CN105395948A - traditional Chinese medicine additive for eel and preparation method thereof - Google Patents

traditional Chinese medicine additive for eel and preparation method thereof Download PDF

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Publication number
CN105395948A
CN105395948A CN201510946914.1A CN201510946914A CN105395948A CN 105395948 A CN105395948 A CN 105395948A CN 201510946914 A CN201510946914 A CN 201510946914A CN 105395948 A CN105395948 A CN 105395948A
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herba
chinese medicine
medicine additive
radix
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郝智慧
王仕文
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郝智慧
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/14Cupressaceae (Cypress family), e.g. juniper or cypress
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
    • Y02A40/81Aquaculture, e.g. of fish
    • Y02A40/818Alternative feeds for fish, e.g. in aquacultures

Abstract

The invention discloses a traditional Chinese medicine additive for eel and a preparation method thereof. The traditional Chinese medicine additive comprises the following bulk drugs: fineleaf schizonepeta herb, herba taraxaci, common scouring rush herb, radix scutellariae, heartleaf houttuymia herb, herba andrographis, lasiosphaera seu calvatia, cortex moutan, sweet wormwood herb, cortex lycii, humifuse euphorbia herb, radix tinosporae, common cephalanoplos herb, fructus gardeniae, cacumen platycladi, hairyvein agrimonia herband bud, radix boehmeriae, rhizoma imperatae, rhizoma phragmitis, radix rubiae, creeping rostellularia herb, herb of narrowleaf falsepimperned, semen torreyae and herb of common maidenhair spleenwort. The beneficial effects comprise that the traditional Chinese medicine additive employs the main treatment principle of clearing heat and detoxifying, cooling blood and stopping bleeding, takes traditional Chinese medicine theory as the basis, considers the whole body, combines prevention and treatment, effectively removes disease pathogen, and realizes good clinic treatment effect. The traditional Chinese medicine additive is capable of curing eel hemorrhagic open-mouth disease and improving body disease-pathogen defending resisting capabilities, and also is capable of improving the production performance of eel. Extremely good health-care effect is given play on consumers frequently eating the eel, and economic benefit of culturists is improved.

Description

A kind of Anguillar japonica Chinese medicine additive and preparation method thereof
This case is divisional application, and the denomination of invention of original application is: a kind of eel compound feed and preparation method thereof, and the applying date of original application is: 2014-07-11, and the application number of original application is: 201410327620.6.
Technical field
The present invention relates to the animal cultivation Chinese medicine additive containing deriving from plant, animal or raw mineral materials, particularly a kind of Anguillar japonica Chinese medicine additive and preparation method thereof.
Background technology
Anguillar japonica is that property straddling fish stocks in river fall in one, originates in marine, grows up in river to fresh water of tracing back, after get back to marine laying eggs.In annual spring, large quantities of elver (also claiming white young, eel line) enters rivers mouth from sea in groups.It is traditional famous and precious Fish, is also one of the most mysterious in the world Fish.Its growth course is very peculiar, seedling of laying eggs in the seawater before this, after enter again fresh water grow up.Anguillar japonica still can survive after a year and a half " going on a hunger strike ", and the Anguillar japonica life-span of cultivation is 50 years.
The cause of disease of Anguillar japonica Hemorrhagic open-mouth disease is a kind of DNA (deoxyribonucleic acid) type virus.Anguillar japonica Hemorrhagic open-mouth disease has Case report in China Fujian, Guangdong.Anguillar japonica more than main harm 1 full age.5 ~ October is morbidity season, and onset peak is 7 ~ August, and mortality rate can reach 90%.
Ill Anguillar japonica shows as severe haemorrhage, and mainly cranial cavity is hemorrhage, is secondly that oral cavity and muscle of head are hemorrhage.Sick fish osteoporosis, easily osteomiosis occurring, there is blank in cranial cavity; Junction between dentary and ossa articularia gets loose, and oral cavity is often opened, and can not close.Liver,spleen,kidney enlargement, extremely anemia.Ultrathin section observation is carried out to sick eel blood, can virion be seen in hemocyte.
Histopathologic change: liver,kidney,spleen is dirty to be organized in hemorrhage, cytopathy, sclerotin has the pathological change of a large amount of leukocyte infiltration, liver,kidney,spleen dirty cell ultrastructure obvious, there is nuclear chromatin limit collection, unusual forming core, a large amount of myelin figure in kidney, spleen hemopoietic tissue and peripheral blood cells, autophagosome and autophagy lysosome etc., and in visible similar apoptotic cell and apoptotic body structure and adjacent cells, phagosome increases phenomenon.
Western medical treatment Anguillar japonica Hemorrhagic open-mouth disease there is no effectively preventing method at present, and mainly on the basis of comprehensive prevention, full pond float bactericide, in case bacteriological infection and increase the weight of the state of an illness.A large amount of ill Anguillar japonica brings huge economic loss to culturist, a kind of medicine effectively can treating Anguillar japonica Hemorrhagic open-mouth disease of market in urgent need, or feedstuff is to meet the demand in market, effectively control Anguillar japonica Hemorrhagic open-mouth disease, at utmost reduces risk and the economic loss of eel culture.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of eel compound feed, this feedstuff comprises the Chinese medicine additive with heat-clearing and toxic substances removing, cooling blood for hemostasis effect, can prevent and treat Anguillar japonica Hemorrhagic open-mouth disease, adopt natural Chinese medicines material, toxic and side effects is low, drug residue free, not only can disease therapy, the disease-resistant evil ability of defence of body can also be improved, after consumer eats this type of Anguillar japonica, can also immunity of organisms be improved, play good health-care effect, improve the economic benefit of culturist.
In order to realize foregoing invention object, the invention provides a kind of eel compound feed, described feedstuff comprises that puffing Semen sojae atricolor, Semen Tritici aestivi, dried silkworm chrysalis, Lumbricus are dry, spray-dried plasma protein, bone meal, nanometer Montmorillonitum, propolis, Semen Maydis oil, choline chloride, vitamin premix, microelement pre-mix material, compound enzymic preparation and Chinese medicine additive.
In described feedstuff, the parts by weight of each raw material are: puffing Semen sojae atricolor 15-21 weight portion, Semen Tritici aestivi 16-25 weight portion, dried silkworm chrysalis 21-29 weight portion, Lumbricus does 24-29 weight portion, spray-dried plasma protein 3-7 weight portion, bone meal 5-8 weight portion, nanometer Montmorillonitum 2-6 weight portion, propolis 5-10 weight portion, Semen Maydis oil 1-4 weight portion, choline chloride 0.3-1.5 weight portion, vitamin premix 0.05-0.1 weight portion, microelement pre-mix material 0.05-0.12 weight portion, compound enzymic preparation 1-3 weight portion and Chinese medicine additive 2-5 weight portion.
In described feedstuff, the parts by weight of each raw material are preferably: puffing Semen sojae atricolor 17 weight portion, Semen Tritici aestivi 21 weight portion, dried silkworm chrysalis 26 weight portion, Lumbricus dry 27 weight portions, spray-dried plasma protein 5 weight portion, bone meal 6 weight portion, nanometer Montmorillonitum 4 weight portion, propolis 7 weight portion, Semen Maydis oil 2 weight portion, choline chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, compound enzymic preparation 2 weight portion and Chinese medicine additive 3 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: Herba Schizonepetae, Herba Taraxaci, Herba Equiseti Hiemalis, Radix Scutellariae, Herba Houttuyniae, Herba Andrographis, Lasiosphaera Seu Calvatia, Cortex Moutan, Herba Artemisiae Annuae, Cortex Lycii, Herba Euphorbiae Humifusae, Radix Tinosporae, Herba Cirsii, Fructus Gardeniae, Cacumen Platycladi, Herba Agrimoniae, Radix Boehmeriae, Rhizoma Imperatae, Rhizoma Phragmitis, Radix Rubiae, Herba Rostellulariae, Lindernia angustifolia (Benth.) Wettst., Semen Torreyae and phoenix tail ferrum hornwart.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Schizonepetae 10-20 weight portion, Herba Taraxaci 15-25 weight portion, Herba Equiseti Hiemalis 10-20 weight portion, Radix Scutellariae 12-17 weight portion, Herba Houttuyniae 17-25 weight portion, Herba Andrographis 10-17 weight portion, Lasiosphaera Seu Calvatia 10-14 weight portion, Cortex Moutan 14-20 weight portion, Herba Artemisiae Annuae 10-15 weight portion, Cortex Lycii 14-20 weight portion, Herba Euphorbiae Humifusae 10-16 weight portion, Radix Tinosporae 13-19 weight portion, Herba Cirsii 12-17 weight portion, Fructus Gardeniae 10-15 weight portion, Cacumen Platycladi 15-20 weight portion, Herba Agrimoniae 10-15 weight portion, Radix Boehmeriae 15-22 weight portion, Rhizoma Imperatae 13-17 weight portion, Rhizoma Phragmitis 15-20 weight portion, Radix Rubiae 10-16 weight portion, Herba Rostellulariae 13-20 weight portion, Lindernia angustifolia (Benth.) Wettst. 12-24 weight portion, Semen Torreyae 14-20 weight portion and phoenix tail ferrum hornwart 15-20 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: Herba Schizonepetae 15 weight portion, Herba Taraxaci 19 weight portion, Herba Equiseti Hiemalis 15 weight portion, Radix Scutellariae 15 weight portion, Herba Houttuyniae 20 weight portion, Herba Andrographis 14 weight portion, Lasiosphaera Seu Calvatia 12 weight portion, Cortex Moutan 17 weight portion, Herba Artemisiae Annuae 12 weight portion, Cortex Lycii 17 weight portion, Herba Euphorbiae Humifusae 13 weight portion, Radix Tinosporae 17 weight portion, Herba Cirsii 14 weight portion, Fructus Gardeniae 12 weight portion, Cacumen Platycladi 18 weight portion, Herba Agrimoniae 12 weight portion, Radix Boehmeriae 18 weight portion, Rhizoma Imperatae 15 weight portion, Rhizoma Phragmitis 17 weight portion, Radix Rubiae 13 weight portion, Herba Rostellulariae 17 weight portion, Lindernia angustifolia (Benth.) Wettst. 17 weight portion, Semen Torreyae 18 weight portion and phoenix tail ferrum hornwart 18 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
Wherein, described compound enzymic preparation comprises one or more in amylase, protease, cellulase, 1,4 beta-glucanase, pectase and phytase.
In order to better realize foregoing invention object, present invention also offers a kind of preparation method of eel compound feed, described preparation method comprises the following steps:
Pulverising step: take that puffing Semen sojae atricolor, Semen Tritici aestivi, dried silkworm chrysalis, Lumbricus are dry, bone meal, nanometer Montmorillonitum and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after spray-dried plasma protein, Semen Maydis oil, choline chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixing, more fully mix with the comminuting matter obtained in pulverising step;
Micronizing step: drop into pulverizer and carry out micronizing;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight compound enzymic preparation being sprayed to pellet.
Present invention also offers a kind of eel compound feed Chinese medicine additive, described Chinese medicine additive has following raw medicinal material to make: Herba Schizonepetae 10-20 weight portion, Herba Taraxaci 15-25 weight portion, Herba Equiseti Hiemalis 10-20 weight portion, Radix Scutellariae 12-17 weight portion, Herba Houttuyniae 17-25 weight portion, Herba Andrographis 10-17 weight portion, Lasiosphaera Seu Calvatia 10-14 weight portion, Cortex Moutan 14-20 weight portion, Herba Artemisiae Annuae 10-15 weight portion, Cortex Lycii 14-20 weight portion, Herba Euphorbiae Humifusae 10-16 weight portion, Radix Tinosporae 13-19 weight portion, Herba Cirsii 12-17 weight portion, Fructus Gardeniae 10-15 weight portion, Cacumen Platycladi 15-20 weight portion, Herba Agrimoniae 10-15 weight portion, Radix Boehmeriae 15-22 weight portion, Rhizoma Imperatae 13-17 weight portion, Rhizoma Phragmitis 15-20 weight portion, Radix Rubiae 10-16 weight portion, Herba Rostellulariae 13-20 weight portion, Lindernia angustifolia (Benth.) Wettst. 12-24 weight portion, Semen Torreyae 14-20 weight portion and phoenix tail ferrum hornwart 15-20 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
The invention has the beneficial effects as follows: feedstuff of the present invention contains with heat-clearing and toxic substances removing, cooling blood for hemostasis is the Chinese medicine additive of primary treatment principle, based on theory of Chinese medical science, from entirety, control combines, effective dispeling disease and evil, reach good clinical therapeutic efficacy, Chinese medicine additive adopts natural Chinese medicines material, and toxic and side effects is low, drug residue free; Chinese medicine additive and other raw materials cooperatively interact, not only can treat Anguillar japonica Hemorrhagic open-mouth disease, improve the disease-resistant evil ability of defence of body, the fertility performance of Anguillar japonica can also be improved, good health-care effect plays after eating this type of Anguillar japonica in consumer, improves the economic benefit of culturist.
Detailed description of the invention
Chinese veterinarian's theory is thought when a variety of causes causes venation damage or abnormal circulation of blood, blood from overflowing arteries and veins will be caused outer and form blood disorder.Say as " Sanyin Ji Yi Bingzheng Fang Lun is lost blood and chatted opinion ": " husband's blood still water also, water by ground row, hundred rivers are all managed, then without stop up determine anxiety.The circumfluence of blood in person honor, warp, mansion, Yu, outward not by four gas are hindered, inside not by seven emotions are strongly fragrant, naturally pleasantly.Just in case micro-refreshing joint a surname, must cause heap soil or fertilizer over and around the roots and close, therefore blood must not follow through multiple abscess, flourishly support hundred arteries and veins, or tears or loose, or lower and die anti-, or inverse and overflow, be tell, be defeated in battle, just, all card lifes of profit, antiperspirant, expectorant here." Haemorrhagic Mouth-opening Disease of The Eel, anguilla Japonica mainly intimately smokedly burns, the absurd row of forcing blood and deficient QI failing to control, the outer two class reasons of blood oozing from the body openings or subcuta neous tissue arteries and veins.
Based on above-mentioned Chinese veterinarian's therapy theory, be primary treatment principle in line with heat-clearing and toxic substances removing, cooling blood for hemostasis, the invention provides a kind of feedstuff containing Chinese medicine additive, in feedstuff, add Chinese medicine additive, thus the generation of control Haemorrhagic Mouth-opening Disease of The Eel, anguilla Japonica.Eel compound feed of the present invention comprises that puffing Semen sojae atricolor, Semen Tritici aestivi, dried silkworm chrysalis, Lumbricus are dry, spray-dried plasma protein, bone meal, Semen Maydis oil, choline chloride, vitamin premix, microelement pre-mix material, compound enzymic preparation and Chinese medicine additive; Wherein, Chinese medicine additive comprises following raw medicinal material: Herba Schizonepetae, Herba Taraxaci, Herba Equiseti Hiemalis, Radix Scutellariae, Herba Houttuyniae, Herba Andrographis, Lasiosphaera Seu Calvatia, Cortex Moutan, Herba Artemisiae Annuae, Cortex Lycii, Herba Euphorbiae Humifusae, Radix Tinosporae, Herba Cirsii, Fructus Gardeniae, Cacumen Platycladi, Herba Agrimoniae, Radix Boehmeriae, Rhizoma Imperatae, Rhizoma Phragmitis, Radix Rubiae, Herba Rostellulariae, Lindernia angustifolia (Benth.) Wettst., Semen Torreyae and phoenix tail ferrum hornwart.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.Heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decoct control violent trauma tremble with fear." " detailed outline ": " throat, the skin ulcer that disappears swells for loose wind heat, refresh oneself.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Make fever in rabbits with typhoid fever polyvalent vaccine, give Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Herba Schizonepetae oil can reduce normal rat body temperature; Also have sedation, Herba Schizonepetae oil (0.5ml/kg) is to rabbit gavage, and its movable minimizing as seen, limb muscle is slightly lax.Herba Schizonepetae oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to Cavia porcellus, reduces the number of animals occurring to twitch; The guinea pig tracheal smooth muscle that also can cause anti-acetylcholine or histamine is shunk; Still there is phlegm-dispelling functions.
Herba Taraxaci: the effect with resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus in vitro, also has certain bactericidal action to Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis.Herba Taraxaci extract (1:400) can suppress tulase in vitro.Herba Taraxaci water decoction (1:80) can delay ECHO11 viral cytopathic.Taraxol extract 31mg/kg can kill leptospira.Water logging agent has inhibitory action to various skin fungus.Decoct, to Oral Administration in Rats, absorbs good, can keep certain antibacterial action in urine.Also have protect the liver, the effect of function of gallbladder promoting, by Herba Taraxaci decoct gavage or with Dandelion Injectable Solution injection, the glutamate pyruvate transaminase caused carbon tetrachloride raises obvious inhibitory action; Significantly can alleviate the Histological change that carbon tetrachloride hepatic injury causes.Have report to point out, Herba Taraxaci has choleretic effect in animals.Herba Taraxaci liquid gavage can make gallbladder contraction, and oddi's sphincter relaxes, and is conducive to bile and enters in intestinal.Clinically to chronic gallbladder spasmolytic and calculosis effective.Also there is immunologic function, Herba Taraxaci decoct can significantly improve peripheral blood lymphocyte blast transformation rate in vitro, Taraxacum Polysaccharides significantly can strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice callosity delayed hypersensitivity intensity, and have administration time more effective feature more backward, the administration on the 11st ~ 20th namely after antigenic stimulus or 2 ~ 20 the next day administration have obvious effect.Taraxacum Polysaccharides lumbar injection significantly can strengthen the cytotoxicity of mouse antibodies dependency macrophage.
Herba Equiseti Hiemalis: sweet in the mouth, hardship, property is put down; Return lung, Liver Channel.Compendium of Material Medica: " Herba Equiseti Hiemalis, with the Herba Ephedrae similar shape same sex, therefore also can diaphoresis expelling pathogenic factors from muscles, rise loose fire stagnation rheumatism, control all blood disorders of eyes also." " book on Chinese herbal medicine justice ": " diaphoresis, expelling pathogenic factors from muscles.Cure the wound cold, malaria.Curing rheumatism, loose pathogenic fire." Herba Equiseti Hiemalis's ethanol extract 10-15g/kg lumbar injection or 20g/kg duodenal administration, there is lasting hypotensive effect to anesthetized cat.Blood pressure lowering intensity and hold time and have certain dependency with dosage.And can to the effect of antihistamine vasoconstrictive, still have hypotensive effect to the cat of cutting off spinal cord, therefore think the periphery property at its blood pressure lowering position.Obvious dilating effect is had to rabbit myocardium vessel.Have excitation to rabbit intestinal and guinea pig ileum during Herba Equiseti Hiemalis's alcohol extract low concentration, myenteron contraction frequency and muscular tension can be made to increase, and contractive amplitude strengthens, then in inhibitory action during high concentration.Herba Equiseti Hiemalis's injection breathes rabbit and heart in place has no significant effect; Certain inhibitory action is had to the contractility of rabbit isolated heart.
Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri is best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so house Radix Scutellariae can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section half exterior and half interior, agent is also." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae has antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus, there is certain inhibitory action, have good curative effect to upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc.
Herba Houttuyniae: pungent, is slightly cold.Return lung meridian, be used as medicine, the traditional Chinese medical science thinks its acrid in the mouth, cold, energy heat-clearing and toxic substances removing, the detumescence of row's pain treat skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion, with controlling excess-heat, pyretic toxicity, damp, disease heat is the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. suffered from, alone or compatibility compound recipe, the equal determined curative effect of use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, Herba Houttuyniae master is containing volatile oil, and the multiple components such as decanoylacetaldehyde houttuynine sodium bisulfite, have suppression antibacterial action to various Xenorhabdus, coccus, influenza virus, leptospira etc., and can improve human immunity regulatory function.
Herba Andrographis: have heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.Preparation and usage: make injection punishment, oral capsule or tablet, consumption must be looked various places and produce the different content of preparation and different.To general inflammation infection, can the decoction of Herba Andrographis Radix Glycyrrhizae 2 ~ 3 money, every day 1 dose; Or tablet (the suitable crude drug in whole of every sheet 1 gram) takes orally, each 4 ~ 8, every day 3 ~ 4 times.To cutization pyogenic infection wound surface, available Folium Andrographis is ground into powder, makes 1:4 aqueous solution, leaching gauze external application wound.Ear drop topical application be can be made into suppurative otitis media, simultaneously Tabellae Andrographitis for oral administration.
Lasiosphaera Seu Calvatia: pungent, flat, nontoxic.Main be used as local hemostatic, doublely control throat pain, aphonia etc.Traumatic hemorrhage, epistaxis, postextraction hemorrhage: Lasiosphaera Seu Calvatia tears epithelium off, gets inner sponge floss sample thing compressing bleeding part or fills in nostril, filling gingiva place, have good hemostatic function.Carbuncle furuncle: Lasiosphaera Seu Calvatia spore powder, is in harmonious proportion with Mel and applies affected part.Chilblain: first embathed by affected part warm water, makes local rubescent, wipe dry after to apply ointment or plaster Lasiosphaera Seu Calvatia by affected part size.Lasiosphaera fenzlii Reics has to oral cavity hemorrhagic illness usefulness of significantly stopping blooding, not second to starch sponge or gelfoam, also effective to epistaxis.Lasiosphaera fenzlii Reics decoct has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, Bacillus proteus and Diplococcus pneumoniae, also has inhibitory action to minority pathomycete.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer." " Japan hanako materia medica ": " except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Cortex Moutan can increase coronary flow to the anesthetized dog heart, reduces cardiac output, reduces the effect of left room work done.The mice heating that paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Herba Artemisiae Annuae: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Function: clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) falls apart thoroughly, and the kind the moon that makes divides a latent heat thoroughly to reach outer faling apart, and is fever due to yin deficiency key medicine, has expelling summer-heat in addition, cut cruel merit.Arteether extracts neutral fraction and its rare alcohol extractum to Mus malaria, monkey malaria and people's malaria all in remarkable Antimalarial.Decocting liquid has stronger bacteriostasis to staphylococcus epidermidis, micrococcus catarrhalis, anthrax bacillus, diphtheria corynebacterium, also has certain inhibitory action to staphylococcus aureus, bacillus pyocyaneus, dysentery bacterium, tuberculosis stalk bacterium etc.Ether extract, rare alcohol extractum and arteannuin to Mus malaria, monkey malaria, people's malaria all in remarkable Antimalarial.Arteannuin also can decreased heart rate, suppresses myocardial contraction, reduces coronary flow.
Cortex Lycii: cold in nature, sweet in the mouth; Enter lung, liver, kidney channel." not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat." " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternate attacks of chills and fever, allly sees blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine." removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition generates heat, and quench one's thirst, pulmonary cough is breathed heavily, and spits blood, epistaxis, hematuria.Modern times are used for the treatment of hypertension, flat wart, palmoplantar verruca, universal eczema, pulpitis pain etc.
Herba Euphorbiae Humifusae: be the Herba Euphorbiae Humifusae of euphorbia plant, is a kind of Chinese crude drug, gathers at summer, Qiu Erji, and removing impurity, dries." book on Chinese herbal medicine converges and says ": " removing pathogenic heat from blood and dissipating blood stasis, the medicine of removing toxic substances dysentery relieving also.Kind through-flow blood vessels, specially clear up skin infection.All disorders of blood and because of hot institute envoy, suitable with it.If non-heat in blood is disease, and the thin weak person of gastric qi, again when consideration row." Compendium of Material Medica: " main carbuncle malignant boil, it is hemorrhage that Jin Ren flutters damage, dysentery, hematochezia, metrorrhagia, and the blood that can fall apart stops blooding, diuresis." can heat-clearing and toxic substances removing, dampness removing jaundice eliminating, promoting blood circulation and hemostasis.Main dysentery, have loose bowels, jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer etc.Heat in blood spit blood, epistaxis person, can with Radix Rehmanniae, the same use of Cortex Moutan, to increase the merit of cooling blood for hemostasis.Jaundice due to damp-heat, dysuria person, can be alone, or with the compatibility such as Herba Artemisiae Scopariae, Fructus Gardeniae, with heat-clearing and dampness-resolving, also can be used for carbuncle malignant boil, traumatic pain eczema ulcer, burn and scald injure all cards of venom, clinical multiplex fresh goods mashes external application.
Radix Tinosporae: bitter, cold.Return lung, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, sore-throat relieving, pain relieving.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.
Herba Cirsii: sweet, bitter, cold.GUIXIN, Liver Channel." classifying herbal ": " control stranguria with blood distending pain, traumatic injury, redly to collapse, leucorrhea." function cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Obviously can raise the blood pressure of non-reserpinization rat after Herba Cirsii crystallization iv, boosting intensity exists obviously, and obviously weakens the boosting of reserpinization rat Herba Cirsii crystallization, and without dose-effect relationship, the similar cruel amine of this interaction property.Herba Cirsii water decoction 0.075g/ml nutritional solution is to the rabbit aorta strip performance contraction of tool adrenergic a receptor, and this effect can by a receptor blocking agent phentolamine institute antagonism.Herba Cirsii is traditional Hemostatic of traditional herb medicine, has confirmed that it has anastalsis, and obtains the effective ingredient that stops blooding.Herba Cirsii hemostasis mainly through making local vasoconstriction, suppresses fibrinolytic and plays effect.
Fructus Gardeniae: bitter, cold.GUIXIN, lung, tri-jiao channel.Function cures mainly: fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Cacumen Platycladi: " Amplification on Materia Medica addendum ": " how dry its property is for Cacumen Platycladi (Cacumen Biotae), the key medicine of nourishing YIN, of a specified duration it, large strengthening the spleen soil, to grow its lung." " Bencao Jingshu ": " and Cacumen Platycladi, bitter in the mouth and tepor, justice should and in being slightly cold, therefore in vain red in all metrorrhagias of winner.With regard to QI invigorating of making light of one's life by commiting suicide, make us resistance to cold and summer-heat, be then slightly same as the property of cypress reality.Only granulation promoting is dried numbness, be its length of solely arrogating to oneself also." " Mingyi Bielu ": " main haematemesis, epistaxis, dysentery blood, metrorrhagia are in vain red.To make light of one's life by commiting suicide QI invigorating, make us resistance to cold and summer-heat, numbness of drying, granulation promoting." Cacumen Platycladi decoct can obviously shorten bleeding time and clotting time, its hemostasis effective ingredient is Quercetin and tannin.In addition, effects such as still having antitussive, eliminate the phlegm, relieving asthma, be calm.Experiment in vitro shows, these product all have inhibitory action to staphylococcus aureus, micrococcus catarrhalis, dysentery bacterium, Bacillus typhi, diphtheria corynebacterium etc.
Herba Agrimoniae: bitter in the mouth, puckery, property is put down, GUIXIN, Liver Channel, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache in face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.Anaphylaxis: show as uncomfortable in chest, breathe hard, cardiopalmus, agitation, dizziness and blurred vision, dripping sweat, pale complexion, cold limbs, shiver with cold, blood pressure drops.Severe one still has dizziness, flushed face, dripping sweat.Toxic retrobulbar neuritis is blind, abdominal pain diarrhea, vomiting, flushing, blood pressure drops.
Radix Boehmeriae: sweet in the mouth is sliding, cold, nontoxic; Enter lung, spleen channel." Japan hanako materia medica ": " control heart heat of the diaphragm, leak tire hematochezia, antenatal rear vexed vexed, the capable hot disease in sky, extreme thirst large Kuang , An poisoned arrow, snakeworm are stung." essentials of Matea Medica: " and nourishing YIN, removing blood stasis with potent drugs, antipyretic, moisturize.Control carbuncle, carbuncle on the back, incised wound, injured, chicken, fishbone are choked." function heat clearing away, hemostasis, removing toxic substances, dissipating blood stasis.Control calentura extreme thirst, mad greatly, stranguria with blood, the difficulty in urination, spit blood, hematochezia, leucorrhea with red and white discharge, erysipelas, carbuncle, traumatic injury, snake bite and insect sting.The extract of Herba Boehmeriae siamensis soaks the artificial Boehmeria sheet wound surface of rat and mouse tail end, can use oligemia, and the bleeding time shortens. to Mouse oral or lumbar injection, also there is effect same.Acylate contained by Radix Boehmeriae and alkaloid all have inhibitory action to gram positive bacteria and negative bacterium in vitro.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel." Bencao Tujing ": " Rhizoma Imperatae, the present has it everywhere.Spring sprouts, and cloth ground is as pin, and the thatch pin called between custom, also can eat, very beneficial children's.Xia Sheng spends in vain, so fine, withered to the autumn, and its root, to pure white, also very sweet and refreshing, adopted root June and used." Compendium of Material Medica: " emesis is defeated in battle all blood, typhoid fever hiccup, lung-heat dyspnea with rapid respiration, edema, jaundice, alcoholic intoxication." have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, be mainly used in haematemesis, hemoptysis that lung stomach has accumulated heat, damp invasion of lower energizer pents up the hematuria of bladder, calentura excessive thirst taking fluids profusely, gastropyretic vomiting, the cards such as jaundice due to damp-heat.Rhizoma Imperatae decoct and water logging agent gavage, and have diuresis to normal rabbits, administration 5-10 days, and diuresis is the most obvious.Rhizoma Imperatae decoct has obvious inhibitory action to Fu Shi and sonne bacillus in vitro, but to will Hayes and the effect of easypro Shigella flexneri nothing.Coixol contained by Rhizoma Imperatae has inhibitory action to the contraction of skeletal muscle and metabolism.
Rhizoma Phragmitis: sweet, cold; Return lung meridian, stomach warp." property of medicine opinion ": " large heat can be separated, appetizing.Control the sound of vomiting of choking more than." " Japan hanako materia medica ": " when controlling cold and heat, disease is unhappy, good pregnant people's heat in the heart, and dysentery people is thirsty." clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis is used for gastropyretic vomiting.Rhizoma Phragmitis can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again greasyly to hinder stomach, therefore to vomit the key medicine of the sound of vomiting for controlling gastric heat.The lighter is alone, and severe one often joins Caulis Bambusae In Taenia, Rhizoma Zingiberis Recens, Semen oryzae sativae etc., to strengthen heat clearing away sending down the abnormal ascending QI, and the merit of middle preventing or arresting vomiting, side is as Thousand Golden Prescriptions Rhizomatis Phragmitis Potion.The contractile response caused by electricity irritation of frog neuromuscular specimen and the oxygen of diaphragm in rats can be suppressed to absorb and anaerobic glycolysis, have relexation to isolated guinea pig intestinal tube.
Radix Rubiae: cold in nature, bitter in the mouth, returns Liver Channel, " Bencao Jingshu ": " rubia, the key medicine of promoting the circulation of blood removing heat from blood.Main numbness and subcutaneous ulcer.Subcutaneous ulcer has five, this its for controlling, lid does not refer to jaundice due to accumulation of stagnant blood, and not specially in damp and hot person yet.Numbness person's disorders of blood, promoting the circulation of blood softening the hard mass.Then numbness spontaneous recovery." " Japan hanako materia medica ": " and only serious epistaxis, leukorrhagia, puerperal blood faints, breast knot, menstruation is more than, hemorrhoidal hamorrhage hemorrhoid complicated by anal fistula, evacuation of pus; Control furuncle, let out essence, hematuria, flutter damage blood stasis." effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cards such as curing mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.The antitussive action of Radix Rubiae is comparatively strong, eliminates the phlegm, relievings asthma and take second place, and have certain antiinflammation; After taking medicine, dry, the moist rale of pulmonary and wheezing sound majority reduce or disappear.
Herba Rostellulariae: micro-hardship, cold.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain, infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria; External is controlled carbuncle furuncle and is swollen, traumatic injury.
Lindernia angustifolia (Benth.) Wettst.: property is put down, acrid in the mouth is bitter.Function cures mainly: the diarrhea of heat type that disappears wets, stomach function regulating, blood stasis removing.To harness the Yellow River subcutaneous ulcer, dysentery, acute gastroenteritis, acute laryngitis, tonsillitis, traumatic injury.
Semen Torreyae: sweet is flat.Return lung, stomach, large intestine channel.Function cures mainly: killing insect and eliminating accumulation, moistening dryness for relaxing bowels.For ancylostome, ascarid, taeniasis, abdominal pain due to worm stagnation, infantile malnutrition, constipation.
Phoenix tail ferrum hornwart: light, cool.Function cures mainly: heat-clearing and toxic substances removing, regulating menstruation, hemostasis, convergence leukorrhagia stopping.For infantile hyperpyrexia, leucorrhea, menoxenia; Burn and scald is controlled in external, traumatic hemorrhage, furuncle swelling toxin, venom.
Wherein, in feedstuff, propolis seals the natural gum gathered from plant petal and trunk, be mixed into a kind of colloidal solid material with aromatic odor that its material such as mandibular gland secretions and Cera Flava is formed, it is rich in abundant trace element, enzyme, Oleum sesami essence and a large amount of flavone compound, strengthens digesting and assimilating and anabolism in vivo of nutrient substance, promote intestinal movement, regulating intestinal canal growth of microorganism, promotes cellular immunization and humoral immune function, health invigorating and anti-stress ability; Nanometer Montmorillonitum directly to adsorb on the one hand mycotoxin wherein, pathogenic bacteria, virus, toxic metabolic products and virulence factor after entering young anguilla japonica gastrointestinal tract; can also be combined with intestinal mucosa mucus glycoprotein on the other hand and form protecting film, preferentially can be adsorbed by nanometer Montmorillonitum when virulence factor attacks intestinal mucosa and protect intestinal mucosa benefit to award damage.
Wherein, in described feedstuff, the parts by weight of each raw material are: puffing Semen sojae atricolor 15-21 weight portion, Semen Tritici aestivi 16-25 weight portion, dried silkworm chrysalis 21-29 weight portion, Lumbricus do 24-29 weight portion, spray-dried plasma protein 3-7 weight portion, bone meal 5-8 weight portion, nanometer Montmorillonitum 2-6 weight portion, propolis 5-10 weight portion, Semen Maydis oil 1-4 weight portion, choline chloride 0.3-1.5 weight portion, vitamin premix 0.05-0.1 weight portion, microelement pre-mix material 0.05-0.12 weight portion, compound enzymic preparation 1-3 weight portion and Chinese medicine additive 2-5 weight portion.
In described feedstuff, the parts by weight of each raw material are preferably: puffing Semen sojae atricolor 17 weight portion, Semen Tritici aestivi 21 weight portion, dried silkworm chrysalis 26 weight portion, Lumbricus dry 27 weight portions, spray-dried plasma protein 5 weight portion, bone meal 6 weight portion, nanometer Montmorillonitum 4 weight portion, propolis 7 weight portion, Semen Maydis oil 2 weight portion, choline chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, compound enzymic preparation 2 weight portion and Chinese medicine additive 3 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: Herba Schizonepetae, Herba Taraxaci, Herba Equiseti Hiemalis, Radix Scutellariae, Herba Houttuyniae, Herba Andrographis, Lasiosphaera Seu Calvatia, Cortex Moutan, Herba Artemisiae Annuae, Cortex Lycii, Herba Euphorbiae Humifusae, Radix Tinosporae, Herba Cirsii, Fructus Gardeniae, Cacumen Platycladi, Herba Agrimoniae, Radix Boehmeriae, Rhizoma Imperatae, Rhizoma Phragmitis, Radix Rubiae, Herba Rostellulariae, Lindernia angustifolia (Benth.) Wettst., Semen Torreyae and phoenix tail ferrum hornwart.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Schizonepetae 10-20 weight portion, Herba Taraxaci 15-25 weight portion, Herba Equiseti Hiemalis 10-20 weight portion, Radix Scutellariae 12-17 weight portion, Herba Houttuyniae 17-25 weight portion, Herba Andrographis 10-17 weight portion, Lasiosphaera Seu Calvatia 10-14 weight portion, Cortex Moutan 14-20 weight portion, Herba Artemisiae Annuae 10-15 weight portion, Cortex Lycii 14-20 weight portion, Herba Euphorbiae Humifusae 10-16 weight portion, Radix Tinosporae 13-19 weight portion, Herba Cirsii 12-17 weight portion, Fructus Gardeniae 10-15 weight portion, Cacumen Platycladi 15-20 weight portion, Herba Agrimoniae 10-15 weight portion, Radix Boehmeriae 15-22 weight portion, Rhizoma Imperatae 13-17 weight portion, Rhizoma Phragmitis 15-20 weight portion, Radix Rubiae 10-16 weight portion, Herba Rostellulariae 13-20 weight portion, Lindernia angustifolia (Benth.) Wettst. 12-24 weight portion, Semen Torreyae 14-20 weight portion and phoenix tail ferrum hornwart 15-20 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: Herba Schizonepetae 15 weight portion, Herba Taraxaci 19 weight portion, Herba Equiseti Hiemalis 15 weight portion, Radix Scutellariae 15 weight portion, Herba Houttuyniae 20 weight portion, Herba Andrographis 14 weight portion, Lasiosphaera Seu Calvatia 12 weight portion, Cortex Moutan 17 weight portion, Herba Artemisiae Annuae 12 weight portion, Cortex Lycii 17 weight portion, Herba Euphorbiae Humifusae 13 weight portion, Radix Tinosporae 17 weight portion, Herba Cirsii 14 weight portion, Fructus Gardeniae 12 weight portion, Cacumen Platycladi 18 weight portion, Herba Agrimoniae 12 weight portion, Radix Boehmeriae 18 weight portion, Rhizoma Imperatae 15 weight portion, Rhizoma Phragmitis 17 weight portion, Radix Rubiae 13 weight portion, Herba Rostellulariae 17 weight portion, Lindernia angustifolia (Benth.) Wettst. 17 weight portion, Semen Torreyae 18 weight portion and phoenix tail ferrum hornwart 18 weight portion.
Wherein, the preparation method of Chinese medicine additive comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
Wherein, described compound enzymic preparation comprises one or more in amylase, protease, cellulase, 1,4 beta-glucanase, pectase and phytase.
The preparation method of feedstuff comprises the following steps:
Pulverising step: take that puffing Semen sojae atricolor, Semen Tritici aestivi, dried silkworm chrysalis, Lumbricus are dry, bone meal, nanometer Montmorillonitum and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after spray-dried plasma protein, Semen Maydis oil, choline chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixing, more fully mix with the comminuting matter obtained in pulverising step;
Micronizing step: drop into pulverizer and carry out micronizing;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight compound enzymic preparation being sprayed to pellet.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Embodiments provide a kind of feedstuff Chinese medicine additive being used for the treatment of Anguillar japonica Hemorrhagic open-mouth disease, the parts by weight of its each raw medicinal material are: Herba Schizonepetae 15 weight portion, Herba Taraxaci 19 weight portion, Herba Equiseti Hiemalis 15 weight portion, Radix Scutellariae 15 weight portion, Herba Houttuyniae 20 weight portion, Herba Andrographis 14 weight portion, Lasiosphaera Seu Calvatia 12 weight portion, Cortex Moutan 17 weight portion, Herba Artemisiae Annuae 12 weight portion, Cortex Lycii 17 weight portion, Herba Euphorbiae Humifusae 13 weight portion, Radix Tinosporae 17 weight portion, Herba Cirsii 14 weight portion, Fructus Gardeniae 12 weight portion, Cacumen Platycladi 18 weight portion, Herba Agrimoniae 12 weight portion, Radix Boehmeriae 18 weight portion, Rhizoma Imperatae 15 weight portion, Rhizoma Phragmitis 17 weight portion, Radix Rubiae 13 weight portion, Herba Rostellulariae 17 weight portion, Lindernia angustifolia (Benth.) Wettst. 17 weight portion, Semen Torreyae 18 weight portion and phoenix tail ferrum hornwart 18 weight portion.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders, obtain Chinese medicine additive powder.
Embodiment 2 feedstuff
Embodiments provide a kind of eel compound feed that can be used in preventing and treating Anguillar japonica Hemorrhagic open-mouth disease, in feedstuff, the parts by weight of each raw material are: puffing Semen sojae atricolor 17 weight portion, Semen Tritici aestivi 21 weight portion, dried silkworm chrysalis 26 weight portion, Lumbricus dry 27 weight portions, spray-dried plasma protein 5 weight portion, bone meal 6 weight portion, nanometer Montmorillonitum 4 weight portion, propolis 7 weight portion, Semen Maydis oil 2 weight portion, choline chloride 0.5 weight portion, vitamin premix 0.08 weight portion, microelement pre-mix material 0.08 weight portion, compound enzymic preparation 2 weight portion and Chinese medicine additive 3 weight portion.
Wherein, Chinese medicine additive is the Chinese medicine additive powder in embodiment 1; Compound enzymic preparation comprises amylase, protease, cellulase, 1,4 beta-glucanase and pectase.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of eel compound feed, described preparation method comprises the following steps:
Pulverising step: take that puffing Semen sojae atricolor, Semen Tritici aestivi, dried silkworm chrysalis, Lumbricus are dry, bone meal, nanometer Montmorillonitum and propolis by weight percentage, drops into pulverizer and pulverizes;
Blend step: by weight percentage by after spray-dried plasma protein, Semen Maydis oil, choline chloride, vitamin premix, microelement pre-mix material and Chinese medicine additive premixing, more fully mix with the comminuting matter obtained in pulverising step;
Micronizing step: drop into pulverizer and carry out micronizing;
Granulation step: drop into granulator, granulates, makes its gelatinization degree reach 90% at 70-80 DEG C;
Spraying process: the surface by weight compound enzymic preparation being sprayed to pellet.
Chinese herbal medicine is the product of the distinctive Chinese medical theory of China and practice, its aboundresources, with a long history.Chinese herbal medicine immunity substance mass-energy improve human body immune function, anti-stress, disease-resistant, improve breeding performonce fo animals, and there is the advantages such as noresidue, not easily generation drug resistance, simultaneously also containing multiple nutritional components and bioactive substance, have the dual function of medicine and nutrition concurrently.For many years, generally believe that Chinese medicine has the advantage of low toxicity, in order to verify safety and the antibiotic property of Chinese medicine additive of the present invention further, spy carries out following experiment.
Toxicity test
1, material prepares
1.1 animals: Kun Ming mice, are provided by Shandong University's Experimental Animal Center, SPF level, male and female dual-purpose, body weight 18-22g.By sex sub-cage rearing, dailyly to feed, freely drink water, room temperature 20-25 DEG C, relative humidity 45%-54%.
1.2 medicines: the Chinese medicine additive powder of the embodiment of the present invention 1, use distilled water wiring solution-forming during use.
1.3 strains: Salmonella, dust Xi Shi escherichia coli, staphylococcus aureus are reference culture.
2, method
2.1 preliminary experiments: mice 18, male and female half and half, are divided into 3 groups at random, and often organize 6, after fasting 12h, gavage gives 31.25%, 62.5%, 125% Chinese medicine additive 0.4ml/10g respectively, 3 times/d, interval 6h, and result is without dead mouse, and prompting cannot measure LD 50, therefore measure mice maximum dosage-feeding on the 1st.
2.2 formal tests: separately get mice 40, male and female half and half, be divided into matched group and experimental group at random by body weight, sex, after fasting 12h, experimental group gavage 125%(Cmax) Chinese medicine additive 0.4ml/10g, 3 times/d, interval 6h.Matched group gives normal saline with method.Observe and record the situations such as mouse diet, outward appearance, behavior, body weight change, death.
3 results: one factor analysis of variance is carried out to the change of duration of test Mouse Weight with SPSS13.0 statistical software.Toxicity test result shows: experimental group and control group mice body weight increase overall all without significant difference.Period mouse hair gloss, activity freely, feed and excretion normal, find no other toxic reactions.In 14d, Mouse Weight is increased to (30.6 ± 1.1) g by (20.0 ± 1.1) g before testing, and does not occur death.During off-test, cervical dislocation puts to death mice, dissects perusal main organs color and morphological change, the main organs no abnormality seens such as the result heart, liver, spleen, lung, kidney.Accordingly, Chinese medicine additive, through mouse stomach administration maximum pharmaceutical quantities 150g/kg on the 1st, has no overt toxicity reaction.
Contrast test
In July, 2011, certain eel culture field finds that the phenomenon that cranial cavity is hemorrhage appears in part Anguillar japonica, and oral cavity is often opened, and can not close.Choose the comparatively serious ill Anguillar japonica of the state of an illness 5, carry out dissection analysis of cases, find liver,spleen,kidney enlargement, and extreme anemia, ultrathin section observation is carried out to blood, can virion be seen in hemocyte.Be diagnosed as Hemorrhagic open-mouth disease.
Random choose 500 ill Anguillar japonicas are as experimental subject, and the situation that the hemorrhage and oral cavity of cranial cavity in various degree can not close all has appearred in 500 Anguillar japonicas.Be divided into two groups at random, be respectively embodiment group and matched group, often organize 250, be put in different fishponds respectively and feed.Embodiment group uses the forage feed of the embodiment of the present invention 2, does not carry out other process; Matched group uses traditional eel feed to feed, and full pond float bactericide (sulfadiazine).Test is 40 days, and period record fish change of illness state only and death toll, result is as shown in table 1.Wherein, in process of the test, Anguillar japonica transference cure, body condition recovers normal completely, is recorded as recovery from illness; Anguillar japonica symptom takes a turn for the better to some extent, the transference cure that the hemorrhage and oral cavity of cranial cavity can not close, and body condition recovers normal substantially; Invalid: exacerbation of symptoms or death.
Table 1 two experimental group fishes change of illness state synopsis bar
Group Sum Recovery from illness Effectively Invalid Effective percentage
Embodiment group 250 46 79 132 50.0%
Matched group 250 8 23 219 12.4%
According to the data of table 1, use feedstuff of the present invention to contain Chinese medicine additive, can be used in treatment Anguillar japonica Hemorrhagic open-mouth disease, with traditional therapy first than, there is the advantages such as therapeutic effect is good, effective percentage is high, have no side effect.
In a word, the present invention contains with heat-clearing and toxic substances removing, cooling blood for hemostasis is the feedstuff of the Chinese medicine additive of primary treatment principle, not only can treat Anguillar japonica Hemorrhagic open-mouth disease, improve the disease-resistant evil ability of defence of body, can also improve the fertility performance of Anguillar japonica, good health-care effect plays after eating this type of Anguillar japonica in consumer, improves the economic benefit of culturist.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (4)

1. an Anguillar japonica Chinese medicine additive, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: Herba Schizonepetae, Herba Taraxaci, Herba Equiseti Hiemalis, Radix Scutellariae, Herba Houttuyniae, Herba Andrographis, Lasiosphaera Seu Calvatia, Cortex Moutan, Herba Artemisiae Annuae, Cortex Lycii, Herba Euphorbiae Humifusae, Radix Tinosporae, Herba Cirsii, Fructus Gardeniae, Cacumen Platycladi, Herba Agrimoniae, Radix Boehmeriae, Rhizoma Imperatae, Rhizoma Phragmitis, Radix Rubiae, Herba Rostellulariae, Lindernia angustifolia (Benth.) Wettst., Semen Torreyae and phoenix tail ferrum hornwart.
2. Anguillar japonica Chinese medicine additive according to claim 1, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Herba Schizonepetae 10-20 weight portion, Herba Taraxaci 15-25 weight portion, Herba Equiseti Hiemalis 10-20 weight portion, Radix Scutellariae 12-17 weight portion, Herba Houttuyniae 17-25 weight portion, Herba Andrographis 10-17 weight portion, Lasiosphaera Seu Calvatia 10-14 weight portion, Cortex Moutan 14-20 weight portion, Herba Artemisiae Annuae 10-15 weight portion, Cortex Lycii 14-20 weight portion, Herba Euphorbiae Humifusae 10-16 weight portion, Radix Tinosporae 13-19 weight portion, Herba Cirsii 12-17 weight portion, Fructus Gardeniae 10-15 weight portion, Cacumen Platycladi 15-20 weight portion, Herba Agrimoniae 10-15 weight portion, Radix Boehmeriae 15-22 weight portion, Rhizoma Imperatae 13-17 weight portion, Rhizoma Phragmitis 15-20 weight portion, Radix Rubiae 10-16 weight portion, Herba Rostellulariae 13-20 weight portion, Lindernia angustifolia (Benth.) Wettst. 12-24 weight portion, Semen Torreyae 14-20 weight portion and phoenix tail ferrum hornwart 15-20 weight portion.
3. Anguillar japonica Chinese medicine additive according to claim 1 and 2, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: Herba Schizonepetae 15 weight portion, Herba Taraxaci 19 weight portion, Herba Equiseti Hiemalis 15 weight portion, Radix Scutellariae 15 weight portion, Herba Houttuyniae 20 weight portion, Herba Andrographis 14 weight portion, Lasiosphaera Seu Calvatia 12 weight portion, Cortex Moutan 17 weight portion, Herba Artemisiae Annuae 12 weight portion, Cortex Lycii 17 weight portion, Herba Euphorbiae Humifusae 13 weight portion, Radix Tinosporae 17 weight portion, Herba Cirsii 14 weight portion, Fructus Gardeniae 12 weight portion, Cacumen Platycladi 18 weight portion, Herba Agrimoniae 12 weight portion, Radix Boehmeriae 18 weight portion, Rhizoma Imperatae 15 weight portion, Rhizoma Phragmitis 17 weight portion, Radix Rubiae 13 weight portion, Herba Rostellulariae 17 weight portion, Lindernia angustifolia (Benth.) Wettst. 17 weight portion, Semen Torreyae 18 weight portion and phoenix tail ferrum hornwart 18 weight portion.
4. the preparation method of the Anguillar japonica Chinese medicine additive according to any one of claim 1-3, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders, obtain Chinese medicine additive powder.
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CN106879875A (en) * 2016-12-31 2017-06-23 新昌县田野泉养殖技术开发有限公司 Eel feed containing Chinese medicine additive and preparation method thereof
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