CN108815339A - The Chinese medicine composition and preparation for treating urarthritis and/or hyperuricemia - Google Patents
The Chinese medicine composition and preparation for treating urarthritis and/or hyperuricemia Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition for treating urarthritis and/or hyperuricemia, is prepared You Bi Collettii, Desmodium styracifolium, Lygodium japonicum, cudrania root, endothelium corneum gigeriae galli, pyrrosia lingua, motherwort, Asiatic plantain, radix achyranthis bidentatae, Poria cocos, the dried immature fruit of citron orange；Chinese medicine composition of the invention is prepared by several kinds of Chinese medicinal materials, is had the effects of dehumidifying diuresis, activating blood circulation and reducing swelling, eliminating blood stasis and smoothing collaterals, kidney-supplementing liver-boosting, strengthening muscles and bones, can effectively be treated urarthritis and/or hyperuricemia；Chinese medicine composition of the invention may also be fabricated which the several formulations such as capsule, granule, oral solution, takes, is easy to carry, and the sufferer for meeting the different patient's condition is taken and carried, wide application of the crowd；In addition, Traditional Chinese medicine composition formula of the invention is scientific and reasonable, Small side effects, preparation method is simple, and preparation cost is low, can mitigate body and the financial burden of patient significantly, has very big promotional value.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese medicine for treating urarthritis and/or hyperuricemia
Composition and its preparation.
Background technique
Gout is since disorders of purine metabolism, uric acid generate excessive or lead to urea liter in blood because uric acid excretion is bad
High, urate crystal is deposited on caused redness and swelling of joints heat pain recurrent exerbation in synovium of joint, synovial bursa, cartilage and its hetero-organization
Chronic, systemic disease.Clinical characters be hyperuricemia, acute gouty arthritis recurrent exerbation, tophus formed, it is chronic
Arthritis and joint deformity, and there is calculus urate and gouty parenchymal lesion of the kidney in the course of disease later period.
Hyperuricemia is a kind of purine metabolism disease, is a kind of body that uric acid in blood concentration exceeds normal range (NR)
State is (it is generally acknowledged that 420 μm of olL of blood uric acid >-1, i.e. 7 μ gmL-1When be hyperuricemia), be the premise and life of gout
Change basis.
Urarthritis is that Monosodium urate crystalline solid deposits to the poor joint part initiation joint and its pass of blood circulation
There is the inflammatory reaction of aseptic, mostly acute attack in section surrounding tissue, and pain is more violent, and pain is confined to joint portion more
Position seriously affects the basic function in joint, and then the holistic health for influencing body is horizontal.
The pathogenesis of urarthritis is more complicated, mainly since abnormal, uric acid occurs in the purine metabolism of body
Excretion there is abnormal, blood uric acid and persistently increase, generate a large amount of Monosodium urate crystallization so as to cause body.Urate crystal body can
To be flowed in the circulatory system of body, poor position is recycled when lithate is recycled to body blood, will deposit, draw
It plays joint and exception occurs in surrounding tissue, or even cause the limitation of activity in joint, influence the normal function in joint.
Motherland's medicine thinks that gout belongs to the range of " rheumatism ", referred to as " severe and migratory arthralgia ", " fire toxin " etc..Its cause of disease is：Element
The body overabundance of yang, in addition usually overfeeding fatness, sweet, thick and oily, retention of damp-heat in the interior block channels and collaterals and stay note joint, heat strongly fragrant for poison therefore red and swollen heat pain, wet poison
It stays for a long time and does not go, invest joint, form subcutaneous nodule, as hard as flint is the main reason for forming tophus.Turbid poison subcutaneous nodule is stopped up amenorrhoea network and is closed
Section, QI-blood circulation are obstructed, and general rule pain hair is not sick thus.Affection of exogenous wind-cold damp evil invades human muscle's tendon and vessel, stays for a long time and do not go, block
Passages through which vital energy circulates, long strongly fragrantization fire.As《Jing Yue's complete work tinea pedis》It " is cold sensation of the genitalia water-wet outside, modern damp evil attacks people's flesh tendon；It is interior by usually fertile
It is sweet excessive, it is burnt under wet heap soil or fertilizer over and around the roots；It is cold mutually to be tied with damp evil strongly fragrant and change heat, skin is stopped, diseased region redness hectic fever, then bone loses long ".《Class
Disease controls sanction》Middle record：" gout, one of arthritis disease then change thermotropic pain, until Night Watch is acute just because of the wet Yu Biyin of chill points long ".It
Be disease incidence compared with high, disability rate compared with high, harmfulness is big, be worldwide common difficult disease.There are blood by China at least 2.5 hundred million people
The excessively high crowd of uric acid has nearly 80,000,000 patient with gout effectively cannot treat or treat every year and is not thorough, leads to the state of an illness not
It is disconnected to deteriorate, it is forced to dysarthrasis, or even disabled edge, is just suffering from the pain constricted of gout.As our people lives
Horizontal raising eating habit causes gout disease incidence increasing, severely impacts the holistic health of our people, it is seen that I
State is the morbidity big country of goat.
Clinical treatment gout is mainly administered according to symptom, eats colchicin in stage of attack and adds anodyne, so as to quick
Anti-inflammatory releases pain, and the intermittent phase, which eats the drugs such as other purine, reduces uric acid, and prevention breaks out again.Western medicine pair used in gout at present
Effect is big, palliative.In addition, taking anti-trioxypurine Western medicine in the intermittent phase, rebound after drug withdrawal very fast, and as urine
Acid dissolution is too fast and causes the breaking-out of metastatic gout.Traditional Chinese medicine treat this disease with toxic reaction small, advantage for the treatment of both manifestation and root cause of disease,
Symptom can be improved in acute stage and adjust viscera function in chronic phase and paracmasis, balanced body negative and positive of qi and blood, reduce
Recurrence.Therefore, how one kind is provided and takes safe and free of toxic and side effects, effective treatment urarthritis and/or hyperuricemia
Chinese medicine composition be those skilled in the art's urgent problem to be solved.
Summary of the invention
It is an object of the invention to overcome defect of the existing technology, provide it is a kind of treat urarthritis and/or
The Chinese medicine composition and its preparation of hyperuricemia.
To achieve the goals above, the technical solution adopted by the present invention is as follows：
The Chinese medicine composition for the treatment of urarthritis and/or hyperuricemia of the invention, by the original of following parts by weight
What material was prepared：10-30 parts of Bi Collettii, 15-45 parts of Desmodium styracifolium, 15-45 parts of Lygodium japonicum, 7-23 parts of cudrania root, endothelium corneum gigeriae galli 7-
23 parts, 5-15 parts of pyrrosia lingua, 7-25 parts of motherwort, 15-45 parts of Asiatic plantain, 5-15 parts of radix achyranthis bidentatae, 7-25 parts of Poria cocos, 5-15 parts of the dried immature fruit of citron orange.
Preferably, it is prepared by the raw material of following parts by weight：20 parts of Bi Collettii, 30 parts of Desmodium styracifolium, 30 parts of Lygodium japonicum,
15 parts of cudrania root, 15 parts of endothelium corneum gigeriae galli, 10 parts of pyrrosia lingua, 15 parts of motherwort, 30 parts of Asiatic plantain, 10 parts of radix achyranthis bidentatae, 15 parts of Poria cocos, the dried immature fruit of citron orange 10
Part.
It is the crude drug source of the traditional chinese medicine composition of the invention below：
Bi Collettii, entitled Dioscorea collettii Hook.f.var.hypoglauca (Palibin) the P é i et of Latin
Ting., the stem tuber of Chinese yam, fork stamen Chinese yam, Shan Bi Collettii or very thin Chinese yam etc. is carried on the back for Dioscoreaceae Plant Powder.Hardship is put down.Wind-dispelling, dampness removing.
Control rheumatoid arthritis stubborn, lumbocrural pain, difficult urination, stranguria with turbid discharge, spermatorrhea, damp and hot sore.
Desmodium styracifolium is the dry ground of leguminous plant Desmodium styracifolium Desmodium styracifolium (Osh.) Merr.
Upper part.It is sweet, light, it is cool.Removing damp-heat, inducing diuresis for treating strangurtia.For heat gonorrhea, sand leaching, urolithiasis, difficulty and pain in micturition, edema and little urine, jaundice urine
It is red, lithangiuria.
Lygodium japonicum is the drying and ripening spore of Lygodiaceae plant Lygodium japonicum Lygodiumjaponicum (Thunb.) Sw.
Son.It is sweet, salty, it trembles with fear.Eliminating dampness and heat, treating stranguria analgesic.For heat gonorrhea, urolithiasis, blood strangury, cream leaching, Urethra astringent pain.
Cudrania root, Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et
Masam., it is used as medicine with root.Slight bitter is put down.It is relieving cough and reducing sputum, expelling wind and removing dampness, removing blood stasis and acesodyne.For pulmonary tuberculosis, icteric hepatitis, liver and spleen
Enlargement, taste-blindness rate, rheumatic lumbocrural pain；Fracture, traumatic injury are controlled in external application.
Endothelium corneum gigeriae galli is the drying inner wall of sandbag of Phasianidae animal family chicken Gallus gallus domesticus Brisson.
Sweet and neutral.Stomach strengthening and digestion promoting, arresting seminal emission.For dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, spermatorrhea.
Pyrrosia lingua is Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, pyrrosia lingua Pyrrosia
The dried leaf of lingua (Thunb.) Farwell or pyrrosia petiolosaChing Pyrrosiapetiolosa (Christ) Ching.It is sweet, bitter,
It is slightly cold.Inducing diuresis for treating strangurtia, clearing away heat to stop bleeding.For heat gonorrhea, blood strangury, urolithiasis, urinary obstruction, leaching drips puckery pain, spits blood, and bleeding from five sense organs or subcutaneous tissue, hematuria collapses
Leakage, dyspnea and cough due to lung-heat.
Motherwort is the fresh of Lamiaceae plant motherwort Leonurusjaponicus Houtt. or dry overground part
Point.It is bitter, pungent, it is slightly cold.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.For irregular menstruation, dysmenorrhea, menostasis, lochiorrhagia, edema and little urine；It is acute
Nephritic dropsy.
Asiatic plantain is plantago plant Chinese herbaceous peony Plantago asiatica L. or ordinary building Plantago depressa
Willd. drying herb.It is sweet, it trembles with fear.Reducing fever and causing diuresis, eliminating the phlegm, cool blood, removing toxic substances.For edema and little urine, puckery pain of heat gonorrhea, summer-heat and damp is rushed down
Dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Radix achyranthis bidentatae is the dry root of amaranthaceous plant radix achyranthis bidentatae Achyranthes bidentataBlume..Bitter, acid, puts down.Tonifying liver
Kidney, strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow are ensuringd proper downward flow of the blood.For soreness of waist and knee joint, muscles and bones is powerless, menostasis abdominal mass, dizziness due to hyperactivity of liver-YANG.
Poria cocos is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf.It is sweet, light, it puts down.Li Shui
Excreting dampness, invigorating the spleen calming heart.For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
The dried immature fruit of citron orange is rutaceae bitter orange Citrus aurantium L. and its variety or sweet orange Citrus
The drying young fruit of sinensis Osbeck.It is bitter, pungent, sour, temperature.Relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass.For internal stagnation, feeling of fullness is swollen
Bitterly, weight after rush down dysentery, constipation, phlegm stagnant gas hinder thoracic obstruction, accumulation of pathogens in chest；Gastroptosis, rectal prolapse, uterine prolapse.
It is a further object of the present invention to provide the preparation method of the active constituent of the traditional chinese medicine composition of the invention, this method is to adopt
It is mentioned with water or the extraction of the ethyl alcohol of 40-70% concentration expressed in percentage by volume is prepared.Specific preparation method is as follows：
Scheme one：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated 70-80 DEG C
1.20 clear cream is to get active constituent.
Scheme two：Whole medicinal materials are taken, are extracted 2-3 times after mixing with 40-70% alcohol reflux, each ethanol consumption is medicinal material
4-10 times of total weight, extraction time are 1-4 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.05-1.20 clear cream to get active constituent.
Scheme three：Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated into 70-80 DEG C
Ethyl alcohol is added in 1.20 clear cream, makes alcohol content 40-70%, stands 12-24 hours, filtering, when filtrate is concentrated into 70-80 DEG C
Relative density is the medicinal extract of 1.05-1.20 to get active constituent.
The Chinese medicine composition for the treatment of urarthritis and/or hyperuricemia of the present invention, can also be with medicine
Various preparations, such as tablet, capsule, oral solution, syrup, mixture, granule is made in acceptable carrier combination on.
Pharmaceutically acceptable carrier of the invention includes but is not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethyl alcohol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrating agent：Starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethyl alcohol, glycerol, propylene glycol, liquid paraffin, vegetable oil etc..
Corrigent：Sucrose, monosaccharide, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1：Tablet
It takes scheme one one of to three gained active constituent of scheme, tablet is added and often uses auxiliary material, routinely prepared by production method
Obtain Tablets.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 2：Capsule
It takes scheme one one of to three gained active constituent of scheme, capsule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 3：Syrup
It takes scheme one one of to three gained active constituent of scheme, syrup is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain syrup of the present invention.
Above-mentioned syrup often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 4：Mixture
It takes scheme one one of to three gained active constituent of scheme, mixture is added and often uses auxiliary material, routinely prepared by production method
Obtain mixture of the present invention.
Above-mentioned mixture often includes one of corrigent, preservative or whole with auxiliary material.
Method 5：Oral solution
Take scheme one one of to three gained active constituent of scheme, dissolution after-purification, concentration are added oral solution and often use auxiliary material,
Routinely production method is prepared into oral solution of the present invention.
Above-mentioned oral solution often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 6：Granule
It takes scheme one one of to three gained active constituent of scheme, granule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain granule of the present invention.
Above-mentioned granule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
The applicant combines Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research achievement to compare by many years development test
The Chinese medicine composition for the effects of multiple formulations obtain with expelling wind and removing dampness, scattered stasis pain, The strong bone of kidney tonifying, clearing away heat to stop bleeding.The present invention
Chinese medicine composition using Bi Collettii as monarch drug in a prescription,《Sheng Nong's herbal classic》Middle record Bi Collettii " it is strong to cure mainly lumbago, joint chill is wet, week
Numbness, malignant sore not Treatment, hot gas ",《Japan hanako materia medica》It is middle record its " control carbuncle delay light air, head rotation, epilepsy disease, moisturizing hiding, hard muscles and bones, benefit
Essence, improving eyesight, apoplectic aphasia ",《Jing Yue's complete work》Yun Bi Collettii " controls quadriplegia not with whole body rheumatism malignant sore.Nature and flavor are pure slow, with suitable
Big agent ".It is our using Bi Collettii as monarch drug in a prescription, dampness removing removes turbid, wind expelling stagnation removing, separating clear and excreting turbid.With Desmodium styracifolium, Lygodium japonicum, endothelium corneum gigeriae galli, wear
Broken stone, pyrrosia lingua are ministerial drug, Desmodium styracifolium, Lygodium japonicum and stone reed removing damp-heat, inducing diuresis for treating strangurtia, cudrania root expelling wind and removing dampness, and the scattered stasis of blood is stopped
Bitterly, endothelium corneum gigeriae galli is mild-natured, can arresting seminal emission, this four traditional Chinese medicine is total to principal drug assistance and reinforces clearing heat and detoxicating, function that treating stranguria row is turbid.With Poria cocos, vehicle
Preceding grass, motherwort, the dried immature fruit of citron orange are adjutant, Poria cocos clearing damp and promoting diuresis, invigorating the spleen calming heart, Asiatic plantain reducing fever and causing diuresis, eliminating the phlegm removing toxic substances, motherwort work
Blood, inducing diuresis to remove edema, dried immature fruit of citron orange relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass, the above four traditional Chinese medicine assistant principal drug assistance and ministerial drug promoting blood circulation, dissipate the stasis of blood, dredging collateral, light infiltration
Li Shui.It is to make medicine with radix achyranthis bidentatae, dispelling stasis of blood and stimulating the menstrual flow, strong pelvic bone, inducing diuresis for treating strangurtia, is ensuringd proper downward flow of the blood at nourishing liver and kidney.Dehumidifying diuresis is played altogether by full side,
Activating blood circulation and reducing swelling, eliminating blood stasis and smoothing collaterals, kidney-supplementing liver-boosting, the function of strengthening muscles and bones promote blood circulation and uric acid metabolism, reduce urate crystal
The generation of body and urate crystal body reduce uric acid in blood content, effectively treat hyperuricemia and pain in intra-articular deposition
Wind arthritis.
The present invention is by adopting the above-described technical solution, have the advantages that：
(1) Chinese medicine composition of the invention and its preparation are prepared by several kinds of Chinese medicinal materials, and safety is mild, are made to human body pair
With minimum, have the effects of dehumidifying diuresis, activating blood circulation and reducing swelling, eliminating blood stasis and smoothing collaterals, kidney-supplementing liver-boosting, strengthening muscles and bones , Bi Collettii dampness removing go it is turbid, dispel
Wind eliminating impediment, separating clear and excreting turbid promote uric acid metabolism, reduce uric acid and accumulate and reduce in blood urate crystal body in joint
Deposition；Desmodium styracifolium, Lygodium japonicum and stone reed removing damp-heat, inducing diuresis for treating strangurtia, cudrania root expelling wind and removing dampness, removing blood stasis and acesodyne, endothelium corneum gigeriae galli can
The effect of arresting seminal emission, clearing heat and detoxicating, the treating stranguria row for improving Bi Collettii is turbid；Poria cocos clearing damp and promoting diuresis, invigorating the spleen calming heart, Asiatic plantain heat-clearing benefit
Urine, eliminating the phlegm removing toxic substances, motherwort promoting blood circulation, inducing diuresis to remove edema, dried immature fruit of citron orange relieving stagnant Qi disperse accumulation, eliminating phlegm and dispersing mass, the promoting blood circulation of this four traditional Chinese medicine, the scattered stasis of blood, dredging collateral,
Promoting diuresis with drugs of tasteless flavour promotes blood circulation, and the drug effect of the medicinal materials such as assistant Zhu Bi Collettii, Desmodium styracifolium plays；Radix achyranthis bidentatae dispelling stasis of blood and stimulating the menstrual flow, draws under blood
The pharmacological property of the clearing damp diuresis of remaining medicinal material is further introduced lower coke, drug is made accurately to act on hair by row, nourishing liver and kidney, strengthening the bones and muscles
Sick position, but can liver-kidney tonifying, can dampness removing go turbid, and be avoided that kidney load is excessive.Dehumidifying diuresis is played altogether by full side, and promoting blood circulation disappears
Swollen, eliminating blood stasis and smoothing collaterals, kidney-supplementing liver-boosting effectively treats urarthritis and hyperuricemia.
(2) Chinese medicine composition of the invention and its preparation clinical tests prove that, Chinese medicine composition of the invention is to simple
The cure rate of urarthritis is 11.5%, total effective rate 90.5%；Cure rate to simple hyperuricemia is
12.7%, total effective rate 90.5%；It is 14.0% to the cure rate for merging urarthritis and hyperuricemia, it is total effective
Rate is 91.2%.It can be seen that the traditional chinese medicine composition of the invention and its preparation can effectively treat urarthritis and antihyperuricemic
Disease, showing patient by clinical observation generally can feel that arthralgia is substantially reduced or disappears after 1 course for the treatment of of taking medicine, curative effect
It is significant rapidly, and the Liver and kidney function and hemopoietic system of patient are had no abnormal changes and adverse reaction, the state of an illness does not go out after drug withdrawal
Existing " rebound ", clinic are taken securely and reliably.
(3) several formulations are made in Chinese medicine composition of the invention, take, is easy to carry, meet the sufferer clothes of the different patient's condition
With and carry, wide application of the crowd.
(4) Chinese medicine composition of the invention and its pharmaceutical formulation are scientific and reasonable, and Small side effects, preparation method is simple, preparation
It is at low cost, body and the financial burden of patient can be mitigated significantly, there is very big promotional value.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, preferred embodiment is enumerated below, to this hair
Bright further description.However, it is necessary to illustrate, many details listed in specification are used for the purpose of making reader to this
The one or more aspects of invention have a thorough explanation, also may be implemented even without these specific details of the invention
These aspects.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v indicates the volume of solution
Than.
1 tablet of embodiment
It is female to weigh Bi Collettii 10kg, Desmodium styracifolium 15kg, Lygodium japonicum 15kg, cudrania root 7kg, endothelium corneum gigeriae galli 7kg, pyrrosia lingua 5kg, benefit
Careless 7kg, Asiatic plantain 15kg, radix achyranthis bidentatae 5kg, Poria cocos 7kg, dried immature fruit of citron orange 5kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 10 times, and two
Secondary extraction time is respectively 3 hours, 2 hours, combined extract, filtering, when filtrate is concentrated 70 DEG C relative density be 1.10 it is clear
Additive of tablet Icing Sugar, ethyl alcohol, gelatin, crospovidone, talcum powder is added in cream, and routinely tablet is made in scheme.
2 tablet of embodiment
It is female to weigh Bi Collettii 12kg, Desmodium styracifolium 18kg, Lygodium japonicum 18kg, cudrania root 9kg, endothelium corneum gigeriae galli 9kg, pyrrosia lingua 6kg, benefit
Careless 8kg, Asiatic plantain 19kg, radix achyranthis bidentatae 7kg, Poria cocos 9kg, dried immature fruit of citron orange 6kg；
Whole medicinal materials are taken, are extracted 3 times after mixing with 40% alcohol reflux, each ethanol consumption is the 10 of medicinal material total weight
Again, 8 times, 6 times, extraction time is respectively 4 hours, 2 hours, 1 hour three times, and combined extract filters, and filtrate is concentrated into 70 DEG C
When relative density be 1.05 clear cream, be added additive of tablet lactose, polyethylene glycol, starch, magnesium stearate, routinely scheme be made
Tablet.
3 capsule of embodiment
Weigh Bi Collettii 15kg, Desmodium styracifolium 22kg, Lygodium japonicum 23kg, cudrania root 11kg, endothelium corneum gigeriae galli 10kg, pyrrosia lingua 8kg, benefit
Brittle Falsepimpernel Herb 10kg, Asiatic plantain 21kg, radix achyranthis bidentatae 10kg, Poria cocos 12kg, dried immature fruit of citron orange 7kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 8 times, often
Secondary extraction time is respectively 3 hours, 2 hours, and combined extract, filtering, relative density is 1.10 when filtrate is concentrated into 70 DEG C
Ethyl alcohol is added in clear cream, makes alcohol content 40%, stands 12 hours, filtering, and relative density is 1.05 when filtrate is concentrated into 70 DEG C
Capsule auxiliary material dextrin, cellulose derivative, ethyl alcohol, sodium carboxymethyl starch, talcum powder is added in medicinal extract, and routinely scheme is made
Capsule.
4 capsule of embodiment
Weigh Bi Collettii 17kg, Desmodium styracifolium 25kg, Lygodium japonicum 26kg, cudrania root 14kg, endothelium corneum gigeriae galli 12kg, pyrrosia lingua 10kg,
Motherwort 12kg, Asiatic plantain 24kg, radix achyranthis bidentatae 12kg, Poria cocos 15kg, dried immature fruit of citron orange 9kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 10 times of medicinal material total weight, 7 times, 6
Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, combined extract, filtering, relative density when filtrate is concentrated 77 DEG C
For 1.16 clear cream, capsule microcrystalline cellulose excipients, cellulose derivative, crospovidone, micro mist silicon are added in clear cream
Glue, polyethylene glycol, routinely capsule is made in scheme.
5 syrup of embodiment
Weigh Bi Collettii 18kg, Desmodium styracifolium 27kg, Lygodium japonicum 28kg, cudrania root 15kg, endothelium corneum gigeriae galli 14kg, pyrrosia lingua 12kg,
Motherwort 14kg, Asiatic plantain 28kg, radix achyranthis bidentatae 14kg, Poria cocos 16kg, dried immature fruit of citron orange 10kg；
Whole medicinal materials are taken, are extracted 3 times after mixing with 50% alcohol reflux, each ethanol consumption is 8 times of medicinal material total weight,
5 times, 4 times, each extraction time are respectively 3 hours, 1 hour, 1 hour, combined extract, filtering, when filtrate is concentrated into 75 DEG C
Syrup auxiliary material sucrose, benzoic acid and water are added in clear cream, stirs evenly for the clear cream that relative density is 1.08, and syrup is made
Agent.
6 mixture of embodiment
Weigh Bi Collettii 20kg, Desmodium styracifolium 30kg, Lygodium japonicum 30kg, cudrania root 15kg, endothelium corneum gigeriae galli 15kg, pyrrosia lingua 10kg,
Motherwort 15kg, Asiatic plantain 30kg, radix achyranthis bidentatae 10kg, Poria cocos 15kg, dried immature fruit of citron orange 10kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 10 times of medicinal material total weight, 7 times, 6
Times, each extraction time is respectively 3 hours, 1 hour, 1 hour, and combined extract, filtering, filtrate is concentrated into relatively close at 74 DEG C
Ethyl alcohol is added in the clear cream that degree is 1.14, makes alcohol content 59%, stands 20 hours, and filtering, filtrate is concentrated into relatively close at 75 DEG C
Mixture auxiliary material monosaccharide, sorbic acid are added in medicinal extract, stirs evenly for the medicinal extract that degree is 1.12, and mixture is made.
7 oral solution of embodiment
Weigh Bi Collettii 23kg, Desmodium styracifolium 36kg, Lygodium japonicum 37kg, cudrania root 18kg, endothelium corneum gigeriae galli 19kg, pyrrosia lingua 12kg,
Motherwort 19kg, Asiatic plantain 35kg, radix achyranthis bidentatae 12kg, Poria cocos 17kg, dried immature fruit of citron orange 12kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 10 times of medicinal material total weight, 8 times, 6
Times, each extraction time is respectively 3 hours, 2 hours, 1 hour, combined extract, filtering, relative density when filtrate is concentrated 80 DEG C
For 1.20 clear cream, oral solution auxiliary material aromatic, methyl esters and water are added in clear cream, stirs evenly, dispense, oral solution is made.
8 granule of embodiment
Weigh Bi Collettii 26kg, Desmodium styracifolium 41kg, Lygodium japonicum 42kg, cudrania root 20kg, endothelium corneum gigeriae galli 22kg, pyrrosia lingua 14kg,
Motherwort 23kg, Asiatic plantain 40kg, radix achyranthis bidentatae 14kg, Poria cocos 21kg, dried immature fruit of citron orange 15kg；
Whole medicinal materials are taken, are extracted 2 times after mixing with 70% alcohol reflux, each ethanol consumption is 6 times of medicinal material total weight,
4 times, extraction time is respectively 2 hours, 1 hour, and combined extract, filtering, relative density is 1.20 when filtrate is concentrated into 80 DEG C
Clear cream, be added supplementary product starch, ethyl alcohol, sodium carboxymethyl starch, polyethylene glycol in clear cream, granulation, dry, whole grain are made
Granula.
9 granule of embodiment
Weigh Bi Collettii 30kg, Desmodium styracifolium 45kg, Lygodium japonicum 45kg, cudrania root 23kg, endothelium corneum gigeriae galli 23kg, pyrrosia lingua 15kg,
Motherwort 25kg, Asiatic plantain 45kg, radix achyranthis bidentatae 15kg, Poria cocos 25kg, dried immature fruit of citron orange 7kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 6 times, often
Secondary extraction time is 3 hours, 2 hours, and combined extract filters, the clear cream that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Ethyl alcohol is added, makes alcohol content 70%, stands 24 hours, filtering, the medicinal extract that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Microcrystalline cellulose excipients, water, polyethylene glycol, crospovidone, magnesium stearate, granulation, dry, whole grain, system are added in medicinal extract
Obtain granule.
Clinical test is summarized
1, basic document
Selection is diagnosed as patient 255 of gout, wherein urarthritis 78, hyperuricemia 63, merges pain
Wind arthritis and hyperuricemia 114；The oldest person 68 years old, reckling 23 years old, average age 38.2 years old；Course of disease 0.5-
27 years.Exclude gestation and breast feeding women, those who are allergic to this drug, severe cardiac pulmonary dysfunction, non-coronary disease characteristic of disease heart disease, kidney
Disease, hypertension, stomach patient.
2, diagnostic criteria
It is promulgated within 2012 referring to Department of Medical Administration of State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》Middle gout
Diagnosis basis, disease classification, the classification of efficacy evaluation progress treatment results.
3, treatment method
It is given and is treated using the granule of the embodiment of the present invention 9,2 times a day, each 10g, 14 days as a treatment course.
4, curative effect judging standard
It cures：The clinical symptoms such as redness and swelling of joints heat pain disappear, and functional activity is normal, and blood uric acid is down to normal range (NR).
It is effective：The clinical symptoms such as redness and swelling of joints heat pain disappear substantially, and functional activity is normal, 80% or more blood uric acid drop.
Effectively：The clinical symptoms such as redness and swelling of joints heat pain improve 50% or more, 50% or more blood uric acid decline.
In vain：Symptom is not improved, and blood uric acid and every clinical indices are not improved.
5, result
By the treatment of 3 courses for the treatment of, clinical efficacy is shown in Table 1.
1 therapeutic effect of table
As it can be seen from table 1 the treatment by 3 courses for the treatment of, Chinese medicine composition of the invention is to simple urarthritis
Cure rate be 11.5%, total effective rate 90.5%；Cure rate to simple hyperuricemia is 12.7%, and total effective rate is
90.5%；It is 14.0% to the cure rate for merging urarthritis and hyperuricemia, total effective rate 91.2%.It can be seen that
Invention Chinese medicine composition and its preparation can effectively treat urarthritis and hyperuricemia, show by clinical observation
Patient can generally feel that arthralgia is substantially reduced or disappears after 1 course for the treatment of of taking medicine, and curative effect is significant rapidly, and to patient's
Liver and kidney function and hemopoietic system have no abnormal changes and adverse reaction, and " rebounding " does not occur in the state of an illness after drug withdrawal, and clinic takes peace
It is complete reliable.
Typical case
Case 1：King XX, male, 30 years old.
Main suit：Gout medical history 4 years, because of feed seafood and beer, next day left foot thumb joint congestion and swelling pain, warp before two weeks
Colchicin, indomethacin Treat Temple inside are effective, but effect is not very obvious, and had a blood test heavy 54mm/h, blood uric acid 519umol/L, urea nitrogen
3.9mmol/L, inosine 120umol/L, triglycerides 2.9mmol/L, total cholesterol 6.4mmol/L, HDL1.5mmol/L,
LDL5.2mmol/L.1 course for the treatment of of capsule of the embodiment of the present invention 3 is taken, swelling and pain are subsided, and walking is freely；Continue to take 3 treatments
Journey consolidates curative effect, and have a blood test heavy 14mm/h, blood uric acid 401umol/L, urea nitrogen 3.2mmol/L, inosine 91umol/L, triglycerides
1.5mmol/L, total cholesterol 5.3mmol/L, HDL1.1mmol/L, LDL3.7mmol/L.Follow-up is not recurred after being discontinued 1 year.
Case 2：X is opened, it is male, 50 years old.
Main suit：Before patient 8 years without obvious inducement burst Metatarsophalangeal joint redness invite it is swollen, with night fall ill it is common, continue
Voluntarily alleviate after a couple of days, after gradually involve toe and refer to each joint, while with joint function disturbance, whens panic attacks, cannot be bent and stretched, once
It goes to a doctor in local hospital and is diagnosed as " gout ", usually irregularly take sodium bicarbonate piece, Allopurinol, patient articular's swelling is gradually tight
Weight, joint deformity are hardened.Had a blood test uric acid 650uoml/L, is diagnosed as hyperuricemia.Take 5 syrup 1 of the embodiment of the present invention
A month, all diseases mitigated；It even served 2 months again and consolidate curative effect, all symptoms disappear, checks blood uric acid 395uoml/L, follow-up after half a year of being discontinued
It does not recur.
Case 3：Wu X, female, 65 years old.
Main suit：Night burst left foot big toe pain after patient ate seafood before 1 year, part is red and swollen, the heat of touching.In local hospital
Medical to see that left foot Metatarsophalangeal joint is red, swollen, hot, pain, limitation of activity is thirsty, and restlessness with opprssive feeling and worry, scanty drak urine, tongue is red, yellow tongue fur
It is greasy, wiry and rolling pulse number.Had urine examined sour 553umol/L.Doctor trained in Western medicine is diagnosed as gout, belongs to the acute arthritis phase.Differential diagnosis in tcm：Damp-heat arthralgia resistance
Card.Take the oral solution of the embodiment of the present invention 72 months, arthralgia is substantially reduced；Continue to take 3 course for the treatment of, arthralgia disappears
It loses, freely, uric acid 259umol/L is diagnosed as healing for walking.Follow-up is without recurrence after being discontinued 1 year.
Claims (7)
1. the Chinese medicine composition for treating urarthritis and/or hyperuricemia, which is characterized in that by the original of following parts by weight
What material was prepared：10-30 parts of Bi Collettii, 15-45 parts of Desmodium styracifolium, 15-45 parts of Lygodium japonicum, 7-23 parts of cudrania root, endothelium corneum gigeriae galli 7-
23 parts, 5-15 parts of pyrrosia lingua, 7-25 parts of motherwort, 15-45 parts of Asiatic plantain, 5-15 parts of radix achyranthis bidentatae, 7-25 parts of Poria cocos, 5-15 parts of the dried immature fruit of citron orange.
2. the Chinese medicine composition for the treatment of urarthritis according to claim 1 and/or hyperuricemia, feature exist
In being prepared by the raw material of following parts by weight：20 parts of Bi Collettii, 30 parts of Desmodium styracifolium, 30 parts of Lygodium japonicum, 15 parts of cudrania root,
15 parts of endothelium corneum gigeriae galli, 10 parts of pyrrosia lingua, 15 parts of motherwort, 30 parts of Asiatic plantain, 10 parts of radix achyranthis bidentatae, 15 parts of Poria cocos, 10 parts of the dried immature fruit of citron orange.
3. the Chinese medicine composition for the treatment of urarthritis according to claim 1 or 2 and/or hyperuricemia, special
Sign is：Its active constituent be using water mention or the ethyl alcohol of 40-70% concentration expressed in percentage by volume extraction be prepared.
4. the Chinese medicine composition for the treatment of urarthritis according to claim 3 and/or hyperuricemia, feature exist
In its active constituent is made of being prepared by the following method：Whole medicinal materials are taken, extracting in water 2-3 times after mixing adds every time
Water is equivalent to 6-12 times of medicinal material total weight, and each extraction time is 1-3 hours, combined extract, filtering, and filtrate is concentrated into
Relative density is the clear cream of 1.10-1.20 to get active constituent at 70-80 DEG C.
5. the Chinese medicine composition for the treatment of urarthritis according to claim 3 and/or hyperuricemia, feature exist
In its active constituent is made of being prepared by the following method：Whole medicinal materials are taken, are mentioned after mixing with 40-70% alcohol reflux
It takes 2-3 times, each ethanol consumption is 4-10 times of medicinal material total weight, and extraction time is 1-4 hours, and combined extract filters, filter
Relative density is the clear cream of 1.05-1.20 to get active constituent when liquid is concentrated into 70-80 DEG C.
6. the Chinese medicine composition for the treatment of urarthritis according to claim 3 and/or hyperuricemia, feature exist
In its active constituent is made of being prepared by the following method：Whole medicinal materials are taken, extracting in water 2-3 times after mixing adds every time
Water is equivalent to 6-12 times of medicinal material total weight, and each extraction time is 1-3 hours, combined extract, filtering, and filtrate is concentrated into
Relative density is the clear cream of 1.10-1.20 at 70-80 DEG C, and ethyl alcohol is added, and makes alcohol content 40-70%, stands 12-24 hours,
Filtering, relative density is the medicinal extract of 1.05-1.20 to get active constituent when filtrate is concentrated into 70-80 DEG C.
7. a kind of Chinese materia medica preparation for treating urarthritis and/or hyperuricemia, by any one of claims 1 or 2 or 4-6
The Chinese medicine composition of the treatment urarthritis and/or hyperuricemia and pharmaceutically acceptable carrier combination system
It is standby to form.
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