CN104667183A - Medicine preparation for treating damp-heat evil stagnation type pyogenic osteomyelitis and preparation method of medicine preparation - Google Patents

Abstract

The invention discloses a medicine preparation for treating damp-heat evil stagnation type pyogenic osteomyelitis and a preparation method of the medicine preparation. The medicine preparation comprises the following raw medicinal materials: Chinese tamarisk, simpleleaf shrub chastetree fruit, common ducksmeat herb, mongolian snakegourd root, common dayflower herb, hematite, cape jasmine fruit, root of lobed kudzuvine, baikal skullcap root, light yellow sophora root, densefruit pittany root-bark, meadowrue root and rhizome, honeysuckle flower, glabrous greenbrier rhizome, mongolian dandelion herb, Japanese honeysuckle stem, common andrographis herb, belvedere fruit, heartleaf houttuynia herb, philippine violet herb, flower of Indian dendranthema, wild buckwheat rhizome, stem of sargentgloryvine, Chinese rose flower, root of largeleaf gentian, fourstamen stephania root, mulberry twig, coptis chinensis, bark of Oriental variegated coralbean, stem of Chinese starjasmine, erodium stephanianum willd, chuanlong yam, Chinese taxillus twig, Chinese photinia leaf, coix seed, seed of pepperweed, shepherdspurse herb, szechuan lovage rhizome, white ramping fumitory, turmeric, frankincense, myrrh, beautiful sweetgum resin, Chinese trumpetcreeper flower, suberect spatholobus stem and motherwort herb. The medicine preparation disclosed by the invention has the beneficial effects that the medicine preparation has the effects of clearing heat and removing dampness, and removing blood stasis and dredging collaterals, is mainly used for treating damp-heat evil stagnation type pyogenic osteomyelitis, adopts the theory of conventional traditional Chinese medicines, has the characteristics of strong pertinence, shortened disease course, short treatment course and significant curative effect by regulating the overall immunity, can also play roles in expelling pus and relieving pain as well as preventing infection, and has the advantages of no toxic or side effects.

Description

Treat pharmaceutical preparation of the stagnant type suppurative osteomyelitis of damp and hot heresy and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly treat pharmaceutical preparation of the stagnant type suppurative osteomyelitis of damp and hot heresy and preparation method thereof.

Background technology

Suppurative osteomyelitis refers to the osteomyelitis because various infective agent causes, and is divided into acute and chronic two kinds with course of disease length.Acute osteomyelitis based on bone absorption, destroy, chronic osteomyelitis with sequestrum formed and area of new bone be formed as main.

The cause of disease of suppurative osteomyelitis: suppurative: 1. haematogenous: suppurative bacterium is by circulating in local sclerotin generation pathological changes, and be hematogenous osteomyelitis, infection focus is often tonsillitis, otitis media, furuncle, carbuncle etc.2. traumatic: to be direct infection, the open fracture caused by firearm injury or other wound, wound contamination, infect without thorough debridement in time, be chronic osteomyeli tis, when B&J hands is main, sterile working is tight, also can cause pyogenic infection.3. near skeleton, soft tissue infection's diffusion causes, and as felon, if treat not in time, can cause digital osteomyelitis.

The clinical manifestation of suppurative osteomyelitis: suppurative osteomyelitis Patients with Acute often has and feels cold, heating, body temperature sometimes can up to about 40 degree, there is pain in ill position, and progressively aggravate, in persistence severe pain, local has red, swollen, heat, the inflammatory symptoms such as pain, and disorder of limb ' s activity, if now treat not thorough, chronic osteomyelitis can be transformed into.Chronic phase suppurative osteomyelitis patient, wound usually pus is few, obvious pain is not had yet, sometimes may oneself heal, but interval regular period wound again can be red and swollen, pain, transference cure after ulceration, recurrent exerbation, forms prolonged fistula of not healing, sometimes have little bone cips to flow out from wound, x-ray takes the photograph sheet inspection, need could find the shade of abscess or bone destruction in morbidity after 10 days, and slow person falls ill and just can see the performance of bone destruction after surrounding, chronic phase, carries out x-ray film making and checks, can understand with or without " sequestrum " and extent of disease.

The traditional Chinese medical science is thought, suppurative osteomyelitis belongs to the categories such as motherland's medical science " pyogenic infection of the bone ".Pyogenic infection of the bone is the purulent disease that a kind of poison is evil deep, be attached to bone.Be characterized in being mainly in long bone of limbs, local is fat swollen, and attached muscle bone, and what push away does not move, and to the bone, after bursting, pus is dripping, not easily closes up, can become sinus tract for pain, damage muscles and bones." preemergency prescriptions worth thousand gold " cloud: " with it without broken, attached bone becomes pus, therefore named pyogenic infection of the bone." primary disease is different according to site of pathological change, has different names again: as raw at large leg outer side, be pyogenic infection of the bone; Be born in femoribus internus, be pyogenic infection of the bone; Only raw at stock shank, cry abscess on the thigh or shank etc.

The clinical syndrome of suppurative osteomyelitis is divided into: the 1. stagnant type of damp and hot heresy: onset is hurried, and to the bone, fat swollen bone is swollen for limb pain, and the micro-red slight fever of skin is scorching hot by it; The high heat of shiver with cold, headache poor appetite, xerostomia, urinates red; Red tongue, yellow and greasy fur, slippery and rapid pulse.2. extreme noxious heat: after onset is about 1-2 week, high heat is persistent, and suffering limb is fat swollen red red, severe pain, and skin lifts red scorching hot, and has fluctuation; Red tongue, yellow fur, full and rapid pulse.3. septicopyemia erosion bone type: become to leak after bursting, pus is not to the utmost dripping, does not close up for a long time, or time when sending out more, suffering limb amyotrophy, can touch massive bones, often can touch coarse sequestrum with pin check; Companion's spiritlessness and weakness, complexion light is white, dizzy cardiopalmus, low grade fever; Body of the tongue is light red, white and thin fur, soft and thready pulse.

Western medical treatment suppurative osteomyelitis: the treatment of (one) acute hematogenous suppurative osteomyelitis.1. whole body supporting treatment: comprise and fully have a rest and well nurse, note water, electrolyte balance, repeatedly transfuse blood on a small quantity, there is decubital ulcer and oral cavity infection etc. in prevention, give the digestible diet being imbued with protein and vitamin, use analgesics, patient is had a rest preferably.2. Drug therapy: adopt in time enough and effective antibacterials, start to select broad-spectrum antibiotic, normal more than two kinds use in conjunction, result and the therapeutic effect of foundation antibacterial culturing and drug sensitivity test more later adjust.3. topical therapeutic: with suitable clamping plate or plaster slab restraint, lifting affected limb, to prevent deformity, reduces pain and avoids pathological fracture.As abscess is not obvious, serious symptom, medicine can not control in 24 ~ 48 hours, suffered from bone local obviously tenderness, should incision and drainage early, in order to avoid pus spreads voluntarily, caused extensive bone destruction.(2) control of firearm injury suppurative osteomyelitis: firearm injury makes soft tissue and sclerotin sustain damage and pollute, and infection potential is very large.Therefore, after wound, debridement prevention infection to be carried out in time, the resistance of enhancing body, make open fracture become closed fracture.Wound during Dressing Change, keeps drain, enhancing body resistance and use antimicrobial drug prevention infection.To wound the open fracture caused, necessary thoroughly debridement, not sew up wound, in order to drain.To non-gunshot fracture, if carry out debridement in time, answer sew up wound, place drainage strip 48 hours, strive for primary wound healing, make fracture transfer closure to.Occur if infect, wound should be expanded as early as possible, in order to drain, and strengthen whole body supporting treatment and anti-infective therapy.

But, western medical treatment suppurative osteomyelitis is longer for the course for the treatment of, the adverse effectes such as antibiotic, analgesia class are more, dosage is wayward, if the delay state of an illness can cause infection, suppuration etc. to increase the weight of the state of an illness, easily produce drug resistance while long-term extensive application medicine brings toxic and side effects, clinical efficacy is not satisfactory; Operative treatment is comparatively large to body wound, reduces the quality of life etc. of patient.

Summary of the invention

Technical problem to be solved by this invention is, provide pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy for the treatment of and preparation method thereof, the present invention has clearing away heat and eliminating dampness, effect of clots absorbing dredging collateral, cures mainly the stagnant type suppurative osteomyelitis of damp and hot heresy, utilizes Traditional Chinese medical theory, by regulating overall immunity, by force pointed, shorten the course of disease, treatment short treating period, feature evident in efficacy, can also play suppuration pain relieving, protect from infection, the advantage such as have no side effect.

In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical preparation for the treatment of the stagnant type suppurative osteomyelitis of damp and hot heresy, wherein, comprise following raw medicinal material: Ramulus et Folium Tamaricis, Fructus Viticis, Herba Spirodelae, Radix Trichosanthis, Herba Commelinae, Haematitum, Fructus Gardeniae, Radix Puerariae, Radix Scutellariae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix et Rhizoma Thalictri, Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Taraxaci, Caulis Lonicerae, Herba Andrographis, the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Rhizoma Coptidis, Cortex erythrinae, Caulis Trachelospermi, geranium, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Semen Coicis, Semen Lepidii (Semen Descurainiae), Herba Capsellae, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Olibanum, Myrrha, Resina Liquidambaris, Flos Campsis, Caulis Spatholobi and Herba Leonuri.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 10 ~ 25 parts, Fructus Viticis 12 ~ 24 parts, 15 ~ 30 parts, Herba Spirodelae, Radix Trichosanthis 16 ~ 32 parts, Herba Commelinae 18 ~ 35 parts, Haematitum 10 ~ 30 parts, Fructus Gardeniae 14 ~ 26 parts, Radix Puerariae 11 ~ 24 parts, Radix Scutellariae 12 ~ 30 parts, Radix Sophorae Flavescentis 12 ~ 25 parts, Cortex Dictamni 18 ~ 32 parts, Radix et Rhizoma Thalictri 10 ~ 24 parts, Flos Lonicerae 13 ~ 31 parts, Rhizoma Smilacis Glabrae 10 ~ 25 parts, Herba Taraxaci 18 ~ 30 parts, Caulis Lonicerae 10 ~ 22 parts, Herba Andrographis 8 ~ 21 parts, the Fructus Kochiae 14 ~ 32 parts, Herba Houttuyniae 17 ~ 34 parts, Herba Violae 15 ~ 28 parts, Flos Chrysanthemi Indici 13 ~ 33 parts, Rhizoma Fagopyri Dibotryis 11 ~ 30 parts, Caulis Sargentodoxae 18 ~ 32 parts, Flos Rosae Chinensis 16 ~ 30 parts, Radix Gentianae Macrophyllae 9 ~ 23 parts, Radix Stephaniae Tetrandrae 10 ~ 24 parts, Ramulus Mori 13 ~ 31 parts, Rhizoma Coptidis 18 ~ 30 parts, Cortex erythrinae 12 ~ 24 parts, Caulis Trachelospermi 11 ~ 30 parts, geranium 8 ~ 21 parts, Rhizoma Dioscoreae Nipponicae 13 ~ 30 parts, Herba Taxilli 12 ~ 23 parts, Folium Photiniae (Folium Photiniae serrulatae) 16 ~ 32 parts, Semen Coicis 19 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 17 ~ 35 parts, 12 ~ 24 parts, Herba Capsellae, Rhizoma Chuanxiong 17 ~ 31 parts, Rhizoma Corydalis 13 ~ 27 parts, 19 ~ 30 parts, Rhizoma Curcumae Longae, Olibanum 14 ~ 25 parts, Myrrha 13 ~ 24 parts, Resina Liquidambaris 14 ~ 26 parts, Flos Campsis 11 ~ 24 parts, Caulis Spatholobi 13 ~ 26 parts and Herba Leonuri 10 ~ 20 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 12 ~ 23 parts, Fructus Viticis 15 ~ 22 parts, 18 ~ 26 parts, Herba Spirodelae, Radix Trichosanthis 19 ~ 30 parts, Herba Commelinae 20 ~ 33 parts, Haematitum 10 ~ 22 parts, Fructus Gardeniae 16 ~ 24 parts, Radix Puerariae 15 ~ 23 parts, Radix Scutellariae 14 ~ 28 parts, Radix Sophorae Flavescentis 16 ~ 24 parts, Cortex Dictamni 19 ~ 30 parts, Radix et Rhizoma Thalictri 12 ~ 22 parts, Flos Lonicerae 15 ~ 27 parts, Rhizoma Smilacis Glabrae 13 ~ 24 parts, Herba Taraxaci 20 ~ 28 parts, Caulis Lonicerae 14 ~ 20 parts, Herba Andrographis 9 ~ 20 parts, the Fructus Kochiae 18 ~ 30 parts, Herba Houttuyniae 19 ~ 32 parts, Herba Violae 16 ~ 25 parts, Flos Chrysanthemi Indici 14 ~ 30 parts, Rhizoma Fagopyri Dibotryis 15 ~ 28 parts, Caulis Sargentodoxae 18 ~ 28 parts, Flos Rosae Chinensis 18 ~ 28 parts, Radix Gentianae Macrophyllae 10 ~ 22 parts, Radix Stephaniae Tetrandrae 12 ~ 20 parts, Ramulus Mori 14 ~ 30 parts, Rhizoma Coptidis 20 ~ 28 parts, Cortex erythrinae 14 ~ 22 parts, Caulis Trachelospermi 13 ~ 27 parts, geranium 9 ~ 20 parts, Rhizoma Dioscoreae Nipponicae 15 ~ 28 parts, Herba Taxilli 15 ~ 20 parts, Folium Photiniae (Folium Photiniae serrulatae) 18 ~ 30 parts, Semen Coicis 20 ~ 28 parts, Semen Lepidii (Semen Descurainiae) 20 ~ 30 parts, 15 ~ 22 parts, Herba Capsellae, Rhizoma Chuanxiong 18 ~ 30 parts, Rhizoma Corydalis 15 ~ 24 parts, 20 ~ 28 parts, Rhizoma Curcumae Longae, Olibanum 15 ~ 24 parts, Myrrha 14 ~ 22 parts, Resina Liquidambaris 15 ~ 25 parts, Flos Campsis 13 ~ 22 parts, Caulis Spatholobi 14 ~ 24 parts and Herba Leonuri 12 ~ 18 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 16 parts, Fructus Viticis 14 parts, 26 parts, Herba Spirodelae, Radix Trichosanthis 28 parts, Herba Commelinae 25 parts, Haematitum 14 parts, Fructus Gardeniae 16 parts, Radix Puerariae 18 parts, Radix Scutellariae 22 parts, Radix Sophorae Flavescentis 24 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 25 parts, Rhizoma Smilacis Glabrae 19 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 20 parts, Herba Andrographis 18 parts, the Fructus Kochiae 17 parts, Herba Houttuyniae 24 parts, Herba Violae 22 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 26 parts, Caulis Sargentodoxae 22 parts, Flos Rosae Chinensis 25 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 21 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 27 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 18 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 25 parts, Herba Taxilli 15 parts, Folium Photiniae (Folium Photiniae serrulatae) 26 parts, Semen Coicis 24 parts, Semen Lepidii (Semen Descurainiae) 22 parts, 20 parts, Herba Capsellae, Rhizoma Chuanxiong 19 parts, Rhizoma Corydalis 25 parts, 28 parts, Rhizoma Curcumae Longae, Olibanum 20 parts, Myrrha 18 parts, Resina Liquidambaris 24 parts, Flos Campsis 16 parts, Caulis Spatholobi 24 parts and Herba Leonuri 15 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 17 parts, Fructus Viticis 19 parts, 22 parts, Herba Spirodelae, Radix Trichosanthis 25 parts, Herba Commelinae 27 parts, Haematitum 18 parts, Fructus Gardeniae 18 parts, Radix Puerariae 19 parts, Radix Scutellariae 24 parts, Radix Sophorae Flavescentis 20 parts, Cortex Dictamni 25 parts, Radix et Rhizoma Thalictri 16 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 16 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 18 parts, Herba Andrographis 16 parts, the Fructus Kochiae 24 parts, Herba Houttuyniae 25 parts, Herba Violae 24 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 24 parts, Caulis Sargentodoxae 23 parts, Flos Rosae Chinensis 22 parts, Radix Gentianae Macrophyllae 14 parts, Radix Stephaniae Tetrandrae 16 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 19 parts, Caulis Trachelospermi 25 parts, geranium 16 parts, Rhizoma Dioscoreae Nipponicae 24 parts, Herba Taxilli 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 27 parts, Semen Coicis 26 parts, Semen Lepidii (Semen Descurainiae) 26 parts, 19 parts, Herba Capsellae, Rhizoma Chuanxiong 22 parts, Rhizoma Corydalis 21 parts, 25 parts, Rhizoma Curcumae Longae, Olibanum 22 parts, Myrrha 17 parts, Resina Liquidambaris 19 parts, Flos Campsis 16 parts, Caulis Spatholobi 20 parts and Herba Leonuri 15 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 20 parts, Fructus Viticis 18 parts, 24 parts, Herba Spirodelae, Radix Trichosanthis 23 parts, Herba Commelinae 26 parts, Haematitum 20 parts, Fructus Gardeniae 21 parts, Radix Puerariae 20 parts, Radix Scutellariae 18 parts, Radix Sophorae Flavescentis 22 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 22 parts, Herba Taraxaci 25 parts, Caulis Lonicerae 16 parts, Herba Andrographis 14 parts, the Fructus Kochiae 25 parts, Herba Houttuyniae 23 parts, Herba Violae 21 parts, Flos Chrysanthemi Indici 24 parts, Rhizoma Fagopyri Dibotryis 22 parts, Caulis Sargentodoxae 25 parts, Flos Rosae Chinensis 26 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 19 parts, Ramulus Mori 25 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 24 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 23 parts, Herba Taxilli 19 parts, Folium Photiniae (Folium Photiniae serrulatae) 21 parts, Semen Coicis 25 parts, Semen Lepidii (Semen Descurainiae) 25 parts, 17 parts, Herba Capsellae, Rhizoma Chuanxiong 24 parts, Rhizoma Corydalis 22 parts, 26 parts, Rhizoma Curcumae Longae, Olibanum 21 parts, Myrrha 20 parts, Resina Liquidambaris 21 parts, Flos Campsis 16 parts, Caulis Spatholobi 18 parts and Herba Leonuri 13 parts.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 3 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 500 order ~ 800 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.25 ~ 0.5 times of lactose, the starch of 0.2 ~ 0.4 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae and Radix Stephaniae Tetrandrae mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described pharmaceutical preparation oral liquid finished product.

The invention has the beneficial effects as follows: the present invention has clearing away heat and eliminating dampness, effect of clots absorbing dredging collateral, cures mainly suppurative osteomyelitis, utilizes Traditional Chinese medical theory, by regulating overall immunity, by force pointed, shorten the course of disease, treatment short treating period, feature evident in efficacy, can also play suppuration pain relieving, protect from infection, the advantage such as have no side effect.

Detailed description of the invention

The invention provides the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of a kind for the treatment of, wherein, comprise following raw medicinal material: Ramulus et Folium Tamaricis, Fructus Viticis, Herba Spirodelae, Radix Trichosanthis, Herba Commelinae, Haematitum, Fructus Gardeniae, Radix Puerariae, Radix Scutellariae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix et Rhizoma Thalictri, Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Taraxaci, Caulis Lonicerae, Herba Andrographis, the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Rhizoma Coptidis, Cortex erythrinae, Caulis Trachelospermi, geranium, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Semen Coicis, Semen Lepidii (Semen Descurainiae), Herba Capsellae, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Olibanum, Myrrha, Resina Liquidambaris, Flos Campsis, Caulis Spatholobi and Herba Leonuri.Wherein, Ramulus et Folium Tamaricis, Fructus Viticis, Herba Spirodelae, Radix Trichosanthis, Herba Commelinae, Haematitum, Fructus Gardeniae, Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Dictamni, Radix et Rhizoma Thalictri heat clearing away eliminating carbuncle, eliminating impediment; Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Taraxaci, Caulis Lonicerae, Herba Andrographis, the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae heat-clearing and toxic substances removing, pain relieving; Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Cortex erythrinae, Caulis Trachelospermi, geranium, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Semen Coicis, Semen Lepidii (Semen Descurainiae), Herba Capsellae removing dampness detumescence; Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Olibanum, Myrrha, Resina Liquidambaris, Flos Rosae Chinensis, Flos Campsis, Caulis Spatholobi, Herba Leonuri removing toxic substances are invigorated blood circulation, the effect of removing obstruction in the collateral to relieve pain.

The pharmacological property of above-mentioned each raw medicinal material is as follows:

Ramulus et Folium Tamaricis: sweet in the mouth, pungent, property are put down; Return lung meridian, stomach warp, heart channel.Essentials of Matea Medica: " control acute diseases such as cholera and sunstroke rash not go out, breathe heavily vexed unrest of coughing." function dispelling wind, induce sweat, rash, removing toxic substances.Cure mainly anemopyretic cold, measles goes out saturating from the beginning of, rash, rheumatic arthralgia, skin pruritus.Control measles thoroughly difficult, rubella itching over the body, flu, cough with asthma, rheumatic ostalgia.

Fructus Viticis: pungent, bitter, is slightly cold; Return bladder, liver, stomach warp.Shennong's Herbal: " bitter in the mouth is slightly cold.Cure mainly cold and heat between muscles and bones, arthralgia chiefly caused by damp pathogen, contracture, improving eyesight, hard Fructus Viticis tooth, sharp nine orifices, removes tapeworm." " medicine class on the analogy of natural things ": " and control Taiyang channel headache, dizzy vexed, except dizzy order is dark.The medicine of loose ailment said due to cold or exposure also.If the people of insufficiency of stomach-QI can not take, probably raw expectorant disease." dispelling wind and heat pathogens, the clear sharp head.For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.Fructus Viticis has obvious hypotensive effect, and its hypotensive effect is relevant with the parasympathetic nervous system that excited maincenter is induced.

Herba Spirodelae: pungent, cold; Enter lung, small intestine meridian.Tang Materia Medica: " duckweed person, has three kinds: large person's name Herba Marsileae Quadrifoliae; Jiang's dish is had again, also similar and leaf circle in water; The main burn of little Herba Spirodelae waterborne." " Mingyi Bielu ": " the main person of quenching one's thirst, go with damp and hot heresy, then body fluid is spontaneous, and thirsty from stopping also.It says the therapeutic method to keep the adverse QI flowing downwards, to stop bath setation originator, also with cold energy heat extraction, and testing also of removing heat from blood." diaphoresis, dispel the wind, row water, heat clearing away, removing toxic substances.Row hot carbuncle when controlling, macule is not saturating, wind heat pain rash, skin pruritus, edema, amenorrhea, and skin ulcer tinea, erysipelas, scalds.Herba Spirodelae has diuresis, and its effective ingredient is mainly potassium acetate and potassium chloride.The disease such as freely is thoroughly sent out not for affection due to external wind and heat and measles.To also oral administration, the external of wind heat urticaria.Herba Spirodelae can expel the heat-evil diuretic, therefore has exterior heat person to use it for edema.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis." book on Chinese herbal medicine justice ": " medicine so-called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, have the name of powder, real without powder.It smashes the method for thin clear powder." " book on Chinese herbal medicine is looked for the truth ": " and Radix Trichosanthis, than Fructus Trichosanthis, its property is slightly flat, seemingly do not wither impatient compel, and have push away wall fall wall merit also.There is speech regulating the spleen and stomach absolutely continuous to " warp ", say like anon-normal, but its evanescence of heat of cloud is from the meaning of peace." for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.Deficiency and coldness of spleen and stomach stool lingering diarrhea person avoids clothes.Should not with Aconitum medical material with using.Trichosanthin (Trichosanthin) is effective protein of induction of labor in midpregnancy, and it also has the activity of anti-hydatidiform mole activity and anti-AIDS (AIDS) simultaneously; Protein Karasurin has strong induced abortion effect to pregnant mouse; Protein alpha-Momorcharin and β-Momorcharin has induced labor, immunosuppressant and antitumor action.

Herba Commelinae: sweet, cold, light; Enter the heart, all warps of liver,spleen,kidney, intestine and small intestine.Supplement to the Herbal: " fourth swells, and meat disease is not smooth, infantile erysipelas, mad epilepsy of generating heat, large abdomen feeling of fullness, body face edema due to disorder of QI, and hematodiarrhoea, dog stings Serpentis, the poison such as carbuncle for main cold and heat subtertian malaria, phlegm retention." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " invigorating QI and blood is treated married woman leucorrhea, redly to be collapsed, tissue regeneration promoting blood, only hematuria, epistaxis blood, stranguria with blood." for fever caused by exogenous pathogens, or febrile disease heating is not moved back, or laryngopharynx swelling and pain, and the disease such as carbuncle skin infection.For dysuria, edema, or wet into diseases such as bet bladder, the puckery pains of dribbling urination.

Haematitum :nature and flavor: bitter sweet are flat.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be nontoxic." 3. " property of medicine opinion ": " sweet in the mouth is flat." 4. " book on Chinese herbal medicine converges and says "; " bitter and puckery flavor, temperature is nontoxic." 5. " book on Chinese herbal medicine just ": " taste is micro-sweet, cool in nature." 6. " book on Chinese herbal medicine asks former ": " acrid in the mouth and bitter, cold." return through: enter liver, stomach, heart born of the same parents warp.1. Materia Medica of Decoction: " start with few the moon, meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters burnt, the cloudy Liver Channel of fainting of few sun three." 3. " detailed outline ": " liver, envelope two are through blood system." 4. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin.5. " Changsha medicine solution ": " enter the stomach channel of foot-Yang-ming." cure mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.1. " herbal classic ": " woman is red to irrigate for main harmful wind diseases due to noxious agents produced by various parasites, abdomen poisoning pathogen.All kinds of diseases and ailments under " 2. " not Lu ": " master tape, dystocia, afterbirth does not go out, induced abortion, and nourish blood gas, and except heat in the five internal organs blood vessels, arthralgia due to stagnation of blood, blood stasis, children's adult shies gas and enters abdomen, and impotence does not rise." 3. " property of medicine opinion ": " is controlled woman's metrorrhagia and is drenched drop incessantly, treats raw son and does not fall." 4. " Japan hanako materia medica ": " emesis blood, epistaxis, hemorrhoidal hamorrhage hemorrhoid complicated by anal fistula, menstruation is more than, pediatric epilepsy scared, infantile malnutrition, regurgitation, and the de-essence of antidiarrheal dysentery, hematuria incontinence of urine, incised wound is put on flesh, antiabortive spleen invigorating, controls again many urine at night.5. " book on Chinese herbal medicine just ": " expectorant falls in the therapeutic method to keep the adverse QI flowing downwards, relieves inflammation or internal heat." 6. " Changsha medicine solution ": " drives turbid undershoot, falls the inverse gas taking the photograph lung stomach, lets out restlessness with depression except the sound of vomiting, only regurgitation vomiting, treat palpitation with fear asthma."

Fructus Gardeniae: bitter, cold, nontoxic; Enter heart channel, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Shennong's Herbal: " pathogen in main five, pathogenic heat in the stomach gas, flushed complexion wine acne vulgaris nose, the red impetigo infections of tuberculoid leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the hot swelling pain of order, the large heat of breast heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, and headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt pathogenic fire, eliminating heart-fire and relieving restlessness, the key medicine that calentura is vexed in order to control, restlessness is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels dampness-heat in the liver and gallbladder, the jaundice of available treating the liver gallbladder retention and fumigation of damp-heat inside the body, oliguria with reddish urine person.The hypotensive activity position of Fructus Gardeniae, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.

Radix Puerariae: cool in nature, sweet in the mouth, pungent, enter spleen, stomach warp.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty has carried out systematic research to Radix Puerariae, think the stem of Radix Puerariae, leaf, flower, really, root all can be used as medicine.He records like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, pungent, flat, nontoxic.

Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri is best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so house Radix Scutellariae can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section half exterior and half interior, agent is also." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae has antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus, there is certain inhibitory action, have good curative effect to upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc.

Rhizoma Coptidis: bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel." Yaoxing Fu ": " bitter in the mouth, flat, gas is trembled with fear, nontoxic.Sink also, the moon also.It is with having four: eliminating heart-fire, the shape of the epigastric fullness that disappears; Main intestinal Bleach is red except what mix in intestinal; Control order disease to break out and should use, treat skin infection head and the tail all same." function heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, and have preventing or arresting vomiting concurrently and to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, heat in blood tells nosebleed, conjunctival congestion, has a toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Radix Sophorae Flavescentis: the effect having anti-inflammation, all has inhibitory action to Propiobacterium, staphylococcus aureus, escherichia coli, can diuresis, antiallergic, ease pain, relieving asthma, eliminate the phlegm.Bitter in the mouth; Cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel; Urinary bladder channel.Effect: heat clearing and damp drying: extensive use and multiple humidifier fever, as damp-heat dysentery external can decoct soup washout, for hemorrhoid, women gynecological; Parasite killing (external), diuresis.Can heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.Compendium of Material Medica is said: " bitter cold of Radix Sophorae Flavescentis, Cortex Phellodendri, all can the kidney invigorating, and lid gets its bitter dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again.Only kidney water is weak and mutually fiery victor is suitable with it, the cold sperm if fire declines, and true strength is not enough, and year high people is also unavailable.ZHANG Cong-zheng is cloud also, all medicines all poison also, though Radix Glycyrrhizae, Radix Sophorae Flavescentis, can not poison unexpectedly, take for a long time, the five tastes respectively return it dirty, must have the trouble of victory gas increasings partially, and all medicines are all right, scholar's length when tactile class can also, as the same as diet.Again by " Records of the Historian " cloud, the sick dental caries of granary public Chunyu Yi doctor doctor Qi, moxibustion left hand yangming meridian, gargles three liters with kuh-seng soup day, careful wind of coming in and going out, and more this also got the justice that it removes the damp and hot parasite killing of pathogenic wind on five, six ".

Cortex Dictamni: bitter, salty, cold; Enter spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel." Mingyi Bielu ": " shaggy-fruited dittany.As if the raw upper valley and dried flank meat.April, May adopt root, dry in the shade." " property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow." Compendium of Material Medica: " Cortex Dictamni, gas is trembled with fear benefaction, and bitter in the mouth is dry, is various jaundice syndromes migratory arthralgia key medicine, and the skin ulcer section that the physicians from a family for generations only execute is shallow.”

Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Control damp-heat dysentery, jaundice, calentura is irritated, cough due to lung-heat, carbuncle pyogenic infections from tumour or sore, conjunctival congestion and swelling pain.Be applied to enteritis now, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.Fetidine has hypotensive effect, and its crude preparation by using can control hypertension.Magnoflorine, berberine, jateorhizine etc. are see Radix Aristolochiae, Rhizoma Coptidis bar.Congener Radix thalictri petaloidei Thalictrumpetaloideum or T.simplex T.simplex is containing thalcimine (Thalsimine), have antiinflammatory, analgesia, cooling effect to animal. purple meadowrue (Thalictrum dasycarpum) T.Dasycarpum containing Thalictrum aquilegifolium L. var. sibiricum Regel card product alkali (Thalicarpine), purple meadowrue (Thalictrum dasycarpum) alkali (Thalidasine), thalfetidine, to rat watt g cancer 1 and Mice Bearing Lewis Lung Cancer effective.Thalictrum aquilegifolium L. var. sibiricum Regel card product alkali also has weak hypotensive effect.

Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.

Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down, poisonous; Return liver, stomach, kidney, spleen channel." supplement to the Herbal: " careless Limonitum, root such as small cup joins together, and half on soil, and skin is as Poria, and the red puckery of meat, people gets Yi Danggu, not hungry." Compendium of Material Medica: " Rhizoma Smilacis Glabrae has red white two kinds, enters medicinal Bai Zheliang.Removing toxic substances, dehumidifying, sharp joint.Cure mainly syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treat furuncle, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.

Herba Taraxaci: nature and flavor: sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp." Bencao Jingshu ": " Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " apply all pyogenic infections from tumour or sore, the ruined tinea skin ulcer of scabies; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Can be used for upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.

Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral, cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the cards such as redness and swelling of joints burning pain.

Herba Andrographis: have heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.Ear drop topical application be can be made into suppurative otitis media, simultaneously Tabellae Andrographitis for oral administration.

The Fructus Kochiae: cold in nature, acrid in the mouth, hardship; Enter kidney, urinary bladder channel." property of medicine opinion ": " with Actinolitum with taking, main husband's impotence does not rise, QI invigorating benefit power; Control cloudy ovum Huang disease, reduce phlegm and internal heat wind, can make soup and take a shower." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sharp bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear sharp fetal heat in pregnancy, damp-heat vaginal discharge." clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, these product have the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.

Herba Violae: bitter in the mouth, pungent, cold in nature, enters the heart, Liver Channel, has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, main influenza; Upper respiratory tract infection; Tonsillitis; Infectious hepatitis; Intestinal is scorching; Dysentery; Nephritis; Parotitis; Conjunctivitis; Acute appendicitis; Furuncle carbuncle; Scrofula.Heat-clearing and toxic substances removing.Control furuncle carbuncle, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": removing blood stasis, carbuncle mange is separated, nine kinds of hemorrhoid, all sore diseases.2. " detailed outline ": cure mainly all carbuncle carbuncle on the back, furuncle swells scrofula, innominate toxic swelling, malignant boil.3. " book on Chinese herbal medicine asks former ": removing heat from blood, detumescence poison.Control heat in blood flaccidity due to malnutrition of tendons, deposited skin ulcer is wonderful.4. " south of the Five Ridges gather medicinal herbs record ": make cathartic and tell medicine.5. " Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, externally applied toxicity removing detumescence.Control conjunctival congestion and swelling pain, hordeolum, treat pyogenic infections from tumour or sore, acute mastitis, enteritis, diarrhea, venom.6. revive doctor's " Chinese herbal medicine handbook ": control all pyogenic infections, venom, lymphoid tuberculosis, jaundice, nephritis, cystitis, arthralgia, have blood in stool, epistaxis, eye conjunctivitis, prostatitis.Herba Violae has inhibitory action in various degree to Staphyloccocus aureus, pneumobacillus, escherichia coli, alpha streptococcus, group B streptococcus, hemophilus influenza, diphtheria corynebacterium, bacillus pyocyaneus, white grapes sugar coccus, Candida albicans.

Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent." book on Chinese herbal medicine converges and says ": " removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.As heat-clearing and toxic substances removing, according to Nantong experience, must take by stewing out of water juice, decoction then curative effect is not remarkable.Clinical in controlling laryngopharynx swelling and pain.

Caulis Sargentodoxae: bitter in the mouth, property is put down, and returns liver, large intestine channel, " Hunan medicine will ": " stimulate the menstrual flow and enrich blood, bone and muscle strengthening, anthelmintic.Control traumatic injury, rheumatalgia, bruise, stranguria with blood, bones and muscles pain, furuncle, filaricide." " simple and easy medical herbs ": " control bones and muscles pain, chase after wind, strong waist knee joint, tonifying YANG thing." there is the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cure mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.

Radix Gentianae Macrophyllae: pungent, bitter, is slightly cold.Return stomach warp, Liver Channel, gallbladder meridian." Mingyi Bielu ": " Radix Gentianae Macrophyllae can treat wind, and new for a long time without asking, the whole body contraction is anxious ".Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.Rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached.Its property is partially cold, has heat clearing away effect concurrently, therefore particularly suitable to pyretic arthralgia, also can be used for apoplexy and hemiplegia, deviation of the eye and mouth, spasm of the limbs, aphasia with stiff tongue etc., and alone being decocted in water for oral dose in a large number can be proved effective.Gentianin obviously can alleviate the asthma and tic that Cavia porcellus causes because of histamine spray; Also significant protective effect is had to the Ovum Gallus domesticus album anaphylactic shock of rabbit.The intestinal contraction that gentianin energy antagonizing histamine and acetylcholine cause, especially with stronger to the former antagonism.

Radix Stephaniae Tetrandrae: nature and flavor: bitter, cold." property of medicine opinion " is said: " Radix Stephaniae Tetrandrae: bitter in the mouth.Enter bladder, spleen, kidney channel.Effect: inducing diuresis to remove edema, wind-expelling pain-stopping.Cure mainly: edema beriberi, dysuria, eczema sore, rheumatic arthralgia, vascular hypertension.It is generally acknowledged, the effect of Radix Stephaniae Tetrandrae inducing diuresis to remove edema is comparatively strong, and the effect of Radix cocculi laurifolii wind-expelling pain-stopping is better.Containing multiple alkaloid, be mainly sinomenine, demethyl sinomenine.Pharmacology: the effect having analgesia, antipyretic, antiinflammatory, of flaccid muscles, diuresis, antianaphylaxis shock and reduce blood pressure.

Ramulus Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.Containing trypsininhibitory substance in Fructus Mori, cause the digestive enzyme in intestinal can not destroy C type and produce bacillus capsulatus B toxin, and causing bleeding property enteritis.Fructus Mori fatty acids, excessive eating can produce irritation to digestive tract.

Cortex erythrinae: toil is flat.Enter liver, spleen channel." Kaibao Bencao ": " main cholera attacked by pestiferous factors, red white chronic dysentery, except sweetly hideing, scabies.Tooth worm pain, and boil clothes and contain it, order is washed in water logging, except skin is red." " Haiyao Bencao, Oversea Materia Medica ": " main waist foot is unsuccessful, insensitive impediment lower limb knee joint pain, cholera, red white dysentery, dysentery, scabies." wind-damp dispelling, the meridian dredging, parasite killing.Dispelling the wind and dampness pathogens arthralgia pain, dysentery, toothache, scabies.

Caulis Trachelospermi: bitter, is slightly cold.GUIXIN, liver, kidney channel." herbal classic ": " carbuncle does not disappear, and mouthpiece swells for the dead flesh carbuncle wound of main air heat, xerostomia scorching tongue, water slurry not under." Tang Materia Medica: " treat blood agglomeration in puerperal.Agkistrodon halys skin ulcer, strand extracting juice washes it, takes juice and also goes the snake venom heart vexed; The all skin ulcers of injury by sword or axe, Feng Zhi." there is expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.The dull and stereotyped trench method of this product 50% decoct, has inhibitory action to staphylococcus aureus, shigella flexneri and Bacillus typhi.Arctigenin can stimulate cold-blooded and homoiothermic animal central nervous system, and make accelerated breathing, heavy dose causes respiratory failure, more weak to key role, can cause vasodilation, blood pressure drops, and make mouse skin rubescent, diarrhoea.In addition but inhibitory action is had to isolated rabbit intestinal and uterus.

Geranium: bitter, micro-pungent is flat.Return liver, kidney, large intestine channel." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control meridian hectic fever, dizzy, be afraid of cold, limbs are aching and tired, poor appetite, the virgin infantile malnutrition of male geranium woman, deficient fever do not move back person with it, diuresis, buffalo meat is for drawing." remove rheumatism, for rheumatic arthralgia.The extract of the wild geranium root of geranium contains flavonoid, catechin, tannin, and wherein the effect of resisiting influenza virus is the most obvious to suppress copy (as influenza, herpes simplex, cowpox, the HIV-I) of multiple virus.Geranium can suppress liver mitochondrion and MC lipid peroxidation, reduces plasma cholesterol and GOT/GPT level, suppresses the mitochondrial lipid peroxidation effect brought out by ADP and ascorbic acid.The sterile water solution of geranium extract all has inhibitory action to shigella flexneri, escherichia coli, staphylococcus aureus, bacillus pyocyaneus in vitro.

Rhizoma Dioscoreae Nipponicae: property is flat, bitter in the mouth." Shaanxi Chinese herbal medicine ": " control cough, rheumatic arthritis, Kaschin-Beck disease arthralgia, dyspepsia, malaria, traumatic injury, carbuncle malignant boil." have relaxing muscles and tendons to promote blood circulation, the diuretic that helps digestion, preventing the attack (or recurrence) of malaria function of eliminating the phlegm.Be usually used in anemofrigid-damp arthralgia in the past, chronic tracheitis, dyspepsia, strain sprained, the treatment of the disease such as malaria, carbuncle.Now being used for extracting dioscin, is synthesis cortin of succenturiate kidney and oral and primary raw material that is injection contraceptive.

Herba Taxilli: bitter, sweet, property is put down.Enter liver, kidney channel." not Lu ": " main incised wound, goes numbness, woman's metrorrhagia, and internal injury is not enough, disease more than puerperal, lower milk." " the SHENGCAO property of medicine is standby to be wanted ": " disappear heat, and nourishing, chases after wind.To nourish blood heat radiation, make tea-drinking, relaxing muscles and tendons and activating QI and blood in the collateral." can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Main soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.

Folium Photiniae (Folium Photiniae serrulatae): pungent is bitter, flat.Shennong's Herbal: " support kidney qi, interior impairment of YIN declines, relieving rigidity of muscles and joints fur." " Mingyi Bielu ": " treat flaccidity of the lower limbs, the five internal organs pathogen, heat extraction." function cures mainly and dispel the wind, dredging collateral, kidney tonifying.For pathogenic wind-warm arthralgia pain, aching pain in waist and back, the foot and knee being feeble, migraine.Ursolic acid contained by Chinese photinia has significantly stable and cooling effect, and has analgesia, antiinflammatory and antitumaous effect, has inhibitory action to gram positive bacteria, negative bacterium and yeast; Decoct has excitation to the frog heart; Alcohol leaching liquid can suppress the frog heart, shrinks rabbit ear blood vessel, reduces dog blood pressure.

Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, there is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea, Semen Coicis can be used as medicine, and is used for treating edema, beriberi, diarrhea due to hypofunction of the spleen etc.Make skin smooth, reduce wrinkle, eliminate effect of pigment spot.Have obvious curative effect to face acne and pachylosis, in addition, it also has absorbability to ultraviolet, and its extractive matter adds in cosmetics also can reach sun-proof and effect that is anti-ultraviolet.Be suitable for various cancer patient, arthritis, acute and chronic nephritis edema, cancer ascites, puffiness of the face and limbs, vitamin B1 deficiency edema person, warty vegetation, beauty treatment person, juvenile verruca plana, common wart, molluscum contagiosum, young acne pimple and the coarse person of other skin malnutrition, be suitable for consumptive lung disease, lung abscess person eats.

Semen Lepidii (Semen Descurainiae): nature and flavor: arduous, cold.1. " herbal classic ": " acrid in the mouth, cold." 2. " not Lu ": " be bitter, Great Cold, nontoxic." return through: enter lung, urinary bladder channel.1. " Thunder God concocts property of medicine solution ": " lung, the heart, spleen, bladder four warp." 2. " Bencao Jingshu ": " is the positive medicine of meridian of Hand-TAI YIN, and sun of also starting with is bright, meridian of Foot-TAI YANG." 3. " book on Chinese herbal medicine is looked for the truth ": " enters lung, double enter stomach." 4. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." cure mainly: therapeutic method to keep the adverse QI flowing downwards row water.Control lung and stop up dyspnea with rapid respiration, expectorant bank is coughed, edema distension.1. " herbal classic ": " main lump in the abdomen stagnation of QI, diet cold and heat, broken hard by heresy, tonneau water channel." 2. " not Lu ": " lower bladder water, volt stays steam, between skin evil waterborne go out, the edema of the face, the sudden and violent apoplexy miliaria alba of body is itched, sharp lower abdomen." 3. " property of medicine is fallen ": " diuresis, takes out urgency that lung qi pants, antitussive." 4. " Kaibao Bencao ": " treatment lung stops up upper gas cough, and Dingchuan is urged, and removes phlegm retention in the heart." 5. " typhoid fever class is wanted ": " controls kidney illness, dry lip." 6. " detailed outline ": " leads to menstruation."

Herba Capsellae: be slightly cold is sweet, light.Energy cooling blood for hemostasis, promoting urination to remove dampness, liver heat removing and eyesight improving.Medicine Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, heart channel.Shennong's Herbal: " main apoplexy enters brain headache, arthralgia due to cold, and muscle moderate pulse is anxious, and incised wound, married woman's blood closes loss of fecundity." " Japan hanako materia medica ": " control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken crux stagnated blood, supports fresh blood, put on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood." gas perfume rises loose.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.Cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia is suffered from abdominal pain, lump, heart pain in chest and hypochondrium, and traumatic injury swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores.For headache due to common cold, the diseases such as migraine and general headache.The pungent perfume (or spice) of Rhizoma Chuanxiong is kind to be risen, and can push up on up head mountain peak, has wind-expelling pain-stopping effect, for controlling wind syndrome of head headache key medicine.In addition, clinical conventional these product treatment angina pectoris.The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves the blood oxygen supply of cardiac muscle, and reduces the oxygen consumption of cardiac muscle; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can surface activity of blood platelet be reduced, suppress platelet aggregation, the formation of pre-preventing thrombosis.

Rhizoma Corydalis: invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.The all pains of main trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.1, analgesic activity: Rhizoma Corydalis powder has analgesic activity, its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, B prime, Chou prime, Kui prime all have analgesic activity, stronger with B prime. various dosage form with alcohol extractum and powder effect strong.2, calm, stable, syngignoscism: tetrahydropalmatine has certain calmness, stable effect, and its levo form is novel central inhibitor, has obvious syngignoscism during larger dose to rabbit, Canis familiaris L., monkey.3, on the impact of digestive system: dehydrogenation Corydaline has significant anti-Experimental Gastric Ulcer in Rats effect.4, to cardiovascular effect: tetrahydropalmatine, Chou prime have slight blood pressure lowering, decreased heart rate effect; Dehydrocory daline has blood pressure lowering, increases CBSF effect, the rat heart muscle necrosis effect that ethanol extract also has coronary artery dilating, antagonism isoproterenol causes.

Rhizoma Curcumae Longae: acrid in the mouth, hardship, warm in nature, return liver, spleen channel, Compendium of Material Medica: " Rhizoma Curcumae Longae, time near with flat if Rhizoma Zingiberis shape person is for RHIZOMA WENYUJIN CONCISA, circle such as Cicadae abdomen shape person be Cicadae tripe Radix Curcumae, though and the ， Shu shape seemingly Radix Curcumae of dyeing that can soak, complexion is not yellow yet." " book on Chinese herbal medicine asks former ": " and Rhizoma Curcumae Longae, benefit fire is angry, this cremate gas of pungent temperature, and gas biochemistry then body fluid is capable of three YIN and three YANG; Clear person notes in lung, turbid person note in through, slip in sea, and blood is voluntarily, is the eliminating stagnation and doublely let out blood also of regulating the flow of vital energy." there is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.For amenorrhea due to stagnation of blood, menalgia, the breast side of body twinges, rheumatic arthralgia, shoulder arm pain, the cards such as injury from falling down.

Olibanum: arduous, temperature.Enter the heart, liver, spleen channel.Supplement to the Herbal: " treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes." Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Headed by Olibanum, the uterus ball of taste medicine antibacterially have stronger bacteriostasis than multiple, and effectively can kill infusorian.Therefore all pain of all heart stomach flank limbs joints all can control it.Be apt to again control woman's dysmenorrhea, postnatal blood stasis is had a pain, irregular menstrual cycle.Power that its ventilation is invigorated blood circulation, be apt to control anemofrigid-damp arthralgia again, the whole body is numb, and extremity are unsuccessful and all skin infection are swollen aches, or its skin ulcer is not ached firmly.External be powder with deposited skin infection, can detoxify, detumescence, granulation promoting, to relieve the pain, though the product for opening, unlikely wasting QI-blood, sincere good medicine is also.

Myrrha: acrid in the mouth, hardship, property is put down, and GUIXIN, liver, spleen channel, have dissipating blood stasis analgesic therapy, and effect of detumescence and promoting granulation, cures mainly obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, rheumatic arthralgia, traumatic injury, the cards such as carbuncle skin infection.The water logging agent (1:2) of Myrrha in vitro to trichophyton, Trichophyton concentricunm, permitted the multiple pathogenic dermatophytess such as blue achorion and had inhibitory action in various degree.Its antibacterial action may be relevant with contained eugenol.Oleo-resins part, to the male rabbit hypercholesterolemia of raising hydrogenated vegetable oil and causing, has the effect reducing cholesterolemia content, and can prevent Mottling formation.

Resina Liquidambaris: pungent is bitter, flat; Return spleen, lung, Liver Channel.Function expelling wind and activating blood circulation, removing toxic substances pain relieving, hemostasia and promoting granulation.For carbuncle, skin ulcer rash, scrofula, toothache, arthralgia pain, paralysis, spits blood, epistaxis, spitting of blood, traumatic hemorrhage, chapped skin.Resina Liquidambaris and volatile oil experiment in vitro thereof can make Sanguis Leporis seu oryctolagi bolt contraction in length and weight (weight in wet base and dry weight) alleviate, and experiments in vivo display can obviously suppress rat suppository to be formed; Test tube method experiment shows to significantly improve plasmin activity, significantly improves cAMP content in platelet.Show Resina Liquidambaris and volatile oil anti thrombotic action thereof and promotion fibrinolytic and improve platelet cAMP relevant, and point out volatile oil may be the main hemostatic compositions of Resina Liquidambaris.

Flos Rosae Chinensis: Flos Rosae Chinensis is not only the gorgeous ornamental flower of florescence long, fragrant color, and be gynecological's good medicine simply.The traditional Chinese medical science is thought, Chinese rose sweet in the mouth, warm in nature, enters Liver Channel, has effect of promoting blood flow to regulate menstruation, subduing swelling and detoxicating.Because the blood stasis dispelling of Flos Rosae Chinensis, circulation of qi promoting, analgesic effect are obvious, therefore be often used to the stasis for the treatment of stagnation of liver-QI, menoxenia, dysmenorrhea, amenorrhea and distending pain in the chest and hypochondrium.Traumatic injury, pain caused by ecchymoma, swollen ulcer drug, scrofula.

Flos Campsis: sweet, sour, cold; Return liver, pericardium channel.Compendium of Material Medica: " stem and leaf band is bitter, and promoting the circulation of blood divides, the fire second of the three ten-day periods of the hot season of dehematizing for Ling Leihua and root, sweet acid and trembling with fear, therefore the card of the main product breast all diseases of metrorrhagia and blood hot air wind producing also." " herbal classic is met former ": " and Ling Xuehua, metopodynia blood closes, pricking caused by the stagnation of QI and blood, strict wind malignant boil multiplex it, all get the merit of its dispelling malignant blood also." Shennong's Herbal: " lump in the abdomen, blood closes, cold and heat weakness and emaciation for disease more than housewife people's galactopoiesis, metrorrhagia." promoting the circulation of blood blood stasis removing, cooling blood, expelling wind.For Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.

Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.Pharmacological action: to the effect of hemopoietic system; To the effect of blood coagulation, fibrinolytic; Suppress heart and the effect of reducing blood pressure; Antitumaous effect; To the adjustment of lipid metabolism.

Herba Leonuri: bitter in the mouth, pungent, cold nature, enters liver, pericardium channel, Tang Materia Medica: " apply fourth to swell, take juice and make fourth toxic swelling internal diabetes; Descend dead fetus in the uterus again, feeling of distension and oppression after main product; All assorted poison swell, and red trip etc. are swollen; Extracting juice such as bean drips in ear, main Ting ear; Middle a poisonous snake mentioned in ancient books snake venom, applies it." there is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing, for the menoxenia caused by blood stasis, dysmenorrhea, amenorrhea, puerperal abdonimal pain or lochiorrhea, edema, dysuria, traumatic injury, the cards such as sore and toxic.Effective ingredient is Herba Leonuri element (Leonurin), take orally and can distend the blood vessels and make blood pressure drops, and have the adrenolytic effect of a word used in person's names, arteriosclerotic and neuropathic hypertension can be controlled, the frequency of uterus movement can be increased again, for puerperal promotes uterotonic, and cause effectively languisher to long-term metrorrhagia, leonurine solution has curariform action mask to frog neuromuscular specimen; There is diuresis to anesthetized rabbit intravenous injection, during high concentration, can haemolysis be caused. Herba Leonuri has remarkable therapeutic effect to the acute renal failure of Canis familiaris L. ischemic-type initial phase.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 10 ~ 25 parts, Fructus Viticis 12 ~ 24 parts, 15 ~ 30 parts, Herba Spirodelae, Radix Trichosanthis 16 ~ 32 parts, Herba Commelinae 18 ~ 35 parts, Haematitum 10 ~ 30 parts, Fructus Gardeniae 14 ~ 26 parts, Radix Puerariae 11 ~ 24 parts, Radix Scutellariae 12 ~ 30 parts, Radix Sophorae Flavescentis 12 ~ 25 parts, Cortex Dictamni 18 ~ 32 parts, Radix et Rhizoma Thalictri 10 ~ 24 parts, Flos Lonicerae 13 ~ 31 parts, Rhizoma Smilacis Glabrae 10 ~ 25 parts, Herba Taraxaci 18 ~ 30 parts, Caulis Lonicerae 10 ~ 22 parts, Herba Andrographis 8 ~ 21 parts, the Fructus Kochiae 14 ~ 32 parts, Herba Houttuyniae 17 ~ 34 parts, Herba Violae 15 ~ 28 parts, Flos Chrysanthemi Indici 13 ~ 33 parts, Rhizoma Fagopyri Dibotryis 11 ~ 30 parts, Caulis Sargentodoxae 18 ~ 32 parts, Flos Rosae Chinensis 16 ~ 30 parts, Radix Gentianae Macrophyllae 9 ~ 23 parts, Radix Stephaniae Tetrandrae 10 ~ 24 parts, Ramulus Mori 13 ~ 31 parts, Rhizoma Coptidis 18 ~ 30 parts, Cortex erythrinae 12 ~ 24 parts, Caulis Trachelospermi 11 ~ 30 parts, geranium 8 ~ 21 parts, Rhizoma Dioscoreae Nipponicae 13 ~ 30 parts, Herba Taxilli 12 ~ 23 parts, Folium Photiniae (Folium Photiniae serrulatae) 16 ~ 32 parts, Semen Coicis 19 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 17 ~ 35 parts, 12 ~ 24 parts, Herba Capsellae, Rhizoma Chuanxiong 17 ~ 31 parts, Rhizoma Corydalis 13 ~ 27 parts, 19 ~ 30 parts, Rhizoma Curcumae Longae, Olibanum 14 ~ 25 parts, Myrrha 13 ~ 24 parts, Resina Liquidambaris 14 ~ 26 parts, Flos Campsis 11 ~ 24 parts, Caulis Spatholobi 13 ~ 26 parts and Herba Leonuri 10 ~ 20 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 12 ~ 23 parts, Fructus Viticis 15 ~ 22 parts, 18 ~ 26 parts, Herba Spirodelae, Radix Trichosanthis 19 ~ 30 parts, Herba Commelinae 20 ~ 33 parts, Haematitum 10 ~ 22 parts, Fructus Gardeniae 16 ~ 24 parts, Radix Puerariae 15 ~ 23 parts, Radix Scutellariae 14 ~ 28 parts, Radix Sophorae Flavescentis 16 ~ 24 parts, Cortex Dictamni 19 ~ 30 parts, Radix et Rhizoma Thalictri 12 ~ 22 parts, Flos Lonicerae 15 ~ 27 parts, Rhizoma Smilacis Glabrae 13 ~ 24 parts, Herba Taraxaci 20 ~ 28 parts, Caulis Lonicerae 14 ~ 20 parts, Herba Andrographis 9 ~ 20 parts, the Fructus Kochiae 18 ~ 30 parts, Herba Houttuyniae 19 ~ 32 parts, Herba Violae 16 ~ 25 parts, Flos Chrysanthemi Indici 14 ~ 30 parts, Rhizoma Fagopyri Dibotryis 15 ~ 28 parts, Caulis Sargentodoxae 18 ~ 28 parts, Flos Rosae Chinensis 18 ~ 28 parts, Radix Gentianae Macrophyllae 10 ~ 22 parts, Radix Stephaniae Tetrandrae 12 ~ 20 parts, Ramulus Mori 14 ~ 30 parts, Rhizoma Coptidis 20 ~ 28 parts, Cortex erythrinae 14 ~ 22 parts, Caulis Trachelospermi 13 ~ 27 parts, geranium 9 ~ 20 parts, Rhizoma Dioscoreae Nipponicae 15 ~ 28 parts, Herba Taxilli 15 ~ 20 parts, Folium Photiniae (Folium Photiniae serrulatae) 18 ~ 30 parts, Semen Coicis 20 ~ 28 parts, Semen Lepidii (Semen Descurainiae) 20 ~ 30 parts, 15 ~ 22 parts, Herba Capsellae, Rhizoma Chuanxiong 18 ~ 30 parts, Rhizoma Corydalis 15 ~ 24 parts, 20 ~ 28 parts, Rhizoma Curcumae Longae, Olibanum 15 ~ 24 parts, Myrrha 14 ~ 22 parts, Resina Liquidambaris 15 ~ 25 parts, Flos Campsis 13 ~ 22 parts, Caulis Spatholobi 14 ~ 24 parts and Herba Leonuri 12 ~ 18 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 16 parts, Fructus Viticis 14 parts, 26 parts, Herba Spirodelae, Radix Trichosanthis 28 parts, Herba Commelinae 25 parts, Haematitum 14 parts, Fructus Gardeniae 16 parts, Radix Puerariae 18 parts, Radix Scutellariae 22 parts, Radix Sophorae Flavescentis 24 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 25 parts, Rhizoma Smilacis Glabrae 19 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 20 parts, Herba Andrographis 18 parts, the Fructus Kochiae 17 parts, Herba Houttuyniae 24 parts, Herba Violae 22 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 26 parts, Caulis Sargentodoxae 22 parts, Flos Rosae Chinensis 25 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 21 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 27 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 18 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 25 parts, Herba Taxilli 15 parts, Folium Photiniae (Folium Photiniae serrulatae) 26 parts, Semen Coicis 24 parts, Semen Lepidii (Semen Descurainiae) 22 parts, 20 parts, Herba Capsellae, Rhizoma Chuanxiong 19 parts, Rhizoma Corydalis 25 parts, 28 parts, Rhizoma Curcumae Longae, Olibanum 20 parts, Myrrha 18 parts, Resina Liquidambaris 24 parts, Flos Campsis 16 parts, Caulis Spatholobi 24 parts and Herba Leonuri 15 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 17 parts, Fructus Viticis 19 parts, 22 parts, Herba Spirodelae, Radix Trichosanthis 25 parts, Herba Commelinae 27 parts, Haematitum 18 parts, Fructus Gardeniae 18 parts, Radix Puerariae 19 parts, Radix Scutellariae 24 parts, Radix Sophorae Flavescentis 20 parts, Cortex Dictamni 25 parts, Radix et Rhizoma Thalictri 16 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 16 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 18 parts, Herba Andrographis 16 parts, the Fructus Kochiae 24 parts, Herba Houttuyniae 25 parts, Herba Violae 24 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 24 parts, Caulis Sargentodoxae 23 parts, Flos Rosae Chinensis 22 parts, Radix Gentianae Macrophyllae 14 parts, Radix Stephaniae Tetrandrae 16 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 19 parts, Caulis Trachelospermi 25 parts, geranium 16 parts, Rhizoma Dioscoreae Nipponicae 24 parts, Herba Taxilli 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 27 parts, Semen Coicis 26 parts, Semen Lepidii (Semen Descurainiae) 26 parts, 19 parts, Herba Capsellae, Rhizoma Chuanxiong 22 parts, Rhizoma Corydalis 21 parts, 25 parts, Rhizoma Curcumae Longae, Olibanum 22 parts, Myrrha 17 parts, Resina Liquidambaris 19 parts, Flos Campsis 16 parts, Caulis Spatholobi 20 parts and Herba Leonuri 15 parts.

Wherein, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 20 parts, Fructus Viticis 18 parts, 24 parts, Herba Spirodelae, Radix Trichosanthis 23 parts, Herba Commelinae 26 parts, Haematitum 20 parts, Fructus Gardeniae 21 parts, Radix Puerariae 20 parts, Radix Scutellariae 18 parts, Radix Sophorae Flavescentis 22 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 22 parts, Herba Taraxaci 25 parts, Caulis Lonicerae 16 parts, Herba Andrographis 14 parts, the Fructus Kochiae 25 parts, Herba Houttuyniae 23 parts, Herba Violae 21 parts, Flos Chrysanthemi Indici 24 parts, Rhizoma Fagopyri Dibotryis 22 parts, Caulis Sargentodoxae 25 parts, Flos Rosae Chinensis 26 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 19 parts, Ramulus Mori 25 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 24 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 23 parts, Herba Taxilli 19 parts, Folium Photiniae (Folium Photiniae serrulatae) 21 parts, Semen Coicis 25 parts, Semen Lepidii (Semen Descurainiae) 25 parts, 17 parts, Herba Capsellae, Rhizoma Chuanxiong 24 parts, Rhizoma Corydalis 22 parts, 26 parts, Rhizoma Curcumae Longae, Olibanum 21 parts, Myrrha 20 parts, Resina Liquidambaris 21 parts, Flos Campsis 16 parts, Caulis Spatholobi 18 parts and Herba Leonuri 13 parts.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 3 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 500 order ~ 800 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.25 ~ 0.5 times of lactose, the starch of 0.2 ~ 0.4 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Wherein, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae and Radix Stephaniae Tetrandrae mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described pharmaceutical preparation oral liquid finished product.

Embodiment 1 tablet

The manufacturing process of oral tablet of the present invention is: get Ramulus et Folium Tamaricis 160g, Fructus Viticis 140g, Herba Spirodelae 260g, Radix Trichosanthis 280g, Herba Commelinae 250g, Haematitum 140g, Fructus Gardeniae 160g, Radix Puerariae 180g, Radix Scutellariae 220g, Radix Sophorae Flavescentis 240g, Cortex Dictamni 260g, Radix et Rhizoma Thalictri 170g, Flos Lonicerae 250g, Rhizoma Smilacis Glabrae 190g, Herba Taraxaci 260g, Caulis Lonicerae 200g, Herba Andrographis 180g, Fructus Kochiae 170g, Herba Houttuyniae 240g, Herba Violae 220g, Flos Chrysanthemi Indici 180g, Rhizoma Fagopyri Dibotryis 260g, Caulis Sargentodoxae 220g, Flos Rosae Chinensis 250g, Radix Gentianae Macrophyllae 200g, Radix Stephaniae Tetrandrae 210g, Ramulus Mori 180g, Rhizoma Coptidis 270g, Cortex erythrinae 200g, Caulis Trachelospermi 180g, geranium 140g, Rhizoma Dioscoreae Nipponicae 250g, Herba Taxilli 150g, Folium Photiniae (Folium Photiniae serrulatae) 260g, Semen Coicis 240g, Semen Lepidii (Semen Descurainiae) 220g, Herba Capsellae 200g, Rhizoma Chuanxiong 190g, Rhizoma Corydalis 250g, Rhizoma Curcumae Longae 280g, Olibanum 200g, Myrrha 180g, Resina Liquidambaris 240g, Flos Campsis 160g, Caulis Spatholobi 240g and Herba Leonuri 150g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 80%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 700 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.3 times of lactose, the starch of 0.4 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.035 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 capsule

The manufacturing process of the capsule that the present invention is oral is: get Ramulus et Folium Tamaricis 170g, Fructus Viticis 190g, Herba Spirodelae 220g, Radix Trichosanthis 250g, Herba Commelinae 270g, Haematitum 180g, Fructus Gardeniae 180g, Radix Puerariae 190g, Radix Scutellariae 240g, Radix Sophorae Flavescentis 200g, Cortex Dictamni 250g, Radix et Rhizoma Thalictri 160g, Flos Lonicerae 240g, Rhizoma Smilacis Glabrae 160g, Herba Taraxaci 260g, Caulis Lonicerae 180g, Herba Andrographis 160g, Fructus Kochiae 240g, Herba Houttuyniae 250g, Herba Violae 240g, Flos Chrysanthemi Indici 180g, Rhizoma Fagopyri Dibotryis 240g, Caulis Sargentodoxae 230g, Flos Rosae Chinensis 220g, Radix Gentianae Macrophyllae 140g, Radix Stephaniae Tetrandrae 160g, Ramulus Mori 180g, Rhizoma Coptidis 240g, Cortex erythrinae 190g, Caulis Trachelospermi 250g, geranium 160g, Rhizoma Dioscoreae Nipponicae 240g, Herba Taxilli 180g, Folium Photiniae (Folium Photiniae serrulatae) 270g, Semen Coicis 260g, Semen Lepidii (Semen Descurainiae) 260g, Herba Capsellae 190g, Rhizoma Chuanxiong 220g, Rhizoma Corydalis 210g, Rhizoma Curcumae Longae 250g, Olibanum 220g, Myrrha 170g, Resina Liquidambaris 190g, Flos Campsis 160g, Caulis Spatholobi 200g and Herba Leonuri 150g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.4:0.2, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 3 oral liquid

The manufacturing process of the oral liquid that the present invention is oral is: get Ramulus et Folium Tamaricis 200g, Fructus Viticis 180g, Herba Spirodelae 240g, Radix Trichosanthis 230g, Herba Commelinae 260g, Haematitum 200g, Fructus Gardeniae 210g, Radix Puerariae 200g, Radix Scutellariae 180g, Radix Sophorae Flavescentis 220g, Cortex Dictamni 260g, Radix et Rhizoma Thalictri 170g, Flos Lonicerae 240g, Rhizoma Smilacis Glabrae 220g, Herba Taraxaci 250g, Caulis Lonicerae 160g, Herba Andrographis 140g, Fructus Kochiae 250g, Herba Houttuyniae 230g, Herba Violae 210g, Flos Chrysanthemi Indici 240g, Rhizoma Fagopyri Dibotryis 220g, Caulis Sargentodoxae 250g, Flos Rosae Chinensis 260g, Radix Gentianae Macrophyllae 200g, Radix Stephaniae Tetrandrae 190g, Ramulus Mori 250g, Rhizoma Coptidis 240g, Cortex erythrinae 200g, Caulis Trachelospermi 240g, geranium 140g, Rhizoma Dioscoreae Nipponicae 230g, Herba Taxilli 190g, Folium Photiniae (Folium Photiniae serrulatae) 210g, Semen Coicis 250g, Semen Lepidii (Semen Descurainiae) 250g, Herba Capsellae 170g, Rhizoma Chuanxiong 240g, Rhizoma Corydalis 220g, Rhizoma Curcumae Longae 260g, Olibanum 210g, Myrrha 200g, Resina Liquidambaris 210g, Flos Campsis 160g, Caulis Spatholobi 180g and Herba Leonuri 130g,

The first step, by the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae and Radix Stephaniae Tetrandrae mixing, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 3 times, each 4 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.38, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times of water gagings, boils 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.35;

3rd step, the described mastic mixing that the first step, second step are obtained, 80 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 75%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 48 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 80 minutes, and temperature is 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described pharmaceutical preparation oral liquid finished product.

Acute toxicity testing:

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch my Out-patient Department of source or in-patient department year February in March, 2010 to the 2012 228 routine damp and hot heresy stagnant type suppurative osteomyelitis patient through pathology or clinical confirmation, male 132 example, women 96 example, 7 ~ 45 years old age, 17 years old mean age.The course of disease 14 days ~ 3 years, Hematogenous infection 9 example, previously trauma history person 24 example, person 18 is routine to specify postoperative infection, without clear and definite reason person 15 example; Femur morbidity 17 example, tibia morbidity 26 example, humerus morbidity 13 example, hands, sufficient bone morbidity 14 example; Wherein there is small pieces sequestrum person 19 example, dead space 25 example, abscess 22 example, sinus tract sepage 26 example.All cases is divided into treatment group and matched group at random, and treatment group comprises each 57 examples of tablet in treatment group, capsule treatment group and oral liquid treatment group, and matched group is 57 examples.Above-mentioned patient age, sex, the course of disease etc. are through statistical procedures, and difference there are no significant meaning (P ﹥ 0.05), has comparability.

Diagnostic criteria:

1. premorbid has skin wound, furuncle, angina, open fracture.

2. onset is anxious, can have high heat, shiver with cold, general malaise, even delirium, tic etc.

3. suffering limb severe pain, dare not be movable, and affected part has dark tenderness.During egilops periosteum, severe pain alleviates, with local swelling, tenderness, rubescent, Pi Wengao and fluctuation.Puncture can extract pus out.Ulceration voluntarily, flows out yellow archepyon.

4. blood leukocytes increases, and hemoculture is often positive.

5, laboratory examination: WBC raises, and ESR accelerates, and CRP increases, blood culture with positive bacteria.

6, ECT: onset can find that infection focus 99mTC absorbs for 48 hours to be increased, but specificity is not high, has certain help to early diagnosis.

7.X ray examination: in early days normally, plain film display in 7 ~ 14 days of falling ill can have osteoclasia, engender spongy bone, sample osteoclasia of damaging by worms, and have periosteal proliferation, no positive discovery, but feminine gender can not get rid of this disease after 2 weeks.And hope according to the traditional Chinese medical science, hear, ask, cut and be dialectically diagnosed as the stagnant type suppurative osteomyelitis of damp and hot heresy further.

Therapeutic Method:

In medication therapy groups:

Tablet in treatment group: take the embodiment of the present invention 1 prepare tablet, every day 3 times, one time 4, within every 30 days, be 1 course for the treatment of;

Capsule treatment group: use the embodiment of the present invention 2 prepare capsule, every day 3 times, one time 2, within every 30 days, be a course for the treatment of.

Oral liquid treatment group: take oral liquid prepared by the embodiment of the present invention 3, every day 3 times, 30ml/ time every 30 days is a course for the treatment of;

Western medicine group: take tanshinone capsule, every day 3 times, each 4 every 30 days is a course for the treatment of.

The standard of curative effect evaluation:

Draft with reference to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect " and carry out curative effect evaluation.Cure: General Symptoms and partial gall disappear, wound healing after bursting, limbs profile and function normally, are recovered normally to work, without pain, sinus tract closes, and X-ray film shows that, without sequestrum dead space, sclerotin focus is repaired, bone density is even, affected part sclerotin is clear, and ESR is on close level or recovers normal, follows up a case by regular visits to and does not recur for 1 year; Effective: General Symptoms and partial gall disappear, and after bursting, wound healing obviously improves, and limbs profile is normal, function is good, can complete general work, without pain, sinus tract basicly stable (sinus tract obviously reduces, and secretions is few), X-ray film shows without sequestrum dead space, sclerotin focus is stablized, bone density is even, local osteosclerosis, and bone destruction is in repairing gradually, ESR is on close level or recovers normal, follows up a case by regular visits to and does not recur for 1 year; Effective: General Symptoms alleviates, after swelling and ache and bursting, the open sore part is more improved, limbs mild malformation, funtion part obstacle, can complete general work, time have pain, sinus tract is basicly stable, sinus tract secretions reduces (or sinus tract reduces), and X-ray film display focus is unstable, and sequestrum is discharged or existed, and sequestrum is repaired gradually, bone density is uneven, local osteosclerosis, and ESR, CRP level reduces gradually; Invalid: General Symptoms and local symptom fail to be controlled, unchanged, cacomelia and dysfunction are comparatively remarkable, and living needs is looked after, time have pain, sinus tract is unstable or leave over sinus tract and do not heal for a long time, and secretions is many, and function is not improved, X-ray film display focus is unstable and continue development, bone density is uneven, and local osteosclerosis, has sequestrum dead space.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt the stagnant type suppurative osteomyelitis of the damp and hot heresy of Drug therapy of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt the stagnant type suppurative osteomyelitis of the damp and hot heresy of Drug therapy of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and efficiently individual quantity and time comparative example (%)

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 170 examples of effective and efficiently individual quantity and western medicine group is cured, effective and effective 20 routine follow-up of patients 1 year half, result is added up, in tablet in treatment group 56 example, healing 23 example and effective 26 examples are all without recurrence, 1 case relapsed in effective 7 examples, and relapse rate is 1.7%; Cure 24 examples in capsule treatment group 57 example without recurrence, 1 case relapsed in effective 27 examples, 1 case relapsed in effective 6 examples, relapse rate is 3.5%; Cure 25 examples, effective 28 examples and effective 4 examples in oral liquid treatment group 57 example all without recurrence, relapse rate is 0%; Western medicine group is cured, effective and efficiently individual quantity 37 example, recurs 2 examples, recurs 7 examples in effective 13 routine patients, recur 9 examples, relapse rate 48.6% in effective 17 examples in 7 routine patients of healing; Above-mentioned recurrence refer to patient outcomes reach healing, effective or effectively after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: Wang, women, 21 years old, because of cacomelia six months, often also can feel limbs disturbance, living needs is looked after, time have pain, sinus tract is unstable, and secretions is many, through x-ray inspection, X-ray film display focus is unstable, and bone density is uneven, local osteosclerosis, have sequestrum dead space, tentative diagnosis is suppurative osteomyelitis; Then hope according to the traditional Chinese medical science, hear, cut and be diagnosed as the stagnant type suppurative osteomyelitis of damp and hot heresy further.Take the tablet of pharmaceutical preparation embodiment 1 of the present invention, every day 3 times, each 4, treat and substantially cure for 2 months, continue two weeks healing of taking medicine, follow up a case by regular visits to and do not recur for 1 year half.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of damp and hot heresy for one kind, it is characterized in that, comprise following raw medicinal material: Ramulus et Folium Tamaricis, Fructus Viticis, Herba Spirodelae, Radix Trichosanthis, Herba Commelinae, Haematitum, Fructus Gardeniae, Radix Puerariae, Radix Scutellariae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix et Rhizoma Thalictri, Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Taraxaci, Caulis Lonicerae, Herba Andrographis, the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae, Radix Stephaniae Tetrandrae, Ramulus Mori, Rhizoma Coptidis, Cortex erythrinae, Caulis Trachelospermi, geranium, Rhizoma Dioscoreae Nipponicae, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Semen Coicis, Semen Lepidii (Semen Descurainiae), Herba Capsellae, Rhizoma Chuanxiong, Rhizoma Corydalis, Rhizoma Curcumae Longae, Olibanum, Myrrha, Resina Liquidambaris, Flos Campsis, Caulis Spatholobi and Herba Leonuri.

2. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy for the treatment of according to claim 1, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 10 ~ 25 parts, Fructus Viticis 12 ~ 24 parts, 15 ~ 30 parts, Herba Spirodelae, Radix Trichosanthis 16 ~ 32 parts, Herba Commelinae 18 ~ 35 parts, Haematitum 10 ~ 30 parts, Fructus Gardeniae 14 ~ 26 parts, Radix Puerariae 11 ~ 24 parts, Radix Scutellariae 12 ~ 30 parts, Radix Sophorae Flavescentis 12 ~ 25 parts, Cortex Dictamni 18 ~ 32 parts, Radix et Rhizoma Thalictri 10 ~ 24 parts, Flos Lonicerae 13 ~ 31 parts, Rhizoma Smilacis Glabrae 10 ~ 25 parts, Herba Taraxaci 18 ~ 30 parts, Caulis Lonicerae 10 ~ 22 parts, Herba Andrographis 8 ~ 21 parts, the Fructus Kochiae 14 ~ 32 parts, Herba Houttuyniae 17 ~ 34 parts, Herba Violae 15 ~ 28 parts, Flos Chrysanthemi Indici 13 ~ 33 parts, Rhizoma Fagopyri Dibotryis 11 ~ 30 parts, Caulis Sargentodoxae 18 ~ 32 parts, Flos Rosae Chinensis 16 ~ 30 parts, Radix Gentianae Macrophyllae 9 ~ 23 parts, Radix Stephaniae Tetrandrae 10 ~ 24 parts, Ramulus Mori 13 ~ 31 parts, Rhizoma Coptidis 18 ~ 30 parts, Cortex erythrinae 12 ~ 24 parts, Caulis Trachelospermi 11 ~ 30 parts, geranium 8 ~ 21 parts, Rhizoma Dioscoreae Nipponicae 13 ~ 30 parts, Herba Taxilli 12 ~ 23 parts, Folium Photiniae (Folium Photiniae serrulatae) 16 ~ 32 parts, Semen Coicis 19 ~ 30 parts, Semen Lepidii (Semen Descurainiae) 17 ~ 35 parts, 12 ~ 24 parts, Herba Capsellae, Rhizoma Chuanxiong 17 ~ 31 parts, Rhizoma Corydalis 13 ~ 27 parts, 19 ~ 30 parts, Rhizoma Curcumae Longae, Olibanum 14 ~ 25 parts, Myrrha 13 ~ 24 parts, Resina Liquidambaris 14 ~ 26 parts, Flos Campsis 11 ~ 24 parts, Caulis Spatholobi 13 ~ 26 parts and Herba Leonuri 10 ~ 20 parts.

3. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy for the treatment of according to claim 1 and 2, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 12 ~ 23 parts, Fructus Viticis 15 ~ 22 parts, 18 ~ 26 parts, Herba Spirodelae, Radix Trichosanthis 19 ~ 30 parts, Herba Commelinae 20 ~ 33 parts, Haematitum 10 ~ 22 parts, Fructus Gardeniae 16 ~ 24 parts, Radix Puerariae 15 ~ 23 parts, Radix Scutellariae 14 ~ 28 parts, Radix Sophorae Flavescentis 16 ~ 24 parts, Cortex Dictamni 19 ~ 30 parts, Radix et Rhizoma Thalictri 12 ~ 22 parts, Flos Lonicerae 15 ~ 27 parts, Rhizoma Smilacis Glabrae 13 ~ 24 parts, Herba Taraxaci 20 ~ 28 parts, Caulis Lonicerae 14 ~ 20 parts, Herba Andrographis 9 ~ 20 parts, the Fructus Kochiae 18 ~ 30 parts, Herba Houttuyniae 19 ~ 32 parts, Herba Violae 16 ~ 25 parts, Flos Chrysanthemi Indici 14 ~ 30 parts, Rhizoma Fagopyri Dibotryis 15 ~ 28 parts, Caulis Sargentodoxae 18 ~ 28 parts, Flos Rosae Chinensis 18 ~ 28 parts, Radix Gentianae Macrophyllae 10 ~ 22 parts, Radix Stephaniae Tetrandrae 12 ~ 20 parts, Ramulus Mori 14 ~ 30 parts, Rhizoma Coptidis 20 ~ 28 parts, Cortex erythrinae 14 ~ 22 parts, Caulis Trachelospermi 13 ~ 27 parts, geranium 9 ~ 20 parts, Rhizoma Dioscoreae Nipponicae 15 ~ 28 parts, Herba Taxilli 15 ~ 20 parts, Folium Photiniae (Folium Photiniae serrulatae) 18 ~ 30 parts, Semen Coicis 20 ~ 28 parts, Semen Lepidii (Semen Descurainiae) 20 ~ 30 parts, 15 ~ 22 parts, Herba Capsellae, Rhizoma Chuanxiong 18 ~ 30 parts, Rhizoma Corydalis 15 ~ 24 parts, 20 ~ 28 parts, Rhizoma Curcumae Longae, Olibanum 15 ~ 24 parts, Myrrha 14 ~ 22 parts, Resina Liquidambaris 15 ~ 25 parts, Flos Campsis 13 ~ 22 parts, Caulis Spatholobi 14 ~ 24 parts and Herba Leonuri 12 ~ 18 parts.

4. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-3, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 16 parts, Fructus Viticis 14 parts, 26 parts, Herba Spirodelae, Radix Trichosanthis 28 parts, Herba Commelinae 25 parts, Haematitum 14 parts, Fructus Gardeniae 16 parts, Radix Puerariae 18 parts, Radix Scutellariae 22 parts, Radix Sophorae Flavescentis 24 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 25 parts, Rhizoma Smilacis Glabrae 19 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 20 parts, Herba Andrographis 18 parts, the Fructus Kochiae 17 parts, Herba Houttuyniae 24 parts, Herba Violae 22 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 26 parts, Caulis Sargentodoxae 22 parts, Flos Rosae Chinensis 25 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 21 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 27 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 18 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 25 parts, Herba Taxilli 15 parts, Folium Photiniae (Folium Photiniae serrulatae) 26 parts, Semen Coicis 24 parts, Semen Lepidii (Semen Descurainiae) 22 parts, 20 parts, Herba Capsellae, Rhizoma Chuanxiong 19 parts, Rhizoma Corydalis 25 parts, 28 parts, Rhizoma Curcumae Longae, Olibanum 20 parts, Myrrha 18 parts, Resina Liquidambaris 24 parts, Flos Campsis 16 parts, Caulis Spatholobi 24 parts and Herba Leonuri 15 parts.

5. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-4, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 17 parts, Fructus Viticis 19 parts, 22 parts, Herba Spirodelae, Radix Trichosanthis 25 parts, Herba Commelinae 27 parts, Haematitum 18 parts, Fructus Gardeniae 18 parts, Radix Puerariae 19 parts, Radix Scutellariae 24 parts, Radix Sophorae Flavescentis 20 parts, Cortex Dictamni 25 parts, Radix et Rhizoma Thalictri 16 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 16 parts, Herba Taraxaci 26 parts, Caulis Lonicerae 18 parts, Herba Andrographis 16 parts, the Fructus Kochiae 24 parts, Herba Houttuyniae 25 parts, Herba Violae 24 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Fagopyri Dibotryis 24 parts, Caulis Sargentodoxae 23 parts, Flos Rosae Chinensis 22 parts, Radix Gentianae Macrophyllae 14 parts, Radix Stephaniae Tetrandrae 16 parts, Ramulus Mori 18 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 19 parts, Caulis Trachelospermi 25 parts, geranium 16 parts, Rhizoma Dioscoreae Nipponicae 24 parts, Herba Taxilli 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 27 parts, Semen Coicis 26 parts, Semen Lepidii (Semen Descurainiae) 26 parts, 19 parts, Herba Capsellae, Rhizoma Chuanxiong 22 parts, Rhizoma Corydalis 21 parts, 25 parts, Rhizoma Curcumae Longae, Olibanum 22 parts, Myrrha 17 parts, Resina Liquidambaris 19 parts, Flos Campsis 16 parts, Caulis Spatholobi 20 parts and Herba Leonuri 15 parts.

6. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-5, is characterized in that, in described pharmaceutical preparation, the ratio of weight and number of each raw medicinal material is: Ramulus et Folium Tamaricis 20 parts, Fructus Viticis 18 parts, 24 parts, Herba Spirodelae, Radix Trichosanthis 23 parts, Herba Commelinae 26 parts, Haematitum 20 parts, Fructus Gardeniae 21 parts, Radix Puerariae 20 parts, Radix Scutellariae 18 parts, Radix Sophorae Flavescentis 22 parts, Cortex Dictamni 26 parts, Radix et Rhizoma Thalictri 17 parts, Flos Lonicerae 24 parts, Rhizoma Smilacis Glabrae 22 parts, Herba Taraxaci 25 parts, Caulis Lonicerae 16 parts, Herba Andrographis 14 parts, the Fructus Kochiae 25 parts, Herba Houttuyniae 23 parts, Herba Violae 21 parts, Flos Chrysanthemi Indici 24 parts, Rhizoma Fagopyri Dibotryis 22 parts, Caulis Sargentodoxae 25 parts, Flos Rosae Chinensis 26 parts, Radix Gentianae Macrophyllae 20 parts, Radix Stephaniae Tetrandrae 19 parts, Ramulus Mori 25 parts, Rhizoma Coptidis 24 parts, Cortex erythrinae 20 parts, Caulis Trachelospermi 24 parts, geranium 14 parts, Rhizoma Dioscoreae Nipponicae 23 parts, Herba Taxilli 19 parts, Folium Photiniae (Folium Photiniae serrulatae) 21 parts, Semen Coicis 25 parts, Semen Lepidii (Semen Descurainiae) 25 parts, 17 parts, Herba Capsellae, Rhizoma Chuanxiong 24 parts, Rhizoma Corydalis 22 parts, 26 parts, Rhizoma Curcumae Longae, Olibanum 21 parts, Myrrha 20 parts, Resina Liquidambaris 21 parts, Flos Campsis 16 parts, Caulis Spatholobi 18 parts and Herba Leonuri 13 parts.

7. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80% ~ 90%, reflux 3 ~ 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 2 ~ 4 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 500 order ~ 800 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.25 ~ 0.5 times of lactose, the starch of 0.2 ~ 0.4 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

8. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

9. the pharmaceutical preparation of the stagnant type suppurative osteomyelitis of the damp and hot heresy of the treatment according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by the Fructus Kochiae, Herba Houttuyniae, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Fagopyri Dibotryis, Caulis Sargentodoxae, Flos Rosae Chinensis, Radix Gentianae Macrophyllae and Radix Stephaniae Tetrandrae mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described pharmaceutical preparation oral liquid finished product.