CN103735832B - Medicine being used for the treatment of Chicken salpingitis and preparation method thereof - Google Patents

Medicine being used for the treatment of Chicken salpingitis and preparation method thereof Download PDF

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CN103735832B
CN103735832B CN201410040062.5A CN201410040062A CN103735832B CN 103735832 B CN103735832 B CN 103735832B CN 201410040062 A CN201410040062 A CN 201410040062A CN 103735832 B CN103735832 B CN 103735832B
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CN103735832A (en
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李鑫
黄河
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Shandong New Hope Liuhe Group Co Ltd
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Abstract

The invention discloses a kind of medicine being used for the treatment of Chicken salpingitis and preparation method thereof, medicine comprises following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.The invention has the beneficial effects as follows: medicine of the present invention with element culturing fixed folder, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis and dredge the collateral for primary treatment principle, at treatment Chicken salpingitis, there is therapeutic effect obvious, healing time is short, have no side effect, the advantage of drug residue free, and laying rate of laying hen, the body constitution strengthening laying hen and premunition can be improved.

Description

Medicine being used for the treatment of Chicken salpingitis and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of medicine being used for the treatment of Chicken salpingitis and preparation method thereof.
Background technology
Chicken salpingitis is the common reproductive system disease of chicken, and cause of disease is one or several mixed infection of antibacterial, mycoplasma, anaerobe and infusorian etc., clinically with ovary, fallopian tube, peritoneal inflammation for feature, follicle distortion time serious, congested, hemorrhage, in bronzing or taupe, even break, break the egg yolk liquid in abdominal cavity, taste stench, follicle shrinkage sometimes, shape is irregular, in golden yellow or brown, matt, when the state of an illness is slightly long, intestinal adhesions, fallopian tube has the cheesy thing of yellow-white.Cause of disease more complicated threatens one of poultry husbandry sound development frequently-occurring disease.
Pouity dwelling place sanitary condition is too poor, and cloaca is polluted by antibacterial (as Salmonella pullorum, Salmonella paratyphi, escherichia coli etc.) and invades fallopian tube; Or feeding animals feedstuff is too much, lay eggs excessive or produce double-yolked egg, eggshell breaks in fallopian tube sometimes, damage fallopian tube; Or lay eggs too much, be deficient in vitamin in feedstuff A, D, E etc. all can cause salpingitis.Poultry suffers from salpingitis, often causes prolapse of fallopian tube, difficult labour etc.
Sick fowl main manifestations is that pain is uneasy, often with bloodstain on its eggshell of the egg of output.Often discharge Huang, white pus sample secretions in fallopian tube, pollute perianal and feather below thereof, difficulty of laying eggs.Along with the development of the state of an illness, sick fowl starts heating, and after heat is moved back, and painful uneasy, stand transfixed to the ground, two wings are sagging, and disorderly, some abdominal paries, by ground or lethargy, can cause peritonitis, or salpingorrhexis cause yolk peritonitis to feather pine when inflammation spreads to abdominal cavity.
Western medical treatment Chicken salpingitis: should isolate inspection immediately after morbidity, rests in cloaca if any egg ovum, pours into lubricant class, impel and excreted by ovum in cloaca.Then cloaca is injected with the potassium permanganate liquid that syringe sucks warm water or low concentration and fallopian tube bottom is rinsed, the egg drop reduction that unknown cause causes: ovum health (100g is watered 2000 jin) jin is drunk water, egg fowl many ovum element+Bai Yang egg good fortune spice; The egg drop reduction that virosis causes: ovum health is drunk water, egg fowl many ovum element+Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of Chicken salpingitis, have successful for treatment Chicken salpingitis, healing time is short, has no side effect, the advantage of drug residue free, and laying rate of laying hen, the body constitution strengthening laying hen and premunition can be improved.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of Chicken salpingitis, described medicine comprises following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion and Radix Glycyrrhizae 10-20 weight portion.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion and Radix Glycyrrhizae 12-19 weight portion.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion and Radix Glycyrrhizae 16 weight portion.
Described medicine also comprises: Cortex Hibisci, Flos Moutan, Litsea chenii, Herba Verbenae and Herba Malvastri Coromandeliani.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Cortex Hibisci 10-15 weight portion, Flos Moutan 10-15 weight portion, Litsea chenii 15-20 weight portion, Herba Verbenae 15-20 weight portion and Herba Malvastri Coromandeliani 15-20 weight portion.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion, Radix Glycyrrhizae 12-19 weight portion, Cortex Hibisci 12-15 weight portion, Flos Moutan 10-13 weight portion, Litsea chenii 15-18 weight portion, Herba Verbenae 15-18 weight portion and Herba Malvastri Coromandeliani 18-20 weight portion.
Described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion, Radix Glycyrrhizae 16 weight portion, Cortex Hibisci 13 weight portion, Flos Moutan 12 weight portion, Litsea chenii 17 weight portion, Herba Verbenae 16 weight portion and Herba Malvastri Coromandeliani 19 weight portion.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of the medicine of Chicken salpingitis, described preparation method comprises:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 2 ~ 3:1;
6th step, at room temperature will leave standstill 12 ~ 24h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, obtain drug powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention with element culturing fixed folder, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis and dredge the collateral for primary treatment principle, at treatment Chicken salpingitis, there is therapeutic effect obvious, healing time is short, have no side effect, the advantage of drug residue free, and laying rate of laying hen, the body constitution strengthening laying hen and premunition can be improved.
Detailed description of the invention
Theoretical according to Chinese veterinarian, along with the development of poultry husbandry, fowl disease becomes increasingly complex.In laying hen production process, normal generation produces with laying hen the class epidemic disease that soft-preserved egg, shell egg, husky shell egg etc. are feature, is commonly called as hens salpingitis.In doctor trained in Western medicine etiology, cause fallopian tube pathological changes to be mainly the infection such as weak malicious bird flu, atypical newcastle disease, infectious bronchitis, chlamydiosis and colibacillosis, the rule for the treatment of is mainly based on anti-inflammation.And it is improper to take good care of oneself when the traditional Chinese medical science thinks that pathogenic factor mostly is and lays eggs, the evil poison of diseases caused by exogenous pathogenic factor or overwork etc. of laying eggs, the heresy of turbid damp is flooded to twine and is difficult to resolve, and blood stasis not easily removes suddenly, and damp and hot bridle accumulation uterus of a specified duration, causes QI-blood circulation not smooth.Based on above-mentioned theory, the present invention with element culturing fixed folder, clearing away heat-damp and promoting diuresis, activating blood circulation to dissipate blood stasis and dredge the collateral for primary treatment principle, provide a kind of medicine being used for the treatment of Chicken salpingitis, comprise following raw medicinal material: Radix Codonopsis, Radix Rehmanniae Preparata, Herba Carlinae biebersteinii, Fructus Litchi, Rhizoma Nupharis Bornetii, Rhizoma Chuanxiong, Fructus Toosendan, Semen Euryales, Gypsum Fibrosum, Fructus Lycii, Placenta Hominis, Radix Ophiopogonis, Flos Bombacis Malabarici, Retinervus Luffae Fructus and Radix Glycyrrhizae.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, the lung moistening and production of body fluid promoting, and gas in tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, then spleen invigorating fortune and not dry, grow stomach-Yin and not wetting, lung moistening and do not violate cold and cool, nourishes blood and partially do not grow greasy, inspiring clear sun, gas in vibration, and without just dry fraud.Radix Astragali QI invigorating, can enriching spleen-QI be risen, again can lung benefiting consolidating superficial resistance.Radix Codonopsis QI invigorating, can only spleen invigorating QI invigorating, and without the power of consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali is then without the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis is without diuretic effect.This two tastes medicine share can invigorating the spleen and replenishing QI, improves resistance.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature; Return liver, kidney channel.Enrich blood moist; It is sallow that benefit essence fills out marrow blood tiger; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath." herbal classic is met former ": " Radix Rehmanniae Preparata, false firepower steams and shines, and it is sweet for turning hardship, is the yang aspect of yin, therefore vigour in energy the kidney invigorating." generation research, the Dihuang polysaccharide contained by Radix Rehmanniae Preparata has obvious immune antitumor activity, also have significant heart tonifying, diuresis, protect the liver, blood sugar lowering, anti-proliferate, exudation, antiinflammatory, antifungal, the effect such as anti-radiation.
Herba Carlinae biebersteinii: sweet acid; Micro-salty; Temperature.Return spleen; Liver; Kidney channel.Function cures mainly: strengthening the spleen and stomach; Replenishing QI and blood; Tune have through.Main insufficiency of the spleen lack of appetite; Dyspepsia; Deficiency of both QI and blood; Asthenic body; Have through uncomfortable.
Fructus Litchi: sweet; Acid; Temperature.Return spleen; Liver Channel.Function cures mainly: spleen invigorating of nourishing blood; Promoting the circulation of QI for relieving swelling.Main body is after being ill empty, and Tianjin wound is thirsty; Diarrhea due to hypofunction of the spleen; Singultus; Lack of appetite; Scrofula; Furuncle swells; Traumatic hemorrhage.
Rhizoma Nupharis Bornetii: sweet; Bitter; Be slightly cold.Return spleen channel.Function cures mainly: nourishing YIN and clearing away heat.Main impairment caused by overstrain is deficient; Fever due to yin deficiency; Night sweat; External application
Rhizoma Chuanxiong: ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound low dose of contained ferulic acid promotes, heavy dose of suppression uterine smooth muscle; Water decoction has sedation to animal central nervous systems, and has obvious and lasting hypotensive effect; The absorption of fracture local hematoma can be accelerated, promote callus formation; There is the effect of vitamin antagonist E shortage; Multiple bacillus can be suppressed; There are antihistaminic and choleretic effect.
Fructus Toosendan: bitter, cold; Return liver, small intestinal, urinary bladder channel.Function cures mainly: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
Semen Euryales: sweet in the mouth, puckery, property is put down.Cure mainly rheumatic arthritis, back gonalgia.Invigorating the spleen and replenishing QI, strong will of refreshing oneself, makes people's normal hearing and eyesight.It is not hungry that clothes of a specified duration make people make light of one's life by commiting suicide.Can also whet the appetite and help gas and the kidney invigorating, control frequency of micturition, seminal emission, purulent leukorrhea.Make powder to eat, beneficial people.But children's unsuitable polyphagia, not strengthening the spleen stomach, be difficult to digestion.
Gypsum Fibrosum: natural dihydrate gypsum (CaSO42H2O) is also called Gypsum Fibrosum, through calcining, levigately obtains Gypsum Fibrosum preparata.Clearing away heat-fire, relieving restlessness is quenched the thirst, convergence granulation promoting (with Gypsum Fibrosum Preparatum).Gypsum Fibrosum is mainly used in apoplexy cold and heat, and heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, three burnt large heat, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, pharynx heat of panting, also can do bath soup.Cure the wound cold headache as split.Simmer tea with Herba Alii fistulosi, pain of decaptitating.Control sky capable fanatic, wind syndrome of head revolves, stimulating milk secretion, wipes tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Only Yangming Channel headache, fever with chills, day feeds hectic fever, and drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.From Compendium of Material Medica 1, syndrome for epidemic febrile disease edema caused by disorder of QI excess-heat.Normal and Rhizoma Anemarrhenae mutual reinforcement between is use, as Baihu Tang.For epidemic febrile disease intense heat in both QI and blood systems, Gao Refa speckle, the then normal and removing pathogenic heat from blood and toxic substance from the body such as Cornu rhinocerotis, Radix Scrophulariae medicine compatibility, with heat clearing away speckle removing, as Huaban Tang.2, for dyspnea and cough due to lung-heat, restlessness and thirst.Normal and Semen Armeniacae Amarum, Herba Ephedrae adapted, with clearing away and dispersing lung-heat, relieving cough and asthma, as MAXINGSHIGAN TANG.3, for the high Sheng of stomach-fire, headache, toothache, gingival swelling and pain.Normal with the compatibility such as the Rhizoma Anemarrhenae, Radix Achyranthis Bidentatae, bitterly slow with pathogenic fire purging, as yunü decoction.4, for eczema, skin infection is not held back after bursting, burn due to hot liquid or fire.Normal and the compatibility such as Cortex Phellodendri, Indigo Naturalis, outward in order to heat clearing away sore, granulation promoting.
Fructus Lycii: the liver and the kidney tonifying Chinese medicine, its color is scarlet, and its taste is fragrant and sweet.Modern medicine study confirms that it contains the nutritional labeling such as betanin, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, facilitation is had to hemopoietic function, can also the effect such as defying age, mutation, antitumor, anti-fatty liver and blood sugar lowering.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission.
Placenta Hominis: Gan Xian, temperature.There is QI invigorating, nourish blood, benefit essence effect.Cure mainly: the disease such as deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, be slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation." Mingyi Bielu " is recorded: treat heavy sensation of the body icteric sclera, rami cardiaci inferiores is full, asthenia exopathogenic heat, xerostomia excessive thirst, anti-nausea, and more flaccidity falls, and reinforcing YIN-essence benefit essence, during rapid digestion of food is adjusted, protects god, determine lung qi, settling five organs, makes us fertile strong." book on Chinese herbal medicine is newly organized " is recorded: Radix Ophiopogonis, the volt fire in eliminating the pathogens from the lung, the pathogenic heat in clearing stomach, the impairment caused by overstrain of reinforcing the heart gas, the vomiting of hemostasis man, the smart reinforcing YIN-essence of benefit, separates tired quenching the thirst, U.S. color, happy skin, reducing the asthenic fever, separates the dryness of the lung, fixed cough, and what very can hold is monarch and making also for minister of can borrowing.But the magical effect of common people unknown Radix Ophiopogonis, often few use and can not be successfully unfortunate also.Do not know that Radix Ophiopogonis must be multiplex, strength begins large, and Gai Huofu is in lung, and sparkle liquid in doing, more than Radix Ophiopogonis, then fire can not be made; Heat is vehement in stomach, and endure its moon to the greatest extent, more than Radix Ophiopogonis, then fire can not cease.More have the fire of bladder, superinverse is in ambition, and urine drop can not go out, and people thinks that urine fire closes, due to bladder heat also, do not imitate with the medicine of water flowing, do not imitate with the agent of pathogenic fire reducing, this again what with? the gas of lid bladder, must the respectful clearly order row of the part of the body cavity above the diaphragm housing the heart and lungs, and fire is decline, and water is lower logical.The respectful clearly order of husband's part of the body cavity above the diaphragm housing the heart and lungs is reported in lung also, and heat of the lung, then making that lung is respectful is clearly not all right, and bladder fire closes, and water also closes.Therefore for logical bladder person, must the gas of lung heat clearing gold, the medicine of lung heat clearing is a lot of, all damages unhelpful, if eventually not Radix Ophiopogonis clear in have benefit, the fire of bladder can be rushed down, and don't damage the gas of bladder, but few with it, also can not be successful, lid abnormal smells from the patient Radix Ophiopogonis is flat cold, must be multiplex and the beginning has Ji also.
Flos Bombacis Malabarici: sweet; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.Master has loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema.
Retinervus Luffae Fructus: sweet is flat.Return lung, stomach, Liver Channel.Function cures mainly: dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.
Radix Glycyrrhizae: property is put down, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Medicine of the present invention also comprises: Cortex Hibisci, Flos Moutan, Litsea chenii, Herba Verbenae and Herba Malvastri Coromandeliani.
Cortex Hibisci: sweet, tepor.Function cures mainly: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis is controlled in external, tinea pedis.
Flos Moutan: bitter; Light; Flat.Return Liver Channel, function cures mainly: promoting blood flow to regulate menstruation.Main menoxenia; Abdominal pain during menstruation.
Litsea chenii: pungent; Bitter; Temperature.Return spleen; Stomach warp.Function cures mainly: circulation of qi promoting; Invigorating the stomach and promoting digestion.Main dyspepsia; Abdominal distention.
Herba Verbenae: the medicine being originally removing heat from blood removing blood stasis.Bottom abscess person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear.2. " not Lu ": main bottom abscess.3. supplement to the Herbal: primary symptom addiction blood addiction, chronic malaria, removing blood stasis.Decoct as sugar, wine takes.4. " Japan hanako materia medica ": logical menstruation, control married woman's vim and vigour tripe swollen, the moon waits irregular.5. " Amplification on Materia Medica addendum ": control incised wound, promoting the circulation of blood, 6. " detailed outlines " of invigorating blood circulation: smash and be coated with carbuncle and earwig urine skin ulcer, man's swelling of the vulva.7. " the SHENGCAO property of medicine is standby to be wanted ": promoting blood circulation to restore menstrual flow.Septicopyemia can be removed, wash hemorrhoid poison, move back top fire, reason traumatic injury.8. " classify herbal ": go urine stranguria with blood to swell and ache.9. " Tian Bao book on Chinese herbal medicine ": diuresis, suppressing the hyperactive liver pathogenic fire purging.Control red skin ulcer, acute catarrhal conjunctivitis.10. " modern Practical Chinese medicinal ": root is used for dysentery, chronic malaria, edema, tympanites etc.And have discharge function.
Herba Malvastri Coromandeliani: sweet, light, cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances dissipating blood stasis.For enteritis of catching a cold, dysentery, icterohepatitis, rheumatic arthritis; Traumatic injury is controlled in external, furuncle, carbuncle.
Embodiment 1 medicine 1
The embodiment of the present invention 1 provides a kind of medicine being used for the treatment of Chicken salpingitis, and medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion and Radix Glycyrrhizae 16 weight portion.
The preparation method of the medicine of the embodiment of the present invention comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 3 hours, and the amount of the water added and the mass ratio of mixture are 7:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6:1, and decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.20;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 3:1;
6th step, at room temperature will leave standstill 12h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, obtain drug powder.
The using method of embodiment of the present invention medicine: be mixed in feedstuff by medicine according to the percentage by weight of feedstuff 2-5%, conveniently feed mode is fed.
Embodiment 2 medicine 2
The embodiment of the present invention 2 provides a kind of medicine being used for the treatment of Chicken salpingitis, medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion, Radix Glycyrrhizae 16 weight portion, Cortex Hibisci 13 weight portion, Flos Moutan 12 weight portion, Litsea chenii 17 weight portion, Herba Verbenae 16 weight portion and Herba Malvastri Coromandeliani 19 weight portion.
The preparation method of the medicine of the embodiment of the present invention comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 4 hours, and the amount of the water added and the mass ratio of mixture are 8:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, the medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 7:1, and decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 2:1;
6th step, at room temperature will leave standstill 18h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, obtain drug powder.
The using method of embodiment of the present invention medicine: be mixed in feedstuff by medicine according to the percentage by weight of feedstuff 2-5%, conveniently feed mode is fed.
Toxicity test
1, acute toxicity test
Require to carry out prerun according to acute toxicity test, find that test medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get above-mentioned mice 40, fasting can't help water after 12 hours, administration group and water matched group is divided at random by body weight, often organize 20, administration group gives the medicinal liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the medicine prepared containing embodiment 1, gavage one day 2 times, make dosage in a day reach symphysis dose 192.0g/kg, water matched group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, equal Continuous Observation seven days, the toxic reaction that record may occur and death condition, after administration, mice outward appearance hair color light, behavioral activity is normal, pathologic neural reflex without exception occurs, in seven days, feed is good, and other Novel presentation is seen at end, body weight change no significant difference and none animal dead compared with water matched group, the main organs such as the perusal heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, the test result of result as embodiment 1 medicine is identical.
2, long term toxicity test
The medicine of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, the test result of result as embodiment 1 medicine is identical.
Clinical trial
(1) laboratory animal
During in January, 2012-October, in Shandong, chicken plant tests, and selects the laying hen 2200 suffering from Chicken salpingitis only as subjects.The symptom of ill chicken is: pain is uneasy, often with bloodstain on its eggshell of the egg of output, in fallopian tube, often discharge Huang, white pus sample secretions, pollute perianal and feather below thereof, to lay eggs difficulty, egg production declines, and good egg rate reduces, and the person of being in a bad way also there will be heating, stand transfixed to the ground, two wings are sagging, and disorderly, some abdominal paries lean on the symptom of ground or lethargy to feather pine.
(2) test method
Using wherein 900 ill chickens as this experiment for examination animal, be divided into three groups at random, often organize 300, adopt the medicine (embodiment group 1) of the embodiment of the present invention 1, the medicine (embodiment group 2) of embodiment 2 and conventional medicament to treat respectively.Wherein, medicine is mixed in feedstuff according to the percentage by weight of feedstuff 3% by embodiment group 1, and conveniently feed mode is fed; Medicine is mixed in feedstuff according to the percentage by weight of feedstuff 3% by embodiment group 2, and conveniently feed mode is fed; Conventional medicament is selected: ovum health (100g is watered 2000 jin) jin is drunk water, and spice after the mixing of egg fowl many ovum element+Bai Yang egg good fortune, conveniently feed mode is fed.Test period is 5 days, records the day egg production often organizing ill chicken respectively before experiment and after treatment.
(3) efficacy determination
Egg production becomes reconciled the recovery of egg rate normally, and mental status is good, and feather is normal, and fallopian tube, without pussy discharge, is judged to cure; Egg production egg rate of becoming reconciled takes a turn for the better, and mental status is good, and fallopian tube, without pussy discharge, is judged to be effectively; Egg production egg rate of becoming reconciled does not change substantially, and fallopian tube still has pussy discharge, and it is invalid to be judged to be.Wherein, effective percentage is the percentage ratio that healing number and significant figure account for sum.
(4) therapeutic outcome
Therapeutic effect is as shown in table 1, from therapeutic effect, adopts medicine of the present invention to be more than 91% to the treated effect of Chicken salpingitis, higher than matched group.Experiment before and after often organize laying hen every day egg production and good egg rate synopsis as shown in table 2.
Table 1 therapeutic effect synopsis
From the data of table 1, compared with matched group, use the Drug therapy Chicken salpingitis of the embodiment of the present invention 1 and embodiment 2, there is evident in efficacy, that cure rate is high advantage; Find in long-term observation subsequently, embodiment group 1 and embodiment group 2 laying hen of curing again sickness rate is starkly lower than the chicken of matched group.
The synopsis of front and back egg production and good egg rate treated by table 2
From the data of table 2, the medicine of the embodiment of the present invention 1 and embodiment 2 improves the laying rate of ill chicken, in treatment Chicken salpingitis, have the high advantage of cure rate.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. be used for the treatment of the medicine of Chicken salpingitis, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion and Radix Glycyrrhizae 10-20 weight portion.
2. the medicine being used for the treatment of Chicken salpingitis according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion and Radix Glycyrrhizae 12-19 weight portion.
3. the medicine being used for the treatment of Chicken salpingitis according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion and Radix Glycyrrhizae 16 weight portion.
4. be used for the treatment of the medicine of Chicken salpingitis, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 20-30 weight portion, Radix Rehmanniae Preparata 10-20 weight portion, Herba Carlinae biebersteinii 10-20 weight portion, Fructus Litchi 15-24 weight portion, Rhizoma Nupharis Bornetii 10-20 weight portion, Rhizoma Chuanxiong 15-25 weight portion, Fructus Toosendan 10-20 weight portion, Semen Euryales 10-25 weight portion, Gypsum Fibrosum 10-15 weight portion, Fructus Lycii 20-30 weight portion, Placenta Hominis 10-25 weight portion, Radix Ophiopogonis 10-20 weight portion, Flos Bombacis Malabarici 10-20 weight portion, Retinervus Luffae Fructus 10-25 weight portion, Radix Glycyrrhizae 10-20 weight portion, Cortex Hibisci 10-15 weight portion, Flos Moutan 10-15 weight portion, Litsea chenii 15-20 weight portion, Herba Verbenae 15-20 weight portion and Herba Malvastri Coromandeliani 15-20 weight portion.
5. the medicine being used for the treatment of Chicken salpingitis according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 22-28 weight portion, Radix Rehmanniae Preparata 12-18 weight portion, Herba Carlinae biebersteinii 12-17 weight portion, Fructus Litchi 18-21 weight portion, Rhizoma Nupharis Bornetii 14-20 weight portion, Rhizoma Chuanxiong 19-23 weight portion, Fructus Toosendan 12-17 weight portion, Semen Euryales 14-21 weight portion, Gypsum Fibrosum 12-15 weight portion, Fructus Lycii 23-28 weight portion, Placenta Hominis 15-20 weight portion, Radix Ophiopogonis 15-20 weight portion, Flos Bombacis Malabarici 15-20 weight portion, Retinervus Luffae Fructus 15-20 weight portion, Radix Glycyrrhizae 12-19 weight portion, Cortex Hibisci 12-15 weight portion, Flos Moutan 10-13 weight portion, Litsea chenii 15-18 weight portion, Herba Verbenae 15-18 weight portion and Herba Malvastri Coromandeliani 18-20 weight portion.
6. the medicine being used for the treatment of Chicken salpingitis according to claim 4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Radix Codonopsis 26 weight portion, Radix Rehmanniae Preparata 15 weight portion, Herba Carlinae biebersteinii 14 weight portion, Fructus Litchi 19 weight portion, Rhizoma Nupharis Bornetii 17 weight portion, Rhizoma Chuanxiong 21 weight portion, Fructus Toosendan 14 weight portion, Semen Euryales 17 weight portion, Gypsum Fibrosum 14 weight portion, Fructus Lycii 25 weight portion, Placenta Hominis 17 weight portion, Radix Ophiopogonis 17 weight portion, Flos Bombacis Malabarici 18 weight portion, Retinervus Luffae Fructus 17 weight portion, Radix Glycyrrhizae 16 weight portion, Cortex Hibisci 13 weight portion, Flos Moutan 12 weight portion, Litsea chenii 17 weight portion, Herba Verbenae 16 weight portion and Herba Malvastri Coromandeliani 19 weight portion.
7. the preparation method being used for the treatment of the medicine of Chicken salpingitis as described in any one of claim 1-6, is characterized in that, described preparation method comprises:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 2 ~ 3:1;
6th step, at room temperature will leave standstill 12 ~ 24h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, and concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, obtain drug powder.
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CN106039137A (en) * 2016-05-30 2016-10-26 宿州天雨养殖(集团)有限公司 Medicine for treating salpingitis in egg-laying poultry
CN108567875A (en) * 2018-07-16 2018-09-25 李焱焱 A kind of Chinese medicine composition and its Chinese medicine preparation for treating salpingitis of layer chicken
CN108771754B (en) * 2018-08-02 2021-03-02 河南牧翔动物药业有限公司 Traditional Chinese medicine composition for treating salpingitis of laying hens in middle and later periods and preparation method thereof

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