CN103721191A

CN103721191A - Traditional Chinese medicinal enema for treating female chronic pelvic inflammation and preparation method thereof

Info

Publication number: CN103721191A
Application number: CN201310746378.1A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2013-12-30
Filing date: 2013-12-30
Publication date: 2014-04-16

Abstract

The invention discloses a traditional Chinese medicinal enema for treating female chronic pelvic inflammation. The enema is prepared from the following raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-20 parts of fructus rosae laevigatae, 10-20 parts of suberect spatholobus stem, 10-20 parts of akebiaquinata, 10-20 parts of plantain herb, 10-20 parts of oldenlandia diffusa, 10-20 parts of sargent gloryvine, 10-20 parts of raw rehmannia, 10-20 parts of albizia flower, 10-20 parts of salviae miltiorrhizae, 10-20 parts of honeysuckle, 10-20 parts of cortex phellodendri, 10-20 parts of fructus kochiae, 10-20 parts of Chinese angelica, 10-20 parts of fructus cnidii, 10-20 parts of coptidis rhizoma, 10-20 parts of purslane, 10-20 parts of raspberry, 10-20 parts of white peony root, 10-20 parts of radix curcumae, 10-20 parts of rhizoma bletillae, and 10-20 parts of sophora flavescens. The traditional Chinese medicinal enema can directly reach the focus, has the effects of activating blood circulation to remove stasis, and eliminating dampness and heat, is suitable for treatment of chronic pelvic inflammation, chronic annexitis, ovarian cyst, elytritis and other common diseases, is remarkable in effect, has the advantages of quick dissolution and quick drug release, and can achieve the aim of quickly relieving the symptom.

Description

A kind of Chinese medicinal enema for the treatment of women's chronic pelvic inflammatory disease and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicinal enema for the treatment of women's chronic pelvic inflammatory disease and preparation method thereof.

Background technology

Chronic pelvic inflammatory disease is often because of thoroughly treatment of acute pelvic inflammatory disease, or patient's body constitution is poor, due to protracted inflammation, belongs to Chinese medicine stomachache, leukorrhagia, Epileptic and levies the categories such as abdominal mass.Female pelvic inflammation refers to the internal genitalia inflammation of (comprising uterus, fallopian tube, the other connective tissue in palace and pelvic peritoneum), both can be confined to certain position of female body, also can relate to whole internal genitalia.If when pathological changes is only confined to fallopian tube and ovary, be commonly referred to adnexitis.According to the pathological development process of female pelvic inflammation, clinical two kinds of acute pelvic inflammatory disease and the chronic pelvic inflammatory diseases that are divided into, in motherland's medical science, this disease belongs to stomachache, invasion of the blood-chamber by heat, leukorrhagia, the category such as infertile.

The traditional Chinese medical science thinks, premenstrual puerperal, vessels of the uterus was hollow, and just open blood chamber, or Postoperative fatigue is weak, and damp and hot foul heresy invaded in taking advantage of a weak point in opponent's defence, and stops up in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, fights to tie in punching appoint a uterus with QI and blood, and stagnation of QI-blood, stops up and hold back not all rightly, blocks meridians, stagnation of QI and blood may bring about pain.Therefore occur hypogastralgia, lumbago, damp invasion of lower energizer is leucorrhoea grow in quantity, be characterized in wetting, the stasis of blood, heat be trouble.Therefore treatment adopts the administration of traditional Chinese medical science multipath, Coryza Treated by Syndrome Differentiation or heat-clearing and toxic substances removing, or dampness removing spleen invigorating, or soothing the liver regulating QI, or blood circulation promoting and blood stasis dispelling eliminating stagnation, strengthening vital QI to eliminate pathogenic factors, with card plus-minus.External application and coloclysis Chinese medicine all have the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Drug retention enema is a kind of method of extravascular administration, and medicine directly passes through rectum Absorption in inflammation part.Because medicine is heated to 40 ℃ of left and right, proper temperature plays physiotherapy function, can accelerate local blood circulation, impels hypertrophy fibrous tissue softening, is conducive to the dissipation of inflammation focus and absorbs.And prolonged and repeated use antibiotic produces drug resistance, side effect etc. and brings difficulty to treatment.

Chronic pelvic inflammatory disease main manifestations is lower abdomen falling inflation pain, waist thigh pain, sometimes uncomfortable with rectal tenesmus, after the fatigue of being everlasting, sexual intercourse, during defecation and before and after menstruation, increase the weight of, in addition, also may be with frequent micturition, leucorrhoea grow in quantity, irregular menstruation, dysmenorrhea and the symptom such as infertile.During gynaecological examination, if adnexitis can be in the one or both sides in uterus and increase thick streak thing or sheet block, and with tenderness; As formed hydrosalpinx or cyst of fallopian tube, can touch capsule enclosed mass; If inflammation of pelvic connective tissue, both sides, uterus can thicken and have tenderness in various degree in the form of sheets.

It is not thorough that chronic pelvic inflammatory disease mostly is acute pelvic inflammatory disease treatment, and patient meets flu, overwork etc. causes premunition low, and source of disease bacterium is active again causes pelvic inflammation recurrence, also has some patients were NAI history, because onset is slow, due to ignoring and treating.Its pathological change is inflammatory exudation in pelvic cavity, organ adhesion, local organization scar hyperplasia, and uterus maintains static.Pelvic congestion is menorrhagia, and ovarian function is damaged menoxenia, and fallopian tube adhesion is infertile, and hydrosalpinx is ovarian cyst.

There is survey data to show: in common gynaecopathia case, the overall sickness rate of chronic pelvic pain is 16.9%, and overall Pathogenesis is the highest with pelvic inflammatory disease, is 40.3%, in chronic pelvic inflammatory disease, fertility person's sickness rate is 33.1%, and nullipara's sickness rate is 56.7%.After obtaining, pelvic inflammatory disease can cause oviducal adhesion, logical and not smooth with regard to causing fallopian tube, or obstructed like this, so just cause infertility.Also have survey data to show: the course of disease is in the sterility and infertility patient of 1 year～13 years, sterility and infertility accounts for and checks abnormal person's 63.8% due to salpingitis.Therefore, pelvic inflammatory disease is one of common frdquently encountered disease disease affecting women's work, studying and living, how effectively to treat female pelvic inflammation tool and is of great significance.

Treatment female pelvic inflammation can be divided into western medical treatment and Chinese traditional treatment, and in Chinese traditional treatment, has extract oral, the external application of Chinese medicine, herbal enema, Chinese medicine drop, tcm herbal ion to import, and can also coordinate the several different methods such as acupuncture.Chronic pelvic inflammatory disease is a very important health problem, and women's fertility in future is had a strong impact on, and the result that can effectively treat chronic pelvic inflammatory disease depends on: early diagnose and early treatment, depend on the application of effective medicine simultaneously.A kind of frequently-occurring disease of Zhe Shi gynecological, commonly encountered diseases, and the medicine for the treatment of is a lot of both at home and abroad at present, but unsatisfactory curative effect.At present, doctor trained in Western medicine there is no method and obtains desirable curative effect, particularly poorer to pelvic tissue adhesion and perilesional connective tissue parcel severe patient curative effect.The Chinese medicine of this disease for the treatment of is mainly enema and enema at present, if but the subjective symptoms of these drug main reduction of patient is improved not good to patient's local sign and focus pathological change.

Summary of the invention

Technical problem to be solved by this invention is, chronic pelvic inflammatory disease gynecological is a kind of frequently-occurring disease, commonly encountered diseases, and the medicine for the treatment of is a lot of both at home and abroad at present, but unsatisfactory curative effect.At present, doctor trained in Western medicine there is no method and obtains desirable curative effect, particularly poorer to pelvic tissue adhesion and perilesional connective tissue parcel severe patient curative effect.The Chinese medicine of this disease for the treatment of much adopts suppository, enema at present, if but the subjective symptoms of these drug main reduction of patient is improved not good to patient's local sign and focus pathological change.The present invention in conjunction with clinical experience for many years, adopts modern processing method meticulously to develop on the basis of traditional medicine.The present invention's each effective ingredient science compatibility to raw material medicine, the focus of going directly, and instant effect, side effect is little, biocidal property is strong preparation, can efficient solution except patient's misery, reach the object of dispelling disease.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicinal enema for the treatment of women's chronic pelvic inflammatory disease, in described Chinese medicinal enema, the parts by weight of various raw materials are: 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Caulis Spatholobis, 10～20 parts of Caulis Akebiaes, 10～20 parts of Herba Plantaginiss, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Flos Albiziaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Flos Loniceraes, 10～20 parts of Cortex Phellodendris, 10～20 parts of the Fructus Kochiae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Cnidiis, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Herba Portulacaes, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Curcumaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Sophorae Flavescentiss.

The Chinese medicinal enema of described treatment women's chronic pelvic inflammatory disease, described in it, in Chinese medicinal enema, the parts by weight of various raw materials can be: 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Fructus Rosae Laevigatae, 10～15 parts of Caulis Spatholobis, 10～15 parts of Caulis Akebiaes, 10～15 parts of Herba Plantaginiss, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Caulis Sargentodoxaes, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Flos Albiziaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Flos Loniceraes, 10～20 parts of Cortex Phellodendris, 10～20 parts of the Fructus Kochiae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Cnidiis, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Herba Portulacaes, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Curcumaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Sophorae Flavescentiss.

The Chinese medicinal enema of described treatment women's chronic pelvic inflammatory disease, described in it, in Chinese medicinal enema, the parts by weight of various raw materials can also be: 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Caulis Spatholobis, 10～20 parts of Caulis Akebiaes, 10～20 parts of Herba Plantaginiss, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Flos Albiziaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Flos Loniceraes, 10～15 parts of Cortex Phellodendris, 10～15 parts of the Fructus Kochiae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Cnidiis, 10～15 parts of Rhizoma Coptidis, 10～15 parts of Herba Portulacaes, 10～15 parts of Fructus Rubies, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Radix Curcumaes, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Sophorae Flavescentiss.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicinal enema of described treatment women's chronic pelvic inflammatory disease, and the preparation process of described enema comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes are merged into enema.

In described step a, can get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 1.

In described step b, the medicinal residues that ethanol extraction can be crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.

In described step c, above-mentioned two kinds of component paste concentrated solutions can be merged, then use ultraviolet ray sterilization bactericidal, become enema.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Chinese medicinal enema of described treatment women's chronic pelvic inflammatory disease again, and the preparation process of described enema further comprises:

A. described crude drug is put into except Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis to pulverizer grinding and sieving,

B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis are distilled to the crystallization of vaporizing to obtain, add in above-mentioned two kinds of extracting solution, be condensed into pasty state, after ultraviolet virus killing, use.

In described step a, described crude drug can be put into except Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis after pulverizer is pulverized and be crossed 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves standby; In described step b, particulate matter remaining after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution be merged standing;

In described step c, the medicinal residues that above-mentioned ethanol extraction can be crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; In described steps d, the crystallization of Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis distillation can being vaporized to obtain, is dried to powder; Above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaims ethanol again, gained filtrate is adjusted to proportion to 1.60, after adding the crystalline powder of the fine powder that sieves and distillation, stir evenly, 100-120 order filters, and after ultraviolet virus killing, uses.

The using method of enema of the present invention: choose crude drug, can prepare enema by the method that the invention provides embodiment, also available clear water 500ml decocts as medicine soup 150-120ml, get supernatant cool to medicine temperature for 30-40 ℃ of left and right, after advising patient's defecation, get lateral position, with anal canal, insert the about 20cm of anus, with 50ml syringe, inhale medicinal liquid and slowly from anal canal, pour into (or using transfusion device infusion) capable retention enema of rectum, after coloclysis, slightly padded buttocks is flat sleeping 30 minutes, every day, coloclysis was 1 time, and treating 10 days was 1 course for the treatment of.During per rectum administration, medicine can absorb 50%-70% at rectum, and by liver, does not directly enter 3 Venous systems of pelvic cavity viscera, makes pelvic inflammation rehabilitation rapidly under medicine effective concentration effect.

The advantages such as compared with prior art, this technology has convenient drug administration, and medicament is easy to manufacture, and the focus of going directly, with low cost.The present invention has blood circulation promoting and blood stasis dispelling, eliminating damp-heat, itch-stopping bactericidal, and lenitive effect, for chronic pelvic inflammatory disease, disease is seen profuse leukorrhea, the diseases such as hypogastralgia are applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis simultaneously, and effect is remarkable.This enema has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.Can create good social value and economic interests.

The specific embodiment

Pelvic inflammatory disease is common gynecological disease, comprises the inflammation of pelvic cavity genitals (corpus, fallopian tube, ovary) and pelvic peritoneum and periuterine connective tissue.Multiple the being born in property active phase of pelvic inflammatory disease women, 21-30 year is pelvic inflammatory disease age bracket occurred frequently.Motherland's medical science thinks that this disease is many by hollow through row vessels of the uterus in puerperal, invades uterus in affection of exogenous damp pyretic toxicity; Or the spleen damage of suffering from a deficiency of the kidney, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, the uterus of making a bet; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, causes pelvic cavity viscera inner membrance QI-blood circulation not smooth, and damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Because mistake is controlled or wrong treatment, cause outbreak repeatedly, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.This disease simulataneous insufficiency and excessive, the wet hot phlegm stasis of blood are suffered from mutually each other, and spleen is suffered from a deficiency of the kidney and damaged is it, and wet hot phlegm stasis blocking is stagnant is its mark.

Chronic pelvic inflammatory disease comprises chronic adnexitis and chronic pelvic paramitritis.The former often shows as tubal wall and thickens hardening, and mucous layer has inflammatory exudate, and fallopian tube sticks together, and tube chamber is blocked, even ovary get involved simultaneously and with fallopian tube break-through, form tubo-ovarian cyst or abscess.Latter is failed thoroughly to cure because of acute inflammation and is developed into chronicly, because tissue is congested, edema, then occurs again proliferation of fibrous tissue, hardening, its inflammation also may be the fan-shaped through pelvic cavity of external diffusion that resembles, therefore uterus is often fixed, and this chronic inflammatory disease state of an illness is obstinate, is difficult for radical cure.

Pelvic inflammatory disease, is equivalent in the disease categories such as " leukorrheal diseases ", " menoxenia " in motherland's medical science, " dysmenorrhea ", " lump in the abdomen ".The pathogenic factor of this disease mostly is after childbirth, miscarriage, gynecilogical operation or menstruation, and blood sinus is open, and careless to some extent, damp and hot evil poison is taken advantage of a weak point, if excess of pathogen healthy energy is also contained, the state of an illness oncoming force is more violent, if evil Sheng is weakened body resistance, acute inflammation situation is very unobvious.How because of mistake, to control wrong treatment and transfer chronic phase to.Clinical the most common with chronic pelvic inflammatory disease person.It is stagnant at uterus, vessels of the uterus that its pathogenesis is turbid damp, damp and hot, the evil poison of cold-damp pents up the stasis of blood, so that meridians impatency is obstructed, functional activity of QI being not smooth, and coagulation of QI-blood forms.Thereby acute stage will be with heavy dose of heat-clearing and toxic substances removing, the agent of dampness removing blood circulation promoting and blood stasis dispelling.Chronic phase is to be delayed by acute stage, because with the passing of time meridian stasis stagnant, so will be with blood circulation promoting and blood stasis dispelling, heat clearing away, dampness removing are main, drink the product that add QI invigorating, also will differentiate the character of turbid damp, add neatly the medicine of invigorating spleen to remove dampness or heat-clearing and toxic substances removing, warming YANG removing dampness, can not stick to routine.Therefore should tonifying speen and tonifying kidney eliminate the phlegm wet, heat-clearing and toxic substances removing is soothing the liver, blood circulation promoting and blood stasis dispelling eliminating stagnation is basic therapy.

Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, has the touching feature that does not heal, is easy to recurrence, is a great problem in domestic and international gyniatrics.It is not thorough that chronic pelvic inflammatory disease mostly is acute pelvic inflammatory disease treatment, and patient meets flu, overwork etc. causes premunition low, and source of disease bacterium is active again causes pelvic inflammation recurrence, also has some patients were NAI history, because onset is slow, due to ignoring and treating.Its pathological change is inflammatory exudation in pelvic cavity, organ adhesion, local organization scar hyperplasia, and uterus maintains static.Pelvic congestion is menorrhagia, and ovarian function is damaged menoxenia, and fallopian tube adhesion is infertile, and hydrosalpinx is ovarian cyst.

Motherland's medical science thinks that this disease is many by hollow through row vessels of the uterus in puerperal, invades uterus in affection of exogenous damp pyretic toxicity; Or the spleen damage of suffering from a deficiency of the kidney, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, the uterus of making a bet; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, causes pelvic cavity viscera inner membrance QI-blood circulation not smooth, and damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Because mistake is controlled or wrong treatment, cause outbreak repeatedly, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.This disease simulataneous insufficiency and excessive, the wet hot phlegm stasis of blood are suffered from mutually each other, and spleen is suffered from a deficiency of the kidney and damaged is it, and wet hot phlegm stasis blocking is stagnant is its mark.

Object of the present invention, is exactly all undesirable for the curative effect of the medicine of pelvic inflammatory disease in gynaecopathia, takes effect slower, large to human body side effect, larger to body of women harm, and easy shortcoming repeatedly, a kind of instant effect of invention production, the medicine that side effect is little, biocidal property is strong, to remove patient's misery.

Preparation technology of the present invention is simple, and medicine material is cheap, and good effect can reach reasonable social effect and economic interests.The present invention has the effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, the pelvic inflammatory disease of penting up for the stagnation of QI, and the disease such as disease is seen profuse leukorrhea, hypogastralgia is applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis simultaneously, and effect is remarkable.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.According to the theory of the traditional Chinese medical science " many empty, the many stasis of bloods of prolonged illness of prolonged illness ", treatment be take strengthening vital QI to eliminate pathogenic factors as principle, the good recipe of the tangible various inflammation such as dysmenorrhes leukorrhagia, pelvic cavity, vagina, adnexa for the treatment of.

Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Rhizoma Atractylodis have drying damp and strengthening spleen, the effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia.< < pearl sac > > day: " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove." < < Compendium of Materia Medica > > says: " control damp-phlegm prolonged fluid-retention ... and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down." < < Newly Revised Canon of Materia Medica > > claims that it can " diuresis ".

Fructus Rosae Laevigatae: Latin formal name used at school Cherokee Rose.For the dry mature fruit of rosaceous plant Fructus Rosae Laevigatae Rosa laevigata Michx. is sour, sweet, puckery, flat.Return kidney, bladder, large intestine channel.Controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.In Fructus Rosae Laevigatae, contain a large amount of acidic materials, soap one-tenth etc., can controlling nocturnal emission with astringent drugs chamber prevent that pass out semen lingering diarrhea, woman's leukorrhagia of man is too much, again can astringing intestine to stop diarrhea road, prevent the dysentery of insufficiency of the spleen constraint due to ineffective.Recent study finds, Fructus Rosae Laevigatae extracting solution can kill staphylococcus aureus and escherichia coli etc., can be used to treat Yin Jin Portugal bacterium or coli-infection and the disease that causes

Caulis Akebiae nature and flavor are bitter, cool.Pathogenic fire purging row water.Promoting blood circulation.Cure mainly hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Interior without damp and hot, body fluid deficiency, a little less than gas, essence is sliding.Clearing away heat and promoting diuresis; Blood circulation and channel invigorating.Main red urine is red; Stranguria with turbid discharge; Edema; Irritable feverish sensation in the chest; Larynx larynx pain; Aphtha of the mouth and tongue; Rheumatic arthralgia; Galactostasis; Amenorrhea; Dysmenorrhea.< < herbal classic > >: master goes to dislike worm, except taste cold and heat, tonneau nine orifices blood vessels joint, makes us not forgetting.< < does not record > >: treat spleen subcutaneous ulcer Chang Yumian, the vexed sound of vomiting, goes out speech, treat deafly, the loose all knots of carbuncle do not disappear, and incised wound, malignant boil, scrofula, Wei folding, nasal polyp, induced abortion, goes three worms.

Herba Hedyotidis Diffusae is again Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature removing toxic substances, sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Be generally used for treatment sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also for the puckery pain of pyretic stranguria, dysuria.The good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.

(formal name used at school: Sargentodoxa cuneata) rhizome is pharmaceutically acceptable, has dredge the meridian passage, eliminating stasis to stop pain, an effect such as the promoting the circulation of blood of regulating the flow of vital energy, parasite killing to Caulis Sargentodoxae, cures mainly rheumatalgia, traumatic injury, dysmenorrhea, amenorrhea, ascarid.Also can do veterinary's medication, effective in cure to oxen and horses mistake food supply retail shop Hirudo associated diseases.Caulis Sargentodoxae is the rattan of plants of Lardizabalaceae Caulis Sargentodoxae.Bitter in the mouth, property is flat.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency.Cure mainly acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.Plate method test for bacteriostasis, 25% decoct has extremely responsive bacteriostasis to staphylococcus aureus, group B streptococcus, and escherichia coli, bacillus pyocyaneus, alpha streptococcus, micrococcus catarrhalis, Staphylococcus albus are all had to high responsive bacteriostasis.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.With respect to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.

Flos Albiziae contains Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for irritability, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.Also there is clearing away summer-heat, the face-beautifying and spot-removing effect such as relieve the effect of alcohol.< < book on Chinese herbal medicine is said through > >: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to anemia of pregnant woman, have preferably keep fit, calm, the effect of calming the nerves, improve looks, be also to treat neurasthenic good merchantable brand.

Flos Lonicerae: < < Compendium of Materia Medica > > carries " Flos Lonicerae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong, in surgery, is conventional product, is generally used for the sore and toxic of red and swollen heat pain.

Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.< < Chinese Pharmacopoeia > > carries the power of Cortex Phellodendri heat clearing and damp drying, similar to Radix Scutellariae, Rhizoma Coptidis, but take damp and hot as good except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.

Rhizoma Coptidis Rhizoma Coptidis is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.For cold and heat, tie mutually damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.The similarities and differences of Rhizoma Coptidis and Radix Scutellariae is: Rhizoma Coptidis is partial to into the heart, is longer than Qinghuo Jiedu, and property is dry, is the agent of heart stomach, cure mainly vexation, the double epigastric oppression of controlling, diarrhea, can adjust the thick intestinal of stomach, control dampness heat-dissipating, only quench one's thirst, separate Fructus Crotonis poison, arrogate to oneself except extreme misery mutually unrest disease and spread and flood card of a specified duration.Radix Scutellariae is not longer than clearing away lung-heat, dry though its property is cold, to control heat cloudy raw wet, cures mainly dysphoria with smothery sensation and bleeder, and that controls that gas heat attacks blood goes out blood disorder and little angina abdominis or abdominal pain in children, can be antiabortive and control and scald acute scleritis etc.Rhizoma Coptidis and Radix Scutellariae, similar temperament and respectively have speciality, therefore two medicine compatibilities more can be brought into play synergism, and the damp and hot benefit in Qinghua is aobvious.

The Radix Curcumae resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.The resolving depression of regulating the flow of vital energy: for the breast side of body and the stomach abdominal distention and pain of depression of liver-QI.< < detailed outline > > carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers, separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.For hemoptysis, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.< < Sheng Nong's herbal classic > >: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; < < Compendium of Materia Medica > >: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.< < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls, stops metrorrhagia dysentery, regulating menstruation arteries and veins.

Caulis Sargentodoxae bitter in the mouth is flat, enters large intestine channel.Function heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, wind dispelling insecticide.For abdominalgia with intestinal abscess, rheumatic arthralgia, traumatic pain, dysmenorrhes, bloody dysentery, stranguria with blood, infantile malnutrition worm is waited disease bitterly.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, < < A Supplement to the Compendium of Materia Medica > > carries it and can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis is gynecological external use good medicine.< < Bencao Jingshu > > carries: Fructus Cnidii, and bitter in the mouth is flat; It is pungent sweet nontoxic that < < does not record > >; Modern its abnormal smells from the patient in detail, when the warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil.< < does not record > > warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet can strengthening the spleen, therefore can be except all deficiency and coldness of married woman man disease of viscera connecting with this channel that wets.Cold-damp was both removed, and disease is gone, performance Yiyang, thus disease, and have tonification also.

The Fructus Kochiae is cold in nature, acrid in the mouth, hardship.Energy clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For diseases such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.< < key medicine divides agent > > to carry: " enter kidney, bladder two warps.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.

Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote the severe that of prostate secretion to cover.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Observation index is made in vaginal smear and inner membrance section with rat, rabbit, and Fructus Rubi seemingly has estrogen-like effects.The flat board method that burrows for bacteriostasis 100% decoct, has inhibitory action to staphylococcus, and vibrio cholera is also had to inhibitory action.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, QI invigorating, the hot disease of it row, pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment colpitis mycotica, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.

Its sweet in the mouth of Radix Angelicae Sinensis and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Herba Portulacae pyretic toxicity dysentery, enteritis, carbuncle sore tumefacting virus, snake bite and insect sting.Nature and flavor acid; Cold in nature.Gui Jing: large intestine; Liver Channel.Heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.Herba Portulacae has stronger inhibitory action to dysentery bacterium, Bacillus typhi and escherichia coli, can be used for the auxiliary treatment of various inflammation, have the title of " natural antibiotics ".< < Kaibao Bencao > >: " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.The raw juice clothes of smashing are disliked thing under profit, remove tapeworm." < < Compendium of Materia Medica > >: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.”

Herba Plantaginis is promoting diuresis to eliminate damp pathogen Chinese medicine, cures mainly: main dysuria, stranguria with turbid discharge leukorrhagia, edema distension, heat-damp in summer dysentery, conjunctival congestion are hidden from view, expectorant heat syndrome cough is breathed heavily.The < < property of medicine > > that falls: can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart.Semen Plantaginis, row liver is dredged kidney, smooth strongly fragrant and positive, with kidney-reinforcing drug use, makes reinforcing YIN-essence have son; Medicinal with regulating liver-QI, control conjunctival congestion blurred vision; With antipyretic use, dysentery relieving disease fire stagnation; With relaxing muscles and tendons is medicinal can promoting diuresis to eliminate dampness and promoting QI circulation, the sufficient knee joint of strong fortune, has testing also that speed answers.If feelings are moving, celebrate a festival, bladder is empty, and gas is difficult in change and Tianjin is not all right, the person that can drowns, and alone Herba Plantaginis catharsis, closes more, must add ginseng, Siberian cocklebur, sweet, wheat, the controlling desire of fostering the spirit of nobility, and voluntarily, excessive is also in Tianjin.

The preparation process of enema of the present invention is: get Rhizoma Atractylodis 1000g, Fructus Rosae Laevigatae 1000g, Caulis Spatholobi 1000g, Caulis Akebiae 1000g, Herba Plantaginis 1000g, Herba Hedyotidis Diffusae 1000g, Caulis Sargentodoxae 1000g, Radix Rehmanniae 1000g, Flos Albiziae 1000g, Radix Salviae Miltiorrhizae 1000g, Flos Lonicerae 1000g, Cortex Phellodendri 1000g, Fructus Kochiae 1000g, Radix Angelicae Sinensis 1000g, Fructus Cnidii 1000g, Rhizoma Coptidis 1000g, Herba Portulacae 1000g, Fructus Rubi 1000g, Radix Paeoniae Alba 1000g, Radix Curcumae 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Sophorae Flavescentis 1000g.Get in the ethanol that raw material adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid,, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 1.The medicinal residues that ethanol extraction is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, stand for standby use, becomes component 2.Above-mentioned two kinds of component paste concentrated solutions are merged, then use ultraviolet ray sterilization bactericidal, become enema.

The preparation process of enema of the present invention can also be: get Fructus Rosae Laevigatae 1500g, Caulis Spatholobi 1500g, Caulis Akebiae 1500g, Herba Plantaginis 1500g, Herba Hedyotidis Diffusae 1500g, Caulis Sargentodoxae 1500g, Radix Rehmanniae 1500g, Flos Albiziae 1500g, Radix Salviae Miltiorrhizae 1500g, Flos Lonicerae 1500g, Cortex Phellodendri 1000g, Fructus Kochiae 1000g, Radix Angelicae Sinensis 1000g, Fructus Cnidii 1000g, Rhizoma Coptidis 1000g, Herba Portulacae 1000g, Fructus Rubi 1000g, Radix Paeoniae Alba 1000g, Radix Sophorae Flavescentis 1000g.Soak 30 minutes to 1 hour, heated and boiled 30～40 minutes, filters filtrate for later use; Filtering residue adds water, and heating, boils 30～40 minutes for the second time, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into paste, then Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Rhizoma Atractylodis 1500g and Radix Curcumae 1000g are extracted with steam distillation, obtains crystal, is mixed in ointment obtained above; Stirring in water bath is even, is mixed into the liquid of thickness, after ultraviolet radiation for sterilizing and disinfecting, uses.

The preparation process of enema of the present invention can be also: get Fructus Rosae Laevigatae 1500g, Caulis Spatholobi 1500g, Caulis Akebiae 1500g, Herba Plantaginis 1500g, Herba Hedyotidis Diffusae 1500g, Caulis Sargentodoxae 1500g, Radix Rehmanniae 1500g, Flos Albiziae 1500g, Radix Salviae Miltiorrhizae 1500g, Flos Lonicerae 1500g, Cortex Phellodendri 1500g, Fructus Kochiae 1500g, Radix Angelicae Sinensis 1500g, Fructus Cnidii 1500g, Rhizoma Coptidis 1500g, Herba Portulacae 1500g, Fructus Rubi 1500g, Radix Paeoniae Alba 1500g, Radix Sophorae Flavescentis 1500g, by described crude drug, put into after pulverizer is pulverized and cross 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collect by the raw material fine powder of 100 mesh sieves standby.Particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; The medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Rhizoma Atractylodis 1500g and Radix Curcumae 1500g extract with steam distillation, are dried to powder; Again above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, 100-120 order filters, and after ultraviolet radiation for sterilizing and disinfecting, can use.

Toxicology test:

Pharmacology's toxicity test

One, antibacterial experiment

In body, antibacterial tests result shows, enema of the present invention has significant protective effect to the animal of escherichia coli and Bacillus proteus, can subtract the development of the state of an illness, reduces the mortality rate of animal; In-vitro antibacterial experimental result shows, prostatitis urinary system bolt has antibacterial and bactericidal action in various degree to the antibacterial of urinary system infection; The prostatitic experimental result that affects of experimental rat is shown, the present invention can infect the weightening finish of urinary system body of gland afterwards by anti-bacteria, slows down the development of the state of an illness, and the pathomorphism that suppresses prostata tissue changes; After administration, within 2-5 hour, can make the urine amount of animal obviously increase; Obvious cooling effect in 5 hours after the rabbit body temperature rising administration that fresh yeast is caused; The animal auricular concha swelling that xylol causes and granuloma induced by implantation of cotton pellets tissue is had to obvious inhibitory action, and suppress the increase of capillary permeability; The pain that chemical substance stimulating animal peritoneum or thermal stimulus animal body surface are caused has certain inhibitory action.

Result of the test shows: Chinese medicinal enema experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, the time of killing during to 1: 20 dilution factor is 5 minutes, it within 1: 50 o'clock, is 10 minutes, within 1: 100 o'clock, being 20 minutes, 1: 200 o'clock is 40 minutes, within 1: 400 o'clock, is 8 hours.

Two, animal acute toxicity test research:

When the present invention adopts rectally approach, the maximum dosage-feeding on the one that records mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about and intends 1567.5 times of clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.When experiment finishes, animal is healthy survival all, and body weight increases.

Three, long-term toxicity test for animals research:

It is high that medicine of the present invention is established in this test, in, low dose group and substrate matched group, blank group, adopt rectally approach to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character and the comparison of blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference be remarkable (P > 0.05) not, hematology and the indivedual indexs of blood parameters check result administration group and blank group comparing difference be (P < 0.05) significantly, but convalescent period finishes rear discrepant hematology and blood parameters has all recovered normal, other indexs and blank comparing difference be remarkable (P > 0.05) not, administration phase and convalescent period histological examination high dose group animal main organs and blank group relatively have no notable difference, having no slowness toxicity occurs.

Four, animal local excitation test:

The allergic reaction on guinea pigs of enema of the present invention and Rat-rectum medication irritation test.

Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to respectively to intend 20 times, 2.5 times of clinical people's consumption [0.04g (medicated powder)/kg], through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to respectively to intend 125,80 times of clinical people's consumption, in official hour, observe mucous membrane of rectum all without phenomenons such as hyperemia, edema, histopathologic examination and blank group be no significant difference relatively, have no and occur obvious irritative response, every group of its overall health of patients of Some Animals of retaining, body weight, breathing, circulation, central nervous system and extremity activity etc., all Non Apparent Abnormality reactions.

Five, vaginal mucomembranous irritant test result

1. test method:

Laboratory animal quarantine, after 3 days, is selected 18 above-mentioned healthy rabbits, is divided at random three groups, every group each 6, is respectively: blank, excipient contrast, enema group of the present invention (by 5 times of concentration of application liquid).With suitably big or small sterilizing cotton sliver, soak with sterile saline and tested material and be placed in excipient respectively

Matched group and the intravaginal of tested material treated animal, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Take out local vagina tissue, observe pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Pharmacodynamics test

Intestinal adhesion clinical manifestation is with knowing that block up disease conforms to, and as abdominal mass, abdomen localized pain is also shown in hemorheology variation etc.Therefore can manually manufacture animal intestine adhesion as Blood stasis pathological model.

Experimental technique: get some, body weight is 300 ± 20 grams of female rat, be placed in and be full of after the interior anesthesia of ether gas container, abdominal part cropping, sterilization, at aseptic condition menisectomy, along abdomen median line, longitudinally cut 3～4cm otch, find after vermiform appendix, apart from vermiform appendix cecum 0.5cm place, do the long stringer holostrome mouth of a 2.0～2.5cm, the feces of vermiform appendix intracavity is all removed totally with aseptic absorbent cotton, then by No. 1 fine and close (notching edge ploughs under vermiform appendix intracavity completely), the two-layer pass abdomen sewed up of silk thread for otch.And rat after operation is divided into 5 groups at random, be respectively enema of the present invention (shown in embodiment 1, method makes) 10g/kg, 5g/kg group, DANER FUKANG JIANGAO agent (Kuning Dianhong Pharmaceutical Co., Ltd.'s development) 10g/kg group, the scorching clean group of 30g/kg group of woman and model group 30ml/kg ordinary water.Hands second day after operation, each group is anus intraperitoneal administration respectively, every day 1 time, continuous 7 days.The 8th day by sacrifice of animal, cuts open the belly, and observes intestinal adhesion degree, adhesion incidence rate and average adhesion place number.Adhesion grading standard is as follows: "+" single place's adhesion, matter is crisp, cannot label taking this; " ++ " single place's adhesion, firmly, easily label taking is originally; " +++ " two places adhesion, firmly, easily label taking is originally; " ++++" the above adhesion in three places, firmly, easily label taking is originally.Experimental result sees the following form:

Note: compare ※ ※ p < 0.01 with model

Upper table result shows, adopts said method can cause intestinal adhesion model (intestinal adhesion all occurs model).Each administration group adhesion number of cases, compares with model group, and through X2 check, the high agent 10g/kg group of the present invention and DANER FUKANG JIANGAO agent group all have obvious diversity (P < 0.01), and all the other two groups of effects are not obvious.From adhesion degree, observe, each administration group forms adhesion, the adhesion degree of large intestine also than model group be gently (because of each administration group number of cases very little, cannot statistical disposition).From average adhesion number, each administration group is all few according to model group.Above-mentioned experimental result shows, enema of the present invention has certain anti-experimental character intestinal adhesion effect.

Test 2. In vitro Bactericidal Experiments

Culture medium: broth bouillon, broth agar culture medium, blood plate, chocolate flat board; Strain: select the strains such as escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, gonococcus, γ-streptococcus, micrococcus catarrhalis; Method: dilution method, by the high, medium and low dosage of enema solution of the present invention with meat soup from 1: 5,1:50 to 1: 100 make doubling dilution, every pipe is containing medicinal liquid 2ml, the 9th pipe, for without medicine contrast, adds 1 of dilution bacterium liquid in every pipe, hatch 18h for 37 ℃, perusal result, pastille least concentration is still the minimal inhibitory concentration (MIC) that obvious haze-free pipe is this medicine.Gonococcus is undergrowth in meat soup, uses chocolate plate dilution method instead and surveys minimal inhibitory concentration.As following table:

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Candida albicans	4.135
Gonococcus	11.8
		γ-streptococcus	27
Bacillus pyocyaneus	5.95
		Escherichia coli	51
Micrococcus catarrhalis	23
		Staphylococcus aureus	6.18

Result shows that the present invention is all 5mg/ml to the minimal inhibitory concentration of escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, and gonococcus is 10mg/ml.Escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, gonococcus are all had to obvious bacteriostasis.

3, antiinflammatory action test

Medicament selection: experimental group is enema of the present invention (embodiment method is obtained), matched group is first nitre file sheet, commercially available.Experimental animal: SD rat.

Inhibitory action to rat pedal swelling due to Ovum Gallus domesticus album: select experiment with rat, 220～300g, half and half, 10/group of male and female, left ankle subcutaneous injection 100% egg clear liquid 0.03ml/ only causes inflammation.After 1h, 2h, 4h, 6h, respectively measure joint girth one time.Obtaining each times two joints of foot girth poor is swelling, and amalgamation result, carries out the comparison of inflammation suppression ratio between each group.As following table:

Result shows that (high dose) of the present invention has the inhibitory action of highly significant to rat paw edema.To sum up result shows, enema of the present invention has obvious antiinflammatory action.

By above-mentioned pharmacodynamics test, confirmed that enema of the present invention all has obvious bacteriostasis to escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, gonococcus; Topical has resist inflammation on repercussive function to Ovum Gallus domesticus album rat paw edema.

Clinical trial:

My institute taked traditional Chinese medical science enema administration Comprehensive Treatment chronic pelvic inflammatory disease good results in recent years, existing that report the test is as follows:

1, data and method

1.1 physical data: case derives from my institute in January, 2009-2012 year December Out-patient Clinic of Department of Gynecology and inpatient, totally 120 examples.The diagnostic criteria of chronic pelvic inflammatory disease and differential diagnosis in tcm standard are divided damp-heat accumulation type; Stagnation of QI due to depression of the liver, hematogenous blockage type; Blood-stasis internal-depression, collaterals of the uterus is flow-through not; Asthenia of both the spleen and kidney, blood stagnancy due to deficiency of QI type.Be divided at random two groups, treatment group 60 examples, 18～54 years old age, the course of disease 6 months-11 years, lower abdominal pain 56 examples, lumbago 48 examples, leucorrhoea grow in quantity 38 examples.Matched group 60 examples, 20～55 years old age, the course of disease 6 months～11 years, lower abdominal pain 58 examples, lumbago 52 examples, leucorrhoea grow in quantity 42 examples, two groups of gynecologial examinations are uterus, adnexa tenderness, and uterine activity degree is limited, adnexa thickens etc., the data such as two groups of ages, the course of disease state of an illness are learned processing by statistics, and there are no significant for difference (P>0.05), has comparability.

1.1 Therapeutic Method

1.2.1 matched group: adopt antibiotic therapy to add herbal retention enema.Penicillin 3,200,000 u for antibiotic, add in 0.9%NS100ml (having penicillin skin test positive to use ofloxacin instead) intravenous drip, every day 2 times; 0.5% metronidazole injection 100ml intravenous drip, every day 2 times.Within 7 days, be 1 course for the treatment of, treat 2～3 courses for the treatment of.Another 10 days is 1 course for the treatment of with Chinese medicine pelvic inflammatory disease coloclysis side (the same treatment group of prescription and usage) retention enema, uses continuously 3 courses for the treatment of, and stop using menstrual period.

1.2.2 treatment group: adopt Chinese medicine retention enema.Within 10 days, be 1 course for the treatment of, treat altogether 3 courses for the treatment of, stop using menstrual period.

1.2.3 herbal retention enema is write out a prescription: Rhizoma Atractylodis 12g, Fructus Rosae Laevigatae 13g, Caulis Spatholobi 13g, Caulis Akebiae 13g, Herba Plantaginis 12g, Herba Hedyotidis Diffusae 11g, Caulis Sargentodoxae 13g, Radix Rehmanniae 13g, Flos Albiziae 12g, Radix Salviae Miltiorrhizae 13g, Flos Lonicerae 13g, Cortex Phellodendri 13g, Fructus Kochiae 13g, Radix Angelicae Sinensis 13g, Fructus Cnidii 13g, Rhizoma Coptidis 14g, Herba Portulacae 13g, Fructus Rubi 13g, Radix Paeoniae Alba 14g, Radix Curcumae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Radix Sophorae Flavescentis 13g.By the method for the invention, prepare enema or medicine-feeding and add that water is dense to be decocted, extracting juice 80ml, while being cooled to 38～39 ℃, advises the emptying stool of patient, left lateral position, and more than No. 5 hose inserts anus 10～15cm retention enema 1h, every day 1 time.Within 10 days, be 1 course for the treatment of, be used in conjunction 3 courses for the treatment of.

1.3 curative effect determinate standards: formulate with reference to chronic pelvic inflammatory disease criterion of therapeutical effect in the practical combination of Chinese and Western medicine department of obstetrics and gynecology of < < > >.Basic healing: transference cure, gynecologial examination sign (comprise uterus, adnexa tenderness, uterine activity degree is limited, and adnexa thickens, inflammatory mass etc.) disappears.Take a turn for the better: symptom partly disappears, and gynecologial examination inflammation enclosed mass dwindles, and adhesion and the tenderness of uterus, adnexa alleviate.Invalid: symptom, sign are without improvement.

2 results

2.1 liang of group curative effect comparison treatment group treatment total effective rates are significantly higher than matched group (P<0.05), in Table 1.

Table 1 liang group curative effect comparison (n, %)

With matched group comparison, χ 2=5.03, P<0.05

The comparison of 2.2 liang of group relapse rates

Two groups of patients follow up a case by regular visits to 1 year (take again lower abdominal pain, lumbago be recurrence), treatment group relapse rate is 6.67% (4/60), matched group relapse rate is 25.46% (14/55), and two groups of comparing differences have highly significant (χ 2=7.67, P<0.01).

2.3 safety evaluatio

Treatment group has the side effect such as feeling sick appears in 5 examples, anorexia, and matched group has 14 examples, all untreated dying away.Two groups of comparing differences have significance (χ ²=5.03, P<0.05).Two groups are showed no obvious adverse reaction and anaphylaxis, and the inspections such as blood, urine, stool routine examination and liver, renal function, electrocardiogram are showed no ANOMALOUS VARIATIONS.

Specific embodiment 1: thank certain, 32 years old, the not fertility always in 3 years of marrying, husband's physical examination is normal.Patient suffered from acute pelvic inflammatory disease and treats 3 weeks at hospital before 2 years, symptom is left hospital after improving.Meet feelings will and do not relax, overwork or eat pungent dry food and feel costa sternales and inferior belly gas pain, belch, constipation, lumbosacral region acid distending pain is uncomfortable before and after passing through and after sexual intercourse, spiritlessness and weakness, leucorrhea with yellow discharge thickness, shows effect repeatedly.Gynecologial examination: yellow secretions is shown in intravaginal; Cervix uteri is smooth has act bitterly; Uterus normal size, mild tenderness; Adnexa left side agglomerate thickens, and has tenderness, and right side thickens, and tenderness is obvious.Lab testing: vaginal secretions is looked into mycete, infusorian (-), numeration of leukocyte (7); Routine blood test is normal.Ultrasound diagnosis prompting: " pelvic hydrops ".Be diagnosed as chronic pelvic inflammatory disease.Control suitable tonifying speen and tonifying kidney, clearing away heat-damp and promoting diuresis, promoting flow of QI and blood, blood stasis-eliminating and stagnation-dissipating.Use following formula: Rhizoma Atractylodis 13g, Fructus Rosae Laevigatae 13g, Caulis Spatholobi 13g, Caulis Akebiae 13g, Herba Plantaginis 12g, Herba Hedyotidis Diffusae 11g, Caulis Sargentodoxae 13g, Radix Rehmanniae 13g, Flos Albiziae 12g, Radix Salviae Miltiorrhizae 13g, Flos Lonicerae 13g, Cortex Phellodendri 12g, Fructus Kochiae 13g, Radix Angelicae Sinensis 13g, Fructus Cnidii 13g, Rhizoma Coptidis 14g, Herba Portulacae 13g, Fructus Rubi 13g, Radix Paeoniae Alba 13g, Radix Curcumae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Radix Sophorae Flavescentis 13g.By the method for the invention, prepare enema or medicine-feeding and add that water is dense to be decocted, extracting juice 80ml, while being cooled to 38～39 ℃, advises the emptying stool of patient, left lateral position, and more than No. 5 hose inserts anus 10～15cm retention enema 1h, every day 1 time.Within 10 days, be 1 course for the treatment of, be used in conjunction 3 all disease disappearances course for the treatment of course for the treatment of, gynecological and ultrasound diagnosis no abnormality seen.Consolidate subsequently 1 month.Second Year is conceived.Follow up a case by regular visits to and have no recurrence.

Specific embodiment 2: the Qin, 26 years old, while carrying out the court's gynaecological examination, symptom has purulent leukorrhea, vaginal mucosa redness, with urgent micturition, frequent micturition, dysurea etc., be diagnosed as gonococcal vaginitis, pelvic inflammatory disease, gonococcal vaginitis are easily invaded even abdominal cavity of cervix uteri, endometrium, fallopian tube, and delay is difficult to radical cure repeatedly.Marry and do not give birth to for 4 years, use enema of the present invention.Side uses: Rhizoma Atractylodis 14g, Fructus Rosae Laevigatae 13g, Caulis Spatholobi 13g, Caulis Akebiae 13g, Herba Plantaginis 12g, Herba Hedyotidis Diffusae 11g, Caulis Sargentodoxae 13g, Radix Rehmanniae 13g, Flos Albiziae 12g, Radix Salviae Miltiorrhizae 13g, Flos Lonicerae 13g, Cortex Phellodendri 12g, Fructus Kochiae 13g, Radix Angelicae Sinensis 13g, Fructus Cnidii 14g, Rhizoma Coptidis 14g, Herba Portulacae 13g, Fructus Rubi 13g, Radix Paeoniae Alba 13g, Radix Curcumae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Radix Sophorae Flavescentis 14g.By the method for the invention, prepare enema or medicine-feeding and add that water is dense to be decocted, extracting juice 80ml, while being cooled to 38～39 ℃, advises the emptying stool of patient, left lateral position, and more than No. 5 hose inserts anus 10～15cm retention enema 1h, every day 1 time.Within 10 days, be 1 course for the treatment of, be used in conjunction 3 courses for the treatment of course for the treatment of all diseases and disappear, after 10 days, pruritus disappears, leucorrhea is normal for gynecological and ultrasound diagnosis no abnormality seen, and after 14 days, vagina is normal without burning sensation, urine, transference cure, and leucorrhea is normal, and abnormal flavour disappears, and pruritus stops.Consolidate 5 courses for the treatment of, now successfully become pregnant.Follow up a case by regular visits to 3 years without recurrence.

Claims

1. a Chinese medicinal enema for the treatment of women's chronic pelvic inflammatory disease, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw materials comprise: 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Caulis Spatholobis, 10～20 parts of Caulis Akebiaes, 10～20 parts of Herba Plantaginiss, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Flos Albiziaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Flos Loniceraes, 10～20 parts of Cortex Phellodendris, 10～20 parts of the Fructus Kochiae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Cnidiis, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Herba Portulacaes, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Curcumaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Sophorae Flavescentiss.

2. treat according to claim 1 the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw materials are: 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Fructus Rosae Laevigatae, 10～15 parts of Caulis Spatholobis, 10～15 parts of Caulis Akebiaes, 10～15 parts of Herba Plantaginiss, 10～15 parts of Herba Hedyotidis Diffusaes, 10～15 parts of Caulis Sargentodoxaes, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Flos Albiziaes, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Flos Loniceraes, 10～20 parts of Cortex Phellodendris, 10～20 parts of the Fructus Kochiae, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Cnidiis, 10～20 parts of Rhizoma Coptidis, 10～20 parts of Herba Portulacaes, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Radix Curcumaes, 10～20 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～20 parts of Radix Sophorae Flavescentiss.

3. treat according to claim 1 the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw materials are: 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Fructus Rosae Laevigatae, 10～20 parts of Caulis Spatholobis, 10～20 parts of Caulis Akebiaes, 10～20 parts of Herba Plantaginiss, 10～20 parts of Herba Hedyotidis Diffusaes, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Flos Albiziaes, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Flos Loniceraes, 10～15 parts of Cortex Phellodendris, 10～15 parts of the Fructus Kochiae, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Cnidiis, 10～15 parts of Rhizoma Coptidis, 10～15 parts of Herba Portulacaes, 10～15 parts of Fructus Rubies, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Radix Curcumaes, 10～15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10～15 parts of Radix Sophorae Flavescentiss.

4. as described in any one in claim 1～3, treat a preparation method for the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, the preparation process of described enema comprises:

C, above-mentioned two kinds of pastes are merged into enema.

5. treat according to claim 4 women's chronic pelvic inflammatory disease the preparation method of Chinese medicinal enema, it is characterized in that, in described step a, get raw material and add in ethanol and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 1.

6. treat according to claim 4 women's chronic pelvic inflammatory disease the preparation method of Chinese medicinal enema, it is characterized in that, in described step b, the medicinal residues that ethanol extraction is crossed are put into water, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams, is the ultrafiltration post ultrafiltration of 5000-10000,1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use, becomes component 2.

7. treat according to claim 4 women's chronic pelvic inflammatory disease the preparation method of Chinese medicinal enema, it is characterized in that, in described step c, above-mentioned two kinds of component paste concentrated solutions are merged, then use ultraviolet ray sterilization bactericidal, become enema.

8. as described in any one in claim 1～3, treat a preparation method for the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, the preparation process of described enema further comprises:

A. described crude drug is put into except Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis to pulverizer grinding and sieving;

9. treat according to claim 8 the preparation method of the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, in described step a, described crude drug is put into except Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis after pulverizer is pulverized and crossed 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves standby; In described step b, particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

10. treat according to claim 8 the preparation method of the Chinese medicinal enema of women's chronic pelvic inflammatory disease, it is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add water heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; In described steps d, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Curcumae and Rhizoma Atractylodis are distilled to the crystallization of vaporizing to obtain, be dried to powder; Above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaims ethanol again, gained filtrate is adjusted to proportion to 1.60, after adding the crystalline powder of the fine powder that sieves and distillation, stir evenly, 100-120 order filters, and after ultraviolet virus killing, uses.