CN103301388B - Traditional Chinese medicine composition for treating chronic gastrointestinal inflammation - Google Patents

Abstract

The invention aims at providing a traditional Chinese medicine composition for treating chronic gastrointestinal inflammation. The traditional Chinese medicine composition is prepared by repeated verification of a clinical test, and accords with the principle of the traditional Chinese medicine. The traditional Chinese medicine disclosed by the invention is started from dual health-care effects of nourishing the stomach and expanding the bowel, has the functions of clearing away heat and eliminating dampness, regulating flow of vital energy and relieving diarrhea, helping digestion, and relaxing the bowels and large intestines, has unique curative effects on various gastrointestinal diseases, has an incomparable magical effect of the modern medicine, and fundamentally removes the pain of a sufferer. The traditional Chinese medicine composition is characterized by being prepared from the following materials of fructus aurantii, caulis akebiae, myrobalan, peach kernel, flos sophorae, semen cannabis, atlas leaf, black false hellebore, agastache rugosus, raphanus sativus L, fructus amomi, anisodus luridus, conespike flemingia root, tonkin pepper herb, twocolor magnoliavine root and stem, rhizoma galangae, elecampane, ginseng flower, herba portulacae and root of three-nerved spicebush.

Description

A kind of Chinese medicine composition for the treatment of chronic gastrointestinal inflammation

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of chronic gastrointestinal inflammation.

Background technology

Chronic gastroenteritis is gastric mucosa and intestinal mucosa inflammation.Modal is chronic superficial gastritis and chronic atrophic gastritis.Its main clinical manifestation is loss of appetite, epigastric discomfort and dull pain, belch, pantothenic acid, Nausea and vomiting etc.

Constipation is more common.Feces amount is few, difficult defecation, 1-2 time weekly, occasionally has one time, more than ten sky person, thus often uses cathartic.Sometimes because anal sphincter shrinks, stool is in pencil sample fine strip shape.The symptom diarrhoea of chronic gastroenteritis: every day 1 time or repeatedly.What have only early breaks out repeatedly defecation after meal, and without diarrhoea, can occasionally there be diarrhoea on the 1st more than 20 persons all the other times.Diarrhoea does not occur in night, and can not awaken because of defecate feeling, so do not disturb sleep, also faecal incontinence not occur, with a large amount of white or transparent mucus in the feces of some patient, be mucus even entirely.In the diarrhoea course of disease, often can there is the normal or constipation of the defecation in a period, occur diarrhoea with normal just or the phenomenon that mutually replaces of constipation.

General treatment:

(1), active treatment pars oralis pharyngis focus of infection, the secretions that sputum, nasal mucus etc. do not carried disease germs is swallowed and is caused chronic gastritis into stomach.

(2), keep in high spirits: spirit depressing or hypertonicity and fatigue, easily cause sphincter of pylorus dysfunction, bile reflux and chronic gastritis occurs.

A. due to weakness of spleen and stomach: ferritic is insufficiency of the spleen, or eating and drinking without temperance, irregular diet, make taste injured and weak, shows as gastral cavilty feeling of fullness distending pain, inappetence, abdominal distention after meal, fatigue and weakness, treat with invigorating the spleen and regulating the stomach;

B. spleen-stomach deficiency-cold: insufficiency of the spleen heavier, spleen YANG deficiency, or voracious raw food, damage spleen sun, cause yin-cold excess, show as vague epigastralgia, gain happily temperature by, after meal alleviation of pain, pain of empty stomach is heavy, extremity are chilly, controls with warming the spleen warming the stomach, relieving spasm to stop pain;

C. hyperactive liver-qi attacking the stomach: feelings will is not smooth, depressed rage impairing the liver, hyperactive liver-QI attacking the stomach, mechanism of qi blocks, abnormal ascending-descending of QI, shows as that stomach side of body distending pain, belch are frequent, alleviates after belch or aerofluxus, or feels oppressed with susceptible to lose temper due to restlessness, sighing frequently uncomfortable in chest, cervical region, pharyngeally has the symptoms such as foreign body sensation.Treatment is with depressed liver-energy dispersing and QI regulating and stomach and alleviating pain.

The modal symptom of primary disease is stomach pain and feeling of repletion, especially after the meal exacerbation of symptoms, and pleasant on an empty stomach.Though each food-intake is few, feel satiety and uncomfortable, often with the phenomenon such as belch, acid regurgitation, heartburn, nausea and vomiting, inappetence, dyspepsia.Due to feed less, dyspepsia, malnutrition can be produced, become thin, anemia and weakness.Some patients also with neurological symptom as psychentonia, mood agitation, insomnia, cardiopalmus, forgetful etc., these phenomenons conversely again can the stomach symptom of exacerbates chronic gastritis, forms vicious cycle, makes the state of an illness complicated, not easily cure.

Traditional Chinese medical herbal treatment is clinical conventional method, and its effect is also better, acts on traditional Chinese medical science taste and rules together, the theory of its WEINAIAN, can reach the object of healing.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic gastrointestinal inflammation, configured by clinic tests and repeated verification, meet the theory of Chinese medicine.Drug regimen of the present invention is started with from nourishing the stomach, wide intestinal double health effect, clearing away heat and eliminating dampness, antidiarrheal of regulating the flow of vital energy, be easy to digestion, tonneau large intestine has unique curative effect to various gastrointestinal disease, there is the unrivaled effect of modern medicines, fundamentally cure gastrointestinal inflammation, relieve the misery of patient.

Treat a Chinese medicine composition for chronic gastrointestinal inflammation, it is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 5-10 part, Caulis Akebiae 5-10 part, Fructus Chebulae 5-10 part, Semen Persicae 5-10 part, Flos Sophorae 5-10 part, Fructus Cannabis 1-6 part, Folium ailanthi 1-6 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1-6 part, Herba Pogostemonis 1-6 part, Radix Raphani 1-6 part, Fructus Amomi 0.1-0.9 part, Rhizoma Scopoliae Japonicae 0.1-0.9 part, Herba Moghaniae fruticulosa 0.1-0.9 part, Herba Piperris Tonkinensis 0.1-0.9 part, Radix Schisandrae Bicoloris 0.1-0.9 part, Rhizoma Alpiniae Officinarum 1-6 part, Radix Aucklandiae 1-6 part, Flos Ginseng 1-6 part, Herba Portulacae 1-6 part, Radix Linderae 1-6 part;

Preparation method:

By formula proportion, above-mentioned Chinese medicine ovendry power is broken into 300-400 object fine powder and uses ultrasound wave homogenize 10-30 minute at 0-10 DEG C of temperature, incapsulate after mix homogeneously and get product;

Instructions of taking: half an hour ante cibum takes with warm water, every day three times, each serving with 15g, warm water delivery service one month is a course for the treatment of, and 2-3 courses for the treatment of cure.To avoid cold and uncooked food the thing of pungent stimulation.

Treat a Chinese medicine composition for chronic gastrointestinal inflammation, it is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 6-9 part, Caulis Akebiae 6-9 part, Fructus Chebulae 6-9 part, Semen Persicae 6-9 part, Flos Sophorae 6-9 part, Fructus Cannabis 2-5 part, Folium ailanthi 2-5 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2-5 part, Herba Pogostemonis 2-5 part, Radix Raphani 2-5 part, Fructus Amomi 0.2-0.8 part, Rhizoma Scopoliae Japonicae 0.2-0.8 part, Herba Moghaniae fruticulosa 0.2-0.8 part, Herba Piperris Tonkinensis 0.2-0.8 part, Radix Schisandrae Bicoloris 0.2-0.8 part, Rhizoma Alpiniae Officinarum 2-5 part, Radix Aucklandiae 2-5 part, Flos Ginseng 2-5 part, Herba Portulacae 2-5 part, Radix Linderae 2-5 part.

Treat a Chinese medicine composition for chronic gastrointestinal inflammation, it is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 8 parts, Caulis Akebiae 8 parts, Fructus Chebulae 8 parts, 8 parts, Semen Persicae, 8 parts, Flos Sophorae, Fructus Cannabis 4 parts, Folium ailanthi 4 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 4 parts, Herba Pogostemonis 4 parts, Radix Raphani 4 parts, Fructus Amomi 0.5 part, Rhizoma Scopoliae Japonicae 0.5 part, Herba Moghaniae fruticulosa 0.5 part, Herba Piperris Tonkinensis 0.5 part, Radix Schisandrae Bicoloris 0.5 part, Rhizoma Alpiniae Officinarum 4 parts, the Radix Aucklandiae 4 parts, Flos Ginseng 4 parts, Herba Portulacae 4 parts, the Radix Linderae 4 parts.

the present invention relates to pharmacology and the property of medicine of Chinese medicine:

Fructus Aurantii:

[nature and flavor] are bitter; Acid; Cold nature

[return through]: lung; Spleen; Liver; Stomach; Large intestine channel

[function cures mainly]: chest and diaphragm feeling of fullness; Distending pain over the hypochondrium; Accumulation of food in the stomach and intes tine due to indigestion; Distension and fullness in the abdomen; Heavy after dysentery; Proctoptosis; Uterine prolapse.

Caulis Akebiae:

[nature and flavor] bitter, be slightly cold; Enter heart channel, small intestine meridian, urinary bladder channel.　　

[function cures mainly] clearing away heart-fire, diuresis, stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.　

Fructus Chebulae:

[meridian distribution of property and flavor] bitter in the mouth; Acid; Puckery; Property is put down.

[effect] astringes the lung; Astringing intestine to stop diarrhea; The therapeutic method to keep the adverse QI flowing downwards; Sore-throat relieving.

[curing mainly] chronic diarrhea; Chronic dysentery; Proctoptosis; To breath with cough phlegmatic cough; Chronic cough aphonia.

Semen Persicae:

Sweet flat, the bitter in the mouth of [meridian distribution of property and flavor] property, enters lung, liver, large intestine channel;

[function cures mainly] has blood stasis removing and clots absorbing, moisturizes effect of laxation; Control amenorrhea, dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, traumatic injury, dryness of the intestine constipation.

Flos Sophorae: nature and flavor with return through: bitter in the mouth, be slightly cold.Return liver, large intestine channel.Function with cure mainly: cooling blood for hemostasis, blood pressure lowering.For spitting blood, have blood in stool, bleeding hemorrhoids, hematuria metrorrhagia, hypertension.Suitable amount used externally.Many parch to black that stops blooding are used; The many raw use of expelling phlegm for arresting cough.

Fructus Cannabis:

[meridian distribution of property and flavor] sweet in the mouth, property is put down, and returns spleen, stomach, large intestine channel,

[effect] loosening bowel to relieve constipation, moisturize parasite killing,

[clinical name] has Fructus Cannabis core, stir-baked FRUCTUS CANNABIS core.

Folium ailanthi:

[return through] lung meridian

[chemical composition of Chinese materia medica]: leaf is containing globulariacitrin (rutin), afzelin (afzelin), quercitrin (quercitrin), Isoquercitrin (isoquercitrin), nimbecetin (kaempferol), bark element (quercetin) and aminoacid (amino acid).

[effect]: heat clearing and damp drying; Parasite killing

[textual criticism]: come from Compendium of Material Medica section and belong to classification: Simarubaceae

[curing mainly]: damp and hot dysentery; Have loose bowels; Dysentery; Eczema; Skin ulcer scabies; Furuncle and phyma.

Rhizoma et radix veratri (Radix Rhizoma Veratri):

[effect] vomiting wind-phlegm by emesis, heat-clearing and toxic substances removing, parasite killing.

[curing mainly] is controlled middle wind-phlegm and is gushed, the insane disease of acute infantile convulsion, jaundice, and chronic malaria, lets out dysentery, headache, sore throat, breath, scabies, malignant boil.In addition, grind into powder with this product and exosmose, have delousing effect.Eliminate the phlegm, emetic, parasite killing.Stop up for middle wind-phlegm, epilepsy, malaria, fracture; Scabies is controlled in external, fly eradication maggot.

[nature and flavor] toil, cold, poisonous.

1. " herbal classic ": " acrid in the mouth, cold.”

2. " not Lu ": " bitter, be slightly cold, poisonous "

[return through] " Bencao Jingshu ": " lunar, Foot yangming Channel of starting with." " book on Chinese herbal medicine is new again " " enter Liver Channel.”

Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian.Function cures mainly: eliminating turbid pathogen with aromatics, and appetizing preventing or arresting vomiting, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, and heat-damp in summer asthenia is not uncomfortable in chestly relaxed, and cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache." kind reason Central Region turbid damp sputum, is fast stomach of being amusing, vibrates clear positive quality goods for Herba Pogostemonis, delicate fragrance tepor." not Lu " controls the swollen person of edema due to wind pathogen poison, and dispel turbid damp, self energy clear the course also.1. the effect of antifungic action 2. anti-leptospira effect 3. antivirus action 4. pairs of digestive system.

Radix Raphani:

Radix Raphani has another name called Radix Raphani, sieve clothes.

[nature and flavor] Xin Gan is cool;

[return through ]enter lung, stomach warp;

[function cures mainly] removing food stagnancy is stagnant, heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, removing toxic substances.Control food stagnation distension, phlegmatic cough aphonia, spit blood, epistaxis, quenches one's thirst, dysentery, migraine and general headache.

1. " not Lu ": " main sharp the five internal organs, beneficial rational diet gas." 2. Tang Materia Medica: " loose clothes and big gun boil to be taken, the large therapeutic method to keep the adverse QI flowing downwards, and rapid digestion of food, removes accumulation of phlegm in the hypochondrium; Raw juice of smashing takes, and master quenches one's thirst."

3. the Meng numerous: " bad odor in the five internal organs, except the five internal organs apoplexy, is practiced in very sharp joint."

4. " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " ordinary person surfeits, and rawly chews just disappearing of pharynx, and also main lung is coughed haematemesis."

5. " feeding habits book on Chinese herbal medicine ": " sector-style gas, uncharm steam." " flower: improving eyesight."

6. " Japan hanako materia medica ": " energy stopping coughing and removing phlegm; Control consumptive lung disease to spit blood; Warming middle-JIAO, tonifying for the deficiency, control the thin cough of labor, and Carnis caprae seu ovis, Carassius auratus cooks it."

7. " daily book on Chinese herbal medicine ": " the chest stuffiness relieving diaphragm, sharp defecation.Prepared food it, reduce phlegm rapid digestion of food; Life eats it, and quench the thirst alleviating distention in middle-JIAO."

8. Wang Ying " food book on Chinese herbal medicine ": " clothes are smash in life, control fasting dysentery."

9. " book on Chinese herbal medicine can be compiled ": " kill fishy smell, control bean curd and amass."

10. " detailed outline ": " main acid regurgitation, eliminate indigestion is stagnant, alcoholic intoxication, and dissipating blood stasis blood, very imitates.End clothes control five types of stranguria; Ball clothes control nebulousurine; Decoct soup foot bath gas; Drink juice controls the inferior dysentery and aphonia, and sootiness is for extremely; Raw smash be coated with beat flutter, burn."

(11) " book on Chinese herbal medicine is looked for the truth ": " separate Radix Aconiti Lateralis Preparata poison."

(12) " occupy diet spectrum with breath ": " control cough with aphonia, all diseases of throat; Separate carbon monoxide poisoning, Fructus Solani melongenae poison.Ripe person's therapeutic method to keep the adverse QI flowing downwards and in, spleen reinforcing fortune food, born fluid, imperial wind and cold, foul leukorrhea, damp fetal cultivation blood."

Fructus Amomi:

[nature and flavor] are warm in nature, acrid in the mouth,

During [function] circulation of qi promoting is adjusted, stomach function regulating, is amusing, and be applicable to breast gastral cavity painful abdominal mass vexed, abdominal distention is eaten less, and the stomachache caused due to Deficiency and coldness of spleen and stomach is had loose bowels.

Rhizoma Scopoliae Japonicae:

[meridian distribution of property and flavor] is warm in nature, taste fiber crops: have severe toxicity.Enter the heart, liver, lung meridian.

[function cures mainly] controls eating accumulation, dysphagia and regurgitation.

1. supplement to the Herbal: " QI invigorating is made light of one's life by commiting suicide, hard muscles and bones."

2. " Kangxu's investigate things of a little free time volume ": " property warms up, strengthening the spleen stomach, and be easy to digestion, do not tell well person, polyphagia is useful."

3. " property of medicine is examined ": " heat clearing away pathogenic wind expelling."

4. " detailed outline is picked up any lost article from the road ": " tonneau large intestine, disappear dyspepsia, controls dysphagia and regurgitation."

Herba Moghaniae fruticulosa:

[nature and flavor] micro-hardship is sweet, cool.Return through lung; Spleen channel

[function cures mainly] brings down a fever dehumidifying, and disappear infantile malnutrition, cough-relieving.Control hyperpyrexia, flu, rheumatic arthritis, dysmenorrhea, infantile malnutrition, diarrhoea, dyspepsia.

Herba Piperris Tonkinensis:

[meridian distribution of property and flavor] is pungent, temperature.

[function cures mainly] expelling wind and cold, eliminating stasis to stop pain.For flu, bones and muscles pain due to rheumatism, treating swelling and pain by traumatic injury, dysmenorrhea, amenorrhea, cold syndrome of the stomach pain; Poisonous snake, centipete bite are controlled in external.

Radix Schisandrae Bicoloris:

Nature and flavor: bitter; Puckery; Warm in nature

Gui Jing: liver; Stomach warp

Function cures mainly: dredge the meridian passage; Spleen benefiting and stimulating the appetite.Main impairment caused by overstrain takes off power; Extremity are tingle; Breast is vexed; Indigestion and loss of appetite.

Rhizoma Alpiniae Officinarum:

[meridian distribution of property and flavor] is pungent, heat.Return spleen, stomach warp.

[function cures mainly] warming stomach for dispelling cold, help digestion pain relieving.For coldness and pain in the epigastrium, gastrofrigid vomiting, belch acid regurgitation.

The Radix Aucklandiae:

[nature and flavor] are warm in nature, acrid in the mouth, hardship,

[function] promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach, is applicable to the intestines and stomach stagnation of QI, and chest and abdomen swelling and pain and the stagnant caused abdominal and hypochondriac pain of liver and gall damp-heat and vomiting, have loose bowels, dysentery, pain in the abdomen is strict heavy, colic of cold type etc.

Flos Ginseng:

[nature and flavor]: bitterness Hui Tian, have the pungent sweet taste of Radix Ginseng.

[function]: supplement vitality of human body, regain one's strength, strengthens body immunity.

Herba Portulacae:

[meridian distribution of property and flavor] acid, cold; Return liver, large intestine channel.

[function cures mainly] is applicable to dysentery (defecate half-dried half rare), heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.Modern times are used for the treatment of enteritis, acute arthritis, cystitis, urethritis, anusitis, bleeding hemorrhoids etc. mostly.Collective Notes to the Canon of Materia medica " Bencao Tujing " is come from textual criticism: Herba Portulacae, has another name called five elements' grass, blue or green with its leaf, obstructs red, brightly yellowish, and root is white, and son is also black.Cure mainly: pyretic toxicity dysentery; Pyretic stranguria; Urine retention; Leucorrhea with red and white discharge; Metrorrhagia; Hemorrhoidal bleeding; Skin infection carbuncle furuncle; Erysipelas; Scrofula; Exudative dermatitis; Bald in vain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": QI invigorating, clearing away summer-heat heat, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, intestine moistening, removing food stagnancy is stagnant, parasite killing, treats skin ulcer congestion and swelling pain.

The Radix Linderae:

[nature and flavor] acrid in the mouth, warm in nature. enter spleen, lung, kidney, urinary bladder channel.

[function cures mainly] is pleasant, dissipating depression of QI, cold expelling, pain relieving. cure mainly: QI rising in reverse order chest and abdomen swelling and pain, dyspepsia do not disappear, food, colic of cold type, beriberi, frequent micturition are told in regurgitation.

detailed description of the invention:

Embodiment 1, formula:

Fructus Aurantii 5g, Caulis Akebiae 5g, Fructus Chebulae 5g, Semen Persicae 5g, Flos Sophorae 5g, Fructus Cannabis 1g, Folium ailanthi 1g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1g, Herba Pogostemonis 1g, Radix Raphani 1g, Fructus Amomi 0.1g, Rhizoma Scopoliae Japonicae 0.1g, Herba Moghaniae fruticulosa 0.1g, Herba Piperris Tonkinensis 0.1g, Radix Schisandrae Bicoloris 0.1g, Rhizoma Alpiniae Officinarum 1g, Radix Aucklandiae 1g, Flos Ginseng 1g, Herba Portulacae 1g, Radix Linderae 1g;

Preparation method:

By formula proportion, above-mentioned Chinese medicine ovendry power is broken into 300-400 object fine powder and uses ultrasound wave homogenize 10-30 minute at 0-10 DEG C of temperature, incapsulate after mix homogeneously and get product;

Instructions of taking: half an hour ante cibum takes with warm water, every day three times, each serving with 15g, warm water delivery service one month is a course for the treatment of, and 2-3 courses for the treatment of cure.To avoid cold and uncooked food the thing of pungent stimulation.

Embodiment 2, formula:

Fructus Aurantii 6g, Caulis Akebiae 6g, Fructus Chebulae 6g, Semen Persicae 6g, Flos Sophorae 6g, Fructus Cannabis 2g, Folium ailanthi 2g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2g, Herba Pogostemonis 2g, Radix Raphani 2g, Fructus Amomi 0.2g, Rhizoma Scopoliae Japonicae 0.2g, Herba Moghaniae fruticulosa 0.2g, Herba Piperris Tonkinensis 0.2g, Radix Schisandrae Bicoloris 0.2g, Rhizoma Alpiniae Officinarum 2g, Radix Aucklandiae 2g, Flos Ginseng 2g, Herba Portulacae 2g, Radix Linderae 2g.

Preparation method is identical with embodiment 1.

Embodiment 3, formula:

Fructus Aurantii 8g, Caulis Akebiae 8g, Fructus Chebulae 8g, Semen Persicae 8g, Flos Sophorae 8g, Fructus Cannabis 4g, Folium ailanthi 4g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 4g, Herba Pogostemonis 4g, Radix Raphani 4g, Fructus Amomi 0.5g, Rhizoma Scopoliae Japonicae 0.5g, Herba Moghaniae fruticulosa 0.5g, Herba Piperris Tonkinensis 0.5g, Radix Schisandrae Bicoloris 0.5g, Rhizoma Alpiniae Officinarum 4g, Radix Aucklandiae 4g, Flos Ginseng 4g, Herba Portulacae 4g, Radix Linderae 4g.

Preparation method is identical with embodiment 1.

Embodiment 4, formula:

Fructus Aurantii 9g, Caulis Akebiae 9g, Fructus Chebulae 9g, Semen Persicae 9g, Flos Sophorae 9g, Fructus Cannabis 5g, Folium ailanthi 5g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 5g, Herba Pogostemonis 5g, Radix Raphani 5g, Fructus Amomi 0.8g, Rhizoma Scopoliae Japonicae 0.8g, Herba Moghaniae fruticulosa 0.8g, Herba Piperris Tonkinensis 0.8g, Radix Schisandrae Bicoloris 0.8g, Rhizoma Alpiniae Officinarum 5g, Radix Aucklandiae 5g, Flos Ginseng 5g, Herba Portulacae 5g, Radix Linderae 5g.

Preparation method is identical with embodiment 1.

Embodiment 5, formula:

Fructus Aurantii 10g, Caulis Akebiae 10g, Fructus Chebulae 10g, Semen Persicae 10g, Flos Sophorae 10g, Fructus Cannabis 6g, Folium ailanthi 6g, Rhizoma et radix veratri (Radix Rhizoma Veratri) 6g, Herba Pogostemonis 6g, Radix Raphani 6g, Fructus Amomi 0.9g, Rhizoma Scopoliae Japonicae 0.9g, Herba Moghaniae fruticulosa 0.9g, Herba Piperris Tonkinensis 0.9g, Radix Schisandrae Bicoloris 0.9g, Rhizoma Alpiniae Officinarum 6g, Radix Aucklandiae 6g, Flos Ginseng 6g, Herba Portulacae 6g, Radix Linderae 6g;

Preparation method:

By formula proportion, above-mentioned Chinese medicine ovendry power is broken into 300-400 object fine powder and uses ultrasound wave homogenize 10-30 minute at 0-10 DEG C of temperature, incapsulate after mix homogeneously and get product;

Instructions of taking: half an hour ante cibum takes with warm water, every day three times, each serving with 15g, warm water delivery service one month is a course for the treatment of, and 2-3 courses for the treatment of cure.To avoid cold and uncooked food the thing of pungent stimulation.

diagnostic point:

The Nausea and vomiting that gastroenteritis causes is fallen ill comparatively anxious usually, does not slowly feel any better, starts many abdominal discomforts, then Nausea and vomiting.Abdominal part paroxysmal colic also has diarrhoea, and every number of days is to tens of watery stools, and yellow or yellow green, containing a small amount of mucus.With heating in various degree, aversion to cold, headache etc.Minority case because of frequent vomiting and diarrhoea, can cause dehydration and electrolyte disturbance, acidosis.

Pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of invention formulation and Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

Pharmacological experiment

1, experiment material

Purchased from Shandong Experimental Animal Center, cleaning grade.

1.2 medicines and reagent: capsule of the present invention; Ranitidine Capsules (Yan'an, Shanghai everything Pharmaceutical joint stock company limited, lot number: 040301); Glacial acetic acid (AR, Shantou City's brilliance laboratory); Dehydrated alcohol (AR, Yang Yuan chemical plant, Changshu, Jiangsu Province city).

1.3 statistical procedures Excel l softwares carry out date processing,

1.1 animal SD rats, male and female dual-purpose, each group all carries out t inspection with matched group.

2 methods and result

The gastrointestinal inflammatory effect of 2.1 pairs of rat water logging irritability.

Get healthy rat 50, body weight 180 ± 20g, male and female half and half, the basic, normal, high dosage group of capsule of the present invention (dosage is respectively: 2.75g/kg, 5.5g/kg and 1 lg/kg) is divided at random: ranitidine group (dosage is 200mg/kg) and distilled water matched group by sex, body weight.10/group, all by 1.5ml/l00mg, every day gastric infusion 1 time, continuous 5d.After 3d gavage, water 48h is can't help in fasting, and after last administration, rat is bound by plate by 1h, immerses in 23 ± 0.5 DEG C of thermostatic water tanks, sacrificed by decapitation after 18h, cut open the belly ligation pylorus and cardia.Get stomach and to gastric injecting normal saline 10ml.Be placed in after 10% formalin fixes 10min, cut along greater gastric curvature, wash away gastric residue with normal saline, observe and evaluate gastrointestinal inflammation index.Assessment method: gland area occurs that the length of streak damage is greater than lmm person, measures its length, and every mm counts 1 point, its width is greater than lmm person's score to be doubled, and length and width are all less than lmm, count 0.5 point, score are added the inflammation index being this Mus.Result shows, capsule of the present invention three dosage groups all have obvious inhibitory action to stress in rats gastrointestinal inflammation, compare P<0.01 or 0.05 with matched group.Refer to table 1.

Table 1 capsule of the present invention is to the effect (-x ± S) of rat water logging irritability gastroenteritis

2.2 pairs of rats acetic acids burn the effect healthy rat 40 of type gastroenteritis, body weight 200 ± 20g, male and female half and half, fasting 24h, freely drink water, ether light anaesthesia, abdominal cavity is opened under aseptic technique, stomach is pulled out gently, an osculum is cut at coat of the stomach, by internal diameter 5mm, the little glass-tube of long 3cm inserts gastric by otch, middle finger directes reach the glandular stomach portion above offside pylorus, the little glass-tube of fastening, in pipe, glacial acetic acid 0.1ml is injected with syringe, make to contact lmin with gastric mucosa, then with glacial acetic acid in disinfecting cotton swab exhaustion pipe, remove glass-tube, sew up the incision, omentum majus covers hinders face, send stomach back to abdominal cavity, sew up, sterilization.Within postoperative 2nd day, rat is divided into 5 groups at random by sex, body weight, grouping and medication before, every day gavage 1 time, successive administration 11d.Fasting 24h after last administration, sacrificed by decapitation, cut open the belly ligation pylorus and cardia.Get stomach and to gastric injecting normal saline 10ml, be placed in after 10% formalin fixes l0min, cut along greater gastric curvature, wash away gastric residue with normal saline, measure inflammation area.As a result, capsule of the present invention three dosage groups burn type gastrointestinal inflammation to rats acetic acid all obvious inhibitory action, compares P<0.0l with matched group.Refer to table 2.

Table 2 capsule of the present invention is to the gastrointestinal inflammatory effect of rat water logging irritability (-x ± S)

2.3 gastric analysis healthy rats 40, body weight 190 ± 20g, male and female half and half.Divide 5 groups at random by body weight, sex, grouping and medication ditto, continuous use 5 days.Pre-operative anxiety can't help water 48h, after last administration 2h, and surgical ligation pylorus, sacrificed by decapitation after fasting taboo water 5h, ligation cardia of cutting open the belly.Get stomach, collect gastric juice, centrifugal 10min (3000r/min), measure free acid, total acid, pepsin activity.Gastric acidity determination adopts acid base neutralization titration method, and determination of peptic activity adopts capillary glass-tube method (Mett method).Result shows, capsule high dose group of the present invention has obvious inhibitory action to rat stomach proteinase activity, compares P<0.05 with matched group.Also impact is had on gastric acid secretion.In table 3.

Table 3 capsule of the present invention is to the effect of rat gastric secretion

Note: compare with matched group: * P<0.05.

1 clinical data

1 clinical data

1.1 physical data are diagnosed as gastrointestinal inflammatory patient 100 example under choosing gastroscope altogether, adopt random digits table to be divided into treatment group and matched group at random, two groups of each 50 examples, wherein treatment group man 30 example, female 20 example; 22-58 years old ages; Matched group man 33 example, female 17 example, 21-59 years old ages, two groups of ages, sex through statistical procedures, no significant difference (P>0.05).

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard is with reference to " internal medicine " " and " new Chinese medicine guideline of clinical investigations " draft.(1) symptom and sign: the chronic epigastrium pain of the periodicity of prolonged and repeated generation, rhythmicity, using basic medicine can be alleviated; Epigastrium has limitation deeply in tenderness; (2) auxiliary examination: see active stage inflammation under gastroscope, pathologic finding has no malignant cell.

1.2.2 traditional Chinese medical science stagnation of liver-QI spleen feebleness diagnosis standard is with reference to " guideline of clinical investigations of new Chinese medicine treatment syndrome of stagnation of liver qi and spleen deficiency ".Primary symptom: gastric abscess or side of body costalgia, abdominal distention, lack of appetite is indigestion and loss of appetite, and loose stool is not well.Secondary disease: be in a very depressed state or being irritable and getting angry easily, sighing frequently, intestinal toot arrow gas, namely stomachache rush down, and rush down rear alleviation of pain, tongue fur is white or greasy, stringy pulse or thin.Primary symptom 3 (gastral cavilty or the side of body costalgia) is indispensable, or primary symptom 2 gastral cavilties or side of body costalgia indispensable), secondary disease 2, namely diagnosable.

1.3 case inclusive criterias are all meets two doctor's Disease Diagnosis Standards and TCM Syndrome Type diagnostic criteria and outside exclusion standard, and age person between 20-60 years old all can be used as and includes case in.Participate in experimenter and all sign Informed Consent Form.

There is complication in 30 d before the test and carry out operator in 1.4 case exclusion standards (1).(2) gastric ulcer of cause specific is had, as gastrinoma etc.(3) anemia of pregnant woman, women breast-feeding their children or may conceived person at period in a medicine.(4) there are other complication to affect the treatment and observe or have the disease of taboo to observing medicine.(5) indulge in excessive drinking, smoke the person that maybe can not coordinate with dietetic regulation.(6) other organ serious diseases person that needs medication treatment is had.(7) not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.

2 Therapeutic Method

2.1 instructions of taking: half an hour ante cibum takes with warm water, every day three times, each serving with 15g, warm water delivery service one month is a course for the treatment of, and 2-3 courses for the treatment of cure.To avoid cold and uncooked food the thing of pungent stimulation.

3 observation of curative effect

3.I observation item (1) tcm syndrome (primary symptom, secondary disease) observes weekly its change.(2) costalgia, the time of abdominal distention outbreak, number of times, degree, persistent period, induced factor is coerced.(3) relevant sign: blood pressure, pulse, body temperature, breathing, tongue, arteries and veins.(4) relevant physico-chemical examination: gastroscope, blood routine examination, each inspection 1 time before and after treatment.Within 1 year, check 1 time afterwards.

The general health check-up project of 3.2 security inspections (1).(2) blood, urine, stool routine examination.(3) electrocardiogram, hepatic and renal function.

3.3 criterion of therapeutical effect

3.3.I gastroscopy effect criterion (I) clinical recovery: inflammation disappears completely, local mild hyperaemia, without obvious edema.(2) effective: inflammation disappears substantially, still have obvious inflammation.(3) effective: inflammation area reduces more than 50%.(4) invalid: inflammation area reduces not as good as 50%.

3.3.2 therapeutic effect of syndrome criterion is formulated with reference to " new Chinese medicine guideline of clinical investigations " l.Statistics symptom improve integration (primary symptom is divided gently, in, heavily respectively meter 3 points, 5 points, 7 points, secondary disease counts 1 point, 2 points, 3 points respectively, asymptomatic meter zero), namely gastroscope is checked after 1 course for the treatment of terminated, the recent healing rate of statistics inflammation (recovery from illness and effective person are considered as healing, are designated as healing rate), total effective rate; Cure and follow up a case by regular visits to for latter 1 year, check gastroscope statistics inflammation relapse rate.

3.4 statistical procedures all data acquisition SPSS12.0 statistical software adds up, and before and after treatment, data compare employing x inspection and t inspection, and group is asked to compare and analyzed with Ridit.

3.5 therapeutic outcomes are in table 1-3.

Under table 1 liang organizes total effective rate and gastroscope, healing rate compares (example)

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)	Healing rate (%)
								Treatment group	50	34	11	2	3	94	88
Matched group	50	26	12	5	7	86	86

Table 1 statistical analysis is pointed out: under treatment group and the gastrointestinal inflammatory total effective rate for the treatment of of control group and mirror, healing rate compares, the equal not statistically significant of difference (P>0.05).

A table 2 liang group Chinese medicine syndrome integral compares (x ± s, point)

Group	n	Before treatment	After treatment
				Treatment group	50	25．21±2．5	11．81±2．42
Matched group	50	24．41±1．34	12．51±2．54

Table 2 statistical analysis is pointed out: treat front two groups of integration no significant difference, after treatment, two groups of integrations are compared with before treatment, difference all has statistical significance (P<0.01), two groups of integral contrasts after treatment, difference has statistical significance (P<0.05).

After table 3 liang organizes 1 year, inflammation relapse rate compares (example)

Group	n	Recurrence	Recovery from illness	Relapse rate (%)
					Treatment group	50	5	45	10
Matched group	50	9	41	18

Table 3 statistical analysis is pointed out: treatment group relapse rate compares with matched group, and difference has statistical significance (P<0.05).

Model case:

Case 1 :

Certain patient, suffers from the long-term gastritis of bile reflux repeatedly, on an empty stomach with regard to acid regurgitation, eaten thing and just told in the morning, and Western medicine is eaten a lot, is all work as fashion, later again dying.Take time Chinese medicine preparation of the present invention has the 3rd day and reacted some act of violence, very uncomfortable in morning stomach, think it may is degree of depth treatment, adhere to again having taken a course for the treatment of, when eating second course for the treatment of, to feel in stomach not so acid regurgitation, and ate thing and to think in stomach that also very easily, sleep is also felt better.I has bought again a course for the treatment of and has consolidated.Drug withdrawal one day after than one day easily.Real feels that healthy beyond all else is important.

Case 2:

Open x, man, 45 years old.Clinical manifestation, stomach rises, inappetence, feels sick, what is eaten what is vomitted, be diagnosed as chronic gastrointestinal inflammation, take a course for the treatment of, stomachache, and stomach rises disappearances, and vomiting, grade of feeling sick transference cure, the state of an illness heals entirely.

Case 3:

In xx, man, 22 years old.Suffer from chronic gastroenteritis.Clinical manifestation is stomachache, inappetence.After taking a course for the treatment of of this medicine, stomachache disappears, and appetite is recovered.

Case 4:

Lu xx, man, 35 years old.Suffer from chronic gastritis.Clinical manifestation is had a stomachache for a long time, and stomach rises, and appetite is depressed for a long time, and after taking a course for the treatment of, stomachache, stomach rises disappearance, and the state of an illness heals entirely.

Case 5:

Strange x, man, 42 years old.Frequent diarrhoea.Be diagnosed as chronic gastrointestinal inflammation, clinical manifestation be mucus pus and blood shape just, stomachache.Take a course for the treatment of of this preparation, stool chemical examination is normal.

Case 6:

Hao xx, man, 20 years old.Suffer from chronic gastritis.Clinical manifestation is had a stomachache for a long time, and stomach rises, and appetite is depressed for a long time, takes a course for the treatment of, stomachache, and stomach rises disappearance, and the state of an illness heals entirely.

Case 7:

In certain, man, 46 years old, more than 10 years of Stomach in Patients gastralgia. increase the weight of two weeks.Patient is because feelings will is not smooth before two weeks, and gastric abscess shows effect, gastral cavilty distension pain, and two side of body distending pains, belch is done frequently.Diet is depressed, light red tongue. white and thin fur, stringy pulse.Barium meal examination. prompting: gastroenteritis.Chinese medical discrimination. belong to hepatic qi attacking stomach type.Give liver-smoothing, qi-regulating, and stomach and alleviating pain Chinese medicine preparation of the present invention, patient takes after 5 doses, and pain subtracts greatly, and all diseases all alleviate. patient takes 30 doses altogether, through x line Barium meal examination. prompting: stomach bull film is smooth.Patient fully recovers. and follow up a case by regular visits to and do not recur for 1 year.

Claims (3)

1. treat a Chinese medicine composition for chronic gastrointestinal inflammation, it is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 5-10 part, Caulis Akebiae 5-10 part, Fructus Chebulae 5-10 part, Semen Persicae 5-10 part, Flos Sophorae 5-10 part, Fructus Cannabis 1-6 part, Folium ailanthi 1-6 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 1-6 part, Herba Pogostemonis 1-6 part, Radix Raphani 1-6 part, Fructus Amomi 0.1-0.9 part, Rhizoma Scopoliae Japonicae 0.1-0.9 part, Herba Moghaniae fruticulosa 0.1-0.9 part, Herba Piperris Tonkinensis 0.1-0.9 part, Radix Schisandrae Bicoloris 0.1-0.9 part, Rhizoma Alpiniae Officinarum 1-6 part, Radix Aucklandiae 1-6 part, Flos Ginseng 1-6 part, Herba Portulacae 1-6 part, Radix Linderae 1-6 part;

Preparation method:

By formula proportion, above-mentioned Chinese medicine ovendry power is broken into 300-400 object fine powder and uses ultrasound wave homogenize 10-30 minute at 0-10 DEG C of temperature, incapsulate after mix homogeneously and get product.

2. a kind of Chinese medicine composition for the treatment of chronic gastrointestinal inflammation according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 6-9 part, Caulis Akebiae 6-9 part, Fructus Chebulae 6-9 part, Semen Persicae 6-9 part, Flos Sophorae 6-9 part, Fructus Cannabis 2-5 part, Folium ailanthi 2-5 part, Rhizoma et radix veratri (Radix Rhizoma Veratri) 2-5 part, Herba Pogostemonis 2-5 part, Radix Raphani 2-5 part, Fructus Amomi 0.2-0.8 part, Rhizoma Scopoliae Japonicae 0.2-0.8 part, Herba Moghaniae fruticulosa 0.2-0.8 part, Herba Piperris Tonkinensis 0.2-0.8 part, Radix Schisandrae Bicoloris 0.2-0.8 part, Rhizoma Alpiniae Officinarum 2-5 part, Radix Aucklandiae 2-5 part, Flos Ginseng 2-5 part, Herba Portulacae 2-5 part, Radix Linderae 2-5 part.

3. a kind of Chinese medicine composition for the treatment of chronic gastrointestinal inflammation according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Fructus Aurantii 8 parts, Caulis Akebiae 8 parts, Fructus Chebulae 8 parts, 8 parts, Semen Persicae, 8 parts, Flos Sophorae, Fructus Cannabis 4 parts, Folium ailanthi 4 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 4 parts, Herba Pogostemonis 4 parts, Radix Raphani 4 parts, Fructus Amomi 0.5 part, Rhizoma Scopoliae Japonicae 0.5 part, Herba Moghaniae fruticulosa 0.5 part, Herba Piperris Tonkinensis 0.5 part, Radix Schisandrae Bicoloris 0.5 part, Rhizoma Alpiniae Officinarum 4 parts, the Radix Aucklandiae 4 parts, Flos Ginseng 4 parts, Herba Portulacae 4 parts, the Radix Linderae 4 parts.