CN102772640A

CN102772640A - Medicine for treating asthma and preparation method thereof

Info

Publication number: CN102772640A
Application number: CN2012102946593A
Authority: CN
Inventors: 孙凤梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-20
Filing date: 2012-08-20
Publication date: 2012-11-14
Anticipated expiration: 2032-08-20
Also published as: CN102772640B

Abstract

The invention discloses a medicine for treating asthma and a preparation method thereof. The medicine is mainly prepared from bulbus fritillariae cirrhosae, cinnamon, ephedra, rehmannia glutinosa, antler glue, plantain seed, semen brassicae and salvia miltiorrhiza according to a certain ratio. The medicine has the efficacies of warming lung for dispelling cold, resolving phlegm and removing blood stasis, relieving cough and asthma, and tonifying kidney and holding qi, and has such advantages in treating asthma as rapidness in taking effect, short treatment course and low possibility of relapse.

Description

A kind of medicine of treating asthma and preparation method thereof

Technical field

The present invention relates to a kind of medicine of treating asthma and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Asthma is the air flue chronic inflammation disease of being participated in by various kinds of cell and cellular component.With ictally pant, out of breath, uncomfortable in chest, cough is clinical manifestation, have night with (or) outbreak in early morning and the characteristic that increases the weight of.Asthma is a kind of commonly encountered diseases, frequently-occurring disease.At present, about 300,000,000 people of global asthmatic patient, Chinese asthmatic patient about 3,000 ten thousand.Asthma is to influence the able-bodied important diseases of people.Treat untimelyly, lack of standardization, asthma maybe be fatal.At present, because Western medicine can't effectively be treated asthma, and has certain side effect, therefore, there is very big demand in people to the Chinese medicine of effective treatment asthma.

Summary of the invention

The inventor has found the medicine of effective treatment asthma finally, thereby has accomplished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

The object of the invention just provides a kind of composition of medicine that can treat asthma.

Another object of the present invention has just provided the method for preparing of this composition of medicine.

Medicine of the present invention selects Bulbus Fritillariae Cirrhosae, Radix Et Rhizoma Rhei, windproof, Cortex Cinnamomi, Herba Ephedrae, Radix Rehmanniae Preparata, Colla cornus cervi, Semen Armeniacae Amarum, Semen Plantaginis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Asari, Fructus Perillae, Semen Sinapis Albae and Radix Salviae Miltiorrhizae medicine to make up; Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of asthma.Wherein selecting Bulbus Fritillariae Cirrhosae for use is that lung meridian is gone in cold, and the lung moistening eliminating stagnation is arranged because of its property bitter but sweet flavor, and antitussive expectorant function is controlled cough due to consumptive disease, the spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select for use Radix Et Rhizoma Rhei to be because its nature and flavor are bitter, cold, go into stomach, large intestine, liver footpath, the poison of purging heat is arranged, removing mass stagnates, and the function of clots absorbing blood is controlled the excess-heat constipation; Delirium is gone mad, the food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen; The time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood epistaxis, YANG jaundice, edema; Stranguria with turbid discharge, it is red to urinate, carbuncle and ulcer toxic swelling, furuncle, burn.Selecting for use windproof is that temperature is gone into bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and wins and wets, and the analgesic function is controlled affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.Selecting Cortex Cinnamomi for use is that heat is gone into kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, the complement sun is arranged, warming the spleen and stomach, removing accumulated cold; The function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass; Chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select for use Herba Ephedrae to be because its nature and flavor are arduous, temperature is gone into lung, urinary bladder channel, and diaphoresis is arranged, and relievings asthma; The function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Selecting Colla cornus cervi for use is that temperature is gone into liver, kidney channel because of its property sweet-salty, enriches blood, and the function that benefit is smart is controlled deficiency of kidney-QI, asthenia weakness and emaciation, lumbago, carbuncle of yin nature, impotence in male, spermatorrhea, women's deficiency-cold of uterus, metrorrhagia, leukorrhagia.Select for use Semen Armeniacae Amarum to be because its nature and flavor are bitter, temperature, poisonous, go into lung, large intestine channel, expelling phlegm for arresting cough is arranged, to relieving asthma, the function of intestine moistening is controlled the exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Select for use Semen Plantaginis to be because its nature and flavor are sweet, cold, go into kidney, urinary bladder channel, diuretic is arranged, heat clearing away makes eye bright, and the expectorant function is controlled urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select for use Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature is gone into lung, kidney channel, astringes the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission is controlled the deficiency of the lung and breathed with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select for use the Rhizoma Pinelliae to be because its nature and flavor are hot, temperature, poisonous, go into spleen, stomach warp, drying dampness to eliminate phlegm is arranged, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass is controlled the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Select for use Herba Asari to be because its nature and flavor are hot, temperature is gone into lung, kidney channel, dispel the wind, and cold expelling, row water is opened the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select for use Fructus Perillae to be because its nature and flavor are hot, temperature is gone into lung, large intestine channel, and the therapeutic method to keep the adverse QI flowing downwards is arranged, expectorant, and lung moistening, the function of wide intestinal is controlled cough with dyspnea, phlegm dyspnea, the stagnation of QI, constipation.Select for use Semen Sinapis Albae to be because its nature and flavor are hot, temperature is gone into lung, stomach warp, and the promoting the circulation of QI eliminating phlegm is arranged, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain is controlled the phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, the regurgitation vomiting, aphasia due to apoplexy, the limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select for use Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor is gone into the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, and evacuation of pus, the analgesic function is controlled angina cordis, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.

The specific embodiment

The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and each consumption that divides into groups all has better curative effect in following weight range

Bulbus Fritillariae Cirrhosae 5-15 gram Radix Et Rhizoma Rhei 6-10 restrains windproof 10-20 gram

Cortex Cinnamomi 15-25 gram Herba Ephedrae 5-15 gram Radix Rehmanniae Preparata 11-15 gram

Colla cornus cervi 5-15 gram Semen Armeniacae Amarum 6-10 gram Semen Plantaginis 10-20 gram

Fructus Schisandrae Chinensis 6-10 gram Rhizoma Pinelliae 5-15 gram Herba Asari 10-20 gram

Fructus Perillae 15-25 gram Semen Sinapis Albae 11-15 gram Radix Salviae Miltiorrhizae 5-15 gram

Wherein, be preferably

Windproof 15 grams of Bulbus Fritillariae Cirrhosae 10 gram Radix Et Rhizoma Rhei 8 grams

Cortex Cinnamomi 20 gram Herba Ephedraes 10 gram Radix Rehmanniaes Preparata 13 grams

Colla cornus cervi 10 gram Semen Armeniacae Amarums 8 gram Semen Plantaginiss 15 grams

The Fructus Schisandrae Chinensis 8 gram Rhizoma Pinelliaes 10 gram Herba Asaris 15 grams

Fructus Perillae 20 gram Semen Sinapis Albaes 13 gram Radix Salviae Miltiorrhizaes 10 grams

The method for preparing of medicine of the present invention is following

One, gets the raw materials ready

1, Bulbus Fritillariae Cirrhosae: choose decontamination, water steeps slightly, pulls out, and moistening is peelled off the heart, dries;

2, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

3, windproof: as to remove residual stem, be soaked in water, pull out, run through section, dry;

4, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

5, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;

6, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;

7, Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces;

8, Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

9, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

10, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put to steam in the food steamer and pass through, taking-up is dried;

11, the Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

12, Herba Asari: Ex-all impurity, water spray profit, cutting is in time dried;

13, Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;

14, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance promptly to get;

15, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry.

Two, preparation

1, with the Bulbus Fritillariae Cirrhosae of said weight, Radix Et Rhizoma Rhei, windproof, Cortex Cinnamomi, Herba Ephedrae, Radix Rehmanniae Preparata, Colla cornus cervi, Semen Armeniacae Amarum, Semen Plantaginis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Asari, Fructus Perillae, Semen Sinapis Albae, Radix Salviae Miltiorrhizae decocte with water; Add for the first time 4 times of amounts of water; Soaked 120 minutes; Intense fire decocts boiling, reuse slow fire boiling 20 minutes, time decoction liquor of promptly winning.

2, will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly got decoction liquor for the second time in 15 minutes.

3, twice decoction liquor mixed, reuse slow fire boiling 20 minutes will be boiled liquid and is divided into 6 doses and get final product.

Medicine of the present invention has warming lung for dispelling cold, dissipating phlegm and removing blood stasis, and relieving cough and asthma, the effect of improving inspiration by invigorating the kidney, treatment asthma instant effect, short treating period do not recur.

Below come further to set forth the beneficial effect of medicine of the present invention, these tests to comprise that the animal toxicity test of medicine of the present invention and clinical observation test through Test Example.

The animal toxicity test report of [Test Example 1] medicine of the present invention:

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 40ml/kg, and normal amount is 20ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [Test Example 2] medicine of the present invention:

1, physical data:

Accept out-patient's 140 examples for medical treatment, male patient's 100 examples wherein, female patient 40 examples.

2, diagnostic criteria:

The common sympton of asthmatic patient be paroxysmally pant, symptom such as out of breath, uncomfortable in chest or cough; Small number of patients also possibly be main performance with the chest pain; These symptoms contact outbreak after irritative gas such as smog, perfume, paint, dust, house pet, pollen or the allergen through the patient that is everlasting, night with (or) early morning symptom also take place easily or aggravation.A lot of the patient own audible and the sounds of stridulating when asthma attack.

3, Therapeutic Method

Select above-mentioned medicament for use, take to the patient, take 1 dose at every turn, every day is early, middle and late respectively obeys 1 time, and 20 days is a course of treatment, takes two courses of treatment continuously.

4, efficacy assessment standard

Produce effects: treatment back clinical symptom disappearance, it is normal that body constitution is recovered, and observes and do not have the recidivist half a year;

Take a turn for the better: clinical symptoms is obviously improved, and body constitution is progressively recovered;

Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy asthmatic patient 140 examples of the present invention, produce effects 134 examples as a result, obvious effective rate is 95.71%, 4 examples that take a turn for the better, improvement rate is 2.86%, invalid 2 examples, total effective rate is 98.57%.

Claims

1. medicine of treating asthma, it is characterized in that: it is to be processed by the crude drug in the following weight scope:

Fructus Perillae 15-25 gram Semen Sinapis Albae 11-15 gram Radix Salviae Miltiorrhizae 5-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Fructus Perillae 20 gram Semen Sinapis Albaes 13 gram Radix Salviae Miltiorrhizaes 10 grams.

3. according to the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Bulbus Fritillariae Cirrhosae: choose decontamination, water steeps slightly, pulls out, and moistening is peelled off the heart, dries;

(2) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;

(3) windproof: as to remove residual stem, be soaked in water, pull out, run through section, dry;

(4) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes, or scrapes off rough bark, and with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

(5) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, little profit back cutting is drying to obtain;

(6) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata to get final product;

(7) Colla cornus cervi: get crude drug, remove impurity, the time spent smashs to pieces;

(8) Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

(9) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

(10) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put to steam in the food steamer and pass through, taking-up is dried;

(11) Rhizoma Pinelliae: choose decontamination, sieve dedust bits;

(12) Herba Asari: Ex-all impurity, water spray profit, cutting is in time dried;

(13) Fructus Perillae: the dedust of winnowing with a dustpan bits, clean, dry;

(14) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, little have fragrance promptly to get;

(15) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry;

(2) preparation

(1) with the Bulbus Fritillariae Cirrhosae of said weight, Radix Et Rhizoma Rhei, windproof, Cortex Cinnamomi, Herba Ephedrae, Radix Rehmanniae Preparata, Colla cornus cervi, Semen Armeniacae Amarum, Semen Plantaginis, Fructus Schisandrae Chinensis, the Rhizoma Pinelliae, Herba Asari, Fructus Perillae, Semen Sinapis Albae, Radix Salviae Miltiorrhizae decocte with water; Add for the first time 4 times of amounts of water; Soaked 120 minutes; Intense fire decocts boiling, reuse slow fire boiling 20 minutes, time decoction liquor of promptly winning;

(2) will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly got decoction liquor for the second time in 15 minutes;

(3) twice decoction liquor mixed, reuse slow fire boiling 20 minutes will be boiled liquid and is divided into 6 doses and get final product.