CN103933425A

CN103933425A - Traditional Chinese medicine composition for treating lung cancer and preparation method thereof

Info

Publication number: CN103933425A
Application number: CN201410144562.3A
Authority: CN
Inventors: 胡海波
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-11
Filing date: 2014-04-11
Publication date: 2014-07-23

Abstract

The invention discloses a traditional Chinese medicine composition for treating lung cancer and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw Chinese herbal medicines: dayflower, bjerkandera fumosa, esquirol heterostemma herb, houttuynia cordata, wild buckwheat, cayratia japonica, fructus canarli, calyx seu fructus physalis, tendril-leaved fritillary bulb, radix tinosporae, physalis angulata, oroxylum indicum, scrophularia ningpoensis, Chinese alpine rush, radix rehmanniae, cortex lycii radicis, pyrrosia lingua, polygonum cuspidatum, fructus citri, sheathstipe greenbrier tuber and root, schizaea digitata, bryozoatum, campsis grandiflora, tinospora sinensis merr, sida szechuensis, bamboo shavings, aster, flos farfarae, nux prinsepiae, fructus aristolochiae, sand badger fat, and mallard feathers. The traditional Chinese medicine composition has the effects of nourishing Yin and clearing away heat, and clearing away toxic material and removing stasis, and is mainly used for treating Yin deficiency toxic-heat caused by lung cancer; the treatment based on syndrome differentiation can be carried out as a whole; equilibrium between yin and yang can be regulated for a patient; and the traditional Chinese medicine composition has the advantages of being fast to act, high in efficiency, accurate in treatment and high in safety, and no toxic and side effects, obviously reducing the course of treatment, inhibiting the growth of tumor, raising the tumor inhibition rate along with increase of dose, and interfering tumor cell proliferation, so as to realize the effect of preventing tumor.

Description

A kind of Chinese medicine composition for the treatment of pulmonary carcinoma and preparation method thereof

Technical field

The present invention relates to Chinese medicine preparation technical field, particularly a kind of Chinese medicine composition for the treatment of pulmonary carcinoma and preparation method thereof.

Background technology

Pulmonary carcinoma betides bronchial mucosa epithelium, over nearly 50 years, the sickness rate of pulmonary carcinoma significantly increases, in some industrial big cities of American-European industrially developed country and China, lung cancer morbidity rate ranks first in male's malignant tumor, at women's sickness rate, also increase rapidly, account for the 2nd or the 3rd of women's common cancer.Pulmonary carcinoma becomes a kind of principal disease of life threatening health.

The high risk factor of pulmonary carcinoma has the following aspects: 1. smoking: nineteen twenty-two, Hampeln finds to continue smoking and sucks dust, can stimulate bronchiolar epithelium to bring out cancer.Think that at present smoking is the most basic high risk factor of pulmonary carcinoma, have 3000 kinds of chemical substances of surpassing in Nicotiana tabacum L., multichain compound fragrant hydrocarbon (as: benzopyrene) has very strong carcinogenic activity.Can act on some the special enzyme in tissue (particularly lung tissue), produce the sudden change of cellular elements structure (as DNA), may have the sudden change of K-ras.2. occupation and environmental exposure: the patients with lung cancer estimating at up to 15% has environment and Exposed history, have the following 9 kinds of industrial components of enough proofs to increase the incidence rate of pulmonary carcinoma: the side-product of aluminum products, arsenic, asbestos, bis-chloromethyl ether, chromium compound, coke-fired furnace, mustard gas, nickeliferous impurity, vinyl chloride.The materials such as Long Term Contact beryllium, cadmium, silicon, formalin also can increase the sickness rate of pulmonary carcinoma, and in addition, air pollution, particularly industrial waste gas are all the high risk factors of pulmonary carcinoma.3. radiation: uranium contacts the uranium side-product of noble gas radon gas, decay etc. with fluorite miner, obviously want high, but the personnel of ionizing radiation can not increase the generation of pulmonary carcinoma compared with other people lung cancer incidence.4. pulmonary's chronic infection: as patients such as pulmonary tuberculosis, bronchiectasiss, it is squamous epithelial cancer that bronchiolar epithelium may be changed raw in chronic infection process, whole carcinogenesis, but this class situation is comparatively rare.5. intrinsic factor: family, heredity and congenital factor and Immune Dysfunction, metabolism, endocrine function imbalance etc. may be also the high risk factor of pulmonary carcinoma.

Pulmonary carcinoma claims again primary bronchogenic carcinoma of lung, Chinese medicine is thought, pulmonary carcinoma is because healthy energy interior-deficiency, outer the invading of evil poison cause, turbid cohesion with expectorant, qi depression to blood stasis, pent up in lung, so that lung loses a surname and sends out and the respectful basic pathogenesis of reducing to, take cough, spitting of blood, chest pain, heating, a kind of malignant disease as main clinical manifestation out of breath.Pulmonary carcinoma belongs to the categories such as Chinese medicine " lump in the right hypochondrium ", " painful abdominal mass addiction ", " cough ", " spitting of blood ", " chest pain ".Sick opinion > > as strange in < < Plain Questions says: " sick fullness in the hypochondrium gas superinverse ... name of disease is said lingering dyspnea, and this might as well be in food." < < Ling Shu Miraculous Pivot or Divine Axis pathogen cacosplanchnia shape > > says: " the lung pulse ... micro-urgency is lung cold heat, and idle, hemoptysis, draws back breast." the beautiful machine of < < Plain Questions really hides opinion > > and says: " and osteanabrosis, general pathologic leanness, fullness caused by stagnant QI in the heart, the inconvenience of panting, interior pain is drawn shoulder, and the de-meat of fever of the body breaks rouge." < < difficulty says through the long-pending sick > > of opinion the five internal organs: " the amassing of lung said lump at the right hypochondrium.For a long time endlessly, make us spilling Zhejiang cold and heat, breathe heavily heat, send out lung and stop up." above these are described and the main clinical manifestation of pulmonary carcinoma has similar part.Some side's books of Song dynasty are loaded with treatment cough and see blood, feeling of oppression and pain in the chest, the square medicine of the common syndrome of pulmonary carcinoma such as yellowish complexion body is thin.The lump at the right hypochondrium ball of gold dollar Lee Dong Yuan treatment lump in the right hypochondrium, the card of being controlled is quite like pulmonary carcinoma symptom.The deficient > > of bright Zhang Jingyue < < Jing Yue's complete work says: " chronic cough, celostomia, the sound tachypnea person that can not go out or pant, these lungs lose also, will certainly die." this clinical manifestation with advanced lung cancer is identical, and explicitly point out prognosis mala.< < miscellaneous diseases source and course rhinoceros candle gathers " evil the amassing in the heart; obstructing airway; gas is not declared logical; be expectorant; be food; be blood that lump in the abdomen mass beside the umbilicus painful abdominal mass source and course > > mentions, all must fight with positive, heresy both won, just must not and make it, then form shape and have piece "; illustrated that in lung, the generation of long-pending piece is invaded with positive exogenous pathogen, mechanism of qi is obstructed, and expectorant blood is fought and had pass; for morbidity and the treatment of studying pulmonary carcinoma later age, all has important inspiration meaning.

Up to now, the cause of disease of pulmonary carcinoma is not yet completely clear.But according to patient's onset process and clinical manifestation, the generation of known primary disease and healthy energy prosperity and decline and evil malicious people have invaded comparison close relationship.

The etiology and pathogenesis main manifestations of pulmonary carcinoma is: 1. healthy energy interior-deficiency " healthy energy deposit in, heresy can not be done ", " institute of heresy gathers, and its gas must be empty ".Healthy energy interior-deficiency, internal organs imbalance of YIN and YANG, is the main foundation of suffering from pulmonary carcinoma.As < < Required Readings for Medical Professionals, gather > > said: " then pathogen is crouched it for long-pending one-tenth person, positive QI-insufficiency ".Worn with age, chronic Pulmonary Diseases, lung qi consume forms deficiency; Or damaged by excess of seven emotions, the QI rising in reverse order stagnation of QI, lifting imbalance; Or overwork, lung qi, damage and exhaustion of lung-YIN, exopathogen is taken advantage of a weak point in opponent's defence and people, and exopathogen is detained and is not gone, functional activity of QI being not smooth, the Zhong Zhi pulmonary blood stasis of blood is stagnant, ties and in bulk.2. the Gu Song of tobacco poisoning Nei Qin Qing Dynasty garden is thought: " cigarette is hot chief." long-term smoking, the heat body fluid that burns, cloudy liquid in-fighting, causes lack of lung-YIN, and deficiency of qi and yin accumulates in the gas of tobacco poisoning in addition for a long time, the lung key of stopping over, obstructing airway, and cause phlegm-damp blood stasis congelation, form tumor piece.3. evil poison is invaded lung lung being a delicate viscus, is subject to evil poison invasion and attack, as industrial waste gas, asbestos, Ore dust, coal tar soot and radioactive substance etc., causes the respectful mistake department of falling of lung qi, and lung qi stasis is not declared, and then blood stasis is not all right, and the malicious stasis of blood is tied mutually, forms for a long time lump.4. phlegm-damp gathers lung the spleen being the source of producing phlegm, the lung being the utensil for storing phlegm.The spleen has the function to transport and transform nutrients, the imbalance of insufficiency of the spleen transporting, and essence of water and grain can not biochemical defeated cloth, causes wet consor expectorant, stays in internal organs; Or eating and drinking without temperance, water damp-phlegm is turbid cohesion, expectorant storage lung network, and lung qi a surname falls not normal, phlegm and qi stasis; Or insufficiency of kidney-YANG, lose in evaporating diseases caused by retention of fluid, on diseases caused by retention of fluid, violate in lung, to make humidogene expectorant, and then cause qi and blood stagnation, the poly-heresy of poison is stayed, and in the heart, lump forms gradually in pent-up.

The method for the treatment of pulmonary carcinoma mainly contains non-operative treatment treatment and operative treatment at present, and non-operative treatment also claims expectant treatment, and conventional method has: 1, western medical treatment pulmonary carcinoma: chemotherapy is the primary treatment method of pulmonary carcinoma, and more than 90% pulmonary carcinoma need to be accepted chemotherapeutic treatment.No matter early stage or late period is all more sure chemotherapy to the curative effect of small cell lung cancer, and 1% the early stage small cell lung cancer of even having an appointment is cured by chemotherapy.Chemotherapy is also the Main Means for the treatment of nonsmall-cell lung cancer, and the Tumor response rate of chemotherapeutic treatment nonsmall-cell lung cancer is 40%～50%.Chemotherapy generally can not be cured nonsmall-cell lung cancer, can only extend survival of patients and the quality of making the life better.2, radiotherapy: radiotherapy is best to small cell lung cancer curative effect, and squamous cell carcinoma takes second place, and adenocarcinoma is the poorest.3, surgical treatment for lung cancer is mainly suitable for optionally IIIb phase pulmonary carcinoma of part that early metaphase (I～II phase) pulmonary carcinoma, IIIa phase pulmonary carcinoma and tumor be confined to a pleurobranch chamber.

Yet, western medical treatment pulmonary carcinoma, chemicotherapy side effect is more, can occur the whole body fatigue and weak, lethargy, cold perspiration, drowsiness etc., and chemotherapeutics can damage patient's immune system, causes immunodeficiency or decline.Most of chemotherapeutics all can cause bone marrow depression, show as leukocyte and platelet and decline, very degradation under person's erythrocyte, hematochrome.Part chemotherapeutics can produce cardiac toxicity, infringement myocardial cell, and, even there is heart failure in the symptoms such as having palpitation appears in patient, cardiopalmus, uncomfortable in chest, pareordia is uncomfortable, breathe hard.Can there are the change of T ripple or the change of S-T section etc. in Electrocardioscopy.Although above-mentioned Therapeutic Method can be good at relief of symptoms or pain, therapeutic effect is undesirable, exists treatment time long, weak curative effect, and the defects such as somewhat expensive and side effect, operative treatment is also larger to the vigour damage of body in addition.

Summary of the invention

Technical problem to be solved by this invention is, a kind of replenishing YIN and removing heat that has is provided, the effect of detoxicating and resolving stagnation of pathogens, the Chinese medicine composition of the scorchingly hot card of the mainly curing cancer of lung deficiency of YIN.Chinese medicine composition of the present invention has replenishing YIN and removing heat, the effect of detoxicating and resolving stagnation of pathogens, the scorchingly hot card of the mainly curing cancer of lung deficiency of YIN; Can on whole basis, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adjust patient equilibrium between yin and yang, have rapid-action, efficiency is high, determined curative effect, safe, the advantage that has no side effect, the treatment upper significantly shortening course for the treatment of, can suppress tumor bulk-growth, and tumour inhibiting rate increases progressively with the increase of dosage, disturb the propagation activity of tumor cell, reached antineoplastic action.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of pulmonary carcinoma, wherein, the various raw medicinal materials of described Chinese medicine composition are: Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri, Rhizoma et radix smilacis santis, Schizaea digitata (L.) Sw, Pumex, Flos Campsis, Herba Lycopodii, Herba Sidae Szechuensis, Caulis Bambusae In Taenia, Radix Asteris, Flos Farfarae, Nux Prinsepiae, Fructus Aristolochiae, Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably: Herba Commelinae 15-25 part, sub-clarinet bacterium 10-30 part, Radix seu Herba Heterostemmatis equirolii 15-30 part, Herba Houttuyniae 10-25 part, Rhizoma Fagopyri Dibotryis 15-35 part, Herba Cayatiae Japonicae 15-30 part, Fructus Canarii 10-25 part, Calyx Seu Fructus Physalis 15-35 part, Bulbus Fritillariae Cirrhosae 10-25 part, Radix Tinosporae 10-20 part, Herba Physalis pubescentis 10-25 part, Semen Oroxyli 15-30 part, Radix Scrophulariae 15-35 part, Chinese alpine rush 10-25 part, Radix Rehmanniae 15-30 part, Cortex Lycii 15-35 part, Folium Pyrrosiae 10-25 part, Rhizoma Polygoni Cuspidati 10-30 part, Fructus Citri 15-30 part, Rhizoma et radix smilacis santis 15-35 part, Schizaea digitata (L.) Sw 10-25 part, Pumex 10-25 part, Flos Campsis 10-20 part, Herba Lycopodii 15-35 part, Herba Sidae Szechuensis 15-30 part, Caulis Bambusae In Taenia 15-30 part, Radix Asteris 10-25 part, Flos Farfarae 15-35 part, Nux Prinsepiae 15-20 part, Fructus Aristolochiae 15-20 part, Adeps Arctonyx collaris 10-25 part and Pluma Anas platyrhnchos 10-30 part.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Commelinae 17-22 part, sub-clarinet bacterium 15-25 part, Radix seu Herba Heterostemmatis equirolii 17-25 part, Herba Houttuyniae 15-25 part, Rhizoma Fagopyri Dibotryis 20-35 part, Herba Cayatiae Japonicae 17-25 part, Fructus Canarii 17-25 part, Calyx Seu Fructus Physalis 17-30 part, Bulbus Fritillariae Cirrhosae 10-20 part, Radix Tinosporae 17-20 part, Herba Physalis pubescentis 10-20 part, Semen Oroxyli 18-25 part, Radix Scrophulariae 19-30 part, Chinese alpine rush 18-25 part, Radix Rehmanniae 20-30 part, Cortex Lycii 17-30 part, Folium Pyrrosiae 15-25 part, Rhizoma Polygoni Cuspidati 18-30 part, Fructus Citri 19-30 part, Rhizoma et radix smilacis santis 18-35 part, Schizaea digitata (L.) Sw 19-25 part, Pumex 16-20 part, Flos Campsis 17-20 part, Herba Lycopodii 17-30 part, Herba Sidae Szechuensis 18-25 part, Caulis Bambusae In Taenia 17-25 part, Radix Asteris 16-25 part, Flos Farfarae 20-35 part, Nux Prinsepiae 18-20 part, Fructus Aristolochiae 18-20 part, Adeps Arctonyx collaris 15-25 part and Pluma Anas platyrhnchos 20-30 part.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably again: 18 parts of Herba Commelinaes, 17 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 17 parts of Herba Houttuyniae, 22 parts of Rhizoma Fagopyri Dibotryiss, 17 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 20 parts of Calyx Seu Fructus Physaliss, 15 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 15 parts of Herba Physalis pubescentis, 19 parts of Semen Oroxylis, 20 parts of Radix Scrophulariaes, 20 parts of Chinese alpine rush, 22 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 20 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 18 parts of Flos Campsiss, 19 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 18 parts of Caulis Bambusae In Taenia, 19 parts of Radix Asteriss, 20 parts of Flos Farfaraees, 18 parts of Nux Prinsepiae, 19 parts of Fructus Aristolochiaes, 20 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably again: 20 parts of Herba Commelinaes, 19 parts of sub-clarinet bacterium, 22 parts of Radix seu Herba Heterostemmatis equiroliis, 20 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 20 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 25 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 16 parts of Herba Physalis pubescentis, 20 parts of Semen Oroxylis, 25 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 22 parts of Rhizoma Polygoni Cuspidati, 20 parts of Fructus Citris, 25 parts of Rhizoma et radix smilacis santis, 22 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 20 parts of Flos Campsiss, 25 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 18 parts of Radix Asteriss, 22 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 18 parts of Fructus Aristolochiaes, 25 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably again: 19 parts of Herba Commelinaes, 20 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 19 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 22 parts of Herba Cayatiae Japonicaes, 20 parts of Fructus Canariis, 27 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 20 parts of Radix Tinosporaes, 18 parts of Herba Physalis pubescentis, 22 parts of Semen Oroxylis, 27 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 17 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 30 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 19 parts of Flos Campsiss, 27 parts of Herba Lycopodii, 22 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 22 parts of Radix Asteriss, 26 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 20 parts of Fructus Aristolochiaes, 27 parts of 19 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of pulmonary carcinoma, and wherein, when the dosage form of described Chinese medicine composition is tablet, its preparation method comprises the following steps:

The first step, each raw medicinal material of described Chinese medicine composition is mixed in proportion, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85～95%, reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained are placed in super micron mill and pulverize 1～2 hour, pulverize, and sieve, and obtain 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulates, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes tablet.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of pulmonary carcinoma, and wherein, when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

The first step, Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae are mixed in described ratio, add the water extraction volatile oil with respect to 4～6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stir 60 minutes～90 minutes, 30 ℃～50 ℃ of temperature, obtain volatile oil clathrate compound, standby; The clear paste that while separately aqueous extract being concentrated into 60 ℃, relative density is 1.15～1.17;

Second step, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri and Rhizoma et radix smilacis santis are mixed in described ratio, the alcohol reflux that to add with respect to 5～8 times, mixture amount determining alcohols be 75%～90% 3～5 times, each 2～3 hours, filter respectively, each time filtrate merges, reclaim ethanol, the clear paste that while being concentrated into 60 ℃, relative density is 1.20～1.22, standby;

The 3rd step, by after the raw medicinal material except in the first step and second step, remaining raw medicinal material mixes in described ratio, adds with respect to 8～10 times of water gagings of mixture, boils 6～8 hours, filters the clear paste that while being concentrated into 60 ℃, relative density is 1.28～1.30;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 ℃～70 ℃ reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, then pack in gelatine capsule, obtain capsule.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of pulmonary carcinoma, and wherein, when the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:

The first step, Herba Sidae Szechuensis, Caulis Bambusae In Taenia and Radix Asteris are mixed to the alcohol reflux that to add with respect to 3 times～5 times amount determining alcohols of mixture be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;

Second step, will be except Herba Sidae Szechuensis, Caulis Bambusae In Taenia and Radix Asteris, and remaining raw medicinal material is mixed in proportion, and adds with respect to 3～5 times of water gagings of mixture, boils 2～4 hours, filters, and is concentrated into the mastic that 70 ℃ of relative densities are 1.27～1.29;

The 3rd step, the described mastic that the first step, second step are obtained mix, and 55 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;

The 4th step, will the 3rd add ethanol in the described dried cream powder that obtains of step, and obtain containing alcohol mastic, described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;

The 5th step, will in described dealcoholysis mastic, add cane sugar powder, active carbon, and carry out dilution process, be uniformly mixed to evenly, carry out successively heat treated, filtration treatment, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;

The 6th step, the described semi-finished product that again the 5th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain the oral liquid finished product of described Chinese medicine composition.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine composition of pulmonary carcinoma, and described dosage form is preferably: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, syrup, fumigant, ointment, liniment, tincture, ointment, patch, suppository, plaster, gel or spray.

Chinese medicine composition of the present invention, utilizes the traditional theory of Chinese medical science of China to have replenishing YIN and removing heat, the effect of detoxicating and resolving stagnation of pathogens, the scorchingly hot card of the mainly curing cancer of lung deficiency of YIN; Can on whole basis, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adjust patient equilibrium between yin and yang, have rapid-action, efficiency is high, determined curative effect, safe, the advantage that has no side effect, the treatment upper significantly shortening course for the treatment of, can suppress tumor bulk-growth, and tumour inhibiting rate increases progressively with the increase of dosage, disturb the propagation activity of tumor cell, reached antineoplastic action.

The specific embodiment

The invention provides a kind of Chinese medicine composition for the treatment of pulmonary carcinoma, wherein, described Chinese medicine composition comprises following raw medicinal material: Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri, Rhizoma et radix smilacis santis, Schizaea digitata (L.) Sw, Pumex, Flos Campsis, Herba Lycopodii, Herba Sidae Szechuensis, Caulis Bambusae In Taenia, Radix Asteris, Flos Farfarae, Nux Prinsepiae, Fructus Aristolochiae, Adeps Arctonyx collaris, Pluma Anas platyrhnchos.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Commelinae: sweet, cold, light; Enter the heart, liver,spleen,kidney, all warps of intestine and small intestine.< < Bencao Shiyi > >: " fourth is swollen for main cold and heat subtertian malaria, phlegm retention, and meat disease is not smooth; infantile erysipelas, the mad epilepsy of generating heat, and large abdomen feeling of fullness, body face edema due to disorder of QI; hematodiarrhoea, Serpentis dog stings, the poison such as carbuncle." < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " invigorating QI and blood, treats married woman leucorrhea, red collapsing, tissue regeneration promoting blood, only hematuria, epistaxis blood, stranguria with blood." for fever caused by exogenous pathogens, or febrile disease heating do not move back, or laryngopharynx swelling and pain, and the disease such as carbuncle skin infection.For dysuria, edema, or wet into diseases such as the bladder of making a bet, the puckery pains of dribbling urination.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.The modern multiplex lung abscess of controlling, pneumonia, acute and chronic tracheitis, urinary tract infection etc.Modern pharmacology experiment shows, the effects such as that these product have is antibacterial, antiviral, raising immunity of organisms, diuresis.Clinical report is widely used in treatment pneumonia, spitting of blood, upper respiratory tract infection, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, pulmonary carcinoma, cervical erosion, suppurative arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitisshock, nephrotic syndrome, herpes simplex keratitis, rhinitis, suppurative otitis media, mumps, pimple shape urticaria, chronic pharyngitis, anorectal disease, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.

Rhizoma Fagopyri Dibotryis: cool in nature, acrid in the mouth, hardship.Energy heat-clearing and toxic substances removing, the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore, snake bite and insect sting.Main lung abscess, lung-heat cough with asthma, laryngopharynx swelling and pain, dysentery, rheumatism arthromyodynia, traumatic injury, carbuncle cancer.

Fructus Canarii: puckery, sour, sweet, flat; Enter liver, spleen, lung three warps.< < Compendium of Materia Medica > >: " Fructus Canarii, although this fruit, its color is also blue or green. therefore custom is exhaled Fructus Canarii, eight have yellow skin, and person can't bear, and sick thing is also." function lung heat clearing, sore-throat relieving, promotes the production of body fluid, removing toxic substances.Control laryngopharynx swelling and pain, excessive thirst, cough is spitted blood, bacillary dysentery, epilepsy, separates river intestinal poison and alcoholism.

Calyx Seu Fructus Physalis: bitter, sour, cold; Return lung, spleen channel.Diuresis, heat clearing away, removing toxic substances, sore-throat relieving.For laryngopharynx swelling and pain, cough due to lung-heat, hectic fever due to YIN-deficiency consumptive fever, dysuria, jaundice, edema, pemphigus, hoarseness.Calyx Seu Fructus Physalis fruit water extract has antitumaous effect, and the growth of mice Ehrlich ehrlich ascites carcinoma is had to inhibitory action; The fresh juice of its fruit has inhibitory action to staphylococcus aureus, bacillus pyocyaneus etc.; Hepatitis B virus surface antigen is also had to inhibitory action.

Radix Tinosporae: hardship, cold.Return lung, large intestine channel.The < < property of medicine is examined > >: " removing toxic substances.Throat numbness is anxious, and erosion of mucous membrane of the oral cavity should take.The red furuncle Skin-disease of cellulitis carbuncle carbuncle on the back ， inflammation, snakes and scorpions insect bite, mill is coated with.Control ophthalmalgia, bulge of the ear, cough due to heat, haze miasma, tells nosebleed, all outer diseases." the little knowledge in < < Citrus chachiensis Hort. garden > >: " and the inside and outside stagnation of pathogenic heat of dispelling, all over vicious, the communicable subtropical diseases that disappear, two single throat moth and toothache, shave contains; Mill is coated with furuncle swelling toxin." function heat-clearing and toxic substances removing, sore-throat relieving, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.Except decoct soup for oral administration, also available fresh grass is mashed external application.For traumatic hemorrhage, available Radix Glycyrrhizae levigation, spreading wrapping; With controlling blood stasis, swell and ache, appropriate with fresh grass, mash external application.

Semen Oroxyli: mildly bitter flavor, sweet, cold nature; Return lung, liver, stomach warp.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " broken legendary venomous insect is long-pending, except the poison of tympanitis due to blood stasis, gas legendary venomous insect for Dingchuan, expectorant.Again can tonify deficiency, alleviating distention in middle-JIAO, feed." the < < detailed outline > > that picks up any lost article from the road: " and control motive pain, irritability pain, bottom is damp and hot.Xiang Qiuzi cloud again, all carbuncle poison do not close up, and with this, paste it." sore-throat relieving lung moistening, dispersing the stagnated liver-QI for regulating the stomach, expelling pus and promoting granulation.Cure mainly pharyngalgia sore throat, hoarseness, cough, stomachache due to hyperactive liver-QI attacking the stomach, skin infection is burst and is not held back for a long time, acute eczema.Seed, peel of stem, containing baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel.< < Compendium of Materia Medica > >: " kidney water is injured, Kidney-Yin fall, and lonely positive unrooted, sends out as fire disease, and method should be strengthened water with fire processed, therefore the same merit of Radix Scrophulariae and Radix Rehmanniae.Its scrofula that disappears is also loose fire, and it is that fire is sick that Liu keeps the truth tuberculosis." < < Records of Tradition Chinese and Western Medicine in Combination > >: " many liquid cool in nature, was the medicine of the kidney invigorating warp clearly originally for Radix Scrophulariae, sweet and slightly bitter taste.Can enter again lung with the bright heat of lung heat clearing man, removing toxic substances quench, is suitable for pneumonopathy tuberculosis most, cough due to lung-heat." < < Japan hanako materia medica > >: " and control wind syndrome of head pyretic toxicity urticaria, tonify deficiency strain, the heart is frightened irritated, and bad weary hectic fever due to YIN-deficiency passes corpse pathogen, only forgetful, detumescence poison." there is clearing away heat and cooling blood, eliminating fire and detoxication, the effect of YIN nourishing, cures mainly warm febrile disease and nutrient blood, fever of the body, excessive thirst, crimson tongue, the cards such as constipation, order puckery dim-sighted, throat larynx swells and ache, scrofula sucutaneous nodule, skin sore are not hindered in awake, Tianjin to send out speckle, hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency.

The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.< < Sheng Nong's herbal classic > >: " sweet in the mouth, cold.Cure mainly folding and fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat.Make soup and gather except cold and heat, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in treating the diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.

Cortex Lycii: cold in nature, sweet in the mouth; Enter lung, liver, kidney channel.< < does not record > >: " main air is wet, lower breast side of body gas, exopathogenic heat headache, mends internal injury great Lao suctions of hissing, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, summer-heat resists cold." < < book on Chinese herbal medicine is stated > >: " cures mainly deficient fever, and alternate attacks of chills and fever is allly shown in blood disorder, epistaxis, cough blood, cough, breathe heavily diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, fidgets due to deficiency, throbs with fear, forgetful; urinary obstruction, reddish and whitish turbid urine." removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition heating, quenches one's thirst, and pulmonary cough is breathed heavily, spits blood, epistaxis, hematuria.

Folium Pyrrosiae: cold nature, sweet in the mouth, hardship.Feeble QI, the micro-puckery hardship of taste.< < Sheng Nong's herbal classic > >: " Folium Pyrrosiae, bitter in the mouth is flat, main consumptive fever pathogen, five difficulty in urinations are obstructed, and diuresis water is logical, and a stone fasten hide or leather on (sound sugarcane), on the stone of raw mountain valley." < < Bencao Congxin > >: " and the cloudy place of calculogenesis, pliable and tough as skin.Person in raw GUWA, name Herba Lepisori Thunbergiani, controls pouring also good." the high former > > of < < book on Chinese herbal medicine: " Folium Pyrrosiae cures mainly consumptive fever pathogen person, and consumptive fever is at bone, and pathogen is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid difficulty in urinations, dysuria is also.Folium Pyrrosiae helps the vital essence of lung kidney, and upper downcrossings, moisten on crystal, and the outer key of upper orifices is all logical, changes, capable the and normal urination of water channel under lung qi." function relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.The cytophagous activate the phagocytic capacity of Folium Pyrrosiae energy enhancing body, and have some antitumaous effect.

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, the effect of preventing phlegm from forming and stopping coughing, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.Polygoni cuspidati,radix is done cold drink, puts cooling down name in cold water, and " cold drink ", cooling and heatstroke-eliminating is for tea.Its juice can dye rice flour, has a distinctive flavour.Therefore edible, with its sour in the mouth, also claim " sour soup bar ".Rhizoma Polygoni Cuspidati contains knotweed glycoside, organic acid, glycoside, polysaccharide etc.Rhizoma Polygoni Cuspidati has and suppresses and killing action staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, micrococcus catarrhalis, newcastle, Bacillus proteus, bacillus pyocyaneus etc.

Fructus Citri: acrid in the mouth, sweet is nontoxic.< < explaining abstruseness of the canon of materia medica > >: " gas of the reason part of the body cavity above the diaphragm housing the heart and lungs, preventing or arresting vomiting is contrary, feed, spleen invigorating." < < book on Chinese herbal medicine new > > again: " diuretic that stimulates the menstrual flow, controls waist beriberi for suppressing the hyperactive liver Shu Yu, reason lung qi." function depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in.Cure mainly the therapeutic method to keep the adverse QI flowing downwards, except mind expectorant water.With the abdominal distention of controlling stagnation of QI in spleen and stomach, bitter dry the falling of these product let out with preventing phlegm from forming and stopping coughing, and pungent row enters lung and the chest stuffiness relieving of regulating the flow of vital energy.With controlling abundant expectoration, cough, uncomfortable in chest etc.The contained hesperidin of these product to Cavia porcellus for want of vitamin C and the eyes bulbar conjunctiva blood vessel inner cell cohesion that causes and capillary resistance reduce and be improved effect, can reduce the cohesion of horse blood cell.Hesperidin has prevention cold injury and suppresses the aldehyde reductase effect of rat lens.Obacunone has the effect that strengthens isolated rabbit intestinal tension force and amplitude.

Bulbus Fritillariae Cirrhosae: the large hardship of taste, cold in nature; Enter lung, the heart, stomach, Liver Channel.The positive > > of < < book on Chinese herbal medicine: " great order lung abscess lung withers, and cough with asthma is spitted blood, and mental disorder, falls most in epistaxis; kind relieving stagnation, the pain that relieves the pain, relieving distension is full, clearing away liver-fire; improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, the hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, and acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times." < < Shandong Chinese herbal medicine handbook > >: " removing heat from the lung and dissipating phlegm, antacid, removing toxic substances." < < Sheng Nong's herbal classic meets former > >: " Bulbus Fritillariae Uninbracteatae, river person's sweet in the mouth is best: western thin taking second place of person's taste, the micro-hardship of Xiangshan person is taken second place again, and a kind of large and bitter person only can detoxify.And go the heart to use.All lung meridian medicines all ought remove the heart, and not only Bulbus Fritillariae Uninbracteatae also." removing heat-phlegm, powder detoxifcation.With controlling cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.Antitussive peimine and peiminine have antitussive effect, spasmolytic Bulbus Fritillariae Uninbracteatae alkaloid has atropine-like effect, low concentration can make tracheal smooth muscle lax, and high concentration can make tracheal smooth muscle slight shrinkage, and central nervous system's effect peimine and peiminine are had to calmness and analgesic activity.

Pumex: be generally white, light gray, be once in a while light red.The vesicular structure with standard, likeness in form moth nest, has tubular structure sometimes.Surface dimness or tool silky luster.Property is crisp.Proportion is little, in water, can float.Rock for volcanic eruption goes out, mainly consists of the nature of glass, even containing a small amount of crystalline mineral.Salty, cold; Enter lung, kidney, liver, large intestine channel.The positive > > of < < book on Chinese herbal medicine: " help digestion, the heat-phlegm that disappears, antipyretic thirsty pyretic stranguria, stops phlegmatic cough dyspnea with rapid respiration, softening the hard mass disease, diuretic is wet." < < Japan hanako materia medica > >: " quench the thirst, control pouring, kill wild beast poison." lung heat clearing fire, change old expectorant, relieving stranguria by diuresis, hard masses softening and resolving.Cure mainly phlegm-heat obstructing in the lung, the thick difficulty of cough with asthma expectorant is coughed up, the puckery pain of dribbling urination, goiter scrofula.

Flos Campsis: sweet, sour, cold; Return liver, pericardium channel.< < Compendium of Materia Medica > >: " stem and leaf band is bitter for Ling Leihua and root, sweet acid and trembling with fear, and promoting the circulation of blood divides, and the fire second of the three ten-day periods of the hot season of dehematizing, therefore the card of the main product breast all diseases of metrorrhagia and blood hot air wind producing also." < < herbal classic meets former > >: " and Ling Xuehua, metopodynia blood closes, pricking caused by the stagnation of QI and blood, strict wind malignant boil multiplex it, all get the merit of its dispelling malignant blood also." < < Sheng Nong's herbal classic > >: " and the remaining disease of housewife people's galactopoiesis, metrorrhagia, lump in the abdomen, blood closes, cold and heat weakness and emaciation." promoting the circulation of blood blood stasis removing, cooling blood, expelling wind.For Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth; Enter lung, stomach warp.< < book on Chinese herbal medicine is new > > again: " pathogenic fire purging relieving restlessness, lung moistening dissipating depression of QI, the removing heat from blood that reduces phlegm, emesis blood, Removing Blood Stasis, eliminating carbuncle flaccidity toxic swelling." < < detailed outline > >: " the cold recurrence caused by overexertion that cures the wound, little Re Epilepsy, married woman's fetal movement." the positive > > of < < book on Chinese herbal medicine: " and control consumptive lung disease saliva expectorant, hematuria, married woman's heat in blood collapses pouring, fetal movement, and children's wind-heat epilepsy, mental disorder is breathed with cough, and little hydro-thermal is puckery." function removing heat-phlegm, relieve restlessness and prevent vomiting.For phlegm-heat cough, gallbladder fire, hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.Being slightly cold property of Caulis Bambusae In Taenia sweet in the mouth profit.Caulis Bambusae In Taenia powder all has stronger antibacterial action to Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi etc. on plate.

Radix Asteris: warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing.Cure mainly cough, deficiency of the lung chronic cough, consumptive lung disease lung abscess, coughs vomiting bloody pus, dysuria.For abundant expectoration, breath with cough, new chronic cough is coughed, chronic cough hemoptysis.Be used for the treatment of chronic cough asthma.From Radix Asteris, isolated epifriedelanol has certain antitumaous effect to ehrlich carcinoma.

Flos Farfarae: acrid in the mouth, warm in nature; Return lung meridian.< < Japan hanako materia medica > >: " profit cardiopulmonary, beneficial the five internal organs, relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, pulmonary fistula is spitted blood, and the palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy." < < book on Chinese herbal medicine takes advantage of refined half brave > >: " and Flos Farfarae is with controlling cough with dyspnea, kind breathing heavily, sore throat, and because kidney is bitter dry and cold physique drink is cold, being attacked by pathogenic dampness in autumn person is begun suitable.Or burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears to sparkle and injures." preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.Flower is containing sterols, globulariacitrin, hyperin, triterpenoid saponin, tannin, wax, volatile oil and taraxanthins such as faradiols.

Fructus Aristolochiae: bitter in the mouth, cold nature, returns lung, large intestine channel, has lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, the disappear effect of hemorrhoid of bowel relieving, for dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, the cards such as swelling and pain of hemorrhoid.Fructus Aristolochiae draws to ammonium hydroxide spraying the method model of coughing obvious antitussive effect, and action intensity and codeine phosphate are suitable.Fructus Aristolochiae has gentleness and lasting hypotensive effect is applicable to more early stage hypertension preparation and usage various places be not quite similar, and curative effect is also slightly variant.

Sub-clarinet bacterium: nature and flavor: micro-puckery; Flat.Cure mainly: anticancer.Main uterus carcinoma.

Herba Cayatiae Japonicae: nature and flavor: picric acid, cold.1. < < Tang materia medica > >: " sour in the mouth is bitter, cold, nontoxic." 2. < < Lv Cliff rock book on Chinese herbal medicine > >: " is sweet, cold, nontoxic." 3. < < Kweiyang medicinal herbs > among the people >: " toil, flat, nontoxic." returning through the herbal > > in east: < < Fujian: " enters the heart, liver, stomach three warps." cure mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Control carbuncle, furuncle, mumps, erysipelas, rheumatalgia, jaundice, dysentery, hematuria, nebulousurine.For laryngopharynx swelling and pain, furuncle and phyma, carbuncle, furuncle, dysentery, hematuria, nebulousurine, traumatic injury, venom.1. TAO Hong-Jing: " smash that to apply skin ulcer swollen, snakeworm stings place." 2. < < Tang materia medica > >: " main air is scorchingly hot swollen, and trip is red, and snakebite is smash and applied and drink juice." 3. < < Lv Cliff rock book on Chinese herbal medicine > >: " controlled carbuncle carbuncle on the back, mashed net for catching birds or fish affected part." 4. < < detailed outline > >: " removing pathogenic heat from blood and toxic substance from the body, diuresis; Root is beaten wine clothes, and furuncle and phyma disappears." 5. < < vegetation just square > >: " heat-clearing and toxic substances removing, is coated with sore, the tuberculosis that disappears, nine fictitious gas infectionss.Tonification is deficient." 6. < < classification medical herbs > >: " removes the wind expectorant that falls apart.Control five kinds of jaundice, sow wind; Be coated with sore." 7. < < plants in Jiangsu medicine will > >: " hot water bubble, smoked lower limb can pain relieving.The paralysis of " 8. < < Kweiyang medicinal herbs > among the people >: " dispelling the wind and dampness pathogens." 9. < < Hunan medicine will > >: " controls migraine, hemorrhoid." 10. < < Fujian east herbal > >: " controls diarrhea of heat type, dysentery."

Herba Physalis pubescentis: nature and flavor: 1. < < Jiangxi traditional herbal medicine proved recipe > >: " cold in nature, bitter in the mouth is nontoxic." 2. Chinese herbal medicine > > is commonly used in < < Shanghai: " acid, flat." cure mainly: heat clearing away, diuresis, removing toxic substances.Cure cold, cough due to lung-heat, laryngopharynx swelling and pain, swelling of the gum, jaundice due to damp-heat, dysentery, edema, pyretic stranguria, pemphigus, furuncle.1. < < Jiangxi traditional herbal medicine > >: " control pemphigus, infection with swollen head, furuncle of finger, gingival swelling and pain, jaundice due to damp-heat, red swelling and pain of throat, cough due to lung-heat, pyretic stranguria." 2. Chinese herbal medicine > > is commonly used in < < Shanghai: " heat-clearing and toxic substances removing, diuresis hemostasis, dispersing swelling and dissipating binds.Control laryngopharynx swelling and pain.Lung abscess, parotitis; Dysuria, hematuria.Gingival swelling and pain, pemphigus." Chinese alpine rush: nature and flavor: sweet; Light; Cool.Cure mainly: heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main flu; Infantile pneumonia; Pulmonary tuberculosis spitting of blood; Epistaxis; Hematuria; Blockage of menstruation; Pyretic stranguria; Mastitis; Urticaria; Traumatic hemorrhage.

Schizaea digitata (L.) Sw: nature and flavor: micro-hardship; Cool.Gui Jing: lung meridian.Cure mainly: heat-clearing and toxic substances removing.Main cold, fever; Tonsillitis; Laryngopharynx swelling and pain.

Herba Sidae Szechuensis: nature and flavor: 1. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " cold in nature, bitter in the mouth." 2. < < Yunnan Chinese herbal medicine > >: " hardship, flat." cure mainly: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Control acute mastitis, acute tonsillitis, furuncle, toxic swelling, enteritis, bacillary dysentery, women's amenorrhea, traumatic injury.1. < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " control married woman's galactostasis, acute mastitis, breast knot, redness, all pyogenic infections from tumour or sore disappear; Control children's's hematuria, stranguria with blood, the skin pruritus of dispelling, pathogenic wind expelling is antipyretic.Stalk leaf smalls, it is defeated and dispersed that vinegar dresses skin sore." 2. < < Yunnan Chinese herbal medicine > >: " blood circulation promoting and blood stasis dispelling, draws out pus by applying a plaster to the affected part, synthetism, lactogenesis.Control amenorrhea, furuncle, gunshot wound, fracture." 3. < < Yunnan Chinese herbal medicine selects > >: " antiinflammatory, removing toxic substances and promoting tissue regeneration.Control acute mastitis, acute tonsillitis, enteritis, bacillary dysentery."

Nux Prinsepiae: nature and flavor: sweet, cold.1. < < does not record > >: " be slightly cold, nontoxic." 2. > > is wanted in the bun of < < medical center: " is sweet salty, cold." return through: enter liver, heart channel.1. < < Thunder God is concocted property of medicine solution > >: " enter the heart, liver, spleen three warps." 2. the beautiful Chinese catalpa medicine of < < solution > >: " start with lunar lung, liver channel of foot-Jueyin." cure mainly: dispel the wind, heat radiation, nourishing the liver, improving eyesight.Control conjunctival congestion and swelling pain, dim photophobia, the rotten many tear of the corner of the eyes, epistaxis.1. < < herbal classic > >: " conjunctival congestion with ophthalmalgia is hindered lacrimation for main trusted subordinate's pathogens agglomerating gas, improving eyesight." 2. < < WU Pu Bencao > >: " strong will of invigorating middle warmer, improve visual and auditory acuity." 3. < < does not record > >: " order corner of the eyes Lan ， Weng nose that swells, ties fullness and oppression sensation in the epigastrium due to accumulation of phlegm gas under the broken heart." 4. < < property of medicine opinion > >: " controls epistaxis." 5. < < Bencao Shiyi > >: " raw foot of controlling is slept, the ripe sleeplessness of controlling." 6. < < book on Chinese herbal medicine covers bamboo fish trap > >: " specially controls ophthalmology, the rotten string of upper lower eyelid swelling due to wind that disappears, and except left and right corner of the eyes thermal boundary bulbar conjunctiva polyp, annealing arresting lacrimation, beneficial aquatic light."

Radix seu Herba Heterostemmatis equirolii: nature and flavor: pungent, flat.Cure mainly: dehumidifying, removing toxic substances.

Herba Lycopodii: sweet in the mouth, hardship, pungent, effect is controlled wind heat, plague fever while removing, effect is slow, can be in harmonious proportion and occlusion disorder, controls ageing diseases, rheumatism." say in the pond > > of < < manna:: " strangle wise sweet in the mouth, hardship, puckery, pungent, change sweet in the mouth, acid, property profit, cool, warm, controls dragon, red bar complication, Baconic's disease, rheumatism, wind heat disease." the ring > > of < < manna says: " strangle wise sweet in the mouth, hardship, change sweet in the mouth, acid, skin is sweet.Nature and flavor: mildly bitter flavor; Cool in nature.Gui Jing: Liver Channel.Cure mainly: wind-expelling pain-stopping; Relaxing muscles and tendons and activating QI and blood in the collateral.Main air pain of dampness syndrome; Lumbar muscle strain; Traumatic injury.

Adeps Arctonyx collaris: claim again: Included-in-the-Appendices fat, Included-in-the-Appendices pig cream, sand badger oil, Included-in-the-Appendices is oily, aardvark is oily.Nature and flavor: sweet in the mouth; Property is put down.Gui Jing: lung meridian.Cure mainly: nourishing the lung to arrest cough; Removing dampness and detoxicating.Main consumptive lung disease; Cough with dyspnea; Tinea alba; Stubborn dermatitis; Hemorrhoid; Ecthyma.

Pluma Anas platyrhnchos: nature and flavor: salty in the mouth; Property is put down.Gui Jing: lung meridian.Cure mainly: removing toxic substances sore.Main ulcer and burn due to hot liquid or fire.

Chinese alpine rush: nature and flavor: sweet; Light; Cool.Cure mainly: heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main flu; Infantile pneumonia; Pulmonary tuberculosis spitting of blood; Epistaxis; Hematuria; Blockage of menstruation; Pyretic stranguria; Mastitis; Urticaria; Traumatic hemorrhage.

Rhizoma et radix smilacis santis: nature and flavor: 1. < < Gansu Chinese herbal medicine handbook > >: " pungent salty, temperature." 2. < < Henan economic plants will > >: " bitter in the mouth, property is flat, nontoxic." cure mainly: expelling wind and removing dampness, activating blood cirulation to regulate QI flow, pain relieving.Dispelling the wind and dampness pathogens pain, traumatic injury, traumatic hemorrhage, fishbone bone stuck in the throat.1. < < Gansu Chinese herbal medicine handbook > >: " expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Dispelling the wind and dampness pathogens waist knee joint limbs pain is not healed for a long time, fishbone bone stuck in the throat." 2. < < Henan economic plants will > >: " promoting blood circulation and stopping pain.Control injured, wound." 3. < < China's economic flora > >: " pleasant analgesia."

Fructus Canarii: claim again Fructus Canarii albi, Bai Lan, Gan Lan.Nature and flavor: property is flat, sweet in the mouth, acid.Cure mainly: heat clearing away, sore-throat relieving, promotes the production of body fluid, removing toxic substances.Poisoning for laryngopharynx swelling and pain, cough, excessive thirst, fish Eriocheir sinensis.

Chinese alpine rush: another name: entangle grass, mountain grass, Herba Poae Sphondylodis, sheep singly, SHANMAO is careless.Nature and flavor: sweet; Light; Cool.Cure mainly: heat-clearing and toxic substances removing; Cool the blood dissipate blood stasis.Main flu; Infantile pneumonia; Pulmonary tuberculosis spitting of blood; Epistaxis; Hematuria; Blockage of menstruation; Pyretic stranguria; Mastitis; Urticaria; Traumatic hemorrhage.

Wherein, the various raw medicinal materials of described Chinese medicine composition are: Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri, Rhizoma et radix smilacis santis, Schizaea digitata (L.) Sw, Pumex, Flos Campsis, Herba Lycopodii, Herba Sidae Szechuensis, Caulis Bambusae In Taenia, Radix Asteris, Flos Farfarae, Nux Prinsepiae, Fructus Aristolochiae, Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material of compositions can be preferably again: 18 parts of Herba Commelinaes, 17 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 17 parts of Herba Houttuyniae, 22 parts of Rhizoma Fagopyri Dibotryiss, 17 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 20 parts of Calyx Seu Fructus Physaliss, 15 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 15 parts of Herba Physalis pubescentis, 19 parts of Semen Oroxylis, 20 parts of Radix Scrophulariaes, 20 parts of Chinese alpine rush, 22 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 20 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 18 parts of Flos Campsiss, 19 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 18 parts of Caulis Bambusae In Taenia, 19 parts of Radix Asteriss, 20 parts of Flos Farfaraees, 18 parts of Nux Prinsepiae, 19 parts of Fructus Aristolochiaes, 20 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material of compositions can be preferably again: 20 parts of Herba Commelinaes, 19 parts of sub-clarinet bacterium, 22 parts of Radix seu Herba Heterostemmatis equiroliis, 20 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 20 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 25 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 16 parts of Herba Physalis pubescentis, 20 parts of Semen Oroxylis, 25 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 22 parts of Rhizoma Polygoni Cuspidati, 20 parts of Fructus Citris, 25 parts of Rhizoma et radix smilacis santis, 22 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 20 parts of Flos Campsiss, 25 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 18 parts of Radix Asteriss, 22 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 18 parts of Fructus Aristolochiaes, 25 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material of compositions can be preferably again: 19 parts of Herba Commelinaes, 20 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 19 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 22 parts of Herba Cayatiae Japonicaes, 20 parts of Fructus Canariis, 27 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 20 parts of Radix Tinosporaes, 18 parts of Herba Physalis pubescentis, 22 parts of Semen Oroxylis, 27 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 17 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 30 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 19 parts of Flos Campsiss, 27 parts of Herba Lycopodii, 22 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 22 parts of Radix Asteriss, 26 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 20 parts of Fructus Aristolochiaes, 27 parts of 19 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet of the present invention

The manufacturing process of oral medicine tablet of the present invention is: get Herba Commelinae 1800g, sub-clarinet bacterium 1700g, Radix seu Herba Heterostemmatis equirolii 1800g, Herba Houttuyniae 1700g, Rhizoma Fagopyri Dibotryis 2200g, Herba Cayatiae Japonicae 1700g, Fructus Canarii 1800g, Calyx Seu Fructus Physalis 2000g, Bulbus Fritillariae Cirrhosae 1500g, Radix Tinosporae 1800g, Herba Physalis pubescentis 1500g, Semen Oroxyli 1900g, Radix Scrophulariae 2000g, Chinese alpine rush 2000g, Radix Rehmanniae 2200g, Cortex Lycii 2000g, Folium Pyrrosiae 1800g, Rhizoma Polygoni Cuspidati 2000g, Fructus Citri 2200g, Rhizoma et radix smilacis santis 2000g, Schizaea digitata (L.) Sw 2000g, Pumex 1800g, Flos Campsis 1800g, Herba Lycopodii 1900g, Herba Sidae Szechuensis 2000g, Caulis Bambusae In Taenia 1800g, Radix Asteris 1900g, Flos Farfarae 2000g, Nux Prinsepiae 1800g, Fructus Aristolochiae 1900g, Adeps Arctonyx collaris 1700g and Pluma Anas platyrhnchos 2000g,

The first step, each raw medicinal material of described Chinese medicine composition is mixed in proportion, adds the ethanol that the determining alcohol with respect to 3 times of mixture qualities is 85%, reflux 1 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1.5 times of described medicinal residues quality is 85% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained are placed in super micron mill and pulverize 1 hour, pulverize, and sieve, and obtain 370 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.2 times of its quality, 0.05 times of lactose, the starch of 0.2 times, sieve, and mix homogeneously, granulate, dry, add with respect to 0.009 times of magnesium stearate of micropowders quality, granulate, tabletting, makes tablet.

Embodiment 2 capsule of the present invention

The manufacturing process of oral medicine capsule of the present invention is: get Herba Commelinae 2000g, sub-clarinet bacterium 1900g, Radix seu Herba Heterostemmatis equirolii 2200g, Herba Houttuyniae 2000g, Rhizoma Fagopyri Dibotryis 2500g, Herba Cayatiae Japonicae 2000g, Fructus Canarii 1800g, Calyx Seu Fructus Physalis 2500g, Bulbus Fritillariae Cirrhosae 1700g, Radix Tinosporae 1800g, Herba Physalis pubescentis 1600g, Semen Oroxyli 2000g, Radix Scrophulariae 2500g, Chinese alpine rush 2200g, Radix Rehmanniae 2500g, Cortex Lycii 2000g, Folium Pyrrosiae 1800g, Rhizoma Polygoni Cuspidati 2200g, Fructus Citri 2000g, Rhizoma et radix smilacis santis 2500g, Schizaea digitata (L.) Sw 2200g, Pumex 1800g, Flos Campsis 2000g, Herba Lycopodii 2500g, Herba Sidae Szechuensis 2000g, Caulis Bambusae In Taenia 2000g, Radix Asteris 1800g, Flos Farfarae 2200g, Nux Prinsepiae 1900g, Fructus Aristolochiae 1800g, Adeps Arctonyx collaris 1700g and Pluma Anas platyrhnchos 2500g,

The first step, Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae are mixed in described ratio, add the water extraction volatile oil with respect to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtaining, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 5, stir 90 minutes, temperature 45 C, obtains volatile oil clathrate compound, standby; The clear paste that while separately aqueous extract being concentrated into 60 ℃, relative density is 1.15;

Second step, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri and Rhizoma et radix smilacis santis are mixed in described ratio, the alcohol reflux that to add with respect to 7 times, mixture amount determining alcohols be 80% 4 times, each 2.5 hours, filter respectively, each time filtrate merges, reclaim ethanol, the clear paste that while being concentrated into 60 ℃, relative density is 1.20, standby;

The 3rd step, by after the raw medicinal material except in the first step and second step, remaining raw medicinal material mixes in described ratio, adds with respect to 10 times of water gagings of mixture, boils 8 hours, filters the clear paste that while being concentrated into 60 ℃, relative density is 1.29;

The 4th step, mixes the clear paste of the first step, second step, the 3rd step, and 65 ℃ of reduced vacuum are dry, and powder gets dry extract;

The 5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 6 weight portion carboxymethyl starch sodium, 20 weight portion starch mix homogeneously, adding 1180 weight portion determining alcohols is 85% alcohol granulation, dry, granulate, add subsequently the mixture with respect to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 4 weight portion magnesium stearate, then pack in gelatine capsule, obtain capsule.

Embodiment 3 oral liquid of the present invention

The manufacturing process of oral medicine oral liquid of the present invention is: get Herba Commelinae 1900g, sub-clarinet bacterium 2000g, Radix seu Herba Heterostemmatis equirolii 1800g, Herba Houttuyniae 1900g, Rhizoma Fagopyri Dibotryis 2500g, Herba Cayatiae Japonicae 2200g, Fructus Canarii 2000g, Calyx Seu Fructus Physalis 2700g, Bulbus Fritillariae Cirrhosae 1700g, Radix Tinosporae 2000g, Herba Physalis pubescentis 1800g, Semen Oroxyli 2200g, Radix Scrophulariae 2700g, Chinese alpine rush 2200g, Radix Rehmanniae 2500g, Cortex Lycii 2000g, Folium Pyrrosiae 1700g, Rhizoma Polygoni Cuspidati 2000g, Fructus Citri 2200g, Rhizoma et radix smilacis santis 3000g, Schizaea digitata (L.) Sw 2000g, Pumex 1800g, Flos Campsis 1900g, Herba Lycopodii 2700g, Herba Sidae Szechuensis 2200g, Caulis Bambusae In Taenia 2000g, Radix Asteris 2200g, Flos Farfarae 2600g, Nux Prinsepiae 1900g, Fructus Aristolochiae 2000g, Adeps Arctonyx collaris 1900g and Pluma Anas platyrhnchos 2700g,

When the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:

Long term toxicity test:

Respectively by the tablet of the embodiment of the present invention 1 preparation, the capsule of embodiment 2 preparations, the Oral Liquid On Mice of embodiment 3 preparations is by 10.78, 20.35 and 16 weeks (1.0ml/100g body weight of 33.48g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese drug anesthesia medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Acute toxicity testing:

80 of application NIH mices, SPF level, male and female half and half, body weight 18～22g, carries out acute toxicity test.Mice is divided into four groups at random, and 20 every group, matched group and administration group (embodiment group 1, embodiment group 2, embodiment group 3), test front fasting 12 hours; Just the capsule of the tablet of embodiments of the invention group 1 preparation, 2 preparations of embodiment group and the oral liquid of embodiment group 3 preparations are dissolved in water respectively, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>32.9 of the present invention crude drug/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.4g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 20g) oral administration gavage Chinese medicine of the present invention is quantity 901 times.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

Tumor-inhibiting action experiment:

Subjects: 100 of ICR mices, body weight 19-24g, male.

Test inoculation content: S180 solid tumor.

Get ICR mice, in the subcutaneous conventional inoculation S180 cancerous cell suspension 0.2ml (approximately 5 * 106 cell/m1) of right axil, be divided at random 5 groups next day.Treatment group is divided into three groups, is respectively high dose group, middle dosage group and low dose group, adopts the tablet of the embodiment of the present invention 1, and after pulverizing, distilled water dissolves, and every day is gastric infusion 1.2ml, 0.8m1 and 0.4m1 respectively, continuous 10 days; Matched group is divided into two groups, is respectively normal saline group and CTX group, and normal saline group stomach every day is raised 0.4m1 normal saline, continuous 10 days; CTX group administration cyclophosphamide, administration every day 0.2g, gastric infusion after distilled water dissolves, continuous 10 days; 5 groups are after drug withdrawal and put to death animal next day, stripping tumor is weighed, calculate tumour inhibiting rate, tumour inhibiting rate formula is: the average tumor of tumour inhibiting rate (%)=(the average tumor weight of the average tumor weight-medication of normal saline matched group group)/normal saline matched group heavy * 100%, result shows, to S180, growth has inhibitory action to medicine of the present invention, and its tumour inhibiting rate increases and increases progressively with dosage, has compared significant difference P<0.05 with matched group.To the inhibitory action of S180 and tumor killing effect in Table 1.

Table 1: to the inhibitory action of S180 and tumor killing effect

Group	Average tumor heavy (g)	Mice average weight changes (g)	Tumour inhibiting rate (%)
				High dose group	1.41±0.38	﹢3.95	56.88
Middle dosage group	1.56±0.62	﹢4.42	52.29
				Low dose group	1.67±0.26	﹢4.84	48.93
CTX group	1.34±0.42	﹣1.68	59.02
				Normal saline group	3.27±0.89	﹢5.03	0

Known by table 1: adopt the treatment group of Chinese medicine composition of the present invention, with the comparison of normal saline group, can suppress tumor bulk-growth, and tumour inhibiting rate to increase progressively with the increase of dosage, have significant difference P<0.05, (n=10, X ± SD); Adopt the treatment group of Chinese medicine composition of the present invention, with CTX group relatively, the body weight of the mice for the treatment of group has increase, and the Mouse Weight of CTX group alleviates, both significant difference P<0.05 that compared, (n=10, X ± SD).

By fluid cell instrument, measure in addition, result shows, Chinese medicine composition of the present invention has stoped tumor cell by S → G2 process, also affected the carrying out of G1 → S simultaneously, S and the cell of G1 phase are obviously increased, the cell of G2 and M phase is relatively low, has disturbed the propagation activity of tumor cell, reaches antineoplastic action.

Clinical treatment:

Case selection: fetch patients with lung cancer 300 examples that come from the court's oncology, male 199 examples, female's 101 examples; 36～68 years old age, medical history 6 months～8 years; 300 routine patients with lung cancer are divided into two groups at random, are respectively treatment by Chinese herbs group and Chinese patent medicine matched group, wherein, and treatment by Chinese herbs group 174 examples, male 112 examples, female's 62 examples; Chinese patent medicine matched group 126 examples, male 87 examples, female's 39 examples.

The clinical symptoms main manifestations of 300 routine patients with lung cancer is the following aspects:

1, cough: be early stage modal symptom, be characterized in that paroxysmal irritable cough is main, without expectorant or a small amount of white expectorant of foam.Tumor increases and causes bronchial stenosis, and cough increases the weight of, and mostly is persistence, is high-pitched tone metallic sound.When bronchial stenosis far-end has pulmonary's secondary infection, amount of expectoration increases, and is mucopurulent sputum.

2, chest pain: tumor is involved pleura or mediastinum, can produce erratic chest dull pain or dull pain, and tumor corrodes thoracic wall rib or compressing intercostal nerves, and chest pain is sharply violent, and has fixed point or local tenderness, and increases the weight of with breathing, cough, changing position.

3, hemoptysis: be also pulmonary carcinoma common one of onset symptoms, interstitial laser photocoagulation rich blood vessel, a small amount of sputum mixed with blood repeatedly of normal persistence or discontinuity, wayward, during cancerous protuberance corrosion trunk, can cause large mouthful of spitting of blood, color is fresh.

4, out of breath: bronchial stenosis, obstruction causes out of breath, is more common in central type carcinoma of lung.Enlarged lymph node is oppressed large bronchus or protuberantia, or bronchioles one alveolar cell carcinoma is when extensively send out, and carrying out property out of breath increases the weight of, and with cyanosis.A large amount of hydrothorax, all can there is serious phenomenon out of breath in pericardial effusion etc.

5, heating: pulmonary carcinoma mid-term after antibiotic therapy, can alleviate because obstructive pneumonia causes heating by symptom, and stage, because cancerous tissue degeneration necrosis causes cancer fever, generates heat often persistent, and antibiotic therapy is invalid.Most patients companion night sweat, xerostomia, vexed, the symptoms such as feverish sensation in the palms and soles.

6, become thin: patients with terminal, due to infection, the loss of appetite due to pain etc., the consumption that tumor toxin causes etc. all can cause becomes thin, complexion grey from, spiritlessness and weakness etc. develop into cachexia gradually.

Treatment by Chinese herbs group: 174 routine patients are divided into three groups at random, every group of 58 routine patients, are respectively: tablet in treatment group, capsule treatment group and oral liquid treatment group; Wherein, in 174 examples in male's 112 examples, 32 examples of cough, 21 examples of chest pain, 19 examples of hemoptysis, 24 examples out of breath, 10 examples of heating, 6 examples of becoming thin; In women's 62 examples, 12 examples of cough, 10 examples of chest pain, 9 examples of hemoptysis, 7 examples out of breath, 8 examples of heating, 6 examples of becoming thin, 54 years old mean age;

Chinese patent medicine matched group: male's 87 examples in 126 examples, women's 39 examples; 42 examples of coughing, chest pain 30 examples, hemoptysis 29 examples, 16 examples out of breath, 5 examples of heating, 4 examples of becoming thin, 55 years old mean age.

Diagnostic criteria: according to clinical symptoms, sign and imaging examination, the one that meets following situations can be used as clinical diagnosis:

1, chest X-ray is found Pulmonary Isolated Nodules or swollen thing, jagged;

2, the high-risk group of pulmonary, has cough or bloody sputum, and chest X-ray is found Focal lesion, through positive antiinflammatory or the invalid or pathological changes increase person of antituberculosis therapy (2 weeks-4 weeks);

3, segmental pneumonia developed into segmental atelectasis in 2 months-3 months, or segmental atelectasis develops into full pulmonary atelectasis in a short time;

4, occur in a short time the side growth property bloody pleural fluid without other reasons, or a side volume bloody pleural fluid is accompanied pulmonary atelectasis person or pleural nodulations shape changer simultaneously;

5, obviously cough, out of breath, two lung millet appearances of chest films showed or diffuse lesion, can get rid of foxtail millet grain type pulmonary tuberculosis, pulmonary metastases, pulmonary mycosis person;

6, rabat is found pulmonary lump, with hilus pulumonis or vertical phrenic lymph nodes enlargement, and occurs that superior vena cava blocks, recurrent nerve paralysis symptom, or with metastasis shower.

Therapeutic Method:

In treatment by Chinese herbs group:

Tablet in treatment group: take the tablet of the embodiment of the present invention 1 preparation, every day 3 times, one time 4, within every 60 days, be 1 course for the treatment of;

Capsule treatment group: take the capsule of the embodiment of the present invention 2 preparation, every day 3 times, one time 2, within every 60 days, be a course for the treatment of;

Oral liquid treatment group: take the oral liquid of the embodiment of the present invention 3 preparations, every day 3 times, 30ml/ time every 60 days is a course for the treatment of.

Chinese patent medicine matched group: take celestial toad sheet, every day 3 times, each sheet 2, every 60 days is a course for the treatment of.

The standard of curative effect evaluation: before and after the treatment of making according to Ka Shi standards of grading (referring to table 2), life quality is as the standard of curative effect evaluation.

Table 2 Kamofsky standards of grading (physical situation score standard)

Muscle power situation	Score
		All are normal, without uncomfortable disease	100
Can carry out normal activity, have slight disease	90
		Can carry out normal activity reluctantly, have some Sxs	80
Life can be taken care of oneself, but can not maintain normal activity or heavy work	70
		Life can most ofly be taken care of oneself, but needs once in a while to want help	60
Need others more to help, and often need medical treatment and nursing	50
		Lose viability, need special treatment and help	40
Seriously lose viability, need to be in hospital, but temporarily without death threats	30
		Seriously ill, need to be in hospital and positive Supporting Therapy	20
Critically ill	10
		Dead	0

The evaluation methodology for the treatment of front and back life qualities (K): K1(is effective): after treatment, than raising before treatment >=20 minutes, K2(was effective): after treatment, than raising before treatment >=10 minutes, K3(was invalid): after treatment, than nothing before treatment, improve.

Therapeutic outcome:

Referring to table 3 and table 4, as can be seen from Table 3, adopt treatment by Chinese herbs pulmonary carcinoma of the present invention, with respect to Chinese patent medicine, on therapeutic effect, there is significant improvement; As can be seen from Table 4, adopt treatment by Chinese herbs pulmonary carcinoma of the present invention, with respect to Chinese patent medicine, treating significantly shortening on the course for the treatment of.

After table 3 liang group is treated respectively 4 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Effectively	Effective	Invalid	Effective and effective percentage
						Tablet in treatment group	58	18	6	34	41.3％
Capsule treatment group	58	17	9	32	44.8％
						Oral liquid treatment group	58	16	7	35	39.6％
Chinese patent drugs for treatment group	174	12	4	158	9.1％

Four groups, table 4 is treated respectively effective and effective number and time comparative example (%) after 4 courses for the treatment of

Group	Number of cases	The 1st course for the treatment of	The 2nd course for the treatment of	The 3rd course for the treatment of	The 4th course for the treatment of
						Tablet in treatment group	24	2（8.33％）	5（20.83％）	10（41.66％）	7（29.16％）
Capsule treatment group	26	1（3.84％）	7（26.92％）	10（38.46％）	8（30.76％）
						Oral liquid treatment group	23	1（4.34％）	6（26.08％）	8（34.78％）	8（34.78％）
Chinese patent drugs for treatment group	16	0（0％）	1（6.25％）	2（12.5％）	13（81.25％）

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; And 73 examples and Chinese patent drugs for treatment group effective and effective 16 routine patients efficiently individual quantity effective to treatment group follow up a case by regular visits to 1 year half simultaneously, result statistics, and in treatment group 73 examples, 1 case relapsed in effective 22 examples, recurs 5 examples in effective 51 examples, and relapse rate is 8.2%; 16 examples of the effective and efficiently individual quantity of Chinese patent drugs for treatment group, in 4 effective routine patients, recurrence 3 people, in effective 12 routine patients, recurrence 9 people, relapse rate 75%; Above-mentioned recurrence refer to patient treatment effect reach effective after, in 1 year half of following up a case by regular visits to, obviously there is the pulmonary carcinoma symptoms such as chest pain, hemoptysis or pulmonary lump increase before treatment.

Model case: Liu, male, 59 years old, chest pain, hemoptysis, heating, tumor are tired, pleura or vertical diaphragm, produce erratic chest dull pain dull pain, tumor corrodes thoracic wall rib or compressing intercostal nerves, and chest pain is sharply violent, and a little or local tenderness, and partly have breathing, cough, changing position and increase the weight of; A small amount of sputum mixed with blood repeatedly of normal persistence or discontinuity, wayward, during cancerous protuberance corrosion trunk, can cause large mouthful of spitting of blood, color is fresh; Generate heat often persistent, antibiotic therapy is invalid, companion's night sweat, and xerostomia, vexed, the symptoms such as feverish sensation in the palms and soles; Take the tablet of Chinese medicine preparation embodiment 1 of the present invention, every day 3 times, each 4, treat 2 months effectively, continue to take medicine 2 months effective, follow up a case by regular visits to not recurrence in 1 year half.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. a Chinese medicine composition for the treatment of pulmonary carcinoma, it is characterized in that, comprise following raw medicinal material: Herba Commelinae, sub-clarinet bacterium, Radix seu Herba Heterostemmatis equirolii, Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Cayatiae Japonicae, Fructus Canarii, Calyx Seu Fructus Physalis, Bulbus Fritillariae Cirrhosae, Radix Tinosporae, Herba Physalis pubescentis, Semen Oroxyli, Radix Scrophulariae, Chinese alpine rush, the Radix Rehmanniae, Cortex Lycii, Folium Pyrrosiae, Rhizoma Polygoni Cuspidati, Fructus Citri, Rhizoma et radix smilacis santis, Schizaea digitata (L.) Sw, Pumex, Flos Campsis, Herba Lycopodii, Herba Sidae Szechuensis, Caulis Bambusae In Taenia, Radix Asteris, Flos Farfarae, Nux Prinsepiae, Fructus Aristolochiae, Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

2. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Commelinae 15-25 part, sub-clarinet bacterium 10-30 part, Radix seu Herba Heterostemmatis equirolii 15-30 part, Herba Houttuyniae 10-25 part, Rhizoma Fagopyri Dibotryis 15-35 part, Herba Cayatiae Japonicae 15-30 part, Fructus Canarii 10-25 part, Calyx Seu Fructus Physalis 15-35 part, Bulbus Fritillariae Cirrhosae 10-25 part, Radix Tinosporae 10-20 part, Herba Physalis pubescentis 10-25 part, Semen Oroxyli 15-30 part, Radix Scrophulariae 15-35 part, Chinese alpine rush 10-25 part, Radix Rehmanniae 15-30 part, Cortex Lycii 15-35 part, Folium Pyrrosiae 10-25 part, Rhizoma Polygoni Cuspidati 10-30 part, Fructus Citri 15-30 part, Rhizoma et radix smilacis santis 15-35 part, Schizaea digitata (L.) Sw 10-25 part, Pumex 10-25 part, Flos Campsis 10-20 part, Herba Lycopodii 15-35 part, Herba Sidae Szechuensis 15-30 part, Caulis Bambusae In Taenia 15-30 part, Radix Asteris 10-25 part, Flos Farfarae 15-35 part, Nux Prinsepiae 15-20 part, Fructus Aristolochiae 15-20 part, Adeps Arctonyx collaris 10-25 part and Pluma Anas platyrhnchos 10-30 part.

3. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Commelinae 17-22 part, sub-clarinet bacterium 15-25 part, Radix seu Herba Heterostemmatis equirolii 17-25 part, Herba Houttuyniae 15-25 part, Rhizoma Fagopyri Dibotryis 20-35 part, Herba Cayatiae Japonicae 17-25 part, Fructus Canarii 17-25 part, Calyx Seu Fructus Physalis 17-30 part, Bulbus Fritillariae Cirrhosae 10-20 part, Radix Tinosporae 17-20 part, Herba Physalis pubescentis 10-20 part, Semen Oroxyli 18-25 part, Radix Scrophulariae 19-30 part, Chinese alpine rush 18-25 part, Radix Rehmanniae 20-30 part, Cortex Lycii 17-30 part, Folium Pyrrosiae 15-25 part, Rhizoma Polygoni Cuspidati 18-30 part, Fructus Citri 19-30 part, Rhizoma et radix smilacis santis 18-35 part, Schizaea digitata (L.) Sw 19-25 part, Pumex 16-20 part, Flos Campsis 17-20 part, Herba Lycopodii 17-30 part, Herba Sidae Szechuensis 18-25 part, Caulis Bambusae In Taenia 17-25 part, Radix Asteris 16-25 part, Flos Farfarae 20-35 part, Nux Prinsepiae 18-20 part, Fructus Aristolochiae 18-20 part, Adeps Arctonyx collaris 15-25 part and Pluma Anas platyrhnchos 20-30 part.

4. according to the Chinese medicine composition of the arbitrary described treatment pulmonary carcinoma of claim 1-3, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 18 parts of Herba Commelinaes, 17 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 17 parts of Herba Houttuyniae, 22 parts of Rhizoma Fagopyri Dibotryiss, 17 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 20 parts of Calyx Seu Fructus Physaliss, 15 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 15 parts of Herba Physalis pubescentis, 19 parts of Semen Oroxylis, 20 parts of Radix Scrophulariaes, 20 parts of Chinese alpine rush, 22 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 20 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 18 parts of Flos Campsiss, 19 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 18 parts of Caulis Bambusae In Taenia, 19 parts of Radix Asteriss, 20 parts of Flos Farfaraees, 18 parts of Nux Prinsepiae, 19 parts of Fructus Aristolochiaes, 20 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

5. according to the Chinese medicine composition of the arbitrary described treatment pulmonary carcinoma of claim 1-4, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 20 parts of Herba Commelinaes, 19 parts of sub-clarinet bacterium, 22 parts of Radix seu Herba Heterostemmatis equiroliis, 20 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 20 parts of Herba Cayatiae Japonicaes, 18 parts of Fructus Canariis, 25 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 18 parts of Radix Tinosporaes, 16 parts of Herba Physalis pubescentis, 20 parts of Semen Oroxylis, 25 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 18 parts of Folium Pyrrosiaes, 22 parts of Rhizoma Polygoni Cuspidati, 20 parts of Fructus Citris, 25 parts of Rhizoma et radix smilacis santis, 22 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 20 parts of Flos Campsiss, 25 parts of Herba Lycopodii, 20 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 18 parts of Radix Asteriss, 22 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 18 parts of Fructus Aristolochiaes, 25 parts of 17 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

6. according to the Chinese medicine of the arbitrary described treatment pulmonary carcinoma of claim 1-5, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 19 parts of Herba Commelinaes, 20 parts of sub-clarinet bacterium, 18 parts of Radix seu Herba Heterostemmatis equiroliis, 19 parts of Herba Houttuyniae, 25 parts of Rhizoma Fagopyri Dibotryiss, 22 parts of Herba Cayatiae Japonicaes, 20 parts of Fructus Canariis, 27 parts of Calyx Seu Fructus Physaliss, 17 parts of Bulbus Fritillariae Cirrhosae, 20 parts of Radix Tinosporaes, 18 parts of Herba Physalis pubescentis, 22 parts of Semen Oroxylis, 27 parts of Radix Scrophulariaes, 22 parts of Chinese alpine rush, 25 parts, the Radix Rehmanniae, 20 parts of Cortex Lycii, 17 parts of Folium Pyrrosiaes, 20 parts of Rhizoma Polygoni Cuspidati, 22 parts of Fructus Citris, 30 parts of Rhizoma et radix smilacis santis, 20 parts of Schizaea digitata (L.) Sw, 18 parts of Pumexs, 19 parts of Flos Campsiss, 27 parts of Herba Lycopodii, 22 parts of Herba Sidae Szechuensiss, 20 parts of Caulis Bambusae In Taenia, 22 parts of Radix Asteriss, 26 parts of Flos Farfaraees, 19 parts of Nux Prinsepiae, 20 parts of Fructus Aristolochiaes, 27 parts of 19 parts of Adeps Arctonyx collaris and Pluma Anas platyrhnchos.

7. according to the Chinese medicine composition of the arbitrary described treatment pulmonary carcinoma of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine composition is tablet, its preparation method comprises the following steps:

The first step, each raw medicinal material in described Chinese medicine composition is mixed in proportion, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85～95%, reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

8. according to the Chinese medicine composition of the arbitrary described treatment pulmonary carcinoma of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

9. the Chinese medicine composition for the treatment of pulmonary carcinoma according to claim 8, is characterized in that, when the dosage form of described Chinese medicine composition is oral liquid, its preparation method comprises the following steps:

10. according to the Chinese medicine composition of arbitrary described treatment pulmonary carcinoma in claim 1-9, it is characterized in that the dosage form of described Chinese medicine composition is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, syrup, fumigant, ointment, liniment, tincture, ointment, patch, suppository, plaster, gel or spray.