CN104873781A - Traditional Chinese medicine for treating phlegm and heat-accumulated lung type chronic bronchitis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating phlegm and heat-accumulated lung type chronic bronchitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating phlegm and heat-accumulated lung type chronic bronchitis and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials of calamint, lemonfragrant ostericum root, honewort, sage, serissa serissoide, Spanish moss, leontopodium longifolium ling, common saurauia root, rupestrine dragonhead herb, capitatestigma willowweed herb, Potentilla kleiniana, pilose gerbera herb and smallflower epipactis root. The traditional Chinese medicine has the advantages that the effect of treating the phlegm and heat-accumulated lung type chronic bronchitis is obvious, and the toxic and side effect is little.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of phlegm-heat accumulated in the lung type chronic bronchitis.
Background technology
Chronic bronchitis is the chronic nonspecific inflammatory diseases betiding trachea-bronchial epithelial cell mucosa and surrounding tissue caused by various infection or non-infective agent.Be a kind of commonly encountered diseases, frequently-occurring disease, in mid-aged population, sickness rate is 15-20%, and main clinical characteristics is cough, the expectoration of recurrent exerbation or accompanies wheezing symptoms, and the symptom annual persistent period is much in 3 months, continuous more than 2 years.State of an illness lasting for years person Chang Bingfa has a strong impact on healthy emphysema and chronic pulmonary heart disease.
Chronic bronchitis belongs to the category such as " cough ", " phlegm syndrome ", " the syndrome of dyspnea " in Chinese medicine more.The generation of phlegm retention is except being invaded by exogenous pathogen is common inducement, and the intrinsic factor of patient are particularly important, and mainly because qiactivity of triple energizer loses a surname, yang deficiency water liquid is not transported and caused.The etiology and pathogenesis of chronic bronchitis is: endlessly, recurrent exerbation causes insufficiency of lung-QI to chronic cough, and mistake department falls in a surname, the cough with asthma abundant expectoration of phlegm retention volt lung, transporting and transforming function of the spleen and stomach mistake department, contains criminals lung in phlegm-damp thus cough, expectoration in a large number, prolonged illness is involved in kidney, deficiency of kidney-QI, takes the photograph to receive and haves no right, then pant very brief.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of phlegm-heat accumulated in the lung type chronic bronchitis, Chinese medicine of the present invention has definite curative effect to phlegm-heat accumulated in the lung type chronic bronchitis, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of phlegm-heat accumulated in the lung type chronic bronchitis, its raw medicinal material comprises: Herba Clinopodii Polycephali, Radix osterici citriodori (Radix Angelicae Citriodorae), Herba abutili indici, Arisaema balansae Engl. grass, Serissa foetida, Ramulus et folium henslowiae frutescentis, rabbit ear grass, Radix Saurauiae Tristylae, Herba Dracocephali Rupestris, Herba Epilobii, Herba potentillae kleinianae, Herba Gerberae Piloselloidis and Radix epipactinis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Clinopodii Polycephali 5 ~ 15 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 15 parts, Herba abutili indici 10 ~ 20 parts, Arisaema balansae Engl. grass 15 ~ 25 parts, Serissa foetida 5 ~ 15 parts, Ramulus et folium henslowiae frutescentis 5 ~ 15 parts, rabbit ear grass 15 ~ 25 parts, Radix Saurauiae Tristylae 10 ~ 20 parts, Herba Dracocephali Rupestris 10 ~ 20 parts, Herba Epilobii 15 ~ 25 parts, Herba potentillae kleinianae 25 ~ 35 parts, Herba Gerberae Piloselloidis 45 ~ 55 parts and Radix epipactinis 25 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Clinopodii Polycephali 5 ~ 10 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 10 parts, Herba abutili indici 10 ~ 15 parts, Arisaema balansae Engl. grass 15 ~ 20 parts, Serissa foetida 5 ~ 10 parts, Ramulus et folium henslowiae frutescentis 5 ~ 10 parts, rabbit ear grass 15 ~ 20 parts, Radix Saurauiae Tristylae 10 ~ 15 parts, Herba Dracocephali Rupestris 10 ~ 15 parts, Herba Epilobii 15 ~ 20 parts, Herba potentillae kleinianae 25 ~ 30 parts, Herba Gerberae Piloselloidis 45 ~ 50 parts and Radix epipactinis 25 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Clinopodii Polycephali 6 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 7 parts, Herba abutili indici 12 parts, Arisaema balansae Engl. grass 16 parts, Serissa foetida 8 parts, Ramulus et folium henslowiae frutescentis 7 parts, rabbit ear grass 18 parts, Radix Saurauiae Tristylae 14 parts, Herba Dracocephali Rupestris 11 parts, Herba Epilobii 17 parts, Herba potentillae kleinianae 28 parts, Herba Gerberae Piloselloidis 47 parts and Radix epipactinis 26 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the starch of 0.3 ~ 0.5 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 2 ~ 5cm, soak 3 ~ 6 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 30 ~ 60 minutes dosage to medicinal liquid be slowly 200 ~ 400ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 2 ~ 3cm, soaks 3 ~ 6 hours; 20 ~ 30 minutes dosage to medicinal liquid is 100 ~ 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to phlegm-heat accumulated in the lung type chronic bronchitis, and toxic and side effects is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of phlegm-heat accumulated in the lung type chronic bronchitis, its raw medicinal material comprises: Herba Clinopodii Polycephali, Radix osterici citriodori (Radix Angelicae Citriodorae), Herba abutili indici, Arisaema balansae Engl. grass, Serissa foetida, Ramulus et folium henslowiae frutescentis, rabbit ear grass, Radix Saurauiae Tristylae, Herba Dracocephali Rupestris, Herba Epilobii, Herba potentillae kleinianae, Herba Gerberae Piloselloidis and Radix epipactinis.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Herba Clinopodii Polycephali: [source] is the herb of labiate Herba Clinopodii Polycephali.[nature and flavor] are bitter, pungent, cool.[function cures mainly] wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Cure cold, heatstroke, acute cholecystitis, hepatitis, enteritis, dysentery, parotitis, mastitis, furuncle swelling toxin, allergic dermatitis, acute conjunctivitis.
Radix osterici citriodori (Radix Angelicae Citriodorae): the root that [source] is samphire Radix osterici citriodori (Radix Angelicae Citriodorae) or herb.[nature and flavor] acrid in the mouth, micro-hardship, property is put down.[function cures mainly] wind and heat dispersing, expelling phlegm for arresting cough, reducing swelling and alleviating pain.Main flu, cough, headache, stomachache, dysentery, hepatitis, rheumatic arthralgia, hernia, menoxenia, traumatic injury wound is swollen, carbuncle sore, venom.
Herba abutili indici: [source] is the herb of Malvaceae plant Herba abutili indici.[nature and flavor] are sweet, light, cool in nature.[return through] returns lung, kidney channel.[function cures mainly] wind and heat dispersing, preventing phlegm from forming and stopping coughing, subduing swelling and detoxicating.Main flu, heating, cough, has loose bowels, otitis media, deaf, pharyngitis, parotitis, urinary tract infection, sore and toxic, traumatic injury.
Arisaema balansae Engl. grass: [source] is labiate Huangpu rattail root herb.[nature and flavor] micro-hardship, cool in nature.[function cures mainly] wind and heat dispersing, dampness removing, arresting bleeding and miscarriage prevention.Main cold, fever, pneumonia cough with asthma, laryngopharynx swelling and pain, hepatitis hypochondriac pain, diarrhoea, dysentery, nephritis, spits blood, vaginal bleeding during pregnancy.
Serissa foetida: [source] is the herb of Maguireothamnus speciosus Serissa foetida.[nature and flavor] are light, micro-pungent, cool.[function cures mainly] dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.For flu, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea.
Ramulus et folium henslowiae frutescentis: [source] is the Herb of Santalaceae phytotrophy rattan.[nature and flavor] are micro-sweet, bitter, puckery, and property is put down.[return through] returns lung, Liver Channel.[function cures mainly] wind and heat dispersing, promoting blood circulation and stopping pain.Main influenza, traumatic injury.
Rabbit ear grass: [source] is the herb of feverfew Herba Leontopodii longifolii.[nature and flavor] acrid in the mouth, cool in nature.[function cures mainly] wind and heat dispersing, relieving cough and resolving phlegm.Main fever caused by exogenous pathogens, cough due to lung-heat, bronchitis.
Radix Saurauiae Tristylae: the root that [source] is Actinidiaceae vegetation water Folium Eriobotryae or leaf.[nature and flavor] micro-hardship, cool.[return through] returns lung meridian.[function cures mainly] wind and heat dispersing, cough-relieving, pain relieving.Main air cough caused by pathogenic damp is coughed, acute toothache, and measles is generated heat, urinary tract infection, nebulousurine, leucorrhea, furuncle carbuncle, osteomyelitis, scalds.
Herba Dracocephali Rupestris: [source] is the herb of labiate Mao Jiancao.[nature and flavor] acrid in the mouth is bitter, cool in nature.[function cures mainly] wind and heat dispersing, cool liver hemostasis.Main anemopyretic cold, headache, laryngopharynx swelling and pain, cough, jaundice, dysentery, spits blood, epistaxis.
Herba Epilobii: [source] is the herb of onagraceae plant Piper pulicatulum C. D C. LIUYECAI.[nature and flavor] bitter in the mouth, pungent, property is put down.[function cures mainly] wind and heat dispersing, cooling blood for hemostasis.The hot hoarseness of main air, pharyngalgia, edema, spitting of blood, have blood in stool, menorrhagia, knife injury is hemorrhage.
Herba potentillae kleinianae: [source] is the whole herb with root of rosaceous plant Herba potentillae kleinianae Herba Potentillae Chinensis.[nature and flavor] bitter in the mouth, cold in nature.[return through] returns liver, lung meridian.[function cures mainly] heat clearing away is calmed the frightened, and preventing the attack (or recurrence) of malaria, relieving cough and resolving phlegm, removing toxic substances is invigorated blood circulation.Main hyperpyrexia and infantile convulsion, malaria, cough due to lung-heat, pertussis, dysentery, furuncle toxic swelling, laryngopharynx swelling and pain, acute toothache, herpes zoster, conjunctival congestion and swelling pain, worm venom, rheumatic numbness, traumatic injury, menoxenia, traumatic hemorrhage.
Herba Gerberae Piloselloidis: [source] is the herb of feverfew Herba Gerberae Piloselloidis.[nature and flavor] bitter in the mouth, pungent, cool in nature.[function cures mainly] heat-clearing and toxic substances removing, lung qi dispersing cough-relieving, promoting flow of QI and blood.The main cough due to common cold, epigastric distending pain, has loose bowels, dysentery, edema, stranguria with turbid discharge, furuncle toxic swelling, treating swelling and pain by traumatic injury, venom.
Radix epipactinis: [source] is the root of orchid little Hua helleborine.[nature and flavor] are bitter, cold.[return through] returns lung meridian.[function cures mainly] clearing away lung-heat to relieve cough, promoting blood circulation and detoxication.Main cough due to lung-heat, laryngopharynx swelling and pain, toothache, conjunctival congestion and swelling pain, fullness in the chest and hypochondrium is vexed, diarrhoea, lumbago, traumatic injury, venom.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Clinopodii Polycephali 5 ~ 15 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 15 parts, Herba abutili indici 10 ~ 20 parts, Arisaema balansae Engl. grass 15 ~ 25 parts, Serissa foetida 5 ~ 15 parts, Ramulus et folium henslowiae frutescentis 5 ~ 15 parts, rabbit ear grass 15 ~ 25 parts, Radix Saurauiae Tristylae 10 ~ 20 parts, Herba Dracocephali Rupestris 10 ~ 20 parts, Herba Epilobii 15 ~ 25 parts, Herba potentillae kleinianae 25 ~ 35 parts, Herba Gerberae Piloselloidis 45 ~ 55 parts and Radix epipactinis 25 ~ 35 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Clinopodii Polycephali 5 ~ 10 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 10 parts, Herba abutili indici 10 ~ 15 parts, Arisaema balansae Engl. grass 15 ~ 20 parts, Serissa foetida 5 ~ 10 parts, Ramulus et folium henslowiae frutescentis 5 ~ 10 parts, rabbit ear grass 15 ~ 20 parts, Radix Saurauiae Tristylae 10 ~ 15 parts, Herba Dracocephali Rupestris 10 ~ 15 parts, Herba Epilobii 15 ~ 20 parts, Herba potentillae kleinianae 25 ~ 30 parts, Herba Gerberae Piloselloidis 45 ~ 50 parts and Radix epipactinis 25 ~ 30 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Clinopodii Polycephali 6 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 7 parts, Herba abutili indici 12 parts, Arisaema balansae Engl. grass 16 parts, Serissa foetida 8 parts, Ramulus et folium henslowiae frutescentis 7 parts, rabbit ear grass 18 parts, Radix Saurauiae Tristylae 14 parts, Herba Dracocephali Rupestris 11 parts, Herba Epilobii 17 parts, Herba potentillae kleinianae 28 parts, Herba Gerberae Piloselloidis 47 parts and Radix epipactinis 26 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the starch of 0.3 ~ 0.5 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 2 ~ 5cm, soak 3 ~ 6 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 30 ~ 60 minutes dosage to medicinal liquid be slowly 200 ~ 400ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 2 ~ 3cm, soaks 3 ~ 6 hours; 20 ~ 30 minutes dosage to medicinal liquid is 100 ~ 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1 capsule
Get Herba Clinopodii Polycephali 60g, Radix osterici citriodori (Radix Angelicae Citriodorae) 70g, Herba abutili indici 120g, Arisaema balansae Engl. grass 160g, Serissa foetida 80g, Ramulus et folium henslowiae frutescentis 70g, rabbit ear careless 180g, Radix Saurauiae Tristylae 140g, Herba Dracocephali Rupestris 110g, Herba Epilobii 170g, Herba potentillae kleinianae 280g, Herba Gerberae Piloselloidis 470g and Radix epipactinis 260g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 75%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.3 times, the magnesium stearate of 0.005 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is incapsulated in housing, namely obtain capsule finished product.
Embodiment 2 decoction
Get Herba Clinopodii Polycephali 8g, Radix osterici citriodori (Radix Angelicae Citriodorae) 9g, Herba abutili indici 14g, Arisaema balansae Engl. grass 18g, Serissa foetida 5g, Ramulus et folium henslowiae frutescentis 9g, rabbit ear careless 16g, Radix Saurauiae Tristylae 11g, Herba Dracocephali Rupestris 13g, Herba Epilobii 19g, Herba potentillae kleinianae 26g, Herba Gerberae Piloselloidis 49g and Radix epipactinis 28g;
Prepare according to the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 5cm, soak 6 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 60 minutes dosage to medicinal liquid be slowly 400ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 3 hours; The 30 minutes dosage to medicinal liquid is 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>42.4 crude drug/kg, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 606 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 75 routine cases are my Out-patient Department patient of in June, 2011 ~ 2013 year December.Patient is divided into treatment group and matched group at random, and all patients are acute episode of chronic bronchitis phase and chronic persistence patient.Wherein treatment group 38 people, male 23 people, women 15 people, 37 ~ 75 years old age, average (57 ± 5.4) year, the course of disease: 3 years ~ 12 years, average (5.5 ± 1.4) year; Acute attack stage 18 people, chronic persistence 20 people; Simple type 12 people, type of panting 26 people.Matched group 37 people, male 24 people, women 13 people, 36 ~ 75 years old age, average (56 ± 4.5) year, the course of disease: 2 years ~ 11 years, average (5.6 ± 1.8) year; Acute attack stage 16 people, chronic persistence 21 people; Simple type 13 people, type of panting 24 people.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: according to regular higher education 11th Five-Year National planning teaching material, Ministry of Public Health Eleventh-Five Year Plan teaching material " internal medicine " the 7th edition, and in January, 2009 first edition " clinic diagnosis guide-respirology fascicle " diagnostic point write with reference to Chinese Medical Association: (1) clinical chronic or recurrent cough, expectoration or with panting, annual morbidity at least 3 months, and continuous 2 years or more persons.(2) as lasting less than 3 months in fallen ill every year, and have clear and definite objective determination also diagnosable according to (as x-ray, pulmonary function etc.).(3) get rid of other heart, pulmonary disease (as pulmonary tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, pulmonary carcinoma, heart disease, cardiac insufficiency, chronic rhinitis etc.) cause cough, cough with asthma or with panting.
Clinical typing, by stages: according to clinical manifestation, is divided into simple type and type amphitypy of panting by chronic bronchitis.The former main manifestations is recurrent cough, expectoration, and the latter still has wheezing symptoms except cough, expectoration, and with wheezing sound.
According to the course of disease through being divided into for 3 phases: (1) acute attack stage: occurred purulence or mucopurulent sputum in 1 week, amount of expectoration obviously increases, or with the performance of the inflammation such as heating or 1 week interior " coughing ", " expectorant ", " breathing heavily " any one symptom is significantly aggravated or critically ill patient obviously adds severe one.(2) chronic persistence: refer to " coughing ", " expectorant ", " breathing heavily " symptom of having in various degree, delay more than 1 month person.(3) clinical relieving period: refer to through treatment or natural remission, symptom substantially disappears or occasionally has slight cough and a small amount of sputum, keeps more than 2 months persons.
Chinese medical discrimination: phlegm-heat accumulated in the lung type: coughing and wheezing, pharyngalgia, the yellow thickness of expectorant, fullness in the chest is rough, thirst and liking drink, dark coloured urine constipation.Red tongue, yellow and greasy fur, slippery and rapid pulse or big vast number.
Therapeutic Method:
Matched group: each 0.2g of oral hydrochloride levofloxacin capsule, every day 3 times, each 0.1g of oral aminophylline, every day 3 times 10 days was 1 course for the treatment of.
Treatment group: oral each 5 of Chinese medicine embodiment 1 capsule of the present invention, every day 3 times.It within 10 days, is 1 course for the treatment of.
Curative effect judging standard: clinic control: clinical symptoms and physical signs of lung and chest x-ray sign disappear, and Arterial blood gas is remarkable, and secretions amount obviously reduces, cough with asthma transference cure, and pulmonary's rale disappears.Effective: clinical symptoms and physical signs of lung and chest x-ray sign are obviously improved, and Arterial blood gas is good, secretions amount reduces, and cough with asthma symptom alleviates, and pulmonary's rale reduces.Invalid: clinical symptoms and physical signs of lung and chest x-ray sign are without improvement, and even worsen, Arterial blood gas is not obvious, and secretions amount is without change, and even from less to more, cough with asthma symptom is without alleviating, and pulmonary's rale increases.
Therapeutic outcome: see the following form.
| Group | n | Clinic control | Effectively | Invalid | Effectively total |
| Treatment group | 38 | 24 | 11 | 3 | 35(92.11％) |
| Matched group | 37 | 11 | 18 | 8 | 29(78.38％) |
Note: compare P<0.05 with matched group
Concrete case: Chen, male, 59 years old.Patient suffers from chronic bronchitis 6.5 years, type of panting, chronic persistence.Coughing and wheezing, pharyngalgia, the yellow thickness of expectorant, fullness in the chest is rough, thirst and liking drink, dark coloured urine constipation.Red tongue, yellow and greasy fur, slippery and rapid pulse.Syndrome Types of TCM is phlegm-heat accumulated in the lung type chronic bronchitis.Give each 5 of Chinese medicine embodiment 1 capsule of the present invention, every day 3 times, treat 12 days, transference cure, clinic control.Follow up a case by regular visits to and do not recur for 1 year.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat a Chinese medicine for phlegm-heat accumulated in the lung type chronic bronchitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Clinopodii Polycephali, Radix osterici citriodori (Radix Angelicae Citriodorae), Herba abutili indici, Arisaema balansae Engl. grass, Serissa foetida, Ramulus et folium henslowiae frutescentis, rabbit ear grass, Radix Saurauiae Tristylae, Herba Dracocephali Rupestris, Herba Epilobii, Herba potentillae kleinianae, Herba Gerberae Piloselloidis and Radix epipactinis.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Clinopodii Polycephali 5 ~ 15 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 15 parts, Herba abutili indici 10 ~ 20 parts, Arisaema balansae Engl. grass 15 ~ 25 parts, Serissa foetida 5 ~ 15 parts, Ramulus et folium henslowiae frutescentis 5 ~ 15 parts, rabbit ear grass 15 ~ 25 parts, Radix Saurauiae Tristylae 10 ~ 20 parts, Herba Dracocephali Rupestris 10 ~ 20 parts, Herba Epilobii 15 ~ 25 parts, Herba potentillae kleinianae 25 ~ 35 parts, Herba Gerberae Piloselloidis 45 ~ 55 parts and Radix epipactinis 25 ~ 35 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Clinopodii Polycephali 5 ~ 10 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 5 ~ 10 parts, Herba abutili indici 10 ~ 15 parts, Arisaema balansae Engl. grass 15 ~ 20 parts, Serissa foetida 5 ~ 10 parts, Ramulus et folium henslowiae frutescentis 5 ~ 10 parts, rabbit ear grass 15 ~ 20 parts, Radix Saurauiae Tristylae 10 ~ 15 parts, Herba Dracocephali Rupestris 10 ~ 15 parts, Herba Epilobii 15 ~ 20 parts, Herba potentillae kleinianae 25 ~ 30 parts, Herba Gerberae Piloselloidis 45 ~ 50 parts and Radix epipactinis 25 ~ 30 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Clinopodii Polycephali 6 parts, Radix osterici citriodori (Radix Angelicae Citriodorae) 7 parts, Herba abutili indici 12 parts, Arisaema balansae Engl. grass 16 parts, Serissa foetida 8 parts, Ramulus et folium henslowiae frutescentis 7 parts, rabbit ear grass 18 parts, Radix Saurauiae Tristylae 14 parts, Herba Dracocephali Rupestris 11 parts, Herba Epilobii 17 parts, Herba potentillae kleinianae 28 parts, Herba Gerberae Piloselloidis 47 parts and Radix epipactinis 26 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the starch of 0.3 ~ 0.5 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 2 ~ 5cm, soak 3 ~ 6 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 30 ~ 60 minutes dosage to medicinal liquid be slowly 200 ~ 400ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 2 ~ 3cm, soaks 3 ~ 6 hours; 20 ~ 30 minutes dosage to medicinal liquid is 100 ~ 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 150 ~ 250 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 ~ 0.5 times, the starch of 0.3 ~ 0.5 times, the magnesium stearate of 0.005 ~ 0.05 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
The first step: purple casserole is put in described raw medicinal material mixing, adds clear water, to the dipped medical material upper surface of clear water 2 ~ 5cm, soak 3 ~ 6 hours;
Second step: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct 30 ~ 60 minutes dosage to medicinal liquid be slowly 200 ~ 400ml, filters, obtain filtrate a, for subsequent use;
3rd step: residue medicinal residues are added clear water again, to the dipped medical material upper surface of clear water 2 ~ 3cm, soaks 3 ~ 6 hours; 20 ~ 30 minutes dosage to medicinal liquid is 100 ~ 300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
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| CN105381265A (en) * | 2015-12-30 | 2016-03-09 | 吴嫱 | Traditional Chinese medicine for treating phlegm-heat obstructing lung obstructive emphysema and preparing method |
| CN105727144A (en) * | 2016-04-03 | 2016-07-06 | 张鸿 | Traditional Chinese medicine composition for treating bronchitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105381265A (en) * | 2015-12-30 | 2016-03-09 | 吴嫱 | Traditional Chinese medicine for treating phlegm-heat obstructing lung obstructive emphysema and preparing method |
| CN105727144A (en) * | 2016-04-03 | 2016-07-06 | 张鸿 | Traditional Chinese medicine composition for treating bronchitis and preparation method thereof |
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