CN104547794A - Traditional Chinese medicine composition for treating bone fracture - Google Patents
Traditional Chinese medicine composition for treating bone fracture Download PDFInfo
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- CN104547794A CN104547794A CN201510078103.4A CN201510078103A CN104547794A CN 104547794 A CN104547794 A CN 104547794A CN 201510078103 A CN201510078103 A CN 201510078103A CN 104547794 A CN104547794 A CN 104547794A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a bone fracture. The composition is prepared from the following 23 traditional Chinese medicines: tinospora sinensis merr, heterosmilax japonica, smalt, pegia sarmentosa, flemingia philippinensis, gynostemma pentaphylla, aituoduo (Chinese character), herba periliae, asclepiadaceae tylophora koi, sinoadina racemosa, herba chloranthi serrate, clerodendrum serratum var amplexifolium, rhinacanthus nasutus, blumea balsamifera, sambucus chinensis, girardinia diversifolia, red elecampane, ardisia mamillata hance, uncaria rhynchophylla, rhizoma smilacis glabrae, tongking pepper, drynaria total flavonoids and epipremnum pinnatum. The traditional Chinese medicine composition works together to achieve the efficacies of promoting reunion of fractured bones, promoting blood circulation to remove blood stasis, relieving swelling and pain, soothing the channels and activating collaterals, has significant curative effects on treatment of the bone fracture, and can also be applied to soft tissue injuries, ligament and joint strain injuries caused by falling, hitting, touching, knocking and the like; and the symptoms such as local pain, tumidness, dysfunction, black and blue subcutaneous addiction spots or hematoma of patients are removed.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of Chinese medicine composition for the treatment of fracture.
Background technology
Fracture refers to a kind of disease that wound or pathological factor cause bone parts or rupture completely.Along with the development of China's economy, the prosperity of communications and the prosperity of industry and mining, the trend that the sickness rate of fracture is increased significantly, according to statistics, China has nearly 1,200 ten thousand people to fracture because of different reason every year.Can hear bony crepitus when the typical performance of fracture patient is and occurs that abnormal motion, mobile limbs appear in local deformation, limbs etc. after wound, in addition, wound severe pain, there is the dyskinesia etc. after wound in local swelling, congestion, has a strong impact on the life of people.
At present, the bibliographical information of domestic and international associated therapy fracture is a lot of.If application number is the Chinese patent of 200910117418.X, disclose a kind of JIEGU GAO, raw material adopts Chinese Medicinal Material Radix Angelicae Sinensis, Myrrha, Radix Notoginseng, Cornu Bubali, mature vinegar, poplar bud, Cortex ulmi pumilae, Cornu Cervi Pantotrichum, Borneolum Syntheticum, Sanguis Draxonis, Lignum Sappan and forging Bai Rantong, each material medicine is pulverized respectively, porphyrize, sieve, be brewed into the semi-solid externally applied ointment of furvous, what spread onto black cloth class mounts slightly on material, and for sticking in fracture site, this invention has good curative effect to traumatic injury, fracture patient.Application number is the Chinese patent of 201210459648.6, disclose a kind of externally applied ointment for the treatment of fracture, traumatic injury, it is made up of Semen Momordicae, Herba Ephedrae, Radix Notoginseng, the Cortex Eucommiae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Flos Carthami, the Radix Aucklandiae, Radix Angelicae Pubescentis, Fructus Schisandrae Chinensis, Huang Shi, the Radix Paeoniae Alba, Radix Glycyrrhizae, the perfume (or spice) that rubs, Camphora, Plumbum preparatium, Oleum sesami, and this medicine has unique curative effect to fracture, traumatic injury.Although the bibliographical information of associated therapy fracture is many both at home and abroad, achieve certain effect, new higher requirement be it is also proposed to the treatment of fracture and rehabilitation simultaneously: how to shorten the healing time of fracture patient, easy to use, alleviate medical expense, be worth exploring further.The present invention adopts traditional Chinese medicine composition for treating, for inventor practises medicine experience accumulation, constantly perfect achievement for many years, through pharmacology and clinical research, union of fracture can be promoted more fast and effectively, the swelling that alleviating fractures causes, pain, alleviate patient suffering, had not yet to see relevant report.
(1) Herba Lycopodii is the dry stem of menispermaceae plant lobus cardiacus Herba Lycopodii Tinospora cordifolia (wulld) Miers or Herba Lycopodii T.sin-ensis (Lour.) Merr..[nature and flavor with return through] are bitter, puckery, cool.[function with cure mainly] clearing heat and moistening lung, blending pathology is caused disorderly.For liver-heat, visceral heat, pneumonopathy, rheumatic arthritis, ageing diseases.
(2) nine Niu Li are the dry root stock of Smilacaceae plant China Xiao Rhizoma Smilacis Chinensis Heterosmilax chinensis Wang.[nature and flavor] are bitter, pungent, flat.[function with cure mainly] is dispeled the wind, is invigorated blood circulation.For rheumatic lumbago and scelalgia, traumatic injury.
(3) Folium Isatidis is stem, the leaf of Verbenaceae Folium Isatidis Cleredendrum cwtophyllum Turcz..[nature and flavor] are bitter; Cold.[return through] stomach; Heart channel.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main fever caused by exogenous pathogenic factors intenseness of heat excessive thirst; Laryngopharynx swelling and pain; Aphtha; Jaundice; Pyrotoxic dysentery; Acute enteritis; Swollen ulcer drug; Epistaxis; Stranguria with blood; Traumatic hemorrhage.
(4) sharp Caulis Fibraureae is stem, the leaf of Anacardiaceae plant profit Caulis Fibraureae Pegia sarmentosa (Lecte.) Hand.-Mazz..[nature and flavor] acid; Flat.[function cures mainly] clearing away damp-heat; Removing toxic substances.Main jaundice due to damp-heat; Beriberoid pyretic arthralgia; Carbuncle and ulcer; Eczema; Venom.
(5) Radix Flemingiae Philippinensis is leguminous plant Radix Flemingiae Philippinensis Moghania philippinensis (Merr.et Rolfe) Li, Flemingia macrophylla Moghania macrophylla (Willd.) O.Kuntze, root.[nature and flavor] are sweet; Puckery; Flat.[return through] lung; Kidney; Urinary bladder channel.[function cures mainly] expelling wind and removing dampness; Bone and muscle strengthening; Promoting blood circulation and detoxication.Main air pain of dampness syndrome; Lumbar muscle strain; Extremity flaccidity is soft; Traumatic injury; Laryngopharynx swelling and pain.
(6) Herb Gynostemmae Pentaphylli is the dry aerial parts of cucurbitaceous plant Herb Gynostemmae Pentaphylli Gynostemma pentaphyllum (Thunberg) Makino.[nature and flavor with return through] are bitter, micro-sweet, cool.Return lung, spleen, kidney channel.[function with cure mainly] tonify deficiency, heat clearing away, removing toxic substances.Weak for body void, nephrasthenia emission, leukopenia, hyperlipemia, viral hepatitis, chronic gastroenteritis, chronic tracheitis.
(7) short top top, Meliaceae Herba Munroniae henryi platymiscium munronia henryi Harms Munronia henryi Harms, the Herb of Yunnan Herba Munroniae henryi Munronia delavayi Franch..[nature and flavor] pungent, micro-hardship, cool.Slightly poisonous.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping, antipyretic preventing the attack (or recurrence) of malaria.For traumatic injury, rheumatic arthritis, stomachache, flatulence is suffered from abdominal pain, cold, fever, malaria.
(8) Folium Perillae is the dried leaves (or band twig) of labiate Folium Perillae Perilla frutescens (L.) Britt.[nature and flavor with return through] are pungent, temperature.Return lung, spleen channel.[function with cure mainly] induce sweat cold expelling, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.
(9) milk rattan is the Herb of asclepiadaceae plant Herba Dischidiae Chinensis Dichidia tonkinensis Costantin.[nature and flavor] are sweet, micro-hardship, cool in nature.[function cures mainly] removing heat-phlegm, removing pathogenic heat from blood and toxic substance from the body.Control lung-heat hemoptysis, infantile malnutrition, dysentery, furuncle furuncle skin ulcer.
(10) Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. is the Herb of young wooden Adina racemosa (Sieb.Et Zucc.) Miq. of Maguireothamnus speciosus chicken.[nature and flavor] are bitter; Cool.[function with cure mainly] heat-clearing and toxic substances removing; Promoting blood circulation to remove blood stasis.Main cold, fever; Cough due to lung-heat; Gastroenteritis; Dysentery; Acute toothache; Swollen ulcer drug; Eczema; Traumatic injury; Traumatic hemorrhage.
(11) Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) is the herb of Ofthe Primulaceae Herba lysimachiae Paridiformis Lysimachia paridiformis Franch.[nature and flavor] are pungent; Bitter; Warm in nature.[function with cure mainly] expelling wind and removing dampness; Promoting blood circulation and stopping pain; Cough-relieving; Removing toxic substances.Main rheumatalgia; Epigastric pain; Cough; Traumatic injury; Furuncle and phyma treats skin ulcer; Venom.
(12) Herba Clerodendri Serrati, for Verbenaceae three is to the Herb of joint Clerodendrum serratum (L.) Moon, three colored Clerldendrum serratum (L.) Moon var.amplexifotium Moldenke.[nature and flavor] toil; Cool; Slightly poisonous.[return through] spleen; Kidney channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Eliminating stasis to stop pain; Removing toxic substances and promoting subsidence of swelling.Main hygropyretic dysentery; Stranguria; Beriberoid pyretic arthralgia; Dysmenorrhea due to blood stasis; Traumatic injury; Laryngopharynx swelling and pain; Swollen ulcer drug; Urticaria; Malaria.
(13) Ramulus et Folium Rhinacanthi nasuti is branch, the leaf of acanthaceous plant Ramulus et Folium Rhinacanthi nasuti Rhinacanthus nasutus (Linn.) Lindau.[nature and flavor] sweet in the mouth; Micro-hardship; Cold nature.[return through] lung meridian.[function cures mainly] clearing heat and moistening lung; Killing parasites for relieving itching.Main chronic cough; Scabies; Eczema.
(14) Herba Blumeae Balsamiferae is the herb of feverfew Herba Blumeae Balsamiferae Blumea balsamifera (L.) DC..[nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[function cures mainly] expelling wind and removing dampness; Warming middle-JIAO to stop diarrhea; Promoting blood circulation and detoxication.Main anemofrigid cold; Wind syndrome of head is had a headache; Rheumatic arthralgia; Cold-damp dysentery; Taeniasis; Venom; Traumatic pain; Tinea skin ulcer.
(15) Rhizoma seu Herba Elatostematis stewardii is the dry Herb of caprifoliaceae plant Rhizoma seu Herba Elatostematis stewardii Sambucus chinensis Lindl..[nature and flavor] are sweet, sour, temperature.[function with cure mainly] promoting blood circulation and detumescence, expelling wind and removing dampness.For traumatic injury, fracture pain, rheumatic arthritis, oedema due to nephritis, beriberi, scrofula, rubella pruritus, sore and toxic.
(16) Herba Girardiniae Palmatae is Urticaceae girardinia plant Herba Girardiniae Palmatae Girardinia palmata (Forsk.) Gaud., with all herbal medicine.The whole year can adopt, using fresh herb or dry.[nature and flavor] are bitter, pungent, cool.Poisonous.[function with cure mainly] eliminates the phlegm, dampness removing, removing toxic substances.For cough with copious phlegm, edema.Sore is controlled in external.
(17) Radix Kadsurae longipedunculatae is root or the root bark of Schisandraceae Plant Kadsura Longepedunculata Kadsura longipedunculata Finet etGagn..[nature and flavor] are pungent; Bitter; Warm in nature.[return through] spleen; Stomach; Liver Channel.[function cures mainly] regulating QI to relieve pain; To dispel people's dredging collateral; Promoting blood circulation and detumescence.Main stomachache; Stomachache; Rheumatic arthralgia; Dysmenorrhea; Menoxenia; Puerperal abdonimal pain; Laryngopharynx swelling and pain; Hemorrhoid; Innominate toxic swelling; Traumatic injury.
(18) Ardisia mamillata is the Herb of Myrsinacea plant Ardisia mamillata Ardisia mamillata Hance.[nature and flavor] are bitter; Pungent; Cool in nature.[function cures mainly] dispel the wind scrape wet; Heat-clearing and toxic substances removing; Promoting blood circulation and hemostasis.Main air pain of dampness syndrome; Yellow cellulitis; Dysentery; Hemoptysis; Spit blood; Have blood in stool; Amenorrhea; Prolonged lochia; Traumatic injury; Mastalgia; Treat skin ulcer.
(19) Ramulus Uncariae Cum Uncis is the dry stem and branch with belt hook of Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncaria rhynchophylla (Miq.) Miq.ex Havil, Ramulus Uncariae macrophyllae Uncaria.macrophylla Wall., Ramulus Uncariae Cum Uncis Uncaria hirsuta Havil., Uncaria sinensis (Oliv.) Havil. Uncaria sinensis (Oliv) Havil. or stockless fruit Ramulus Uncariae Cum Uncis Uncaria sessilifructus Roxb..[nature and flavor with return through] are sweet, cool.Return liver, pericardium channel.[function with cure mainly] dispelling wind and relieving convulsion, heat clearing away suppressing the hyperactive liver.For liver-wind stirring up internally, infantile convulsion is twitched, and hyperpyrexia convulsion, dysphoric cold, children's's night crying due to fright in infant, pre-eclampsia, has a headache dizzy.
(20) Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra Smilar glabra Roxb..[nature and flavor with return through] are sweet, light, flat.Return liver, stomach warp.[function with cure mainly] detoxify, dehumidifies, easing joint movement.For the limbs contracture caused by syphilis and mercurialism, bones and muscles pain; Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.
(21) optical axis ramie leaf Betel is the Herb of Piperaceae plant optical axis ramie leaf Betel Piper boehmeriaefolium (Miq.) C.DC.var.tomkinense C.DC..[nature and flavor] are pungent; Temperature.[return through] Liver Channel.[function cures mainly] expelling wind and cold; Promoting blood flow to regulate menstruation; Reducing swelling and alleviating pain.Main anemofrigid cold, rheumatic arthralgia, coldness and pain in the epigastrium, toothache, menoxenia, pain is exhausted, treating swelling and pain by traumatic injury, snake bite and insect sting.
(22) Rhizoma Drynariae is the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J.Sm..[nature and flavor with return through] are bitter, temperature.Return liver, kidney channel.[function with cure mainly] pain relieving of curing the wound, the kidney invigorating bone strengthening.External pathogenic wind expelling speckle dispelling.Frustrate for falling to wink, injured bone, lumbago due to renal deficiency, muscles and bones flaccidity is soft, Hiccough and deaf, odontoseisis; External treatment alopecia areata, vitiligo.
(23) kylin leaf is stem and leaf or the root of aroid kylin leaf Epipremnum pinnatum (Linn.) Engl..[nature and flavor] bitter in the mouth; Micro-pungent; Property is put down.[return through] liver; Lung meridian.[function cures mainly] clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis removing toxic substances and promoting subsidence of swelling.Main cold, fever; Epistaxis; Conjunctival congestion and swelling pain; Pertussis; Traumatic injury; Fracture; Rheumatic arthralgia; Phlegm-fire scrofula; Carbuncle furuncle; Venom.
Summary of the invention
The invention provides a kind of can promote fast and effectively union of fracture, alleviate fracture cause swelling, pain Chinese medicine composition, this Chinese medicine composition energy reunion of fractured tendons and bones, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, soothing the channels and quicking the network vessels, evident in efficacy.
Technical scheme of the present invention is:
A kind of Chinese medicine composition for the treatment of fracture, be made up of the Chinese medicine of following weight portion: Herba Lycopodii 20-35 part, nine Ns of power 30-45 parts, Folium Isatidis 40-60 part, profit Caulis Fibraureae 70-90 part, Radix Flemingiae Philippinensis 30-50 part, Herb Gynostemmae Pentaphylli 70-90 part, short holder many 15-35 part, Folium Perillae 40-60 part, milk rattan 20-35 part, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 20-40 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15-35 part, three colored 50-70 parts, Ramulus et Folium Rhinacanthi nasuti 70-90 part, Herba Blumeae Balsamiferae 70-90 part, Rhizoma seu Herba Elatostematis stewardii 50-70 part, Herba Girardiniae Palmatae 30-50 part, Radix Kadsurae longipedunculatae 50-70 part, Mao Jingang 15-25 part, Ramulus Uncariae Cum Uncis 40-60 part, Rhizoma Smilacis Glabrae 15-30 part, optical axis Zhu Ye Betel 70-90 part, Rhizoma Drynariae 30-50 part, kylin leaf 25-35 part.
The Chinese medicine composition of the above treatment fracture, is preferably made up of the Chinese medicine of following weight portion: Herba Lycopodii 25 parts, nine Ns of power 35 parts, Folium Isatidis 50 parts, sharp Caulis Fibraureae 80 parts, Radix Flemingiae Philippinensis 40 parts, Herb Gynostemmae Pentaphylli 80 parts, many 25 parts of short holder, Folium Perillae 50 parts, 25 parts, milk rattan, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 30 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 25 parts, three spend 60 parts, Ramulus et Folium Rhinacanthi nasuti 80 parts, Herba Blumeae Balsamiferae 80 parts, Rhizoma seu Herba Elatostematis stewardii 60 parts, Herba Girardiniae Palmatae 40 parts, Radix Kadsurae longipedunculatae 60 parts, Mao Jingang 20 parts, Ramulus Uncariae Cum Uncis 50 parts, Rhizoma Smilacis Glabrae 25 parts, optical axis ramie leaf Betel 80 parts, Rhizoma Drynariae 40 parts, 30 parts, kylin leaf.
The Chinese medicine composition of the above treatment fracture, can take orally, also can external, can be made into any preparation pharmaceutically allowed.Described preparation is preferably emplastrum, ointment, gel, liniment, tincture, medicated wine, liniment or spray etc., best preferably liniment.
The Chinese medicine composition for the treatment of fracture described in more than one makes the method for liniment, comprises the following steps:
1. take Chinese medicine by following weight portion: Herba Lycopodii 20-35 part, nine Ns of power 30-45 parts, Folium Isatidis 40-60 part, profit Caulis Fibraureae 70-90 part, Radix Flemingiae Philippinensis 30-50 part, Herb Gynostemmae Pentaphylli 70-90 part, short holder many 15-35 part, Folium Perillae 40-60 part, milk rattan 20-35 part, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 20-40 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15-35 part, three colored 50-70 parts, Ramulus et Folium Rhinacanthi nasuti 70-90 part, Herba Blumeae Balsamiferae 70-90 part, Rhizoma seu Herba Elatostematis stewardii 50-70 part, Herba Girardiniae Palmatae 30-50 part, Radix Kadsurae longipedunculatae 50-70 part, Mao Jingang 15-25 part, Ramulus Uncariae Cum Uncis 40-60 part, Rhizoma Smilacis Glabrae 15-30 part, optical axis Zhu Ye Betel 70-90 part, Rhizoma Drynariae 30-50 part, kylin leaf 25-35 part,
2. more than, 23 taste Chinese medicines, are ground into coarse powder, use 50-80% ethanol as solvent, flood after 12-24 hour, and with the speed of 1-3ml per minute slowly percolation, collect percolate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.20-1.30;
3. get polyvinyl alcohol, in water soak 24 hours fully swelling, be heated to 90-100 DEG C and make soluble in water, filter, obtain poly-vinyl alcohol solution;
4. mixed with the weight ratio of 3:1:0.1 by medical material concentrated solution-poly-vinyl alcohol solution-glycerol, add the laurocapram of 1%, mixing, subpackage, to obtain final product.
The present invention is by Herba Lycopodii, nine Niu Li, Folium Isatidis, profit Caulis Fibraureae, Radix Flemingiae Philippinensis, Herb Gynostemmae Pentaphylli, short holder is many, Folium Perillae, milk rattan, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), three flowers, Ramulus et Folium Rhinacanthi nasuti, Herba Blumeae Balsamiferae, Rhizoma seu Herba Elatostematis stewardii, Herba Girardiniae Palmatae, Radix Kadsurae longipedunculatae, Mao Jingang, Ramulus Uncariae Cum Uncis, Rhizoma Smilacis Glabrae, optical axis Zhu Ye Betel, Rhizoma Drynariae, kylin leaf is totally 23 taste Chinese medicine compositions, all medicines share, play reunion of fractured tendons and bones altogether, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the merit of soothing the channels and quicking the network vessels, treatment fracture has significant curative effect, also can be used for because falling, beat, touch, the soft tissue injury caused by reason such as to knock, ligament or joint strain etc., eliminate patient's local pain, swelling, dysfunction and the symptom such as the livid purple addiction speckle of subcutaneous appearance or hematoma.External preparation made by prescription of the present invention, theoretical according to traditional Chinese medical science inner disease outer treat, makes medicine through acupuncture point and skin double-absorption, by shallow table channels, contact the twelve regular channels and run through whole body and reach disease institute, producing good therapeutic effect, is patient, particularly those not easily oral patients, a kind of new route of administration is provided, liver first-pass effect does not occur, do not affect by the factor such as gastric emptying and liver function, not easily produce incompatibility, avoid the untoward reaction that Long-term Oral medicine produces body.The present invention has effect rapidly, and the efficacy of a drug is lasting, applies easy.Liniment obtained by the present invention; directly local skin can be coated during use; thin film is formed after solvent volatilization; drug effect is more lasting, both can protect wound surface, and can discharge contained drug again and play whole body or local therapeutic effects; and preparation technology is simpler; without framed back material, can place for a long time, good stability.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described; but do not limit the scope of the invention and range of application: as used herein, " preferably " and variant thereof refer to the embodiment of the present invention that can provide specific beneficial effect in certain circumstances.But other embodiment also can be preferred under identical or other environment.In addition, the detailed description of one or more preferred embodiment does not represent that other embodiment is useless, and is not intended to the embodiment getting rid of other from category of the present invention.
The preparation of the Chinese medicine composite tincture of one, treatment fracture
Embodiment 1
The Chinese medicine composition for the treatment of fracture makes a method for liniment, comprises the following steps:
1. take Chinese medicine by following weight: Herba Lycopodii 2kg, nine Ns of power 3kg, Folium Isatidis 4kg, sharp Caulis Fibraureae 7kg, Radix Flemingiae Philippinensis 3kg, Herb Gynostemmae Pentaphylli 7kg, the many 1.5kg of short holder, Folium Perillae 4kg, milk rattan 2kg, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 2kg, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 1.5kg, three colored 5kg, Ramulus et Folium Rhinacanthi nasuti 7kg, Herba Blumeae Balsamiferae 7kg, Rhizoma seu Herba Elatostematis stewardii 5kg, Herba Girardiniae Palmatae 3kg, Radix Kadsurae longipedunculatae 5kg, Mao Jingang 1.5kg, Ramulus Uncariae Cum Uncis 4kg, Rhizoma Smilacis Glabrae 1.5kg, optical axis ramie leaf Betel 7kg, Rhizoma Drynariae 3kg, kylin leaf 2.5kg;
2. more than, 23 taste Chinese medicines, are ground into coarse powder, use 50% ethanol as solvent, flood after 12 hours, and with the speed of 1ml per minute slowly percolation, collect percolate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.20;
3. get polyvinyl alcohol, in water soak 24 hours fully swelling, be heated to 90 DEG C and make soluble in water, filter, obtain poly-vinyl alcohol solution;
4. mixed with the weight ratio of 3:1:0.1 by medical material concentrated solution-poly-vinyl alcohol solution-glycerol, add the laurocapram of 1%, mixing, subpackage, to obtain final product.
Embodiment 2
The Chinese medicine composition for the treatment of fracture makes a method for liniment, comprises the following steps:
1. take Chinese medicine by following weight: Herba Lycopodii 3.5kg, nine Ns of power 4.5kg, Folium Isatidis 6kg, sharp Caulis Fibraureae 9kg, Radix Flemingiae Philippinensis 5kg, Herb Gynostemmae Pentaphylli 9kg, the many 3.5kg of short holder, Folium Perillae 6kg, milk rattan 3.5kg, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 4kg, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 3.5kg, three colored 7kg, Ramulus et Folium Rhinacanthi nasuti 9kg, Herba Blumeae Balsamiferae 9kg, Rhizoma seu Herba Elatostematis stewardii 7kg, Herba Girardiniae Palmatae 5kg, Radix Kadsurae longipedunculatae 7kg, Mao Jingang 2.5kg, Ramulus Uncariae Cum Uncis 6kg, Rhizoma Smilacis Glabrae 3kg, optical axis ramie leaf Betel 9kg, Rhizoma Drynariae 5kg, kylin leaf 3.5kg;
2. more than, 23 taste Chinese medicines, are ground into coarse powder, use 80% ethanol as solvent, flood after 24 hours, and with the speed of 3ml per minute slowly percolation, collect percolate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.30;
3. get polyvinyl alcohol, in water soak 24 hours fully swelling, be heated to 100 DEG C and make soluble in water, filter, obtain poly-vinyl alcohol solution;
4. mixed with the weight ratio of 3:1:0.1 by medical material concentrated solution-poly-vinyl alcohol solution-glycerol, add the laurocapram of 1%, mixing, subpackage, to obtain final product.
Embodiment 3
The Chinese medicine composition for the treatment of fracture makes a method for liniment, comprises the following steps:
1. take Chinese medicine by following weight: Herba Lycopodii 2.5kg, nine Ns of power 3.5kg, Folium Isatidis 5kg, sharp Caulis Fibraureae 8kg, Radix Flemingiae Philippinensis 4kg, Herb Gynostemmae Pentaphylli 8kg, the many 2.5kg of short holder, Folium Perillae 5kg, milk rattan 2.5kg, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 3kg, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 2.5kg, three colored 6kg, Ramulus et Folium Rhinacanthi nasuti 8kg, Herba Blumeae Balsamiferae 8kg, Rhizoma seu Herba Elatostematis stewardii 6kg, Herba Girardiniae Palmatae 4kg, Radix Kadsurae longipedunculatae 6kg, Mao Jingang 2kg, Ramulus Uncariae Cum Uncis 5kg, Rhizoma Smilacis Glabrae 2.5kg, optical axis ramie leaf Betel 8kg, Rhizoma Drynariae 4kg, kylin leaf 3kg;
2. more than, 23 taste Chinese medicines, are ground into coarse powder, use 60% ethanol as solvent, flood after 18 hours, and with the speed of 2ml per minute slowly percolation, collect percolate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.25;
3. get polyvinyl alcohol, in water soak 24 hours fully swelling, be heated to 95 DEG C and make soluble in water, filter, obtain poly-vinyl alcohol solution;
4. mixed with the weight ratio of 3:1:0.1 by medical material concentrated solution-poly-vinyl alcohol solution-glycerol, add the laurocapram of 1%, mixing, subpackage, to obtain final product.
Two, pharmacodynamics test
1. on the microcirculatory impact of Mice Auricle
Get mice, be divided into blank group (80% ethanol), positive controls (YUNNAN BAIYAO DING), embodiment group (embodiment 3 sample) at random, often organize 10.Each Mus lumbar injection pentobarbital sodium 25mg/kg, auricle hair is pruned with eye scissors after anesthesia, mice is fixed, open and flat auricle and be coated with a little cedar oil in surface, be placed on microscope carrier, with Mice Auricle microcirculation before 40 ~ 100 times of sem observation administrations, record each Mus auricle arteriole (A), the bore of thin vein (V), capillary open amount.Then be coated with outside left ear two sides and give corresponding tested medicinal liquid 0.1g, administration after 30 minutes, then measures auricle arteriole (A), the bore of thin vein (V), capillary open amount.Result shows, embodiment group can make Mice Auricle arteriole (A), thin vein (V) external caliber obviously increases, and auricle capillary open increasing number, in table 1.
Table 1 is on the microcirculatory impact of Mice Auricle
2. on Carrageenan causes the impact of mice foot swelling
Get mice, every mice right back toes portion subcutaneous injection 0.5% carrageenin suspension 40 μ l causes inflammation.To cause mice random packet after inflammation, be divided into blank group (80% ethanol), positive controls (YUNNAN BAIYAO DING), embodiment group (embodiment 3 sample) at random, often organize 10.After grouping, mice starts administration, smears and gives corresponding test medicine 0.2g, successive administration 3 days, every day 1 time in right back toes portion, in last administration after 4 hours, puts to death mice, gets rear biped and be equal to position, accurately weigh, using left and right foot weight difference as swelling.Result shows, embodiment group on Carrageenan causes mice foot swelling inflammation has obvious inhibitory action, in table 2.
Table 2 on Carrageenan causes the impact of mice toes inflammation
3. analgesic test
Get mice, be divided into blank group (80% ethanol), positive controls (YUNNAN BAIYAO DING), embodiment group (embodiment 3 sample) at random, often organize 10.The front hot plate method of medication measures the pain threshold of each mice.Each mice two hind leg is smeared and is given corresponding test medicine each 0.2g, and after medicine, 20 minutes reusable heat plate methods measure the pain threshold of each Mus respectively.Result shows, embodiment group has obvious analgesic activity, in table 3.
Table 3 analgesic test
Three, clinical practice test
1. case selection standard
A. inclusive criteria: " the disease of tcm Standardization of diagnosis and curative effect " compiled with reference to State Administration of Traditional Chinese Medicine.
(1) clinical symptoms: pain appears in traumatic injury, swelling, bony crepitus, limitation of activity, the livid purple addiction speckle of subcutaneous appearance or hematoma.
(2) diagnosis that can clearly fracture of x-ray inspection, can confirm the localized variation such as classification of fracture, displacement mode, fracture end form.
(3) age 10-65 year.
B. Excluded cases standard:
(1) three degree of open fracture concurrent infection or serious visceral organ injury.
(2) those who are allergic to this drug.
(3) the severe primary diseases such as cardiovascular, lung, liver, kidney, brain, hemopoietic and hormonal system are associated with.
(4) psychotic.
(5) take and to cure mainly akin medicine with this medicine function and to the influential medicine of union of fracture.
(6) not according to regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment and safety judgement person.
2. therapeutic scheme
Adopt conventional manual reduction, plintlet or plaster fixing.By affected part warm water cleaning, dry, with sterilized cotton ball or cotton swab sterilization, by the embodiment of the present invention 3 sample application affected part, every day 3-5 time, the thickness of coating can be increased according to the state of an illness.It within 1 month, was 1 course for the treatment of.Severe patient can adopt invention Chinese medicine composition to be decocted in water for oral dose.
3. efficacy assessment standard
Draft with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
(1) fully recover: union of fracture, without local swelling, tenderness, activity freely.
(2) effective: the healing of fracture major part, function of joint is improved, and there are swelling, tenderness in local.
(3) effective: fracture portions heals, fracture site swelling, tenderness.
(4) invalid: fracture does not connect, and without growth of spur, ankylosis, function is poor.
4. clinical efficacy
By the patient selecting 65 examples to meet above-mentioned case selection condition, man: 37 examples, female: 28 examples.Fracture site: radius 15 example, humerus 12 example, femur 11 example, chi scratch bone 20 example, lumbar vertebra 7 example.
The results detailed in following table.
Clinical efficacy survey result table
Clinical test results shows: adopt the above-mentioned case of traditional Chinese medicine composition for treating of the present invention, cure rate 90.8%, and effective percentage treats 100%, evident in efficacy, is showed no irritant reaction to normal and damaged skin, also there are no skin hypersensitivity reaction, and use safety.Illustrate that the present invention has the merit of reunion of fractured tendons and bones, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, soothing the channels and quicking the network vessels, treatment fracture has significant curative effect, also can be used for because of soft tissue injury, ligament or the joint strain etc. caused by reasons such as falling, beat, touch, knock, eliminate patient's local pain, swelling, dysfunction and the symptom such as the livid purple addiction speckle of subcutaneous appearance or hematoma.
4. model case
(1) poplar, man, 61 years old, falls and hurts oneself, and injury is red and swollen, hurt like hell, and can not walk, X-ray is shown as neck of femur oblique fracture, and routine disinfection wound, fracture site fixed by plintlet.
Medicine of the present invention is adopted to take orally, prescription is: Herba Lycopodii 10g, nine Ns of power 15g, Folium Isatidis 20g, sharp Caulis Fibraureae 30g, Radix Flemingiae Philippinensis 20g, Herb Gynostemmae Pentaphylli 40g, the many 13g of short holder, Folium Perillae 25g, milk rattan 10g, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 10g, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15g, three colored 30g, Ramulus et Folium Rhinacanthi nasuti 40g, Herba Blumeae Balsamiferae 40g, Rhizoma seu Herba Elatostematis stewardii 30g, Herba Girardiniae Palmatae 20g, Radix Kadsurae longipedunculatae 30g, Mao Jingang 10g, Ramulus Uncariae Cum Uncis 20g, Rhizoma Smilacis Glabrae 10g, optical axis ramie leaf Betel 40g, Rhizoma Drynariae 20g, kylin leaf 15g, every day 1 pair, be decocted in water for oral dose, divide and take for 3 times, serve on 5.
The another employing embodiment of the present invention 3 sample application affected part, every day 5 times.Obviously alleviate after 5 days pain, redness disappears.After 1 month, union of fracture, without local swelling, tenderness, can normally walk, recovery from illness.
(2) blue certain, female, 12 years old, the Shi Congshu that plays falls, and is diagnosed as right side middle clavicle fracture, affected part is red and swollen, tenderness, limitation of activity.Conventional manual reduction, adopt the embodiment of the present invention 3 sample application affected part, every day 4 times, obviously alleviate after 5 days pain, redness disappears.After 1 month, without local swelling, tenderness, union of fracture, recovery from illness.
(3) land, man, 34 years old, be thrown out of outside car after overturning, hypomere obvious tumefaction, tenderness in right upper arm, had bone rubbing feeling, right elbow joint deformity, moving obstacle, right forearm stage casing angulation deformity, swelling tenderness.X-ray is shown as right humerus transverse fracture.Right elbow joint manual reduction, right humeral fracture manual reduction, right upper extremity plaster slab extenal fixation.Adopt the embodiment of the present invention 3 sample application affected part, every day 5 times, obviously alleviate after 5 days pain, redness disappears.1 month rear right elbow joint function recovers, and coating number of times changes every day 3 times into, and after 2 months, union of fracture, right shoulder, elbow joint and forearm activity are normal, recovery from illness.
Claims (5)
1. treat the Chinese medicine composition of fracture for one kind, it is characterized in that, be made up of the Chinese medicine of following weight portion: Herba Lycopodii 20-35 part, nine Ns of power 30-45 parts, Folium Isatidis 40-60 part, profit Caulis Fibraureae 70-90 part, Radix Flemingiae Philippinensis 30-50 part, Herb Gynostemmae Pentaphylli 70-90 part, short holder many 15-35 part, Folium Perillae 40-60 part, milk rattan 20-35 part, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 20-40 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15-35 part, three colored 50-70 parts, Ramulus et Folium Rhinacanthi nasuti 70-90 part, Herba Blumeae Balsamiferae 70-90 part, Rhizoma seu Herba Elatostematis stewardii 50-70 part, Herba Girardiniae Palmatae 30-50 part, Radix Kadsurae longipedunculatae 50-70 part, Mao Jingang 15-25 part, Ramulus Uncariae Cum Uncis 40-60 part, Rhizoma Smilacis Glabrae 15-30 part, optical axis Zhu Ye Betel 70-90 part, Rhizoma Drynariae 30-50 part, kylin leaf 25-35 part.
2. treat the Chinese medicine composition of fracture according to claim 1, it is characterized in that, be made up of the Chinese medicine of following weight portion: Herba Lycopodii 25 parts, nine Ns of power 35 parts, Folium Isatidis 50 parts, profit Caulis Fibraureae 80 parts, Radix Flemingiae Philippinensis 40 parts, Herb Gynostemmae Pentaphylli 80 parts, many 25 parts of short holder, Folium Perillae 50 parts, 25 parts, milk rattan, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 30 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 25 parts, spend 60 parts for three, Ramulus et Folium Rhinacanthi nasuti 80 parts, Herba Blumeae Balsamiferae 80 parts, Rhizoma seu Herba Elatostematis stewardii 60 parts, Herba Girardiniae Palmatae 40 parts, Radix Kadsurae longipedunculatae 60 parts, Mao Jingang 20 parts, Ramulus Uncariae Cum Uncis 50 parts, Rhizoma Smilacis Glabrae 25 parts, optical axis Zhu Ye Betel 80 parts, Rhizoma Drynariae 40 parts, 30 parts, kylin leaf.
3. according to claim 1 or 2, treat the Chinese medicine composition of fracture, it is characterized in that, described Chinese medicine composition makes any preparation pharmaceutically allowed.
4. treat the Chinese medicine composition of fracture according to claim 3, it is characterized in that, described preparation is emplastrum, ointment, gel, liniment, tincture, medicated wine, liniment or spray.
5. the Chinese medicine composition for the treatment of fracture as claimed in claim 1 makes a method for liniment, it is characterized in that, comprises the following steps:
(1) Chinese medicine is taken by following weight portion: Herba Lycopodii 20-35 part, nine Ns of power 30-45 parts, Folium Isatidis 40-60 part, profit Caulis Fibraureae 70-90 part, Radix Flemingiae Philippinensis 30-50 part, Herb Gynostemmae Pentaphylli 70-90 part, short holder many 15-35 part, Folium Perillae 40-60 part, milk rattan 20-35 part, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 20-40 part, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15-35 part, three colored 50-70 parts, Ramulus et Folium Rhinacanthi nasuti 70-90 part, Herba Blumeae Balsamiferae 70-90 part, Rhizoma seu Herba Elatostematis stewardii 50-70 part, Herba Girardiniae Palmatae 30-50 part, Radix Kadsurae longipedunculatae 50-70 part, Mao Jingang 15-25 part, Ramulus Uncariae Cum Uncis 40-60 part, Rhizoma Smilacis Glabrae 15-30 part, optical axis Zhu Ye Betel 70-90 part, Rhizoma Drynariae 30-50 part, kylin leaf 25-35 part,
(2) more than, 23 taste Chinese medicines, are ground into coarse powder, use 50-80% ethanol as solvent, flood after 12-24 hour, and with the speed of 1-3ml per minute slowly percolation, collect percolate, being concentrated into 60 DEG C of relative densities is the concentrated solution of 1.20-1.30;
(3) get polyvinyl alcohol, in water soak 24 hours fully swelling, be heated to 90-100 DEG C and make soluble in water, filter, obtain poly-vinyl alcohol solution;
(4) mixed with the weight ratio of 3:1:0.1 by medical material concentrated solution-poly-vinyl alcohol solution-glycerol, add the laurocapram of 1%, mixing, subpackage, to obtain final product.
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Application publication date: 20150429 |