy privet fruit and 12-18 parts of campanumoea.
3. The traditional Chinese medicine composition for treating salpingitis of laying hens according to claim 2 is characterized by comprising the following traditional Chinese medicinal materials in parts by weight: 25 parts of well grass, 15 parts of peltate yam herb, 10 parts of amaranthus auriculatus, 10 parts of large fruit euonymus alatus, 25 parts of azulene root, 15 parts of gloriosa root, 10 parts of angelica sinensis, 10 parts of glossy privet fruit and 15 parts of campanumoea.
4. The traditional Chinese medicine composition for treating salpingitis of laying hens according to claim 1, 2 or 3, further comprising pharmaceutically acceptable auxiliary materials.
5. The traditional Chinese medicine composition for treating salpingitis of laying hens according to claim 4, wherein the traditional Chinese medicine composition is: granule, oral liquid, decoction, powder, pill or tablet.
6. The traditional Chinese medicine composition according to claim 5, wherein the dosage form of the traditional Chinese medicine composition is a granule.
7. A method for preparing the traditional Chinese medicine composition according to claim 1, which is characterized in that the method comprises the following steps:
firstly, weighing the raw medicinal materials according to the parts by weight: 20-30 parts of well grass, 10-20 parts of shield fruit grass, 8-12 parts of amaranthus auriculata, 6-12 parts of large fruit euonymus alatus, 20-30 parts of azulene root, 10-20 parts of gloriosa albo-marginata root, 6-12 parts of Chinese angelica, 6-12 parts of glossy privet fruit and 10-20 parts of campanumaea acutifera; cleaning, oven drying, cutting, and mixing;
secondly, adding water which is 8-10 times of the total weight of all the medicinal materials, and soaking the sieved raw medicinal materials in the first step for 0.5-1h; then decocting with slow fire for 1.5h after boiling;
thirdly, filtering the traditional Chinese medicine obtained in the second step, and adding water which is 7-9 times of the total weight of the medicinal materials into filter residues for decoction for 1h;
fourth, filtering the traditional Chinese medicine obtained in the third step, and adding water which is 6-8 times of the total weight of the medicinal materials to decoct for 1h;
fifthly, merging the three decocted liquid medicines, standing for 24 hours, concentrating under reduced pressure until the relative density is 1.12-1.16, and cooling for standby to obtain traditional Chinese medicine fluid extract;
step six, slowly adding 70% ethanol with the amount of 2-2.5 times of the weight of the liquid medicine into the traditional Chinese medicine fluid extract obtained in the step five, standing for 24-48h, uniformly stirring, hermetically refrigerating for 24-48h, filtering, recovering the ethanol of the filtrate, and concentrating to obtain the traditional Chinese medicine fluid extract with the relative density of 1.33-1.36;
seventh, spray drying, granulating, sterilizing and sub-packaging the traditional Chinese medicine fluid extract obtained in the sixth step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311215762.9A CN116942745B (en) | 2023-09-20 | 2023-09-20 | Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311215762.9A CN116942745B (en) | 2023-09-20 | 2023-09-20 | Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116942745A CN116942745A (en) | 2023-10-27 |
| CN116942745B true CN116942745B (en) | 2023-12-08 |
Family
ID=88460496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311215762.9A Active CN116942745B (en) | 2023-09-20 | 2023-09-20 | Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116942745B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100869394B1 (en) * | 2007-08-06 | 2008-11-21 | 김선기 | Traditional oriental medicine egg-laying reinforcing agent and thereof manufacture method |
| CN104740068A (en) * | 2015-04-08 | 2015-07-01 | 杜心洁 | Traditional Chinese medicine for treating accumulated damp heat chronic pelvic inflammation and preparation method thereof |
| KR20170125270A (en) * | 2016-05-04 | 2017-11-14 | 란핑 리우 | A chinese medicine for treating infertility due to oviduct jam |
| CN108771754A (en) * | 2018-08-02 | 2018-11-09 | 河南牧翔动物药业有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating laying hen middle and later periods salpingitis |
| CN109172759A (en) * | 2018-11-29 | 2019-01-11 | 唐山市贝乐宠物医院有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating infectious bronchitis of chicken and the damage of anti-fallopian tubal |
| AU2020101970A4 (en) * | 2020-06-11 | 2020-10-01 | Chengdu Fenglan Technology Co.,Ltd. | Biological feed for improving laying performance and egg quality of laying hen at later laying stage and preparation method thereof |
| CN112546172A (en) * | 2019-11-30 | 2021-03-26 | 河南森隆动物保健品有限公司 | Chinese and western medicine composition for treating salpingitis and preparation method thereof |
| CN114209734A (en) * | 2021-12-10 | 2022-03-22 | 南京农业大学 | Traditional Chinese medicine composition for improving laying performance of laying hens as well as preparation method and application of traditional Chinese medicine composition |
-
2023
- 2023-09-20 CN CN202311215762.9A patent/CN116942745B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100869394B1 (en) * | 2007-08-06 | 2008-11-21 | 김선기 | Traditional oriental medicine egg-laying reinforcing agent and thereof manufacture method |
| CN104740068A (en) * | 2015-04-08 | 2015-07-01 | 杜心洁 | Traditional Chinese medicine for treating accumulated damp heat chronic pelvic inflammation and preparation method thereof |
| KR20170125270A (en) * | 2016-05-04 | 2017-11-14 | 란핑 리우 | A chinese medicine for treating infertility due to oviduct jam |
| CN108771754A (en) * | 2018-08-02 | 2018-11-09 | 河南牧翔动物药业有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating laying hen middle and later periods salpingitis |
| CN109172759A (en) * | 2018-11-29 | 2019-01-11 | 唐山市贝乐宠物医院有限公司 | A kind of Chinese materia medica preparation and preparation method thereof for treating infectious bronchitis of chicken and the damage of anti-fallopian tubal |
| CN112546172A (en) * | 2019-11-30 | 2021-03-26 | 河南森隆动物保健品有限公司 | Chinese and western medicine composition for treating salpingitis and preparation method thereof |
| AU2020101970A4 (en) * | 2020-06-11 | 2020-10-01 | Chengdu Fenglan Technology Co.,Ltd. | Biological feed for improving laying performance and egg quality of laying hen at later laying stage and preparation method thereof |
| CN114209734A (en) * | 2021-12-10 | 2022-03-22 | 南京农业大学 | Traditional Chinese medicine composition for improving laying performance of laying hens as well as preparation method and application of traditional Chinese medicine composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116942745A (en) | 2023-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488848B (en) | Traditional Chinese medicine composition used for treating high-pathogenicity porcine reproductive and respiratory syndrome, preparation method thereof, and application thereof | |
| CN104012798A (en) | Feed for treating endometritis of sow, traditional Chinese medicine composition and preparation method | |
| CN105166545A (en) | Bovine compound feed and preparation method thereof | |
| CN104258139A (en) | Pharmaceutical composition for preventing and treating chronic swine plague and preparation method of pharmaceutical composition | |
| CN105853878A (en) | Body strengthening and life prolonging traditional Chinese medicine composition and preparation method thereof | |
| CN102526510A (en) | Chinese composition for preventing and treating duck virus hepatitis | |
| KR101600751B1 (en) | Method of preparing oriental medicine composition containing extract of deer antlers for treating infertility in women | |
| CN116942745B (en) | Traditional Chinese medicine composition for treating salpingitis of laying hens and preparation method thereof | |
| CN104208524A (en) | Medicine for treating piglet dysentery | |
| CN114886961A (en) | Traditional Chinese medicine composition for treating/preventing avian gout and preparation method and application thereof | |
| CN103239667A (en) | Chinese traditional medicine for treating foot-and-mouth disease of domestic animals | |
| CN108272983B (en) | Hematochezia mixture for treating internal hemorrhoid bleeding and preparation method thereof | |
| CN105663575A (en) | Traditional Chinese medicine composition for preventing and treating swine fever and preparation method of traditional Chinese medicine composition | |
| CN104771585A (en) | Traditional Chinese medicine composition for treating acute nephritis and preparation method thereof | |
| CN104042976A (en) | Medicament for treatment of rheumatism arthritis pains and preparation method thereof | |
| CN103239673B (en) | Traditional Chinese medicine composition for preventing and curing sudden death syndrome of cow | |
| AU2021102946A4 (en) | Chinese Herbal Medicine Complete Feed for Piglets and Preparation Method Thereof | |
| CN105688171B (en) | Feed additive for chicks and preparation method thereof | |
| CN106107036A (en) | A kind of livestock fodder additives with epidemic prevention function | |
| CN106310226A (en) | Chinese herbal medicine compound preparation for preventing and treating piglet dysentery and preparation method thereof | |
| CN105901352A (en) | Feed additive for improving milk yield of milk cow and preparation method thereof | |
| WO2021103238A1 (en) | Traditional chinese medicine compound preparation for preventing and treating porcine diarrhea and preparation method therefor | |
| CN105770779A (en) | Medicine composition for preventing and treating contagious bovine pleuropneumonia and preparation method thereof | |
| CN105435034A (en) | Medicine for treating hemoptysis and preparation method thereof | |
| CN103705820B (en) | Medicine being used for the treatment of yellow scour of piglet and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |