CN105663845A - Traditional Chinese medicine preparation for treating rosacea and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating rosacea and preparation method thereof Download PDF

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CN105663845A
CN105663845A CN201610125359.0A CN201610125359A CN105663845A CN 105663845 A CN105663845 A CN 105663845A CN 201610125359 A CN201610125359 A CN 201610125359A CN 105663845 A CN105663845 A CN 105663845A
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孙振芳
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Abstract

The invention provides a traditional Chinese medicine preparation for treating rosacea and a preparation method thereof. The preparation is prepared from the following medicinal raw materials: chien briggsia herb, dwarf elm leaves, pugionium cornutum, Japanese balanophora, diospyros cathayensi, herba swertiae davidi, hibiscus rosa-sinensis, homalocladium platycladum, erianthus arundinaceus, campsis grandiflora loisel, euonymus oxyphyllus, valeriana jatamansi jones, pinus tabulaeformis, lindernia ruellioides, canscora and humifuse euphorbia herb. The traditional Chinese medicine preparation combined with western medicines for treating rosacea has the beneficial effects of convenience in use, good treatment effect, no toxic or side effect, few adverse reactions and simple preparation process.

Description

A kind of Chinese medicine preparation treating rosacea and preparation method thereof
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation treating rosacea and preparation method thereof.
Background technology
Rosacea (rosacea), also known as acne rosacea, acne rosacea, is that one betides centrofacial chronic skin inflammation. Early manifestation is generation diffusivity kermesinus patch in the middle part of face, and the pimple that occurs together, pustule and telangiectasis, pachydermatosis occurs in late period. Its cause of disease is not yet fully apparent from. It is probably on the basis of seborrhea, owing to some has the effect of factor, as Facial vascular relax contracting nervous disorder, blood capillary permanent enlargement, digestive tract function obstacle, endocrine function imbalance, Nervous and Mental Factors, focal infection, be addicted to drink, the stimulation etc. of maror causes local physiological and pathological change. It is believed that the stimulation of the vermiform mite colonized in pilosebaceous unit (i.e. demodex folliculorum), the inflammation that its metabolite and Excreta cause is the important pathogenic factors of rosacea.
Primary disease is often sent out in middle age, women is more, but that be in a bad way is often male patient, be apt to occur in the middle part of face, nose and dilator naris, also can extend to two cheeks, jaw portion and forehead, the course of disease is through slowly, the permanent person of stadium can cause nose hypertrophy, forming the tuberosity protuberance differed in size, surface relief is uneven, is called pachydermatosis. The pathological development of rosacea is divided into three periods, and the feature of its clinical manifestation is as follows: 1. erythema and the telangiectasis phase: slight person only has telangiectasis, local skin flushing, and oils and fats is many, and surface is greasy shinny, can involve buccal later. 2. the pimple phase: often accompany chronic inflammatory disease on erythema and telangiectatic basis, have circle, kermesinus, syringe needle is to the edemous hair follicle pimple of Semen Glycines size and pustule. 3. loose phase (also known as the pachydermatosis phase): nose sebaceous gland and connective tissue proliferation, nose, the wing of nose are loose, form the nodositas protuberance differed in size, surface irregularity, and telangiectasis is notable, and follicular orifice expands, and the current period is rare.
Motherland's medical science Jing-Yue Complete Works cloud: " rosacea is steamed by lung meridian heat in blood, secondary chance the exterior tightened by pathogenic windcold, and blood stasis stagnates and forms, therefore black after first purple. " errors in Medicine Corrected being emphasized, primary disease is caused by stagnation of QI-blood, advocates to invigorate blood circulation with sensible. Between twenty and fifty QI and blood Fang Gang, heat in blood smokes lung or because being addicted to drink, or preference for fat and sweet food savoury, helps a liter stomach-fire, lung stomach accumulated heat, stifling face, and raw erythema, pimple, pustule. Again because of the exterior tightened by pathogenic windcold, stagnation of QI-blood, cause formation anything superfluous or useless.
Summary of the invention
The technical problem to be solved is in that, utilizes the theory of Chinese medical science that China is traditional, it is provided that the Chinese medicine preparation and preparation method thereof of a kind of determined curative effect and the little treatment rosacea of toxic action.
In order to solve above-mentioned technical problem; the invention provides a kind of Chinese medicine preparation treating rosacea, described Chinese medicine preparation includes following raw medicinal material: Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis, Herba Swertiae davidi, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis, Cortex seu Radix Euonymi oxyphyllae, Rhizoma valerianae latifoliae, Ramulus Pini massonianae, Lindernia ruellioides (Colsm.) Pennell, Herba Canscorae and Herba Euphorbiae Humifusae.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Briggsiae Chienii 10～20 parts, Folium ulmi pumilae 15～30 parts, Herba Pugionii Cornuti 30～40 parts, Herba balanophorae japonicae 15～25 parts, Radix Diospyroris foochowensis 5～15 parts, Herba Swertiae davidi 10～20 parts, Flos Hibisci Rosae-Sinensis 5～15 parts, Herba Homalocladii Platycladii 30～40 parts, Radix sacchari arundinacei 25～40 parts, Radix campsis 10～20 parts, Cortex seu Radix Euonymi oxyphyllae 10～20 parts, Rhizoma valerianae latifoliae 20～35 parts, Ramulus Pini massonianae 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 5～20 parts, Herba Canscorae 20～30 parts and Herba Euphorbiae Humifusae 25～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Briggsiae Chienii 15～20 parts, Folium ulmi pumilae 25～30 parts, Herba Pugionii Cornuti 35～40 parts, Herba balanophorae japonicae 20～25 parts, Radix Diospyroris foochowensis 10～15 parts, Herba Swertiae davidi 15～20 parts, Flos Hibisci Rosae-Sinensis 5～10 parts, Herba Homalocladii Platycladii 30～35 parts, Radix sacchari arundinacei 30～35 parts, Radix campsis 10～15 parts, Cortex seu Radix Euonymi oxyphyllae 15～20 parts, Rhizoma valerianae latifoliae 25～30 parts, Ramulus Pini massonianae 20～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Herba Canscorae 25～30 parts and Herba Euphorbiae Humifusae 30～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Briggsiae Chienii 20 parts, Folium ulmi pumilae 26 parts, Herba Pugionii Cornuti 38 parts, Herba balanophorae japonicae 21 parts, Radix Diospyroris foochowensis 15 parts, Herba Swertiae davidi 16 parts, Flos Hibisci Rosae-Sinensis 10 parts, Herba Homalocladii Platycladii 32 parts, Radix sacchari arundinacei 35 parts, Radix campsis 12 parts, Cortex seu Radix Euonymi oxyphyllae 19 parts, Rhizoma valerianae latifoliae 26 parts, Ramulus Pini massonianae 24 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Herba Canscorae 28 parts and Herba Euphorbiae Humifusae 32 parts.
When the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 4～6 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders;
3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis and Herba Swertiae davidi are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby; It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C;
Second step, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis and Cortex seu Radix Euonymi oxyphyllae are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30;
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule.
Beneficial effects of the present invention: Chinese medicine preparation of the present invention associating western medicine rosacea, easy to use, therapeutic effect is better, has no side effect and untoward reaction, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation treating rosacea, Chinese medicine preparation includes following raw medicinal material: Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis, Herba Swertiae davidi, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis, Cortex seu Radix Euonymi oxyphyllae, Rhizoma valerianae latifoliae, Ramulus Pini massonianae, Lindernia ruellioides (Colsm.) Pennell, Herba Canscorae and Herba Euphorbiae Humifusae.
The pharmacology of various raw medicinal materials is as follows:
Herba Briggsiae Chienii: [source] medical material Ji Yuan: for root or the herb of the thick cylinder lettuce tongue in Anhui, Gesneriaceae Zhejiang. [nature and flavor] mildly bitter flavor; Property is put down. [function cures mainly] expelling pathogenic wind from the body surface; Invigorate blood circulation eliminating carbuncle. Main headache due to common cold; Impairment caused by overstrain; Muscles and bones is ached; Ulcerative carbuncle; Innominate toxic swelling. [extracts] " China's book on Chinese herbal medicine "
Folium ulmi pumilae: [source] medical material Ji Yuan: for the leaf of Ulmaceae elm. [nature and flavor] are sweet; Property is put down. [function cures mainly] clearing away heat and promoting diuresis; Calm the nerves; Expelling phlegm for arresting cough. Main edema; Dysuria; Stranguria caused by urinary stone; Turbid urine; Insomnia; Summer-heat is stranded vexed; Abundant expectoration is coughed; Wine (looks into skin) nose. [each discussion] supplement to the Herbal: consumer edema. [extracts] " China's book on Chinese herbal medicine "
Herba Pugionii Cornuti: [another name] husky Radix Raphani, husky Chinese cabbage, Herba Pugionii Cornuti dish, mountain Luo Shabu. [source] medical material Ji Yuan: for crucifer Herba Pugionii Cornuti, the few mustard of axe wing herb. [nature and flavor] are pungent; Temperature. [return through] heart; Lung; Stomach warp. [function cures mainly] circulation of qi promoting; Pain relieving; Help digestion; Removing toxic substances. Main fullness and distention in the chest and hypochondrium; Dyspepsia; Alimentary toxicosis. [each discussion] " Inner Mongol Chinese herbal medicine ": circulation of qi promoting, pain relieving, helps digestion, removing toxic substances, controls dyspepsia, fullness and distention in the chest and hypochondrium, alimentary toxicosis. [extracts] " China's book on Chinese herbal medicine "
Herba balanophorae japonicae: [another name] Flos puerariae lobatae dish, Pueraria lobota breast, Balaenoptera borealis Lesson, screw rise, Pueraria lobota bacterium, red scarlet bloodlily, Herba balanophorae japonicae medicine, bacterium rattan bacterium, Rhizoma Paridis, red winter wild rice, floor file is bloomed, do not lift one's head in remote mountains, Graptopelaum Paraguayense, soil conscience, angle bacterium, corner piece, Chang bacterium, Fructus Pyracanthae, Herba Orobanches, ball fringe Balaenoptera borealis Lesson. [source] medical material Ji Yuan: for the herb of the red winter Balaenoptera borealis Lesson of Balanophoraceae plant. [nature and flavor] are bitter; Puckery; Cold in nature. [return through] lung; Large intestine channel. [function cures mainly] cooling blood for hemostasis; Heat-clearing and toxic substances removing. Main cough spitting of blood; Metrorrhagia; Discharging fresh blood stool; Swelling and pain of hemorrhoid; Prunus mume (sieb.) sieb.et zucc. poison; Treat skin ulcer; Child penis swells. [extracts] " China's book on Chinese herbal medicine "
Radix Diospyroris foochowensis: [another name] wild kaki persimmon root. [source] medical material Ji Yuan: for the root of Ebenaceae plant crow Fructus Kaki. Gathering and store: 9～November excavates, cleaning, section is dried.[nature and flavor] are bitter; Puckery; Cold nature. [function cures mainly] clearing away lung-heat; Cooling blood for hemostasis; Promoting the circulation of QI to induce diuresis. Main cough due to lung-heat; Spit blood; Hemorrhoidal hamorrhage; Hemorrhoidal bleeding; The swollen abdominal distention of water; Furuncle; Burn. [each discussion] 1. " classifies herbal ": controlling gas disease, pellet stops, tympanites. 2. " conventional glossary of Herbs and Drugs among the people ": clearing away heat and cooling blood. Control haematemesis, hemorrhoid. 3. " Traditional Chinese Medicine in Sichuan will ": dehumidifying, diuretic, detumescence. Control toothache. 4. " Chongqing medical herbs ": control discharging fresh blood stool, cough due to lung-heat. [extracts] " China's book on Chinese herbal medicine "
Herba Swertiae davidi: [source] medical material Ji Yuan: for the herb of Gentianaceae Herba Swertiae bimaculatae. [nature and flavor] are bitter; Cool in nature. [return through] lung meridian. [function cures mainly] heat-clearing and toxic substances removing; Dampness removing. Main jaundice due to damp-heat; Cough due to lung-heat; Laryngopharynx swelling and pain; Toothache; Dysentery; Urinary tract infection; Suppurative osteomyelitis; Conjunctivitis; Adnexitis; Pelvic inflammatory disease; Herpes zoster; Scabies sore. [each discussion] " Chinese herbal medicine is commonly used in Sichuan ": clearing away lung-heat, parasite killing. Harnessing the Yellow River subcutaneous ulcer, larynx is red and swollen, malignant boil scabies. [extracts] " China's book on Chinese herbal medicine "
Flos Hibisci Rosae-Sinensis: [another name] is taken, Skapanthus C.Y.Wu et H.W.Li,nom.nov., ZHUANGYUANHONG. [source] medical material Ji Yuan: for the flower of Malvaceae plant Hibiscus rosasinensis. [nature and flavor] are sweet; Light; Flat. [return through] heart; Lung; Liver; Spleen channel. [function cures mainly] lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances. Main cough due to lung-heat; Spitting of blood; Epistaxis; Metrorrhagia; Leucorrhea; Dysentery; Reddish and whitish turbid urine; Carbuncle skin infection. [each discussion] 1. " south of the Five Ridges gather medicinal herbs record ": clearing away lung-heat, goes phlegm-fire, reason cough. 2. " Luchuan book on Chinese herbal medicine ": removing pathogenic heat from blood and toxic substance from the body. Control heat in blood, epistaxis, pruritus, skin infection. [extracts] " China's book on Chinese herbal medicine "
Herba Homalocladii Platycladii: [another name] fernleaf hedge bamboo, centipede mountain grass, university degree Caulis et Folium Pothi Repentis, mottled bamboo are similar, cold avoids bamboo, goose river grass. [source] medical material Ji Yuan: for the herb of polygonaceae plant Herba Homalocladii Platycladii. [nature and flavor] are sweet; Light; Property is put down. [return through] liver; Lung meridian. [function cures mainly] heat-clearing and toxic substances removing; Blood stasis removing is subsided a swelling. Main swollen ulcer drug; Traumatic injury; Serpentis; Insect bite is hindered. [each discussion] " Quanzhou book on Chinese herbal medicine ": heat-clearing and toxic substances removing, moves back Huang detumescence, promoting the circulation of blood blood stasis removing, tissue regeneration promoting pain relieving. Control swollen ulcer drug, traumatic injury, venom. [extracts] " China's book on Chinese herbal medicine "
Radix sacchari arundinacei: [another name] is close greatly, fragrant plant thatch. [source] medical material Ji Yuan: for the root of grass Radix sacchari arundinacei. [nature and flavor] are sweet; Talk; Flat. [function cures mainly] promoting blood circulation to restore menstrual flow; Sensible diuretic. Main traumatic injury; Muscles and bones wind pain; Amenorrhea; Menoxenia; Edema distention of the abdomen caused by various parasites. [each discussion] 1. Cui Yu stannum " cuisine canon ": main continuous wound absolutely, invigorating middle warmer heavily fortified point muscles and bones, physical strength profiting, good order becomes to. 2. " good right book on Chinese herbal medicine ": main improving eyesight, many Shiqis meat, QI invigorating, help negative and positive. [extracts] " China's book on Chinese herbal medicine "
Radix campsis: [another name] Radix Campsis. [source] medical material Ji Yuan: reach the clouds for Bignoniaceae plant or the root reached the clouds in America. [nature and flavor] sweet in the mouth; Pungent; Cold in nature. [return through] liver; Spleen; Kidney channel. [function cures mainly] cooling blood, expelling wind; Promoting blood circulation to remove obstruction in the collateral. Main blood hot air wind producing; Itching over the body; Rubella; Waist foot is unsuccessful; Gout; Rheumatic arthralgia; Traumatic injury. [each discussion] " Zhiwu Mingshi Tukao ": can promoting the circulation of blood. [extracts] " China's book on Chinese herbal medicine "
Cortex seu Radix Euonymi oxyphyllae: [another name] cone winged euonymus, five ribs. [source] medical material Ji Yuan: for the root of Celastraceae plant Cortex seu Radix Euonymi oxyphyllae, root bark and peel of stem. [nature and flavor] are bitter;Pungent; Flat. [return through] heart; Large intestine; Liver Channel. [function cures mainly] expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Promoting diuresis to remove toxic substance. Main air pain of dampness syndrome; Dysentery; Have loose bowels; Dysmenorrhea; Amenorrhea; Injury and bone fracture; Foot gas; Edema; Scrotum pruritus due to damp pathogen; Sore swollen toxin. [each discussion] Anhui " a collection of selected materials of folk prescription medical herbs ": blood circulation promoting competent silt, stimulates the menstrual flow and relieves oedema or abdominal distension through diuresis or purgation. Controlling that the traumatic injury stasis of blood is stagnant has a pain, women feels cold amenorrhea stomachache, ascites tympanites. [extracts] " China's book on Chinese herbal medicine "
Rhizoma valerianae latifoliae: [another name] Herba Asari, Devil Frown, lotus of nourishing blood, smelly medicine, Wu Can, rescue greatly. [source] medical material Ji Yuan: for the rhizome of Valerianaceae plant Rhizoma valerianae latifoliae. [nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature. [function cures mainly] regulate the flow of vital energy and in, dispelling cold and removing dampness; Promoting blood circulation and detumescence. Main abdominal distention; Tell and have loose bowels; Infantile malnutrition; Anemofrigid-damp arthralgia; Limb air water swells; Menoxenia; Traumatic injury; Furuncle. [each discussion] be " Guizhou side's medicine collection among the people " 1.: calm, pleasant, helps digestion. Control abdominal distention and pain, peratodynia. Control again infantile convulsion. 2. " Guangxi Chinese medicinal herbal ": dehumidifying cold expelling, control beriberi edema, taste dyspepsia, external application furuncle. 3. " Shaanxi Chinese herbal medicine ": invigorate blood circulation, regulating menstruation. Control headache, arthralgia. menoxenia, traumatic injury, furuncle. [extracts] " China's book on Chinese herbal medicine "
Ramulus Pini massonianae: [another name] pinaster stamen, Song Jian, the pinaster tip. [source] comes from " the southern regions of the Yunnan Province book on Chinese herbal medicine ". [source] medical material Ji Yuan: the twig for pinaceae plant pinus yunnanensis faranch, Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen, Pinus massoniana Lamb etc. is most advanced and sophisticated. [nature and flavor] are bitter; Puckery; Cool in nature. [function cures mainly] expelling wind and removing dampness; Promoting blood circulation and detumescence, heat-clearing and toxic substances removing. Main air pain of dampness syndrome; Stranguria; Turbid urine; Traumatic injury; Acute mastitis; Animal bite; Nyctalopia. [each discussion] be " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: network of passing through, only pains in the penis, only turbid urine. Controlling stranguria marked by chyluria and ache unbearably painful person, mill watery wine takes it. Five types of stranguria all can take. 2. " Zhejiang conventional medical herbs among the people ": invigorating blood circulation analgesia, arresting seminal emission. [extracts] " China's book on Chinese herbal medicine "
Lindernia ruellioides (Colsm.) Pennell: [another name] Herba Linderniae ruellioidis, Radix Euonymi japonici, small size tiger tongue Huang, tiger tongue Herba pteridis vittatae, field jasmine, underground tea, Testudinis medicine, saw sickle grass, Tian Suxiang, Herba Linderniae anagallis, snake melon perfume, Herba sagittariae pygmaeae Huang, earrings grass. [source] medical material Ji Yuan: for the herb of goatweed Lindernia ruellioides (Colsm.) Pennell. [nature and flavor] sweet in the mouth; Light; Property is put down. [function cures mainly] vital energy regualting and blood circulation-promoting; Removing toxic substances and promoting subsidence of swelling. Main menoxenia; Dysmenorrhea; Amenorrhea; Stomachache; Acute mastitis; Scrofula; Traumatic injury; Serpentis lyssodexis. [extracts] " China's book on Chinese herbal medicine "
Herba Canscorae: [another name] wears money grass, top heart-wind syndrome, lion grass, Herba Andrographis. [source] medical material Ji Yuan: for the herb of gentianaceae plant Herba Canscorae. [nature and flavor] are micro-sweet; Micro-hardship; Cool in nature. [return through] lung; Spleen; Stomach; Liver Channel. [function cures mainly] heat-clearing and toxic substances removing; Vital energy regualting and blood circulation-promoting. Main cough due to lung-heat; Hepatitis; Leptospirosis; Chest pain; Stomachache; Traumatic injury; Venom. [each discussion] 1. " Guangxi Chinese herbal medicine ": regulate the flow of vital energy, pain relieving, cough-relieving. Control cough due to lung-heat, heart peratodynia, venom. 2. " Guangxi practicality Chinese herbal medicine newly selects ": cool liver and gall, promoting blood circulation and stopping pain. Harness the Yellow River pox, hepatitis, chest pain, stomachache, internal traumatic injury. [extracts] " China's book on Chinese herbal medicine "
Herba Euphorbiae Humifusae: [another name] Euphorbia helioscopia, Hydrocotyle sibthorpioides, floor file are red, Herba Chenopodii Hybridi, sleeping egg grass, the sleeping egg of passeris montani saturati, the sleeping egg of small worm. [source] this product is the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae or Herba Euphorbiae supinae.[nature and flavor] are pungent, flat. [return through] returns liver, large intestine channel. [function cures mainly] heat-clearing and toxic substances removing, cooling blood for hemostasis. For dysentery, have loose bowels, hemoptysis, hematuria, have blood in stool, metrorrhagia, furuncle carbuncle. [extracts] " Chinese Pharmacopoeia "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Briggsiae Chienii 10～20 parts, Folium ulmi pumilae 15～30 parts, Herba Pugionii Cornuti 30～40 parts, Herba balanophorae japonicae 15～25 parts, Radix Diospyroris foochowensis 5～15 parts, Herba Swertiae davidi 10～20 parts, Flos Hibisci Rosae-Sinensis 5～15 parts, Herba Homalocladii Platycladii 30～40 parts, Radix sacchari arundinacei 25～40 parts, Radix campsis 10～20 parts, Cortex seu Radix Euonymi oxyphyllae 10～20 parts, Rhizoma valerianae latifoliae 20～35 parts, Ramulus Pini massonianae 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 5～20 parts, Herba Canscorae 20～30 parts and Herba Euphorbiae Humifusae 25～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Briggsiae Chienii 15～20 parts, Folium ulmi pumilae 25～30 parts, Herba Pugionii Cornuti 35～40 parts, Herba balanophorae japonicae 20～25 parts, Radix Diospyroris foochowensis 10～15 parts, Herba Swertiae davidi 15～20 parts, Flos Hibisci Rosae-Sinensis 5～10 parts, Herba Homalocladii Platycladii 30～35 parts, Radix sacchari arundinacei 30～35 parts, Radix campsis 10～15 parts, Cortex seu Radix Euonymi oxyphyllae 15～20 parts, Rhizoma valerianae latifoliae 25～30 parts, Ramulus Pini massonianae 20～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Herba Canscorae 25～30 parts and Herba Euphorbiae Humifusae 30～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Briggsiae Chienii 20 parts, Folium ulmi pumilae 26 parts, Herba Pugionii Cornuti 38 parts, Herba balanophorae japonicae 21 parts, Radix Diospyroris foochowensis 15 parts, Herba Swertiae davidi 16 parts, Flos Hibisci Rosae-Sinensis 10 parts, Herba Homalocladii Platycladii 32 parts, Radix sacchari arundinacei 35 parts, Radix campsis 12 parts, Cortex seu Radix Euonymi oxyphyllae 19 parts, Rhizoma valerianae latifoliae 26 parts, Ramulus Pini massonianae 24 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Herba Canscorae 28 parts and Herba Euphorbiae Humifusae 32 parts.
When the dosage form of described Chinese medicine preparation is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 4～6 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders;
3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
When the dosage form of described Chinese medicine preparation is capsule, it comprises the following steps:
The first step, Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis and Herba Swertiae davidi are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby; It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C;
Second step, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis and Cortex seu Radix Euonymi oxyphyllae are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30;
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1: powder prepared by the present invention
Take Herba Briggsiae Chienii 200g, Folium ulmi pumilae 260g, Herba Pugionii Cornuti 380g, Herba balanophorae japonicae 210g, Radix Diospyroris foochowensis 150g, Herba Swertiae davidi 160g, Flos Hibisci Rosae-Sinensis 100g, Herba Homalocladii Platycladii 320g, Radix sacchari arundinacei 350g, Radix campsis 120g, Cortex seu Radix Euonymi oxyphyllae 190g, Rhizoma valerianae latifoliae 260g, Ramulus Pini massonianae 240g, Lindernia ruellioides (Colsm.) Pennell 120g, Herba Canscorae 280g and Herba Euphorbiae Humifusae 320g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 90% relative to mixture quality 6 times, is heated to reflux 3 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 95% relative to described medicinal residues quality 3 times, be heated to reflux 3 hours, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 orders;
3rd step, adds the starch relative to its quality 2.7 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
Embodiment 2: capsule prepared by the present invention
Take Herba Briggsiae Chienii 170g, Folium ulmi pumilae 300g, Herba Pugionii Cornuti 360g, Herba balanophorae japonicae 250g, Radix Diospyroris foochowensis 120g, Herba Swertiae davidi 180g, Flos Hibisci Rosae-Sinensis 70g, Herba Homalocladii Platycladii 350g, Radix sacchari arundinacei 330g, Radix campsis 150g, Cortex seu Radix Euonymi oxyphyllae 160g, Rhizoma valerianae latifoliae 280g, Ramulus Pini massonianae 210g, Lindernia ruellioides (Colsm.) Pennell 150g, Herba Canscorae 260g and Herba Euphorbiae Humifusae 340g.
Its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis and Herba Swertiae davidi are mixed in described ratio, add the water extraction volatile oil relative to 5 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 80 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, standby; It is the clear paste of 1.16 that aqueous extract is separately concentrated into relative density when 60 DEG C;
Second step, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis and Cortex seu Radix Euonymi oxyphyllae are mixed in described ratio, add relative to the alcohol reflux that mixture 6 times amount determining alcohol is 85% 4 times, each 3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20, standby;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 9 times amount water, boil 8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28;
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 65 DEG C of reduced vacuum dry, and get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, adding 5 weight portion carboxymethyl starch sodium, 36 weight starch mix homogeneously, adding 150 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, subsequently relative to the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, add 4 weight portion magnesium stearate, be then charged in gelatine capsule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20-36g, carries out acute toxicity test. Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 8.83g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.15 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll. Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal. Powder LD50 > 44.15 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 88.3 crude drugs/kg/ day. The Chinese medicine clinical application amount of the present invention be 8.36g crude drug/day/people, adult body weight in 60KG, average dosage is 0.139g crude drug/kg/ day. By weighing machine: 635 times that the dosis tolerata of the Chinese medicine of mice (average weight with 28g) the oral administration gavage present invention is quantity. Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 powder of the present invention to three groups of mices (often group 20) by 13.27,25.43 and 42.35g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing. Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical data:
Case selection: all 130 example cases derive from this Out-patient Department and the patient being in hospital. All patients are randomly divided into two groups, treatment group 65 example and matched group 65 example. Treatment group 65 example, male 28 examples, female 37 example; 22～50 years old age; The course of disease 6 months～4 years; Wherein erythema phase 21 example, pimple phase 38 example, pachydermatosis phase 6 example. Matched group 65 example, male 27 examples, female 38 example; 23～52 years old age; The course of disease 6 months～3 years 8 months; Wherein erythema phase 22 example, pimple phase 38 example, pachydermatosis phase 5 example. Treatment group and matched group no significant difference (P≤0.01) in sex, age, the course of disease and clinical symptoms, have comparability.
Diagnostic criteria: formulate according to the diagnostic criteria of rosacea in " clinical disease diagnosis and curative effect judging standard " that hospital associate of Hunan Province writes.
One, typical case's skin lesion is congestive erythema, telangiectasis, recurrent pimple and the pustule that nose dough-making powder central part occurs.
Two, middle age morbidity, chronic process.
Rosacea was divided into for 3 phases by its evolution:
(1) erythema phase rosacea: from the beginning of for erythema fugax, erythema becomes apparent from after irritable food or time excited especially on the feed, and with the passing of time erythema is persistent, and blood capillary is dendroid expansion.
(2) papulopustule phase rosacea: on erythema basis, may occur in which pimple or pustule, and skin lesion is inconsistent with hair follicle.
(3) pachydermatosis phase rosacea: the permanent person of the state of an illness, nose may occur in which multiple tuberosity, merges mutually, surface irregularity, and nose is loose, and pore substantially expands, and blood capillary is significantly expanded, crisscross, forms pachydermatosis.
Therapeutic Method:
Matched group: oral vitamin B2Sheet 10mg, 3 times/d, vitamin B6Sheet 10mg, 3 times/d; Effect of Oral Metronidazole sheet 0.2g, 3 times/d, changes 0.2g into after 2 weeks, 2 times/d; Oral tetracycline sheet 0.25g, 4 times/d, changes 0.25g into after 2 weeks, 2 times/d; 15 days courses for the treatment of, after 2 courses for the treatment of, judge curative effect.
Treatment group: on matched group western medicine basis, simultaneously oral Chinese medicine embodiment 1 powder of the present invention, each 20g, every day 3 times; 15 days courses for the treatment of, after 2 courses for the treatment of, judge curative effect.
Curative effect judging standard: cure: contrafluxion erythema, telangiectasis, pimple, pustule, tuberosity disappear, and recover true colours. Take a turn for the better: contrafluxion erythema, telangiectasis, pimple, pustule, tuberosity is obviously reduced or color of the leather turns light. Invalid: to compare with before treatment without substantially changing or increasing the weight of.
Therapeutic outcome: two groups treat 30 days respectively after, statistical result is referring to table 1.
Clinical efficacy comparison (unit: example) after treating 30 days respectively organized by 1 liang of table
Group Number of cases Cure Take a turn for the better Invalid Total effective rate
Treatment group 65 41 18 6 59 (90.77%)
Matched group 65 24 23 18 47 (72.31%)
As it can be seen from table 1 treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment rosacea, relative to matched group, on therapeutic effect, have and be markedly improved.
Untoward reaction: matched group 65 example patient, in therapeutic process, there are the gastrointestinal upset such as Nausea and vomiting in 10 example patients, and headache, dizziness occur in 4 examples, hepatic and renal function injure or other untoward reaction all do not occur. , in therapeutic process, all there is not hepatic and renal function injure or other untoward reaction in treatment group 65 example patient.
Concrete case: Chen, man, 27 years old, patient nose surface was covered with pinprick granulation of a size, therefrom came up once the oils and fats squeezing a visible grain ecru with hands, if having eaten Fructus Capsici or having drunk, the swelling of nose will become serious. Nose is gone back president's little red pimple one by one sometimes, touches a little pain with hands, if pimple has broken the inside has pus and blood outflow. Clinical definite is rosacea (the papulopustule phase). Give oral vitamin B210mg, 3 times/d, vitamin B610mg, 3 times/d; Effect of Oral Metronidazole 0.2g, 3 times/d, changes 0.2g into after 2 weeks, 2 times/d; Oral tetracycline 0.25g, 4 times/d, changes 0.25g into after 2 weeks, 2 times/d; Oral Chinese medicine embodiment 1 powder of the present invention, each 20g, every day 3 times simultaneously; After treating 25 days, contrafluxion erythema, telangiectasis, pimple, pustule, tuberosity disappear, and recover true colours, cure, and follow up a case by regular visits to 6 months without recurrence.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement or the new method that limit other forms. Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status. But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above. But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese medicine preparation treating rosacea; it is characterized in that, described Chinese medicine preparation includes following raw medicinal material: Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis, Herba Swertiae davidi, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis, Cortex seu Radix Euonymi oxyphyllae, Rhizoma valerianae latifoliae, Ramulus Pini massonianae, Lindernia ruellioides (Colsm.) Pennell, Herba Canscorae and Herba Euphorbiae Humifusae.
2. Chinese medicine preparation as claimed in claim 1; it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 10～20 parts, Folium ulmi pumilae 15～30 parts, Herba Pugionii Cornuti 30～40 parts, Herba balanophorae japonicae 15～25 parts, Radix Diospyroris foochowensis 5～15 parts, Herba Swertiae davidi 10～20 parts, Flos Hibisci Rosae-Sinensis 5～15 parts, Herba Homalocladii Platycladii 30～40 parts, Radix sacchari arundinacei 25～40 parts, Radix campsis 10～20 parts, Cortex seu Radix Euonymi oxyphyllae 10～20 parts, Rhizoma valerianae latifoliae 20～35 parts, Ramulus Pini massonianae 15～25 parts, Lindernia ruellioides (Colsm.) Pennell 5～20 parts, Herba Canscorae 20～30 parts and Herba Euphorbiae Humifusae 25～35 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2; it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 15～20 parts, Folium ulmi pumilae 25～30 parts, Herba Pugionii Cornuti 35～40 parts, Herba balanophorae japonicae 20～25 parts, Radix Diospyroris foochowensis 10～15 parts, Herba Swertiae davidi 15～20 parts, Flos Hibisci Rosae-Sinensis 5～10 parts, Herba Homalocladii Platycladii 30～35 parts, Radix sacchari arundinacei 30～35 parts, Radix campsis 10～15 parts, Cortex seu Radix Euonymi oxyphyllae 15～20 parts, Rhizoma valerianae latifoliae 25～30 parts, Ramulus Pini massonianae 20～25 parts, Lindernia ruellioides (Colsm.) Pennell 10～15 parts, Herba Canscorae 25～30 parts and Herba Euphorbiae Humifusae 30～35 parts.
4. the Chinese medicine preparation as described in claims 1 to 3; it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Briggsiae Chienii 20 parts, Folium ulmi pumilae 26 parts, Herba Pugionii Cornuti 38 parts, Herba balanophorae japonicae 21 parts, Radix Diospyroris foochowensis 15 parts, Herba Swertiae davidi 16 parts, Flos Hibisci Rosae-Sinensis 10 parts, Herba Homalocladii Platycladii 32 parts, Radix sacchari arundinacei 35 parts, Radix campsis 12 parts, Cortex seu Radix Euonymi oxyphyllae 19 parts, Rhizoma valerianae latifoliae 26 parts, Ramulus Pini massonianae 24 parts, Lindernia ruellioides (Colsm.) Pennell 12 parts, Herba Canscorae 28 parts and Herba Euphorbiae Humifusae 32 parts.
5. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 4～6 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders;
3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
6. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis and Herba Swertiae davidi are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby; It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C;
Second step, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis and Cortex seu Radix Euonymi oxyphyllae are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30;
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule.
7. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is powder, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, adds the ethanol that determining alcohol is 85%～95% relative to mixture quality 4～6 times, is heated to reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85%～95% relative to described medicinal residues quality 2～3 times, be heated to reflux 1～3 hour, extract, filter and obtain the second extracting solution; First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, dry, it is thus achieved that dry cream;
Second step, is placed in super micron mill by the dry cream that the first step obtains and pulverizes 1～2 hour, pulverizes, sieves, it is thus achieved that the micropowders of 300 order～400 orders;
3rd step, adds the starch relative to its quality 2～4 times in the micropowders obtained by second step, mixing, it is thus achieved that powder.
8. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, Herba Briggsiae Chienii, Folium ulmi pumilae, Herba Pugionii Cornuti, Herba balanophorae japonicae, Radix Diospyroris foochowensis and Herba Swertiae davidi are mixed in described ratio, add the water extraction volatile oil relative to 4～6 times of mixture, the volatile oil beta-cyclodextrin inclusion compound that will obtain, the ratio of volatile oil and beta-schardinger dextrin-is 1: 3～6, stirs 75 minutes～90 minutes, temperature 30 DEG C～50 DEG C, obtain volatile oil clathrate compound, standby;It is the clear paste of 1.15～1.17 that aqueous extract is separately concentrated into relative density when 60 DEG C;
Second step, Flos Hibisci Rosae-Sinensis, Herba Homalocladii Platycladii, Radix sacchari arundinacei, Radix campsis and Cortex seu Radix Euonymi oxyphyllae are mixed in described ratio, add relative to the alcohol reflux that mixture 6～8 times amount determining alcohol is 80%～90% 3～5 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into relative density when 60 DEG C is the clear paste of 1.20～1.22, standby;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8～10 times amount water, boil 6～8 hours, filter, and being concentrated into relative density when 65 DEG C is the clear paste of 1.28～1.30;
4th step, mixes the clear paste of the first step, second step, the 3rd step, and 60 DEG C～70 DEG C reduced vacuum dry, and get dry extract powder;
5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is sufficiently mixed, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 5～8 weight portion carboxymethyl starch sodium, 10～50 weight starch mix homogeneously, adding 150～200 weight portion determining alcohols is 80%～90% alcohol granulation, dry, granulate, it is subsequently added the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3～5 weight portion magnesium stearate, are then charged in gelatine capsule.
CN201610125359.0A 2016-03-06 2016-03-06 Traditional Chinese medicine preparation for treating rosacea and preparation method thereof Pending CN105663845A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836409A (en) * 2012-09-05 2012-12-26 张梅 Traditional Chinese medicine for treating postpartum lochiorrhea and preparation method
CN103933425A (en) * 2014-04-11 2014-07-23 胡海波 Traditional Chinese medicine composition for treating lung cancer and preparation method thereof
CN104288322A (en) * 2014-10-09 2015-01-21 四川金堂海纳生物医药技术研究所 Oral medicament for treating rosacea and preparation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836409A (en) * 2012-09-05 2012-12-26 张梅 Traditional Chinese medicine for treating postpartum lochiorrhea and preparation method
CN103933425A (en) * 2014-04-11 2014-07-23 胡海波 Traditional Chinese medicine composition for treating lung cancer and preparation method thereof
CN104288322A (en) * 2014-10-09 2015-01-21 四川金堂海纳生物医药技术研究所 Oral medicament for treating rosacea and preparation method

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