CN104398934A

CN104398934A - Traditional Chinese medicine combination for treating cutaneous pruritus and preparation method thereof

Info

Publication number: CN104398934A
Application number: CN201410753490.2A
Authority: CN
Inventors: 孔红梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-12-11
Filing date: 2014-12-11
Publication date: 2015-03-11

Abstract

The invention discloses a traditional Chinese medicine combination for treating cutaneous pruritus. The traditional Chinese medicine combination is composed of the following ingredients in parts by weight: radix sophorae flavescentis, fructus cnidii, hydnocarpus sp, caltrop, dried rehamnnia root, Angelica sinensis, safflower carthamus, fructus kochiae, rhizoma smilacis glabrae, bombyx batryticatus, cortex moutan, cortex phellodendri, oriental arborvitae, glabrous greenbrier rhizome, raw fossil fragments, raw oysters, chrysanthemum, cortex dictamni, tenuifolia, divaricate saposhnikovia root, fructus gardeniae, rhizoma alismatis and gentiana scabra bge. The traditional Chinese medicine combination has the functions of clearing heat, expelling dampness, dispelling wind, arresting itching, clearing heat and cooling blood, and can effectively treat cutaneous pruritus.

Description

A kind of Chinese medicine composition for skin pruritus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for skin pruritus.The invention still further relates to the preparation method of this Chinese medicine composition.

Background technology

Skin pruritus is one of common clinically dermatosis, is especially more common in old people.It is characterized by based on pruritus, and without primary lesion.Be limited innings property and general two kinds can be divided clinically.Pruritus is a kind of conscious pruritus and clinically without the dermatosis of primary lesion.The cause of disease of pruritus does not still understand, thinks relevant with some disease, as diabetes, hepatopathy, nephropathy etc. more; Also stimulate with some extraneous factors has, closes simultaneously, as cold, warm, chemical & blended fabric etc.Skin pruritus also may be a kind of skin neurosis illness.To skin pruritus be only had and be referred to as pruritus without primary cutaneous impairer clinically, belong to the category of the traditional Chinese medical science " pruritus ".Skin pruritus divides plain edition and anaphylactic type.Can occur by whole body, be many with face, the back of the body and extremity especially.Plain edition skin pruritus is generally that skin too dry causes, or has bacterial fungus to cause.

At present, the external used medicine being used for the treatment of skin pruritus is main mainly with hormone medicine greatly, such as: PIYANPING, WUJI GAO, Pevisone, dexamethasone class etc., this hormone medicine possibility effect when bringing into use is fine, some skin symptom can be made to disappear very soon after one painting, probably can there is coating area skin extremely in this medicine after life-time service a period of time, as secondary infection, folliculitis, telangiectasis, corticosteroid dermatitis, atrophoderma, the side effect such as pigmentation, women also may occur that hair such as to increase at the severe reaction, and easily recur after drug withdrawal, effect is not ideal enough, a lot of inconvenience is brought to the life of patient, patient mental aspect also subjects huge pressure.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has antipruritic fast, good effect for treatment skin pruritus, not easily recurs, cheap, the feature that healing time is short.

Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of this treatment skin pruritus.

Inventor is in clinical treatment practice for many years, observe the misery that skin pruritus is brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula of the Chinese medicine preparation for skin pruritus repeatedly, the present invention selects Radix Sophorae Flavescentis, Fructus Cnidii, Semen Hydnocarpi, Fructus Tribuli, Radix Rehmanniae, Radix Angelicae Sinensis, Flos Carthami, the Fructus Kochiae, Rhizoma Smilacis Glabrae, Bombyx Batryticatus, Cortex Moutan, Cortex Phellodendri, Cacumen Platycladi, Fructus Schisandrae Chinensis, Os Draconis, Concha Ostreae, Flos Chrysanthemi, Cortex Dictamni, Herba Schizonepetae, Radix Saposhnikoviae, Fructus Gardeniae, Rhizoma Alismatis, Radix Gentianae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is heat clearing and damp drying, dispelling wind for relieving itching, effect of clearing away heat and cooling blood, thus effectively can treat skin pruritus.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Sophorae Flavescentis: be the root of pulse family perennial fallen leaves semishrub plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor: bitter, cold in nature.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Effect: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.Treatment eczema scabies.Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to the skin pruritus that eczema scabies causes.Compendium of Material Medica is recorded: the bitter cold of Radix Sophorae Flavescentis, Cortex Phellodendri, all can the kidney invigorating, and lid gets its bitter dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again.

Fructus Cnidii: be the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..Nature and flavor: acrid, bitter, warm.Return kidney channel.Effect: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing." book on Chinese herbal medicine newly organized " is recorded: Fructus Cnidii, and function is quite strange, inside and outsidely all can treat, and external treatment is especially good.Clinical practice: be used for the treatment of skin eczema and pruritus, as chronic eczema acute attack, pompholyx rotten to the corn phase, eczema scrotum, pruritus vulvae, scabies, tinea etc.

Semen Hydnocarpi: Flacourtiaceae Hydnocarpus plant Semen Hydnocarpi Hydnocarpus anthe lmint icus Pierre ex Laness. and Hydnocarpus hainanensis (Merr.) Sleum. H. hainanensis (Merr.) Sleum., is used as medicine with seed.Nature and flavor: pungent, heat, poisonous.Return liver,spleen,kidney warp.Effect: dispel the wind, merit poison, parasite killing.For leprosy; Scabies, tinea are controlled in external.Be usually used in disease such as treatment leprosy, urticaria etc. clinically." Bencao Jingshu ": Semen Hydnocarpi, the pungent wind that can fall apart, bitter energy parasite killing dampness, the warm meridians that can pass through, common people are in order to control large scrofula caused by pathogenic wind disease, and all skin ulcers of tinea corporis mange, know this meaning ear.

Fructus Tribuli: for zygophyllaceae is annual or the mature fruit of herbaceos perennial Fructus Tribuli Tribulus ter-restris L..Nature and flavor: pungent, bitter, tepor; Slightly poisonous.Return Liver Channel.Effect: suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.Record in " book on Chinese herbal medicine just ": Fructus Tribuli, removing heat from blood nourishes blood, also kind nourishing YIN.Should deburring be fried by benefit, should smash by Lian Cisheng with cool.Wind is gone to detoxify, Bai Zheliang.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the effect of nourishing YIN and clearing away heat.

Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.Modern medicine study confirms, Radix Angelicae Sinensis has antibacterial, antiinflammation, the pain relieving of Radix Angelicae Sinensis energy promoting blood circulation and detumescence, again can tonic blood and growing muscle, therefore commonly uses for surgery more, is often equal to Flos Carthami and uses.

Flos Carthami: be the tubular corolla of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, and energy blood circulation promoting and blood stasis dispelling, stimulate the menstrual flow pulse-taking.

The Fructus Kochiae: be the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor: pungent, bitter, cold.Return kidney, urinary bladder channel.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Rhizoma Smilacis Glabrae: be the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Nature and flavor: sweet, light are flat.Return liver, stomach warp.Effect: removing damp-heat; Let out turbid removing toxic substances; Easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain." book on Chinese herbal medicine justice ": Rhizoma Smilacis Glabrae, dampness removing reduces phlegm and internal heat, and can enter network, searches to pick and damp and hot accumulates poison.It separates hydrargyrum, Calomelas poison person, and it is up that receive poison with ascending, and this leads as business under oozing profit, therefore specially control Fructus Myricae rubrae skin infection, gos deep into hundred networks, arthralgia, even rotten, and poison fire is up again, and throat pain is burst, and all dislike disease.

Bombyx Batryticatus: the larva for Bombycidae insecticide silkworm Bombyx mori Linnaeus. 4 ~ 5 age infects (or artificial vaccination) muscardine Beauveria bassiana(Bals.) Vuillant and lethal larva dry body.Nature and flavor: salty, pungent are flat.Return liver, lung, stomach warp.Effect: expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Cure mainly: apoplectic aphasia, middle tuyere nose eye are oblique.Clinical practice, Bombyx Batryticatus can treat headache due to pathogenic wind-heat, conjunctival congestion, pharyngalgia, rubella pruritus.Bombyx Batryticatus is pungent loose, enters liver, lung two warp, has exogenous wind of dispelling, loose wind heat, pain relieving, antipruritic merit.

Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are bitter, cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.This product cold nature, can clearing heat in YING system divide, blood system excess-heat, have the merit of cooling blood for hemostasis, and Cortex Moutan is pungent cold, is apt to into blood system, can removing heat from blood with hemostasis, can invigorate blood circulation with dissipating blood stasis again, the kind logical heat in blood stasis of blood is stagnant.

Cortex Phellodendri: be the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phellodendron amurense Rupr..Nature and flavor: bitter, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Cortex Phellodendri decoct, water logging agent all have inhibitory action in various degree in external to multiple pathogenic dermatophytes, trichomonas vaginitis etc.

Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor: bitter, puckery, cold.Return lung, liver, spleen channel.Effect: cooling blood for hemostasis, growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.Cacumen Platycladi bitter in the mouth cold in nature, energy cooling blood for hemostasis, experimental study has the effect of certain anti-inflammation.

Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Os Draconis: Os Draconis be ancient times mammal as if the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor: sweet, puckery are flat.Enter the heart, liver, kidney, large intestine channel.Effect: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.

Concha Ostreae: be the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Grosse or Crassostrea rivularis Ostrea rivularis Gould etc.Nature and flavor: salty, be slightly cold.Return liver, gallbladder, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating.

Flos Chrysanthemi: be the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Nature and flavor: sweet, bitter, are slightly cold.Return lung, Liver Channel.Effect: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.The merit of Flos Chrysanthemi heat-clearing and toxic substances removing is excellent, is surgery key medicine, is mainly used in the disease of pathopyretic ulcer, red and swollen heat pain, especially has good efficacy, both oral administrations especially, can mash external application again for the furuncle poison that swells and ache.

Cortex Dictamni: the root bark being Rutaceae herbaceos perennial shaggy-fruited dittany Dictamnus dasycarpus Turcz..Nature and flavor: bitter, salty, cold.Return spleen, lung, small intestinal, stomach, urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances." property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow." modern pharmacology research; Cortex Dictamni has antibacterial action: the infusion of in vitro tests 1:4 to multiple pathomycete as trichophyton, Trichophyton concentricunm, oidium schoenleinii; all have inhibitory action in various degree, but have the ether of report this product, ethanol and water extract to be showed no effect to the coccuses such as golden yellow, escherichia coli bacillus pyocyaneus and Mycobacterium phlei.

Herba Schizonepetae: be the dry aerial parts of Labiatae annual herb plant Herba Schizonepetae.Nature and flavor: pungent, bitter, micro-wet.Return lung, Liver Channel.Effect: dispel the wind; Induce sweat; Rash; Hemostasis.Main cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints.This product Chhnang is thoroughly loose, energy dispelling wind for relieving itching, and the loose measles toxin of a surname, can be used for measles without adequate eruption, rubella pruritus.

Radix Saposhnikoviae: be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor: pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For diseases caused by exogenous pathogenic factor exterior syndrome or rubella pruritus.This product slightly warm in nature and not dry, sweet slow and not high, there is the title of " the profit agent in wind medicine ", no matter wind and cold, wind heat exterior syndrome all can be applied.This product also can be used for tetanus, gnathospasma, opisthotonus.Radix Saposhnikoviae controls tetanus, has the effect of expellingging wind and relieving convulsion, and Radix Saposhnikoviae joins the effect that Herba Schizonepetae strengthens expelling pathogenic wind from the body surface.

Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis.Nature and flavor: bitter, cold.GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.This product enters kidney, urinary bladder channel, kind clear damp-heat in lower-JIAO cold in nature.In addition to staphylococcus aureus, Diplococcus pneumoniae, tubercule bacillus has inhibitory action.

Radix Gentianae: be the dry root and rhizome of gentianaceae plant Gentiana manshurica Gentiana manshurica Kitag., Radix Gentianae Gentiana scabra Bunge, G. triflora Gentiana triflora pall or Gentiana rigescens Franch Gentiana rigescens Franch..Nature and flavor: bitter, cold.Return liver, gallbladder meridian.Effect: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.Be used for the treatment of jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, this product large bitter Great Cold, heat clearing and damp drying, outstanding kind liver heat removing gallbladder and damp-heat in lower-JIAO, be the common medicine of damp-heat in lower-JIAO, be used for the treatment of leukorrhagia eczema, swelling of the vulva pudendal pruritus often joins Radix Sophorae Flavescentis, Radix Scutellariae.

Side's solution of the present invention is: Radix Sophorae Flavescentis, Fructus Cnidii heat clearing and damp drying, wind dispelling insecticide in side, Semen Hydnocarpi, Fructus Tribuli promoting blood circulation by removing wind, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Radix Angelicae Sinensis, Flos Carthami enrich blood invigorate blood circulation, eliminating stasis to stop pain, above seven tastes are monarch drug altogether, on the one hand the kidney invigorating of monarch drug bitter cold, lid get its bitter dampness, cold heat extraction also, hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again, reach antipruritic object, Radix Angelicae Sinensis, Flos Carthami heat clearing and blood circulation promoting on the other hand, blood circulation promoting, accelerates the recovery of focus, alleviates the misery of patient.Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, Rhizoma Smilacis Glabrae removing damp-heat, Bombyx Batryticatus expelling wind to relieve convulsion, Cortex Moutan, Cacumen Platycladi clearing away heat and cooling blood, Cortex Phellodendri heat clearing and damp drying, astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of Fructus Schisandrae Chinensis convergence, above seven tastes are ministerial drug altogether, increase effect of monarch drug heat clearing and damp drying, wind dispelling insecticide, and have the effect of clearing away heat and cooling blood, supplementing QI for promoting the production of body fluid, promote the recovery of illing skin.Astringent or styptic treatment for spontaneous sweating, the promoting tissue regeneration and ulcer healing of Os Draconis, Concha Ostreae convergence, the heat clearing away of chrysanthemum powder forimproving wind, Cortex Dictamni heat clearing and damp drying, Herba Schizonepetae, Radix Saposhnikoviae expelling pathogenic wind from the body surface, Fructus Gardeniae clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Rhizoma Alismatis, Radix Gentianae heat clearing and damp drying, a few taste is adjuvant drug altogether above, the health of conditioning patient, strengthens curative effect of medication, promotes that patient recovers.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of heat clearing and damp drying, dispelling wind for relieving itching, clearing away heat and cooling blood, effectively can treat skin pruritus.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Sophorae Flavescentis 15-25 part, Fructus Cnidii 15-25 part, Semen Hydnocarpi 7-17 part, Fructus Tribuli 10-20 part, Radix Rehmanniae 15-25 part, Radix Angelicae Sinensis 15-25 part, Flos Carthami 5-15 part, Fructus Kochiae 15-25 part, Rhizoma Smilacis Glabrae 25-35 part, Bombyx Batryticatus 5-15 part, Cortex Moutan 10-20 part, Cortex Phellodendri 10-20 part, Cacumen Platycladi 10-20 part, Fructus Schisandrae Chinensis 7-17 part, Os Draconis 25-35 part, Concha Ostreae 25-35 part, Flos Chrysanthemi 7-17 part, Cortex Dictamni 10-20 part, Herba Schizonepetae 7-17 part, Radix Saposhnikoviae 7-17 part, Fructus Gardeniae 10-20 part, Rhizoma Alismatis 10-20 part, Radix Gentianae 4-14 part.

Wherein be preferably: Radix Sophorae Flavescentis 20 parts, Fructus Cnidii 20 parts, Semen Hydnocarpi 12 parts, Fructus Tribuli 15 parts, Radix Rehmanniae 20 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Flos Carthami, the Fructus Kochiae 20 parts, Rhizoma Smilacis Glabrae 30 parts, Bombyx Batryticatus 10 parts, Cortex Moutan 15 parts, Cortex Phellodendri 15 parts, Cacumen Platycladi 15 parts, Fructus Schisandrae Chinensis 12 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Flos Chrysanthemi 12 parts, Cortex Dictamni 15 parts, Herba Schizonepetae 12 parts, Radix Saposhnikoviae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Alismatis 15 parts, Radix Gentianae 9 parts.

A kind of preparation method of the Chinese medicine preparation for skin pruritus is as follows:

Step one: according to weight proportion of the present invention, becomes medicated bag by Fructus Cnidii, Semen Hydnocarpi, Fructus Tribuli, the Fructus Kochiae, Fructus Schisandrae Chinensis, Fructus Gardeniae bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, takes Bombyx Batryticatus, Os Draconis, raw oyster powder breakdown mill to 120 mesh sieve, for subsequent use;

Step 3: by weight proportion of the present invention, take Radix Sophorae Flavescentis, Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Smilacis Glabrae, Cortex Moutan, Cortex Phellodendri, Cortex Dictamni, Radix Saposhnikoviae put into marmite and add after step one is soaked and remain cold water, exceed powder 3 ~ 4 li centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3 cm, the medicated bag in joining side Cacumen Platycladi (Cacumen Biotae), Herba Schizonepetae, Rhizoma Alismatis, Radix Gentianae and step one, decocts 30 minutes, finally add Flos Carthami, Flos Chrysanthemi decocts 10 minutes, filter, waste, for subsequent use;

Step 4: twice filtrate in step 3 is merged, adds the powder in step 2 while hot, stir, both the external-use lotion for the treatment of skin pruritus of the present invention.

This pharmaceutical preparation using method is: the medicinal liquid be fried open can fumigate affected part while hot, cleans when water temperature is suitable, about 20 minutes.

Medicine of the present invention has the effects such as heat clearing and damp drying, dispelling wind for relieving itching, clearing away heat and cooling blood, and antipruritic fast, good effect, not easily recur, cheap, healing time is short, adds up according to clinical 180 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 97.8%.

Detailed description of the invention

Embodiment one, Radix Sophorae Flavescentis 15 parts, Fructus Cnidii 15 parts, Semen Hydnocarpi 7 parts, Fructus Tribuli 10 parts, Radix Rehmanniae 15 parts, Radix Angelicae Sinensis 15 parts, 5 parts, Flos Carthami, the Fructus Kochiae 15 parts, Rhizoma Smilacis Glabrae 25 parts, Bombyx Batryticatus 5 parts, Cortex Moutan 10 parts, Cortex Phellodendri 10 parts, Cacumen Platycladi 10 parts, Fructus Schisandrae Chinensis 7 parts, Os Draconis 25 parts, Concha Ostreae 25 parts, Flos Chrysanthemi 7 parts, Cortex Dictamni 10 parts, Herba Schizonepetae 7 parts, Radix Saposhnikoviae 7 parts, Fructus Gardeniae 10 parts, Rhizoma Alismatis 10 parts, Radix Gentianae 4 parts.

Embodiment two, Radix Sophorae Flavescentis 20 parts, Fructus Cnidii 20 parts, Semen Hydnocarpi 12 parts, Fructus Tribuli 15 parts, Radix Rehmanniae 20 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Flos Carthami, the Fructus Kochiae 20 parts, Rhizoma Smilacis Glabrae 30 parts, Bombyx Batryticatus 10 parts, Cortex Moutan 15 parts, Cortex Phellodendri 15 parts, Cacumen Platycladi 15 parts, Fructus Schisandrae Chinensis 12 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Flos Chrysanthemi 12 parts, Cortex Dictamni 15 parts, Herba Schizonepetae 12 parts, Radix Saposhnikoviae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Alismatis 15 parts, Radix Gentianae 9 parts.

Embodiment three, Radix Sophorae Flavescentis 25 parts, Fructus Cnidii 25 parts, Semen Hydnocarpi 17 parts, Fructus Tribuli 20 parts, Radix Rehmanniae 25 parts, Radix Angelicae Sinensis 25 parts, 15 parts, Flos Carthami, the Fructus Kochiae 25 parts, Rhizoma Smilacis Glabrae 35 parts, Bombyx Batryticatus 15 parts, Cortex Moutan 20 parts, Cortex Phellodendri 20 parts, Cacumen Platycladi 20 parts, Fructus Schisandrae Chinensis 17 parts, Os Draconis 35 parts, Concha Ostreae 35 parts, Flos Chrysanthemi 17 parts, Cortex Dictamni 20 parts, Herba Schizonepetae 17 parts, Radix Saposhnikoviae 17 parts, Fructus Gardeniae 20 parts, Rhizoma Alismatis 20 parts, Radix Gentianae 14 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 360 example for medical treatment, patient is divided into observation group and matched group at random, wherein male 186 example, women 174 example, M-F is about 1.06:1, max age 68 years old, minimal ages 3 years old, from 5 days to several years not etc., every basic documents such as two groups of Genders, age, courses of disease are substantially identical, no significant difference (P > 0.05) for the course of disease.

Two, Therapeutic Method

1, observation group is according to Medications Example two of the present invention, and selected preparation method, while hot stifling affected part, and washout when temperature is suitable once a day, 5th is a course for the treatment of.

2, matched group is according to the Chinese medicine lotion for the treatment of skin pruritus in CN 103083599 A, and once, smear during pruritus, within 15 days, be a course for the treatment of, the observation period is 5 days to the patient's every day of cleaning sooner or later.

Three, efficacy assessment standard

1, cure: pruritis disappears, and other clinical symptoms all disappear, and main Physico-chemical tests index is normally.

2, take a turn for the better: pruritis takes a turn for the better gradually, and main Physico-chemical tests index makes moderate progress.

3, do not heal: pruritis does not improve, main Physico-chemical tests index is front unchanged with treatment.

Four, observation group's result statistics

Matched group result is added up

Wherein: total effective rate=cure rate+improvement rate

Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of

Can find that observation group is apparently higher than matched group, illustrates thus by the treatment total effective rate contrasting two groups of patients, Chinese medicine of the present invention has good clinical effectiveness in treatment skin pruritus, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, Zheng, female, 55 years old, leg and arm pruritus are for many years, various medicine is adopted to carry out always administering repeatedly, therapeutic effect is very micro-, be difficult to during pruritus stand, there is obvious scratch at pruritus place, and with blood crusts, after being introduced, come here to go to a doctor, adopt made preparation in the embodiment of the present invention two, and the preparation method preferably selected, washout affected part, after using two courses for the treatment of, patient's pruritus attack times is controlled, and pruritus degree also alleviates to some extent, continue two courses for the treatment of of use, patient's pruritis disappears completely, skin recovers normal, scratch, blood crusts all disappears, for consolidate curative effect, employ again a course for the treatment of, patient does not occur that any discomfort is existing, follow up a case by regular visits to and have no recurrence half a year, recovery from illness.

Case two, Guo, man, 30 years old, suffer from the obstinate pruritus of unknown cause for many years, winter more very, especially winter after a bath after, back, leg more so, through repeatedly out-patient treatment, DeGrain, and often repeatedly, after short-term is antipruritic, will not recur, after being introduced, come here to go to a doctor, adopt made preparation in the embodiment of the present invention two, and the preparation method preferably selected, washout affected part, after using a course for the treatment of, patient's pruritis obviously alleviates, xerosis cutis phenomenon is also eased, continue a course for the treatment of of use, patient often outbreak place skin takes a turn for the better, again there is not the phenomenon of pruritus, follow-up investigation is carried out to patient, pruritus hiemalis symptom does not also recur, recovery from illness.

Case three, Liu, man, 4 years old, entire patient's pruritus, external and multiple Chinese and western drugs for oral administration, all without obvious curative effects, especially night, often therefore cry and scream, father and mother seek medical advice everywhere, have no improvement always, went to a doctor in here afterwards, adopt made preparation in the embodiment of the present invention two, and the preparation method preferably selected, washout affected part, after using a course for the treatment of, patient's pruritis obviously alleviates, and child can sleep sound sleep night, continues a course for the treatment of of use, patient often outbreak place skin takes a turn for the better, pruritis disappears completely, recurrence that so far there are no, recovery from illness.

Claims

1. the Chinese medicine composition for skin pruritus, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Radix Sophorae Flavescentis 15-25 part, Fructus Cnidii 15-25 part, Semen Hydnocarpi 7-17 part, Fructus Tribuli 10-20 part, Radix Rehmanniae 15-25 part, Radix Angelicae Sinensis 15-25 part, Flos Carthami 5-15 part, Fructus Kochiae 15-25 part, Rhizoma Smilacis Glabrae 25-35 part, Bombyx Batryticatus 5-15 part, Cortex Moutan 10-20 part, Cortex Phellodendri 10-20 part, Cacumen Platycladi 10-20 part, Fructus Schisandrae Chinensis 7-17 part, Os Draconis 25-35 part, Concha Ostreae 25-35 part, Flos Chrysanthemi 7-17 part, Cortex Dictamni 10-20 part, Herba Schizonepetae 7-17 part, Radix Saposhnikoviae 7-17 part, Fructus Gardeniae 10-20 part, Rhizoma Alismatis 10-20 part, Radix Gentianae 4-14 part.

2. the Chinese medicine composition for skin pruritus according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Sophorae Flavescentis 20 parts, Fructus Cnidii 20 parts, Semen Hydnocarpi 12 parts, Fructus Tribuli 15 parts, Radix Rehmanniae 20 parts, Radix Angelicae Sinensis 20 parts, 10 parts, Flos Carthami, the Fructus Kochiae 20 parts, Rhizoma Smilacis Glabrae 30 parts, Bombyx Batryticatus 10 parts, Cortex Moutan 15 parts, Cortex Phellodendri 15 parts, Cacumen Platycladi 15 parts, Fructus Schisandrae Chinensis 12 parts, Os Draconis 30 parts, Concha Ostreae 30 parts, Flos Chrysanthemi 12 parts, Cortex Dictamni 15 parts, Herba Schizonepetae 12 parts, Radix Saposhnikoviae 12 parts, Fructus Gardeniae 15 parts, Rhizoma Alismatis 15 parts, Radix Gentianae 9 parts.

3. the Chinese medicine preparation for skin pruritus according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is external-use lotion.

4. the preparation method for the Chinese medicine preparation of skin pruritus, it is characterized in that, preparation method is as follows: step one: according to weight proportion of the present invention, Fructus Cnidii, Semen Hydnocarpi, Fructus Tribuli, the Fructus Kochiae, Fructus Schisandrae Chinensis, Fructus Gardeniae bundle are become medicated bag, be put in water and soak about 45 minutes, filter, for subsequent use; Step 2: by weight proportion of the present invention, takes Bombyx Batryticatus, Os Draconis, raw oyster powder breakdown mill to 120 mesh sieve, for subsequent use; Step 3: by weight proportion of the present invention, take Radix Sophorae Flavescentis, Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Smilacis Glabrae, Cortex Moutan, Cortex Phellodendri, Cortex Dictamni, Radix Saposhnikoviae put into marmite and add after step one is soaked and remain cold water, exceed powder 3 ~ 4 li centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, in residue medicinal residues, add the water of 3 cm, the medicated bag in joining side Cacumen Platycladi (Cacumen Biotae), Herba Schizonepetae, Rhizoma Alismatis, Radix Gentianae and step one, decocts 30 minutes, finally add Flos Carthami, Flos Chrysanthemi decocts 10 minutes, filter, waste, for subsequent use; Step 4: twice filtrate in step 3 is merged, adds the powder in step 2 while hot, stir, both the external-use lotion for the treatment of skin pruritus of the present invention.