CN104257871A - Pharmaceutical composition for treating damp-heat toxin-accumulation-type acute erysipelas and preparation method of pharmaceutical composition - Google Patents

Pharmaceutical composition for treating damp-heat toxin-accumulation-type acute erysipelas and preparation method of pharmaceutical composition Download PDF

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CN104257871A
CN104257871A CN201410565892.XA CN201410565892A CN104257871A CN 104257871 A CN104257871 A CN 104257871A CN 201410565892 A CN201410565892 A CN 201410565892A CN 104257871 A CN104257871 A CN 104257871A
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weight portion
radix
herba
pharmaceutical composition
damp
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CN104257871B (en
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苏琳
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Hangzhou Jin Pei Science And Technology Ltd
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Abstract

The invention discloses a pharmaceutical composition for treating damp-heat toxin-accumulation-type acute erysipelas. The pharmaceutical composition includes an oral drug and an external-application drug, wherein the oral drug is prepared from the following raw medicinal materials: stephania japonica, xylocopa dissimilis, calamint, parget, berberis thunbergii, commelina communis, scutellaria baicalensis, coptis chinensis, radix sophorae flavescentis, herba portulacae, Chinese lobelia, uniflower swisscentaury roots, humifuse euphorbia herb, moutan bark, radix scrophulariae, radices lithospermi, mangnolia officinalis, pericarpium citri reticulatae, rhizoma atractylodis, herba aristolochiae, small-leaved desmodium, longan roots, pine needles, erodium stephanianum willd, bark of himalayan coralbean, the root of fangji, resina liquidamberis, the root of red-rooted salvia and rosa chinensis; the external-application drug is prepared from the following raw medicinal materials: stephania japonica, xylocopa dissimilis, parget, root and rhizome of canton fairybells, herb of vaiante spleenwort, herb of floppers, resina liquidamberis, propolis and leaves and twigs of nakedflower beautyberry. The pharmaceutical composition for treating the damp-heat toxin-accumulation-type acute erysipelas and a preparation method of the pharmaceutical composition have the following benefits: the pharmaceutical composition for treating the damp-heat toxin-accumulation-type acute erysipelas has the advantages of being quick and good in curative effect, high in safety, free of toxic or side effects and low possibility of relapsing.

Description

Be used for the treatment of damp and hot poison and accumulate pharmaceutical composition of the acute lymphatic meshwork inflammation of type and preparation method thereof
 
Technical field
The present invention relates to pharmaceutical technology, particularly relate to one and be used for the treatment of damp and hot poison and accumulate pharmaceutical composition of type acute lymphatic meshwork inflammation (damp and hot poison accumulates type erysipelas) and preparation method thereof.
 
Background technology
Medically acute lymphangitis is divided into three kinds of situations: localized infection calling " lymphatic meshwork is scorching " in skin endolymph net, local red and swollen heat pain, demarcate obviously with normal structure, there is vesicle or have transudate in surface sometimes; Pathological changes is when superficial part lymphatic vessel, and cry " shallow-layer lymphatic vessel ", in one or more red line, red line is hard, has tenderness, guides lymph node into from primary infection place, and this kind of lymphangitis is more common; Pathological changes prolong and deep lymphatic vessel time, crying " deep layer lymphangitis ", whole swelling of limb being caused with attacking pain.Wherein, acute lymphatic meshwork inflammation be a kind of with A group β Hemolytic streptococcus for Main Pathogenic Bacteria via below surgical wound or nostril, external auditory meatus, ear-lobe, anus, crack between penis and toe, to chap or ulcer portion invades and involves the vasculolymphatic infection of high dermis, cause the infectious disease that acute contact infects.Be common in child and old people, the whole year all can fall ill, multiple with spring, autumn.
The clinical manifestation of acute lymphatic meshwork inflammation: be apt to occur in lower limb and face.Its clinical manifestation is that onset is anxious, and the lamellar erythema of boundary clear appears in local, and color is scarlet, and slightly swells, fading of pressure.Skin surface anxiety is red-hot, is rapidly to surrounding and spreads, and burns sample pain.Accompany high hot fear of cold and headache etc.
Chinese medicine thinks that acute lymphatic meshwork inflammation belongs to motherland's medical science " erysipelas " category.Erysipelas is in flakes scarlet with the unexpected skin of affected part, and color is as being coated with pellet, and scorching hot swelling, rapid spread is the acute infectious diseases of main manifestations." Plain Questions the most pure virginity will be discussed greatly " cloud: " few sun department sky, visitor's victory then red rash outgoing, and be red Lisu Nationality skin infection ... " " the sick duke or princess under an emperor of General Treatise on the Cause and Symptoms of Diseases erysipelas " cloud: " and red person, the person lifts red suddenly, as the shape of pellet painting, therefore the pellet of meaning.Or send out in foot, or send out on abdomen, as palm is large, all wind heat is vicious does.Severe one, also has cellulitis and so on, does not suddenly control, then pain can not be born, and is bad rotten for a long time." primary disease skin lesion appearing without definite location, be born in Xiong Fu waist crotch person, claim erysipelas in the lower part of the trunk; Send out in Head And Face person, claim erysipelas on the head; Send out in shank foot person, claim erysipelas; Neonate is born in buttocks more, claims red wandering erysipelas.Because ferritic blood system has heat, outward by fire-toxin, pyretic toxicity pents up, strongly fragrant resistance skin and sending out; Or due to mucocutaneous broken wound (tinea pedis is rotten to the corn, insect-bite, ecthyma etc. for wound as broken in nasal membrane, ear channel skin or scalp, skin abrasion), the intrusion of taking advantage of a loophole of malicious heresy forms.In Head And Face person, hold wind heat under the arm for all; Send out in Xiong Fu waist crotch person, held liver-fire under the arm; Send out in lower limb person, held under the arm damp and hot; Send out in neonate person, how caused by fetal heat in pregnancy fire-toxin.Majority betides lower limb, is secondly Head And Face.Neonate erysipelas is often migrans.The medical histories such as skin, mucosa breakage can be had.Fall ill hurried, from the beginning of often first there being fever with aversion to cold, headache bone Chu, infantile anorexia, constipation urinate the General Symptoms such as red.Continue, locally see small pieces erythema, rapid spread becomes large stretch of scarlet speckle, slightly exceeds skin surface, clear border, and the skin redness of pressure slightly moves back, and recovers immediately after letting go, the nervous light in surface, and the hands that burns touched, swelling, tenderness are obviously.General prognosis bona, about disappeared after 5-6 days, color of the leather by scarlet turn of dark red or brown color, last desquamation and healing.The person of being in a bad way, can occur together petechia, purpura or the vesicle differed in size at red and swollen place, occasionally has suppuration or cutaneous necrosis.Also have while disappear, development, successively, touching several weeks person.Near affected part, administration endorses and swells and ache.Send out in shank person, easily recurrence more, often because of recurrent exerbation, pachylosis thickens, lower extremity swelling and distension and form elephantiasis crus.The normal migration of neonate erysipelas is indefinite, has cutaneous necrosis more, and General Symptoms is serious.Primary disease moves towards breast abdomen person by extremity or women's head-ornaments, is deteriorating syndrome.Neonate and elderly and infirm, fire-toxin is flourishing, easily causes pathogenic poison invading toward interior, sees the General Symptomies such as high fever agitation, unconsciousness and delirium, nausea and vomiting, even threat to life.Therefore distinguish that its clinical disease is divided into: wind heat poison accumulates, damp and hot poison accumulates, tire fire accumulates poison, and wherein damp and hot poison accumulates type: send out in lower limb, local red red swelling, scorching hot pain, or water breakthrough bleb, purpura, even knot poison pus or cutaneous necrosis; Grade fever can be accompanied, infantile anorexia; Red tongue, yellow and greasy fur, slippery and rapid pulse.Recurrent exerbation, can form elephantiasis crus.
At present, the method for this sick acute attack of western medical treatment uses enough effective antibiotics, and symptom management is rapid, but toxic and side effects is more, easily produces drug resistance, lacks effective prevention and controls to its recurrence.Large-area erysipelas as controlled not in time, then can produce the possibility of multiple complications, as toxic shock, septicemia, multiple organs failure etc., and the life security of crisis patient.
 
Summary of the invention
Technical problem to be solved by this invention is that providing one to be used for the treatment of damp and hot poison accumulates pharmaceutical composition of type acute lymphatic meshwork inflammation (damp and hot poison accumulates type erysipelas) and preparation method thereof, this pharmaceutical composition comprises endo-medicine and external used medicine, endo-medicine is with heat-clearing and toxic substances removing, pathogenic fire purging dampness removing is main, with clearing away heat and cooling blood, to regulate the flow of vital energy dampness, spleen invigorating, dredging collateral is auxiliary, external used medicine is with heat-clearing and toxic substances removing, blood activating and promoting tissue regeneration, anti-inflammatory analgetic is Therapeutic Principle, oral administration and externally interacts, treat damp and hot poison to accumulate type acute lymphatic meshwork inflammation and have rapid-action, good effect, safety is high, the advantage having no side effect and not easily recur.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type, described pharmaceutical composition comprises endo-medicine and external used medicine, described endo-medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Herba Clinopodii Polycephali, Gypsum Fibrosum, Radix Berberidis Amurensis, Herba Commelinae, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Portulacae, Herba Lobeliae Chinensis, Radix Rhapontici, Herba Euphorbiae Humifusae, Cortex Moutan, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Herba Aristolochiae, Herba desmodii microphylli, Radix Longan, Folium Pini, geranium, Cortex erythrinae, Radix Stephaniae Tetrandrae, Resina Liquidambaris, Radix Salviae Miltiorrhizae and Flos Rosae Chinensis,
Described external used medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Gypsum Fibrosum, Radix et Rhizoma Dispori Cantoniensis, Herba Asplenii Vaiainte Spleenwort, Herba Bryophylli Pinnati, Resina Liquidambaris, propolis and Folium et Ramulus Callicarpae nudiflorae.
In described endo-medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 11-18 weight portion, Xylocopa dissimilis (Lep.) 10-15 weight portion, Herba Clinopodii Polycephali 8-15 weight portion, Gypsum Fibrosum 5-13 weight portion, Radix Berberidis Amurensis 7-12 weight portion, Herba Commelinae 12-18 weight portion, Radix Scutellariae 7-14 weight portion, Rhizoma Coptidis 15-19 weight portion, Radix Sophorae Flavescentis 6-12 weight portion, Herba Portulacae 4-8 weight portion, Herba Lobeliae Chinensis 9-18 weight portion, Radix Rhapontici 7-15 weight portion, Herba Euphorbiae Humifusae 5-17 weight portion, Cortex Moutan 9-20 weight portion, Radix Scrophulariae 7-15 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Cortex Magnoliae Officinalis 10-16 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Rhizoma Atractylodis 11-18 weight portion, Herba Aristolochiae 9-13 weight portion, Herba desmodii microphylli 9-15 weight portion, Radix Longan 9-15 weight portion, Folium Pini 5-12 weight portion, geranium 8-15 weight portion, Cortex erythrinae 7-15 weight portion, Radix Stephaniae Tetrandrae 8-15 weight portion, Resina Liquidambaris 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion and Flos Rosae Chinensis 11-17 weight portion.
In described external used medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 15-20 weight portion, Xylocopa dissimilis (Lep.) 10-18 weight portion, Gypsum Fibrosum 8-15 weight portion, Radix et Rhizoma Dispori Cantoniensis 5-12 weight portion, Herba Asplenii Vaiainte Spleenwort 9-17 weight portion, Herba Bryophylli Pinnati 5-15 weight portion, Resina Liquidambaris 5-10 weight portion, propolis 5-10 weight portion and Folium et Ramulus Callicarpae nudiflorae 10-15 weight portion.
In described endo-medicine, the parts by weight of each raw medicinal material are preferably: Radix Stephaniae Japonicae 14 weight portion, Xylocopa dissimilis (Lep.) 12 weight portion, Herba Clinopodii Polycephali 11 weight portion, Gypsum Fibrosum 9 weight portion, Radix Berberidis Amurensis 9 weight portion, Herba Commelinae 15 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Coptidis 17 weight portion, Radix Sophorae Flavescentis 9 weight portion, Herba Portulacae 6 weight portion, Herba Lobeliae Chinensis 13 weight portion, Radix Rhapontici 11 weight portion, Herba Euphorbiae Humifusae 11 weight portion, Cortex Moutan 14 weight portion, Radix Scrophulariae 11 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Atractylodis 14 weight portion, Herba Aristolochiae 11 weight portion, Herba desmodii microphylli 12 weight portion, Radix Longan 12 weight portion, Folium Pini 8 weight portion, geranium 11 weight portion, Cortex erythrinae 11 weight portion, Radix Stephaniae Tetrandrae 11 weight portion, Resina Liquidambaris 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion and Flos Rosae Chinensis 14 weight portion.
In described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Stephaniae Japonicae 18 weight portion, Xylocopa dissimilis (Lep.) 15 weight portion, Herba Clinopodii Polycephali 15 weight portion, Gypsum Fibrosum 13 weight portion, Radix Berberidis Amurensis 12 weight portion, Herba Commelinae 12 weight portion, Radix Scutellariae 7 weight portion, Rhizoma Coptidis 15 weight portion, Radix Sophorae Flavescentis 6 weight portion, Herba Portulacae 4 weight portion, Herba Lobeliae Chinensis 9 weight portion, Radix Rhapontici 15 weight portion, Herba Euphorbiae Humifusae 17 weight portion, Cortex Moutan 20 weight portion, Radix Scrophulariae 7 weight portion, Radix Arnebiae (Radix Lithospermi) 7 weight portion, Cortex Magnoliae Officinalis 16 weight portion, Pericarpium Citri Reticulatae 20 weight portion, Rhizoma Atractylodis 11 weight portion, Herba Aristolochiae 9 weight portion, Herba desmodii microphylli 15 weight portion, Radix Longan 15 weight portion, Folium Pini 12 weight portion, geranium 8 weight portion, Cortex erythrinae 7 weight portion, Radix Stephaniae Tetrandrae 8 weight portion, Resina Liquidambaris 10 weight portion, Radix Salviae Miltiorrhizae 10 weight portion and Flos Rosae Chinensis 11 weight portion.
In described external used medicine, the parts by weight of each raw medicinal material are preferably: Radix Stephaniae Japonicae 17 weight portion, Xylocopa dissimilis (Lep.) 14 weight portion, Gypsum Fibrosum 11 weight portion, Radix et Rhizoma Dispori Cantoniensis 8 weight portion, Herba Asplenii Vaiainte Spleenwort 13 weight portion, Herba Bryophylli Pinnati 10 weight portion, Resina Liquidambaris 8 weight portion, propolis 7 weight portion and Folium et Ramulus Callicarpae nudiflorae 12 weight portion.
In described external used medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 20 weight portion, Xylocopa dissimilis (Lep.) 10 weight portion, Gypsum Fibrosum 8 weight portion, Radix et Rhizoma Dispori Cantoniensis 5 weight portion, Herba Asplenii Vaiainte Spleenwort 17 weight portion, Herba Bryophylli Pinnati 15 weight portion, Resina Liquidambaris 10 weight portion, propolis 10 weight portion and Folium et Ramulus Callicarpae nudiflorae 15 weight portion.
In order to better realize foregoing invention object, the invention provides a kind of preparation method being used for the treatment of damp and hot poison and accumulateing the pharmaceutical composition of the acute lymphatic meshwork inflammation of type, when the dosage form of endo-medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
When the dosage form of endo-medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
When the dosage form of external used medicine is ointment, its preparation method comprises the following steps: the crude drug getting the described ratio of weight and number except Resina Liquidambaris and propolis soaks 1-2 hour, then multi-function extractor is placed in, first time decocts 5-10 times that amount of water is medical material, decocts, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling; Add in extractum after Resina Liquidambaris and propolis are pulverized, tinning after ultraviolet radiation sterilizing.
When the dosage form of external used medicine is liniment, its preparation method comprises the following steps:
Step one: first the described raw medicinal material except Resina Liquidambaris and propolis is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: Resina Liquidambaris and propolis powder are broken into powder, and call in glycerol after mixing with fine powder b with fine powder a and make liniment.
 
The invention has the beneficial effects as follows: the theory of Chinese medical science that pharmaceutical composition of the present invention utilizes China traditional, comprise endo-medicine and external used medicine, endo-medicine is based on heat-clearing and toxic substances removing, pathogenic fire purging dampness removing, be auxiliary with clearing away heat and cooling blood, dampness of regulating the flow of vital energy, spleen invigorating, dredging collateral, external used medicine with heat-clearing and toxic substances removing, blood activating and promoting tissue regeneration, anti-inflammatory analgetic for Therapeutic Principle, when the two uses simultaneously, best results, oral administration and externally interacts, and treats damp and hot poison and accumulates type acute lymphatic meshwork inflammation and have the advantage that rapid-action, good effect, safety are high, have no side effect and not easily recur.
 
Detailed description of the invention
Chinese medicine is thought, primary disease has heat due to ferritic blood system, and outward by fire-toxin, pyretic toxicity pents up, strongly fragrant resistance skin and sending out; Or due to mucocutaneous broken wound (tinea pedis is rotten to the corn, insect-bite, ecthyma etc. for wound as broken in nasal membrane, ear channel skin or scalp, skin abrasion), the intrusion of taking advantage of a loophole of malicious heresy forms.In Head And Face person, hold wind heat under the arm for all; Send out in Xiong Fu waist crotch person, held liver-fire under the arm; Send out in lower limb person, held under the arm damp and hot; Send out in neonate person, how caused by fetal heat in pregnancy fire-toxin.Acute lymphatic meshwork is scorching damp and hotly accumulates poison card damp invasion of lower energizer, and feel exopathogen again, Shi Re Bing Pian becomes silted up and ties in lower limb, strongly fragrant resistance skin, and meridians block, thus the red red swelling in local, scorching hot pain, or water breakthrough bleb, purpura; Excessive noxious heat, corruption muscle, therefore notably can poison pus, skin necrosis to knot; Hinder in damp, therefore see infantile anorexia; Red tongue, yellow and greasy fur, slippery and rapid pulse are resembling of damp-heat accumulation.Damp pathogen being sticky and stagnant in nature, with thermosetting, therefore easy recurrent exerbation.Therefore, the invention provides one and be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates type acute lymphatic meshwork inflammation (damp and hot poison accumulates type erysipelas), comprise endo-medicine and external used medicine, endo-medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Herba Clinopodii Polycephali, Gypsum Fibrosum, Radix Berberidis Amurensis, Herba Commelinae, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Portulacae, Herba Lobeliae Chinensis, Radix Rhapontici, Herba Euphorbiae Humifusae, Cortex Moutan, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Herba Aristolochiae, Herba desmodii microphylli, Radix Longan, Folium Pini, geranium, Cortex erythrinae, Radix Stephaniae Tetrandrae, Resina Liquidambaris, Radix Salviae Miltiorrhizae and Flos Rosae Chinensis; External used medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Gypsum Fibrosum, Radix et Rhizoma Dispori Cantoniensis, Herba Asplenii Vaiainte Spleenwort, Herba Bryophylli Pinnati, Resina Liquidambaris, propolis and Folium et Ramulus Callicarpae nudiflorae.
Wherein, Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Herba Clinopodii Polycephali, Gypsum Fibrosum, Radix Berberidis Amurensis, Herba Commelinae, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Portulacae, Herba Euphorbiae Humifusae, Herba Lobeliae Chinensis, Radix et Rhizoma Dispori Cantoniensis clearing away heat-fire, detoxification and promoting urination; Radix Rhapontici, Herba Euphorbiae Humifusae, Cortex Moutan, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi) clearing away heat and cooling blood; Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Herba Aristolochiae are regulated the flow of vital energy dampness, spleen invigorating; Herba desmodii microphylli, Radix Longan, Folium Pini, geranium, Cortex erythrinae, Radix Stephaniae Tetrandrae dampness removing dredging collateral; Resina Liquidambaris, Radix Salviae Miltiorrhizae, propolis, Folium et Ramulus Callicarpae nudiflorae, Flos Rosae Chinensis promoting blood circulation and stopping pain; Propolis, Herba Asplenii Vaiainte Spleenwort, Herba Bryophylli Pinnati blood activating and promoting tissue regeneration.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Radix Stephaniae Japonicae: bitter, acrid, cold.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, wind-expelling pain-stopping.For laryngopharynx swelling and pain, toothache, stomachache, edema, beriberi, urgent micturition dysurea, dysuria, vulval eczema, rheumatic arthritis; Traumatic injury is controlled in external, venom, carbuncle furuncle.
Xylocopa dissimilis (Lep.): sweet, sour, cold.Function cures mainly: clearing away heat-fire, dispels the wind.For tooth { worm worm of hideing }, aphtha, pharyngalgia, infantile convulsion.
Herba Clinopodii Polycephali: pungent, bitter, cool.Function cures mainly: wind and heat dispersing, removing toxic substances dysentery relieving, hemostasis.For flu, heatstroke, dysentery, hepatitis; Furuncle swelling toxin, skin pruritus, traumatic hemorrhage are controlled in external.
Gypsum Fibrosum: sweet, pungent, Great Cold.Attach to the lung and stomach meridians.Function cures mainly: clearing away heat-fire, and relieving restlessness is quenched the thirst.For fever caused by exogenous pathogenic factors, high hot excessive thirst, dyspnea and cough due to lung-heat, the high Sheng of stomach-fire, headache, toothache.
Radix Berberidis Amurensis: bitter, cold.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For bacillary dysentery, gastroenteritis, paratyphoid fever, dyspepsia, jaundice, cirrhotic ascites, urinary system infection, acute nephritis, tonsillitis, stomatitis, bronchitis; Otitis media is controlled in external, conjunctival congestion and swelling pain, trauma infection contamination.
Herba Commelinae: sweet, light, cold.Return lung, stomach, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.For anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.
Radix Scutellariae: have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.
Rhizoma Coptidis: (root) is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Cure mainly: hot dampness, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The diseases such as 1, vomiting damp and hot for retention of damp-heat in the interior, the intestines and stomach, dysentery.Join Radix Scutellariae, Radix Et Rhizoma Rhei etc., the card of retention of damp-heat in the interior can be controlled.Be reluctant to leave the intestines and stomach to damp and hot, often coordinate the Rhizoma Pinelliae, Caulis Bambusae In Taenia; Join the Radix Aucklandiae, Radix Scutellariae, Radix Puerariae etc. to control dysentery.2, for epidemic febrile disease high heat, thirsty agitation, bleeding due to blood-heat and pathopyretic ulcer etc.Control the high heat of epidemic febrile disease, hyperactivity of heart-fire, compatibility Fructus Gardeniae, Fructus Forsythiae etc.; For bleeding due to blood-heat, can compatibility Radix Scutellariae, Radix Et Rhizoma Rhei is equivalent uses; To pathopyretic ulcer, can the medicine such as compatibility Radix Paeoniae Rubra, Cortex Moutan with using.In addition, Rhizoma Coptidis also can be used for disappearing in excessiveness of stomach-fire card, can coordinate the equivalent use of Radix Trichosanthis, the Rhizoma Anemarrhenae, the Radix Rehmanniae; Be coated with mouth, can aphtha of the mouth and tongue be controlled.　
Radix Sophorae Flavescentis: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.1. pudendal pruritus under treatment belt.To women's leucorrhea with yellow discharge, and male's swelling of the vulva pudendal pruritus all has good therapeutical effect.2, eczema scabies is treated.Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to the skin pruritus that eczema scabies causes.3. treat dysuria.Radix Sophorae Flavescentis bath can treat the dysuria that a variety of causes causes, scorching hot puckery pain.Especially to the dysuria that women causes because of gestation, coordinate and take Radix Sophorae Flavescentis decoction effect more.Modern effect: 1. beautifying skin-protection function: cold in nature, has heat clearing and damp drying, effect of parasite killing, Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to skin pruritus, vegetable Chinese herbal medicine can Bergamot Mint Extract, dredge and restrain pore, removing skin endotoxin contamination, abundant herbal nutrition, promote growth and the reparation of damaged blood vessels neurocyte, recover subcutaneous capillary cell viability, skin reproduction is compacted fine and smooth, plays the effect of beauty and skin care.2. antibacterial action: Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus; Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly difficult to understand little spore tinea bacterium etc.3. antitumor action: matrine has inhibitory action to mice ehrlich carcinoma and S-180 in vivo and in vitro.4. leukogenic effect: Radix Sophorae Flavescentis total alkaloids and oxymatrine have obvious leukogenic effect, has obvious therapeutical effect to the leukopenia that cyclophosphamide, X-ray and cobalt roentgenization cause.5. antiinflammatory action: the mouse peritoneal that the auricle edema that matrine causes mouse knoting oil, acetic acid cause oozes out increase, Rat Carrageenan colloidality footpad swelling, all has inhibitory action.
Herba Portulacae: acid, cold.Return liver, large intestine channel.Be applicable to dysentery, heat-clearing and toxic substances removing, cooling blood for hemostasis.For toxic-heat and blood stasis, carbuncle furuncle, dermatomycosis, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis." open value greatly surely new book on Chinese herbal medicine ": " Herba Portulacae, clothes not white all the year round." " Bencao Jingshu ": " and not white all the year round, its removing heat from blood benefit blood of total speech, the merit ear that disease goes body light.”
Herba Lobeliae Chinensis: sweet in the mouth; Property is put down.GUIXIN warp, lung meridian, small intestine meridian." Luchuan book on Chinese herbal medicine ": " detoxicating, relieving inflammation, diuresis, hemostasia and promoting granulation.Control ascites, infantile convulsion, two unilateral tonsillitis, dermatitis rhus, traumatic hemorrhage, skin scabies, Serpentis honeybee scorpion hinders." function heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly in venom, carbuncle furuncle, tonsillitis, warm rash, tinea pedis, traumatic injury, jaundice due to damp-heat, appendicitis, enteritis, nephritis, cirrhotic ascites and kinds cancer.
Radix Rhapontici: bitter, cold.Return stomach warp.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle, stimulating milk secretion, and relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture.
Herba Euphorbiae Humifusae: pungent, flat.Return liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enter the heart, liver, kidney channel, there is clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury, the cards such as beriberoid pyretic arthralgia, Cortex Moutan is to bacillus subtilis, escherichia coli, Bacillus typhi, Salmonella paratyphi, Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, vibrio cholera etc. all have stronger antibacterial action, " Bencao Jingshu ": Cortex Moutan, its bitter in the mouth and micro-pungent, its gas is cold and nontoxic, pungent poly-with eliminating stagnation, bitter cold is except heat in blood, enter blood system, the key medicine of removing heat from blood heat also.Cold and heat person, the time of YinXuXueRe also.Apoplexy clonic convulsion, convulsion, infantile convulsion, all yin asthenia generating intrinsic heat, the event of nutrient QI and blood being insufficient.Heat goes then blood cool, and cool then fresh blood is raw, cloudy gas is multiple, and then fire is scorching and without the card because of hot air wind producing again for cloudy gas, therefore knows master's.Carbuncle skin ulcer person, heat is stopped up blood stasis and is formed also.Removing heat from blood promoting the circulation of blood, therefore treat carbuncle skin ulcer.The pungent blood that can fall apart, hardship can be purged heat, therefore can remove blood system pathogen, and the hard blood stasis of disease stays house the intestines and stomach.Cloudy and the store essential substances of dirty genus, the clear and aversion to heat of happiness, evanescence of heat then the five internal organs from peace." not Lu " main seasonal epidemic pathogens headache exopathogenic heat, five kinds of over strain consumptive disease, head lumbago person, the merit of the removing heat from blood that expels the heat-evil also.Main warp arteries and veins is obstructed again for Zhen Quan, blood drop lumbago, and this time that all blood is withered because of heat also.The blood fire second of the three ten-day periods of the hot season, non-this does not remove, therefore it is lossless to control hectic fever due to YIN-deficiency, and children's's smallpox variola skin ulcer, heat in blood.Dong Yuan calls accumulated heat in gastrointestinal tract of having a guilty conscience, and heart-fire is very vehement, deficiency of heart-QI person, take Cortex Moutan as monarch, and also this meaning also.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel.Compendium of Material Medica: " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." " Japan hanako materia medica ": " control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.
Radix Arnebiae (Radix Lithospermi): sweet, salty, cold.GUIXIN, Liver Channel.Function cures mainly: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Cortex Magnoliae Officinalis: Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively causes saliva, gastric secretion, gastrointestinal peristalsis to accelerate, and has stomach invigorating digestion-aid effect; The checking of resisting pathogenic microbes acting body exterior-excess is bright, and Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis; Decoct has inhibitory action to Bufo siccus isolated heart. magnocurarine drug administration by injection, having obvious hypotensive effect lower than during muscle relaxant amount, this effect can not by antihistaminic institute antagonism, the blood pressure lowering of Bolos intravenous administration is held time and is about 10 ~ 15 minutes, and the blood pressure lowering of intramuscular administration is held time, and can reach more than 1 hour.The tincture hydrotrope of Flos Magnoliae Officinalis all has hypotensive effect to anesthetized cat, the quiet note of rabbit or intramuscular injection, and can make increased heart rate.
Pericarpium Citri Reticulatae: temperature; Pungent, bitter; Return the bitter substance of spleen, lung meridian Pericarpium Citri Reticulatae with limonin and bitter principle for representative " limonoid ", this limonoid taste is gentle, soluble in water, contributes to the digestion of food.When Pericarpium Citri Reticulatae is used for cooking dishes.Its bitterness and other tastes are in harmonious proportion mutually, can form original in style local flavor.Pericarpium Citri Reticulatae contains the compositions such as volatile oil, hesperidin, vitamin B, C, and the volatile oil contained by it has gentle stimulation to gastrointestinal tract, can the secretion of facilitating digestion liquid, gets rid of pneumatosis in intestinal tube, increases appetite.Pericarpium Citri Reticulatae is also conventional Chinese medicine simply, has effect of the spleen invigorating of ventilation, drying dampness to eliminate phlegm, the greasy lasting of solution, stopping nausea and vomiting by lowering the adverse flow of QI.
Rhizoma Atractylodis: pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; Asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; Exterior syndrome folder is wet; Head heavy sensation of the body pain; Arthromyodynia warm nature; Podomere is ached and is weighed; Flaccidity folds in a garment.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Rhizoma Atractylodis have drying damp and strengthening spleen, effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia." pearl sac " day: " stomach invigorating can pacify spleen, non-this of all damp-edema can not remove." Compendium of Material Medica says: " control damp-phlegm prolonged fluid-retention ... and spleen wets dirty, turbid drop leukorrhagia, slides and rushes down hemorrhoidal hamorrhage." " Newly Revised Canon of Materia Medica " claim it can " diuresis ".
Herba Aristolochiae: bitter, temperature.Return liver,spleen,kidney warp.Function cures mainly: promoting flow of QI and blood, inducing diuresis to remove edema.For gastral cavity ventral spine pain, arthralgia, edema during pregnancy.
Herba desmodii microphylli: heat clearing away, dampness removing, removing toxic substances.Control urinary system calculus, chronic gastritis, chronic tracheitis, infantile malnutrition, carbuncle carbuncle on the back, hemorrhoid, dermatitis rhus.
Radix Longan: bitter; Puckery; Flat.Return large intestine channel.Function cures mainly: eliminating damp-heat; Change and turbidly exempt from numbness.Main chyluria; Leucorrhea; Erysipelas; Damp and hot arthralgia pain
Folium Pini: bitter, puckery, temperature.Function cures mainly: expelling wind and activating blood circulation, and improving eyesight is calmed the nerves, removing toxic substances, antipruritic.For influenza, rheumatic arthritis, treating swelling and pain by traumatic injury, nyctalopia, hypertension, neurasthenia; External treating chilblain.
Geranium: bitter, for pungent is flat.Return liver, kidney, large intestine channel.Function cures mainly: remove rheumatism.For rheumatic arthralgia.
Cortex erythrinae: bitter is flat.Return liver, kidney channel.Function cures mainly: wind-damp dispelling, channels sootheing and network vessel quickening.For rheumatic numbness, waist hamstring bone pain, traumatic injury; Various stubborn dermatitis is controlled in external.
Radix Stephaniae Tetrandrae: bitter, cold.Return bladder, lung meridian.Function cures mainly: inducing diuresis to remove edema, wind-expelling pain-stopping.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia; Hypertension.
Resina Liquidambaris: pungent, micro-hardship is flat.Return lung, spleen channel.Function cures mainly: promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood.For injury from falling down, ulcer sore pain, spits blood, epistaxis, traumatic hemorrhage.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Flos Rosae Chinensis: sweet, light, the micro-hardship of nature and flavor is flat.Return Liver Channel.Effect had: promoting blood flow to regulate menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI, subduing swelling and detoxicating.Cure mainly stagnation of liver-QI stasis, menoxenia, dysmenorrhea, amenorrhea and distending pain in the chest and hypochondrium; Traumatic injury, pain caused by ecchymoma, swollen ulcer drug, scrofula.
Radix et Rhizoma Dispori Cantoniensis: bitter in the mouth; Pungent; Cool in nature.Function cures mainly: wind-damp dispelling; Relaxing muscles and tendons to promote blood circulation; Heat clearing away expelling phlegm for arresting cough.Main air arthralgia chiefly caused by damp pathogen is demonstrate,proved; Joint lumbago and skelalgia; Traumatic injury; Fracture; Asthenia; Osteopyrexia and fever; Pulmonary tuberculosis is spat blood; Cough due to lung-heat; Burn and scald.
Herba Asplenii Vaiainte Spleenwort: cool; Micro-puckery.Return kidney channel.Function cures mainly: promoting blood circulation and detumescence; Hemostasia and promoting granulation.Operator wound; Fracture; Skin infection festers; Burn and scald
Herba Bryophylli Pinnati: light, micro-acid, puckery, cool.Function cures mainly: removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain, removing toxic substances and promoting tissue regeneration.Carbuncle pyogenic infections from tumour or sore is controlled in external, mastitis, erysipelas, panaris, traumatic hemorrhage, traumatic injury, fracture, burn and scald, otitis media.
Propolis: taste is micro-sweet; Property is put down.Return liver; Spleen channel, function cures mainly: skin moistening granulation promoting; Anti-inflammatory analgetic.Main gastric ulcer; Oral ulcer; Cervical erosion; Herpes zoster; Corii Bovis seu Bubali is considered to be worth doing; Psoriasis; Skin splitting pain; Clavus; Burn and scald.
Folium et Ramulus Callicarpae nudiflorae: puckery micro-arduous; Flat.GUIXIN warp.Function cures mainly: dissipating blood stasis stops blooding; Removing toxic substances and promoting subsidence of swelling.Main epistaxis; Hemoptysis; Spit blood; Have blood in stool; Traumatic injury congestive edema; Traumatic hemorrhage; Burn due to hot liquid or fire; Sore festers.
 
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 capsule
Embodiments provide a kind of endo-medicine being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type, wherein the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 14 weight portion, Xylocopa dissimilis (Lep.) 12 weight portion, Herba Clinopodii Polycephali 11 weight portion, Gypsum Fibrosum 9 weight portion, Radix Berberidis Amurensis 9 weight portion, Herba Commelinae 15 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Coptidis 17 weight portion, Radix Sophorae Flavescentis 9 weight portion, Herba Portulacae 6 weight portion, Herba Lobeliae Chinensis 13 weight portion, Radix Rhapontici 11 weight portion, Herba Euphorbiae Humifusae 11 weight portion, Cortex Moutan 14 weight portion, Radix Scrophulariae 11 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Atractylodis 14 weight portion, Herba Aristolochiae 11 weight portion, Herba desmodii microphylli 12 weight portion, Radix Longan 12 weight portion, Folium Pini 8 weight portion, geranium 11 weight portion, Cortex erythrinae 11 weight portion, Radix Stephaniae Tetrandrae 11 weight portion, Resina Liquidambaris 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion and Flos Rosae Chinensis 14 weight portion,
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.3:0.2, incapsulate in housing by described capsule 's content, obtain capsule finished product.
 
Embodiment 2 tablet
Embodiments provide a kind of endo-medicine being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type, wherein the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 14 weight portion, Xylocopa dissimilis (Lep.) 12 weight portion, Herba Clinopodii Polycephali 11 weight portion, Gypsum Fibrosum 9 weight portion, Radix Berberidis Amurensis 9 weight portion, Herba Commelinae 15 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Coptidis 17 weight portion, Radix Sophorae Flavescentis 9 weight portion, Herba Portulacae 6 weight portion, Herba Lobeliae Chinensis 13 weight portion, Radix Rhapontici 11 weight portion, Herba Euphorbiae Humifusae 11 weight portion, Cortex Moutan 14 weight portion, Radix Scrophulariae 11 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Atractylodis 14 weight portion, Herba Aristolochiae 11 weight portion, Herba desmodii microphylli 12 weight portion, Radix Longan 12 weight portion, Folium Pini 8 weight portion, geranium 11 weight portion, Cortex erythrinae 11 weight portion, Radix Stephaniae Tetrandrae 11 weight portion, Resina Liquidambaris 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion and Flos Rosae Chinensis 14 weight portion,
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.025 times of magnesium stearate, granulate, tabletting, makes.
 
Embodiment 3 ointment
Embodiments provide a kind of external used medicine being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type, wherein the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 17 weight portion, Xylocopa dissimilis (Lep.) 14 weight portion, Gypsum Fibrosum 11 weight portion, Radix et Rhizoma Dispori Cantoniensis 8 weight portion, Herba Asplenii Vaiainte Spleenwort 13 weight portion, Herba Bryophylli Pinnati 10 weight portion, Resina Liquidambaris 8 weight portion, propolis 7 weight portion and Folium et Ramulus Callicarpae nudiflorae 12 weight portion;
When the dosage form of external used medicine is ointment, its preparation method comprises the following steps: the crude drug getting the described ratio of weight and number except Resina Liquidambaris and propolis soaks 1 hour, then multi-function extractor is placed in, first time decocts 7 times that amount of water is medical material, decocts, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.05MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 65 DEG C, cooling; Add in extractum after Resina Liquidambaris and propolis are pulverized, tinning after ultraviolet radiation sterilizing.
 
Embodiment 4 liniment
Embodiments provide a kind of external used medicine being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type, wherein the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 20 weight portion, Xylocopa dissimilis (Lep.) 10 weight portion, Gypsum Fibrosum 8 weight portion, Radix et Rhizoma Dispori Cantoniensis 5 weight portion, Herba Asplenii Vaiainte Spleenwort 17 weight portion, Herba Bryophylli Pinnati 15 weight portion, Resina Liquidambaris 10 weight portion, propolis 10 weight portion and Folium et Ramulus Callicarpae nudiflorae 15 weight portion;
Its preparation method comprises the following steps:
Step one: first the described raw medicinal material except Resina Liquidambaris and propolis is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 9 times amount soak by water 2 hours, and second time adds weight portion 8 times amount soak by water 2 hours, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: Resina Liquidambaris and propolis powder are broken into powder, and call in glycerol after mixing with fine powder b with fine powder a and make liniment.
 
Toxicity test
One, apply NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 2 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.
Two, the capsule of the embodiment of the present invention 1 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Three, the ointment of the embodiment of the present invention 3 is carried out " acute dermal toxicity test " test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, ointment percutaneous of the embodiment of the present invention 3 is smeared 5000mg/kg body weight dose, observes 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Four, by the liniment of the embodiment of the present invention 4 according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, according to the method for above-mentioned " acute dermal toxicity test ", prepare coating, then getting 0.5g directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
 
Clinical trial
Case selection: fetch the 129 routine damp and hot poison coming from the court patient and accumulate the scorching patient of the acute lymphatic meshwork of type, man 75 example, female 54 example, age 28-71 year, lower limb 84 example, face 36 example, bottom partial trauma history 9 example, wherein recurrent exerbation person has 54 examples, 129 routine patients are divided into three groups at random, often organize 43 examples, be respectively treatment group 1, treatment group 2 and matched group, wherein each experimental group data statistical procedures there was no significant difference (P > 0.05) in age, sex, the state of an illness etc., has comparability.
Diagnostic criteria: shiver with cold suddenly during (1) acute attack, erythema, clear border appear in high heat, affected areas, be rapidly to spread expansion around, have scorching hot and gargalesthesia, edema or vesicle, inguinal lymph nodes can enlargement pain; (2) blood test numeration of leukocyte increases; (3) can recurrent exerbation; (4) serious then skin is hardening, and swelling is obvious, and even knot poisons pus or cutaneous necrosis, can accompany grade fever, infantile anorexia; Red tongue, yellow and greasy fur, slippery and rapid pulse.
Therapeutic Method:
Treatment group 1: use the capsule of the embodiment of the present invention 1 and the ointment of embodiment 3, capsule every day three times, each 2, ointment is directly applied in affected part, every day twice, continuously treatment 7-15 days;
Treatment group 2: use the tablet of the embodiment of the present invention 2 and the liniment of embodiment 4, tablet every day three times, each 2, liniment is directly applied in affected part, every day three to five times, continuously treatment 7-15 days;
Matched group: intramuscular injection or intravenous drip penicillin, every day 1-2 time, continuously treatment 7-15 days.
Criterion of therapeutical effect: with reference to " disease of tcm Standardization of diagnosis and curative effect ", recovery from illness: the resolution of symptoms such as the red and swollen causalgia of General Symptoms and local, blood leukocytes is normal, follows up a case by regular visits to half a year without recurrence; Take a turn for the better: General Symptoms disappears, the red and swollen causalgia in local obviously alleviates or disappears, and affected part swelling is still deposited, blood leukocytes sum and decline or normal; Invalid: though General Symptoms improves, the red and swollen causalgia of lower limb is not improved, or focus knot poisons pus.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt the damp and hot poison for the treatment of by Chinese herbs of the present invention to accumulate the acute lymphatic meshwork of type scorching, relative to Chinese patent medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt the damp and hot poison for the treatment of by Chinese herbs of the present invention to accumulate the acute lymphatic meshwork of type scorching, relative to Western medicine, treatment course for the treatment of significantly shortens.
Table 1 three components is not treated and is terminated rear Clinical efficacy comparison example
Group Number of cases Cure Take a turn for the better Invalid Cure rate Total effective rate
Treatment group 1 43 28 15 0 65.1% 100%
Treatment group 1 43 25 16 2 58.1% 95.3%
Matched group 43 15 19 9 34.9% 81.4%
Table 2 three components is not treated and is terminated rear healing number and time comparative example (%)
Group Number of cases 7-10 days 11-13 days 14-15 days
Treatment group 1 28 11(39.3%) 12(42.9%) 5(17.9%)
Treatment group 2 25 9(36.0%) 11(44.0%) 5(20.0%)
Matched group 15 3(20.0%) 5(33.3%) 7(46.7%)
According to the clinical statistics in above table, pharmaceutical composition provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to the follow-up of patients 1 year that treatment group is cured, result is added up, and 28 examples in treatment group 1, all without recurring; 25 examples in treatment group 2,1 example recurrence, relapse rate is 4%; Matched group 15 example, recurs 3 people, relapse rate 20%.
 
Model case
Neat certain, man, 51 years old, swell and ache inside right leg Pi Hong, clear-cut margin, oppress redness gently with finger can disappear, after decontroling, redness is recovered very soon, the scorching hot pain of local skin, continue 5 days, body temperature 38.4 DEG C, and with lymphadenectasis, headache, feel sick, the symptoms such as vomiting, through blood examination leukocytosis, be diagnosed as damp and hot poison according to Chinese medical discrimination analysis and accumulate the acute lymphatic meshwork inflammation of type, use the capsule of the embodiment of the present invention 1 and the ointment of embodiment 3, capsule every day three times, each 2, ointment is directly applied in affected part, every day twice, continuous treatment is almost recovered for 5 days, continual cure 3 days, recovery from illness, follow up a case by regular visits to and do not recur for 1 year.
 
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, described pharmaceutical composition comprises endo-medicine and external used medicine, and described endo-medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Herba Clinopodii Polycephali, Gypsum Fibrosum, Radix Berberidis Amurensis, Herba Commelinae, Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Portulacae, Herba Lobeliae Chinensis, Radix Rhapontici, Herba Euphorbiae Humifusae, Cortex Moutan, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Herba Aristolochiae, Herba desmodii microphylli, Radix Longan, Folium Pini, geranium, Cortex erythrinae, Radix Stephaniae Tetrandrae, Resina Liquidambaris, Radix Salviae Miltiorrhizae and Flos Rosae Chinensis;
Described external used medicine comprises following raw medicinal material: Radix Stephaniae Japonicae, Xylocopa dissimilis (Lep.), Gypsum Fibrosum, Radix et Rhizoma Dispori Cantoniensis, Herba Asplenii Vaiainte Spleenwort, Herba Bryophylli Pinnati, Resina Liquidambaris, propolis and Folium et Ramulus Callicarpae nudiflorae.
2. the pharmaceutical composition being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type according to claim 1, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 11-18 weight portion, Xylocopa dissimilis (Lep.) 10-15 weight portion, Herba Clinopodii Polycephali 8-15 weight portion, Gypsum Fibrosum 5-13 weight portion, Radix Berberidis Amurensis 7-12 weight portion, Herba Commelinae 12-18 weight portion, Radix Scutellariae 7-14 weight portion, Rhizoma Coptidis 15-19 weight portion, Radix Sophorae Flavescentis 6-12 weight portion, Herba Portulacae 4-8 weight portion, Herba Lobeliae Chinensis 9-18 weight portion, Radix Rhapontici 7-15 weight portion, Herba Euphorbiae Humifusae 5-17 weight portion, Cortex Moutan 9-20 weight portion, Radix Scrophulariae 7-15 weight portion, Radix Arnebiae (Radix Lithospermi) 7-18 weight portion, Cortex Magnoliae Officinalis 10-16 weight portion, Pericarpium Citri Reticulatae 10-20 weight portion, Rhizoma Atractylodis 11-18 weight portion, Herba Aristolochiae 9-13 weight portion, Herba desmodii microphylli 9-15 weight portion, Radix Longan 9-15 weight portion, Folium Pini 5-12 weight portion, geranium 8-15 weight portion, Cortex erythrinae 7-15 weight portion, Radix Stephaniae Tetrandrae 8-15 weight portion, Resina Liquidambaris 10-20 weight portion, Radix Salviae Miltiorrhizae 10-20 weight portion and Flos Rosae Chinensis 11-17 weight portion.
3. the pharmaceutical composition being used for the treatment of damp and hot poison and accumulateing the acute lymphatic meshwork inflammation of type according to claim 1 and 2, it is characterized in that, in described external used medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 15-20 weight portion, Xylocopa dissimilis (Lep.) 10-18 weight portion, Gypsum Fibrosum 8-15 weight portion, Radix et Rhizoma Dispori Cantoniensis 5-12 weight portion, Herba Asplenii Vaiainte Spleenwort 9-17 weight portion, Herba Bryophylli Pinnati 5-15 weight portion, Resina Liquidambaris 5-10 weight portion, propolis 5-10 weight portion and Folium et Ramulus Callicarpae nudiflorae 10-15 weight portion.
4. according to any one of claim 1-3, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 14 weight portion, Xylocopa dissimilis (Lep.) 12 weight portion, Herba Clinopodii Polycephali 11 weight portion, Gypsum Fibrosum 9 weight portion, Radix Berberidis Amurensis 9 weight portion, Herba Commelinae 15 weight portion, Radix Scutellariae 10 weight portion, Rhizoma Coptidis 17 weight portion, Radix Sophorae Flavescentis 9 weight portion, Herba Portulacae 6 weight portion, Herba Lobeliae Chinensis 13 weight portion, Radix Rhapontici 11 weight portion, Herba Euphorbiae Humifusae 11 weight portion, Cortex Moutan 14 weight portion, Radix Scrophulariae 11 weight portion, Radix Arnebiae (Radix Lithospermi) 13 weight portion, Cortex Magnoliae Officinalis 13 weight portion, Pericarpium Citri Reticulatae 15 weight portion, Rhizoma Atractylodis 14 weight portion, Herba Aristolochiae 11 weight portion, Herba desmodii microphylli 12 weight portion, Radix Longan 12 weight portion, Folium Pini 8 weight portion, geranium 11 weight portion, Cortex erythrinae 11 weight portion, Radix Stephaniae Tetrandrae 11 weight portion, Resina Liquidambaris 15 weight portion, Radix Salviae Miltiorrhizae 15 weight portion and Flos Rosae Chinensis 14 weight portion.
5. according to any one of claim 1-4, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, in described external used medicine, the parts by weight of each raw medicinal material are: Radix Stephaniae Japonicae 17 weight portion, Xylocopa dissimilis (Lep.) 14 weight portion, Gypsum Fibrosum 11 weight portion, Radix et Rhizoma Dispori Cantoniensis 8 weight portion, Herba Asplenii Vaiainte Spleenwort 13 weight portion, Herba Bryophylli Pinnati 10 weight portion, Resina Liquidambaris 8 weight portion, propolis 7 weight portion and Folium et Ramulus Callicarpae nudiflorae 12 weight portion.
6. according to any one of claim 1-5, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, the dosage form of described endo-medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
7. according to any one of claim 1-5, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
8. according to any one of claim 1-5, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, the dosage form of described external used medicine is ointment, its preparation method comprises the following steps: the crude drug getting the described ratio of weight and number except Resina Liquidambaris and propolis soaks 1-2 hour, then multi-function extractor is placed in, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling; Add in extractum after Resina Liquidambaris and propolis are pulverized, tinning after ultraviolet radiation sterilizing.
9. according to any one of claim 1-5, be used for the treatment of the pharmaceutical composition that damp and hot poison accumulates the acute lymphatic meshwork inflammation of type, it is characterized in that, the dosage form of described external used medicine is liniment, and its preparation method comprises the following steps:
Step one: first the described raw medicinal material except Resina Liquidambaris and propolis is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: Resina Liquidambaris and propolis powder are broken into powder, and call in glycerol after mixing with fine powder b with fine powder a and make liniment.
CN201410565892.XA 2014-10-22 2014-10-22 Scorching pharmaceutical composition of the acute lymphatic meshwork of type and preparation method thereof is accumulate for treating damp and hot poison Expired - Fee Related CN104257871B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106266372A (en) * 2016-09-12 2017-01-04 防城港思创信息技术有限公司 A kind of Chinese medicine pill for acute lymphangitis

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Publication number Priority date Publication date Assignee Title
CN1413615A (en) * 2002-03-15 2003-04-30 张肇域 Tongmailing pill and its preparation method
CN1853671A (en) * 2005-04-29 2006-11-01 张葆现 Thrombolytic collaterals-activating preparation for treating angiitis and phlebitis and making method thereof
CN103655907A (en) * 2012-09-18 2014-03-26 青岛医防消毒专业技术中心 Compound washing liquor for treating erysipelas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1413615A (en) * 2002-03-15 2003-04-30 张肇域 Tongmailing pill and its preparation method
CN1853671A (en) * 2005-04-29 2006-11-01 张葆现 Thrombolytic collaterals-activating preparation for treating angiitis and phlebitis and making method thereof
CN103655907A (en) * 2012-09-18 2014-03-26 青岛医防消毒专业技术中心 Compound washing liquor for treating erysipelas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106266372A (en) * 2016-09-12 2017-01-04 防城港思创信息技术有限公司 A kind of Chinese medicine pill for acute lymphangitis

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