CN106266109A - A kind of Chinese medicine composition treating urinary system calculus and preparation method thereof - Google Patents
A kind of Chinese medicine composition treating urinary system calculus and preparation method thereof Download PDFInfo
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- CN106266109A CN106266109A CN201610825333.7A CN201610825333A CN106266109A CN 106266109 A CN106266109 A CN 106266109A CN 201610825333 A CN201610825333 A CN 201610825333A CN 106266109 A CN106266109 A CN 106266109A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention provides a kind of Chinese medicine composition treating urinary system calculus, be made up of the Chinese medicine of following weight: Herba Desmodii Styracifolii 10 30 parts, Endothelium Corneum Gigeriae Galli 10 30 parts, 10 30 parts of Spora Lygodii rattan, Folium Pyrrosiae 15 40 parts, Spora Lygodii 5 20 parts, Oletum Trogopterori 5 20 parts, Fructus Aurantii 5 15 parts, Pericarpium Citri Reticulatae 5 15 parts, Pulvis Talci 5 20 parts and 3 10 parts of Radix Glycyrrhizae.The Chinese medicine composition of the present invention all has a therapeutic effect to the urinary system calculus including including renal calculus, ureteral calculus, vesical calculus and calculus of urethra etc., and evident in efficacy, toxic and side effects is little, preparation method raw material is easy to get, step is simple, reproducible.
Description
Technical field
The invention belongs to field of traditional Chinese, in particular to a kind of Chinese medicine composition treating urinary system calculus and
Its preparation method.
Background technology
Calculus is in the catheter lumen in human body or animal body or chamber sexual organ (such as kidney, ureter, gallbladder or bladder etc.)
Chamber in formed solid mass.It is mainly seen in gallbladder and bladder, renal pelvis, it is possible to see pancreas conduit, salivary ducts etc.
In chamber.Calculus is made up of inorganic salt or Organic substance.Calculus typically has a core, by the epithelial cell come off, bacterial aggregate, posts
Infested ovum or polypide, excrement block or foreign body composition, inorganic salt or Organic substance deposit on core the most layer by layer.Due to afflicted organ not
All differ with, composition contained by lithogenous mechanism, shape, quality, impact etc. on body.Generally speaking, calculus can
Cause tube chamber to block, affect the discharge of afflicted organ's liquid, produce the symptoms such as pain, hemorrhage or secondary infection.
Urinary system calculus is one of modal urological diseases, has the advantages that sickness rate is high, the cause of disease is complicated.Root
Renal calculus, ureteral calculus, vesical calculus and calculus of urethra etc. can be divided into according to position, calculus place.Urinary system calculus at kidney and
Intravesical is formed.Upper urinary stone has significance difference with the Forming Mechanism of calculus of lower urinary tract, the cause of disease, calculus composition and epidemiology
Different.Upper urinary stone great majority are calcium oxalate stone.In vesical calculus, magnesium ammonium phosphate calculus is common compared with upper urinary tract.Ultrasonic rubble
Art, ureter endoscopic stone extraction technique, the percutaneous nephrolithotomy etc. achieve good development in recent years in terms of calculi therapy, effect
Significantly.Particularly laser lithotripsy becomes and applies most renal calculus treatment technologies in recent years.But the recurrence rate of calculus and controlling again
Rate is higher than traditional operation, and there is traumatic and complication.
Urinary system calculus often shows as dysurea, urine color muddiness or color, lumbago, accompanies frequent micturition, urgent micturition, yellow, greasy and thin fur, arteries and veins
Lubrication number, may result in time serious and blocks and renal failure.Renal calculus, ureteral calculus, vesical calculus and calculus of urethra etc. belong to
" stranguria caused by urinary stone ", " sand Stranguria ", " stranguria with blood " and " stomachache " of " stranguria ", the scope of " waist is swollen " in motherland's medical science.Sending out of urinary system calculus
Raw reason successive dynasties books are recorded quite detailed, " General Treatise on the Cause and Symptoms of Diseases " cloud: " Zhu Linzhe, by and bladder heat thus also." " Huatuo's Zhongzang classic " cloud: " empty
Feeling frustrated, pathogenic heat crescendo, knot is poly-forms sandstone, and and for example decocting in water salt, fire too water is few, salt gradually Cheng Shi etc." its disease is many accumulates for a long time because of damp and hot
Decoct urine, become sandstone and block caused by urinary tract, therefore urinate involved and abstruse and interrupt.Hold high with western medical treatment urinary system calculus price
Unlike expensive, complication is more, TCM Therapy curative effect affirmative, non-invasive, untoward reaction are little, for vast urinary system calculus
Patient is accepted.
Doctor trained in Western medicine think urinary system calculus and dietary structure, Water intake, weather, heredity, metabolism, block and urinary tract infection
Relevant Deng many factors.And the traditional Chinese medical science thinks that the etiology and pathogenesis of urinary system calculus is mainly suffered from a deficiency of the kidney, bladder qi dysfunction, damp and hot accumulate
Tying, decoct body fluid, the with the passing of time moon tires out, and gathers and forms stone.Deepen continuously along with people treat the research of urinary system calculus and develop, treatment
Method mainly has clearing away heat-damp and promoting diuresis to arrange method, strengthening the loins and invigorating the kidney method, warming the kidney to promote diuresis method, Invigorating Qi, yin Method, regulating qi-flowing for activating stagnancy method, invigorating blood circulation
Stasis of blood method, relieving spasm to stop pain method etc..
Summary of the invention
In order to solve technical problem of the prior art, the invention provides a kind of Chinese drug-treated group treating urinary system calculus
Compound, it has the effect of diuresis promoting, regulating qi to disperse stagnation, promoting blood circulation and stopping pain, to including renal calculus, ureteral calculus, vesical calculus
And calculus of urethra etc. all has a therapeutic effect at interior urinary system calculus and evident in efficacy, toxic and side effects is little.It addition, the present invention
The preparation method raw material of Chinese medicine composition is easy to get, step is simple, reproducible.
For realizing the purpose of the application, the present invention is to be realized by following technical scheme.
On the one hand, the invention provides a kind of Chinese medicine composition treating urinary system calculus, it is by Herba Desmodii Styracifolii, chicken
Gold, Spora Lygodii rattan and Folium Pyrrosiae are made.
It has been found that on the basis of Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, add further Spora Lygodii,
Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae, Pulvis Talci and Radix Glycyrrhizae, can preferably play diuresis promoting, the effect of heat clearing away blood stasis removing.
As a preferred embodiment, the Chinese medicine system that the Chinese medicine composition of the present invention is made up of following weight portion
Become: Herba Desmodii Styracifolii 10-30 part, Endothelium Corneum Gigeriae Galli 10-30 part, Spora Lygodii rattan 10-30 part, Folium Pyrrosiae 15-40 part, Spora Lygodii 5-20 part, five
Oletum Trogopterori 5-20 part, Fructus Aurantii 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Pulvis Talci 5-20 part and Radix Glycyrrhizae 3-10 part.
It is highly preferred that the Chinese medicine that the Chinese medicine composition of the present invention is made up of following weight portion is made: Herba Desmodii Styracifolii 15-25
Part, Endothelium Corneum Gigeriae Galli 15-25 part, Spora Lygodii rattan 15-25 part, Folium Pyrrosiae 20-30 part, Spora Lygodii 12-18 part, Oletum Trogopterori 12-18 part, Fructus Aurantii
7-12 part, Pericarpium Citri Reticulatae 7-12 part, Pulvis Talci 12-18 part and Radix Glycyrrhizae 3-8 part.
Most preferably, the Chinese medicine that the Chinese medicine composition of the present invention is made up of following weight portion is made: Herba Desmodii Styracifolii 20 parts, chicken
Endothelium corneum 20 parts, 20 parts of Spora Lygodii rattan, Folium Pyrrosiae 25 parts, Spora Lygodii 15 parts, Oletum Trogopterori 15 parts, Fructus Aurantii 10 parts, Pericarpium Citri Reticulatae 10 parts, Pulvis Talci
15 parts and 5 parts of Radix Glycyrrhizae.
In the pharmaceutical composition of the present invention, source and effect of each raw material of Chinese medicine are described below.
Herba Desmodii Styracifolii: for leguminous plant Herba Desmodii Styracifolii Desmodium styracifolium (Osh.) Merr. dryly
Upper part.Nature and flavor are sweet, light, cool.Return liver, kidney, bladder warp.There is removing damp-heat, effect of inducing diuresis for treating stranguria syndrome.For pyretic stranguria, sand Stranguria,
Stranguria caused by urinary stone, difficulty and pain in micturition, edema oliguria, jaundice dark coloured urine, lithangiuria.
Endothelium Corneum Gigeriae Galli: for the dry inner wall of sandbag of Phasianidae animal man chicken Gallus gallus domesticus Brisson.
Nature and flavor are sweet, flat.Return spleen, stomach, small intestinal, bladder warp.There is invigorating the stomach and promoting digestion, effect of arresting seminal emission.Not disappearing for food stagnation, vomiting is rushed down
Dysentery, infantile malnutrition, the enuresis, seminal emission.
Herba lygodii: for the herb of Lygodiaceae plant Spora Lygodii.Nature and flavor are sweet, cold.There is heat-clearing and toxic substances removing, relieving stranguria by diuresis
Effect.Control urinary tract infection, lithangiuria, nebulousurine leukorrhagia, dysuria, oedema due to nephritis, jaundice due to damp-heat, cold, fever, cough, pharynx
Larynx swells and ache, enteritis, dysentery, scalds, erysipelas.
Folium Pyrrosiae: for Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, Folium Pyrrosiae Pyrrosia
Lingua (Thunb.) Farwell or the dried leaves of pyrrosia petiolosaChing Pyrrosia petiolosa (Christ) Ching.Nature and flavor
Sweet, bitter, it is slightly cold.Return lung, bladder warp.There is inducing diuresis for treating stranguria syndrome, effect of clearing away heat to stop bleeding.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urine is not
Logical, drench and drip puckery pain, spit blood, epistaxis, hematuria, metrorrhagia, dyspnea and cough due to lung-heat.
Spora Lygodii: for the drying and ripening spore of Lygodiaceae plant Spora Lygodii Lygodium japonicum (Thunb.) Sw.
Son.Nature and flavor are sweet, salty, cold.Return bladder, small intestine meridian.There is eliminating damp-heat, effect for the treatment of stranguria pain relieving.For pyretic stranguria, sand Stranguria, stranguria caused by urinary stone,
Stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Oletum Trogopterori: for flying squirrel section animal trogopterus xanthipes Trogopterus Xanthipes Milne-Edwards or flying squirrel
The dry feces of section animal little flying squirrel Pteromys volans L..Nature and flavor are sweet, temperature.There is promoting blood circulation to remove blood stasis, the merit of parch to black hemostasis
Effect.Having a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, curing postpartum bleeding is suffered from abdominal pain；Parch to black controls metrostaxis；Traumatic injury is controlled in external,
Serpentis, insect bite wound.
Fructus Aurantii: for rutaceae Citrus aurantium Linn. Citrus aurantium L. and the dry immature fruit of variety thereof.
Nature and flavor are bitter, pungent, sour, temperature.Return spleen, stomach warp.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.For breast coerce the stagnation of QI, distension pain,
Accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention；Gastroptosis, proctoptosis, sub-official prolapses.
Pericarpium Citri Reticulatae: for the drying and ripening fruit of rutaceae orange Citrus reticulata Blanco and variety thereof
Skin.Nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting,
Cough with copious phlegm.
Pulvis Talci: be Talcum through selected purification, pulverize, be dried and make.Nature and flavor are sweet, light, cold.Return bladder, lung, stomach warp.Tool
There are inducing diuresis for treating stranguria syndrome, clearing away summer-heat, effect of damp eliminating sore.For pyretic stranguria, stranguria caused by urinary stone, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea；
External treatment eczema, eczema, miliaria.
Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza
Inflata Bat. or the dry root of Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach
Warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, asthenia is weary
Power, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
In the Chinese medicine formula of the present invention, Herba Desmodii Styracifolii, Herba lygodii, Folium Pyrrosiae, Spora Lygodii, Pulvis Talci have heat clearing away and remove
Wet, effect of inducing diuresis for treating stranguria syndrome, clearing away heat to stop bleeding, Endothelium Corneum Gigeriae Galli, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae have effect of regulating qi-flowing for activating stagnancy, strengthening the spleen and stomach, and five
Oletum Trogopterori has effect of promoting blood circulation to remove blood stasis.All medicines merge, and play the effect of diuresis promoting, regulating qi to disperse stagnation, promoting blood circulation and stopping pain altogether, to including kidney
Calculus, ureteral calculus, vesical calculus and calculus of urethra etc. all have therapeutic effect at interior urinary system calculus, and curative effect shows
Work, toxic and side effects are little.
For the Chinese medicine composition of the present invention, the Chinese medicine that this area is conventional can be made after extracting active component further
Type, such as decoction, pill, tablet, capsule, drop pill, powder, granule, oral liquid etc..
Second aspect, it is provided that for the method preparing pharmaceutical composition of the present invention, the method comprises the steps:
A, weigh Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae, Pulvis Talci and
Radix Glycyrrhizae, standby；
B, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Pulvis Talci are pulverized the most respectively, then cross 100-200 mesh sieve and obtain fine powder, standby；
C, by Herba Desmodii Styracifolii, Spora Lygodii rattan, Folium Pyrrosiae, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae pulverize after mix, add 6-10 times
The soak by water of volume twice, 2-5 hour for the first time, 0.5-3 hour for the second time, collecting decoction also retained filtering residue, filtered decocting liquid, filter
It is standby that liquid is evaporated to the clear paste that relative density is 1.12-1.18 (60 DEG C)；
D, the filtering residue of step C is added the 45-60% ethanol of 4-8 times of volume, reflux, extract, 2 times, each 1-3 hour, filter,
Merging filtrate, then decompression is distilled off ethanol, and it is standby to be concentrated into the clear paste that relative density is 1.12-1.18 (60 DEG C)；
E, the clear paste of step C and step D is merged, stir, be heated to 50-80 DEG C and cross the filter of 200-400 mesh sieve while hot
Crossing, filtrate is spray-dried, and obtains spray powder, is subsequently adding the fine powder of step B, crosses 100-200 mesh sieve mix homogeneously, i.e.
?.
For the spray drying of step E, preferred condition is: outlet temperature 80-100 DEG C, inlet temperature 130-160 DEG C,
Flow velocity 0.2-0.6kg/min, feed temperature 23-30 DEG C.
For the mixed-powder of step E gained, it is optionally added into pharmaceutically acceptable adjuvant, makes decoction, pill, sheet
Agent, capsule, drop pill, powder, granule, oral liquid.
Further, the Chinese medicine composition of the present invention use in the medicine of preparation treatment urinary system calculus is additionally provided
On the way.
Compared with prior art, the present invention include following advantage:
(1), the present invention on the basis of China's Chinese medicine, scientific and reasonable formula, Herba Desmodii Styracifolii, Herba lygodii, Folium Pyrrosiae,
Spora Lygodii, Pulvis Talci have effect of removing damp-heat, inducing diuresis for treating stranguria syndrome, clearing away heat to stop bleeding, and Endothelium Corneum Gigeriae Galli, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae have
Regulating qi-flowing for activating stagnancy, effect of strengthening the spleen and stomach, Oletum Trogopterori has effect of promoting blood circulation to remove blood stasis.All medicines merge, and play diuresis promoting, circulation of qi promoting altogether
The stasis of blood, the effect of promoting blood circulation and stopping pain, to the urinary system including including renal calculus, ureteral calculus, vesical calculus and calculus of urethra etc.
Calculus all has a therapeutic effect, and evident in efficacy, toxic and side effects is little.
(2), the Chinese medicine composition of the present invention after water boiling and extraction, active constituent content is higher, and can make further
The patients such as standby one-tenth decoction, pill, tablet, capsule, drop pill, powder, granule, oral liquid are easier to the form accepted, from
And the drug compliance of patient is more preferable.
(3), be easy to get for the method raw material preparing Chinese medicine preparation of the present invention, step is simple, reproducible, meet industry
The needs produced.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with the embodiment tool to the present invention
Body embodiment is clearly and completely described.
Embodiment 1:
Formula and weight portion composition: Herba Desmodii Styracifolii 20 parts, Endothelium Corneum Gigeriae Galli 20 parts, 20 parts of Spora Lygodii rattan, Folium Pyrrosiae 25 parts, Spora Lygodii
15 parts, Oletum Trogopterori 15 parts, Fructus Aurantii 10 parts, Pericarpium Citri Reticulatae 10 parts, Pulvis Talci 15 parts and 5 parts of Radix Glycyrrhizae.
Preparation method: A, weigh Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae,
Pulvis Talci and Radix Glycyrrhizae, standby；B, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Pulvis Talci are pulverized the most respectively, then cross 100 mesh sieves and obtain fine powder,
Standby；C, by Herba Desmodii Styracifolii, Spora Lygodii rattan, Folium Pyrrosiae, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae pulverize after mix, add 6 times of volumes
Soak by water twice, 3 hours for the first time, 1 hour for the second time, collecting decoction also retained filtering residue, filtered decocting liquid, and filtrate reduced in volume is extremely
Relative density is that the clear paste of 1.15 (60 DEG C) is standby；D, the filtering residue of step C is added 60% ethanol of 6 times of volumes, reflux, extract, 2
Secondary, each 1 hour, filter, merging filtrate, then decompression is distilled off ethanol, and to be concentrated into relative density be 1.15 (60 DEG C)
Clear paste standby；E, the clear paste of step C and step D is merged, stir, be heated to 60 DEG C and cross 200 mesh sieves while hot and filter, filter
Liquid is spray-dried, and obtains spray powder, and spray drying condition is: outlet temperature 80 DEG C, inlet temperature 130 DEG C, flow velocity
0.3kg/min, feed temperature 25 DEG C, it is subsequently adding the fine powder of step B, crosses 100 mesh sieve mix homogeneously；Add appropriate lactose, wheat
Bud dextrin and magnesium stearate, mix homogeneously, direct compression, obtain tablet.
Embodiment 2:
Formula and weight portion composition: Herba Desmodii Styracifolii 15 parts, Endothelium Corneum Gigeriae Galli 25 parts, 25 parts of Spora Lygodii rattan, Folium Pyrrosiae 22 parts, Spora Lygodii
16 parts, Oletum Trogopterori 16 parts, Fructus Aurantii 8 parts, Pericarpium Citri Reticulatae 8 parts, Pulvis Talci 16 parts and 4 parts of Radix Glycyrrhizae.
Preparation method: A, weigh Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae,
Pulvis Talci and Radix Glycyrrhizae, standby；B, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Pulvis Talci are pulverized the most respectively, then cross 200 mesh sieves and obtain fine powder,
Standby；C, by Herba Desmodii Styracifolii, Spora Lygodii rattan, Folium Pyrrosiae, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae pulverize after mix, add 8 times of volumes
Soak by water twice, 4 hours for the first time, 2 hours for the second time, collecting decoction also retained filtering residue, filtered decocting liquid, and filtrate reduced in volume is extremely
Relative density is that the clear paste of 1.12 (60 DEG C) is standby；D, the filtering residue of step C is added 50% ethanol of 6 times of volumes, reflux, extract, 2
Secondary, each 2 hours, filter, merging filtrate, then decompression is distilled off ethanol, and to be concentrated into relative density be 1.12 (60 DEG C)
Clear paste standby；E, the clear paste of step C and step D is merged, stir, be heated to 80 DEG C and cross 200 mesh sieves while hot and filter, filter
Liquid is spray-dried, and obtains spray powder, and spray drying condition is: outlet temperature 100 DEG C, inlet temperature 150 DEG C, flow velocity
0.5kg/min, feed temperature 28 DEG C, it is subsequently adding the fine powder of step B, crosses 200 mesh sieve mix homogeneously；Add appropriate corn starch
And Pulvis Talci, mix homogeneously, fill to capsule shells, obtain capsule.
Embodiment 3:
Formula and weight portion composition: Herba Desmodii Styracifolii 23 parts, Endothelium Corneum Gigeriae Galli 23 parts, 23 parts of Spora Lygodii rattan, Folium Pyrrosiae 23 parts, Spora Lygodii
12 parts, Oletum Trogopterori 12 parts, Fructus Aurantii 10 parts, Pericarpium Citri Reticulatae 10 parts, Pulvis Talci 12 parts and 6 parts of Radix Glycyrrhizae.
Preparation method: A, weigh Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae,
Pulvis Talci and Radix Glycyrrhizae, standby；B, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Pulvis Talci are pulverized the most respectively, then cross 100 mesh sieves and obtain fine powder,
Standby；C, by Herba Desmodii Styracifolii, Spora Lygodii rattan, Folium Pyrrosiae, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae pulverize after mix, add 7 times of volumes
Soak by water twice, 2 hours for the first time, 2 hours for the second time, collecting decoction also retained filtering residue, filtered decocting liquid, and filtrate reduced in volume is extremely
Relative density is that the clear paste of 1.18 (60 DEG C) is standby；D, the filtering residue of step C is added 45% ethanol of 6 times of volumes, reflux, extract, 2
Secondary, each 3 hours, filter, merging filtrate, then decompression is distilled off ethanol, and to be concentrated into relative density be 1.18 (60 DEG C)
Clear paste standby；E, the clear paste of step C and step D is merged, stir, be heated to 50 DEG C and cross 200 mesh sieves while hot and filter, filter
Liquid is spray-dried, and obtains spray powder, and spray drying condition is: outlet temperature 90 DEG C, inlet temperature 140 DEG C, flow velocity
0.6kg/min, feed temperature 26 DEG C, it is subsequently adding the fine powder of step B, crosses 100 mesh sieve mix homogeneously；Add appropriate Fructus Hordei Germinatus to stick with paste
Essence, starch and Mel, make pill after mix homogeneously.
Test example 1: animal model test
1, the impact on kidney of rats calculus
(1), test method: randomly select 60 healthy Wistar rats, body weight 180-250g, be randomly divided into 4 groups, often group
15.Blank group: 15, gavage normal saline；Model control group: 15, gavage normal saline；Positive controls: 15
Only, the aqueous solution of gavage compound recipe SHILINTONG PIAN, dosage 25g/kg；Of the present invention group: 15, gavage the embodiment of the present application 1 tablet
Aqueous solution, dosage 25g/kg.Often group rat gavage every day 1 time, continuous 30 days.During raising, model control group, positive controls
With of the present invention group in 100g feedstuff add ethylene glycol 2g and ammonium chloride 1g, and weekly intramuscular injection vitamin D3 once, dosage 3
Ten thousand units/kg, to form renal calculus model.Put to death experimental animal after off-test, take out double kidney, longitudinally cut open, observe kidney and cut open
Face is with or without obvious crystalline deposit thing and free calculus or calcified plaque.It is divided into according to lithogenous how many and kidney injury degree
5 grades below, and model control group, positive controls and of the present invention group are given a mark.
I level: renal cortex, medullary substance and renal papillae are without visible calculus and crystalline deposit thing, the change without exception of kidney profile
Change, remember 0 point；
II level: be dispersed in crystalline deposit thing seen from renal cortex or medullary substance on a small quantity, remembers 1 point；
III level: crystalline deposit thing seen from renal cortex, medullary substance and renal pelvis or have little free crystallization, remembers 2 points；
IV level: relatively polycrystalline seen from kidney section, and have free calculus, calcified plaque seen from renal papillae, pyelectasis is amassed
Water, remembers 3 points；
V level: mass crystallization seen from renal cortex, medullary substance, has free calculus, calcified plaque seen from renal papillae, and renal pelvis is obvious
Expansion hydrops, remembers 4 points.
(2), result of the test: as shown in table 1, of the present invention group with model control group (P < 0.01) and positive controls (P <
0.05) having significant difference, the Chinese medicine composition of the present invention can substantially prevent the renal calculus that ethylene glycol and ammonium chloride etc. induce
Formed, and make the calculus rate of rat decrease.
Each group of impact on kidney of rats calculus of table 1
| Group | Size of animal (only) | Dosage (g/kg) | Renal calculus scoring (dividing) | Calculus rate (%) |
| Blank group | 15 | 0 | 0 | 0 |
| Model control group | 15 | 0 | 3.02±1.58 | 91.2% |
| Positive controls | 15 | 25.0 | 0.43±0.54 | 30.7% |
| Of the present invention group | 15 | 25.0 | 0.29±0.21 | 21.5% |
2, the impact on rat urine
(1), test method: randomly select 45 healthy Wsiatar rats, body weight 180-250g, be randomly divided into 3 groups, empty
White matched group, positive controls and other 15 of instant component.Fasting can't help water 10 days, and then every rat oral gavage gives 5%
Glucose saline 3mL/100g, after 30 minutes, to blank group gavage normal saline, to positive controls gavage compound recipe stranguria caused by urinary stone
The aqueous solution of logical sheet, dosage 25g/kg, the aqueous solution to of the present invention group of gavage the embodiment of the present application 1 tablet, dosage 25g/kg.Give
Oppress rat lower abdomen after medicine, drain remaining urine, be subsequently placed in metabolic cage, collect the urine of 5 hours, and oppress rat lower abdomen and drain
Remaining urine, measures the volume of urine of each group of rat respectively.
(2), result of the test: as shown in table 2, of the present invention group with blank group (P < 0.01) and positive controls (P <
0.05) having significant difference, the Chinese medicine composition of the present invention can substantially increase the voided volume of rat, shows have significant profit
Urine effect.
Each group of impact on rat urine of table 2
3, the impact on rat ears swelling
(1), test method: randomly select 45 healthy kunming mices, body weight 22-30g, be randomly divided into 3 groups.Blank
Group: 15, gavage normal saline；Positive controls: 15, the aqueous solution of gavage compound recipe SHILINTONG PIAN, dosage 25g/kg；This
Bright group: 15, the aqueous solution of gavage the embodiment of the present application 1 tablet, dosage 25g/kg.After being administered 1 hour, to a left side for every rat
Ear is injected 2% Oleum Tiglii mixture 0.05mL and is caused left ear inflammation swelling, and auris dextra is as comparison.After 4 hours, put to death experimental animal, cut
Lower two ears, lay auricle respectively, and weigh the left and right ear of mice, using its difference as inflammation with card punch at same position
Property swelling degree, calculate swelling inhibition percentage.
(2), result of the test: as shown in table 3, of the present invention group with blank group (P < 0.01) and positive controls (P <
0.05) having significant difference, the Chinese medicine composition of the present invention has obvious inhibitory action to Oleum Tiglii induced mice ear swelling.
Each group of impact on mice ear of table 3
| Group | Size of animal (only) | Dosage (g/kg) | Left ear swelling degree (mg) | Suppression ratio (%) |
| Blank group | 15 | 0 | 19.8±1.58 | 0 |
| Positive controls | 15 | 25.0 | 13.5±1.76 | 35.4% |
| Of the present invention group | 15 | 25.0 | 12.3±1.44 | 48.5% |
Test example 2: model case
Model case 1: Xiao, man, 38 years old, the waist and belly distending pain several months on the left of main suit, Zuo Shen district kowtowed pain, and CT examination finds a left side
Kidney has several pieces of calculus, diameter the maximum 0.9cm, reckling 0.2cm, is diagnosed as left kidney Calculus.Take the embodiment of the present application 1
Tablet in treatment, each 2,3 times on the one, and advise every daily drink 2000ml and do jumping exercise more.After treating 3 days, discharge straight
5 pieces of footpath about 0.3cm calculus, after continuing to take said medicine treatment 5 days, discharges 3 pieces of diameter about 0.8cm calculus smoothly, continues clothes
Consolidated with 2 weeks.Patient's waist and belly pain symptom disappears, and check CT does not finds calculus light blocking shadow, with anti-1 year without recurrence.
Model case 2: the Meng, female, 47 years old, main suit urinated difficulty, and band blood in urine, hospital diagnosis is renal calculus, operative treatment
After alleviated, but recur after 1 month and increase the weight of.Take the tablet in treatment of the embodiment of the present application 1, each 2,3 times on the one, and
Advise every daily drink 2000ml and do jumping exercise more.After treating 7 days, frequent micturition and hematuria significantly reduce, and urine is normal, continue clothes
With 2 weeks, above-mentioned symptom was wholly absent, and had no calculus through CT check.
Model case 3: Wang, man, 51 years old, there is agnogenic right lumbar region angor in main suit before 2 months, after lying up
Spontaneous remission, on the right side of ultrasound diagnosis discovery, there are many pieces of calculus (4mm × 4mm) in kidney portion.Take the tablet in treatment of the embodiment of the present application 1,
Each 2,3 times on the one, and advise every daily drink 2000ml and do jumping exercise more.After treating 3 weeks check B ultrasonic show on the right side of kidney tie
Stone disappears.
Model case 4: Jiang, man, 23 years old, main suit found ureteral calculus 2 years, abdomen pain slight pain during initial onset
Bitterly, abdominal colic occur recently during outbreak, the right kidney of ultrasound diagnosis and ureter have many pieces of 8 × 6mm calculus.Take the application to implement
The tablet in treatment of example 1, each 2,3 times on the one, and advise every daily drink 2000ml and do jumping exercise more.B is checked after treating 3 weeks
Super display calculus is wholly absent.
Claims (10)
1. the Chinese medicine composition treating urinary system calculus, it is characterised in that by Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan and
Folium Pyrrosiae is made.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that by Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae,
Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae, Pulvis Talci and Radix Glycyrrhizae are made.
3. Chinese medicine composition as claimed in claim 1, it is characterised in that be made up of the Chinese medicine of following weight: wide money
Grass 10-30 part, Endothelium Corneum Gigeriae Galli 10-30 part, Spora Lygodii rattan 10-30 part, Folium Pyrrosiae 15-40 part, Spora Lygodii 5-20 part, Oletum Trogopterori 5-20
Part, Fructus Aurantii 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Pulvis Talci 5-20 part and Radix Glycyrrhizae 3-10 part.
4. Chinese medicine composition as claimed in claim 3, it is characterised in that be made up of the Chinese medicine of following weight: wide money
Grass 15-25 part, Endothelium Corneum Gigeriae Galli 15-25 part, Spora Lygodii rattan 15-25 part, Folium Pyrrosiae 20-30 part, Spora Lygodii 12-18 part, Oletum Trogopterori 12-18
Part, Fructus Aurantii 7-12 part, Pericarpium Citri Reticulatae 7-12 part, Pulvis Talci 12-18 part and Radix Glycyrrhizae 3-8 part.
5. Chinese medicine composition as claimed in claim 4, it is characterised in that be made up of the Chinese medicine of following weight: wide money
Grass 20 parts, Endothelium Corneum Gigeriae Galli 20 parts, 20 parts of Spora Lygodii rattan, Folium Pyrrosiae 25 parts, Spora Lygodii 15 parts, Oletum Trogopterori 15 parts, Fructus Aurantii 10 parts, Pericarpium Citri Reticulatae 10
Part, Pulvis Talci 15 parts and 5 parts of Radix Glycyrrhizae.
6. the Chinese medicine composition as described in one of claim 1-5, it is characterised in that dosage form is pill, tablet, capsule, drop pill
Agent, powder, granule, oral liquid.
7. the preparation method of the Chinese medicine composition as described in one of claim 1-5, it is characterised in that comprise the steps:
A, weigh Herba Desmodii Styracifolii, Endothelium Corneum Gigeriae Galli, Spora Lygodii rattan, Folium Pyrrosiae, Spora Lygodii, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae, Pulvis Talci and Radix Glycyrrhizae,
Standby；
B, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Pulvis Talci are pulverized the most respectively, then cross 100-200 mesh sieve and obtain fine powder, standby；
C, by Herba Desmodii Styracifolii, Spora Lygodii rattan, Folium Pyrrosiae, Oletum Trogopterori, Fructus Aurantii, Pericarpium Citri Reticulatae and Radix Glycyrrhizae pulverize after mix, add 6-10 times of volume
Soak by water twice, 2-5 hour for the first time, 0.5-3 hour for the second time, collecting decoction also retained filtering residue, filtered decocting liquid, and filtrate subtracts
It is standby that pressure is concentrated into the clear paste that relative density is 1.12-1.18 (60 DEG C)；
D, the filtering residue of step C is added the 45-60% ethanol of 4-8 times of volume, reflux, extract, 2 times, each 1-3 hour, filters, merges
Filtrate, then decompression is distilled off ethanol, and it is standby to be concentrated into the clear paste that relative density is 1.12-1.18 (60 DEG C)；
E, the clear paste of step C and step D is merged, stir, be heated to 50-80 DEG C and cross 200-400 mesh sieve while hot and filter, filter
Liquid is spray-dried, and obtains spray powder, is subsequently adding the fine powder of step B, crosses 100-200 mesh sieve mix homogeneously, to obtain final product.
8. preparation method as claimed in claim 7, it is characterised in that the spray drying condition of step E is: outlet temperature 80-
100 DEG C, inlet temperature 130-160 DEG C, flow velocity 0.2-0.6kg/min, feed temperature 23-30 DEG C.
9. preparation method as claimed in claim 7, it is characterised in that the mixed-powder of step E gained is optionally added into pharmaceutically
Acceptable adjuvant, makes decoction, pill, tablet, capsule, drop pill, powder, granule, oral liquid.
10. the purposes in the medicine of preparation treatment urinary system calculus of the Chinese medicine composition as described in one of claim 1-5.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714778A (en) * | 2017-11-28 | 2018-02-23 | 陈能海 | A kind of Chinese medicine composition for treating calculus and preparation method thereof |
| CN113876849A (en) * | 2021-11-09 | 2022-01-04 | 张兴东 | Traditional Chinese medicine composition for removing calculus and preparation process thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475777A (en) * | 2010-11-23 | 2012-05-30 | 鲜丹科 | Urolith elimination |
| CN104758702A (en) * | 2015-04-22 | 2015-07-08 | 李丽丽 | Liver soothing and bladder relieving agent for treating gallstone and preparation method of agent |
-
2016
- 2016-09-14 CN CN201610825333.7A patent/CN106266109B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475777A (en) * | 2010-11-23 | 2012-05-30 | 鲜丹科 | Urolith elimination |
| CN104758702A (en) * | 2015-04-22 | 2015-07-08 | 李丽丽 | Liver soothing and bladder relieving agent for treating gallstone and preparation method of agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714778A (en) * | 2017-11-28 | 2018-02-23 | 陈能海 | A kind of Chinese medicine composition for treating calculus and preparation method thereof |
| CN113876849A (en) * | 2021-11-09 | 2022-01-04 | 张兴东 | Traditional Chinese medicine composition for removing calculus and preparation process thereof |
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Inventor after: Xie Xiaopeng Inventor after: Xie Guoguang Inventor after: Xie Wei Inventor before: Xie Guoguang Inventor before: Xie Wei Inventor before: Xie Tao |