CN104971271A - Medicine for treating benign prostatic hyperplasia due to damp-retained heat and preparation method thereof - Google Patents
Medicine for treating benign prostatic hyperplasia due to damp-retained heat and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating benign prostatic hyperplasia due to damp-retained heat and a preparation method thereof. The medicine is prepared from the following medicinal raw materials: partedleaf violet herb, botrypus virginianus, selfheal, cichory, lygodium japonicum, Indian rorippa herb, spinach beet, fortune loosestrife herb, fringed pink, elaeagnus commutata root, sheathstipe greenbrier tuber and root, earthworm, logwood, Chinese elder, cynomorium songaricum, largeleaf curculigo rhizome, david anemone rhizome, orchidaceae pecteilis, fructus lycii, mimosa pudica, common bombax flower, luisia morsei, hemsleya macrosperma, uncinata spikemoss herb, herba osbeckiae opiparae, slender falsenettle herb, jasminum elongatum, purslane, rattlesnake plantain and ishige okamurae. The medicine has the beneficial effects of mainly clearing heat, removing toxicity and removing dampness with blood promotion and stasis removal, and is mainly used for treating benign prostatic hyperplasia due to damp-retained heat. The medicine is scientifically combined by traditional Chinese medicinal materials with different medicinal properties to achieve ideal treatment effects, is convenient to take and easy to manufacture, has the advantages of simple preparation process, low cost, safety and no toxic or side effect, can be used for directly acting on focuses, is short in healing time, and can prevent relapse after healing.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of medicine and preparation method for the treatment of stasis of blood humidifying pattern of fever prostatic hyperplasia.
Background technology
Prostatic hyperplasia (BPH) is the prostate compressing prostate-urethra or cause obstruction of vesicourethral orifice of hypertrophy, occurs frequent micturition, dysuria, and even the disease that cannot get rid of of urine, is the common disease of elderly men.BPH roughly belongs to the category of Chinese medicine " difficulty in urination ".The name of disease head of " difficulty in urination " sees "Nei Jing", and discusses its etiology and pathogenesis, sick position.Later age respectively sums up again on this basis for doctor, study, innovate, apply, and has formulated many effective methods.According to Epidemiological study display BPH40 year following sickness rate very low, within 50 years old, to account for after 40%, 80 years old sickness rate close to 90%, during by 90 years old, if carry out prostata tissue BPH to check almost 100% discovery BPH.
The cause of disease
About the study of incident mechanism of prostatic hyperplasia is a lot of, but the cause of disease still fails to illustrate so far.Current known prostatic hyperplasia must have the testis of function and the age increases by two conditions.Also the relation that smoking, obesity and excessive drinking, family history, ethnic group and geographical environment occur BPH is noticed in recent years.
Clinical manifestation
Prostatic hyperplasia early stage due to compensatory, atypical symptom, along with lower urinary tract obstruction increases the weight of, symptom is obvious gradually, and clinical symptoms comprises urine storage phase symptom, urinate phase symptom and post micturition symptoms.Because course advancement is slow, be difficult to determine the onset time.
1. urine storage phase symptom
(1) frequent micturition, nocturia increase frequent micturition is early symptom, be first that nocturia number of times increases, but each urine volume is few.After detrusor of bladder mistake is compensatory, chronic urinary retention occurs, and thus the available capacity of bladder reduces, and the interval between micturition time more shortens.If with vesical calculus or infection, then frequent micturition is further obvious, and with dysurea.
(2), when urgent micturition, urinary incontinence lower urinary tract obstruction, the patient of 50% ~ 80% has urgent micturition or urge incontinence.
2. to urinate phase symptom
Dysuria: along with body of gland increases, mechanical obstruction increases the weight of, increased dysurics, and the degree of lower urinary tract obstruction is not directly proportional to body of gland size.Because urethral resistance increases, controlled micturition is initial to be delayed, and urination time extends, and range is not far, and urine line is thin and unable.Urine bifurcated, has vesical tenesmus to feel.Increase the weight of further as blocked, patient must increase abdominal pressure to help to urinate.Breathing makes abdominal pressure increase and decrease, occur urine stream interrupt and dripping.
3. post micturition symptoms
Urine retention, residual urine increase: residual urine is that detrusor of bladder loses compensatory result.When residual urine volume is very large, bladder excessive expands and pressure is very high, and higher than urethral resistance, urine and stool is overflowed from urethra voluntarily, claims overflow incontinence.Some patients at ordinary times residual urine are few, but suffering from cold, drink, suppressing urine, drug administration or when having other reasons to cause sympathetic activation, suddenly acute urinary retention can occur.The symptom of Urinary retention can fashion time bad.Some patients can be acute urinary retention is onset symptoms.
Current doctor trained in Western medicine mainly takes symptomatic treatment to this, but medication effect is not satisfied.Excision prostatic hyperplasia is comparatively ideal treatment means.But the weak and most meeting of old health is with other system disease, being not suitable for operation or emotion repel operation.
Chinese medicine utilizes Traditional Chinese medical theory, on the basis of Overall View, by regulating qi-blood circulating, enhancing human body immunity power, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and Chinese traditional treatment prostatic hyperplasia has instant effect, relieve the pain rapid, thorough treatment, drug effect is gone directly focus, safe and effective, the course for the treatment of is shorter, and not easily produces that drug resistance, cost price are lower, convenient drug administration, patient is easy to accept, can cure rate be significantly improved, reduce complication, reduce relapse rate, significantly improve the quality of life etc. of patient.Chinese medical discrimination is divided into Four types: asthenia of renal qi type, sinking of QI due to deficiency of the spleen type, stasis blocking qi-deficiency type and stasis of blood humidifying pattern of fever.Wherein stasis of blood humidifying pattern of fever cardinal symptom is: frequent micturition, and short urination is fervid, urine drop and going out, and even urine retention is obstructed, pain in stem, little distention and fullness in the abdomen, urination disorder and short red causalgia, red tongue, yellow and greasy fur, slippery and rapid pulse.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of medicine and preparation method for the treatment of stasis of blood humidifying pattern of fever prostatic hyperplasia, and medicine of the present invention, based on clearing heat, detoxicating, dispelling dampness, is held concurrently with blood circulation promoting and blood stasis dispelling, cured mainly stasis of blood humidifying pattern of fever prostatic hyperplasia.Drug utilization Traditional Chinese medical theory of the present invention, formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, with low cost.The present invention is pharmaceutical preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, makes the abnormal smells from the patient of Chinese medicine preparation and light.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and focus of going directly, healing time is short, not easily recurs after healing.
In order to realize foregoing invention object, the invention provides a kind of medicine for the treatment of stasis of blood humidifying pattern of fever prostatic hyperplasia, comprise following raw medicinal material: Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae, Radix Betae, Herba Lysimachiae Fortunei, Herba Dianthi, Radix elaeagni glabrae, Rhizoma et radix smilacis santis, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii, Rhizoma Curculiginis Capitulatae, Rhizoma anemones davidii, Bai Diehua, Fructus Lycii, Herba Mimosae Pudicae, Flos Bombacis Malabarici, Radix Seu Herba Luisiae Morsei, Radix Hemsleyae Macrospermae, CUIYUNCAO, jar grass, Herba Boehmeriae Gracilis, Herba Oxalidis strictae, Herba Portulacae, Herba goodyearae repentis and Ishige okamurae Yendo.
In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 4-11 part, Herba pteridii latiusculi beanstalk 11-16 part, Spica Prunellae 15-24 part, Herba Cichorii 23-32 part, Herba lygodii 10-17 part, Herba Rorippae 10-19 part, Radix Betae 11-18 part, Herba Lysimachiae Fortunei 11-17 part, Herba Dianthi 17-24 part, Radix elaeagni glabrae 5-12 part, Rhizoma et radix smilacis santis 8-15 part, Pheretima 19-28 part, Lignum Sappan 6-13 part, Herba sambuci chinensis 7-13 part, Herba Cynomorii 15-27, Rhizoma Curculiginis Capitulatae 10-18 part, Rhizoma anemones davidii 11-16 part, white butterfly flower 12-19 part, Fructus Lycii 21-34 part, Herba Mimosae Pudicae 6-12 part, Flos Bombacis Malabarici 10-16 part, Radix Seu Herba Luisiae Morsei 5-11 part, Radix Hemsleyae Macrospermae 4-10 part, CUIYUNCAO 13-21 part, jar grass 16-22 part, Herba Boehmeriae Gracilis 16-23 part, Herba Oxalidis strictae 11-18 part, Herba Portulacae 25-34 part, Herba goodyearae repentis 15-24 part and Ishige okamurae Yendo 17-23 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 5-10 part, Herba pteridii latiusculi beanstalk 12-15 part, Spica Prunellae 16-22 part, Herba Cichorii 25-30 part, Herba lygodii 11-15 part, Herba Rorippae 12-17 part, Radix Betae 12-16 part, Herba Lysimachiae Fortunei 12-15 part, Herba Dianthi 18-23 part, Radix elaeagni glabrae 6-11 part, Rhizoma et radix smilacis santis 9-13 part, Pheretima 20-26 part, Lignum Sappan 7-12 part, Herba sambuci chinensis 8-12 part, Herba Cynomorii 17-25, Rhizoma Curculiginis Capitulatae 11-16 part, Rhizoma anemones davidii 12-14 part, white butterfly flower 13-18 part, Fructus Lycii 22-33 part, Herba Mimosae Pudicae 7-10 part, Flos Bombacis Malabarici 11-15 part, Radix Seu Herba Luisiae Morsei 6-10 part, Radix Hemsleyae Macrospermae 5-9 part, CUIYUNCAO 15-20 part, jar grass 17-21 part, Herba Boehmeriae Gracilis 18-20 part, Herba Oxalidis strictae 12-17 part, Herba Portulacae 27-32 part, Herba goodyearae repentis 15-22 part and Ishige okamurae Yendo 17-20 part.
In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 5 parts, Herba pteridii latiusculi beanstalk 13 parts, Spica Prunellae 22 parts, Herba Cichorii 30 parts, Herba lygodii 14 parts, Herba Rorippae 12 parts, Radix Betae 16 parts, Herba Lysimachiae Fortunei 15 parts, Herba Dianthi 18 parts, Radix elaeagni glabrae 9 parts, Rhizoma et radix smilacis santis 11 parts, Pheretima 20 parts, Lignum Sappan 12 parts, Herba sambuci chinensis 10 parts, Herba Cynomorii 25, Rhizoma Curculiginis Capitulatae 11 parts, Rhizoma anemones davidii 13 parts, white butterfly spends 18 parts, Fructus Lycii 22 parts, Herba Mimosae Pudicae 10 parts, Flos Bombacis Malabarici 12 parts, Radix Seu Herba Luisiae Morsei 6 parts, Radix Hemsleyae Macrospermae 9 parts, CUIYUNCAO 18 parts, jar grass 17 parts, Herba Boehmeriae Gracilis 19 parts, Herba Oxalidis strictae 12 parts, Herba Portulacae 30 parts, Herba goodyearae repentis 15 parts and Ishige okamurae Yendo 20 parts.
In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 7 parts, Herba pteridii latiusculi beanstalk 15 parts, Spica Prunellae 16 parts, Herba Cichorii 27 parts, Herba lygodii 11 parts, Herba Rorippae 17 parts, Radix Betae 14 parts, Herba Lysimachiae Fortunei 13 parts, Herba Dianthi 21 parts, Radix elaeagni glabrae 11 parts, Rhizoma et radix smilacis santis 9 parts, Pheretima 26 parts, Lignum Sappan 7 parts, Herba sambuci chinensis 12 parts, Herba Cynomorii 21 parts, Rhizoma Curculiginis Capitulatae 16 parts, Rhizoma anemones davidii 12 parts, white butterfly spends 15 parts, Fructus Lycii 33 parts, Herba Mimosae Pudicae 9 parts, Flos Bombacis Malabarici 15 parts, Radix Seu Herba Luisiae Morsei 10 parts, Radix Hemsleyae Macrospermae 5 parts, CUIYUNCAO 20 parts, jar grass 19 parts, Herba Boehmeriae Gracilis 20 parts, Herba Oxalidis strictae 17 parts, Herba Portulacae 27 parts, Herba goodyearae repentis 22 parts and Ishige okamurae Yendo 19 parts.
In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 10 parts, Herba pteridii latiusculi beanstalk 12 parts, Spica Prunellae 19 parts, Herba Cichorii 25 parts, Herba lygodii 15 parts, Herba Rorippae 16 parts, Radix Betae 12 parts, Herba Lysimachiae Fortunei 12 parts, Herba Dianthi 23 parts, Radix elaeagni glabrae 6 parts, Rhizoma et radix smilacis santis 13 parts, Pheretima 25 parts, Lignum Sappan 11 parts, Herba sambuci chinensis 8 parts, Herba Cynomorii 17 parts, Rhizoma Curculiginis Capitulatae 14 parts, Rhizoma anemones davidii 14 parts, white butterfly spends 13 parts, Fructus Lycii 28 parts, Herba Mimosae Pudicae 7 parts, Flos Bombacis Malabarici 11 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Hemsleyae Macrospermae 7 parts, CUIYUNCAO 15 parts, jar grass 21 parts, Herba Boehmeriae Gracilis 18 parts, Herba Oxalidis strictae 13 parts, Herba Portulacae 32 parts, Herba goodyearae repentis 21 parts and Ishige okamurae Yendo 17 parts.
In order to better realize goal of the invention, the invention provides a kind of preparation method for the treatment of the medicine of stasis of blood humidifying pattern of fever prostatic hyperplasia, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
In order to better realize goal of the invention, the invention provides a kind of preparation method for the treatment of the medicine of stasis of blood humidifying pattern of fever prostatic hyperplasia, when the dosage form of described medicine is fumigant, its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii with Herba Rorippae mixes in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, loads in non-woven fabrics medicated bag, often wraps 100 grams.
In order to better realize goal of the invention, the invention provides a kind of preparation method for the treatment of the medicine of stasis of blood humidifying pattern of fever prostatic hyperplasia, when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, distillation crystallization obtain powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extracts 1 time, and extract 1.5-2 hour, thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
The beneficial effect that technical scheme provided by the invention is brought is: medicine of the present invention, based on clearing heat, detoxicating, dispelling dampness, is held concurrently with blood circulation promoting and blood stasis dispelling, cured mainly stasis of blood humidifying pattern of fever prostatic hyperplasia; Adopt the Chinese crude drug of different properties to carry out scientific compatibility, can reach desirable therapeutic effect, processing technology is easy, convenient drug administration, and medicament is easy to manufacture, with low cost, and safely, have no side effect, focus of going directly, healing time is short, not easily recurs after healing.
Detailed description of the invention
The present invention is based on clearing heat, detoxicating, dispelling dampness, hold concurrently with blood circulation promoting and blood stasis dispelling, cure mainly stasis of blood humidifying pattern of fever prostatic hyperplasia, select following raw medicinal material: Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae, Radix Betae, Herba Lysimachiae Fortunei, Herba Dianthi, Radix elaeagni glabrae, Rhizoma et radix smilacis santis, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii, Rhizoma Curculiginis Capitulatae, Rhizoma anemones davidii, Bai Diehua, Fructus Lycii, Herba Mimosae Pudicae, Flos Bombacis Malabarici, Radix Seu Herba Luisiae Morsei, Radix Hemsleyae Macrospermae, CUIYUNCAO, jar grass, Herba Boehmeriae Gracilis, Herba Oxalidis strictae, Herba Portulacae, Herba goodyearae repentis and Ishige okamurae Yendo.
Wherein, Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae heat-clearing and toxic substances removing; Radix Betae, Herba Lysimachiae Fortunei, Herba Dianthi, Radix elaeagni glabrae, Rhizoma et radix smilacis santis, Pheretima, Lignum Sappan He Herba sambuci chinensis blood circulation promoting and blood stasis dispelling; Herba Cynomorii, Rhizoma Curculiginis Capitulatae, Rhizoma anemones davidii, Bai Diehua, Fructus Lycii the kidney invigorating; Herba Mimosae Pudicae, Flos Bombacis Malabarici, Radix Seu Herba Luisiae Morsei, Radix Hemsleyae Macrospermae, CUIYUNCAO, jar grass, Herba Boehmeriae Gracilis, Herba Oxalidis strictae and Herba Portulacae dampness removing; Herba goodyearae repentis and Ishige okamurae Yendo software eliminating stagnation.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herba Violae dissectae: for Violaceae plants herb or root, the rhizome of special decomposite leaf common violet.Bitter in the mouth; Cold in nature.GUIXIN; Gallbladder; Spleen; Liver Channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main furuncle swelling toxin; Measles pyretic toxicity; Pneumonia; Pleuritis; Stranguria with turbid discharge; Leucorrhea; Nephritis.
Herba pteridii latiusculi beanstalk: another name Botrypus virginianus(L.)Holub[Osmunda virginiana L,Botrychium virginianum(L.) Sw., YIDUOYUN.Fern Botrychiaceae Herba pteridii latiusculi beanstalk platymiscium Herba pteridii latiusculi beanstalk, with all herbal medicine.Bitter, puckery, cool.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For lung abscess, eye conjunctivitis; Traumatic injury is controlled in external, venom, lymphoid tuberculosis.
Spica Prunellae: bitter in the mouth, pungent, cold in nature, enters liver, gallbladder meridian, " herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity, Spica Prunellae all has inhibitory action to dysentery bacterium, escherichia coli, cholera bacilli etc.
Herba Cichorii: call blue chrysanthemum.For the aerial parts of feverfew Herba Cichorii.Bitter in the mouth; Property is matched.Heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main jaundice due to damp-heat; Oedema due to nephritis; Epigastric distending pain.
Herba lygodii: another name bamboo plantation Sui (《 Lv Cliff rock book on Chinese herbal medicine "), blurred net (" the SHENGCAO property of medicine is standby to be wanted "), chicken glue big (" interrogating book on Chinese herbal medicine "), Strepopelia orientalis nest (" vegetation is side just "), left seal character rattan, Herba Anoectochili roxburghii, the towel that scores a goal, Gold Pagoda (" classifying herbal ").For the herb of Lygodiaceae plant Spora Lygodii.Sweet; Cold.Return small intestinal; Bladder; Liver Channel.Heat-clearing and toxic substances removing; Relieving stranguria by diuresis; Promoting blood circulation to remove obstruction in the collateral.Main pyretic stranguria; Stranguria caused by urinary stone; Stranguria with blood; Dysuria; Edema; Nebulousurine; Leukorrhagia; Hepatitis; Have loose bowels; Dysentery; Cold, fever; Cough with asthma; Laryngopharynx swelling and pain; Aphtha; Conjunctival congestion and swelling pain; Mumps; Acute mastitis; Erysipelas; Herpes zoster; Burn due to hot liquid or fire; Skin pruritus; Traumatic injury wound is swollen; Rheumatic arthralgia; Traumatic hemorrhage.
Herba Rorippae: Shi word Hua Ke Herba Rorippae Shu Zhi Wu Herba Rorippae or Herba Rorippae, with all herbal medicine.Sweet, light, cool.Heat-clearing and toxic substances removing, antitussive, diuresis.For cold, fever, laryngopharynx swelling and pain, cough due to lung-heat, chronic tracheitis, acute rheumatic arthritis, hepatitis, dysuria; Dermatitis rhus is controlled in external, venom, furuncle carbuncle.
Radix Betae: Bie Ming Chard dish (" not Lu "), Radix Betae (" Japan hanako materia medica "), leaf beet (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), stone dish (" book on Chinese herbal medicine asks former "), Wood-scoop dish, pig Bovine dish (" Guangzhou flora "), light dish (" China's Vegetable cultivation ").For stem, the leaf of multitude Zhong Zhi Wu Radix Betae
.sweet; Bitter; Cold in nature.Return lung; Kidney; Large intestine channel.Heat-clearing and toxic substances removing; Clots absorbing stops blooding.Row calentura time main; Hemorrhoid; Measles is sent out not smooth thoroughly; Spit blood; Pyretic toxicity dysentery; Amenorrhea; Stranguria with turbid discharge; Carbuncle; Traumatic injury; Snakeworm hinders.
Herba Lysimachiae Fortunei: another name Herba polygoni lapathifolii, Misgurni anguillicaudati dish (" Guangzhou flora "), Arisaema balansae Engl. grass (" Fujian traditional herbal medicine "), red aerial root, red seven grass, Herba Lysimachiae Fortunei, hundred decoct grass, frog secondary rainbow grass (" Guangxi Chinese veterinarian's medicine is planted "), are herb or the whole herb with root of Ofthe Primulaceae Herba Lysimachiae Fortunei.Bitterness, flat.Invigorate blood circulation, dissipating blood stasis, diuretic, removing dampness.Control traumatic injury, articular rheumatic pain, women's amenorrhea, acute mastitis, scrofula, conjunctival congestion and swelling pain, edema, yellow cellulitis, malaria, dysentery.
Herba Dianthi: another name Dianthus chinensis flower, ten sample scape flowers, Luoyang flower.This product is the dry aerial parts of Caryophyllaceae carnation Herba Dianthi or Dianthus chinensis.Hardship, cold.GUIXIN, small intestine meridian.Inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, menstruation apolipsis.
Radix elaeagni glabrae: be root or the root bark of Elaeangnaceae plant Fructus elaeagni glabrae
.acrid in the mouth; Micro-puckery; Cool in nature.Return liver; Spleen; Large intestine channel.Clearing away heat-damp and promoting diuresis; Treating stranguria hemostasis; Eliminating stasis to stop pain.Main dysentery; Diarrhoea; Icterohepatitis; Pyretic stranguria; Stranguria caused by urinary stone; Stomachache; Spit blood; Hemorrhoidal bleeding; Metrorrhagia; Rheumatic arthralgia; Treating swelling and pain by traumatic injury.
Rhizoma et radix smilacis santis: be tuber and the root of liliaceous plant sheath handle Rhizoma Smilacis Chinensis.Bitter in the mouth, property is put down, expelling wind and removing dampness, activating blood cirulation to regulate QI flow, pain relieving.Dispelling the wind and dampness pathogens pain, traumatic injury, traumatic hemorrhage, fishbone bone stuck in the throat.
Pheretima: salty, cold.Return liver, spleen, urinary bladder channel.Effect: heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the disease such as erysipelas, dermatitis rhus.
Lignum Sappan: sweet, salty, pungent, cool; The heart, liver, stomach, spleen channel.Blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.As married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus." Japan hanako materia medica ": " control married woman's vim and vigour cardiac and abdominal pain, the moon waits uncomfortable and postpartum debility.Evacuation of pus pain relieving, subduing inflammation flutters damage blood stasis, woman's aphonia, and blood is kept silent, and dysentery with red and white feces is rear point shoot also." blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.
Herba sambuci chinensis: be herb or the root of caprifoliaceae plant Herba sambuci chinensis
.sweet acid, temperature.Enter liver channel of foot-Jueyin.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis.Dispelling the wind and dampness pathogens pain, oedema due to nephritis, beriberi edema, dysentery, jaundice, chronic tracheitis, rubella pruritus, erysipelas, skin ulcer swells, traumatic injury, fracture.
Herba Cynomorii: another name rust iron hammer, ball top, lock swallow.This product is the dry meat stem of Cynomoriaceae plant Herba Cynomorii.Sweet in the mouth; Warm in nature.Return kidney; Liver; Large intestine channel.Kidney invigorating and YANG supporting; The relieving constipation of benefit intestinal.Main impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Flaccidity and weakness of the lower limbs; Empty people's constipation.
Rhizoma Curculiginis Capitulatae: be the rhizome of bloodwort great Ye Rhizoma Curculiginis.Pungent; Micro-hardship; Temperature.Return kidney; Lung; Liver Channel.Kidney invigorating and YANG supporting; Expelling wind and removing dampness; Promoting blood flow to regulate menstruation.Main cough with asthma of suffering from a deficiency of the kidney; Impotence and seminal emission; Nebulousurine leukorrhagia; Soreness of the waist and knees; Rheumatic arthralgia; Cold womb is infertile; Menoxenia; Metrorrhagia; Uterine prolapse; Traumatic injury.
Rhizoma anemones davidii: another name Carnis Rapanae thomasianae seven, furuncle medicine, copper lamp-stand.Ranunculaceae thimbleweed southwest Anemone cathayensis Kitag., is used as medicine with root stock.Micro-hardship, temperature.Blood circulation promoting and blood stasis dispelling, kidney invigorating and YANG supporting.For traumatic injury, lumbar muscle strain, sexual impotence.
White butterfly flower: be the tuber that orchid tap is blue.Sweet in the mouth; Slightly warm in nature.Kidney invigorating and YANG supporting; Soothing the liver cold expelling.Main lumbago due to renal deficiency; Sexual impotence; Seminal emission; Colic of cold type.
Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Herba Mimosae Pudicae: sweet, puckery, cool.Slightly poisonous.Clearing away heat and promoting diuresis, preventing phlegm from forming and stopping coughing, ataralgesia.For flu, infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, urinary system calculus, malaria, neurasthenia; Treating swelling and pain by traumatic injury is controlled in external, sore swollen toxin.
Flos Bombacis Malabarici: be the flower of Bombacaceae plant kapok
.sweet; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.Master has loose bowels; Dysentery; Hemoptysis; Spit blood; Metrorrhagia; Incised wound is hemorrhage; Sore; Eczema.
Radix Seu Herba Luisiae Morsei: Cornu Bovis seu Bubali blue, parasitic orchid, Herba bidentis parviflorae, hang bamboo.For the orchid family Fork epidendrum Radix Seu Herba Luisiae Morsei, with all herbal medicine.Loose wind eliminates the phlegm, removing toxic substances and promoting subsidence of swelling.For rheumatic arthritis, the breast side of body is injured, carbuncle, laryngitis etc.Bitter; Pungent; Cool in nature; Mild toxicity.Return lung; The heart; Liver; Kidney channel.Heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main malaria; Carbuncle; Laryngopharynx swelling and pain; Rheumatic arthralgia; Edema; Nebulousurine; Leukorrhagia; Traumatic injury; Medicine or alimentary toxicosis.
Radix Hemsleyae Macrospermae: call golden basin, Gold Testudinis basin, gold silver basin, native Fructus Aristolochiae, little Jin melon, Herba dichocarpi fargesii, gold hang young cucumber, golden arrowhead, Ipomoea hungaiensis Lingelsh. Et Borza. internal diabetes, bitter golden basin, golden waist lotus gold basin, Herba Lactucae formosanae plate, Pan Lian.For the tuber of cucurbitaceous plant China Radix Hemsleyae Macrospermae, Hemsleya amabilis Diels and large seed Radix Hemsleyae Macrospermae.Bitter in the mouth; Cold in nature; Mild toxicity.GUIXIN; Stomach; Large intestine channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema; Analgesic hemostatic.Main laryngopharynx swelling and pain; Toothache; Conjunctival congestion and swelling pain; Stomachache; Bacillary dysentery; Intestinal is scorching; Hepatitis; Urinary tract infection; Prostatitis; Hemorrhoid; Cervicitis; Carbuncle furuncle; Traumatic hemorrhage.
CUIYUNCAO: call sword cypress, blue Sabina procumbens, Herba Asplenii Incisi, stretch foot grass, green floss is careless, bark rot Serpentis.Selaginaceae Rock lily plant CUIYUNCAO, with all herbal medicine.Sweet, light, cool.Clearing away heat-damp and promoting diuresis, hemostasis, cough-relieving.For acute icteric infectious hepatitis, cholecystitis, enteritis, dysentery, oedema due to nephritis, urinary system infection, rheumatic arthritis, hemoptysis of pulmonary tuberculosis; Furuncle and phyma is controlled in external, burn and scald, traumatic hemorrhage, traumatic injury.
Jar grass: call look up to heaven tank, the red cylinder of high foot, line chicken foot, great Jin clock, hectolitre pomegranate, Thalictrum omeiense W. T. Wang et S. H. Wang, broad-leaved Radix Osbeckiae Crinitae.For the branch and leaf of Melastomateae plants Radix Osbeckiae Crinitae.Bitter in the mouth; Sweet; Property is put down.Clearing away heat-damp and promoting diuresis; Blood-arresting catamenia-regulating.Main damp-heat dysentery; Drench pain; Chronic cough; Chronic cough; Spitting of blood; Menoxenia; Leucorrhea.
Herba Boehmeriae Gracilis: be the herb of the thin wild flax of contrayerva
.pungent; Micro-hardship; Property is put down.Dispelling wind for relieving itching; Removing toxic substances profit temperature.Main skin pruritus; Eczema of lower limb rash." Shaanxi Chinese herbal medicine ": heat-clearing and toxic substances removing, except wind is antipruritic, dampness removing.Control skin to itch, noxious dampness.
Herba Oxalidis strictae: another name spends tea, false jasmine in vain, Gaster Sus domestica is strangled, Sinomenium acutum is sub spends.Oleaceae Flos Jasmini Sambac platymiscium Herba Oxalidis strictae, is used as medicine with stem, leaf.Micro-hardship, cool.Heat-clearing and toxic substances removing, dampness removing disappears stagnant.For acute gastroenteritis, dysentery, dyspepsia, acute conjunctivitis, acute tonsillitis.
Herba Portulacae: acid, cold.Return large intestine, liver, spleen channel.Heat-clearing and toxic substances removing, loose blood detumescence.Control hematodiarrhoea pus and blood, pyretic stranguria, stranguria with blood, leukorrhagia, carbuncle malignant boil, erysipelas, trace scrofula.For damp and hot caused diarrhoea, dysentery, often join Rhizoma Coptidis, the Radix Aucklandiae.Take orally or smash juice external application, controlling carbuncle.Also for having blood in stool, metrorrhagia, have anastalsis.
Herba goodyearae repentis: another name lobule green grass or young crops, little green grass or young crops, Folium Cannabis green grass or young crops, Herba goodyearae repentis, Agkistrodon medicine.The orchid family Herba goodyearae repentis platymiscium Herba goodyearae repentis, with all herbal medicine.Xia Qiu excavates, using fresh herb or clean dry.Light, cold.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling, pain relieving.For pulmonary tuberculosis cough, bronchitis; Venom is controlled in external, carbuncle furuncle infections.
Ishige okamurae Yendo: another name Herba cynodontis, Herba violae patrinii, ferrum dish, shaker bell.Medical material Ji Yuan: be the frond of Ishigeaceae plant Ishige okamurae Yendo and lobate Ishige okamurae Yendo.Salty; Cold.Return Liver Channel.Hard masses softening and resolving; Removing toxic substances; Drive ascarid.Main lymphonodi cervicales swells; Goiter; Laryngitis; Ascariasis.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 capsule of the present invention
Get Herba Violae dissectae 5g, Herba pteridii latiusculi beanstalk 13g, Spica Prunellae 22g, Herba Cichorii 30g, Herba lygodii 14g, Herba Rorippae 12g, Radix Betae 16g, Herba Lysimachiae Fortunei 15g, Herba Dianthi 18g, Radix elaeagni glabrae 9g, Rhizoma et radix smilacis santis 11g, Pheretima 20g, Lignum Sappan 12g, Herba sambuci chinensis 10g, Herba Cynomorii 25g, Rhizoma Curculiginis Capitulatae 11g, Rhizoma anemones davidii 13g, white butterfly flower 18g, Fructus Lycii 22g, Herba Mimosae Pudicae 10g, Flos Bombacis Malabarici 12g, Radix Seu Herba Luisiae Morsei 6g, Radix Hemsleyae Macrospermae 9g, CUIYUNCAO 18g, jar grass 17g, Herba Boehmeriae Gracilis 19g, Herba Oxalidis strictae 12g, Herba Portulacae 30g, Herba goodyearae repentis 15g and Ishige okamurae Yendo 20g.
Its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 5, stirs 90 minutes, temperature 50 C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.17;
Second step, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 4 times, each 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times of water gagings, boil 7 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 6 weight portion carboxymethyl starch sodium, 40 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 4 weight portion magnesium stearate, then load in gelatine capsule.
Embodiment 2 fumigant of the present invention
Get Herba Violae dissectae 7g, Herba pteridii latiusculi beanstalk 15g, Spica Prunellae 16g, Herba Cichorii 27g, Herba lygodii 11g, Herba Rorippae 17g, Radix Betae 14g, Herba Lysimachiae Fortunei 13g, Herba Dianthi 21g, Radix elaeagni glabrae 11g, Rhizoma et radix smilacis santis 9g, Pheretima 26g, Lignum Sappan 7g, Herba sambuci chinensis 12g, Herba Cynomorii 21g, Rhizoma Curculiginis Capitulatae 16g, Rhizoma anemones davidii 12g, white butterfly flower 15g, Fructus Lycii 33g, Herba Mimosae Pudicae 9g, Flos Bombacis Malabarici 15g, Radix Seu Herba Luisiae Morsei 10g, Radix Hemsleyae Macrospermae 5g, CUIYUNCAO 20g, jar grass 19g, Herba Boehmeriae Gracilis 20g, Herba Oxalidis strictae 17g, Herba Portulacae 27g, Herba goodyearae repentis 22g and Ishige okamurae Yendo 19g.
Its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii with Herba Rorippae mixes in described ratio, be the dissolve with ethanol of 95% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add the ethanol of the determining alcohol 95% of 4 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.20, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1 times relative to the mixture quality obtained, again heat decoction 2 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, loads in non-woven fabrics medicated bag, often wraps 100 grams.
Embodiment 3 honey refining of the present invention pill
Get Herba Violae dissectae 10g, Herba pteridii latiusculi beanstalk 12g, Spica Prunellae 19g, Herba Cichorii 25g, Herba lygodii 15g, Herba Rorippae 16g, Radix Betae 12g, Herba Lysimachiae Fortunei 12g, Herba Dianthi 23g, Radix elaeagni glabrae 6g, Rhizoma et radix smilacis santis 13g, Pheretima 25g, Lignum Sappan 11g, Herba sambuci chinensis 8g, Herba Cynomorii 17g, Rhizoma Curculiginis Capitulatae 14g, Rhizoma anemones davidii 14g, white butterfly flower 13g, Fructus Lycii 28g, Herba Mimosae Pudicae 7g, Flos Bombacis Malabarici 11g, Radix Seu Herba Luisiae Morsei 9g, Radix Hemsleyae Macrospermae 7g, CUIYUNCAO 15g, jar grass 21g, Herba Boehmeriae Gracilis 18g, Herba Oxalidis strictae 13g, Herba Portulacae 32g, Herba goodyearae repentis 21g and Ishige okamurae Yendo 17g.
Its preparation method comprises the following steps:
Step 1: first by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, distillation crystallization obtain powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 90% soak with ethanol 1-2 hour of mixture 4 times amount, heating extraction 2 times, each 1 hour, merge extractive liquid, 150 orders filter, be the ultrafiltration post ultrafiltration of 98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 5 times amount water soaking 2 hours, extracts 1 time, and extract 2 hours, thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
Toxicity test:
Long term toxicity test:
The capsule of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the capsule of the embodiment of the present invention 1 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
The honey refining pill of the embodiment of the present invention 3 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the honey refining pill of the embodiment of the present invention 3 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Acute skin irritation test:
These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, after fumigant prepared by embodiments of the invention 2 being added 5 quality deionized water doubly, directly to be coated on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
Clinical data:
Case selection: the stasis of blood humidifying pattern of fever Patients with Prostatic Hyperplasia for the treatment of in my institute during being selected from February ,-2014 in January, 2011 is totally 188 examples, age 48-78 year, 57 years old mean age.Be divided into four groups at random, four groups in age, the course of disease all without significant difference, there is comparability.
Capsule treatment group: 47 people.
Fumigant treatment group: 47 people.
Honey refining pill treatment group: 47 people.
Western medicine group: 47 people.
Diagnostic criteria:
With reference to " Chinese medicine disease Standardization of diagnosis and curative effect "
1, start frequent micturition, especially nocturia increased frequency, gradually has dysuria, remaining drown endless, urine retention or urinary incontinence can be had time serious.
2, primary disease is more common in elderly men.
3, rectal touch: smart room is loose, smooth surface and without tuberosity, clear-cut margin, medium hardness and full of elasticity, Rolandic fissure shoals or disappears.
4, B is super checks: prostate size measurement compared with normal increases, and bladder remains urine and is greater than 60 milliliters.
Stasis of blood humidifying pattern of fever prostatic hyperplasia: frequent micturition, short urination is fervid, urine drop and going out, and even urine retention is obstructed, pain in stem, little distention and fullness in the abdomen.Red tongue, yellow and greasy fur, slippery and rapid pulse.
Criterion of therapeutical effect:
With reference to the industry standard " Chinese medical disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine promulgates, for hyperplasia of prostate efficacy evaluation:
Cure: unobstructed micturition, prostatic examination is obviously reduced, without residual urine.
Take a turn for the better: symptom of urinating takes a turn for the better, residual urine reduces.
Do not heal: symptom and every inspection are all without improvement.
Therapeutic Method:
Capsule treatment group: take capsule prepared by the embodiment of the present invention 1, every day 2 times, each 3 10 days is a course for the treatment of.
Fumigant treatment group: use fumigant prepared by the embodiment of the present invention 3, every day 2 times, each 1 bag 10 days is a course for the treatment of.By the medicated bag of fumigant, put into fumigating bed heater and build heater upper cover; Fumigating bed temperature is set in 45 degree, and when in stifling cabin, temperature reaches 45 degree, patient enters in cabin stifling, one day twice, one time 30 minutes.
Honey refining pill treatment group: take honey refining pill prepared by the embodiment of the present invention 3, every day 3 times, each 3 10 days is a course for the treatment of.
Western medicine group: oral simple western medicine finasteride 5mg, every day 1 time, tamsulosin hydrochloride sustained-release capsule 0.2 mg, every day 1 time 10 days is a course for the treatment of.
Therapeutic outcome:
See table 1, as can be seen from Table 1, adopt Drug therapy stasis of blood humidifying pattern of fever prostatic hyperplasia of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement.
After table 1 Four composition does not treat 2 courses for the treatment of, Clinical efficacy comparison is routine
| Group | Number of cases | Recovery from illness | Take a turn for the better | Invalid | Total effective rate |
| Capsule treatment group | 47 | 28 | 15 | 4 | 91.5% |
| Fumigant treatment group | 47 | 26 | 19 | 2 | 95.7% |
| Honey refining pill treatment group | 47 | 30 | 14 | 3 | 93.6% |
| Western medicine group | 47 | 23 | 17 | 7 | 85.1% |
According to above-mentioned clinical statistics, pharmaceutical preparation provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.
To the follow-up of patients 1 year of above-mentioned four groups of recoveries from illness, capsule treatment group, fumigant treatment group and honey refining pill treatment group are all without recurring.
23 examples of western medicine group recovery from illness, recurrence 6 example, relapse rate 26.1%.
Model case:
Poplar, man, 66 years old, in August, 2012 went to a doctor.Its main suit: frequent micturition, short urination is fervid, urine drop and going out, pain in stem, little distention and fullness in the abdomen, and to check etc. diagnosis in hospital by rectal touch, B are super, be diagnosed as prostatic hyperplasia subsequently, red tongue, yellow and greasy fur, slippery and rapid pulse, dialectical is stasis of blood humidifying pattern of fever.Use the fumigant of the embodiment of the present invention 2, by the medicated bag of fumigant, put into fumigating bed heater and build heater upper cover; Fumigating bed temperature is set in 45 degree, and when in stifling cabin, temperature reaches 45 degree, patient enters in cabin stifling, one day twice, one time one bag, once stifling 30 minutes.Use frequent micturition after 3 days to improve, use urine volume after 8 days progressively to recover normalization, use after 13 days, unobstructed micturition, prostatic examination is obviously reduced, and without residual urine, recovery from illness, advises it to continue use 7 days, consolidate curative effect.1 year afterwards return visit do not recur.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. treat the medicine of stasis of blood humidifying pattern of fever prostatic hyperplasia for one kind, it is characterized in that, comprise following raw medicinal material: Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae, Radix Betae, Herba Lysimachiae Fortunei, Herba Dianthi, Radix elaeagni glabrae, Rhizoma et radix smilacis santis, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii, Rhizoma Curculiginis Capitulatae, Rhizoma anemones davidii, Bai Diehua, Fructus Lycii, Herba Mimosae Pudicae, Flos Bombacis Malabarici, Radix Seu Herba Luisiae Morsei, Radix Hemsleyae Macrospermae, CUIYUNCAO, jar grass, Herba Boehmeriae Gracilis, Herba Oxalidis strictae, Herba Portulacae, Herba goodyearae repentis and Ishige okamurae Yendo.
2. medicine according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 4-11 part, Herba pteridii latiusculi beanstalk 11-16 part, Spica Prunellae 15-24 part, Herba Cichorii 23-32 part, Herba lygodii 10-17 part, Herba Rorippae 10-19 part, Radix Betae 11-18 part, Herba Lysimachiae Fortunei 11-17 part, Herba Dianthi 17-24 part, Radix elaeagni glabrae 5-12 part, Rhizoma et radix smilacis santis 8-15 part, Pheretima 19-28 part, Lignum Sappan 6-13 part, Herba sambuci chinensis 7-13 part, Herba Cynomorii 15-27 part, Rhizoma Curculiginis Capitulatae 10-18 part, Rhizoma anemones davidii 11-16 part, white butterfly flower 12-19 part, Fructus Lycii 21-34 part, Herba Mimosae Pudicae 6-12 part, Flos Bombacis Malabarici 10-16 part, Radix Seu Herba Luisiae Morsei 5-11 part, Radix Hemsleyae Macrospermae 4-10 part, CUIYUNCAO 13-21 part, jar grass 16-22 part, Herba Boehmeriae Gracilis 16-23 part, Herba Oxalidis strictae 11-18 part, Herba Portulacae 25-34 part, Herba goodyearae repentis 15-24 part and Ishige okamurae Yendo 17-23 part.
3. medicine according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 5-10 part, Herba pteridii latiusculi beanstalk 12-15 part, Spica Prunellae 16-22 part, Herba Cichorii 25-30 part, Herba lygodii 11-15 part, Herba Rorippae 12-17 part, Radix Betae 12-16 part, Herba Lysimachiae Fortunei 12-15 part, Herba Dianthi 18-23 part, Radix elaeagni glabrae 6-11 part, Rhizoma et radix smilacis santis 9-13 part, Pheretima 20-26 part, Lignum Sappan 7-12 part, Herba sambuci chinensis 8-12 part, Herba Cynomorii 17-25 part, Rhizoma Curculiginis Capitulatae 11-16 part, Rhizoma anemones davidii 12-14 part, white butterfly flower 13-18 part, Fructus Lycii 22-33 part, Herba Mimosae Pudicae 7-10 part, Flos Bombacis Malabarici 11-15 part, Radix Seu Herba Luisiae Morsei 6-10 part, Radix Hemsleyae Macrospermae 5-9 part, CUIYUNCAO 15-20 part, jar grass 17-21 part, Herba Boehmeriae Gracilis 18-20 part, Herba Oxalidis strictae 12-17 part, Herba Portulacae 27-32 part, Herba goodyearae repentis 15-22 part and Ishige okamurae Yendo 17-20 part.
4. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 5 parts, Herba pteridii latiusculi beanstalk 13 parts, Spica Prunellae 22 parts, Herba Cichorii 30 parts, Herba lygodii 14 parts, Herba Rorippae 12 parts, Radix Betae 16 parts, Herba Lysimachiae Fortunei 15 parts, Herba Dianthi 18 parts, Radix elaeagni glabrae 9 parts, Rhizoma et radix smilacis santis 11 parts, Pheretima 20 parts, Lignum Sappan 12 parts, Herba sambuci chinensis 10 parts, Herba Cynomorii 25 parts, Rhizoma Curculiginis Capitulatae 11 parts, Rhizoma anemones davidii 13 parts, white butterfly spends 18 parts, Fructus Lycii 22 parts, Herba Mimosae Pudicae 10 parts, Flos Bombacis Malabarici 12 parts, Radix Seu Herba Luisiae Morsei 6 parts, Radix Hemsleyae Macrospermae 9 parts, CUIYUNCAO 18 parts, jar grass 17 parts, Herba Boehmeriae Gracilis 19 parts, Herba Oxalidis strictae 12 parts, Herba Portulacae 30 parts, Herba goodyearae repentis 15 parts and Ishige okamurae Yendo 20 parts.
5. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 7 parts, Herba pteridii latiusculi beanstalk 15 parts, Spica Prunellae 16 parts, Herba Cichorii 27 parts, Herba lygodii 11 parts, Herba Rorippae 17 parts, Radix Betae 14 parts, Herba Lysimachiae Fortunei 13 parts, Herba Dianthi 21 parts, Radix elaeagni glabrae 11 parts, Rhizoma et radix smilacis santis 9 parts, Pheretima 26 parts, Lignum Sappan 7 parts, Herba sambuci chinensis 12 parts, Herba Cynomorii 21 parts, Rhizoma Curculiginis Capitulatae 16 parts, Rhizoma anemones davidii 12 parts, white butterfly spends 15 parts, Fructus Lycii 33 parts, Herba Mimosae Pudicae 9 parts, Flos Bombacis Malabarici 15 parts, Radix Seu Herba Luisiae Morsei 10 parts, Radix Hemsleyae Macrospermae 5 parts, CUIYUNCAO 20 parts, jar grass 19 parts, Herba Boehmeriae Gracilis 20 parts, Herba Oxalidis strictae 17 parts, Herba Portulacae 27 parts, Herba goodyearae repentis 22 parts and Ishige okamurae Yendo 19 parts.
6. according to the arbitrary described medicine of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae dissectae 10 parts, Herba pteridii latiusculi beanstalk 12 parts, Spica Prunellae 19 parts, Herba Cichorii 25 parts, Herba lygodii 15 parts, Herba Rorippae 16 parts, Radix Betae 12 parts, Herba Lysimachiae Fortunei 12 parts, Herba Dianthi 23 parts, Radix elaeagni glabrae 6 parts, Rhizoma et radix smilacis santis 13 parts, Pheretima 25 parts, Lignum Sappan 11 parts, Herba sambuci chinensis 8 parts, Herba Cynomorii 17 parts, Rhizoma Curculiginis Capitulatae 14 parts, Rhizoma anemones davidii 14 parts, white butterfly spends 13 parts, Fructus Lycii 28 parts, Herba Mimosae Pudicae 7 parts, Flos Bombacis Malabarici 11 parts, Radix Seu Herba Luisiae Morsei 9 parts, Radix Hemsleyae Macrospermae 7 parts, CUIYUNCAO 15 parts, jar grass 21 parts, Herba Boehmeriae Gracilis 18 parts, Herba Oxalidis strictae 13 parts, Herba Portulacae 32 parts, Herba goodyearae repentis 21 parts and Ishige okamurae Yendo 17 parts.
7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;
Second step, Pheretima, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;
4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is fumigant, its preparation method comprises the following steps:
The first step, by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii with Herba Rorippae mixes in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Lignum Sappan, Herba sambuci chinensis, Herba Cynomorii and Rhizoma Curculiginis Capitulatae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, loads in non-woven fabrics medicated bag, often wraps 100 grams.
9. according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first by Herba Violae dissectae, Herba pteridii latiusculi beanstalk, Spica Prunellae, Herba Cichorii, Herba lygodii, Herba Rorippae with Radix Betae mixes in described ratio, distillation crystallization obtain powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;
Step 3: step 2 Chinese medicine slag is added 4-6 times amount water soaking 1-2.5 hour, extracts 1 time, and extract 1.5-2 hour, thickening filtration is extractum shape, is component 2;
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105396078A (en) * | 2016-01-13 | 2016-03-16 | 济南思拓新源医药科技有限公司 | Traditional Chinese medicine for treating spleen deficiency and qi collapse type benign prostatic hyperplasia and preparation method thereof |
| EP4218782A4 (en) * | 2020-09-24 | 2024-04-10 | Jeonnam Bioindustry Foundation | Composition for prevention and treatment of benign prostatic hyperplasia, comprising fruit extracts of elaeagnus multriflora thunb. as active ingredient |
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| CN1823980A (en) * | 2005-12-29 | 2006-08-30 | 天津市曹开镛中医男科研究所 | Chinese medicinal preparation for treating chronic prostatitis and its manufacturing method |
| CN102716249A (en) * | 2011-03-29 | 2012-10-10 | 北京凯晋科技有限公司 | Medicinal composition for treating hyperplasia of prostate and preparation method thereof |
| CN104435913A (en) * | 2014-11-15 | 2015-03-25 | 张鹏 | Traditional Chinese medicine composition for treating prostatitis |
| CN104758754A (en) * | 2015-04-29 | 2015-07-08 | 许艳 | Medicine for treating kidney qi deficiency benign prostate hyperplasia and preparation method thereof |
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2015
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1823980A (en) * | 2005-12-29 | 2006-08-30 | 天津市曹开镛中医男科研究所 | Chinese medicinal preparation for treating chronic prostatitis and its manufacturing method |
| CN102716249A (en) * | 2011-03-29 | 2012-10-10 | 北京凯晋科技有限公司 | Medicinal composition for treating hyperplasia of prostate and preparation method thereof |
| CN104435913A (en) * | 2014-11-15 | 2015-03-25 | 张鹏 | Traditional Chinese medicine composition for treating prostatitis |
| CN104758754A (en) * | 2015-04-29 | 2015-07-08 | 许艳 | Medicine for treating kidney qi deficiency benign prostate hyperplasia and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105396078A (en) * | 2016-01-13 | 2016-03-16 | 济南思拓新源医药科技有限公司 | Traditional Chinese medicine for treating spleen deficiency and qi collapse type benign prostatic hyperplasia and preparation method thereof |
| EP4218782A4 (en) * | 2020-09-24 | 2024-04-10 | Jeonnam Bioindustry Foundation | Composition for prevention and treatment of benign prostatic hyperplasia, comprising fruit extracts of elaeagnus multriflora thunb. as active ingredient |
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