CN104258252A - Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof - Google Patents

Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof Download PDF

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Publication number
CN104258252A
CN104258252A CN201410504242.4A CN201410504242A CN104258252A CN 104258252 A CN104258252 A CN 104258252A CN 201410504242 A CN201410504242 A CN 201410504242A CN 104258252 A CN104258252 A CN 104258252A
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weight portion
radix
herba
pharmaceutical composition
powder
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庄志伟
秦立廷
燕磊
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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Abstract

The invention discloses a pharmaceutical composition for treating duck virus hepatitis and a preparation method thereof. The pharmaceutical composition comprises the following raw material medicines: puffball, folium mori, honeysuckle, Rhizoma Cimicifugae, radix bupleuri, Amomum tsao-ko, sweet wormwood, antifebrile dichroa, black soybeans, root of rehmannia, root of common peony, Radix Ophiopogonis, lalang grass rhizome, Cacumen biotae, radix scrophulariae, lithospermum, fructus forsythiae, edible tulip, salvia chinensis, Uniflower Swisscentaury Root, leaf of purpleflower holly, Japanese Cayratia Herb, Saxifraga stolonifera, purslane, phoenix-tail fern and liquorice. The pharmaceutical composition has the beneficial effects that the pharmaceutical composition disclosed by the invention has the main effects of clearing away heat and toxic materials and activating blood circulation and cooling blood as well as auxiliary effects of tonifying qi and strengthening exterior, the body immunity of ill ducks can be improved, the pharmaceutical composition is good in curative effect and low in cost and price and does not have drug tolerance or drug residue, and the state of the illness can be effectively controlled.

Description

A kind of pharmaceutical composition being used for the treatment of duck viral hepatitis and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of pharmaceutical composition being used for the treatment of duck viral hepatitis and preparation method thereof.
Background technology
It is scorching that duck viral hepatitis is called for short duck liver, is cause a kind of of duckling to present with liver the acute deadly infectious disease that hemorrhagic inflammation is feature by virulent duck enteritis virus.Within 1945, at U.S.'s Late Cambrian primary disease, and called after I type duck viral hepatitis, nineteen sixty-five has found duck viral hepatitis II type in Britain, within 1969, has found duck viral hepatitis type III in the U.S..At present, I type is worldwide distribution, and is once reported in the variant that India, Egypt and the U.S. find I type DHV.II type and type III duck viral hepatitis are confined to UK and USA respectively, do not find variation strain.At home, duck viral hepatitis popular for the first time, it is again popular in China that phase early 1980s plays primary disease, and after this, various places epidemic situation is risen one after another, epidemic situation can control by the immunity of duck viral hepatitis I type attenuated vaccine; Since 1997, primary disease occurs more serious popular in certain areas, its epidemic situation fully can not be controlled by standard duck viral hepatitis I type attenuated vaccine, suspects and has I type virulent duck enteritis virus variant to occur.The scorching I type of duck liver causes the Serious Mortality of duckling, and mortality rate is up to 90%, and middle one-tenth duck does not generally fall ill, and the feature of sick duckling is that consciousness is disorderly, and again and again twitch, liver is mottled hemorrhage, gollbladder dilation, and bile color is thin out.
Duck viral hepatitis, virus I-type belongs to Picornaviridae, spherical in shape or class is spherical, diameter at 20-40NM, without cyst membrane, without coagulation, can in duck, chicken, goose embryo allantoic cavity propagation.Viral resistance is strong, can survive the long period in natural environment.DVH virus Type II belongs to Astrovirus, and DVH-III belongs to picornavirus.Without cross-protection between DVH virus three kinds of serotypes.Virulent duck enteritis virus and DHB are without any dependency.
At present, China only finds the scorching I type of duck liver, and the duckling group in 20 ages in days is more common in by primary disease type, and morbidity is anxious, and propagate fast, the course of disease is short, occurs typical nervous symptoms, and the features such as liver severe haemorrhage, all contribute to making preliminary judgement.It should be noted that, in recent years clinically larger age in days duck group or when having made the raw primary disease of the duck mass-sending of immunity inoculation, case often lacks typical pathological change, rarely seen liver enlargement, congestion, surface has tip telangiectasis to break and without serious mottled hemorrhage, easily cause Misdiagnosis, must make a definite diagnosis through identification and isolation of pathogen.Diagnose duck viral hepatitis should also be noted that clinically to differentiate with Riemerellosis Anatipestifer disease, duckling paratyphoid fever, fowl cholera, aspergillosis etc.
Epidemic characteristic: primary disease mainly betides 4 ~ 20 age in days ducklings, and adult duck has resistance, chicken and goose can not natural occurrences.Sick duck and the malicious duck of band are major source of infection, mainly through digestive tract and respiratory tract infection.Feeding and management is bad, is deficient in vitamin and mineral, and duck shed is moist, crowded, and primary disease all can be impelled to occur.Primary disease betides the season of hatching duckling, once occur, propagate very fast in duckling group, sickness rate can reach 100%
Pathological change: 1 ~ 4 day incubation period of primary disease, sudden onset, the course of disease is very brief.Sick just lethargy, do not eat, take action dull, necking down, wing is sagging, and eye semi-closure is comatose state, some appearance diarrhoea.Soon, there is nervous symptoms in sick duck, uneasy, movement disorder, and health swings to side, bipod generation spasm, dead after a few hours.Dead front to palintrope, in opisthotonus posture.The mortality rate of primary disease is variant because of the age, and the duckling within 1 week age can up to 95%, and the duckling in 1 ~ 3 week age is less than 50%; The young duck in 4 ~ 5 week age is substantially not dead.Dissect visible features sexually transmitted disease (STD) to become at liver.Hepatomegaly, in yellowish red color or graniphyric, there are petechia and ecchymosis in surface, and gollbladder dilation is full of bile.Spleen is enlargement sometimes, the piebaldism of outward appearance also similar liver.Most kidney is congested, swelling.Cardiac muscle is as boiled shape.Some case has in pericarditis, air bag micro-yellow transudate and cellulose flocculus.Liver edema, and have many needle points greatly to soybean grain massive hemorrhage point.Gollbladder dilation, is full of bile.Basis of microscopic observation, hepatocyte is vacuolation in initial infection, and Focal necrosis appears in stage, and central nervous system may have vascular cuffing phenomenon.Splenomegaly, in mottling.Renal swelling is swollen, and blood vessel is obvious, in mulberry dendroid.
Primary disease is main infection duck under field conditions (factors), not infected chicken goose, throughout the year, the duck of different cultivars, sex all can infect, healthy duck is infected and popular morbidity by the feedstuff, water, pad grass, vehicle etc. that ill virus hepatitis duck and the malicious duck of band pollute by contact, also by digestive tract and respiratory tract infection, the sickness rate of duckling and case fatality rate are all high, and the duckling case fatality rate in 1 week age can up to 95%, and duck more than 1 monthly age then seldom falls ill death.Because feeding and management is not good at, be deficient in vitamin and mineral, duck shed is dark and damp, and the crowded grade of duck group all can impel primary disease to occur.
Western medical treatment: following several respects should be noted to the control of the scorching I type of duck liver: (1) introduces seedling from healthy chicken flock, strict implement antisepsis system.(2) immune protection: carry out immunity inoculation with duck viral hepatitis I type attenuated vaccine, becomes duck in laying eggs first half of the month, intramuscular injection 1-2 head part/only, and lay eggs mid-term, intramuscular injection 2-4 head part/only.Duckling to go out after shell 1 age in days or 7 age in days subcutaneous injections, 1 part/only.Also passive immunity prevention can be done in 1-2 age in days subcutaneous injection DVH-1 high immunity egg yolk or hyper-immune serum to chickling in epidemic-stricken area.(3) once break out primary disease, isolate disease duck immediately, and thorough disinfection is carried out to duck shed or waters.To morbidity duckling group with standard DVH-1 high immunity yolk antibody injection for curing, 1-1.5 head part/only, attentional manipulation secondary infection simultaneously.(4) bad sick duck group is controlled to employing standard DVH-1 attenuated vaccine or antibody, bad with concurrent infection etc. under prerequisite at eliminating this vaccine and antibody mass, answer isolation identification virus, inquire into about DVH-II type, type III infect and DVH-1 form variation strain infect situation, attempt using local strain to prepare vaccine and antibody, for control.But western medical treatment duck viral hepatitis scheme is single, and types of drugs is limited, and the course for the treatment of is longer, drug residue is comparatively large, untoward reaction is more, and clinical efficacy is undesirable.
Chinese veterinarian thinks, duck viral hepatitis diseases caused by exogenous pathogenic factor six evil, and internal injury liver and gall taste, involve the heart, kidney, causes accumulateing in weakened defensive QI, pathogenic heat, and the cloudy imbalance of battalion is sent out for this reason sick.Chinese traditional treatment duck viral hepatitis, from entirety, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, can for the unified treatment of the duck viral hepatitis of same pattern of syndrome, there is drug effect to go directly focus, short treating period, evident in efficacy, drug residue free, low toxic and side effects, cheap, and the advantage of the immunity of organisms of duck can be increased.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition being used for the treatment of duck viral hepatitis, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have based on heat-clearing and toxic substances removing, promoting blood circulation and cooling blood, benefiting QI for strengthening the superficies is auxiliary effect, and improve the immunity of organisms of ill duck, curative effect is better, prolonged application has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition being used for the treatment of duck viral hepatitis, described pharmaceutical composition comprises following raw medicinal material: Lasiosphaera Seu Calvatia, Folium Mori, Flos Lonicerae, Rhizoma Cimicifugae, Radix Bupleuri, Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, bean curd, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Imperatae, Cacumen Platycladi, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Herba Salviae Chinensis, Radix Rhapontici, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cayatiae Japonicae, Herba Saxifragae, Herba Portulacae, Herba Pteridis Multifidae and Radix Glycyrrhizae.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion and Radix Glycyrrhizae 10-25 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion, Radix Glycyrrhizae 20 weight portion.
Described pharmaceutical composition also comprises Fructus Tritici Levis, Radix Cynanchi Paniculati, Carnis Melis, Radix Ephedrae, Herba avenae fatuae and reddish yellow stilbene.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion, Radix Glycyrrhizae 10-25 weight portion, Fructus Tritici Levis 10-25 weight portion, Radix Cynanchi Paniculati 12-30 weight portion, Carnis Melis 10-20 weight portion, Radix Ephedrae 10-25 weight portion, Herba avenae fatuae 10-20 weight portion and reddish yellow stilbene 10-18 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion, Radix Glycyrrhizae 20 weight portion, Fructus Tritici Levis 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, Carnis Melis 15 weight portion, Radix Ephedrae 15 weight portion, Herba avenae fatuae 18 weight portion and reddish yellow stilbene 14 weight portion.
In order to solve the problems of the technologies described above, present invention also offers a kind of preparation method being used for the treatment of the pharmaceutical composition of duck viral hepatitis, when the dosage form of described pharmaceutical composition is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 82% ~ 93%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.03 ~ 1.10, spraying dry, the inlet temperature 165 ~ 170 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.15 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described pharmaceutical composition is injection, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.11 ~ 8 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 93%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 10 DEG C ~ 15 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 ~ 60 minutes at this, the micron particles of acquisition 0.11 ~ 8 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 93%,
3rd step, gets mixed powder 1 ~ 4g that second step obtains, adds sodium chloride 70 ~ 80g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.2 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention, based on heat-clearing and toxic substances removing, promoting blood circulation and cooling blood, is auxiliary with benefiting QI for strengthening the superficies, can strengthening vital QI to eliminate pathogenic factors, improve the immunity of organisms of ill duck, curative effect is better, has no drug resistance, drug residue free, cost price is cheap, can effective symptom management.
Detailed description of the invention
The present invention follows the principle of heat-clearing and toxic substances removing, promoting blood circulation and cooling blood, provide a kind of pharmaceutical composition being used for the treatment of duck viral hepatitis, comprise following raw medicinal material: Lasiosphaera Seu Calvatia, Folium Mori, Flos Lonicerae, Rhizoma Cimicifugae, Radix Bupleuri, Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, bean curd, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Imperatae, Cacumen Platycladi, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Herba Salviae Chinensis, Radix Rhapontici, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cayatiae Japonicae, Herba Saxifragae, Herba Portulacae, Herba Pteridis Multifidae, Radix Glycyrrhizae.Preferably, also comprise: Fructus Tritici Levis, Radix Cynanchi Paniculati, Carnis Melis, Radix Ephedrae, Herba avenae fatuae and reddish yellow stilbene.
Wherein: Lasiosphaera Seu Calvatia can heat-clearing and toxic substances removing; Folium Mori are good at loose wind heat and let out lung-heat, only can be used for the conjunctival congestion photophobia that wind heat causes, and can clearing away liver-fire, with Flos Lonicerae, Radix Bupleuri, Fructus Forsythiae, Radix Ophiopogonis compatibility with using; Rash delivered by Rhizoma Cimicifugae, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy, with Flos Lonicerae, Fructus Forsythiae, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Bupleuri compatibility with using; Radix Bupleuri is bitter, flat, enters percardium, liver, three burnt, gallbladder meridians, can induce sweat, bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, with Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, Rhizoma Cimicifugae compatibility with using; The light diaphoretic prescription of bean curd for delivering, can deliver heresy outward thoroughly, and the Radix Rehmanniae is sweet, bitter, cold, enters the heart, liver, kidney channel, can clearing away heat and cooling blood, promotes the production of body fluid, with Radix Paeoniae Rubra, Radix Ophiopogonis, Flos Lonicerae, Fructus Forsythiae, Radix Scrophulariae, Rhizoma Imperatae, Cacumen Platycladi compatibility with using; Radix Arnebiae (Radix Lithospermi) is sweet, cold, enters the heart, Liver Channel, can removing heat from blood, removing toxic substances, rash, with Fructus Forsythiae, Flos Lonicerae, Radix Paeoniae Rubra compatibility with using; Flos Lonicerae is sweet, cold, enters lung, stomach, the heart, spleen channel, heat-clearing and toxic substances removing, with Fructus Forsythiae, Radix Paeoniae Rubra, the Radix Rehmanniae, Radix Scrophulariae, Radix Glycyrrhizae compatibility; Pseudobulbus Cremastrae Seu Pleiones enters liver, stomach warp, heat-clearing and toxic substances removing, with Herba Salviae Chinensis compatibility with using; Radix Rhapontici is bitter, cold, can heat-clearing and toxic substances removing, with Rhizoma Cimicifugae, Radix Scrophulariae compatibility; Ilex purpurea Hassk.[I.chinensis Sims can heat-clearing and toxic substances removing, cooling blood for hemostasis, with Herba Cayatiae Japonicae compatibility with using; Herba Saxifragae bitter, acrid, cold, can heat clearing away, removing heat from blood, removing toxic substances; Herba Portulacae heat clearing away, removing toxic substances, removing heat from blood; Herba Pteridis Multifidae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.In addition, Fructus Tritici Levis, Radix Cynanchi Paniculati, Carnis Melis, Radix Ephedrae, Herba avenae fatuae and reddish yellow stilbene can play assosting effect by benefiting QI for strengthening the superficies.Entirely put compatibility reasonable, rigorous, clinical efficacy is remarkable.
Now each taste medicine is described below:
Lasiosphaera Seu Calvatia: pungent, flat, nontoxic.Main be used as local hemostatic, doublely control throat pain, aphonia etc.Traumatic hemorrhage, epistaxis, postextraction hemorrhage: Lasiosphaera Seu Calvatia tears epithelium off, gets inner sponge floss sample thing compressing bleeding part or fills in nostril, filling gingiva place, have good hemostatic function.Carbuncle furuncle: Lasiosphaera Seu Calvatia spore powder, is in harmonious proportion with Mel and applies affected part.Chilblain: first embathed by affected part warm water, makes local rubescent, wipe dry after to apply ointment or plaster Lasiosphaera Seu Calvatia by affected part size.Lasiosphaera fenzlii Reics has to oral cavity hemorrhagic illness usefulness of significantly stopping blooding, not second to starch sponge or gelfoam, also effective to epistaxis.Lasiosphaera fenzlii Reics decoct has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae, also has inhibitory action to minority pathomycete.
Folium Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc.In addition Flos Lonicerae also have function of gallbladder promoting to protect the liver, antioxidation, blood fat reducing, the effect such as central excitation.
Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp." property of medicine opinion ": " control little eclampsia, infantile convulsion, the hot disease of seasonal epidemic pathogens.Can control the swollen pain of ability to speak wind NI, root of the tooth floats rotten stench, pyretic toxicity pus and blood.Except cardiopulmonary pathogenic wind toxic heat is obstructed and constipated, aphtha, unhappy.Treat carbuncle, smallpox; Decocting silk floss is stained with and is wiped in skin ulcer." Compendium of Material Medica: " speckle removing rash, clots absorbing blood are controlled sun and are fallen into dizzy fortune, the empty pain of the breast side of body, heavy after chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot." function heat-clearing and toxic substances removing, rash.Not smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome is thoroughly sent out, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, " Bencao Tujing " carries: " between (Radix Bupleuri) modern passs, Shan, rivers and lakes, shortcut all has it, with silver-colored state person for winning.Life in February Seedling, very fragrant, stem is livid purple, and leaf is slightly purple like Folium Bambusae ... July opens Hemerocallis citrina Baroni ... root redness of the skin or complexion is strong like Radix Peucedani.Reed head has red hair as Mus tail, and only nest elder is good.August in February adopts root." tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Function: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly: the heating that cures cold, cold and heat deficient fever.Children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia.Radix Bupleuri volatile oil has trivial solution heat effect to the caused heating such as typhoid fever, paratyphoid fever vaccine, escherichia coli liquid, fermented milk, yeast, and animal normal body temperature can be made to decline.To ankle joint caused by multiple proinflammatory agent, swollen and desmoplastic inflammation all has inhibitory action.
Fructus Tsaoko: acrid in the mouth, warm in nature, nontoxic; Enter spleen channel, stomach warp.Compendium of Material Medica: " Fructus Tsaoko, use same with the Rhizoma Anemarrhenae, controls subtertian malaria cold and heat, and get the evil of its monoyin and monoyang without inclined victory, it is cold that lid Fructus Tsaoko controls lunar only victory, and the fire that Rhizoma Anemarrhenae Zhi Yangming solely wins also." " herbal classic is met former ": " except cold, dampness, dissipating depression of QI, relieving dyspepsia, expectorant on sharp diaphragm, separates wheaten food, fish, all poison of meat." dampness is except cold, eliminate the phlegm preventing the attack (or recurrence) of malaria, and help digestion relieving dyspepsia.Cure mainly malaria, phlegm retention feeling of fullness, coldness and pain in the epigastrium, regurgitation, vomiting, dysentery, food stagnation.
Herba Artemisiae Annuae: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Function: clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) falls apart thoroughly, and the kind the moon that makes divides a latent heat thoroughly to reach outer faling apart, and is fever due to yin deficiency key medicine, has expelling summer-heat in addition, cut cruel merit.Arteether extracts neutral fraction and its rare alcohol extractum to Mus malaria, monkey malaria and people's malaria all in remarkable Antimalarial.Decocting liquid has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.Ether extract, rare alcohol extractum and arteannuin to Mus malaria, monkey malaria, people's malaria all in remarkable Antimalarial.Arteannuin also can decreased heart rate, suppresses myocardial contraction, reduces coronary flow.
Radix Dichroae: nature and flavor are pungent, cold, bitter; Return lung, liver, spleen, heart channel." Bencao Tujing ": " Radix Dichroae, modern Jingxi district, Huaihe River, Zhejiang, prefecture, state, Hunan also have it.Haizhou person of going out, leaf is like Folium catalpae bungei, and eight chis, have premium white, sub green color, little like mountain chinaberry.Picking leaves in May, August adopts root, dries in the shade.This two taste is wanting most for the treatment of malaria." " property of medicine opinion ": " control all malarias, saliva of spitting, cold removing heat, tumor wart under item." cure mainly phlegm retention in the heart; Malaria.Modern study shows that Radix Dichroae has Antimalarial, anti-ameba effect, refrigeration function etc.
Bean curd: this product is seed (i.e. Semen sojae atricolor) the germination person of legume soybean black.Sweet, flat; Enter spleen, stomach warp.For hygropyrexia, heat-damp in summer from the beginning of, heating, aversion to cold, heavy sensation of the body, uncomfortable in chest, greasy fur, retention of damp-heat in the interior, fever and irritability, uncomfortable in chestly not relax, the disease such as heavy sensation of the body bodily pain.The light diaphoretic prescription of bean curd for delivering, thoroughly can deliver heresy outward, interior water of eliminating wets, and has table disease person concurrently for damp and hot.Bean curd is also good at sensible a surname profit, for the humidifier fever such as hygropyrexia, heat-damp in summer.
The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.
Radix Paeoniae Rubra: nature and flavor is bitter, cold; Return Liver Channel." herbal classic ": " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " promoting the circulation of blood, removing blood stasis with potent drugs, loose clot, only stomachache, moves back heat in blood, attacks carbuncle skin ulcer, control mange for purgation of spleen excess fire, sending down the abnormal ascending QI." " property of medicine opinion ": " control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, control evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." energy blood stasis removing, pain relieving, removing heat from blood, detumescence.Can be used for controlling the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.For epidemic febrile disease, heat enters nutrient blood, heating, crimson tongue, body send out macule, and bleeding due to blood-heat etc., also can be used for amenorrhea, traumatic injury, the stagnation of QI-blood cards such as sore and toxic.
Radix Ophiopogonis: sweet, the micro-hardship of property, is slightly cold; GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, can be used for sore throat pharyngalgia, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation etc.Clear the moon of supporting lung stomach goes heart use more, and YIN nourishing clears away heart-fire the use that connects with the heart more.These product are sweet cold clear and rich, and be apt to control deficiency of stomach-Yin, dry tongue is thirsty, indigestion and loss of appetite not hungry card such as grade.In addition, also availablely deficiency of YIN dryness of the intestine is controlled, constipation person.Modern study shows, can improve immunologic function Radix Ophiopogonis, various bacteria be had to inhibitory action, can strengthen pituitary adrenal system function, improve organism adaptation ability.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin called between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, so fine, withered to the autumn, and its root, to pure white, also very sweet and refreshing, adopted root June and used." Compendium of Material Medica: " emesis is defeated in battle all blood, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, be mainly used in haematemesis, hemoptysis that lung stomach has accumulated heat, damp invasion of lower energizer pents up the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, the cards such as jaundice due to damp-heat.
Cacumen Platycladi: " Amplification on Materia Medica addendum ": " how dry its property is for Cacumen Platycladi (Cacumen Biotae), the key medicine of nourishing YIN, of a specified duration it, large strengthening the spleen soil, to grow its lung." " Bencao Jingshu ": " and Cacumen Platycladi, bitter in the mouth and tepor, justice should and in being slightly cold, therefore in vain red in all metrorrhagias of winner.With regard to QI invigorating of making light of one's life by commiting suicide, make us resistance to cold and summer-heat, be then slightly same as the property of cypress reality.Only granulation promoting is dried numbness, be its length of solely arrogating to oneself also." " Mingyi Bielu ": " main haematemesis, epistaxis, dysentery blood, metrorrhagia are in vain red.To make light of one's life by commiting suicide QI invigorating, make us resistance to cold and summer-heat, numbness of drying, granulation promoting." in addition, still have antitussive, eliminate the phlegm, relieving asthma, the effect such as calm.Experiment in vitro shows, these product all have inhibitory action to staphylococcus aureus, micrococcus catarrhalis, dysentery bacterium, Bacillus typhi, diphtheria corynebacterium etc.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel." detailed outline ": " kidney water is injured, Kidney-Yin fall, lonely positive unrooted, and send out as fire is sick, method should strengthen water with fire processed, therefore Radix Scrophulariae and the same merit of Radix Rehmanniae.Its scrofula that disappears also is loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." " Records of Tradition Chinese and Western Medicine in Combination ": " many liquid cool in nature was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." " Japan hanako materia medica ": " control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strains, and the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, effect of YIN nourishing, cure mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel, Compendium of Material Medica: " Radix Arnebiae (Radix Lithospermi), its merit is longer than removing heat from blood and promoting blood circulation, sharp intestine and small intestine.Therefore varioliform exanthema is for going out out, heat in blood poison is contained, and stool closes puckery person and with it, should go out and the purple melena person of cutting also can use.If go out and red work, and white fall into convenience person, cut compatibility and incompatibility of drugs it." " Bencao Jingshu ": " Radix Arnebiae (Radix Lithospermi) is the key medicine of removing heat from blood, therefore the gas of main trusted subordinate's pathogenic heat." be mainly used in that heat in blood poison is contained, macule purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc.The ether of Radix Arnebiae (Radix Lithospermi), water, ethanol extraction all have certain antiinflammatory action.Oral refrigeration function rabbit experiment heat pyrexia being had to mitigation of Radix Arnebiae (Radix Lithospermi) decoct, its extract and pigment composition also have slight refrigeration function.
Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian." property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Tang Materia Medica: " Fructus Forsythiae has two kinds, sticks up greatly, Herba Hyperici Erecti.Stick up greatly leaf long and narrow, as Herba Stachydis Japonicae, brightly yellowish lovely, give birth to wetland, work, like the Chinese toon person of not opening in fact, sticks up outstanding grass as room.On the raw hilllock of its Herba Hyperici Erecti is former, Ye Huashi is all carefully little like sticking up greatly, and mountain people from south also uses it.Only with sticking up son greatly under modern capital, without stem flower also." pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, be the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, symptom, its bacteriostasis and the Flos Lonicerae broadly similar such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.
Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool.Dispersing swelling and dissipating binds, reduces phlegm, heat-clearing and toxic substances removing.Control carbuncle furuncle and phyma, laryngopharynx swelling and pain, sore throat, scrofula.Supplement to the Herbal: " vinegar mill applies it for main carbuncle skin ulcer fistula, scrofula tuberculosis etc." Compendium of Material Medica: " main furuncle swells, counteracting toxic substances broken skin.Separate all poison, snakeworm, mad dog wound.", carbuncle furunculosis, scrofula swollen to acute mastitis go through tuberculosis, for oral administration, external application, all can apply.For the fit applications such as esophageal carcinoma, breast carcinoma, normal and Semen Impatientis, Rhizoma Pinelliae Preparata, Eupolyphaga Seu Steleophaga, Herba Salviae Chinensis; For lymph tumor, excision of benign breast, normal and Thallus Laminariae (Thallus Eckloniae), Sargassum, Spica Prunellae, resemble the fit applications such as shellfish.
Herba Salviae Chinensis: acrid in the mouth, hardship, cold nature.Blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating.Cure mainly dysmenorrhea, damp-heat vaginal discharge, liver cirrhosis, hepatocarcinoma, have blood in stool, jaundice due to damp-heat, rheumatic ostalgia, traumatic injury wound is swollen.All herbal medicine, Jiangsu one is with that to be used for treating the liver scorching, facial paralysis, mastitis, carbuncle furuncle, the disease such as dysmenorrhea and osteodynia, and Jiangjin, Sichuan root is steep in wine for oral administration, can regulating menstruation and activating blood, and Guangxi is used for curing rheumatism and skin ulcer scabies.Attached side's Herba Salviae Chinensis is done medicinal, and foresight is in " the deficient beautiful letter of gold " of Zhang Zhongjing, and user was less afterwards.But common effect still recorded by each book.Think that it is the medicine of " liver blood system ", " therefore controlling all disorders of blood ".
Radix Rhapontici: bitter in the mouth is salty, cold; Enter stomach, large intestine channel.Shennong's Herbal: " Radix Rhapontici bitter in the mouth is salty-cold.Main skin heat, evil wound, cellulitis hemorrhoid, lower milk ... one wild blue.Raw mountain valley." " Bencao Jingshu ": " and Radix Rhapontici, hardship can be let out down, salty can softening the hard mass, cold can heat extraction, the cold and medicine of tonneau is also.Therefore main skin heat, malignant boil cellulitis hemorrhoid, arthralgia chiefly caused by damp pathogen, lower milk." heat-clearing and toxic substances removing, evacuation of pus is subsided a swelling, and eliminating carbuncle, stimulating milk secretion, relaxing muscles and tendons is promoted blood circulation.Swell and ache for acute mastitis, carbuncle carbuncle on the back, scrofula sore, galactostasis, arthralgia chiefly caused by damp pathogen contracture, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.Radix Rhapontici water logging agent (1:3), has inhibitory action in various degree to dermatophytess such as being permitted blue achorion, star-shaped nocardia in vitro. and Radix Rhapontici can be used for again various tumor clinically.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool." Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out." Ilex purpurea Hassk.[I.chinensis Sims controls cough due to lung-heat, laryngopharynx swelling and pain, pyretic stranguria, dysentery.This product bitter cold, is good at purte the white and relieving heat toxin clearly.Stop up on lung-fire, cough, pharyngalgia and anemopyretic cold; Or invade under pyretic toxicity, the puckery pain of dribbling urination, dysentery person, namely alone this product imitates.
Herba Cayatiae Japonicae: sour, bitter, cold, nontoxic.After one's own heart, liver, stomach warp.Tang Materia Medica: " main air is scorchingly hot swollen, and You Dan, snakebite, smashes and apply and drink juice." " vegetation is side just ": " heat-clearing and toxic substances removing, be coated with sore, disappear tuberculosis, and nine fictitious gas infectionss, tonification is deficient." heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, diuresis.For laryngopharynx swelling and pain, furuncle and phyma, carbuncle, furuncle, dysentery, hematuria, nebulousurine, traumatic injury, venom.Herba Cayatiae Japonicae injection 1%, 10% concentration, proves all have inhibitory action to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, card ground coccus, streptococcus pneumoniae, hemophilus influenza with Plating.Herba Cayatiae Japonicae injection 1:10,1:100 dilution mixes with virus injects chick embryo allantois intracavity, and the anti--77-56-E2 in popularity cold virus A3/ Shanghai and capital section 68-1 strain have obvious inhibitory action.
Herba Saxifragae: micro-bitter, acrid, cold; Enter lung, spleen, large intestine three warp.Compendium of Material Medica: " control pestilence, beat wine clothes.Vomiting and diarrhea people is used in life, and ripe use is emesis profit then.Control again Ting ear, smash juice and drip it." " the SHENGCAO property of medicine standby want ": " control in ear sudden high fever poison, redness is suppurated pain, beats juice instillation ear, or adds Borneolum Syntheticum and dissipate and heal." dispel the wind, heat clearing away, removing pathogenic heat from blood and toxic substance from the body.Control rubella, eczema, otitis media, erysipelas, cough, spit blood, lung abscess, metrorrhagia, haemorrhoids.Isolated frog heart drips fresh juice filtrate or the 1:1 ethanol extract 0.01ml of Herba Saxifragae squeezing, all shows certain cardiotonic.Anesthetized dog and conscious rabbits intravenous injection Herba Saxifragae ethanol extract 1ml/kg, present obvious diuresis.
Herba Portulacae: cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Compendium of Material Medica: " loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property." " Kaibao Bencao ": not " clothes not white all the year round.Control carbuncle skin ulcer, kill parasites.Raw juice of smashing takes, and when disliking thing under profit, removes tapeworm." function heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.
Herba Pteridis Multifidae: light, micro-hardship is cool." the SHENGCAO property of medicine is standby to be wanted ": " wash infantile malnutrition, furuncle, hemorrhoid, loose poison, applies skin ulcer.Control Serpentis and sting all poison, knife injury, energy hemostasia and promoting granulation, spring juice rectification clothes, slag applies affected part.Grinding into powder harvests and store controls pain due to disorder of QI." " conventional Chinese herbal medicine handbook ": " heat clearing away, dampness removing, removing heat from blood.Control bacillary dysentery, enteritis, fever caused by exogenous pathogens, urinary tract infection, leucorrhea, parotitis, furuncle, eczema." clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald.
Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " is said: " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " in main abdomen, cold type of pain, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Empty and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, have good effects to chronic adrenocortical hypofunction; Glycyrrhiza preparation can promote stomach mucus to be formed and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, be usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.
Fructus Tritici Levis: property sweet-salty is cool.1. " detailed outline ": " sweet salty, cold, nontoxic." 2. essentials of Matea Medica: " is salty, cool." cure mainly and control hectic fever due to YIN-deficiency consumptive fever, only spontaneous sweating.1. " book on Chinese herbal medicine covers bamboo fish trap ": " hold back sweating due to debility." 2. " detailed outline ": " QI invigorating heat extraction, only spontaneous sweating, hectic fever due to YIN-deficiency deficiency-heat, married woman's consumptive fever." 3. " modern Practical Chinese medicinal ": " reinforcing the heart, only tired, heat extraction, arresting sweating, diuresis."
Radix Cynanchi Paniculati: nature and flavor are pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be nontoxic." function cures mainly analgesia, cough-relieving, inducing diuresis to remove edema, promoting blood circulation and detoxication.Treat for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.
1, for various pain diseases such as rheumatic arthralgia, lumbago, traumatic injury pain, abdominal pain, toothache.Radix Cynanchi Paniculati has good wind-expelling pain-stopping effect, is widely used for the various pain diseases caused by rheumatism, cold coagulation, the stagnation of QI, blood stasis.In recent years also for postoperative pain and cancerous protuberance pain, there is certain analgesic effect.Can apply by single, or with demonstrate,proving the relevant medicine of compatibility.2, by dermatosiss such as eczema, rubella wheal, stubborn dermatitis.This product has dispelling wind for relieving itching effect.Can be alone for oral administration or decoct soup washout, also can the medicine of the eliminating damp-heat such as compatibility Radix Sophorae Flavescentis, the Fructus Kochiae, Cortex Dictamni.In addition, this product can also antidote against snake bite, and controls venom.Can with Herba Lobeliae Chinensis with using for oral administration or external.1. " herbal classic ": " evil gas, pyrexial malaria, " " main note easily dies, and crys, sad, dimly for main diseases due to noxious agents produced by various parasites, epidemic." 2. " not Lu ": " QI invigorating." 3. " the SHENGCAO property of medicine is standby to be wanted ": " infusing drugs in wine, except rheumatism." 4. " simple and easy medical herbs ": " controls traumatic injury, bones and muscles pain." 5. " south of the Five Ridges gather medicinal herbs record ": " controls infant abdominal distention, and blue veins occurs.Control bite by rabid dog again." 6. " will planted by middle traditional Chinese medicines ": " controls all acute filthy disease and belly pain, peratodynia, food stagnation, cholera." 7. " Nanjing medicinal herbs among the people ": " Seedling, infusing drugs in wine is gargled, and can control toothache." 8. " Guizhou side's medicine among the people collection ": " restores menstrual flow and invigorates blood circulation.Control red collapsing, leucorrhea." 9. " Fujian traditional herbal medicine ": " QI invigorating, by phoenix, strong waist rattan, antidotes against snake bite." 10. Guangzhou army " conventional Chinese herbal medicine handbook ": " wind-expelling pain-stopping, removing toxic substances and promoting subsidence of swelling, promoting the flow of QI in the collateral by warming the meridian.Control venom, rheumatic ostalgia, heart peratodynia, treating swelling and pain by traumatic injury, herpes zoster, cirrhotic ascites, menoxenia, dysmenorrhea." " Jilin Chinese herbal medicine ": " diuresis, strong, sedation-analgesia, dissipating blood stasis of dispeling cold, antidotes against snake bite, dredging collateral and blood.Control beriberi, edema, ascites, distension, abdominal pain due to cold."
Carnis Melis: nature and flavor " detailed outline ": " sweet acid, flat, nontoxic." returning through " book on Chinese herbal medicine brief points ": " enters meridian of Hand-TAI YIN." 1. function cures mainly " Bencao Tujing ": " controls infantile emaciation, and that eats kills ascarid." 2. Wang Ying " food book on Chinese herbal medicine ": " invigorating the spleen and replenishing QI, pleasant." 3. " detailed outline ": " merit and Included-in-the-Appendices are together."
Radix Ephedrae: nature and flavor are " detailed outline " 1.: " sweet, flat, nontoxic.It is " 2. " book on Chinese herbal medicine is just ": " sweet and slightly bitter taste, micro-puckery." function cures mainly and controls body empty spontaneous perspiration, night sweat.1. TAO Hong-Jing: " hidroschesis, Xia Yue powder of mixing uses it." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " hidroschesis, shows gas in fact, Gu empty, and the lung qi that disappears, globus hystericus." 3. " Traditional Chinese Medicine in Sichuan will ": " arresting sweating and strengthening superficial resistance.Control spontaneous perspiration due to yang insufficiency, night sweat due to yin deficiency."
Herba avenae fatuae: nature and flavor are sweet; Flat.Function cures mainly astringing to arrest bleeding; Strengthening superficial resistance to stop perspiration.Main haematemesis; Have blood in stool; Metrorrhagia; Spontaneous perspiration; Night sweat; Leucorrhea.
Reddish yellow stilbene: nature and flavor are sweet; Temperature.Return careful; Lung; Spleen; Kidney channel.Function cures mainly invigorating QI to consolidate the body surface resistance; Diuresis; Expelling pus and toxin by strengthening QI; Promoting tissue regeneration and ulcer healing.Cure mainly cardiopalmus of breathing hard; Asthenia; Weak; Spontaneous perspiration; Night sweat; Chronic diarrhea; Proctoptosis; Uterine prolapse; Body is impractical swollen; Chronic nephritis; Carbuncle difficulty is burst; Or burst do not hold back for a long time.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion and Radix Glycyrrhizae 20 weight portion.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 82%, be heated to boiling reflux 2 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.03, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 70 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 times and 0.15 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 2 pharmaceutical composition 2
Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion, Radix Glycyrrhizae 20 weight portion, Fructus Tritici Levis 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, Carnis Melis 15 weight portion, Radix Ephedrae 15 weight portion, Herba avenae fatuae 18 weight portion and reddish yellow stilbene 14 weight portion.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.11 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.11 μm of volume average particle size, described mixed powder powder rate be at least 93%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 hours under the condition of 15 DEG C, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 55 minutes at this, the micron particles of acquisition 0.11 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.11 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 93%,
3rd step, gets the mixed powder 2g that second step obtains, adds sodium chloride 70g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.2 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
Toxicity trial
Trial drug is 1.: by Lasiosphaera Seu Calvatia 20g, Folium Mori 25g, Flos Lonicerae 30g, Rhizoma Cimicifugae 15g, Radix Bupleuri 20g, Fructus Tsaoko 15g, Herba Artemisiae Annuae 18g, Radix Dichroae 7g, bean curd 28g, Radix Rehmanniae 15g, Radix Paeoniae Rubra 16g, Radix Ophiopogonis 14g, Rhizoma Imperatae 16g, Cacumen Platycladi 15g, Radix Scrophulariae 18g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Forsythiae 20g, Pseudobulbus Cremastrae Seu Pleiones 8g, Herba Salviae Chinensis 18g, Radix Rhapontici 16g, Ilex purpurea Hassk.[I.chinensis Sims 18g, Herba Cayatiae Japonicae 18g, Herba Saxifragae 6g, Herba Portulacae 15g, Herba Pteridis Multifidae 16g and Radix Glycyrrhizae 20g is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 times is the ethanol of 90%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution, first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, the dry cream obtained is placed in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders, the starch relative to its quality 2 times will be added in the micropowders of acquisition, mixing, obtain powder.
Trial drug is 2.: get Lasiosphaera Seu Calvatia 20g, Folium Mori 25g, Flos Lonicerae 30g, Rhizoma Cimicifugae 15g, Radix Bupleuri 20g, Fructus Tsaoko 15g, Herba Artemisiae Annuae 18g, Radix Dichroae 7g, bean curd 28g, Radix Rehmanniae 15g, Radix Paeoniae Rubra 16g, Radix Ophiopogonis 14g, Rhizoma Imperatae 16g, Cacumen Platycladi 15g, Radix Scrophulariae 18g, Radix Arnebiae (Radix Lithospermi) 15g, Fructus Forsythiae 20g, Pseudobulbus Cremastrae Seu Pleiones 8g, Herba Salviae Chinensis 18g, Radix Rhapontici 16g, Ilex purpurea Hassk.[I.chinensis Sims 18g, Herba Cayatiae Japonicae 18g, Herba Saxifragae 6g, Herba Portulacae 15g, Herba Pteridis Multifidae 16g, Radix Glycyrrhizae 20g, Fructus Tritici Levis 15g, Radix Cynanchi Paniculati 20g, Carnis Melis 15g, Radix Ephedrae 15g, purple casserole is put in Herba avenae fatuae 18g and reddish yellow stilbene 14g mixing, add clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use, residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour, be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, filtrate a and filtrate b is mixed to get decoction.
Test method is 1.: application NIH mice 20, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 10, i.e. matched group and administration group, fasting 12 hours before experiment; 1. trial drug is dissolved in water, (concentration is 6.5g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.5g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.
Test method is 2.: application NIH mice 20, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 10, i.e. matched group and administration group, fasting 12 hours before experiment; 2. trial drug is carried out gavage, and gavage volume is 5ml/kg(and unit dosage form is 35.0g crude drug/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore pharmaceutical composition acute toxicity of the present invention is low, clinical drug safety.
Contrast test
Purchase the duckling 5 batches that 1 age in days cultivates without the Shandong Province of maternal antibody, totally 1000.1st batch 80, for viral kill quantitative determination.2nd batch 200, be divided into 5 groups at random, often organize 40, be i.e. embodiment 1 group, embodiment 2 groups, western medicine group, infection matched group and blank group.
Virulent duck enteritis virus serum I type is provided by China Veterinery Drug Inspection Office.
Trial drug: embodiment 1 granule, embodiment 2 injection and Western medicine amantadine content are the oral liquid of 0. 2 mg/mL.
Minimum lethal dose measures: with 1 age in days without maternal antibody duckling 80, raise to the 7th day, carry out minimum lethal dose mensuration with the DHV allantoic fluid through Embryo Gallus domesticus rejuvenation.Result of the test minimum lethal dose is that allantoic fluid 100 times dilution 0 .22mL/ is only oral.
Inoculation: with 7 ages in days without maternal antibody duckling, according to minimum lethal dose measurement result, carry out formal inoculation test.Blank group is virus inoculation allantoic fluid not, and the oral minimum lethal dose after measured of all the other ducks is the viral allantoic fluid 0 .22 mL of 1: 100 dilution.
Treatment: embodiment 1 group is treated with embodiment 1 granule at virus inoculation for 2 days afterwards, gavages 5g at every turn, every day 2 times, is used in conjunction 5 d.
Embodiment 2 groups uses each intramuscular injection 2.5mL of embodiment 2 injection at virus inoculation after 2 days, every day 2 times, be used in conjunction 5 d.
Western medicine group 2 days is the oral liquid of 0. 2 mg/mL with amantadine content at virus inoculation afterwards, gavages 2.5 mL at every turn, is used in conjunction 5 d.
Blank group need not any Drug therapy.
Infecting matched group need not any Drug therapy.
Result of the test
After inoculation virulent duck enteritis virus, morbidity duckling occurs that symptom is as follows: sick duck finding symptom mainly contains: spirit is depressed, appetite declines gradually, feather is thick disorderly unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, row's yellow or celadon loose stool, on one's deathbed there is nervous symptoms before in the sick duck of part, there is the symptoms such as opisthotonus, get the tissue smear such as duck liver, spleen of dying of illness, with the dialister bacterium of the dense dye in visible the two poles of the earth after Wright Stain dyeing, namely be judged as duck viral hepatitis, be namely judged as duck viral hepatitis.
Record the survival rate after postvaccinal morbidity number and treatment and mortality rate.See table 1
As can be seen from Table 1, after inoculation infectious hepatitis of duck virus, all there is incidence in various degree in embodiment 1 group, embodiment 2 groups, western medicine group and infection matched group.Through treatment, the treatment survival rate of embodiment 1 group and embodiment 2 groups is all higher than western medicine group, more higher than infection matched group.Therefore, can learn, pharmaceutical composition of the present invention, treatment duck viral hepatitis, effective, determined curative effect.
Model case: Heze city of Shandong province duck raiser, cultivation has 800 ducklings, occurs duck viral hepatitis symptom: spirit is depressed, appetite declines gradually, feather is thick disorderly unglazed, instability of gait, two wing shakes, dyspnea, diarrhoea, the green loose stool of ash discharge, gets the tissue smear such as duck liver, spleen of dying of illness, with the dialister bacterium of the dense dye in visible the two poles of the earth after Wright Stain dyeing, be namely judged as duck viral hepatitis.Select wherein ill young goose 300, adopt the injection of embodiments of the invention 2 to carry out intramuscular injection, every day 2 times, treat 5, survival healing 298 ducklings, dead 2, survival rate 99.33%.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. be used for the treatment of the pharmaceutical composition of duck viral hepatitis, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: Lasiosphaera Seu Calvatia, Folium Mori, Flos Lonicerae, Rhizoma Cimicifugae, Radix Bupleuri, Fructus Tsaoko, Herba Artemisiae Annuae, Radix Dichroae, bean curd, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Ophiopogonis, Rhizoma Imperatae, Cacumen Platycladi, Radix Scrophulariae, Radix Arnebiae (Radix Lithospermi), Fructus Forsythiae, Pseudobulbus Cremastrae Seu Pleiones, Herba Salviae Chinensis, Radix Rhapontici, Ilex purpurea Hassk.[I.chinensis Sims, Herba Cayatiae Japonicae, Herba Saxifragae, Herba Portulacae, Herba Pteridis Multifidae and Radix Glycyrrhizae.
2. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to claim 1, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion and Radix Glycyrrhizae 10-25 weight portion.
3. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion and Radix Glycyrrhizae 20 weight portion.
4. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Fructus Tritici Levis, Radix Cynanchi Paniculati, Carnis Melis, Radix Ephedrae, Herba avenae fatuae and reddish yellow stilbene.
5. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 10-30 weight portion, Folium Mori 15-35 weight portion, Flos Lonicerae 12-35 weight portion, Rhizoma Cimicifugae 10-25 weight portion, Radix Bupleuri 12-30 weight portion, Fructus Tsaoko 10-32 weight portion, Herba Artemisiae Annuae 10-28 weight portion, Radix Dichroae 7-13 weight portion, bean curd 15-38 weight portion, Radix Rehmanniae 10-25 weight portion, Radix Paeoniae Rubra 12-26 weight portion, Radix Ophiopogonis 10-24 weight portion, Rhizoma Imperatae 10-26 weight portion, Cacumen Platycladi 10-25 weight portion, Radix Scrophulariae 12-38 weight portion, Radix Arnebiae (Radix Lithospermi) 10-25 weight portion, Fructus Forsythiae 13-28 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8-12 weight portion, Herba Salviae Chinensis 12-28 weight portion, Radix Rhapontici 13-26 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 10-28 weight portion, Herba Cayatiae Japonicae 12-28 weight portion, Herba Saxifragae 6-14 weight portion, Herba Portulacae 10-20 weight portion, Herba Pteridis Multifidae 12-26 weight portion, Radix Glycyrrhizae 10-25 weight portion, Fructus Tritici Levis 10-25 weight portion, Radix Cynanchi Paniculati 12-30 weight portion, Carnis Melis 10-20 weight portion, Radix Ephedrae 10-25 weight portion, Herba avenae fatuae 10-20 weight portion and reddish yellow stilbene 10-18 weight portion.
6. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to any one of claim 1-5, it is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Lasiosphaera Seu Calvatia 20 weight portion, Folium Mori 25 weight portion, Flos Lonicerae 30 weight portion, Rhizoma Cimicifugae 15 weight portion, Radix Bupleuri 20 weight portion, Fructus Tsaoko 15 weight portion, Herba Artemisiae Annuae 18 weight portion, Radix Dichroae 7 weight portion, bean curd 28 weight portion, the Radix Rehmanniae 15 weight portion, Radix Paeoniae Rubra 16 weight portion, Radix Ophiopogonis 14 weight portion, Rhizoma Imperatae 16 weight portion, Cacumen Platycladi 15 weight portion, Radix Scrophulariae 18 weight portion, Radix Arnebiae (Radix Lithospermi) 15 weight portion, Fructus Forsythiae 20 weight portion, Pseudobulbus Cremastrae Seu Pleiones 8 weight portion, Herba Salviae Chinensis 18 weight portion, Radix Rhapontici 16 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18 weight portion, Herba Cayatiae Japonicae 18 weight portion, Herba Saxifragae 6 weight portion, Herba Portulacae 15 weight portion, Herba Pteridis Multifidae 16 weight portion, Radix Glycyrrhizae 20 weight portion, Fructus Tritici Levis 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, Carnis Melis 15 weight portion, Radix Ephedrae 15 weight portion, Herba avenae fatuae 18 weight portion and reddish yellow stilbene 14 weight portion.
7. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 82% ~ 93%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.03 ~ 1.10, spraying dry, the inlet temperature 165 ~ 170 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.15 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
8. the pharmaceutical composition being used for the treatment of duck viral hepatitis according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.11 ~ 8 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 93%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 10 DEG C ~ 15 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 ~ 60 minutes at this, the micron particles of acquisition 0.11 ~ 8 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 93%,
3rd step, gets mixed powder 1 ~ 4g that second step obtains, adds sodium chloride 70 ~ 80g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.2 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
9. the preparation method being used for the treatment of the pharmaceutical composition of duck viral hepatitis as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 5 times, mixture is the ethanol of 82% ~ 93%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 60 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.03 ~ 1.10, spraying dry, the inlet temperature 165 ~ 170 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.1 ~ 0.3 times and 0.15 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
10. the preparation method being used for the treatment of the pharmaceutical composition of duck viral hepatitis as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injection, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.11 ~ 8 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 93%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 80% ~ 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 10 DEG C ~ 15 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 ~ 60 minutes at this, the micron particles of acquisition 0.11 ~ 8 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 93%,
3rd step, gets mixed powder 1 ~ 4g that second step obtains, adds sodium chloride 70 ~ 80g, add 1000ml water for injection, stirs and makes it dissolve; Inject water to 10000ml; With 0.2 ~ 0.24 μm of filtering with microporous membrane; Subpackage embedding, every bottle of 250ml, sterilizing.
CN201410504242.4A 2014-09-28 2014-09-28 Pharmaceutical composition for treating duck virus hepatitis and preparation method thereof Pending CN104258252A (en)

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CN104771620A (en) * 2015-03-19 2015-07-15 王洪娟 Drug for postoperative nursing after acute appendicitis surgery and preparation method thereof
CN104982758A (en) * 2015-08-06 2015-10-21 山东新希望六和集团有限公司 Two-stage broiler compound feed and preparing method thereof
CN105410440A (en) * 2015-12-04 2016-03-23 山东新希望六和集团有限公司 DDGS type mixed feed for meat ducks aged in 0-13 days, 14-27 days and 28-39 days and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104771620A (en) * 2015-03-19 2015-07-15 王洪娟 Drug for postoperative nursing after acute appendicitis surgery and preparation method thereof
CN104982758A (en) * 2015-08-06 2015-10-21 山东新希望六和集团有限公司 Two-stage broiler compound feed and preparing method thereof
CN105410440A (en) * 2015-12-04 2016-03-23 山东新希望六和集团有限公司 DDGS type mixed feed for meat ducks aged in 0-13 days, 14-27 days and 28-39 days and preparation method thereof

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