CN103316146B - Traditional Chinese medicinal preparation for anesthesia - Google Patents
Traditional Chinese medicinal preparation for anesthesia Download PDFInfo
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- CN103316146B CN103316146B CN201310300636.3A CN201310300636A CN103316146B CN 103316146 B CN103316146 B CN 103316146B CN 201310300636 A CN201310300636 A CN 201310300636A CN 103316146 B CN103316146 B CN 103316146B
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Abstract
The invention discloses a traditional Chinese medicinal preparation for anesthesia. Effective components of the traditional Chinese medicinal preparation comprise the following raw materials: keel, spine date seed, albizia bark, Datura stramonium, henbane, caltrop, monkshood, Aconitum kusnezoffii, clove, chinese fevervine herb and root, the root bark of the peony tree, eucommia, natural indigo, common fenugreek seed, honeysuckle flower and bighead atractylodes rhizome. The traditional Chinese medicinal preparation is prepared by compatibility of a plurality of medicinal materials, and has advantages of fast effectiveness, short time of duration, high anaesthesia efficiency, strong controllability during operation and fast revival after operation. After operation, anaesthetic drugs can be timely metabolized and expelled out of the body. The traditional Chinese medicinal preparation has a good curative effect of complications caused by anaesthesia. The traditional Chinese medicinal preparation provided by the invention also has an obvious pain-relieving effect as well as an antishock effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of anesthesia Chinese medicine preparation.
Background technology
In clinical operation, anesthesia be while performing a surgical operation or be eliminate pain while carrying out diagnostic test operation, ensure patient safety, create the whole bag of tricks that good surgical condition is taked.Patient, when performing the operation or diagnostic test operates, can feel pain, need to make it swound by anesthetics or other modes.Operation or inspection operation also can cause psychentonia and reflexive untoward reaction, as gastrointestinal surgery can cause nausea, vomit.Long uncomfortable position (as ventricumbent position), what can increase patient does not accommodate misery, therefore should make patient in comfortable, quiet environment, reactionless to pessimal stimulation, in situation about temporarily losing the memory of, undergos surgery.
At present, generally adopt the method for injection procaine or conduction block anaesthetize or carry out topical anesthesia by pad pasting.Existing anesthesia method operation is more loaded down with trivial details, also has anesthetic risks simultaneously.Therefore, on market, be badly in need of a kind of anesthesia with Chinese medicine preparation better to implement local anesthesia.
Summary of the invention
The invention provides a kind of anesthesia Chinese medicine preparation, for pure Chinese medicinal preparation, by multi-flavor medical material compatibility, formed, have advantages of that instant effect, persistent period are short, anesthesia usefulness is high, in art strong, the art of controllability finish revive fast, postoperative can be in time by Anesthetics Metabolism and excrete, antagonism has good curative effect because of the complication that anesthesia causes; It is obvious that Chinese medicine preparation of the present invention also has analgesic effect, antishock effect.
For achieving the above object, being implemented as follows of technical scheme of the present invention:
An anesthesia Chinese medicine preparation, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
27～64 parts of 28～66 portions of Flos Daturae of 29～68 portions of Cortex Albiziaes of 30～70 parts of Semen Ziziphi Spinosaes of Os Draconis
23～56 parts of 24～58 portions of Radix Aconiti Kusnezoffii of 25～60 portions of Radix Aconitis of 26～62 portions of Fructus Tribulis of Semen Hyoscyami
19～48 parts of 20～50 parts of Cortexs Eucommiae of 21～52 parts of Cortex Moutans of 22～54 parts of Herba Paederiaes of Flos Caryophylli
15～40 parts of 16～42 parts of Rhizoma Atractylodis Macrocephalaes of 17～45 portions of Flos Loniceraes of 18～46 parts of Semen Trigonellae of Indigo Naturalis.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
30～61 parts of 31～63 portions of Flos Daturae of 32～65 portions of Cortex Albiziaes of 33～67 parts of Semen Ziziphi Spinosaes of Os Draconis
26～53 parts of 27～55 portions of Radix Aconiti Kusnezoffii of 28～57 portions of Radix Aconitis of 29～59 portions of Fructus Tribulis of Semen Hyoscyami
22～45 parts of 23～47 parts of Cortexs Eucommiae of 24～49 parts of Cortex Moutans of 25～51 parts of Herba Paederiaes of Flos Caryophylli
18～37 parts of 19～39 parts of Rhizoma Atractylodis Macrocephalaes of 20～42 portions of Flos Loniceraes of 21～44 parts of Semen Trigonellae of Indigo Naturalis.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
32～57 parts of 33～59 portions of Flos Daturae of 35～61 portions of Cortex Albiziaes of 37～63 parts of Semen Ziziphi Spinosaes of Os Draconis
28～50 parts of 29～51 portions of Radix Aconiti Kusnezoffii of 30～53 portions of Radix Aconitis of 32～55 portions of Fructus Tribulis of Semen Hyoscyami
24～42 parts of 25～44 parts of Cortexs Eucommiae of 26～45 parts of Cortex Moutans of 27～48 parts of Herba Paederiaes of Flos Caryophylli
20～34 parts of 21～36 parts of Rhizoma Atractylodis Macrocephalaes of 22～39 portions of Flos Loniceraes of 23～41 parts of Semen Trigonellae of Indigo Naturalis.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
45 parts of 46 portions of Flos Daturae of 48 portions of Cortex Albiziaes of 50 parts of Semen Ziziphi Spinosaes of Os Draconis
39 parts of 40 portions of Radix Aconiti Kusnezoffii of 42 portions of Radix Aconitis of 44 portions of Fructus Tribulis of Semen Hyoscyami
32 parts of 34 parts of Cortexs Eucommiae of 35 parts of Cortex Moutans of 37 parts of Herba Paederiaes of Flos Caryophylli
26 parts of 28 parts of Rhizoma Atractylodis Macrocephalaes of 29 portions of Flos Loniceraes of 31 parts of Semen Trigonellae of Indigo Naturalis.
Anaesthetize the preparation method with Chinese medicine preparation, preparation process is as follows:
(1) Os Draconis, Semen Hyoscyami, Fructus Tribuli, Radix Aconiti, Flos Caryophylli, Cortex Moutan, the Cortex Eucommiae, Semen Trigonellae, Flos Lonicerae adding distil water are boiled and extract 3 times, add first 6-10 and doubly measure distilled water immersion 3-4 hour, heated and boiled is extracted 2-3 hour; Add for the second time 3-5 and doubly measure distilled water heated and boiled extraction 1-2 hour, add for the third time 2-3 and doubly measure distilled water heated and boiled extraction 0.5-1 hour, merge extractive liquid,, filters, and obtains filtrate, is condensed into dry extract standby;
(2) gained dry extract in step (1) being added to volumetric concentration is 90% alcoholic solution, and standing over night extracts supernatant, and the extractum precipitating is standby;
(3) Semen Ziziphi Spinosae is ground into powder, crossed 200 order fine powders, powder is soaked 1～2 hour, filter, get solution for standby;
(4) by Cortex Albiziae dedust bits, with wine, soak, clean, take out, dry, be crushed into powder, standby;
(5) Rhizoma Atractylodis Macrocephalae, Indigo Naturalis, Radix Aconiti Kusnezoffii, Herba Paederiae, Flos Daturae 5 taste cflushes is clean, microwave drying, pulverizing is 200 orders, adding volumetric concentration is that 75% alcoholic solution extracts 1.5-2 in 70-90 ℃ of hot reflux
Hour, elimination medicinal residues, are condensed into extractum and save backup;
(6) by step (2) with after the extractum making in step (5) mixes again and the solution of step (3) gained mix with the powder of step (4) gained, described anesthesia Chinese medicine preparation.
The property of medicine of the present invention's Chinese medicine used is as follows:
Os Draconis: sweet, puckery, flat.Astringing QI is by wet, and only night sweat, calms the nerves, unsmoothing the sperm and stopping bleeding.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.Os Draconis have tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing.< < does not record > > and carries: " Os Draconis are treated trusted subordinate's stuffy sensation with restlessness, and extremity flaccidity is withered, sweating; night is sleeping from frightened; be enraged, latent pathogen must not be panted under the heart, cellulitis in acute appendicitis; the erosion of the vulva; hidroschesis, urine reducing, hematuria; support spirit, determine soul.”
Semen Ziziphi Spinosae: sweet, flat.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.< < book on Chinese herbal medicine newer > > carries: " suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, beneficial will is breathed out surely, hearing-improing and eyesight improving."
Cortex Albiziae: property is flat, sweet in the mouth; Nontoxic; GUIXIN, Liver Channel.The effect with resolving stagnation for tranquilization, promoting blood circulation and detumescence.The merit that has resolving depression and blood, mind calming, subduing inflammation.Controlling irritability, melancholy insomnia, lung abscess skin ulcer swells, falls and flutter the diseases such as grieved.< < detailed outline > > carries: " and blood, detumescence, pain relieving."
Flos Daturae: acrid in the mouth, warm in nature, very toxic.Flower can curing rheumatism, and Zhichuan analgesic therapy, can control infantile convulsion and asthma of cold-type, decocts soup and washes and control all wind insensitive impediment and the disturbance of lower legs due to pathogenic cold and dampness.The analgesic activity of petal is especially good, can training the mind dysmenorrhoea etc.Flos Daturae has spasmolytic, calmness, analgesia, the function of anesthesia.
Semen Hyoscyami: toil, temperature, poisonous.Determine epilepsy, pain relieving.Control demented, acute infantile convulsion, migratory arthralgia faint pain, neuralgia, breathes with cough, stomachache, chronic dysentery, chronic diarrhea, proctoptosis, toothache, carbuncle, malignant boil.< < Bencao Shiyi > > carries: " main mass beside the umbilicus, evil removing is by wind."
Fructus Tribuli: slightly warm in nature, acrid in the mouth, hardship.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Be used for having a headache dizzy, distending pain in the chest and hypochondrium, breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus.
Radix Aconiti: acrid in the mouth, hardship, hot in nature, poisonous; GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic, for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.According to < < pearl sac addendum Yaoxing Fu > >, carry: " the cold-evil of loose all wind; The cold type of pain of broken various masses." modern medicine study confirmation, the contained aconitine of Radix Aconiti has analgesic activity, and the outer used time can be benumbed the peripheral termination of nerve, produces local anesthesia and analgesia, antiinflammation.
Radix Aconiti Kusnezoffii: acrid in the mouth, hardship.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type have a pain, pain relieving.
Flos Caryophylli: acrid in the mouth, warm in nature.Regulating QI and lowering the adverseness, warming middle-JIAO to relieve pain, warming the kidney.Cure mainly coldness and pain in the epigastrium, singultus, nauseating, vomiting; The sexual impotence of insufficiency of kidney-YANG, and the inferior disease of cold-damp band.< < Compendium of Materia Medica > > carries: " Flos Caryophylli is treated kidney qi, sensation of gas rushing, pain over the perineum, stomachache, tonifying YANG, warm waist knee joint." Flos Caryophylli has antioxidation, removes the effect of free radical and control alopecia.
Herba Paederiae: sweet acid, flat.Expelling wind and activating blood circulation, analgesic antidotal, dyspepsia and intestinal stasis relieving, dehumidifying detumescence.Dispelling the wind and dampness pathogens pain, diarrhoea dysentery, dirty abdomen pain, deficiency of vital energy edema, dizzy lack of appetite, hepatosplenomegaly, scrofula, acute appendicitis, innominate toxic swelling, traumatic injury.The conventional Chinese herbal medicine > > in < < Shanghai carries: " dispel the wind, invigorate blood circulation, pain relieving, detumescence.Dispelling the wind and dampness pathogens is ached, traumatic injury, hepatosplenomegaly, innominate toxic swelling."
Cortex Moutan: cold in nature, bitter in the mouth; Cool; Be slightly cold.Return liver, kidney, lung meridian.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.< < Compendium of Materia Medica > > carries: " nourishing YIN to lower pathogenic fire is separated speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, the contained paeonol of Cortex Moutan and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has inhibition Platelet; Paeonol has the effects such as the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and atherosclerosis, diuresis, antiulcer.
The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature; Enter Liver Channel, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening.Cure mainly spinal column ache, rheumatic arthralgia.According to < < Essential Recipes for Emergent Use Worth A Thousand Gold > >, carry: " function wind-damp dispelling, stopping numbness pain, liver and kidney tonifying; the damp that is affected by the cold that fills blood, chills and pain of the waist and kness, podomere joint stuffiness; or benumb meciless, fear of cold happiness temperature." modern medicine study confirmation, the Cortex Eucommiae has sedation to nerve centre, can strengthen the immunologic function of cell, promotes cortisol secretion and cAMP in plasma and cGMP metabolism.
Indigo Naturalis: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Semen Trigonellae: hardship, temperature.Kidney-replenishing, dispelling cold and dampness.Control colic of cold type, abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.< < Jiayou Bencao > > carries: " pivot deficiency of five ZANG-organs cold air.Radix Aconiti Lateralis Preparata, sulfur, control suffer from a deficiency of the kidney cold, abdomen side of body distension, greenish complexion is black; The fragrant son of get Huai, Semen Persicae, control bladder gas."
Flos Lonicerae: sweet in the mouth, micro-hardship, delicate fragrance, property is pungent, cold; Return lung, stomach, the heart, large intestine channel.Be described as the good medicine of heat-clearing and toxic substances removing from ancient times.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, kind removing summer-heat blood poison also, and for various febrile diseases, all effect is remarkable.The < < hall of accumulating virtue carries through proved recipe > >: " half bowl, Flos Lonicerae nature juice, decoct eight sub-services it, with dregs, apply, the Tuoli that relieves internal heat, loose gas and blood, its merit solely wins." modern medicine study confirms: Flos Lonicerae has the loose evil effect of the heat of dredging, to affection due to external wind and heat or epidemic febrile disease from the beginning of, fever of the body headache, vexedly sleep less, coma crimson tongue, dry mouth and throat etc. have certain effect.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature.Spleen invigorating, and in, dampness, diuretic.Cure mainly deficiency-weakness of spleen-QI, spiritlessness and weakness, fluid-retention stagnating in the interior, dysuria, edema.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention is formed by multi-flavor medical material compatibility, have advantages of that instant effect, persistent period are short, anesthesia usefulness is high, in art strong, the art of controllability finish revive fast, postoperative can be in time by Anesthetics Metabolism and excrete, antagonism has good curative effect because of the complication that anesthesia causes; It is obvious that Chinese medicine preparation of the present invention also has analgesic effect, antishock effect.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is done further and supplemented, but do not limit the present invention in any way.Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Os Draconis 50g Semen Ziziphi Spinosae 48g Cortex Albiziae 46g Flos Daturae 45g
Semen Hyoscyami 44g Fructus Tribuli 42g Radix Aconiti 40g Radix Aconiti Kusnezoffii 39g
Flos Caryophylli 37g Herba Paederiae 35g Cortex Moutan 34g Cortex Eucommiae 32g
Indigo Naturalis 31g Semen Trigonellae 29g Flos Lonicerae 28g Rhizoma Atractylodis Macrocephalae 26g.
Anaesthetize the preparation method with Chinese medicine preparation, preparation process is as follows:
(1) Os Draconis, Semen Hyoscyami, Fructus Tribuli, Radix Aconiti, Flos Caryophylli, Cortex Moutan, the Cortex Eucommiae, Semen Trigonellae, Flos Lonicerae adding distil water are boiled and extract 3 times, add first 6-10 and doubly measure distilled water immersion 3-4 hour, heated and boiled is extracted 2-3 hour; Add for the second time 3-5 and doubly measure distilled water heated and boiled extraction 1-2 hour, add for the third time 2-3 and doubly measure distilled water heated and boiled extraction 0.5-1 hour, merge extractive liquid,, filters, and obtains filtrate, is condensed into dry extract standby;
(2) gained dry extract in step (1) being added to volumetric concentration is 90% alcoholic solution, and standing over night extracts supernatant, and the extractum precipitating is standby;
(3) Semen Ziziphi Spinosae is ground into powder, crossed 200 order fine powders, powder is soaked 1～2 hour, filter, get solution for standby;
(4) by Cortex Albiziae dedust bits, with wine, soak, clean, take out, dry, be crushed into powder, standby;
(5) Rhizoma Atractylodis Macrocephalae, Indigo Naturalis, Radix Aconiti Kusnezoffii, Herba Paederiae, Flos Daturae 5 taste cflushes is clean, microwave drying, pulverizing is 200 orders, adding volumetric concentration is that 75% alcoholic solution extracts 1.5-2 hour in 70-90 ℃ of hot reflux, elimination medicinal residues, are condensed into extractum and save backup;
(6) by step (2) with after the extractum making in step (5) mixes again and the solution of step (3) gained mix with the powder of step (4) gained, described Chinese drug anesthesia Chinese medicine preparation.
Usage and dosage: for oral administration, one time 1, within preoperative 10 minutes, take.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Os Draconis 39g Semen Ziziphi Spinosae 37g Cortex Albiziae 35g Flos Daturae 34g
Semen Hyoscyami 34g Fructus Tribuli 32g Radix Aconiti 31g Radix Aconiti Kusnezoffii 30g
Flos Caryophylli 29g Herba Paederiae 28g Cortex Moutan 27g Cortex Eucommiae 26g
Indigo Naturalis 25g Semen Trigonellae 24g Flos Lonicerae 23g Rhizoma Atractylodis Macrocephalae 22g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Os Draconis 35g Semen Ziziphi Spinosae 34g Cortex Albiziae 33g Flos Daturae 32g
Semen Hyoscyami 31g Fructus Tribuli 30g Radix Aconiti 29g Radix Aconiti Kusnezoffii 28g
Flos Caryophylli 27g Herba Paederiae 26g Cortex Moutan 25g Cortex Eucommiae 24g
Indigo Naturalis 23g Semen Trigonellae 22g Flos Lonicerae 21g Rhizoma Atractylodis Macrocephalae 20g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Os Draconis 32g Semen Ziziphi Spinosae 31g Cortex Albiziae 30g Flos Daturae 29g
Semen Hyoscyami 28g Fructus Tribuli 27g Radix Aconiti 26g Radix Aconiti Kusnezoffii 25g
Flos Caryophylli 24g Herba Paederiae 23g Cortex Moutan 22g Cortex Eucommiae 21g
Indigo Naturalis 20g Semen Trigonellae 19g Flos Lonicerae 18g Rhizoma Atractylodis Macrocephalae 17g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
Chinese medicine preparation of the present invention is through clinical observation patient 100 examples, and Chinese medicine preparation effective percentage of the present invention is remarkable, and in clinical observation process, exact efficacy, does not find that patient has untoward reaction and anaphylaxis.
Therapeutic Method:
For oral administration, one time 1, within preoperative 10 minutes, take.According to conditions of patients weight, calculate anesthesia duration, short time, minor operation clothes for patients be with 1, for a long time, major operation clothes for patients is with 2.
Curative effect determinate standard:
(1) effective: painless in art;
(2) effective: in art, pain has the sense of alleviating;
(3) invalid: in art, pain is without alleviating sense.
Therapeutic outcome:
After Chinese medicine preparation of the present invention is taken in clinical observation, effective 75 examples, effective 22 examples, invalid 3 examples, total effective rate 97%, reaches clinical application standard completely.
Chinese medicine preparation of the present invention is formed by multi-flavor medical material compatibility, have advantages of that instant effect, persistent period are short, anesthesia usefulness is high, in art strong, the art of controllability finish revive fast, postoperative can be in time by Anesthetics Metabolism and excrete, antagonism has good curative effect because of the complication that anesthesia causes; It is obvious that Chinese medicine preparation of the present invention also has analgesic effect, antishock effect.
Claims (5)
1. an anesthesia Chinese medicine preparation, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
27～64 parts of 28～66 portions of Flos Daturae of 29～68 portions of Cortex Albiziaes of 30～70 parts of Semen Ziziphi Spinosaes of Os Draconis
23～56 parts of 24～58 portions of Radix Aconiti Kusnezoffii of 25～60 portions of Radix Aconitis of 26～62 portions of Fructus Tribulis of Semen Hyoscyami
19～48 parts of 20～50 parts of Cortexs Eucommiae of 21～52 parts of Cortex Moutans of 22～54 parts of Herba Paederiaes of Flos Caryophylli
15～40 parts of 16～42 parts of Rhizoma Atractylodis Macrocephalaes of 17～45 portions of Flos Loniceraes of 18～46 parts of Semen Trigonellae of Indigo Naturalis.
2. a kind of anesthesia Chinese medicine preparation according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
30～61 parts of 31～63 portions of Flos Daturae of 32～65 portions of Cortex Albiziaes of 33～67 parts of Semen Ziziphi Spinosaes of Os Draconis
26～53 parts of 27～55 portions of Radix Aconiti Kusnezoffii of 28～57 portions of Radix Aconitis of 29～59 portions of Fructus Tribulis of Semen Hyoscyami
22～45 parts of 23～47 parts of Cortexs Eucommiae of 24～49 parts of Cortex Moutans of 25～51 parts of Herba Paederiaes of Flos Caryophylli
18～37 parts of 19～39 parts of Rhizoma Atractylodis Macrocephalaes of 20～42 portions of Flos Loniceraes of 21～44 parts of Semen Trigonellae of Indigo Naturalis.
3. a kind of anesthesia Chinese medicine preparation according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
32～57 parts of 33～59 portions of Flos Daturae of 35～61 portions of Cortex Albiziaes of 37～63 parts of Semen Ziziphi Spinosaes of Os Draconis
28～50 parts of 29～51 portions of Radix Aconiti Kusnezoffii of 30～53 portions of Radix Aconitis of 32～55 portions of Fructus Tribulis of Semen Hyoscyami
24～42 parts of 25～44 parts of Cortexs Eucommiae of 26～45 parts of Cortex Moutans of 27～48 parts of Herba Paederiaes of Flos Caryophylli
20～34 parts of 21～36 parts of Rhizoma Atractylodis Macrocephalaes of 22～39 portions of Flos Loniceraes of 23～41 parts of Semen Trigonellae of Indigo Naturalis.
4. a kind of anesthesia Chinese medicine preparation according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
45 parts of 46 portions of Flos Daturae of 48 portions of Cortex Albiziaes of 50 parts of Semen Ziziphi Spinosaes of Os Draconis
39 parts of 40 portions of Radix Aconiti Kusnezoffii of 42 portions of Radix Aconitis of 44 portions of Fructus Tribulis of Semen Hyoscyami
32 parts of 34 parts of Cortexs Eucommiae of 35 parts of Cortex Moutans of 37 parts of Herba Paederiaes of Flos Caryophylli
26 parts of 28 parts of Rhizoma Atractylodis Macrocephalaes of 29 portions of Flos Loniceraes of 31 parts of Semen Trigonellae of Indigo Naturalis.
5. as described in claim 1-4 any one, anaesthetize the preparation method with Chinese medicine preparation, it is characterized in that: preparation process is as follows:
(1) Os Draconis, Semen Hyoscyami, Fructus Tribuli, Radix Aconiti, Flos Caryophylli, Cortex Moutan, the Cortex Eucommiae, Semen Trigonellae, Flos Lonicerae adding distil water are boiled and extract 3 times, add first 6-10 and doubly measure distilled water immersion 3-4 hour, heated and boiled is extracted 2-3 hour; Add for the second time 3-5 and doubly measure distilled water heated and boiled extraction 1-2 hour, add for the third time 2-3 and doubly measure distilled water heated and boiled extraction 0.5-1 hour, merge extractive liquid,, filters, and obtains filtrate, is condensed into dry extract standby;
(2) gained dry extract in step (1) being added to volumetric concentration is 90% alcoholic solution, and standing over night extracts supernatant, and the extractum precipitating is standby;
(3) Semen Ziziphi Spinosae is ground into powder, crossed 200 order fine powders, powder is soaked 1 ~ 2 hour, filter, get solution for standby;
(4) by Cortex Albiziae dedust bits, with wine, soak, clean, take out, dry, be crushed into powder, standby;
(5) Rhizoma Atractylodis Macrocephalae, Indigo Naturalis, Radix Aconiti Kusnezoffii, Herba Paederiae, Flos Daturae 5 taste cflushes is clean, microwave drying, pulverizing is 200 orders, adding volumetric concentration is that 75% alcoholic solution extracts 1.5-2 hour in 70-90 ℃ of hot reflux, elimination medicinal residues, are condensed into extractum and save backup;
(6) by step (2) with after the extractum making in step (5) mixes again and the solution of step (3) gained mix with the powder of step (4) gained, described anesthesia Chinese medicine preparation.
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| WO2023187835A1 (en) * | 2022-03-30 | 2023-10-05 | Hareendran Nair J | A polyherbal local anaesthetic formulation and a method of preparation |
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