CN105853878A - Body strengthening and life prolonging traditional Chinese medicine composition and preparation method thereof - Google Patents
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Abstract
The invention provides a body strengthening and life prolonging traditional Chinese medicine composition and a preparation method thereof. The composition is prepared from chicken and duck embryo extracts, tortoise egg extracts, red ginseng, cornu cervi pantotrichum, sea horse, fruit of Chinese wolfberry, clove, pangolin, encephalon passeris, roots of bidentate achyranthes, cynomorium songaricum, prepared rehmannia roots, fructus psoraleae, seeds of Chinese dodder, eucommia barks, spirifer, herba cistanche, liquorice roots, asparagus cochinchinensis, epimedium, halite and fructus amomi. The composition has the effects of nourishing the brain, strengthening the kidney, enhancing the functions, prolonging the life and the like, and is mainly used for the symptoms of deficiency of vital energy and blood, amnesia, insomnia, inappetence, waist and back pain, yin and yang weak, impotence and premature ejaculation, cold uterus, postpartum weakness and the like. The composition has the advantages that the preparation process is simple, and the composition is very suitable for industrial production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition built up one's health and prolong one's life and preparation method thereof, belong to the technical field of Chinese medicine.
Background technology
Immunity refers to that human immune system resists the ability of pathogenic infection.Immune system is by thymus (adolescence
Later the most gradually atrophy, degeneration), the composition such as spleen and lymphoid tissue.One sound human immune system is
The system of defense that body is main, can protect body to be without prejudice, and helps body to eliminate external antibacterial, virus,
Repair organ in damaged condition and tissue makes it recover original function etc..And everyone immunity is different
, the people that immunity is strong is difficult to sick, and the weak people of immunity is easily induced various disease by pathogenic bacterial infection.
Investigating according to World Health Organization (WHO), the whole world there are about the people of more than 35% and is in hypoimmunity state, especially
Middle-aged male crowd fatigue state person is up to 60-75%.Expert points out, extended sleep is the best, it is the most tired to continue
Labor easily causes chronic pharyngolaryngitis, cervical region or axillary gland to swell and ache, muscular soreness and multiple arthrosis pass
The diseases such as joint pain, ultimately result in immunity degradation, and after immunity degradation, make again " fatigue syndrome "
More highlight and deteriorate, thus forming a vicious cycle.Along with the development of society, the progress of science and technology, life
Enriching of the quickening of rhythm, culture and material life, not only middle-aged and elderly people is in the fatigue state of subhealth state, blue or green
There is fatigue phenomenon in teenager.
In recent years, along with the raising day by day of people's living standard, the common people start to pursue matter of preferably living
Amount and higher health level, make the numerous common people begin with for building up one's health and prolong one's life healthy, the serious hope of life lengthening
Increasing concern；The transformation of medical model, advocate defence, health care, rehabilitation combine with Drug therapy,
It is main to be changed into put prevention first to disease by treatment, is greatly promoted the development of Health-care Foods Industry；Country is also
Take measures to support and encourage the exploitation of the product that builds up one's health and prolong one's life in policy.
Chinese medicine health preserving, through the development of thousand of years, has deep theoretical basis and practical experience；Traditional
It is Chinese nation's understanding human life that Chinese medicine builds up one's health and prolong one's life, safeguard the healthy and then wisdom knot of life prolonging
Crystalline substance and culture rarity；From the point of view of the thinking of the traditional Chinese medical science, subhealth state shape is that cloudy or positive inclined Sheng declines partially or both decline the most partially
A kind of state, simply pole state did not also occur, beyond the scope of YIN and YANG maintaining in a changeable equilibrium, but trend is
Aobvious；So can be selected for without toxic component or untoward reaction few, the stronger Chinese medicine of safety is made to finely tune negative and positive,
It is allowed to revert to the health status of " YIN and YANG in a relative equilibrium ".
At present, using Chinese medicine, individually or compatibility uses more and more abundanter as the research of the health product that build up one's health and prolong one's life,
Relevant report emerges in an endless stream, health-product market also enlivens as Colla Corii Asini, life one, the heart source element, Onlly many
Large quantities of Chinese medicine health care product such as nation；But existing health product generally exist that drug effect is on the low side, health-care effect is inconspicuous,
The defects such as safety is bad, fail to meet consumer demand.
After animal embryo refers to that male sex-cell and female sex cell are combined into zygote, through the thinnest
What born of the same parents' division and cell were formed after breaking up has the young body of the ability developing into biological adult.Research and development find animal embryo
Extract contains slow down aging, strengthens the material of human body resistivity, such as the sheep placental extract etc. in sheep embryo, closely
It is the most active year as raw material, animal embryo to be carried out health product development activities, such as patent CN101269091A,
Disclose a kind of method using Stichopus japonicus embryo to make nutrition lyophilized powder, use Stichopus japonicus embryo to make nutrition lyophilized powder,
There is alleviating physical fatigue, enhancing immunity effect；Patent CN1135935C discloses a kind of anti-ageing healthcare
Food and manufacture method, utilize fowl embryo to make health food and have resisting fatigue, improve immunity of organisms and anti-ageing
Old effect.Patent CN104757603A discloses a kind of Testudinis embryo product and preparation method thereof, utilizes crow
Testudinis embryo makes health product and has certain enhancing immunologic function.But generally still there is the best the asking of health-care effect
Topic, therefore, researches and develops a kind of health-care effect significant Chinese medicine health-care series products and has extensive and far-reaching meaning
Justice.
Summary of the invention
It is an object of the invention to be to provide a kind of Chinese medicine composition built up one's health and prolong one's life, it is solid that said composition has supplementing the brain
Kidney, strong function, the effect such as life lengthening；It is mainly used in deficiency of vital energy blood weak, forgetful insomnia, inappetence, waist
Acid backache, deficiency of YIN sun is weak, impotence and premature ejaculation, and cold womb is suffered from abdominal pain, puerperal the symptom such as all void.
Specifically, a kind of Chinese medicine composition built up one's health and prolong one's life, it is made up of following weight: chicken and duck embryo carry
Take thing 30-50 part, tortoise egg extract 20-50 part, Radix Ginseng Rubra 10-50 part, Cornu Cervi Pantotrichum 5-20 part, Hippocampus 10-30
Part, Fructus Lycii 10-30 part, Flos Caryophylli 5-20 part, Squama Manis 10-30 part, Medulla passeris 10-30 part, Radix Achyranthis Bidentatae 10-30
Part, Herba Cynomorii 10-30 part, Radix Rehmanniae Preparata 10-30 part, Fructus Psoraleae 10-50 part, Semen Cuscutae 10-50 part, the Cortex Eucommiae
10-30 part, Fossilia Spiriferis 10-30 part, Herba Cistanches 10-30 part, Radix Glycyrrhizae 5-20 part, Radix Asparagi 10-30 part, excessive
Sheep leaves of pulse plants 10-50 part, halite 10-20 part, Fructus Amomi 10-30 part.
Preferably, a kind of Chinese medicine composition built up one's health and prolong one's life, it is made up of following weight: chicken and duck embryo carry
Take thing 40 parts, tortoise egg extract 35 parts, Radix Ginseng Rubra 30 parts, 12.5 parts of Cornu Cervi Pantotrichum, Hippocampus 20 parts, Fructus Lycii
Son 20 parts, Flos Caryophylli 12.5 parts, Squama Manis 20 parts, Medulla passeris 20 parts, Radix Achyranthis Bidentatae 20 parts, Herba Cynomorii 20 parts, ripe
Radix Rehmanniae 20 parts, Fructus Psoraleae 30 parts, Semen Cuscutae 30 parts, the Cortex Eucommiae 20 parts, 20 parts of Fossilia Spiriferis, Herba Cistanches 20 parts,
12.5 parts of Radix Glycyrrhizae, Radix Asparagi 20 parts, Herba Epimedii 30 parts, halite 15 parts, Fructus Amomi 20 parts.
Chicken and duck embryo extract of the present invention is made up of following steps: takes chicken and duck and hatches 10-20 days
Egg is cleaned with the ethanol of 75%, breaks eggshell into pieces, takes out embryo, removes allantois, shreds, with double containing high concentration
Anti-D-Hanks liquid cleans, then cleans by DMEM culture medium；Embryo is put in even oar machine after cleaning
Even oar；The even oar of sucking-off, enters-80 DEG C of refrigerators, multigelation 3 times, is centrifuged, and after being centrifuged, draws
Supernatant constant volume, filter, degerming after embryo extract be placed at 4 DEG C standby.
Described tortoise egg extract is made up of following steps: takes tortoise egg and cleans with the ethanol of 75%,
Break eggshell into pieces, egg liquid is poured in bioreactor and blends, make albumen and egg yolk mixing, be placed at 4 DEG C standby.
Compositions of the present invention is in use, can be mixing of directly pulverizing, it is also possible to be by Chinese medicine
Material extracts active component through this area conventional extraction techniques, with chicken and duck embryo extract, tortoise egg extract
Mixing；Mix with pharmaceutically acceptable pharmaceutic adjuvant again, make various pharmaceutical dosage form.
Described excipient substance can be sweeting agent, preservative, wetting agent, lubricant, wetting agent, disintegrating agent,
Diluent, binding agent.
Described pharmaceutical dosage form can be syrup, tablet, capsule, granule, pill, oral cavity sugar, excellent
Buccal tablets, oral cavity sugar are made in choosing.
When making oral cavity sugar, it is prepared from accordance with the following methods:
By Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata
Huang, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii, halite, sand
Core is sufficiently mixed, and adds 8-10 times amount water reflux, extract, 3 times, each 1-2 hour, and extracting solution filters, and merges
Filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 60-80%, quiet
Put 24 hours, take supernatant, 200 mesh filter, reclaim ethanol, be concentrated into the relative density when 60 DEG C be 1.25～
1.30, obtain oral cavity soaking with sugar cream, addition chicken and duck embryo extract, tortoise egg extract are sufficiently mixed, and add
Hydroxyl isomaltulose, Mentholum, Oleum Eucalypti, sweeting agent, uniformly it is in harmonious proportion and stirs 30 minutes；Then will be in harmonious proportion
Sugar liquid injects cast machine, and cast machine is shaped tractive technique, and packer is packed after cooling, system
Become oral cavity sugar.
When making buccal tablets, it is prepared from accordance with the following methods:
By Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata
Huang, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii, halite, sand
Core is sufficiently mixed, and adds 8-10 times amount water reflux, extract, 3 times, each 1-2 hour, and extracting solution filters, and merges
Filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 60-80%, quiet
Put 24 hours, take supernatant, 200 mesh filter, reclaim ethanol, be concentrated into the relative density when 60 DEG C be 1.25～
1.30；Then under the conditions of 50-80 DEG C, reduced vacuum is dried, and dried cream powder broken mistake 80 mesh sieve, with chicken and duck embryo
Extract, tortoise egg extract are sufficiently mixed, and obtain mixture standby；Take the PVP K30 that weight ratio is 1:11
And mannitol, total consumption is the 70-80% of raw mixture, supplementary material mix homogeneously, with the ethanol of 80-95%
Pelletizing, 40-60 DEG C is dried, and granulate sprays into the Mentholum having used anhydrous alcohol solution of gross weight 3-5%,
Room temperature flings to dehydrated alcohol, adds the magnesium stearate of gross weight 0.5-1%, mix homogeneously, tabletting, then
With the film coating pre-mix dose coating of gross weight 0.5-1%, obtain buccal tablet.
Each ingredient properties and effect that the present invention uses are as follows:
Animal embryo: animal embryo extract contains substantial amounts of protein and peptide, possibly together with substantial amounts of ferrum, phosphorus,
The trace element such as calcium, have YIN nourishing and YANG strengthening and keep fit effect of QI invigorating and the function such as cosmetology and health, blood clean；
Radix Ginseng Rubra: nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return spleen, lung, heart channel；Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly,
Nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis；Heart failure, cardiogenic
Shock.
Cornu Cervi Pantotrichum: nature and flavor: sweet, salty, temperature.Return kidney, Liver Channel.Invigorating kidney-YANG, mends marrow, bone and muscle strengthening, adjusts punching to appoint,
Torr sore.
Hippocampus: warm in nature, sweet in the mouth, have kidney invigorating and YANG supporting, temperature promoting blood circulation, tranquillizing and allaying excitement, cure mainly suffer from a deficiency of the kidney, sexual impotence,
The enuresis.
Fructus Lycii: sweet in the mouth；Property flat.Return Liver Channel；Kidney channel；Lung meridian.Nourishing the liver；Nourishing kidney；Lung moistening.
Flos Caryophylli: nature and flavor: pungent, temperature.Return spleen, stomach, lung, kidney channel.Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For spleen
Insufficiency of stomach is trembled with fear, and singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Squama Manis: salty in the mouth；Cold nature；Return liver, stomach warp.Blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.
Medulla passeris: for the brains of Passeris montani saturati, taste is flat, enters kidney, and Xing Yang lets out essence.
Radix Achyranthis Bidentatae: Gui Jing: liver；Kidney channel.Invigorating the liver and kidney；Bone and muscle strengthening；Promoting blood circulation to restore menstrual flow；Ignite (blood) descending；Profit
Urinate treating stranguria.
Herba Cynomorii: nature and flavor: sweet, temperature；Big nourishing YIN gas, benefiting essence-blood, profit stool.
Radix Rehmanniae Preparata: sweet in the mouth；Warm in nature, return liver；Kidney channel.Enrich blood moist；Benefit essence fills out marrow.
Fructus Psoraleae: nature and flavor are pungent, bitter, temperature；Return kidney, spleen channel.There are warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, effect of antidiarrheal.
For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea；
Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat nontoxic.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.It is applicable to deficiency of the liver and kindey
Waist knee joint muscles and bones is ached, and legs and feet weakness, impotence and seminal emission, frequent micturition, dripping urination, dizziness and blurred vision, regards
Thing is unclear, Hiccough and deaf and the disease such as women's leukorrhagia, habitual abortion.
The Cortex Eucommiae: its sweet in the mouth, warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, consolidate through antiabortive effect.
Fossilia Spiriferis: nature and flavor are sweet, temperature, nontoxic.Tonifying YANG, warm waist knee joint, add essence and mend marrow, QI invigorating, moisten skin, contracting
Urine, imperial wind and cold, haze miasma, pestilence gas.
Herba Cistanches: sweet in the mouth, salty, warm in nature.Gui Jing, returns kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, intestine moistening road.
Main kidney yang deficiency, the sexual impotence of asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, lumbago flaccidity of the lower limbs, tinnitus mesh flower,
Menstruation is spread out the phase, infertility, dryness of the intestine constipation.
Radix Glycyrrhizae: sweet in the mouth is sweet, property is gentle, enters the heart, spleen, lung, stomach four warp.Raw with cooler, can eliminating fire and detoxication,
Relieving spasm to stop pain；Process by temperature partially, exterior cold, invigorating the spleen and replenishing QI can be dissipated.
Radix Asparagi: sweet, bitter, cold.Return lung, kidney channel.Nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough,
Expectoration sticks, dry throat and mouth, dryness of the intestine constipation.
Herba Epimedii: acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Lose for sexual impotence
Essence, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture；Climacteric hypertension.
Halite: nature and flavor are salty；Cold；Nontoxic, GUIXIN, kidney, liver, lung, bladder warp.Cure mainly purge heat, removing heat from blood,
Improving eyesight, moisturize.
Fructus Amomi: nature and flavor: acrid in the mouth, warm in nature.Return spleen channel, stomach warp, kidney channel.Removing dampness is whetted the appetite, warming spleen and stopping diarrha, reason
Gas is antiabortive.
The present invention is according to theory of Chinese medical science prescription, and the deficiency syndrome of the traditional Chinese medical science are mainly seen in the immune disease of modern medicine and suffer from
Person, the traditional Chinese medical science thinks that " void person, the positive deficiency of vital energy is also；Thin for the miserable shape of color, decline timidness due to deficiency of QI for god ... all deficiency syndrome when mending also.
The traditional Chinese medical science is said " in healthy energy is deposited, heresy can not be done, being gathered of heresy, and its gas must be empty ".Subhealth state shape is cloudy or positive
It is caused that a kind of state that Sheng declines partially or both decline the most partially partially, i.e. " YIN and YANG in a relative equilibrium " are unbalance.The present invention is through a large amount of
Prescription is studied, and uses animal embryo extract compatibility each taste Chinese medicine, YIN nourishing and YANG strengthening, keeps fit QI invigorating, finely tunes negative and positive,
22 taste medicines, complement each other, and play the effect of mutual Synergistic, are allowed to revert to " YIN and YANG in a relative equilibrium "
Health status.Being compared with the prior art, this prescription overcomes existing health product, and generally to there is health care inconspicuous
Deficiency, there is supplementing the brain and reinforce the kidney, strong function, the effect such as life lengthening；It is mainly used in deficiency of vital energy blood weak, forgetful
Insomnia, inappetence, sore waist and aching in the waist and the back, deficiency of YIN sun is weak, impotence and premature ejaculation, and cold womb is suffered from abdominal pain, puerperal the symptom such as all void.
The present invention, in order to preferably illustrate the beneficial effect of innovation and creation, has also listed part test example, it is intended to say
The technique effect of the bright present invention, never limits the scope of the present invention.
Test example 1, pharmacodynamic study
1, material
1.1 medicine
Test group 1: the health product (low component) that embodiment 1 prepares, mouse stomach is administered；
Test group 2: the health product that embodiment 2 prepares, mouse stomach is administered；
Test group 3: the health product that embodiment 3 prepares, mouse stomach is administered；
Test group 4: the health product that embodiment 4 prepares, mouse stomach is administered；
Test group 5: the health product (high component) that embodiment 2 prepares, mouse stomach is administered；
Matched group 1: longevity powder capsule, Shanxi Guang Yuyuan traditional Chinese medicines company limited produces, and mouse stomach is administered；
Matched group 2: the health product that patent CN1135935C prepares, mouse stomach is administered；
Matched group 3: the health product that patent CN104757603A prepares, mouse stomach is administered；
Matched group 4: Si BiliRRadix Ginseng gastrodia royal jelly oral liquid, mouse stomach is administered；
Blank group: distilled water, mouse stomach is administered.
1.2 animals: Healthy female ICR mice, body weight 18-22g, test mice original body mass equilibrium between each group.
2, experimental technique
Select healthy mice, each Testing index to set mice 120, be divided into 10 groups, often group 12.Each group is little
Mus all presses Isodose continuous per os gavage, blank group gavage equal-volume distilled water, after 30d, surveys every
Immune indexes.
2.1 spleens/body weight ratio and antibody-producting cell test experience
Mice organs/body weight ratios affect experiment: mice organs injection SRBC, puts to death animal after 5d, take thymus,
Spleen is weighed, and calculates internal organs/body weight ratio.Prepare splenocyte suspension simultaneously, carry out antibody-producting cell mensuration.
Mouse antibodies cellulation test experience: take spleen, make cell suspension.By top layer culture medium heating for dissolving
Hanks liquid double with equivalent mixes afterwards, subpackage small test tube, often pipe 0.5ml, then adds 50 μ L in pipe
10%SRBC (v/v prepares with SA liquid), 20 μ L splenocyte suspensions, rapidly after mixing, be poured into brush fine jade
On the slide of lipolysaccharide thin layer, after agar solidification, fragmentation level button is placed on slide frame, puts into CO2Cultivate
Case incubation 1.5h, then joins in slide frame groove with the complement (1:8) of SA liquid dilution, continues incubation 1.5h
After, count hemolysis plaque number.
2.2 mouse spleen lymphocyte transformation experiments
Aseptic take spleen, prepare splenocyte suspension, wash 2 times with Hanks liquid, be centrifuged 10min (1000r/min) every time,
By cell suspension in 1mL RPMI1640 complete culture solution, adjusting cell concentration is 3 × 106Individual/mL.Will be thin
Born of the same parents' suspension point holes adds in 24 well culture plates, every hole 1mL, and a hole adds 75 μ L ConA liquid, another hole
As comparison, put 5%CO2, 37 DEG C of incubators cultivate 72h.Cultivation terminates front 4h, every hole Aspirate supernatant
0.7mL, adds the 0.7mL RPMI1640 complete culture solution without calf serum, is simultaneously introduced MTT 50 μ L,
Continue to cultivate 4h.After cultivation terminates, every hole adds 1mL acid isopropyl alcohol, and piping and druming uniformly, makes purple crystal
It is completely dissolved, at 570nm wavelength, measures OD value, deduct and be not added with ConA hole adding the OD value in ConA hole
OD value represent lymphopoiesis ability.
2.3 mice delayed allergy experiments
Mouse peritoneal injection 2% (v/v) SRBC, after sensitization, 4d measures left back sufficient sole of the foot thickness, then in measurement portion
Position subcutaneous injection 20% (v/v) SRBC, every Mus injects 20 μ L, and after injection, 24h measures left back sufficient sole of the foot portion thickness,
Same position is measured 3 times, takes average.DTH is represented with foot sole of the foot thickness difference (swelling degree of the paw) before and after attacking
Degree.
2.4 mouse antibodies cellulation test experience
Take spleen, make cell suspension.Hanks liquid double with equivalent after the culture medium heating for dissolving of top layer is mixed,
Subpackage small test tube, often pipe 0.5ml, then in pipe, add 50 μ L 10%SRBC (v/v prepares), 20 μ L with SA liquid
Splenocyte suspension, rapidly after mixing, is poured on the slide of brush agarose thin layer, after agar solidification, and will
Fragmentation level button is placed on slide frame, puts into CO2Incubator incubation 1.5h, then with the complement of SA liquid dilution
(1:8) join in slide frame groove, after continuing incubation 1.5h, count hemolysis plaque number.
2.5 Mouse Bloods purify the blood lysin test experience
Taking Sanguis caprae seu ovis, brine 3 times, the most centrifugal (2000r/min) 10min, every Mus is noted through abdominal cavity
Penetrate 2% hematocrit SRBC0.2mL and carry out immunity.After 4d, extract eyeball and take blood in centrifuge tube, place about 1h,
Being peeled off with tube wall by solidification blood, make serum fully analyze, 2000r/min is centrifuged 10min, collects serum.
With SA buffer by serum-dilution.Serum 1mL after dilution is put in test tube, is sequentially added into 10% (V/V)
SRBC0.5mL, complement 1mL.Separately set the control tube (replacing with SA buffer) of not increase serum.Put 37 DEG C of perseverances
After being incubated 25min in tepidarium, ice bath terminates reaction.2000r/min is centrifuged 10min, takes supernatant 1mL,
Add Dou Shi reagent 1mL.Take 10% (V/V) SRBC0.25mL simultaneously, add Dou Shi reagent to 4mL, fully mix,
After placing 10min, sentence control tube in 540nm and make blank, survey each pipe optical density value respectively.The amount of hemolysin
With half hemolysis value (HC50) represent.
2.6 mice carbonic clearance experiments
India ink to mouse tail vein injection 1:3 dilution, treats that prepared Chinese ink injects timing immediately, injects prepared Chinese ink
Rear 10min, takes blood 20 μ L from angular vein clump respectively, and is added into 2mL Na2CO3In solution, with purple
Outer visible spectrophotometer at 600nm wavelength with Na2CO3Solution makees blank densitometric value (OD).Will
Sacrifice, takes liver and spleen is weighed, and calculates phagocytic index.
2.7 NK cells in mice determinations of activity
Before experiment, 24h is by target cell Secondary Culture, washes 3 times with Hanks liquid before application, complete with RPMI1640
It is 4 × 105/mL that full culture fluid adjusts cell concentration.Mice cervical dislocation is put to death, and aseptic takes spleen, prepares spleen
Cell suspension, washes 2 times with Hanks liquid, is centrifuged 10min (1000r/min) every time.Abandon supernatant by cytoplasm
Upspring, add 0.5mL aquesterilisa splitting erythrocyte, after 20s, add 2 times of Hanks liquid of 0.5mL and 8mL
Hanks liquid, centrifugal 10min (1000r/min), trains completely with the 1mL RPMI1640 containing 10% calf serum
Nutrient solution is resuspended, counts after 1% glacial acetic acid dilution, and adjusting cell concentration is 2 × 107/mL.By target cell
Adding 96 well culture plates, every hole 100 μ L, test hole adds 100 μ L splenocytes (effect target is than 50:1), from
So release aperture adds 100 μ L culture fluid, and maximum release aperture adds 100 μ L 1%NP40, cultivates 4h for 37 DEG C,
Centrifugal, take supernatant 100 μ L and put in 96 hole ELISA Plate, add LDH matrix liquid 100 μ L, react 6min,
Reaction, measured value OD value at microplate reader 490nm is terminated with the HCL of 1mol/L.
3, experimental result
3.1 body weight change situations
Before testing, all mices all weigh body weight value；Mice accepts after tested material 30 days, all mices
The most all weighing body weight value, because mice original body mass equalizes, after accepting tested material, body weight is also without significant difference, examination
Test group and positive controls compare with blank group, P > 0.05, thus invention formulation on Mouse Weight without affect.
3.2 immunity measurement results
According to " health-care food evaluation and technical specification " relevant criterion, now experiment acquired results is divided into: dirty
Device/weight ratio pH-value determination pH, comprises spleen/body weight ratio, thymus/body weight ratio, the results are shown in Table 1；Cell is exempted from
Epidemic disease functional examination, comprises mouse spleen lymphocyte conversion impact experiment, tests mice delayed allergy,
The results are shown in Table 2；Humoral immune function measures, and comprises mouse antibodies cellulation test experience, Mouse Blood purifies the blood
Lysin test experience, the results are shown in Table 3；Monocytes/macrophages functional examination, comprises the impact examination of mice carbonic clearance
Test, Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell is tested, and the results are shown in Table 4；NK cytoactive detection, result
It is shown in Table 5.
The impact on mice organs/body weight ratio of each group of the table 1
| Group | Spleen/body weight ratio (× 102) | Thymus/body weight ratio (× 102) |
| Test group 1 | 0.42±0.6 | 0.33±0.07 |
| Test group 2 | 0.42±0.07 | 0.33±0.09 |
| Test group 3 | 0.43±0.03 | 0.32±0.05 |
| Test group 4 | 0.41±0.07 | 0.33±0.06 |
| Test group 5 | 0.44±0.05 | 0.34±0.05 |
| Matched group 1 | 0.43±0.06 | 0.32±0.05 |
| Matched group 2 | 0.42±0.05 | 0.32±0.05 |
| Matched group 3 | 0.43±0.05 | 0.34±0.04 |
| Matched group 4 | 0.42±0.04 | 0.31±0.05 |
| Blank group | 0.41±0.03 | 0.33±0.04 |
Result: each group of impact on mouse spleen/body weight ratio: each test group and positive controls are right with blank
Compare according to group, P 0.05；The each group of impact on mouse thymus/body weight ratio: test group 1-5 and matched group 1-4
Compare with blank group with positive controls, P 0.05；
Conclusion: the pharmaceutical composition of test group 1-5 and matched group 1-4 group to mice organs/body weight ratio without shadow
Ring.
Each group of table 2 is to mouse cell immunity function result
| Group | Lymphocyte proliferation ability (OD difference) | Swelling degree of the paw |
| Test group 1 (low component) | 0.47±0.06 | 0.42mm±0.06mm |
| Test group 2 | 0.68±0.04 | 0.70mm±0.08mm |
| Test group 3 | 0.69±0.06 | 0.70mm±0.07mm |
| Test group 4 | 0.69±0.09 | 0.69mm±0.09mm |
| Test group 5 (high component) | 0.59±0.06 | 0.61mm±0.08mm |
| Matched group 1 | 0.54±0.07 | 0.54mm±0.08mm |
| Matched group 2 | 0.52±0.09 | 0.56mm±0.08mm |
| Matched group 3 | 0.51±0.06 | 0.55mm±0.07mm |
| Matched group 4 | 0.55±0.07 | 0.56mm±0.05mm |
| Blank group | 0.11±0.09 | 0.31mm±0.06mm |
Remarks: lymphocyte proliferation ability: test group 1-5 and matched group 1-4 compare with blank group, P
＜ 0.05；Swelling degree of the paw: test group 1-5 and matched group 1-4 compare with blank group, P ＜ 0.05；
Conclusion: mouse cell immunity test result is positive by each group of this test and matched group, wherein, test group
2-4 effect and matched group 1-4 and height Component comparison, its best results.
Each group of table 3 is to mouse humoral immune function result
Remarks: hemolysis plaque number: test group 1-5 of the present invention and matched group 1-4 compare with blank group, P
＜ 0.05；Half hemolysis value: test group 1-5 of the present invention and matched group 1-4 compare with blank group, P ＜
0.05。
Conclusion: mouse humoral immune function test result is positive by each group of this test, wherein, test group 2-4
Effect and matched group 1-4 and height Component comparison, its effect is the most notable.
Each group of table 4 affects result to mouse monokaryon-macrophage function
Remarks: carbonic clearance ability phagocytic index: test group 1-5 of the present invention and matched group 1-4 and blank group
Relatively, P ＜ 0.05；Half hemolysis value: phagocytosis chicken red blood cell ability phagocytic percentage and phagocytic index test group
1-5 and matched group 1-4 compares with blank group, P ＜ 0.05；
Conclusion: mouse monokaryon-macrophage function result of the test is positive by each group of this test, wherein, test
Group 2-4 effect and matched group 1-4 and height Component comparison, its effect is the most notable.
Each group of table 5 affects result to NK cells in mice activity
Result: test group 1-5 of the present invention and matched group 1-4 compare with blank group, P ＜ 0.05；
Conclusion: each group of this test affects result of the test to Mice Mice NK cytoactive and is positive, wherein, test
Group 2-4 effect and matched group 1-4 and height Component comparison, its effect is the most notable.
Consolidated statement 2-5 data, it can be seen that preferred composition proportioning of the present invention is: chicken and duck embryo extract 30-50
Part, tortoise egg extract 20-50 part, Radix Ginseng Rubra 10-50 part, Cornu Cervi Pantotrichum 5-20 part, Hippocampus 10-30 part, Chinese holly
Fructus Lycii 10-30 part, Flos Caryophylli 5-20 part, Squama Manis 10-30 part, Medulla passeris 10-30 part, Radix Achyranthis Bidentatae 10-30 part,
Herba Cynomorii 10-30 part, Radix Rehmanniae Preparata 10-30 part, Fructus Psoraleae 10-50 part, Semen Cuscutae 10-50 part, Cortex Eucommiae 10-30
Part, Fossilia Spiriferis 10-30 part, Herba Cistanches 10-30 part, Radix Glycyrrhizae 5-20 part, Radix Asparagi 10-30 part, Herba Epimedii 10-50
Part, halite 10-20 part, Fructus Amomi 10-30 part；Use this amount ranges, strengthen mouse cell immunity merit
Energy, humoral immune function, monocytes/macrophages function and NK cytoactive aspect are respond well, the most most preferably
Component is test group 3.
Totally test result indicate that, the spleen lymph that preferred compound composition of the present invention can improve mice is thin
Born of the same parents' multiplication capacity, increase antibody-producting cell number, improve serum hemolysin, strengthen mouse peritoneal huge bite thin
Endocytosis is bitten chicken red blood cell ability, is strengthened mouse monokaryon-macrophage phagocytic function, enhancing NK cells in mice work
Property；On spleen/body weight ratio, thymus/body weight ratio, swelling degree of the paw without impact；Especially add chicken and duck embryo
After placenta extract and tortoise egg extract, significantly improve than existing longevity powder capsule effect, illustrate that the present invention is effective
The action effect of compound composition enhancing immunity notable.
Test example 2: the impact on ripe male mice copulation ejaculation ability
2.1 materials:
2.1.1 medicine:
Invention formulation: the health product that embodiment of the present invention 1-5 prepares.
Comparison medicine: commercially available longevity powder capsule (Shanxi Guang Yuyuan traditional Chinese medicines company limited).
2.1.2 subjects:
Animal Kun Ming mice, cleaning grade；Wistar rat, SPF level, dynamic by Guiyang Medical College experiment
Thing center provides.
2.2 test methods and result
2.2.1 test method
Male mice 70, body weight 30～36g；Female mice is some, body weight 30～36g.By random for hero Mus
It is divided into 3 groups, often group 10.Test group 1-5 (using the health product that the present invention prepares, dosage 0.8g/kg),
Matched group (using comparison medicine, dosage 0.8g/kg) blank group (giving same volume distilled water),
Every day gastric infusion 1 time, the diet of each test group is identical, successive administration 28 days.Last is little by hero after being administered
The only cage of Mus is raised, each female mice of random collocation one during that afternoon 5, and the next morning separates female mice and examines
Look into cloudy bolt, continuous 7 days.If cloudy bolt occurs in female mice, recall and no longer participate in test, go out occurrence with 7 days cloudy bolts
Number summation is that index is added up, and the results are shown in Table 6.
The table 6 impact on male mice copulation ejaculation ability
| Group | Female mice the moon bolt occurrence number |
| Test group 1 (low component) | 20 |
| Test group 2 | 24 |
| Test group 3 | 26 |
| Test group 4 | 25 |
| Test group 5 (high component) | 22 |
| Matched group | 22 |
| Blank group | 12 |
Note: < O.01 test group 1-5, matched group compare P with blank group
Cloudy bolt: observe dams vagina position at post-coitum (the same cage of male and female Mus), if copulation, morning next day can be cloudy in dams
Road junction leaves the public Mus seminal fluid of white, and general Mus is in copulation at midnight, and seminal fluid knot when checking that gets up morning is solid, and white or yellow sticks
It is attached to vaginal orifice, forms cloudy bolt.
Result shows, the health product using test group 1-5 to prepare all can make normal male mice copulation penetrate with matched group
Essence number of times showed increased, and test group 2-4 its produce effect be better than matched group, show the present invention treatment
Determined curative effect in the sexual dysfunction such as sexual impotence, premature ejaculation.
The experimental example 3 impact on the castrated rats erection time
Male rat 70, body weight 80 100g, row bilateral orchidectomy after etherization, postoperative every day
Intramuscular injection penicillin sodium 20,000 U/kg prevents to infect, totally 3 days.Within postoperative 7 days, dividing 7 groups at random, often group l0 is only,
Treatment group (using the health product that embodiment of the present invention 1-5 prepares, dosage 1g/kg), matched group (use
The comparison medicine of test example 2, dosage 1g/kg), blank group (gives same volume distilled water), often
Day gastric infusion 1 time, successive administration 28 days.After last is administered 1h, YSD 1 pharmacology physiology multiplex instrument (freshwater mussel
Port radio two factory) give rat penis portion faces portion's electricity irritation, current intensity 4mA, cycle 50ms, ripple
Wide lms, is designated as, to the erection time, incubation period of erecing from starting stimulation, and result sees attached list 7.
The table 7 impact on the castrated rats erection time
| Group | Eclipse period of penile erection |
| Test group 1 (low component) | 24.03±3.2 |
| Test group 2 | 22.15±6.3 |
| Test group 3 | 21.03±3.1 |
| Test group 4 | 22.15±4.3 |
| Test group 5 (high component) | 24.15±4.6 |
| Matched group | 23.57±4.5 |
| Blank group | 29.35±3.7 |
Note: < O.01 treatment group compares P with blank group.
Result shows, uses the capsule of the present invention can substantially shorten castrated rats eclipse period of penile erection, and tries
Test group 2-4 effect and be better than matched group.Show that prescription scope of the present invention is at the treatment sexual dysfunction such as sexual impotence, premature ejaculation
Middle determined curative effect.
Test example 4: the impact of mouse anti-reflecting fatigue is tested by the present composition:
4.1 test group are administered:
Test group 1: the health product (low component) that embodiment 1 prepares, mouse stomach is administered；
Test group 2: the health product that embodiment 2 prepares, mouse stomach is administered；
Test group 3: the health product that embodiment 3 prepares, mouse stomach is administered；
Test group 4: the health product that embodiment 4 prepares, mouse stomach is administered；
Test group 5: the health product (high component) that embodiment 2 prepares, mouse stomach is administered；
Matched group 1: longevity powder capsule, Shanxi Guang Yuyuan traditional Chinese medicines company limited produces, and mouse stomach is administered；
Matched group 2: the health product that patent CN1135935C prepares, mouse stomach is administered；
Matched group 3: the health product that patent CN104757603A prepares, mouse stomach is administered；
Matched group 4: Si BiliRRadix Ginseng gastrodia royal jelly oral liquid, mouse stomach is administered；
Blank group: distilled water, mouse stomach is administered.
Successive administration 10 days, every day 1 time.It is administered latter 1 hour in last, animal is put into 15 ± 1 DEG C
In swimming groove, observation mice is put into and is sink to the most unable water-bed time floated in water for continuing swimming time.By table
8 results are visible, and the compositions of the present invention can be obviously prolonged mice low temperature continuous swimming time.
Table 8: the invention formulation impact on mice swimming time:
Result of the test shows: the preparation that embodiments of the invention 2-4 prepares can significantly extend the trip of mice low temperature continuous
The swimming time, and its effect relatively matched group 1-4 is the most notable, shows that invention has the ability effect of resisting fatigue to mice
The most ideal.
Above-mentioned test shows: the Chinese medicine composition medication that the present invention prepares is reasonable, and relatively prior art has preferably
Supplementing the brain reinforces the kidney, the function of strong function, life lengthening, at enhancing immunity, building body, fills blood, increases
The strong aspect such as memory and sexual function all has good improvement, and production technology is simple, is build up one's health and prolong one's life another good
Good selection.
Detailed description of the invention
Further illustrate embodiment of the present invention below in conjunction with specific embodiment, but be not intended to the enforcement of the present invention
Scope.
Embodiment 1: one builds up one's health and prolong one's life buccal tablet (low component):
Prescription: chicken and duck embryo extract 25g, tortoise egg extract 18g, Radix Ginseng Rubra 8g, Cornu Cervi Pantotrichum 4g, Hippocampus
5g, Fructus Lycii 7g, Flos Caryophylli 4g, Squama Manis 8g, Medulla passeris 8g, Radix Achyranthis Bidentatae 8g, Herba Cynomorii 8g, Radix Rehmanniae Preparata 8g,
Fructus Psoraleae 8g, Semen Cuscutae 8g, Cortex Eucommiae 8g, Fossilia Spiriferis 8g, Herba Cistanches 8g, Radix Glycyrrhizae 3g, Radix Asparagi 7g, excessive sheep
Leaves of pulse plants 7g, halite 7g, Fructus Amomi 7g；
Preparation method: by Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part,
Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii,
Halite, Fructus Amomi are sufficiently mixed, and add 10 times amount water reflux, extract, 3 times, each 1.5 hours, and extracting solution is filtered
Crossing, merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 80%,
Standing 24 hours, take supernatant, 200 mesh filter, and reclaim ethanol, and being concentrated into the relative density when 60 DEG C is
1.25～1.30；Then under the conditions of 70 DEG C, reduced vacuum is dried, and dried cream powder broken mistake 80 mesh sieve, with chicken and duck embryo
Placenta extract, tortoise egg extract are sufficiently mixed, and obtain mixture standby；Take the polyvidone that weight ratio is 1:10
K30 and mannitol, total consumption is the 80% of raw mixture, and supplementary material mix homogeneously, by the ethanol system of 90%
Grain, 50 DEG C dried, and granulate sprays into the Mentholum having used anhydrous alcohol solution of gross weight 4%, room temperature
Fling to dehydrated alcohol, add the magnesium stearate of gross weight 1%, mix homogeneously, tabletting, then use gross weight
The film coating pre-mix dose coating of 1%, obtains buccal tablet.
Embodiment 2: one build up one's health and prolong one's life oral cavity sugar
Prescription: chicken and duck embryo extract 30g, tortoise egg extract 20g, Radix Ginseng Rubra 10g, Cornu Cervi Pantotrichum 5g, Hippocampus
10g, Fructus Lycii 10g, Flos Caryophylli 5g, Squama Manis 10g, Medulla passeris 10g, Radix Achyranthis Bidentatae 10g, Herba Cynomorii 10g, Radix Rehmanniae Preparata
Yellow 10g, Fructus Psoraleae 10g, Semen Cuscutae 10g, Cortex Eucommiae 10g, Fossilia Spiriferis 10g, Herba Cistanches 10g, Radix Glycyrrhizae 5g,
Radix Asparagi 10g, Herba Epimedii 10g, halite 10g, Fructus Amomi 10g；
Preparation method: by the Radix Ginseng Rubra of above-mentioned recipe quantity, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, passeris montani saturati
Brain, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, sky
Winter, Herba Epimedii, halite, Fructus Amomi are sufficiently mixed, and add 8 times amount water reflux, extract, 3 times, each 1 hour,
Extracting solution filters, and merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to
Alcohol content 70%, stands 24 hours, takes supernatant, and 200 mesh filter, and reclaims ethanol, is concentrated at 60 DEG C
Time relative density be 1.25～1.30, obtain oral cavity soaking with sugar cream, add chicken and duck embryo extract, tortoise egg carries
Take thing to be sufficiently mixed, add hydroxyl isomaltulose, Mentholum, Oleum Eucalypti, sweeting agent, uniformly mediation stirring 30
Minute；Then the sugar liquid being in harmonious proportion being injected cast machine, cast machine is shaped tractive technique, cooled
Rear packer is packed, and makes oral cavity sugar.
Embodiment 3: one builds up one's health and prolong one's life buccal tablet
Prescription: chicken and duck embryo extract 40g, tortoise egg extract 35g, Radix Ginseng Rubra 30g, Cornu Cervi Pantotrichum 12.5g, sea
Horse 20g, Fructus Lycii 20g, Flos Caryophylli 12.5g, Squama Manis 20g, Medulla passeris 20g, Radix Achyranthis Bidentatae 20g, Herba Cynomorii 20g,
Radix Rehmanniae Preparata 20g, Fructus Psoraleae 30g, Semen Cuscutae 30g, Cortex Eucommiae 20g, Fossilia Spiriferis 20g, Herba Cistanches 20g, Radix Glycyrrhizae
12.5g, Radix Asparagi 20g, Herba Epimedii 30g, halite 15g, Fructus Amomi 20g；
Preparation method: by Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part,
Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii,
Halite, Fructus Amomi are sufficiently mixed, and add 10 times amount water reflux, extract, 3 times, each 1.5 hours, and extracting solution is filtered
Crossing, merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 80%,
Standing 24 hours, take supernatant, 200 mesh filter, and reclaim ethanol, and being concentrated into the relative density when 60 DEG C is
1.25～1.30；Then under the conditions of 70 DEG C, reduced vacuum is dried, and dried cream powder broken mistake 80 mesh sieve, with chicken and duck embryo
Placenta extract, tortoise egg extract are sufficiently mixed, and obtain mixture standby；Take the polyvidone that weight ratio is 1:11
K30 and mannitol, total consumption is the 75% of raw mixture, and supplementary material mix homogeneously, by the ethanol system of 90%
Grain, 50 DEG C dried, and granulate sprays into the Mentholum having used anhydrous alcohol solution of gross weight 3%, room temperature
Fling to dehydrated alcohol, add the magnesium stearate of gross weight 1%, mix homogeneously, tabletting, then use gross weight
The film coating pre-mix dose coating of 1%, obtains buccal tablet.
Embodiment 4: one builds up one's health and prolong one's life granule
Prescription: chicken and duck embryo extract 50g, tortoise egg extract 50g, Radix Ginseng Rubra 50g, Cornu Cervi Pantotrichum 20g, Hippocampus
30g, Fructus Lycii 30g, Flos Caryophylli 20g, Squama Manis 30g, Medulla passeris 30g, Radix Achyranthis Bidentatae 30g, Herba Cynomorii 30g, Radix Rehmanniae Preparata
Yellow 30g, Fructus Psoraleae 50g, Semen Cuscutae 50g, Cortex Eucommiae 30g, Fossilia Spiriferis 30g, Herba Cistanches 30g, Radix Glycyrrhizae 20g,
Radix Asparagi 30g, Herba Epimedii 50g, halite 20g, Fructus Amomi 30g；
Preparation method: by the Radix Ginseng Rubra of above-mentioned recipe quantity, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, passeris montani saturati
Brain, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, sky
Winter, Herba Epimedii, halite, Fructus Amomi are sufficiently mixed, and pulverize, and cross 100-200 mesh sieve, add chicken and duck embryo and carry
Take thing, tortoise egg extract is sufficiently mixed, and adds the dextrin of gross weight 50%, the pregelatinized Starch of 15%, uses
10% starch slurry granulation, granulate, i.e. obtain granule after drying.
Embodiment 5: one builds up one's health and prolong one's life buccal tablet (high component):
Prescription: chicken and duck embryo extract 55g, tortoise egg extract 55g, Radix Ginseng Rubra 55g, Cornu Cervi Pantotrichum 25g, Hippocampus
35g, Fructus Lycii 35g, Flos Caryophylli 25g, Squama Manis 35g, Medulla passeris 35g, Radix Achyranthis Bidentatae 35g, Herba Cynomorii 35g, Radix Rehmanniae Preparata
Yellow 35g, Fructus Psoraleae 55g, Semen Cuscutae 55g, Cortex Eucommiae 35g, Fossilia Spiriferis 35g, Herba Cistanches 35g, Radix Glycyrrhizae 25g,
Radix Asparagi 35g, Herba Epimedii 55g, halite 25g, Fructus Amomi 35g；
Preparation method: by Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part,
Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii,
Halite, Fructus Amomi are sufficiently mixed, and add 10 times amount water reflux, extract, 3 times, each 1.5 hours, and extracting solution is filtered
Crossing, merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 80%,
Standing 24 hours, take supernatant, 200 mesh filter, and reclaim ethanol, and being concentrated into the relative density when 60 DEG C is
1.25～1.30；Then under the conditions of 70 DEG C, reduced vacuum is dried, and dried cream powder broken mistake 80 mesh sieve, with chicken and duck embryo
Placenta extract, tortoise egg extract are sufficiently mixed, and obtain mixture standby；Take the polyvidone that weight ratio is 1:11
K30 and mannitol, total consumption is the 75% of raw mixture, and supplementary material mix homogeneously, by the ethanol system of 90%
Grain, 50 DEG C dried, and granulate sprays into the Mentholum having used anhydrous alcohol solution of gross weight 3%, room temperature
Fling to dehydrated alcohol, add the magnesium stearate of gross weight 1%, mix homogeneously, tabletting, then use gross weight
The film coating pre-mix dose coating of 1%, obtains buccal tablet.
Embodiment 6: one builds up one's health and prolong one's life capsule
Prescription: chicken and duck embryo extract 30g, tortoise egg extract 50g, Radix Ginseng Rubra 10g, Cornu Cervi Pantotrichum 20g, Hippocampus
10g, Fructus Lycii 30g, Flos Caryophylli 5g, Squama Manis 30g, Medulla passeris 10g, Radix Achyranthis Bidentatae 30g, Herba Cynomorii 10g, Radix Rehmanniae Preparata
Yellow 30g, Fructus Psoraleae 10g, Semen Cuscutae 50g, Cortex Eucommiae 10g, Fossilia Spiriferis 30g, Herba Cistanches 10g, Radix Glycyrrhizae 20g,
Radix Asparagi 10g, Herba Epimedii 50g, halite 10g, Fructus Amomi 30g；
Preparation method: by the Radix Ginseng Rubra of above-mentioned recipe quantity, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, passeris montani saturati
Brain, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, sky
Winter, Herba Epimedii, halite, Fructus Amomi are sufficiently mixed, and add 8 times amount water reflux, extract, 3 times, each 1 hour,
Extracting solution filters, and merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to
Alcohol content 70%, stands 24 hours, takes supernatant, and 200 mesh filter, and reclaims ethanol, is concentrated at 60 DEG C
Time relative density be 1.25～1.30, obtain extractum, add chicken and duck embryo extract, tortoise egg extract fills
Divide mixing, dried the addition pregelatinized Starch of gross weight 20%, the microcrystalline Cellulose of 15%, use 10% starch slurry
After granulation, granulate, encapsulated, to obtain final product.
Embodiment 7: one builds up one's health and prolong one's life ball
Prescription: chicken and duck embryo extract 50g, tortoise egg extract 20g, Radix Ginseng Rubra 50g, Cornu Cervi Pantotrichum 5g, Hippocampus
30g, Fructus Lycii 10g, Flos Caryophylli 20g, Squama Manis 10g, Medulla passeris 30g, Radix Achyranthis Bidentatae 10g, Herba Cynomorii 30g, Radix Rehmanniae Preparata
Yellow 10g, Fructus Psoraleae 50g, Semen Cuscutae 10g, Cortex Eucommiae 30g, Fossilia Spiriferis 10g, Herba Cistanches 30g, Radix Glycyrrhizae 5g,
Radix Asparagi 30g, Herba Epimedii 10g, halite 20g, Fructus Amomi 10g；
Preparation method: by the Radix Ginseng Rubra of above-mentioned recipe quantity, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, passeris montani saturati
Brain, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, sky
Winter, Herba Epimedii, halite, Fructus Amomi are sufficiently mixed, and add 8 times amount water reflux, extract, 3 times, each 1 hour,
Extracting solution filters, and merging filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to
Alcohol content 70%, stands 24 hours, takes supernatant, and 200 mesh filter, and reclaims ethanol, is concentrated at 60 DEG C
Time relative density be 1.25～1.30, obtain extractum, add chicken and duck embryo extract, tortoise egg extract fills
Divide mixing, make pill by art methods after drying.
Empirical tests, capsule that the present invention obtains, pill, the same granule of drug effect, the buccal tablet etc. such as conventional tablet are suitable,
It is better than the effect of buccal tablet made by low component and high amounts of components, the compositions that builds up one's health and prolong one's life of the present invention is described
Preferable health-care effect, and safety are played.
Claims (9)
1. the Chinese medicine composition built up one's health and prolong one's life, it is characterised in that be made up of following weight: chicken and duck embryo
Placenta extract 30-50 part, tortoise egg extract 20-50 part, Radix Ginseng Rubra 10-50 part, Cornu Cervi Pantotrichum 5-20 part, sea
Horse 10-30 part, Fructus Lycii 10-30 part, Flos Caryophylli 5-20 part, Squama Manis 10-30 part, Medulla passeris 10-30 part,
Radix Achyranthis Bidentatae 10-30 part, Herba Cynomorii 10-30 part, Radix Rehmanniae Preparata 10-30 part, Fructus Psoraleae 10-50 part, Semen Cuscutae 10-50
Part, Cortex Eucommiae 10-30 part, Fossilia Spiriferis 10-30 part, Herba Cistanches 10-30 part, Radix Glycyrrhizae 5-20 part, Radix Asparagi 10-30
Part, Herba Epimedii 10-50 part, halite 10-20 part Fructus Amomi 10-30 part.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 1, it is characterised in that by following heavy
Amount part proportioning is made: chicken and duck embryo extract 40 parts, tortoise egg extract 35 parts, Radix Ginseng Rubra 30 parts, Cornu Cervi Pantotrichum
12.5 parts, Hippocampus 20 parts, Fructus Lycii 20 parts, Flos Caryophylli 12.5 parts, Squama Manis 20 parts, Medulla passeris 20 parts,
Radix Achyranthis Bidentatae 20 parts, Herba Cynomorii 20 parts, Radix Rehmanniae Preparata 20 parts, Fructus Psoraleae 30 parts, Semen Cuscutae 30 parts, the Cortex Eucommiae 20 parts,
20 parts of Fossilia Spiriferis, Herba Cistanches 20 parts, 12.5 parts of Radix Glycyrrhizae, Radix Asparagi 20 parts, Herba Epimedii 30 parts, halite 15
Part, Fructus Amomi 20 parts.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 1 and 2, it is characterised in that described
Chicken and duck embryo extract is made up of following steps: take the egg that chicken and duck is hatched 10-20 days, with the ethanol of 75%
Clean, break eggshell into pieces, take out embryo, remove allantois, shred, with the D-Hanks liquid dual anti-containing high concentration
Clean, then clean by DMEM culture medium；After cleaning, embryo is put into even oar in even oar machine；The even oar of sucking-off,
Enter-80 DEG C of refrigerators, multigelation 3 times, be centrifuged, after being centrifuged, draw supernatant constant volume, filter,
Embryo extract after degerming is placed at 4 DEG C standby；
Described tortoise egg extract is made up of following steps: take tortoise egg, and the ethanol with 75% is cleaned, and breaks egg into pieces
Shell, pours into egg liquid in bioreactor and blends, and makes albumen and egg yolk mixing, is placed at 4 DEG C standby.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 1 and 2, it is characterised in that described
Compositions when application for directly pulverizing mixing, or by Chinese crude drug through this area conventional extraction techniques
The active component extracted, mixes with chicken and duck embryo extract, tortoise egg extract；Again with pharmaceutically acceptable
Pharmaceutic adjuvant mixing, make various pharmaceutical dosage form.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 4, it is characterised in that described medicine
Adjuvant can be sweeting agent, preservative, wetting agent, lubricant, wetting agent, disintegrating agent, diluent and/or
Binding agent.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 4, it is characterised in that described agent
Type is syrup, tablet, capsule, granule, pill.
Chinese medicine composition the most according to claim 6, it is characterised in that the preparation method of oral cavity sugar is as follows:
By Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata
Huang, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii, halite, sand
Core is sufficiently mixed, and adds 8-10 times amount water reflux, extract, 3 times, each 1-2 hour, and extracting solution filters, and merges
Filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 60-80%, quiet
Put 24 hours, take supernatant, 200 mesh filter, reclaim ethanol, be concentrated into the relative density when 60 DEG C be 1.25～
1.30, obtain oral cavity soaking with sugar cream, addition chicken and duck embryo extract, tortoise egg extract are sufficiently mixed, and add
Hydroxyl isomaltulose, Mentholum, Oleum Eucalypti, sweeting agent, uniformly it is in harmonious proportion and stirs 30 minutes；Then will be in harmonious proportion
Sugar liquid injects cast machine, and cast machine is shaped tractive technique, and packer is packed after cooling, system
Become oral cavity sugar.
Chinese medicine composition the most according to claim 6, it is characterised in that the preparation method of buccal tablets is as follows:
By Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Hippocampus, Fructus Lycii, Flos Caryophylli, Squama Manis, Medulla passeris, Radix Achyranthis Bidentatae part, Herba Cynomorii, Radix Rehmanniae Preparata
Huang, Fructus Psoraleae, Semen Cuscutae, the Cortex Eucommiae, Fossilia Spiriferis, Herba Cistanches, Radix Glycyrrhizae, Radix Asparagi, Herba Epimedii, halite, sand
Core is sufficiently mixed, and adds 8-10 times amount water reflux, extract, 3 times, each 1-2 hour, and extracting solution filters, and merges
Filtrate, it is 1.10～1.20 that filtrate is concentrated into the relative density when 60 DEG C, and alcohol is sink to alcohol content 60-80%, quiet
Put 24 hours, take supernatant, 200 mesh filter, reclaim ethanol, be concentrated into the relative density when 60 DEG C be 1.25～
1.30；Then under the conditions of 50-80 DEG C, reduced vacuum is dried, and dried cream powder broken mistake 80 mesh sieve, with chicken and duck embryo
Extract, tortoise egg extract are sufficiently mixed, and obtain mixture standby；Take the PVP K30 that weight ratio is 1:11
And mannitol, total consumption is the 70-80% of raw mixture, supplementary material mix homogeneously, with the ethanol of 80-95%
Pelletizing, 40-60 DEG C is dried, and granulate sprays into the Mentholum having used anhydrous alcohol solution of gross weight 3-5%,
Room temperature flings to dehydrated alcohol, adds the magnesium stearate of gross weight 0.5-1%, mix homogeneously, tabletting, then
With the film coating pre-mix dose coating of gross weight 0.5-1%, obtain buccal tablet.
A kind of Chinese medicine composition built up one's health and prolong one's life the most according to claim 1 and 2, it is characterised in that described
Compositions has supplementing the brain and reinforces the kidney, strong function, and life lengthening effect is weak for deficiency of vital energy blood, forgetful insomnia, food
Be intended to depressed, sore waist and aching in the waist and the back, deficiency of YIN sun is weak, impotence and premature ejaculation, cold womb suffer from abdominal pain, puerperal all void application.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214958A (en) * | 2016-08-26 | 2016-12-14 | 贵州神奇药物研究院 | A kind of health beverage of slow down aging and preparation method thereof |
| CN108014269A (en) * | 2017-12-18 | 2018-05-11 | 高意强 | A kind of medicinal liquor of tonifying kidney and benefiting sperm |
| CN108607026A (en) * | 2018-05-31 | 2018-10-02 | 马秀群 | A kind of reinvigoration, the composition and preparation method thereof to prolong life |
| CN109106679A (en) * | 2018-11-01 | 2019-01-01 | 独角兽生命科学股份公司 | Anti-ageing Regeneration and Repair liquid of skin and preparation method thereof |
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| CN1342461A (en) * | 2000-09-08 | 2002-04-03 | 邹清雁 | Process for preparing embryo nutrient |
| CN101284115A (en) * | 2008-05-30 | 2008-10-15 | 连德峰 | Kidney-tonifying and body-strengthening pellet and production technique thereof |
| CN105106426A (en) * | 2015-08-07 | 2015-12-02 | 刘振标 | Ginseng and antler wine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1342461A (en) * | 2000-09-08 | 2002-04-03 | 邹清雁 | Process for preparing embryo nutrient |
| CN101284115A (en) * | 2008-05-30 | 2008-10-15 | 连德峰 | Kidney-tonifying and body-strengthening pellet and production technique thereof |
| CN105106426A (en) * | 2015-08-07 | 2015-12-02 | 刘振标 | Ginseng and antler wine |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214958A (en) * | 2016-08-26 | 2016-12-14 | 贵州神奇药物研究院 | A kind of health beverage of slow down aging and preparation method thereof |
| CN108014269A (en) * | 2017-12-18 | 2018-05-11 | 高意强 | A kind of medicinal liquor of tonifying kidney and benefiting sperm |
| CN108607026A (en) * | 2018-05-31 | 2018-10-02 | 马秀群 | A kind of reinvigoration, the composition and preparation method thereof to prolong life |
| CN109106679A (en) * | 2018-11-01 | 2019-01-01 | 独角兽生命科学股份公司 | Anti-ageing Regeneration and Repair liquid of skin and preparation method thereof |
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