CN103611021B - Be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof - Google Patents

Be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof Download PDF

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CN103611021B
CN103611021B CN201310649088.5A CN201310649088A CN103611021B CN 103611021 B CN103611021 B CN 103611021B CN 201310649088 A CN201310649088 A CN 201310649088A CN 103611021 B CN103611021 B CN 103611021B
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庄志伟
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Shandong New Hope Liuhe Group Co Ltd
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Abstract

The invention discloses a kind of medicine being used for the treatment of Vesica sus domestica inflammation, be made up of following crude drug: Herba Dianthi, the Fructus Kochiae, Caulis Akebiae, Cortex Lycii, pollen, the Rhizoma Anemarrhenae, Radix Gentianae, Pericarpium Citri Reticulatae, Radix Scutellariae, Semen Arecae, Radix Sanguisorbae, Rhizoma Smilacis Scobinicaulis, Radix Rosae Laevigatae, Herba lygodii, Medulla Junci, Herba Lophatheri, Herba Taxilli and Folium Pyrrosiae.The invention has the beneficial effects as follows: the present invention adopts Chinese medicine composition to have evident in efficacy to the treatment of Vesica sus domestica inflammation, and side effect is low, the advantages such as cure rate is high, short treating period, not easily recurrence.

Description

Be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, be particularly a kind ofly used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof.
Background technology
Cystitis refers to the inflammation of bladder mucosa or Submucosa.The scorching cause of disease of Vesica sus domestica mostly is Corynebacterium suis, is invaded caused by bladder infection by blood circulation or urethra.First boar is easily infected, and is transmitted to all sows in pig farm.Symptom: clinically few with frequent micturition, urgent micturition, dysurea, urine volume, urinate red in feature, and depressed with spirit, anorexia.The seasonal disease pig that urinates performance pain is uneasy, and constantly moan, breeding boar penis erects again and again.Muddy and the frowziness of urine, it is blood red for sometimes urinating color.Visible a large amount of leukocyte, pus cell, urothelium, fragment of tissue and pathogen in Urine sediments analyzer.General Symptoms is usually not obvious, and time serious, body temperature raises, and spirit is depressed, loss of appetite.Severe haemorrhage cystitis, also has anemia phenomenon.
Current Therapeutic Method mostly is penicillin 1,000,000 IU streptomycin 1,000,000 IU water for injection 5ml usage: an intramuscular injection, every day 2 times, is used in conjunction 3-5d; 20% hexamethylenamine injection 20-30ml usage a: intravenous injection, every day 1 time, is used in conjunction 3-5d, also can uses Nitrofurantoin.The side effect of Western medicine is larger, and, Western medicine only has obvious curative effect to single disease or a class disease when treating, and for the cystitis that some diseases are more, curative effect is also not obvious, usually need out a lot of Western medicine, and Western medicine is synthesis, and price is high, although there is the Chinese herbal medicine for the treatment of Vesica sus domestica inflammation at present, therapeutic effect is also not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of novel to be used for the treatment of medicine of Vesica sus domestica inflammation and preparation method thereof, and adopt this medicine to have evident in efficacy to the treatment of Vesica sus domestica inflammation, side effect is low, and cure rate is high, not easily the advantage such as recurrence.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of Vesica sus domestica inflammation, it is characterized in that, described medicine is made up of following crude drug: Herba Dianthi, the Fructus Kochiae, Caulis Akebiae, Cortex Lycii, pollen, the Rhizoma Anemarrhenae, Radix Gentianae, Pericarpium Citri Reticulatae, Radix Scutellariae, Semen Arecae, Radix Sanguisorbae, Rhizoma Smilacis Scobinicaulis, Radix Rosae Laevigatae, Herba lygodii, Medulla Junci, Herba Lophatheri, Herba Taxilli and Folium Pyrrosiae.
Described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 10 ~ 20 weight portion, the Fructus Kochiae 10 ~ 25 weight portion, Caulis Akebiae 10 ~ 20 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 20 weight portion, the Rhizoma Anemarrhenae 10 ~ 20 weight portion, Radix Gentianae 16 ~ 26 weight portion, Pericarpium Citri Reticulatae 16 ~ 24 weight portion, Radix Scutellariae 15 ~ 25 weight portion, Semen Arecae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 18 ~ 28 weight portion, Radix Rosae Laevigatae 10 ~ 26 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 10 ~ 24 weight portion, Herba Lophatheri 10 ~ 20 weight portion, Herba Taxilli 10 ~ 15 weight portion and Folium Pyrrosiae 10 ~ 15 weight portion.
Described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 12 ~ 18 weight portion, the Fructus Kochiae 12 ~ 22 weight portion, Caulis Akebiae 10 ~ 17 weight portion, Cortex Lycii 15 ~ 19 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 20 ~ 24 weight portion, Radix Scutellariae 17 ~ 22 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 18 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 17 ~ 20 weight portion, Medulla Junci 15 ~ 22 weight portion, Herba Lophatheri 13 ~ 18 weight portion, Herba Taxilli 12 ~ 15 weight portion and Folium Pyrrosiae 12 ~ 15 weight portion.
Described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 15 weight portion, the Fructus Kochiae 17 weight portion, Caulis Akebiae 16 weight portion, Cortex Lycii 17 weight portion, pollen 13 weight portion, the Rhizoma Anemarrhenae 15 weight portion, Radix Gentianae 24 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Radix Scutellariae 19 weight portion, Semen Arecae 15 weight portion, Radix Sanguisorbae 16 weight portion, Rhizoma Smilacis Scobinicaulis 23 weight portion, Radix Rosae Laevigatae 18 weight portion, Herba lygodii 18 weight portion, Medulla Junci 17 weight portion, Herba Lophatheri 15 weight portion, Herba Taxilli 13 weight portion and Folium Pyrrosiae 13 weight portion.
Described medicine also comprises following crude drug: Exocarpium Benincasae, Rhizoma Kaempferiae, Fructus Jujubae and Rhizoma Curcumae Longae.
Described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 parts, Rhizoma Kaempferiae 12 ~ 17 parts, 10 ~ 20 parts, Fructus Jujubae and 10 ~ 15 parts, Rhizoma Curcumae Longae.
Described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 weight portion, Rhizoma Kaempferiae 12 ~ 17 weight portion, Fructus Jujubae 10 ~ 20 weight portion and Rhizoma Curcumae Longae 10 ~ 15 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method being used for the treatment of the medicine of Vesica sus domestica inflammation, described preparation method comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 2 ~ 3:1;
6th step, at room temperature 12 ~ 24h will be left standstill containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, concentrating under reduced pressure is also dry, obtain and get dry extract, be ground into powder, add the starch relative to this powder quality 1/10, mixing and stirring, obtains powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention adopts Chinese medicine composition to have evident in efficacy to the treatment of Vesica sus domestica inflammation, and side effect is low, the advantages such as cure rate is high, short treating period, not easily recurrence.
Detailed description of the invention
The traditional Chinese medical science thinks damp-heat in the urinary bladder: the product that polyphagia is hot, leads to damp and hot, bet bladder, and damp and hot foul poison is evil invades bladder, and lead to damp and hot, or dampness-heat in the liver and gallbladder bet all can make the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, functioning of bladder is unfavorable, sends out as pyretic stranguria; If the venation of burning, the absurd row of forcing blood, blood with urinating, is then sent out as stranguria with blood; Accumulate for a long time if damp and hot, decoct urine, accumulate over a long period, form sandstone, send out as stranguria caused by urinary stone; If damp-heat accumulation, functioning of bladder is unfavorable, and can not distinguish not turbid, fat liquid goes out with urine, then send out as stranguria marked by chyluria.2. stagnation of QI due to depression of the liver, the liver failing to maintain the normal flow of QI, strongly fragrant in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, cause depression of liver-QI, functioning of bladder is unfavorable, sends out as qi stranguria.3. deficiency of spleen and stomach: pouring is not for a long time healed, and damp and hot consumption hinders healthy energy, and prolonged illness is weak, all can cause deficiency of spleen and stomach.Insufficiency of the spleen and deficiency of QI in middle-JIAO, collapse of QI, then send out as qi stranguria; If suffer from a deficiency of the kidney and instability of kidney-QI, kidney loses astringency inducing, can not restrict fat liquid, and fat liquid is betted, and goes out, then send out as stranguria marked by chyluria with urine; If suffer from a deficiency of the kidney and hyperactivity of fire caused by deficiency of YIN, venation of intimately burning, blood with urinating, is then sent out as stranguria with blood; Just, meet labor and originator, be then stranguria caused by overstrain to sick wound for a long time." Zhu Linzhe, by suffering from a deficiency of the kidney bladder heat thus also." the sick position of stranguria is at kidney and bladder, and relevant with liver spleen.Its pathogenesis is mainly suffered from a deficiency of the kidney, damp-heat in the urinary bladder, disturbance in functioning of QI.Exterior and interior relation between kidney and bladder, the prosperity and decline of kidney qi, directly affects gasification and the folding of bladder.With the passing of time stranguria does not heal, and thermal burn is cloudy, and wet impairment of YANG, easily causes and suffer from a deficiency of the kidney; Suffer from a deficiency of the kidney with the passing of time, damp and hot foul evil poison easily invades bladder, causes the recurrent exerbation of stranguria.Therefore, suffer from a deficiency of the kidney and to have great importance in the generation of stranguria, development and change of pathogenesis with damp-heat in the urinary bladder.Stranguria has void to have reality, and first disease is how real, and how empty prolonged illness is, the weak and prolonged illness patient of first sick body, also can deficiency and excess seeing.Excess syndrome is many at bladder regulating liver-QI, and deficiency syndrome are many at kidney and spleen.Primary disease loses or health element void for causing spleen kidney two by malicious evil invasion and attack for a long time, spleen kidney deficiency.The spleen has the function to transport and transform nutrients, the main gasification of kidney, transporting mistake department, and disturbance in functioning of QI, then retention of water-damp in the body, stop with the passing of time heat-dissipating in damp, damp invasion of lower energizer in bladder, and causes frequent micturition, urgent micturition, dysurea.Heat is burnt channels, the absurd row of forcing blood, or the deficiency of vital energy takes the photograph that blood is unable and hyperamization abnormally rapid or slow pulse is sent out as stranguria with blood, hematuria.Blood stasis does not go, fresh blood not life, and stagnant heat is handed over and fought, and gradually turns to poison, scorchingly hot intertexture, and corrosion muscle, causes the sign of heating, anemia, exhaustion.
The invention provides a kind of medicine being used for the treatment of Vesica sus domestica inflammation, its crude drug comprises: Herba Dianthi, the Fructus Kochiae, Caulis Akebiae, Cortex Lycii, pollen, the Rhizoma Anemarrhenae, Radix Gentianae, Pericarpium Citri Reticulatae, Radix Scutellariae, Semen Arecae, Radix Sanguisorbae, Rhizoma Smilacis Scobinicaulis, Radix Rosae Laevigatae, Herba lygodii, Medulla Junci, Herba Lophatheri, Herba Taxilli and Folium Pyrrosiae.
Fang Zhong, the pharmacology of each crude drug is as follows:
Herba Dianthi: inducing diuresis for treating stranguria syndrome, removing blood stasis stimulates the menstrual flow.Essentials of Matea Medica is said: " fall heart-fire, sharp small intestinal, by bladder pathogenic heat, for controlling pouring key medicine." stranguria.This product purging with bitter and cold drugs, can clear away heart-fire and small intestine fire, heat conduction is descending, has the merit of inducing diuresis for treating stranguria syndrome, for controlling pouring common medicine.Especially the most suitable with pyretic stranguria.Amenorrhea, menoxenia.This product energy removing blood stasis stimulates the menstrual flow.For the amenorrhea of heat in blood stasis blocking or menoxenia especially suitable.
The Fructus Kochiae: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.1. " herbal classic ": " main bladder heat, diuresis.Invigorating middle warmer, beneficial vital essence.Steam in " 2. " not Lu ": " peeling skin, loose malignant boil, hernia abdominal mass, reinforcing YIN-essence, makes people moisten." 3. " property of medicine opinion ": " and Actinolitum are with taking, and main husband's impotence does not rise, QI invigorating benefit power; Control cloudy ovum Huang disease, reduce phlegm and internal heat wind, can make soup and take a shower.It is swollen that " 4. " Japan hanako materia medica ": " controls exopathogenic heat pellet." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sharp bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear sharp fetal heat in pregnancy, damp-heat vaginal discharge.Accumulated heat, apart from skin pruritus due to damp pathogen in " 6. " book on Chinese herbal medicine is original ": " peeling skin." 7. essentials of Matea Medica: " beneficial smart reinforcing YIN-essence, except deficiency-heat, diuresis and treating stranguria." 8. " beautiful Chinese catalpa medicine solution ": " is treated the head and is swollen and ache, and inguinal hernia the moon is ruined, pain in the lumbar region hypochondriac pain, dysentery, malignant boil."
Caulis Akebiae: belong to Lardizabalaceae Akebia.Nature and flavor are bitter, cool.Pathogenic fire purging row water.Promoting blood circulation.Cure mainly hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Interior without damp and hot, body fluid deficiency, gas is weak, and essence is sliding, urinates frequently and is not taken by pregnant women.Clearing away heart-fire, diuresis, stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.Attending effectiveness: clearing away heat and promoting diuresis; Blood circulation and channel invigorating.Main red urine is red; Stranguria with turbid discharge; Edema; Irritable feverish sensation in the chest; Larynx larynx pain; Aphtha of the mouth and tongue; Rheumatic arthralgia; Galactostasis; Amenorrhea; Dysmenorrhea.1. " herbal classic ": main going dislikes worm, and except taste cold and heat, tonneau nine orifices blood vessels joint, makes us not forgetting.2. " WU Pu Bencao ": only spontaneous perspiration.3. " not Lu ": treat spleen subcutaneous ulcer Chang Yumian, the vexed sound of vomiting, goes out speech, treat deaf, the loose all knots of carbuncle disappear, and incised wound, malignant boil, scrofula, Wei folding, nasal polyp, and induced abortion, goes three worms.4. " property of medicine opinion ": cure mainly five types of stranguria, diuresis, switch lattice.Control people to sleep, main edema is floating large, heat clearing away and restlessness relieving more.5. " Treatise on Dietetic Therapy ": boil drink, logical married woman's vim and vigour, again except the gas that cold and heat are obstructed, the scrofula that disappears, incised wound, Wei roll over, and liquor is made wine wonderful.6. supplement to the Herbal: sharp defecation, makes us the therapeutic method to keep the adverse QI flowing downwards not lend oneself to worry and anxiety.7. " Haiyao Bencao, Oversea Materia Medica ": main all fistula skin ulcers; Sore throat and sore throat, and should decoction it, mill is also, anxious namely containing it.
Cortex Lycii: heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.1. " herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." 2. " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat.3. " property of medicine opinion ": " smooth file, face is mixed and well-donely gulped down it, cures mainly kidney family tradition." 4. " Treatise on Dietetic Therapy ": " heat of boning is quenched one's thirst." 5. " book on Chinese herbal medicine is not mentionleted alone ": " controls incised wound." 6. Li Gao: " controls at table without fixed ailment said due to cold or exposure, passes the hectic fever due to YIN-deficiency that corpse has antiperspirant." 7. Wang Haogu: " rushes down kidney fire, falls the lung fire second of the three ten-day periods of the hot season, removes born of the same parents' moderate heat, bring down a fever, correction gas." 8. " daily book on Chinese herbal medicine ": " is controlled postcibal vomiting and is spitted blood; Decoct soup to gargle, only tooth blood, controls the osteomyelitis of the maxillary bone." 9. " detailed outline ": " goes part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney deficiency-heat." 10. " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternate attacks of chills and fever, allly sees blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine."
Pollen: the growth of pollen energy Promote immunity organ; Stop immunosuppressant to the infringement of immune organ; Accelerate the generation of antibody and delay the disappearance of antibody; Promote the increase of T lymphocyte and macrophage, and the phagocytic activity of macrophage can be improved, thus improve the immunologic function of body comprehensively.Two beneficial anemias: pollen has good curative effect to anemia.Charles Robert Richet RChauvin etc. accompany weight and the medical effect of pollen at " clinical physiology and comparative pathology " magazine ran metallographic.They prove to old man as the result of study of food child with two tons of pollen, and pollen is to anemia, and especially the anemia curative effect of child is the most distinguished, and it can make erythrocyte and content of hemoglobin increase fast.
The Rhizoma Anemarrhenae: clearing away heat-fire, promotes the production of body fluid and moisturizes.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.1. for epidemic febrile disease, evil in edema caused by disorder of QI, the edema caused by disorder of QI excess-heat syndrome of high heat, excessive thirst, has the effect of pathogenic fire purging relieving restlessness, has collaborative effect with Gypsum Fibrosum, Folium Bambusae compatibility.2. be used for the treatment of cough due to lung-heat or deficiency of YIN cough caused by dryness, have and let out lung-fire clearly, the effect of nourishing YIN and moistening the lung.Normal and Bulbus Fritillariae Uninbracteatae is same in order to strengthen the merit of clearing away lung-heat and moistening for dryness, as female loose in " collection of prescriptions with notes " two.3., for hyperactivity of fire caused by deficiency of YIN, osteopyrexia and fever, night sweat person, has the effect of nourishing YIN to lower pathogenic fire, and normal and Cortex Phellodendri mutual reinforcement between is for use.4. can let out clearly the fire of lung stomach, again can the moon of nourishing the lung and kidney, therefore the deficiency of YIN should be used for quench one's thirst, disease sees thirsty, drinking water copiously, frequent micturition person, same to Rhizoma Dioscoreae, Fructus Schisandrae Chinensis etc. with the use of heightening the effect of a treatment, as good wine soup.
Radix Sanguisorbae: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore is spitted blood, spitting of blood, epistaxis, and hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting 1. " detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, controls defecation blood disorder.Hemostasis, get and cut off sheet and fry use, its tip then can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.2. " book on Chinese herbal medicine is looked for the truth ": Radix Sanguisorbae, all books are all sayed because of its bitter cold, then can enter part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system heat extraction, know from lower solution in order to do heat.Yan Xingchen and puckery again, ordinary person's disease suffering from, tells the diseases such as nosebleed metrorrhagia hemorrhoidal hamorrhage dysentery, obtains this and then can not understand by puckery blood.By this not without not tally, Ju knows that its heat is not removed, then blood is more than, and its heat is both clear, then blood is from peace, and the main convergence of its property, can fall clearly, again can astringent therapy, then do not consider clearly it and cross and let out, puckery also do not consider itself or stagnant, the antipyretic hemorrhage of strength is also.3. " herbal classic continuous dredge ": Radix Sanguisorbae person does not control not therefore leukorrhagia, do not control the not person bitterly of seven kinds of impairments leukorrheal diseases, only can claim the pain relieving of seven kinds of impairments leukorrheal diseases, visible again.In addition blood degass loose, wind is taken advantage of a weak point in opponent's defence into and is dislike meat, and what wind took advantage of battalion to defend meets with mutually and agitate as antiperspirant, pain can not recover by wind for incised wound, be not all belonging to Radix Sanguisorbae? only pus and blood, all flaccidity, malignant boil, the herpes simplex of " not Lu ", in puerperal, incised wound cream be made by plug, all pushes away class in " herbal classic " and say it.Only disappear wine, except quenching one's thirst, mending exhausted wound.Then its Yi Ruobie has person, so arrogant and air blast enters blood, what different blood deficiency and wind be multiplied by into, wind enters and more consumes its blood, and He Yifeng enters and consumes greatly its body fluid, wind is horizontal to obstruct between QI and blood, not continuing mutually of what unusual pathogen blood, be then still blood deficiency gas and disobey as at all, it is therebetween be disease that pathogenic wind disturbs, and control with wind-transformation gas for anger, cause QI and blood and make to be in harmonious proportion to obtain xun, one of the Eight Diagrams and entering mutually.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, spleen lung can be entered, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the disease such as abundant expectoration cough.Pericarpium Citri tangerinae dispelling the damp pathogen with bitter and warm drugs and can spleen invigorating circulation of qi promoting, therefore be usually used in the diseases such as retention of dampness in middle-JIAO, gastral cavity abdominal distention are vexed, loose stool greasy fur, can compatibility Rhizoma Atractylodis, Cortex Magnoliae Officinalis is with using.Be good at drying dampness to eliminate phlegm again, be control the conventional key medicine that damp-phlegm stops up lung, abundant expectoration cough, reduce for insufficiency of the spleen diet, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and stomach, diet minimizings, dyspepsia, loose stool and diarrhea, often and the fit applications such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Because it can spleen invigorating, can regulate the flow of vital energy again, therefore the assistant being often used as Qi-tonifying drug makes, and can make tonify without causing stagnation, prevent heap soil or fertilizer over and around the roots from holding back and do swollen effect, in addition, Pericarpium Citri tangerinae again can with in, stomach-QI being unable to descend normally, nausea and vomiting can be controlled.
Rhizoma Smilacis Scobinicaulis: the rhizome being liliaceous plant Rhizoma Smilacis Chinensis, bitter in the mouth is pungent, property is flat, can remove rheumatism, invigorates blood circulation, detoxify; Radix Rosae Laevigatae is root or the root bark of rosaceous plant Fructus Rosae Laevigatae, and sour-puckery flavor, property are flat, and function is controlling nocturnal emission with astringent drugs, astringing intestine to stop diarrhea; Herba lygodii, climb up by holding on to pteridophyta for Lygodiaceae is perennial, sweet in the mouth is cold in nature, energy inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, especially arrogates to oneself only urethra pain, has inhibitory action to various bacteria.Effect of Rhizoma Smilacis Scobinicaulis: " Shaanxi Chinese herbal medicine ": except rheumatism, invigorate blood circulation, removing toxic substances, relieving convulsion endogenous wind stopping, anticancer.Dispelling the wind and dampness pathogens lumbago and skelalgia, infantile convulsion, enteritis, furuncle, scrofula, cancerous protuberance.
Radix Rosae Laevigatae: reinforcing the kidney and controlling nocturnal emission.Control spermatorrhea, the enuresis, dysentery is had loose bowels, bleeding not during menses, uterine prolapse, haemorrhoids, scalds.1. " Japan hanako materia medica ": control proglottid of tapeworm, Radix Rosae Laevigatae, file, enters 30, Oryza glutinosa by two liang.Two liters, water, decocts pentahapto, hollow clothes, under the moment rushes down; Again, Fructus Rosae Laevigatae root bark, fries, antidiarrheal blood and metrorrhagia leukorrhagia.2. " detailed outline ": on-slip dysentery, decoct vinegar clothesization bone to choke.3. " the SHENGCAO property of medicine is standby to be wanted ": prosperous blood, reason phlegm-fire, washes infantile malnutrition furuncle, hemorrhoid.4. " classify herbal ": control all and redly collapse leucorrhea, menoxenia, and control seminal emission.5. " south of the Five Ridges gather medicinal herbs record ": hematmesis due to visceral injury, and lean pork decoction.Only toothache can rinsing the mouth a little.6. " Luchuan book on Chinese herbal medicine ": control scald, rheumatic ostalgia, uterine prolapse, apply furuncle.7. " Jiangxi traditional herbal medicine proved recipe ": arresting seminal emission gas, hold back and breath with cough.
Herba lygodii: control urinary tract infection, lithangiuria, nebulousurine leukorrhagia, dysuria, oedema due to nephritis, jaundice due to damp-heat, cold, fever, cough, laryngopharynx swelling and pain, enteritis, dysentery, scald, erysipelas.1. 《 Lv Cliff rock book on Chinese herbal medicine ": " control gonorrhea burning pain person, and dysuria." 2. " the SHENGCAO property of medicine is standby to be wanted ": " specially manages traumatic injury." 3. " classifying herbal ": " anneals.Control stranguria, cough, bones and muscles pain." 4. " Tian Bao book on Chinese herbal medicine ": " suppressing the hyperactive liver Ji fire.Control children's's Scarabaeiform infantile malnutrition, redly collapse pouring drop." 5. " south of the Five Ridges gather medicinal herbs record ": " is treating stranguria, sharp small intestinal, antipyretic poison.Cure the wound cold fanatic, damp and hot generalized edema with distention of the chest and abdomen, pain in the penis, treats variola blackening.6. " Guangzhou flora ": " can the stagnation of the blood be applied, spitting of blood can be gone up again." 7. " Guizhou side's medicine among the people collection ": " controls five types of stranguria nebulousurine, consumer edema." 8. " Traditional Chinese Medicine in Sichuan will ": " is controlled consumptive disease and to be coughed cough caused by pathogenic fire."
Medulla Junci: relieving stranguria by diuresis; Clearing heart fire.Cure mainly: gonorrhea; Edema; Dysuria, the puckery pain of oliguria; Jaundice due to damp-heat; Dysphoria and insomnia; The nocturnal fretfulness in infants; Sore throat; Aphtha of the mouth and tongue; Wound.1. " Kaibao Bencao ": main five types of stranguria.2. " medicine origin ": logical yin orifice is puckery, and Li little Shui, except edema is closed, controls five types of stranguria." curing mainly secret formula " cloud: eliminating the pathogens from the lung.3. " Amplification on Materia Medica addendum ": control acute inflammation of the throat, the nocturnal fretfulness in infants 4. " detailed outline ": fall heart-fire, hemostasis, ventilation, loose swollen, quench the thirst.5. " classify herbal ": be coated with hemorrhoid.6. " the conventional Chinese herbal medicine handbook in the north ": heat clearing and tranquillizing, relieving stranguria by diuresis.7. " Chinese herbal medicine is commonly used in Tibet ": lung heat clearing, pathogenic fire reducing, diuresis.Control dysphoria and insomnia.8. Nanchuan " conventional Chinese herbal medicine handbook ": control laryngitis and cough.9. LongXi, Fujian " practical Chinese herbal medicine ": control children's's fever (of children) accompanied by fear, inflammation of urinary system, skin infection, bulbar conjunctiva polyp.10. " Bencao Jingshu ": Medulla Junci, its light weight leads to, and it is cold in nature, slightly sweet flavor, therefore can tonneau small intestinal steam, descendingly goes out from urine, and small intestinal is the internal organs of the heart, thus also except heart channel heat also.
Herba Lophatheri: sweetly lightly ooze profit, cold in naturely fall clearly, kind fire of leading the heart and small intestinal is descending and inducing diuresis for treating stranguria syndrome cures mainly: in the heart disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, bitterly wind syndrome of head, spasmolytic throb with fear, pestilence be confused vexed, kill small worm, heat extraction delays spleen.1. " detailed outline ": go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, children's's pox poison, outer disease is vicious.2., " the SHENGCAO property of medicine is standby to be wanted ": expectorant is quenched the thirst, except part of the body cavity above the diaphragm housing the heart and lungs fire, bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison.3. " hold spirit book on Chinese herbal medicine ": go gastric heat.4. " book on Chinese herbal medicine is new again ": clearing away heart-fire, diuresis, relieving restlessness is quenched the thirst, and children's's pox poison, outer disease is vicious.5. " vegetation is side just ": expectorant, quench the thirst.Control dysphoria with smothery sensation, cough with asthma, spit blood, the sound of vomiting of vomitting, pediatric epilepsy scared.6. " classify herbal ": control cough and asthma, ophthalmalgia.
Herba Taxilli: invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.[1. " herbal classic ": main lumbago, children's's stiffback, carbuncle, antiabortive, fill skin, hard, tooth, long man.2. " not Lu ": main incised wound, go numbness, woman's metrorrhagia, internal injury is not enough, disease more than puerperal, lower milk.3. " property of medicine opinion ": tire can be made firm, and main bosom pregnant leakage blood is more than.4. " Japan hanako materia medica ": help muscles and bones, beneficial blood vessels.5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": raw Sophora japonica L. person, cures mainly large intestine hematochezia, hemorrhoidal hamorrhage band blood, anal fistula.Raw mulberry person, controls bones and muscles pain, walks grain, anemofrigid-damp arthralgia.Pericarpium Zanthoxyli tree person, controls taste cold, the nauseating regurgitation of food from the stomach of vomiting; Again with controlling syphilitic skin lesions poison, first deficiency and coldness or metrorrhagia under married woman.6. " book on Chinese herbal medicine covers bamboo fish trap ": loose skin infection, chases after rheumatism, but stiffback lumbago.7. " the SHENGCAO property of medicine is standby to be wanted ": disappear heat, and nourishing, chases after wind.To nourish blood heat radiation, make tea-drinking, relaxing muscles and tendons and activating QI and blood in the collateral.8. " beautiful Chinese catalpa medicine solution ": control dysentery.9. " medical center bun is wanted ": hard kidney pathogenic fire purging.10. " book on Chinese herbal medicine is new again ": in fill temperature, control the deficiency of YIN, tonifying YANG road, sharp joint, stimulate the menstrual flow water, benefiting blood and regulating blood circulation, antiabortive analgesic therapy.(11) " pharmacognosy ": control arteriosclerotic hypertension.
Folium Pyrrosiae: relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.1. " herbal classic ": " main consumptive fever pathogen, five difficulty in urinations are obstructed, diuresis water channel." 2. " not Lu ": " be the tired therapeutic method to keep the adverse QI flowing downwards only, and logical bladder is full, and mend five kinds of over strain, An Wuzang, removes aversion to wind, beneficial vital essence." 3. " Japan hanako materia medica ": " is controlled and is drenched drop incontinence of urine." 4. " Bencao Tujing ": " fries end, and cold wine is taken after mixing with liquid, and treats carbuncle on the back." 5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " only beautiful pain in the penis." 6. " detailed outline ": " main metrorrhagia, incised wound, lung heat clearing gas." 7. " Zhiwu Mingshi Tukao ": " controls phlegm-fire, steams clothes with lean meat." 8. " east, Fujian book on Chinese herbal medicine ": " controls dysentery." 9. " book on Chinese herbal medicine is high former ": Folium Pyrrosiae, cures mainly consumptive fever pathogen person, consumptive fever is at bone, and pathogen is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid difficulty in urinations, dysuria also.Folium Pyrrosiae helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes under lung qi, then capable the and normal urination of water channel.
Radix Gentianae: bitter in the mouth, cold in nature, enters liver, gallbladder meridian, has heat clearing and damp drying, falls the effect of letting out liver-fire and function of gallbladder promoting, and the breast side of body being mainly used in dampness-heat of the liver caused is had a pain, and bitter taste is deaf, conjunctival congestion and swelling pain; Jaundice due to damp-heat; The dizzy order of flaming up of liver-fire swells; The high heat of liver-fire wind-transformation is through taking out; The card such as leucorrhea, dysuria of damp invasion of lower energizer.
Radix Scutellariae: bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire invades the swollen card of carbuncle sore poison of excessive skin.Radix Scutellariae has antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, there is certain inhibitory action, to upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus.
Semen Arecae: bitter in the mouth, pungent, puckery, property wets, nontoxic, cures mainly rapid digestion of food and relieves oedema or abdominal distension through diuresis or purgation, and kills Enterozoa, volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp ball key, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention stomachache, defecation can not, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases.
Medicine of the present invention is preferably made up of the crude drug of following parts by weight: Herba Dianthi 10 ~ 20 weight portion, the Fructus Kochiae 10 ~ 25 weight portion, Caulis Akebiae 10 ~ 20 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 20 weight portion, the Rhizoma Anemarrhenae 10 ~ 20 weight portion, Radix Gentianae 16 ~ 26 weight portion, Pericarpium Citri Reticulatae 16 ~ 24 weight portion, Radix Scutellariae 15 ~ 25 weight portion, Semen Arecae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 18 ~ 28 weight portion, Radix Rosae Laevigatae 10 ~ 26 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 10 ~ 24 weight portion, Herba Lophatheri 10 ~ 20 weight portion, Herba Taxilli 10 ~ 15 weight portion and Folium Pyrrosiae 10 ~ 15 weight portion.
Medicine of the present invention is preferably made up of the crude drug of following parts by weight: Herba Dianthi 12 ~ 18 weight portion, the Fructus Kochiae 12 ~ 22 weight portion, Caulis Akebiae 10 ~ 17 weight portion, Cortex Lycii 15 ~ 19 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 20 ~ 24 weight portion, Radix Scutellariae 17 ~ 22 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 18 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 17 ~ 20 weight portion, Medulla Junci 15 ~ 22 weight portion, Herba Lophatheri 13 ~ 18 weight portion, Herba Taxilli 12 ~ 15 weight portion and Folium Pyrrosiae 12 ~ 15 weight portion.
Medicine of the present invention is preferably made up of the crude drug of following parts by weight: Herba Dianthi 15 weight portion, the Fructus Kochiae 17 weight portion, Caulis Akebiae 16 weight portion, Cortex Lycii 17 weight portion, pollen 13 weight portion, the Rhizoma Anemarrhenae 15 weight portion, Radix Gentianae 24 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Radix Scutellariae 19 weight portion, Semen Arecae 15 weight portion, Radix Sanguisorbae 16 weight portion, Rhizoma Smilacis Scobinicaulis 23 weight portion, Radix Rosae Laevigatae 18 weight portion, Herba lygodii 18 weight portion, Medulla Junci 17 weight portion, Herba Lophatheri 15 weight portion, Herba Taxilli 13 weight portion and Folium Pyrrosiae 13 weight portion.
Medicine of the present invention also comprises following crude drug: Fructus Schisandrae Chinensis, Rhizoma Kaempferiae, Fructus Jujubae and Rhizoma Curcumae Longae; Wherein,
Fructus Schisandrae Chinensis: temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, disease such as seminal emission chronic diarrhea, forgetful insomnia etc.Schisandra fruit implementation Chinese medicine function supplementing QI for promoting the production of body fluid, nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, to calm the nerves, chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, disease such as seminal emission chronic diarrhea, forgetful insomnia etc. can be controlled.Pharmacological testing proves excitement and the process of inhibition that can regulate central nervous system, promotes body metabolism, regulates gastric juice and bile secretion, has reducing effect to hepatitis convalescent period transaminase rising person." book on Chinese herbal medicine converges and says ": Fructus Schisandrae Chinensis, the medicine that astringing QI promotes the production of body fluid also.Therefore the gas of Tang Materia Medica main convergence deficiency of the lung chronic cough dissipation.All deficiency of vital energy dyspnea with rapid respiration, cough with dyspnea strains, and spirit is not enough, and arteries and veins gesture is hollow, or impairment caused by overstrain yang-energy, limbs are won thin, or empty gas is superior, and spontaneous perspiration comes frequently, or essence unit exhausts, deficiency of YIN fire is scorching, or exhaustion of YIN YANG-depletion, refreshing scattered pulse takes off, and control it with Fructus Schisandrae Chinensis, salty holding back with its acid is promoted the production of body fluid, and protects reinforcing premodial qi and without spermatorrhea also.So upper enter lung, under enter kidney, enter the benefit that lung has Jiyuan of promoting the production of body fluid, entering kidney has controlling nocturnal emission with astringent drugs to support the merit of marrow.Cruel and the alcohol of Fructus Schisandrae Chinensis main component schizandrin, Fructus Schisandrae Chinensis, its mechanism of action suppresses the vigor of transaminase in Hepatocyte, and induced microparticle body produces cytochrome P-450, the detoxification ability of enhance hepatocyte, and can promote hepatocellular reparation.
Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp, there is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, the cards such as insufficiency of vital energy and blood, has a headache and fever, sweating hot blast.
Rhizoma Curcumae Longae: bitter in the mouth, pungent, warm in nature, enters Liver Channel, has removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia, twinges, amenorrhea, lump in the abdomen for the breast side of body, rheumatism shoulder arm pain, the cards such as tumbling and swelling.
Rhizoma Kaempferiae: warm in nature, acrid in the mouth, returns stomach warp, has warming middle-JIAO, help digestion, and effect of pain relieving cures mainly trusted subordinate's cold type of pain, stops dyspepsia, traumatic injury, toothache, and diet such as not to disappear at the card.
Medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 weight portion, Rhizoma Kaempferiae 12 ~ 17 weight portion, Fructus Jujubae 10 ~ 20 weight portion and Rhizoma Curcumae Longae 10 ~ 15 weight portion.
Medicine of the present invention is preferably made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 weight portion, Rhizoma Kaempferiae 12 ~ 17 weight portion, Fructus Jujubae 10 ~ 20 weight portion and Rhizoma Curcumae Longae 10 ~ 15 weight portion.
Present invention also offers a kind of feedstuff being used for the treatment of Vesica sus domestica inflammation, its raw material is made up of the raw material of following parts by weight: Semen Maydis powder 50-70 weight portion, Oryza glutinosa 50-70 weight portion, rice 50-70 weight portion, potato class 50-70 weight portion, Fructus Hordei Vulgaris 50-70 weight portion, Sorghum vulgare Pers. 50-70 weight portion, Semen avenae nudae 50-70 weight portion, Fructus Cucurbitae moschatae powder 50-70 weight portion, bean cake 50-70 weight portion and be used for the treatment of the medicine 5-10 weight portion of Vesica sus domestica inflammation.
The preparation method of feedstuff comprises the following steps:
The first step, prepares drug powder;
Second step, by each raw material pulverizing in feedstuff, mixing and stirring, obtains mixture;
3rd step, adds granulator and to granulate to obtain pellet after mixture being dropped in blender mixing.
Embodiment 1 medicine 1
By Herba Dianthi 15g, Fructus Kochiae 17g, Caulis Akebiae 16 g, Cortex Lycii 17 g, pollen 13g, Rhizoma Anemarrhenae 15g, Radix Gentianae 24g, Pericarpium Citri Reticulatae 23g, Radix Scutellariae 19g, Semen Arecae 15g, Radix Sanguisorbae 16g, Rhizoma Smilacis Scobinicaulis 23g, Radix Rosae Laevigatae 18g, Herba lygodii 18g, Medulla Junci 17g, Herba Lophatheri 15g, Herba Taxilli 13g and Folium Pyrrosiae 13g, drop into pulverizer and carry out pulverization process, obtain corase meal, obtain mixture; The mixture of acquisition is carried out first time soak by water process, decocting time is 4 hours, and the amount of the water added and the mass ratio of mixture are 8:1, and decoction liquor is filtered, and obtains first time decoction liquor; Medicinal residues after the first time decoction liquor obtained being filtered carry out second time and decoct process, and decocting time is 3 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 7:1, and decoction liquor is filtered, and obtains second time decoction liquor; Merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10; In mixture clear paste, add the ethanol that determining alcohol is 95%, obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 3:1; At room temperature will leave standstill 19h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, add the starch relative to this powder quality 1/10, mixing and stirring, obtain powder.
Embodiment 2 medicine 2
Herba Dianthi 13g, Fructus Kochiae 17g, Caulis Akebiae 15g, Cortex Lycii 16g, pollen 13g, Rhizoma Anemarrhenae 14g, Radix Gentianae 25g, Pericarpium Citri Reticulatae 21g, Radix Scutellariae 19g, Semen Arecae 15g, Radix Sanguisorbae 17g, Rhizoma Smilacis Scobinicaulis 22g, Radix Rosae Laevigatae 17g, Herba lygodii 16g, Medulla Junci 15g, Herba Lophatheri 16g, Herba Taxilli 13g, Folium Pyrrosiae 13g, Exocarpium Benincasae 14g, Rhizoma Kaempferiae 15g, Fructus Jujubae 15g and Rhizoma Curcumae Longae 12g are dropped into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture; The mixture of acquisition is carried out first time soak by water process, decocting time is 3 hours, and the amount of the water added and the mass ratio of mixture are 7:1, and decoction liquor is filtered, and obtains first time decoction liquor; Medicinal residues after first time decoction liquor being filtered carry out second time and decoct process, and decocting time is 3 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 8:1, and decoction liquor is filtered, and obtain second time decoction liquor; Merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.20; In mixture clear paste, add the ethanol that determining alcohol is 95%, obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 3:1; At room temperature will leave standstill 20h containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, add the starch relative to this powder quality 1/10, mixing and stirring, obtain powder.
Embodiment 3 feedstuff
Present invention also offers a kind of feedstuff being used for the treatment of Vesica sus domestica inflammation, its raw material is made up of the raw material of following kg number: Semen Maydis powder 62kg, Oryza glutinosa 57kg, rice 58kg, potato class 63kg, Fructus Hordei Vulgaris 57kg, Sorghum vulgare Pers. 63kg, Semen avenae nudae 51kg, Fructus Cucurbitae moschatae powder 55kg, bean cake 53kg and be used for the treatment of the medicine 7kg of Vesica sus domestica inflammation.
Wherein, the medicine being used for the treatment of Vesica sus domestica inflammation is the medicine in embodiment 2.
The preparation method of feedstuff comprises the following steps:
The first step, prepares drug powder;
Second step, by each raw material pulverizing in feedstuff, mixing and stirring, obtains mixture;
3rd step, adds granulator and to granulate to obtain pellet after mixture being dropped in blender mixing.
Acute toxicity test
Require to carry out prerun according to acute toxicity test, find that test medicine cannot measure LD50.Therefore carry out maximum dosage-feeding test in a day.Get above-mentioned mice 40, fasting can't help water after 12 hours, administration group and water matched group is divided at random by body weight, often organize 20, administration group gives the medicinal liquid 0.4ml/10g of the crude drug amount 2.4g/ml concentration of the medicine prepared containing embodiment 1, gavage one day 2 times, make dosage in a day reach symphysis dose 192.0g/kg, water matched group is to the water of equal volume.After each treated animal administration, 5, every box, normal raising, close observation, equal Continuous Observation seven days, the toxic reaction that record may occur and death condition, after administration, mice outward appearance hair color light, behavioral activity is normal, pathologic neural reflex without exception occurs, in seven days, feed is good, and other Novel presentation is seen at end, body weight change no significant difference and none animal dead compared with water matched group, the main organs such as the perusal heart, liver, spleen, lung, kidney, without general pathology changes such as significantly hemorrhage, tissue degeneratiaon, necrosis.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, the test result of result as embodiment 1 medicine is identical.
Long term toxicity test
The medicine of the embodiment of the present invention 1 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.Use the medicine of the embodiment of the present invention 2 to carry out above-mentioned test to mice, the test result of result as embodiment 1 medicine is identical.
Clinical trial
(1) laboratory animal
Pig farm, Shandong about 75kg, kind is that ternary is mixed white pig, ill pig shows as: listless, loss of appetite, amount of drinking water increases, and body temperature is slightly high, moist, dirty around sow external genital mild swelling, vaginal orifice, cloudy urine, state of an illness severe one is urinated again and again, the few and turbidity zone color of urine volume, or dysuria, there is pain reaction when urinating, find through urine examination, containing corynebacterium in urine, check occurring that the sick pig of hematuria is dissected, discovery wall of urinary bladder thickens, interior foul smelling taste urine, slough and extract, and surface is covered with canescence purulence pseudomembrane; Make a definite diagnosis the natural cases 157 of cystitis.
(2) test method
Select 150 as supplying examination animal, the method of completely random is adopted to be divided into three groups, often organize 50 ill pigs, adopt the medicine (embodiment group 1) of the embodiment of the present invention 1, the medicine (embodiment group 2) of embodiment 2 and hexamethylenamine injection (matched group) to treat respectively.Wherein, 20% hexamethylenamine injection is that Shanxi constant force animal pharmaceutical estate company limited produces, and lot number 20120613, usage: an intravenous injection 20-30m, every day 1 time, is used in conjunction 5-7d.Embodiment group 1 and embodiment group 2 add the embodiment 1 of 3%-10% and the medicine of embodiment 2 respectively in the daily ration of pig, twice daily, use 3 days continuously.
(3) Outcome measure
Ill pig spirit, body temperature and appetite all recover normal, and genitals is without the red and swollen phenomenon of swelling, and urine recovers normal, for effective; Ill pig spirit and appetite are recovered normally, and genitals is slightly red and swollen, but not obvious, and urine is normal, for effectively; Ill pig spirit, body temperature and appetite are without significant change, and genitals is red and swollen, for invalid.
(4) result
Average 3 days of 100 the ill pigs treated with the medicine 1 of the embodiment of the present invention 1 and 2 and medicine 2 can rehabilitation, and total effective rate 92% and 94%, and 50 for the treatment of of control group pigs, the course for the treatment of is longer, rehabilitation in average 6 days, total effective rate 80%, and result is as shown in table 1.
Table 1 therapeutic effect synopsis
Data as can be seen from table 1: compared with matched group, use the Drug therapy Vesica sus domestica of the embodiment of the present invention 1 and 2 scorching, have therapeutic effect short, the advantage that cure rate is high; After experiment terminates, continue to observe half a year to experiment pig, statistics finds that the relapse rate of embodiment group 1 is 16%, and the relapse rate of embodiment group 2 is 10%, and the relapse rate of matched group is 46%.
Concrete case
Case 1
On July 13rd, 2012, the sow that Zhang family raises, spirit is overcast, and inappetence is moist around external genital mild swelling, vaginal orifice, dirty, cloudy urine, and state of an illness severe one is urinated again and again, the few and turbidity zone color of urine volume.Be diagnosed as Vesica sus domestica inflammation, Therapeutic Method: the medicine adding the embodiment of the present invention 1 of feedstuff gross mass 5%, twice daily, use recovery from illness in three days continuously.
Case 2
On April 26th, 2013, three boars of Wang family and a sow, spirit is overcast, and appetite declines, the seasonal disease pig that urinates performance pain is uneasy, and constantly moan, breeding boar penis erects again and again, muddy and the frowziness of urine, it is blood red for sometimes urinating color, sow external genital mild redness.All be diagnosed as Vesica sus domestica inflammation, Therapeutic Method: the medicine adding the embodiment of the present invention 2 of feedstuff gross mass 5%, twice daily, use recovery from illness in three days continuously.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. be used for the treatment of the medicine of Vesica sus domestica inflammation, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 10 ~ 20 weight portion, the Fructus Kochiae 10 ~ 25 weight portion, Caulis Akebiae 10 ~ 20 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 20 weight portion, the Rhizoma Anemarrhenae 10 ~ 20 weight portion, Radix Gentianae 16 ~ 26 weight portion, Pericarpium Citri Reticulatae 16 ~ 24 weight portion, Radix Scutellariae 15 ~ 25 weight portion, Semen Arecae 10 ~ 20 weight portion, Radix Sanguisorbae 10 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 18 ~ 28 weight portion, Radix Rosae Laevigatae 10 ~ 26 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 10 ~ 24 weight portion, Herba Lophatheri 10 ~ 20 weight portion, Herba Taxilli 10 ~ 15 weight portion and Folium Pyrrosiae 10 ~ 15 weight portion.
2. the medicine being used for the treatment of Vesica sus domestica inflammation according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 12 ~ 18 weight portion, the Fructus Kochiae 12 ~ 22 weight portion, Caulis Akebiae 10 ~ 17 weight portion, Cortex Lycii 15 ~ 19 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 20 ~ 24 weight portion, Radix Scutellariae 17 ~ 22 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 18 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 17 ~ 20 weight portion, Medulla Junci 15 ~ 22 weight portion, Herba Lophatheri 13 ~ 18 weight portion, Herba Taxilli 12 ~ 15 weight portion and Folium Pyrrosiae 12 ~ 15 weight portion.
3. the medicine being used for the treatment of Vesica sus domestica inflammation according to claim 1, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 15 weight portion, the Fructus Kochiae 17 weight portion, Caulis Akebiae 16 weight portion, Cortex Lycii 17 weight portion, pollen 13 weight portion, the Rhizoma Anemarrhenae 15 weight portion, Radix Gentianae 24 weight portion, Pericarpium Citri Reticulatae 23 weight portion, Radix Scutellariae 19 weight portion, Semen Arecae 15 weight portion, Radix Sanguisorbae 16 weight portion, Rhizoma Smilacis Scobinicaulis 23 weight portion, Radix Rosae Laevigatae 18 weight portion, Herba lygodii 18 weight portion, Medulla Junci 17 weight portion, Herba Lophatheri 15 weight portion, Herba Taxilli 13 weight portion and Folium Pyrrosiae 13 weight portion.
4. be used for the treatment of the medicine of Vesica sus domestica inflammation, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 weight portion, Rhizoma Kaempferiae 12 ~ 17 weight portion, Fructus Jujubae 10 ~ 20 weight portion and Rhizoma Curcumae Longae 10 ~ 15 weight portion.
5. the medicine being used for the treatment of Vesica sus domestica inflammation according to claim 4, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 ~ 17 weight portion, the Fructus Kochiae 13 ~ 20 weight portion, Caulis Akebiae 13 ~ 18 weight portion, Cortex Lycii 15 ~ 20 weight portion, pollen 10 ~ 15 weight portion, the Rhizoma Anemarrhenae 10 ~ 18 weight portion, Radix Gentianae 21 ~ 26 weight portion, Pericarpium Citri Reticulatae 18 ~ 22 weight portion, Radix Scutellariae 17 ~ 21 weight portion, Semen Arecae 12 ~ 18 weight portion, Radix Sanguisorbae 12 ~ 20 weight portion, Rhizoma Smilacis Scobinicaulis 20 ~ 25 weight portion, Radix Rosae Laevigatae 13 ~ 23 weight portion, Herba lygodii 15 ~ 20 weight portion, Medulla Junci 15 ~ 20 weight portion, Herba Lophatheri 16 ~ 18 weight portion, Herba Taxilli 10 ~ 15 weight portion, Folium Pyrrosiae 10 ~ 15 weight portion, Exocarpium Benincasae 10 ~ 18 weight portion, Rhizoma Kaempferiae 12 ~ 17 weight portion, Fructus Jujubae 10 ~ 20 weight portion and Rhizoma Curcumae Longae 10 ~ 15 weight portion.
6. the medicine being used for the treatment of Vesica sus domestica inflammation according to claim 4, it is characterized in that, described medicine is made up of the crude drug of following parts by weight: Herba Dianthi 13 weight portion, the Fructus Kochiae 17 weight portion, Caulis Akebiae 15 weight portion, Cortex Lycii 16 weight portion, pollen 13 weight portion, the Rhizoma Anemarrhenae 14 weight portion, Radix Gentianae 25 weight portion, Pericarpium Citri Reticulatae 21 weight portion, Radix Scutellariae 19 weight portion, Semen Arecae 15 weight portion, Radix Sanguisorbae 17 weight portion, Rhizoma Smilacis Scobinicaulis 22 weight portion, Radix Rosae Laevigatae 17 weight portion, Herba lygodii 16 weight portion, Medulla Junci 15 weight portion, Herba Lophatheri 16 weight portion, Herba Taxilli 13 weight portion, Folium Pyrrosiae 13 weight portion, Exocarpium Benincasae 14 weight portion, Rhizoma Kaempferiae 15 weight portion, Fructus Jujubae 15 weight portion and Rhizoma Curcumae Longae 12 weight portion.
7. the preparation method being used for the treatment of the medicine of Vesica sus domestica inflammation as described in any one of claim 1-6, is characterized in that, described preparation method comprises the following steps:
The first step, takes all crude drug according to parts by weight, drops into pulverizer and carries out pulverization process, obtain corase meal, obtain mixture;
Second step, the mixture that the first step obtains is carried out first time soak by water process, and decocting time is 2 ~ 4 hours, and the amount of the water added and the mass ratio of mixture are 6 ~ 9:1, and decoction liquor is filtered, and obtains first time decoction liquor;
3rd step, medicinal residues after the first time decoction liquor filtration obtained by second step carry out second time and decoct process, and decocting time is 2 ~ 4 hours, and the mass ratio of the mixture that the amount of the water added and the first step obtain is 6 ~ 10:1, decoction liquor is filtered, and obtains second time decoction liquor;
4th step, merge decoction liquor and second time decoction liquor for the first time, concentrated, obtain mixture clear paste, under 60 DEG C of conditions, the relative density of clear paste is 1.10 ~ 1.20;
5th step, adds the ethanol that determining alcohol is 95% in mixture clear paste, and obtain containing alcohol clear paste, the ethanol added and the mass ratio of clear paste are 2 ~ 3:1;
6th step, at room temperature 12 ~ 24h will be left standstill containing alcohol clear paste, get supernatant, clear paste residue is carried out filtration treatment, the liquid of filtration and supernatant merge, concentrating under reduced pressure is also dry, obtain and get dry extract, be ground into powder, add the starch relative to this powder quality 1/10, mixing and stirring, obtains powder.
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CN104027683B (en) * 2014-06-20 2017-01-11 湖州天健兽药有限公司 Traditional Chinese medicine for treating pig cystitis
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