CN104524386A

CN104524386A - Traditional Chinese medicine composition for preventing and treating tuberculosis and preparation method of traditional Chinese medicine composition

Info

Publication number: CN104524386A
Application number: CN201510030895.8A
Authority: CN
Inventors: 陈为坤
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-22
Filing date: 2015-01-22
Publication date: 2015-04-22

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating tuberculosis. The traditional Chinese medicine composition is prepared from the following raw materials by certain weight ratios: radix glehniae, radix ophiopogonis, asparagus cochinchinensis, schisandra chinensis, calamitas urinae hominis, radix stemonae, bletilla striata, rhizoma picrorhizae, dried rehmannia root, raw rhizoma atractylodis macrocephalae, raw oyster shell, artemisia apiacea, turtle shell, starwort root, cortex lycii radicis, blighted wheat, crude dragon bone, rhizoma imperatae, rhizoma nelumbinis, cacumen biotae, common cephalanoplos herb, rhizoma phragmitis and raw liquorice. The traditional Chinese medicine composition has the effects of moistening the lung, nourishing yin, tonifying the stomach, promoting fluid, tonifying the kidneys and calming the heart, and is capable of effectively preventing and treating tuberculosis.

Description

A kind of Chinese medicine composition for tuberculosis prevention and treatment and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for tuberculosis prevention and treatment.The invention still further relates to the preparation method of this Chinese medicine composition.

Background technology

Tuberculosis is a kind of chronic infectious disease of serious harm people ' s health, and by mycobacteria, (mainly mycobacterium tuberculosis (Mycobacterium tuberculosis), causes also known as " tubercule bacillus " (tubercle bacillus).Tuberculosis usually infects and destroys lung and (claims " pulmonary tuberculosis ", also known as " pulmonary tuberculosis " or be called " spitting of blood sick ") and lymphsystem (claim " Tuberculous lymphadenopathy ", also known as " lymphoid tuberculosis "), but other organ as brain, central nervous system, blood circulation, urinary system, skeleton, joint, even skin also can infected (as infect brain can cause " tuberculous meningitis ").China's tuberculosis number of patients occupies second place of the world, is only second to India.Tuberculosis is one of major disease of China's priority control.Tuberculosis is the highest with juvenile onset rate, and according to statistics, the whole world about has 1,700,000,000 people to infect tuberculosis, every year dead 3,000,000 people, and therefore tuberculosis becomes " the second cancer " by a lot of people.Tubercule bacillus passes through respiratory tract infection, attack pulmonary at first, when Abwehrkraft des Koepers reduction to be easy to cause the inflammatory infiltration sexually transmitted disease (STD) of lungs to become, clinical manifestation weight lungy differs, and common are local and the General Symptomies such as cough, expectoration, hemoptysis, chest pain, heating, weak, loss of appetite.

China's Traditional Chinese Medicine claims pulmonary tuberculosis be pulmonary tuberculosis, it thinks that the pathogenesis of pulmonary tuberculosis is divided into endogenous cause of ill and exopathogenic factor two kinds, and exopathogenic factor refers to infected by tuberculomyces, and the invasion of consumptive disease worm is for suffering from, and endogenous cause of ill refers to that natural endowment is not enough, and lose the day after tomorrow in taking good care of, positive QI-insufficiency, resistance against diseases is poor.The sick position of pulmonary tuberculosis is at lung, and pathogenesis character is mainly the deficiency of YIN, and pathological changes impact is overall, pass and spleen, kidney etc. dirty, therefore have saying of " its heresy tossing about in bed, and takes into the five internal organs ".

Current modern medicine is used for the treatment of lungy mainly based on Western medicine, as rifampicin, streptomycin etc., these medicines not only have many side effect, and along with long-term and irrational adaptation, the drug resistance of tulase also can be more and more higher, many patients are by the tubercle bacillus affection of drug resistance, and common drug is without any therapeutic effect.The traditional Chinese medical science is said, prevention of diseae, preventing exacerbation after being taken ill, be therefore also very important in control lungy.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has control for treatment tuberculosis and takes into account, and successful is cheap, easy to use, the feature had no side effect.

Another object of the present invention is to provide the preparation method of this control Chinese medicine composition lungy.

Inventor is in clinical treatment practice for many years, observe the misery that tuberculosis is brought to patient, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula of the Chinese medicine composition for tuberculosis prevention and treatment repeatedly, the present invention selects Radix Glehniae, Radix Ophiopogonis, Radix Asparagi, Fructus Schisandrae Chinensis, calamitas urinae hominis, the Radix Stemonae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Picrorhizae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Concha Ostreae, Herba Artemisiae Annuae, Carapax Trionycis, Radix Stellariae, Cortex Lycii, Fructus Tritici Levis, Os Draconis, Rhizoma Imperatae, Nodus Nelumbinis Rhizomatis, Cacumen Platycladi, Herba Cirsii, Rhizoma Phragmitis, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is nourishing lung-YIN, reinforcing stomach reg fluid, effect of kidney calming, thus effectively can prevent and treat tuberculosis.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Glehniae: be the dry root of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq..Nature and flavor: sweet, micro-hardship, to be slightly cold.Return lung, kidney channel.Effect: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Research display: Radix Glehniae not only has the effect of antipyretic-antalgic, can also strengthen body immunity.

Radix Ophiopogonis: be the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogon japonicus (Thunb.) Ker-Gawl..Nature and flavor: sweet, micro-hardship, to be slightly cold.GUIXIN, lung, stomach warp.Effect: reinforcing stomach reg fluid, nourishing lung-YIN, clear away heart-fire relieving restlessness.Radix Ophiopogonis can clear away heart-fire in yin nourishing, and relieving restlessness is calmed the nerves.The heart-nutriment, fever aggravated at night is entered with controlling warm febrile disease.Normal and Herba Dendrobii matches.

Radix Asparagi: be the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor: sweet, bitter, cold.Return lung, kidney channel.Effect: nourishing YIN to relieve dryness, lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.Radix Asparagi and Radix Ophiopogonis often use simultaneously, to strengthen nourishing lung-YIN, the effect of the relieving restlessness that clears away heart-fire.

Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Calamitas urinae hominis: this product is thin slice or the block sheet of the canescence amorphism condensed in wooden pail for urine or urine cylinder, and clean dry forms.Nature and flavor: salty, cold.Enter liver, three burnt, urinary bladder channels.Effect: heat-clearing and toxic substances removing, hemostasis by removing blood stasis.For laryngopharynx swelling and pain, ulcerative gingivitis aphtha, the diseases such as spitting of blood, epistaxis.To diseases such as the spitting of blood caused by heat in blood, epistaxis, the blood-cooling hemostatics such as Cacumen Platycladi, Radix Cirsii Japonici, Herba Cirsii, charred Nodus Nelumbinis Rhizomatis can be coordinated with using." Japan hanako materia medica ": control consumptive fever, consumptive lung disease, heart heat of the diaphragm, serious epistaxis is spitted blood, thin thirsty disease.

The Radix Stemonae: be the dried root of Stemonaceae plant Radix Stemonae Stemona sessilifolia (Miq.) Miq., Radix stemonae japonicae Stemona japonica (Bl.) Miq. or radix stemonae tuberosae Stemona tuberosa Lour..Nature and flavor: sweet, bitter, tepor.Return lung meridian.Slightly poisonous.Effect: nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outer for head louse, body louse, enterobiasis, pudendal pruritus.Research shows that Radix stemonae japonicae infusion is in vitro to various pathogens, and some pathomycete has certain inhibitory action, and the Radix Stemonae also has the effect of external parasite killing in addition.

The Pseudobulbus Bletillae (Rhizoma Bletillae): be the orchid family herbaceos perennial Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata(Thunb.) dry tuber of Reichb. f..Nature and flavor: pungent, bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach warp.Effect: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Modern pharmacology research shows: it is active that the Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, has anastalsis to local hemorrhage; Zoopery shows, external haemostatic effect is quite good to substantial organ (liver, spleen), muscle vascular be hemorrhage etc. for Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.Had record in " book on Chinese herbal medicine is looked for the truth ": Pseudobulbus Bletillae (Rhizoma Bletillae), square book both carried function and had entered lung hemostasis, and carry again can control to fall and flutter folding bone, soup fire is burnt, malignant boil carbuncle, loses the dead flesh of cellulitis, obtained non-like receiving, like puckery, like only more than? do not know book speech function hemostasis person, be because of the puckery meaning of property also; Book speech can be controlled carbuncle and damages the wounded, be because of acrid in the mouth can be loose meaning also.Have loose during this medicine is puckery, invigorating middle warmer has broken, therefore book carries again removing the necrotic tissue, removing blood stasis, tissue regeneration promoting.

Rhizoma Picrorhizae: be the dry rhizome of goatweed Rhizoma Picrorhizae Picrorhiza scrophulariiflora Pennell.Nature and flavor: bitter, cold.Return liver, stomach, large intestine channel.Effect: clearing away damp-heat, except hectic fever due to YIN-deficiency, disappear infantile malnutrition with fever.For damp-heat dysentery, jaundice, haemorrhoids, osteopyrexia and fever, children's's infantile malnutrition with fever.The compatibilities such as this product and the Rhizoma Anemarrhenae, Herba Artemisiae Annuae, Cortex Lycii, Radix Stellariae, Radix Gentianae Macrophyllae, Carapax Trionycis, can control fever due to yin deficiency, hectic fever in the afternoon." Bencao Jingshu ": Rhizoma Picrorhizae, kind in damp and hot, therefore main chronic dysentery becomes infantile malnutrition and cold and hotly lets out dysentery, thick the intestines and stomach.Typhoid cough person, pathogenic heat are lunar at hands, foot sun is also bright.Pyrexial malaria hectic fever due to YIN-deficiency person, heat between bone also.Reason waist kidney, the person that goes to polyhidrosis around the external genitals, suffer from a deficiency of the kidney damp and hot dirty visitor it, to make between heat volt kidney also.Pediatric epilepsy scared, cold and heat, do not descend trencherman, heat is raw wind then, therefore send out infantile convulsion, and heat is in appetite, therefore lower food also.The main five colors of the heart, the main muscle of taste, two go through damp and hot, then color is from also good.Three disappear five hemorrhoid, adult's dysphoria with feverish sensation in the chest palms and soles person, nothing but damp and hot the intestines and stomach and fire between the five internal organs also.Great Cold, extremely clear property, can heat clearing away to bitter, and from the intestines and stomach with inferior to bone, all damp and hot, pathogenic heat, cloudy point of latent heat institute is sick all, there's no one who doesn't or isn't eliminates.

Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Nature and flavor: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Can be used for Tianjin wound thirsty, interior-heat is quenched one's thirst.This product is sweet cold, can among heat clearing away YIN nourishing and the production of body fluid promoting, cold in nature and enter blood system, can not only the heat of clearing heat in YING system blood system and removing heat from blood, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the effect of nourishing YIN and clearing away heat, is often equal to Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae) and uses.

Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, the Rhizoma Atractylodis Macrocephalae can air making-up and spleen enlivening, again can dampness diuretic, is the key medicine of the spleen strengthening and damp drying.In the sweet temperature compensation of the Rhizoma Atractylodis Macrocephalae, can air making-up and spleen enlivening, also can strengthening superficial resistance to stop perspiration, and Radix Astragali compatibility, play the merit of spleen reinforcing lung altogether.To rule together asthenia, the weak person of overstrain.Rhizoma Atractylodis Macrocephalae antibacterial action is obvious: infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.

Concha Ostreae: be the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Grosse or Crassostrea rivularis Ostrea rivularis Gould etc.Nature and flavor: salty, be slightly cold.Return liver, gallbladder, kidney channel.Effect: suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, convergence are astringent or styptic treatment for spontaneous sweating.Research shows: Concha Ostreae is also containing vitamin B12, and this is that general food lacked, and the brill element in vitamin B12 is the indispensable material of prevention pernicious anemia, and thus Concha Ostreae has again the effect enlivening hemopoietic function.Concha Ostreae salty in the mouth, hard masses softening and resolving.By sucutaneous nodule, the scrofula of controlling phlegm-fire pent-up.

Herba Artemisiae Annuae: be the dry aerial parts of feverfew Herba Artemisiae annuae Artemisia annua L..Nature and flavor: bitter, acrid, cold.Return liver, gallbladder meridian.Effect: clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.Herba Artemisiae Annuae water logging agent (1:3) is in vitro to some inhibitory action of some dermatophytes.Its ethanol extraction is in vitro 7.8 mg/ml to leptospiral antimicrobial concentration, and effect and Fructus Forsythiae, Cortex Phellodendri, Rhizoma Paridis are similar.Record in " book on Chinese herbal medicine newly organized ": Herba Artemisiae Annuae, specially separate hectic fever due to YIN-deficiency consumptive fever, especially can let out the fire of summer-heat, let out and intimately and not consume QI and blood, the medicine to help QI and blood of use, makes outstanding contributions greatly, can monarch can minister, and can help and can make, should not be also.But must be multiplex, because its body is both light, and property is held concurrently nourishing YIN, few with turning incapable.

Carapax Trionycis: be the carapace of Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis Wiegmann.Nature and flavor: salty, are slightly cold.Return liver, kidney channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.Radix Stellariae compatibility Carapax Trionycis Radix Stellariae is sweet cold, clearing away heat and cooling blood, reducing the asthenic fever, except hectic fever due to YIN-deficiency; Carapax Trionycis is salty-cold, nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming. Papillary, and play replenishing YIN and removing heat altogether except effect of steaming, be used for the treatment of fever due to yin deficiency, hectic fever due to YIN-deficiency, infantile malnutrition; Or the calentura later stage, waste heat not to the greatest extent person.

Radix Stellariae: be the dry root of Caryophyllaceae Stellaria plant Radix Stellariae Stellaria dichotoma L. var.lanceolata Bge..Nature and flavor: sweet, be slightly cold.Return liver, stomach warp.Effect: clearind deficient heat, dispelling fever with infantile malnutrition.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, children's's infantile malnutrition with fever.The sweet cold tonifying YIN of these product, clearing away heat and cooling blood, brings down a fever and not bitterly to let out, the cloudy and not ascension of reason, and for reducing the asthenic fever is except the common medicine of hectic fever due to YIN-deficiency, normal medicine is same with Herba Artemisiae Annuae, Cortex Lycii, Carapax Trionycis etc. uses.Radix Stellariae not only has the effect of heat clearing away, also has the effect of removing heat from blood concurrently.Radix Stellariae compatibility Carapax Trionycis, Radix Stellariae is sweet cold, clearing away heat and cooling blood, reducing the asthenic fever, except hectic fever due to YIN-deficiency; Carapax Trionycis is salty-cold, nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming. Papillary, play replenishing YIN and removing heat altogether except effect of steaming.

Cortex Lycii: be the dry root bark of matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum L..Nature and flavor: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.Record in " book on Chinese herbal medicine is stated ": cure mainly deficient fever, alternate attacks of chills and fever, allly see blood disorder, epistaxis, cough blood, cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine.

Fructus Tritici Levis: be the shrivelled frivolous caryopsis of grass Semen Tritici aestivi.Nature and flavor: sweet, salty, cool.GUIXIN, kidney channel.Function cures mainly: control hectic fever due to YIN-deficiency consumptive fever, only spontaneous sweating.Radix Astragali closes Fructus Tritici Levis, is the conventional to medicine for the treatment of spontaneous sweating due to deficiency of QI.Should be used for the treatment of all asthenia damage, defend gas lose solid, interspaces of skin and muscles being loose from sweating syndrome, deficiency of vital energy person is belonged to for night sweat, can select again.

Os Draconis: Os Draconis be ancient times mammal as if the Skeletal Fossils of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor: sweet, puckery are flat.Enter the heart, liver, kidney, large intestine channel.Effect: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.Os Draconis matter weight, has the effect of good tranquillizing the mind by relieving convulsion, and available to control various mind uneasy, insomnia and dreamful sleep, tinnitus etc.

Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

Nodus Nelumbinis Rhizomatis: be the loose rhizome of nymphaeaceae plant lotus Nelumbo nucifera G..Nature and flavor: flat, sweet, puckery.Gui Jing: stomach, liver, kidney.Effect: hemostasis, dissipating blood stasis.Control hemoptysis, spit blood, epistaxis, hematuria, has blood in stool, dysentery, metrorrhagia.All pulmonary tuberculosis spitting of blood persons, can with Pseudobulbus Bletillae (Rhizoma Bletillae) compatibility, with hemostasis of astringing the lung.The sweet adstringency of this product is put down, can astringing to arrest bleeding, again can dissipating blood stasis blood, and have the advantages that the stasis of blood is not stayed in hemostasis, only the efficacy of a drug is more slow, is often used as to assist hemorrhage.The joint portion of Rhizoma Nelumbinis.For epistaxis, hemoptysis, spit blood, have blood in stool, hematuria and woman uterine bleeding, person is the most suitable to have blood stasis to lose blood.Alone, or the medicine that compatibility is suitable.

Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor: bitter, puckery, cold.Return lung, liver, spleen channel.Effect: cooling blood for hemostasis, growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.Cacumen Platycladi bitter in the mouth cold in nature, energy cooling blood for hemostasis, experimental study has the effect of certain anti-inflammation.

Herba Cirsii: be the dry aerial parts (wounded in the battle herb) of Compositae field thistle platymiscium field thistle Cephalanoplos segetum (Bunge) Kitam. [Cirsium segetum Bunge], root stock also can be used as medicine.Nature and flavor: sweet, bitter, cold.GUIXIN, Liver Channel.Effect: herb: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.Root stock: hepatitis." Records of Tradition Chinese and Western Medicine in Combination ": fresh Herba Cirsii root, cool in naturely makes moist, and is apt to into blood system, the heat to purify the blood most point, all hemoptysis, haematemesis, epistaxis, two just hematochezia because of hot person, take there's no one who doesn't or isn't vertical.Kindly again control pneumonopathy tuberculosis, no matter what, use all suitable phase, namely alonely also can to prove effective.And control the swollen pain of all skin infection, flower willow poison drenches, the puckery pain of hematochezia.Covering its property not only can cooling blood for hemostasis, and holding concurrently can promoting blood circulation and detoxication, is have above all effects also.The property of its cool profit, kind nourishing YIN and benefiting blood, controls fever due to deficiency of blood again.To female in metrorrhagia leucorrhea with bloody discharge, its because of hot person with also imitate.

Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Rhizoma Phragmitis one medicine, is mainly used in following two aspects clinically, can clearing away lung-heat and evacuation of pus of eliminating the phlegm, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Radix Glehniae nourishing YIN and clearing away lung-heat in side, reinforcing stomach reg fluid, Radix Ophiopogonis, Radix Asparagi reinforcing stomach reg fluid, nourishing lung-YIN, astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of Fructus Schisandrae Chinensis convergence, above four tastes are monarch drug altogether, tubercule bacillus attacks the pulmonary of people at first, and expense is tender dirty, therefore monarch drug fundamentally carries out nourishing lung-YIN, kidney calming from health, and function of spleen and stomach regulating, increase the resistance of patient, the spleen being the foundation of acquired constitution, spleen is strong, and then the five internal organs are foster to some extent, and health is naturally healthy.Calamitas urinae hominis's heat-clearing and toxic substances removing, hemostasis by removing blood stasis, Radix Stemonae nourishing the lung to arrest cough, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, Rhizoma Picrorhizae clearing away damp-heat, dispelling fever with infantile malnutrition, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, Concha Ostreae suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, above seven tastes are ministerial drug altogether, increase effect of monarch drug nourishing lung-YIN, reinforcing stomach reg fluid, also have clearing away heat and cooling blood simultaneously, invigorating the spleen and benefiting QI, effect of hard masses softening and resolving, is used for eliminating sucutaneous nodule, to alleviate the complication such as cough, spitting of blood that tuberculosis is brought.Herba Artemisiae Annuae removing damp-heat, Carapax Trionycis hard masses softening and resolving, Radix Stellariae clearind deficient heat, dispelling fever with infantile malnutrition, Cortex Lycii lung heat clearing pathogenic fire reducing, Fructus Tritici Levis removing heat from blood is except steaming, Os Draconis tranquillizing and allaying excitement, arresting sweating controlling nocturnal emission with astringent drugs, Rhizoma Imperatae cooling blood for hemostasis, Nodus Nelumbinis Rhizomatis dissipating blood stasis stops blooding, Cacumen Platycladi, Herba Cirsii cooling blood for hemostasis, removing blood stasis to reduce swelling, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, above a few taste is adjuvant drug altogether, also has clearing away the hectic fever while assisting a ruler in governing a country monarch drug ministerial drug, effect of cooling blood for hemostasis, increase the resistance of patient, scholar supports patient's the five internal organs, thus reaches the effect taken into account tuberculosis prevention and treatment, Radix Glycyrrhizae priming is returned through, coordinating the actions of various ingredients in a prescription, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of nourishing lung-YIN, reinforcing stomach reg fluid, kidney calming, effectively can treat tuberculosis prevention and treatment.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Glehniae 10-20 part, Radix Ophiopogonis 7-17 part, Radix Asparagi 7-17 part, Fructus Schisandrae Chinensis 7-17 part, calamitas urinae hominis 3-9 part, Radix Stemonae 7-17 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Rhizoma Picrorhizae 7-17 part, Radix Rehmanniae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Concha Ostreae 15-25 part, Herba Artemisiae Annuae 13-23 part, Carapax Trionycis 7-17 part, Radix Stellariae 7-17 part, Cortex Lycii 10-20 part, Fructus Tritici Levis 15-25 part, Os Draconis 15-25 part, Rhizoma Imperatae 10-20 part, Nodus Nelumbinis Rhizomatis 7-17 part, Cacumen Platycladi 4-14 part, Herba Cirsii 5-15 part, Rhizoma Phragmitis 13-23 part, Radix Glycyrrhizae 3-9 part.

Wherein be preferably: Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Asparagi 12 parts, Fructus Schisandrae Chinensis 12 parts, calamitas urinae hominis 6 parts, the Radix Stemonae 12 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Rhizoma Picrorhizae 12 parts, Radix Rehmanniae 15 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Concha Ostreae 20 parts, Herba Artemisiae Annuae 18 parts, Carapax Trionycis 12 parts, Radix Stellariae 12 parts, Cortex Lycii 15 parts, Fructus Tritici Levis 20 parts, Os Draconis 20 parts, Rhizoma Imperatae 15 parts, Nodus Nelumbinis Rhizomatis 12 parts, Cacumen Platycladi 9 parts, Herba Cirsii 10 parts, Rhizoma Phragmitis 18 parts, Radix Glycyrrhizae 6 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine composition to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is granule, and its preparation method is as follows:

Step one: according to weight proportion of the present invention, becomes medicated bag by Fructus Schisandrae Chinensis, Fructus Tritici Levis bundle, is put in water and soaks about 45 minutes, filters, for subsequent use;

Step 2: by weight proportion of the present invention, takes calamitas urinae hominis's pulverizing and is ground to 180 mesh sieves, for subsequent use;

Step 3: by weight proportion of the present invention, take Concha Ostreae, Carapax Trionycis, Os Draconis is suitably pulverized, bind up with gauze, put into after marmite adds step one immersion and remain cold water, exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Radix Glehniae is added, Radix Ophiopogonis, Radix Asparagi, the Radix Stemonae, Rhizoma Picrorhizae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Stellariae, Cortex Lycii, Rhizoma Imperatae, Nodus Nelumbinis Rhizomatis, Rhizoma Phragmitis is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 ~ 4 li centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, add the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Artemisiae Annuae, Cacumen Platycladi, Herba Cirsii, medicated bag in Radix Glycyrrhizae and step one, decoct 30 minutes, filter, waste, for subsequent use,

Step 4: twice filtrate in step 3 is merged, adds the powder in step 2 while hot, stir, and by about concentration of liquid medicine to 80 DEG C time, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, under 60 DEG C of environment, the thick paste of relative density 1.13 ~ 1.20, dry, pulverize into fine powder, add appropriate Icing Sugar as diluent, ethanol as disintegrating agent, adopts dry granulation as wetting agent and microcrystalline Cellulose, make 15g/ bag, every bag of granule containing crude drug 5g.

Medicine of the present invention has the effects such as nourishing lung-YIN, reinforcing stomach reg fluid, kidney calming, and control takes into account, successful, cheap, easy to use, have no side effect, the mode that this Chinese medicine composition adopts is treated and can be reduced the damage of Western medicine to human liver renal function, alleviates the slight illness of patient.According to clinical 180 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 97.8%.

Detailed description of the invention

Embodiment one, Radix Glehniae 10 parts, Radix Ophiopogonis 7 parts, Radix Asparagi 7 parts, Fructus Schisandrae Chinensis 7 parts, calamitas urinae hominis 3 parts, the Radix Stemonae 7 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Rhizoma Picrorhizae 7 parts, Radix Rehmanniae 10 parts, Rhizoma Atractylodis Macrocephalae 10 parts, Concha Ostreae 15 parts, Herba Artemisiae Annuae 13 parts, Carapax Trionycis 7 parts, Radix Stellariae 7 parts, Cortex Lycii 10 parts, Fructus Tritici Levis 15 parts, Os Draconis 15 parts, Rhizoma Imperatae 10 parts, Nodus Nelumbinis Rhizomatis 7 parts, Cacumen Platycladi 4 parts, Herba Cirsii 5 parts, Rhizoma Phragmitis 13 parts, Radix Glycyrrhizae 3 parts.

Embodiment two, Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Asparagi 12 parts, Fructus Schisandrae Chinensis 12 parts, calamitas urinae hominis 6 parts, the Radix Stemonae 12 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Rhizoma Picrorhizae 12 parts, Radix Rehmanniae 15 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Concha Ostreae 20 parts, Herba Artemisiae Annuae 18 parts, Carapax Trionycis 12 parts, Radix Stellariae 12 parts, Cortex Lycii 15 parts, Fructus Tritici Levis 20 parts, Os Draconis 20 parts, Rhizoma Imperatae 15 parts, Nodus Nelumbinis Rhizomatis 12 parts, Cacumen Platycladi 9 parts, Herba Cirsii 10 parts, Rhizoma Phragmitis 18 parts, Radix Glycyrrhizae 6 parts.

Embodiment three, Radix Glehniae 20 parts, Radix Ophiopogonis 17 parts, Radix Asparagi 17 parts, Fructus Schisandrae Chinensis 17 parts, calamitas urinae hominis 9 parts, the Radix Stemonae 17 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Rhizoma Picrorhizae 17 parts, Radix Rehmanniae 20 parts, Rhizoma Atractylodis Macrocephalae 20 parts, Concha Ostreae 25 parts, Herba Artemisiae Annuae 23 parts, Carapax Trionycis 17 parts, Radix Stellariae 17 parts, Cortex Lycii 20 parts, Fructus Tritici Levis 25 parts, Os Draconis 25 parts, Rhizoma Imperatae 20 parts, Nodus Nelumbinis Rhizomatis 17 parts, Cacumen Platycladi 14 parts, Herba Cirsii 15 parts, Rhizoma Phragmitis 23 parts, Radix Glycyrrhizae 9 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

In May, 2012 to 2013, year December treatment tuberculosis patient 180 was routine.Wherein male 118 example, women 62 example, M-F 1.9:1, max age 53 years old, minimal ages 19 years old, patient age, sex, etc. every basic document substantially identical, no significant difference (P > 0.05).

Two, Therapeutic Method

Observation group is according to Medications Example two of the present invention, and the granule that preferred preparation method is made, and boiled water is taken after mixing it with water, every day 3 times, each one bag, within 10 days, is a course for the treatment of.

Three, efficacy assessment standard

1, cure: clinical symptoms lungy disappears completely, and the tuberculosis symptom manifested everywhere disappears all completely, place's enlargements such as bone, joint, lymph disappear, and routine urinalysis etc. check normal.

2, take a turn for the better: clinical symptoms lungy is alleviated gradually, and the tuberculosis symptom manifested everywhere is controlled.

3, do not heal: control lungy is without any effect.

Four, therapeutic outcome statistics

According to statistical result showed, Chinese medicine of the present invention has good clinical effectiveness on tuberculosis prevention and treatment, effectively can improve the cure rate for the treatment of, is worth promoting in clinical practice.

Model case and curative effect:

Case one, Ma, female, 41 years old, suffer from lymphoid tuberculosis one month, have the performance at initial stage, patient's Timeliness coverage, come here to go to a doctor, adopt case two method of the present invention, after patient takes a course for the treatment of, sensory symptoms obviously alleviates, continue two courses for the treatment of of use, patient goes to hospital to check, and lymph place tuberculosis symptom disappears completely, recovery from illness.

Case two, Wang, man, 22 years old, have pulmonary tuberculosis patient in patient's readme surrounding population, there is the phenomenon of having a fever, coughing in patient, patient removes examination in hospital recently, because the time is shorter, do not find mycobacterium tuberculosis infection, rear patient comes here, find control tuberculosis, adopt case two method of the present invention, after patient takes a course for the treatment of, sensory symptoms obviously alleviates, and continues a course for the treatment of of use, goes to hospital to check, do not find mycobacterium tuberculosis infection, recovery from illness.

Case three, appoint certain, female, 30 years old, patient suffered from pulmonary tuberculosis, undesirable in hospitalize effect, after take the medicines such as rifampicin again, effect or not obvious, after being introduced.Come here to go to a doctor, adopt case two method of the present invention, after patient takes a course for the treatment of, sensory symptoms obviously alleviates, the symptom of cough, fever disappears substantially, and continue a course for the treatment of of use, symptom disappears completely, and Working Life is all normal, go to hospital to check, every inspection is normal, recovery from illness.

Claims

1. the Chinese medicine composition for tuberculosis prevention and treatment, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Radix Glehniae 10-20 part, Radix Ophiopogonis 7-17 part, Radix Asparagi 7-17 part, Fructus Schisandrae Chinensis 7-17 part, calamitas urinae hominis 3-9 part, Radix Stemonae 7-17 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Rhizoma Picrorhizae 7-17 part, Radix Rehmanniae 10-20 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Concha Ostreae 15-25 part, Herba Artemisiae Annuae 13-23 part, Carapax Trionycis 7-17 part, Radix Stellariae 7-17 part, Cortex Lycii 10-20 part, Fructus Tritici Levis 15-25 part, Os Draconis 15-25 part, Rhizoma Imperatae 10-20 part, Nodus Nelumbinis Rhizomatis 7-17 part, Cacumen Platycladi 4-14 part, Herba Cirsii 5-15 part, Rhizoma Phragmitis 13-23 part, Radix Glycyrrhizae 3-9 part.

2. the Chinese medicine composition for tuberculosis prevention and treatment according to claims 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Glehniae 15 parts, Radix Ophiopogonis 12 parts, Radix Asparagi 12 parts, Fructus Schisandrae Chinensis 12 parts, calamitas urinae hominis 6 parts, the Radix Stemonae 12 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Rhizoma Picrorhizae 12 parts, Radix Rehmanniae 15 parts, Rhizoma Atractylodis Macrocephalae 15 parts, Concha Ostreae 20 parts, Herba Artemisiae Annuae 18 parts, Carapax Trionycis 12 parts, Radix Stellariae 12 parts, Cortex Lycii 15 parts, Fructus Tritici Levis 20 parts, Os Draconis 20 parts, Rhizoma Imperatae 15 parts, Nodus Nelumbinis Rhizomatis 12 parts, Cacumen Platycladi 9 parts, Herba Cirsii 10 parts, Rhizoma Phragmitis 18 parts, Radix Glycyrrhizae 6 parts.

3. the Chinese medicine composition for tuberculosis prevention and treatment according to claim 1 and 2, is characterized in that: described Chinese medicine composition is granule.

4. for a preparation method for the Chinese medicine composition of tuberculosis prevention and treatment, it is characterized in that, preparation method is as follows: step one: according to weight proportion of the present invention, and Fructus Schisandrae Chinensis, Fructus Tritici Levis bundle are become medicated bag, is put in water and soaks about 45 minutes, filters, for subsequent use, step 2: by weight proportion of the present invention, takes calamitas urinae hominis's pulverizing and is ground to 180 mesh sieves, for subsequent use, step 3: by weight proportion of the present invention, take Concha Ostreae, Carapax Trionycis, Os Draconis is suitably pulverized, bind up with gauze, put into after marmite adds step one immersion and remain cold water, exceed powder 3 ~ 6 centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 4 cm is added in residue medicinal residues, then Radix Glehniae is added, Radix Ophiopogonis, Radix Asparagi, the Radix Stemonae, Rhizoma Picrorhizae, Radix Rehmanniae, Rhizoma Atractylodis Macrocephalae, Radix Stellariae, Cortex Lycii, Rhizoma Imperatae, Nodus Nelumbinis Rhizomatis, Rhizoma Phragmitis is put into after marmite adds step one immersion and is remained cold water, exceed powder 3 ~ 4 li centimetres, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, the water of 3 cm is added in residue medicinal residues, add the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Artemisiae Annuae, Cacumen Platycladi, Herba Cirsii, medicated bag in Radix Glycyrrhizae and step one, decoct 30 minutes, filter, waste, for subsequent use, step 4: twice filtrate in step 3 is merged, adds the powder in step 2 while hot, stir, and by about concentration of liquid medicine to 80 DEG C time, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, under 60 DEG C of environment, the thick paste of relative density 1.13 ~ 1.20, dry, pulverize into fine powder, add appropriate Icing Sugar as diluent, ethanol as disintegrating agent, adopts dry granulation as wetting agent and microcrystalline Cellulose, make 15g/ bag, every bag of granule containing crude drug 5g.