CN104740068A - Traditional Chinese medicine for treating accumulated damp heat chronic pelvic inflammation and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating accumulated damp heat chronic pelvic inflammation and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw herbal materials: common nepenthes, Malvastrum coromandelianum, phoenix-tail fern, Roots of Gossampinus malabaria, Serissa serissoides, hypericum japonicum, Amaranthus lividus, creeping oxalis, capitate knotweed herb, Solanum Vine, abrus cantoniensis hance, emilia prenanthoides, Antenoron filiforme, leaf of shrubby baeckea, Hygrophila salicifolia, atalantia buxifolia, cryptotaenia japonica and peach grass. The traditional Chinese medicine has a specific effect for treating the accumulated damp heat chronic pelvic inflammation, has a small toxic side effect and is low in relapse possibility.

Description

A kind of Chinese medicine and preparation method for the treatment of Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease.

Background technology

Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, there is the touching feature not healing, be easy to recurrence, it is not thorough to be that a great problem chronic pelvic inflammatory disease in domestic and international gyniatrics mostly is acute pelvic inflammatory disease treatment, patient meets flu, overwork etc. causes premunition low, source of disease bacterium is active again causes pelvic inflammation recurrence, also there is some patients and NAI history, because onset is slow, ignore caused by treatment.

Western medical treatment chronic pelvic inflammatory disease is based on antibiotic therapy, though there is certain curative effect, often poor effect, and have certain toxic and side effects, also may cause bacterial drug resistance, bring larger difficulty to treatment.

Chronic pelvic inflammatory disease belongs to the category such as motherland's medical science " lower abdominal pain ", " leukorrheal diseases ", " lump in the abdomen ", " metrorrhagia ".Motherland's medical science thinks that this disease is many by hollow through row vessels of the uterus in puerperal, invades uterus in affection of exogenous damp pyretic toxicity; Or spleen is suffered from a deficiency of the kidney damage, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, cause pelvic cavity viscera inner membrance QI-blood circulation not smooth, damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Control or wrong treatment owing to losing, cause recurrent exerbation, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, Chinese medicine of the present invention has definite curative effect to Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, and toxic and side effects is little, not easily recurs.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, its raw medicinal material comprises: Herba nepenthis, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Radix Gossampini, Radix Serissae, Herba Hyperici Japonici, Herba amaranthi ascendentis, Herba Oxalidis Corniculatae, Herba Polygoni Capitati, Herba Solani Lyrati, Herba Abri, Radix seu Folium Alchorneae trewioidis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Folium Baeckeae, Hygrophila salicifolia, Folium desmoris, Caulis et folium cryptotaeniae japonicae and purslane speedwell Herba.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba nepenthis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Pteridis Multifidae 10 ~ 20 parts, Radix Gossampini 10 ~ 20 parts, Radix Serissae 15 ~ 25 parts, Herba Hyperici Japonici 30 ~ 40 parts, Herba amaranthi ascendentis 5 ~ 15 parts, Herba Oxalidis Corniculatae 15 ~ 25 parts, Herba Polygoni Capitati 40 ~ 50 parts, Herba Solani Lyrati 5 ~ 15 parts, Herba Abri 20 ~ 30 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Folium Baeckeae 15 ~ 25 parts, Hygrophila salicifolia 30 ~ 40 parts, Folium desmoris 5 ~ 15 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 25 parts and purslane speedwell Herba 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba nepenthis 10 ~ 15 parts, Herba Malvastri Coromandeliani 20 ~ 25 parts, Herba Pteridis Multifidae 10 ~ 15 parts, Radix Gossampini 10 ~ 15 parts, Radix Serissae 15 ~ 20 parts, Herba Hyperici Japonici 30 ~ 35 parts, Herba amaranthi ascendentis 5 ~ 10 parts, Herba Oxalidis Corniculatae 15 ~ 20 parts, Herba Polygoni Capitati 40 ~ 45 parts, Herba Solani Lyrati 5 ~ 10 parts, Herba Abri 20 ~ 25 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Folium Baeckeae 15 ~ 20 parts, Hygrophila salicifolia 30 ~ 35 parts, Folium desmoris 5 ~ 10 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 20 parts and purslane speedwell Herba 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba nepenthis 13 parts, Herba Malvastri Coromandeliani 24 parts, Herba Pteridis Multifidae 11 parts, Radix Gossampini 14 parts, Radix Serissae 16 parts, Herba Hyperici Japonici 33 parts, Herba amaranthi ascendentis 8 parts, Herba Oxalidis Corniculatae 18 parts, Herba Polygoni Capitati 44 parts, Herba Solani Lyrati 6 parts, Herba Abri 22 parts, Radix seu Folium Alchorneae trewioidis 7 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, Folium Baeckeae 18 parts, Hygrophila salicifolia 31 parts, Folium desmoris 9 parts, Caulis et folium cryptotaeniae japonicae 17 parts and purslane speedwell Herba 22 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, and toxic and side effects is little, not easily recurs.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, its raw medicinal material comprises: Herba nepenthis, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Radix Gossampini, Radix Serissae, Herba Hyperici Japonici, Herba amaranthi ascendentis, Herba Oxalidis Corniculatae, Herba Polygoni Capitati, Herba Solani Lyrati, Herba Abri, Radix seu Folium Alchorneae trewioidis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Folium Baeckeae, Hygrophila salicifolia, Folium desmoris, Caulis et folium cryptotaeniae japonicae and purslane speedwell Herba.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba nepenthis: [source] is the stem and leaf of Nepenthaceae plant Herba nepenthis.[nature and flavor] are sweet, light, cool.[return through] returns lung, gallbladder, stomach warp.[function cures mainly] nourishing the lung to arrest cough, clearing away heat-damp and promoting diuresis calculus, removing toxic substances and promoting subsidence of swelling.Main dryness of the lung hemoptysis, cold cough, pertussis, jaundice, dysentery, lithangiuria, gastric and duodenal ulcers, hypertension, diabetes, skin infection carbuncle.

Herba Malvastri Coromandeliani: [source] is the herb of Malvaceae plant Herba Malvastri Coromandeliani.[nature and flavor] are micro-sweet, cool.[return through] returns lung, liver, large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main damp-heat dysentery, jaundice, cough due to lung-heat, laryngopharynx swelling and pain, hemorrhoid, carbuncle sore tumefacting virus, traumatic injury, prostatitis.

Herba Pteridis Multifidae: the herb that [source] is Pteridaceae plant Herba Pteridis Multifidae or root.[nature and flavor] are light, micro-hardship, cold.[return through] returns large intestine, the heart, Liver Channel [function cures mainly] clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating.Main dysentery, has loose bowels, stranguria with turbid discharge, leukorrhagia, jaundice, furuncle swelling toxin, sore throat tonsillitis, lymphoid tuberculosis, parotitis, mastitis, high fever tic, snake bite and insect sting, and spit blood, epistaxis, hematuria, has blood in stool, traumatic hemorrhage.

Radix Gossampini: the root that [source] is Bombacaceae plant kapok or root bark.[nature and flavor] mildly bitter flavor, cool in nature.[return through] returns spleen, stomach warp.[function cures mainly] expelling wind and removing dampness, heat-clearing and toxic substances removing, removing obstruction for relieving pain.Main air pain of dampness syndrome, stomachache, bloody dysentery, puerperal edema, scrofula, osteopatia sprain.

Radix Serissae: the herb that [source] is Maguireothamnus speciosus Radix Serissae or Serissa foetida.[nature and flavor] are bitter, pungent, cool.[return through] returns liver, spleen channel.[function cures mainly] dispels the wind, dampness removing, heat clearing away, removing toxic substances.Main flu, icterohepatitis, oedema due to nephritis, cough, laryngalgia, keratitis, enteritis, dysentery, lumbago and skelalgia, hemoptysis, hematuria, women's amenorrhea, leucorrhea, infantile malnutrition, infantile convulsion, acute toothache, swollen ulcer drug, traumatic injury.

Herba Hyperici Japonici: [source] is the herb of Hypericaceae plant Herba Hyperici Japonici.[nature and flavor] are sweet, micro-hardship, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.

Herba amaranthi ascendentis: the herb that [source] is the recessed head Herba Amaranthi tricoloris of amaranthaceous plant and Amaranthus retroflexus or root.[nature and flavor] are sweet, are slightly cold.[return through] returns large intestine, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, diuresis.Main dysentery, diarrhoea, furuncle swelling toxin, venom, bee sting, dysuria, edema.

Herba Oxalidis Corniculatae: [source] is the oxalic herb of Oxalidaceae plant.[nature and flavor] acid, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, subduing swelling and detoxicating.Control and have loose bowels, dysentery, jaundice, gonorrhea, leucorrhea with red and white discharge, measles, spit blood, epistaxis, laryngopharynx swelling and pain, furuncle, carbuncle, scabies, hemorrhoid, proctoptosis, traumatic injury, burn.

Herba Polygoni Capitati: [source] is the herb of polygonaceae plant Herba Polygoni Capitati.[nature and flavor] are bitter, pungent, cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.Main dysentery, pyelonephritis, cystitis, lithangiuria, rheumatalgia, traumatic injury, mumps, skin infection, eczema.

Herba Solani Lyrati: [source] is the herb of plant of Solanaceae Herba Solani Lyrati.[nature and flavor] sweet in the mouth is bitter, cold in nature.[return through] returns liver, gallbladder, kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat, cholecystitis, cholelithiasis, oedema due to nephritis, rheumatic arthritis, women's damp-heat vaginal discharge, infantile hyperpyrexia is frightened jerks, carbuncle scrofula, eczema pruritus, herpes zoster.

Herba Abri: [source] is the herb of leguminous plant Guangdong Semen Abri Precatorii.[nature and flavor] are sweet, bitter, cool.[return through] GUIXIN, lung, liver, stomach, kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury becomes silted up bitterly, acute mastitis.

Radix seu Folium Alchorneae trewioidis: the root that [source] is the red back of the body Cortex Alchorneae Davidii of euphorbia plant and leaf.[nature and flavor] are sweet, cool.[return through] returns bladder, large intestine, lung meridian.[function cures mainly] clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, killing parasites for relieving itching.Main dysentery, pyretic stranguria, stranguria caused by urinary stone, hematuria, metrorrhagia, leukorrhagia, rubella, eczema, scabies, malaria, caries pain, decubital ulcer.

Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): [source] is polygonaceae plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), the herb of undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).[nature and flavor] are pungent, bitter, cool in nature.[function cures mainly] cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main hemoptysis, spit blood, have blood in stool, metrorrhagia, has loose bowels, dysentery, stomachache, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury, rheumatic arthralgia, scrofula, carbuncle.

Folium Baeckeae: [source] is the branch and leaf of myrtle Folium Baeckeae.[nature and flavor] bitter in the mouth, pungent, cool in nature.[function cures mainly] blood-activating analgetic, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, killing parasites for relieving itching.Main traumatic injury, liver cirrhosis, has loose bowels, pyretic stranguria, dysuria, pudendal pruritus, beriberi, eczema, skin pruritus, scabies, burn due to hot liquid or fire, worm venom.

Hygrophila salicifolia: [source] is the herb of acanthaceous plant Hygrophila salicifolia.[nature and flavor] are sweet, micro-hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, blood-activating analgetic.For pharyngolaryngitis, mastitis, spit blood, epistaxis, pertussis; Fracture is controlled in external, traumatic injury, venom.

Folium desmoris: [source] is the leaf of annonaceae plant Desmos chinensis.[nature and flavor] acrid in the mouth is bitter, warm in nature.[return through] returns spleen, Liver Channel.[function cures mainly] expelling wind and removing dampness, blood-activating analgetic, invigorating the spleen and regulating the stomach, preventing the attack (or recurrence) of malaria parasite killing.Main rheumatic ostalgia, malaria, edema, traumatic injury, rubella, scabies, rotten foot.

Caulis et folium cryptotaeniae japonicae: [source] is the stem and leaf of samphire Caulis et folium cryptotaeniae japonicae.[nature and flavor] acrid in the mouth, bitter, property is put down.[function cures mainly] dispelling wind stopping cough, eliminating damp, detoxifying, blood-activating analgetic.Main cold cough, lung abscess, drenches pain, hernia, menoxenia, acute toothache, cataract, and carbuncle skin ulcer swells, skin pruritus, treating swelling and pain by traumatic injury, snake bite and insect sting.

Purslane speedwell Herba: [source] is the herb of goatweed grave Herba Linderniae Crustaceae band insect gall.[nature and flavor] sweet in the mouth, micro-pungent, property is put down.[return through] returns liver, stomach, lung meridian.[function cures mainly] removing stasis to stop bleeding, clearing heat for detumescence, pain relieving.Main traumatic injury, laryngopharynx swelling and pain, ulcer sores, hemoptysis, spits blood, epistaxis, stomachache due to hyperactive liver-QI attacking the stomach, colicky, dysmenorrhea.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba nepenthis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Pteridis Multifidae 10 ~ 20 parts, Radix Gossampini 10 ~ 20 parts, Radix Serissae 15 ~ 25 parts, Herba Hyperici Japonici 30 ~ 40 parts, Herba amaranthi ascendentis 5 ~ 15 parts, Herba Oxalidis Corniculatae 15 ~ 25 parts, Herba Polygoni Capitati 40 ~ 50 parts, Herba Solani Lyrati 5 ~ 15 parts, Herba Abri 20 ~ 30 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Folium Baeckeae 15 ~ 25 parts, Hygrophila salicifolia 30 ~ 40 parts, Folium desmoris 5 ~ 15 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 25 parts and purslane speedwell Herba 20 ~ 30 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba nepenthis 10 ~ 15 parts, Herba Malvastri Coromandeliani 20 ~ 25 parts, Herba Pteridis Multifidae 10 ~ 15 parts, Radix Gossampini 10 ~ 15 parts, Radix Serissae 15 ~ 20 parts, Herba Hyperici Japonici 30 ~ 35 parts, Herba amaranthi ascendentis 5 ~ 10 parts, Herba Oxalidis Corniculatae 15 ~ 20 parts, Herba Polygoni Capitati 40 ~ 45 parts, Herba Solani Lyrati 5 ~ 10 parts, Herba Abri 20 ~ 25 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Folium Baeckeae 15 ~ 20 parts, Hygrophila salicifolia 30 ~ 35 parts, Folium desmoris 5 ~ 10 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 20 parts and purslane speedwell Herba 20 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba nepenthis 13 parts, Herba Malvastri Coromandeliani 24 parts, Herba Pteridis Multifidae 11 parts, Radix Gossampini 14 parts, Radix Serissae 16 parts, Herba Hyperici Japonici 33 parts, Herba amaranthi ascendentis 8 parts, Herba Oxalidis Corniculatae 18 parts, Herba Polygoni Capitati 44 parts, Herba Solani Lyrati 6 parts, Herba Abri 22 parts, Radix seu Folium Alchorneae trewioidis 7 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, Folium Baeckeae 18 parts, Hygrophila salicifolia 31 parts, Folium desmoris 9 parts, Caulis et folium cryptotaeniae japonicae 17 parts and purslane speedwell Herba 22 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1 capsule

Get Herba nepenthis 130g, Herba Malvastri Coromandeliani 240g, Herba Pteridis Multifidae 110g, Radix Gossampini 140g, Radix Serissae 160g, Herba Hyperici Japonici 330g, Herba amaranthi ascendentis 80g, Herba Oxalidis Corniculatae 180g, Herba Polygoni Capitati 440g, Herba Solani Lyrati 60g, Herba Abri 220g, Radix seu Folium Alchorneae trewioidis 70g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 60g, Folium Baeckeae 180g, Hygrophila salicifolia 310g, Folium desmoris 90g, Caulis et folium cryptotaeniae japonicae 170g and purslane speedwell Herba 220g;

Prepare according to the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 70%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.3 times, the magnesium stearate of 0.02 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is incapsulated in housing, namely obtain capsule finished product.

Embodiment 2 powder

Get Herba nepenthis 110g, Herba Malvastri Coromandeliani 220g, Herba Pteridis Multifidae 140g, Radix Gossampini 130g, Radix Serissae 190g, Herba Hyperici Japonici 310g, Herba amaranthi ascendentis 50g, Herba Oxalidis Corniculatae 200g, Herba Polygoni Capitati 420g, Herba Solani Lyrati 90g, Herba Abri 250g, Radix seu Folium Alchorneae trewioidis 90g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 80g, Folium Baeckeae 170g, Hygrophila salicifolia 350g, Folium desmoris 70g, Caulis et folium cryptotaeniae japonicae 160g and purslane speedwell Herba 240g;

Prepare according to the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 80%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 100 object micropowders;

3rd step: add the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains powder.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 30-40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>42.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 606 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 105 routine cases are my Out-patient Department patient of in February, 2011 ~ in December, 2013.All patients all meet the diagnostic criteria about chronic pelvic inflammatory disease in " obstetrics and gynecology ".Patient is divided into treatment group and matched group at random, wherein treatment group 55 people, 22 ~ 52 years old age, average (29.5 ± 6.3) year, the course of disease: 3 months ~ 7 years, average (2.9 ± 1.6) year; Matched group 50 people, 23 ~ 50 years old age, average (28.8 ± 5.9) year, the course of disease: 4 months ~ 8 years, average (3.1 ± 1.8) year.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: all cases are all with reference to the diagnostic criteria of sixth version " obstetrics and gynecology " about chronic pelvic inflammatory disease.(1) symptom: hypogastric region falling inflation pain, lumbosacral region is ached, menoxenia, leucorrhoea grow in quantity or in purulence.(2) sign: uterus is many in rear position, limitation of activity; Adnexa thickens, tenderness, hardening, sometimes can touch enclosed mass.(3) ultrasound diagnosis: inflammatory mass, pelvic hydrops, hydrosalpinx etc.

Get rid of the optimum or malignant tumor of tubo-ovarian cyst, pelvic cavity inner tissue, and the important organ disease such as heart and brain Liver and kidney.

Chinese medical discrimination:

Accumulation of Dampness Heat and Blood Stasis type: disease sees lower abdomen dull pain, or pain with tenderness, pain connect waist sacrum, low thermal fluctuation, through row or tired time increase the weight of, profuse leukorrhea, yellow skin, matter thickness, uncomfortable in chest indigestion and loss of appetite, xerostomia is not for drink, and large loose stool or constipated; yellow urine, corpulent tongue is large, and color is red, yellow and greasy fur, wiry and frequent pulse or sliding number.

Therapeutic Method:

Matched group: intravenous drip levofloxacin 0.5g, metronidazole glucose 0.5g, every day 1 time 15 days is 1 course for the treatment of.

Treatment group: oral each 5 of Chinese medicine embodiment 1 capsule of the present invention, every day 3 times.It within 15 days, is 1 course for the treatment of.

Two groups of patients except the hot person of height adopts antipyretic suit the medicine to the illness except, all do not use other medicines.

Curative effect judging standard: evaluate curative effect with reference to " new Chinese medicine guideline of clinical investigations ".Cure: clinical symptoms, sign disappear completely or ultrasound diagnosis uterus adnexa normal, pelvic cavity without enclosed mass, without hydrops or fallopian tube inspection unobstructed.Effective: subjective symptoms is clearly better or substantially disappears, gynaecological examination or B ultrasonic point out pelvic cavity symptom, sign is obviously improved.Effective: subjective symptoms takes a turn for the better, gynaecological examination or B ultrasonic point out pelvic cavity symptom, sign is all improved.Invalid: sings and symptoms is without improvement, and B ultrasonic prompting pelvic cavity symptom, sign are without improvement.

Therapeutic outcome:

After 2 courses for the treatment of of two groups of patient treatments, effect is as follows:

Group	n	Cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	55	25	15	9	6	49(89.09％)
Matched group	50	14	12	10	14	36(72.00％)

Note: compare P<0.05 with matched group

Relapse rate compares:

Choose healing and effective case, carry out following up a case by regular visits to of 1 year to two groups of patients, in follow-up period, matched group has 6 example recurrences, and relapse rate is 23.08% (6/26), and treatment group has 1 example recurrence, and relapse rate is 2.5% (1/40).Treatment group relapse rate is starkly lower than matched group.Difference has statistical significance (P<0.01).

Concrete case: Chen, 31 years old.Lower abdomen dull pain, pain connect waist sacrum, through row or tired time increase the weight of, profuse leukorrhea, yellow skin, matter thickness, adnexa thickens, tenderness, hardening, and inflammatory mass is shown in ultrasound diagnosis, pelvic hydrops.Constipation, yellow urine, corpulent tongue is large, and color is red, yellow and greasy fur, and wiry and frequent pulse is diagnosed as chronic pelvic inflammatory disease, and TCM Syndrome Type is Accumulation of Dampness Heat and Blood Stasis type.Giving each 5 of Chinese medicine embodiment 1 capsule of the present invention, every day 3 times, 15 days was 1 course for the treatment of.Treat 2 courses for the treatment of, cure.Follow up a case by regular visits to and do not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat a Chinese medicine for Accumulation of Dampness Heat and Blood Stasis type chronic pelvic inflammatory disease, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba nepenthis, Herba Malvastri Coromandeliani, Herba Pteridis Multifidae, Radix Gossampini, Radix Serissae, Herba Hyperici Japonici, Herba amaranthi ascendentis, Herba Oxalidis Corniculatae, Herba Polygoni Capitati, Herba Solani Lyrati, Herba Abri, Radix seu Folium Alchorneae trewioidis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Folium Baeckeae, Hygrophila salicifolia, Folium desmoris, Caulis et folium cryptotaeniae japonicae and purslane speedwell Herba.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba nepenthis 10 ~ 20 parts, Herba Malvastri Coromandeliani 20 ~ 30 parts, Herba Pteridis Multifidae 10 ~ 20 parts, Radix Gossampini 10 ~ 20 parts, Radix Serissae 15 ~ 25 parts, Herba Hyperici Japonici 30 ~ 40 parts, Herba amaranthi ascendentis 5 ~ 15 parts, Herba Oxalidis Corniculatae 15 ~ 25 parts, Herba Polygoni Capitati 40 ~ 50 parts, Herba Solani Lyrati 5 ~ 15 parts, Herba Abri 20 ~ 30 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 15 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, Folium Baeckeae 15 ~ 25 parts, Hygrophila salicifolia 30 ~ 40 parts, Folium desmoris 5 ~ 15 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 25 parts and purslane speedwell Herba 20 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba nepenthis 10 ~ 15 parts, Herba Malvastri Coromandeliani 20 ~ 25 parts, Herba Pteridis Multifidae 10 ~ 15 parts, Radix Gossampini 10 ~ 15 parts, Radix Serissae 15 ~ 20 parts, Herba Hyperici Japonici 30 ~ 35 parts, Herba amaranthi ascendentis 5 ~ 10 parts, Herba Oxalidis Corniculatae 15 ~ 20 parts, Herba Polygoni Capitati 40 ~ 45 parts, Herba Solani Lyrati 5 ~ 10 parts, Herba Abri 20 ~ 25 parts, Radix seu Folium Alchorneae trewioidis 5 ~ 10 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, Folium Baeckeae 15 ~ 20 parts, Hygrophila salicifolia 30 ~ 35 parts, Folium desmoris 5 ~ 10 parts, Caulis et folium cryptotaeniae japonicae 15 ~ 20 parts and purslane speedwell Herba 20 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba nepenthis 13 parts, Herba Malvastri Coromandeliani 24 parts, Herba Pteridis Multifidae 11 parts, Radix Gossampini 14 parts, Radix Serissae 16 parts, Herba Hyperici Japonici 33 parts, Herba amaranthi ascendentis 8 parts, Herba Oxalidis Corniculatae 18 parts, Herba Polygoni Capitati 44 parts, Herba Solani Lyrati 6 parts, Herba Abri 22 parts, Radix seu Folium Alchorneae trewioidis 7 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 6 parts, Folium Baeckeae 18 parts, Hygrophila salicifolia 31 parts, Folium desmoris 9 parts, Caulis et folium cryptotaeniae japonicae 17 parts and purslane speedwell Herba 22 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.

7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 4 ~ 6 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;

3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.2 ~ 0.4 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.

8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 70 ~ 80%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 70 ~ 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 3 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 3 ~ 5 times in the micropowders obtained by second step, mixing, obtains powder.