CN104324083A - Pharmaceutical composition for treating kidney stones and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating kidney stones and preparation method of pharmaceutical composition Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating kidney stones and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: lygodium japonicum, radix cudramiae parasitism, longhairy antenoron herb, plantain herb, parslane herb, herba pyrrosiae, chicken gizzard-membrane and pig kidney. The pharmaceutical composition provided by the invention can effectively treat paroxysmal lumbago accompanied by hematuria and other clinical symptoms caused by the kidney stones.
Description
Technical field
The present invention relates to the field of Chinese medicines for the treatment of, be specifically related to pharmaceutical composition for the treatment of renal calculus and preparation method thereof.
Background technology
Renal calculus is urinary system commonly encountered diseases, frequently-occurring disease, and male's morbidity, more than women, is multiplely born in person between twenty and fifty, the sickness rate no significant difference of left and right sides.The renal calculus patient of 40% ~ 75% has lumbago in various degree.Calculus is comparatively large, and degree of excursion is very little, shows as the swollen discomfort of waist acid, or has dull pain or dull pain when body movement increases.Compared with the angor that microlith causes, often suddenly there is the waist and belly sample that lancinates and have an intense pain, in paroxysmal.
Affect lithogenous factor a lot, age, sex, race, heredity, environmental factors, dietary habit are relevant to the formation of calculus with occupation.The blocking of the Developmental and Metabolic Disorder of body, urinary tract, infect, the use of foreign body and medicine be lithogenous commonly encountered diseases because of.Known that urinary calculi has 32 kinds of compositions, modal composition is calcium oxalate.The calculus of other compositions, as ammoniomagnesium phosphate, uric acid, calcium phosphate and cystine (seed amino acid) etc., also can be the mixture of above various composition.
Position according to calculus can be divided into: upper urinary stone comprises renal calculus, ureteral calculus; Calculus of lower urinary tract comprises vesical calculus, calculus of urethra.
The patient of renal calculus does not have symptom mostly, causes ureteral urine to block unless renal calculus drops to ureter from kidney.Common symptom has waist and belly angor, Nausea and vomiting, dysphoria, abdominal distention, hematuria etc.If merging urinary tract infection, also the phenomenons such as fear of cold heating may be there is.Acute kidney angor often makes patient pain unbearably.
Sometimes patient is painless, only have hematuria or blood volume atomic, naked eyes be can't see.Mostly comprise uroscopy during health check-up, and centrifugal by microscopy urine after sediment, if see that erythrocyte number too much just indicates hematuria, the early stage sign of renal calculus just sometimes.
Therapeutic Method: first answer symptomatic treatment.As analgesic drug product when angor is shown effect, if find concurrent infection or block, should infect by look-ahead as the case may be, row intra-ureteral cannula or renal pelvis fistulation if desired, ensure that urine drainage is unobstructed, in order to infection control, prevent renal function injury.Actively find the cause of disease simultaneously, formulate treatment and prevention scheme according to heterogeneity and the cause of disease, tackle the problem at its root, prevent recurrence of hepatolithiasis as far as possible.
General treatment: (1) great quantity of water drinking (2) relieving spasm to stop pain (3) infection control.
Surgical intervention: pain can not by agents alleviate or calculus diameter larger time, should consider to take surgical intervention measure.Comprising: 1. extracorporeal shock wave lithotripsy.2. placing rack in ureter, can also coordinate ESWL to treat.3. through ureteroscope rubble lithotomy.4. percutaneous nephrolithotomy.5. peritoneoscope Lithotomy.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of renal calculus;
Another object of the present invention is to provide a kind of preparation method for the treatment of the pharmaceutical composition of renal calculus.
The object of the invention is by following technical scheme realize:
The pharmaceutical composition for the treatment of renal calculus of the present invention, it is prepared from by the raw material of following weight portion:
Spora Lygodii 20-40 part, the parasitic 30-50 part of Radix Cudraniae, Herba Lysimachiae 10-30 part, Herba Plantaginis 10-30 part, Herba Portulacae 10-30 part, Folium Pyrrosiae 10-30 part, Endothelium Corneum Gigeriae Galli 8-13 part, Ren sus domestica 50-100 part;
Preferably, be prepared from by the raw material of following weight portion:
Parasitic 40 parts of Spora Lygodii 30 parts, Radix Cudraniae, Herba Lysimachiae 20 parts, Herba Plantaginis 20 parts, Herba Portulacae 20 parts, Folium Pyrrosiae 20 parts, Endothelium Corneum Gigeriae Galli 10 parts, Ren sus domestica 60 parts.
Below crude drug source and the primary efficacy of Chinese medicine preparation of the present invention:
Spora Lygodii: be the drying and ripening spore of Lygodiaceae plant Spora Lygodii Lygodium japonicum (Thunb.) Sw..Tap rattan leaf when autumn, spore did not come off, dry, crumple or lay spore, removing rattan leaf.[nature and flavor with return through] are sweet, salty, cold.Return bladder, small intestine meridian.[function with cure mainly] eliminating damp-heat, treating stranguria pain relieving.For pyretic stranguria, stranguria caused by urinary stone, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.
Radix Cudraniae is parasitic: another name: yellow wood is parasitic, fear sesame is parasitic, make Herba Taxilli, that thorn strangles wood is parasitic.Meridian distribution of property and flavor: sweet, micro-hardship, cool in nature.Enter lung, spleen, liver, kidney channel.Function cures mainly: dissipating blood stasis for subsidence of swelling, promoting the circulation of QI to relieve pain, expelling wind and removing dampness.Control that pulmonary tuberculosis, icterohepatitis, hepatomegaly, rheumatic arthralgia, the traumatic injury stasis of blood are long-pending, puerpera's difficult labour.
Herba Lysimachiae: be the dry herb of Ofthe Primulaceae Lysimachia christinae Hance Lysimachia christinae Hance.Summer, Qiu Erji gather, and removing impurity, dries.[nature and flavor with return through] are sweet, salty, are slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.[function with cure mainly] sting the jaundice eliminating that wets, inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, gallbladder-distention hypochondriac pain, stranguria caused by urinary stone, pyretic stranguria, difficulty and pain in micturition, carbuncle furuncle, snake bite and insect sting.
Herba Plantaginis: be the dry herb of Plantaginaceae plant Herba Plantaginis Plantago asiatica L. or Plantago depressa Willd Plantago depressa Willd..Summer excavates, and removing silt, dries.[nature and flavor with return through] are sweet, cold.Return liver, kidney, lung, small intestine meridian.[function with cure mainly] clearing away heat and promoting diuresis is treating stranguria, eliminates the phlegm, removing heat from blood, removing toxic substances.For the puckery pain of pyretic stranguria, edema oliguria, diarrhea due to summer heat and dampness, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.[usage and consumption] 9 ~ 30g.
Herba Portulacae: be the dry aerial parts of portulacaceous plant Herba Portulacae Portulaca oleracea L..Summer, Qiu Erji gather, removing undesirable root and impurity, clean, and dry after slightly steaming or scalding.[nature and flavor with return through] acid, cold.Return liver, large intestine channel.[function with cure mainly] heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.For toxic-heat and blood stasis, carbuncle treats skin ulcer, and eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
Folium Pyrrosiae: be Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, Folium Pyrrosiae Pyrrosia Lingua (Thunb.) Farwell or pyrrosia petiolosaChing Pyrrosia petiolosa (Christ) Ching sunlight dried leaves.The whole year all can gather, removing rhizome and root, dry or the moon in.[nature and flavor with return through] are sweet, bitter, are slightly cold.Return lung, urinary bladder channel.[function with cure mainly] inducing diuresis for treating stranguria syndrome, clearing away lung-heat to relieve cough, cooling blood for hemostasis.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, drenches the puckery pain of drop, dyspnea and cough due to lung-heat, spits blood, epistaxis, hematuria, metrorrhagia.
Endothelium Corneum Gigeriae Galli: be the dry inner wall of sandbag of Phasianidae animal man chicken Gallus gallus domesticus Brisson.After killing chicken, take out chicken gizzard, peel inwall immediately, cleaning, drying.[nature and flavor with return through] are sweet, flat.Return spleen, stomach, small intestinal, urinary bladder channel.[function with cure mainly] invigorating the stomach and promoting digestion, arresting seminal emission, treating stranguria fossil.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission, the puckery pain of stranguria caused by urinary stone, gallbladder-distention hypochondriac pain.
Ren sus domestica: be the kidney of mammal pig.Nature and flavor: salty, flat, nontoxic.Gui Jing: enter kidney.Effect: reason kidney qi, logical bladder, removing food stagnancy is stagnant, only quenches one's thirst.Cure mainly: the soreness of waist pain of suffering from a deficiency of the kidney caused, emission due to deficiency of the kidney, deaf, edema, dysuria.
Another aspect of the present invention there is provided the preparation method of the active component of pharmaceutical composition of the present invention, and the method is the ethanol extraction adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.
Scheme two: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
Scheme three: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The pharmaceutical composition for the treatment of renal calculus of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Urinary system calculus belongs to stranguria caused by urinary stone, sand Stranguria in traditional Chinese medical science gonorrhea, due to damp invasion of lower energizer, changes the scorching the moon that burns, decocts urine, become sandstone, alluvial water channel, and be stranguria caused by urinary stone.Amass in lower then bladder qi dysfunction, it is unfavorable to urinate, very then for go out can not, poverty-strickenly to feel bad, pain extending to the lower abdomen; Be stranded in, then affect the duty of kidney department urine, pent-up must not be let out down, and QI and blood is unsmooth, stagnation of QI and blood may bring about pain, is involved bladder, pudendum by kidney; It is then hematuria that sandstone hinders network.
The present invention for monarch drug, returns kidney, urinary bladder channel, dissipating blood stasis for subsidence of swelling, promoting the circulation of QI to relieve pain with Radix Cudraniae parasitism, Spora Lygodii; Herba Lysimachiae, Herba Plantaginis inducing diuresis for treating stranguria syndrome, removing toxic substances and promoting subsidence of swelling; Herba Portulacae, Folium Pyrrosiae have share cooling blood for hemostasis; Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, treating stranguria fossil; Ren sus domestica reason kidney qi, logical bladder, removing food stagnancy is stagnant.Full side's collocation is scientific and reasonable, and meet System of Chinese medicine, mutually work in coordination with, Chinese medicine of the present invention is had, and good clearing away heat and promoting diuresis is treating stranguria, strengthening the spleen to promote digestion effect.Often there is phenomenon of suffering from a deficiency of the kidney in renal calculus patient, gas, blood, Tianjin with the passing of time must be caused deficient, and insufficiency of vital energy and blood also can increase the weight of the process of suffering from a deficiency of the kidney, and increases the weight of lithiasis.Therefore when treating renal calculus, spleen invigorating profit temperature need be taken into account, synchronous therapeutic, to play the effect of clearing away heat and promoting diuresis calculus, strengthening spleen, tonifying kidney, making that disease is fully recovered rapidly, cure rate is high, relapse rate is low.
A kind of pharmaceutical composition for the treatment of renal calculus provided by the invention has the following advantages:
1, pharmaceutical composition provided by the invention effectively can treat renal calculus, the paroxysmal lumbago companion hematuria symptom caused calculus after treatment all improves significantly, anti-inflammatory effects is desirable, calculus total effective rate is 95.1%, routine urianlysis result total effective rate is 94.3%, and therapeutic effect compared with prior art has significant difference (P<0.05).
2, pharmaceutical composition provided by the invention is when being used for the treatment of renal calculus, can significantly eliminate or slow down shiver with cold, fever, urgent micturition, frequent micturition, dysurea, lumbago, unable, hematuria, pyuria, albuminuria etc. symptom within a short period of time, reduces patient suffering.
3, pharmaceutical composition preparation method of the present invention is simple, is applicable to basic medical unit or producer's production in enormous quantities.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
embodiment 1:
Get Spora Lygodii 30g, Radix Cudraniae parasitic 40g, Herba Lysimachiae 20g, Herba Plantaginis 20g, Herba Portulacae 20g, Folium Pyrrosiae 20g, Endothelium Corneum Gigeriae Galli 10g, Ren sus domestica 60g, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
embodiment 2:
Get Spora Lygodii 20g, Radix Cudraniae parasitic 30g, Herba Lysimachiae 10g, Herba Plantaginis 10g, Herba Portulacae 10g, Folium Pyrrosiae 10g, Endothelium Corneum Gigeriae Galli 8g, Ren sus domestica 50g, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, and when filtrate is concentrated into 60 DEG C, relative density is the extractum of 1.25, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
embodiment 3:
Get Spora Lygodii 40g, the parasitic 50g of Radix Cudraniae, Herba Lysimachiae 30g, Herba Plantaginis 30g, Herba Portulacae 30g, Folium Pyrrosiae 30g, Endothelium Corneum Gigeriae Galli 13g, Ren sus domestica 100g, extracting in water 3 times, three amount of water are equivalent to 12 times of medical material gross weight respectively, 8 times, 6 times, 3 hours respectively each extraction time, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, add ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.10, add 3 times that purified water ad pond om is medical material gross weight, fill, obtain mixture of the present invention.
embodiment 4:
Get Spora Lygodii 40g, Radix Cudraniae parasitic 30g, Herba Lysimachiae 20g, Herba Plantaginis 30g, Herba Portulacae 10g, Folium Pyrrosiae 20g, Endothelium Corneum Gigeriae Galli 10g, Ren sus domestica 80g, with alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
embodiment 5:
Get Spora Lygodii 35g, Radix Cudraniae parasitic 45g, Herba Lysimachiae 25g, Herba Plantaginis 30g, Herba Portulacae 15g, Folium Pyrrosiae 20g, Endothelium Corneum Gigeriae Galli 12g, Ren sus domestica 70g, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.
embodiment 6:
Get Spora Lygodii 30g, the parasitic 40g of Radix Cudraniae, Herba Lysimachiae 30g, Herba Plantaginis 10g, Herba Portulacae 30g, Folium Pyrrosiae 10g, Endothelium Corneum Gigeriae Galli 10g, Ren sus domestica 100g, extracting in water 2 times, each amount of water is equivalent to 12 times of medical material gross weight respectively, 10 times, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.
embodiment 7:
Take Spora Lygodii 30g, Radix Cudraniae parasitic 40g, Herba Lysimachiae 20g, Herba Plantaginis 20g, Herba Portulacae 20g, Folium Pyrrosiae 20g, Endothelium Corneum Gigeriae Galli 10g, Ren sus domestica 60g, clean, dry, pulverizing, obtains powder of the present invention.
clinical treatment is summed up
Clinical observation is carried out to the curative effect of calculus antiinflammatory of the present invention, by contrasting take medicine the calculus situation of Patients Before And After and treatment situation analysis calculus of the present invention, the anti-inflammatory effects of inflammation.
1 diagnosis basis
1.1 waists or epigastrium continue dull pain or the violent angor of paroxysmal, are radiated to homonymy hypogastric region or pudendum, can with being in a cold sweat, vomitting, feel sick during angor outbreak, and bilateral has the person of blocking to have urine retention simultaneously.
1.2 can have naked eyes or microscopic hematuria, hematuria aggravation during angor outbreak.
The visible calculus shade of 1.3 x-ray urinary system plain film great majority.
1.4 IVUs can determine that in plain abdominal radiograph, whether calcification shadow is relevant with urinary system further, can determine position, calculus place, with or without blocking, and can show x-ray radioparent calculus.
1.5 INGs, B ultrasonic, CT have certain help to diagnosis.
1.6 Urinary system inflammation
1.6.1 symptom
Disease sees shiver with cold, fever, urgent micturition, frequent micturition, dysurea, lumbago, unable, hematuria, pyuria etc., chronic phase inflammation or inflammation recurrent exerbation can there are edema, hypertension, albuminuria etc.
1.6.2 routine urianlysis
Specific gravity of urine increases or reduces, urine protein positive, glucose in urine positive, and microscopy finds that erythrocyte is greater than 3/HP, finds leukocyte and epithelial cell, cast etc.
2 case selections
At 25 ~ 60 years old age, be ready acceptance 2 weeks therapists.
3 medicines
Experimental group: embodiment 1 syrup
Matched group: PAISHI KELI, Nanjing Tongrentang Pharmaceutical Co., Ltd.
4 curative effect index
4.1 calculus situations
Cure: clinical symptoms and sign all disappear, calculus is discharged, and color ultrasound or abdomen plain film show that hydronephrosis disappears, and calculus shade disappears;
Take a turn for the better: clinical symptom disappearance, calculus moves down, reduce or part discharge, hydronephrosis disappears substantially;
Invalid: symptom is not improved, calculus is without mobile or hydronephrosis is unchanged.
4.2 urine routine test
Cure: clinical symptoms and sign all disappear; Urine routine test total negative;
Take a turn for the better: clinical symptom disappearance; Urine routine test has a little erythrocyte;
Invalid: symptom is not improved, urine routine test has erythrocyte, urine protein, epithelial cell;
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 100, man 43 example, female 57 example; Average about 43 years old; All patients are all diagnosed as renal calculus through color ultrasound or the inspection of abdomen plain film, and calculus diameter is between 0.25 ~ 1.22cm, and routine urianlysis etc. inspection is made a definite diagnosis exists urinary system infection.Case is divided into two groups at random.
Therapeutic Method:
Experimental group: the embodiment of the present invention 1 syrup, is equivalent to crude drug 30g each serving consumption, three times on the one.
Matched group: PAISHI KELI, each 1 bag, three times on the one.
Experimental group and matched group are being taken medicine simultaneously, and strengthen amount of drinking water every day, average daily drink amount is 3000 ~ 5000ml, takes exercises more, and based on jumping exercise or going upstairs motion, both hands are in dorsal part intersection knocking back lumbar part.
6 results
After in experimental example group case, most of patient takes the embodiment of the present invention 1 syrup, paroxysmal lumbago companion hematuria phenomenon reduces or disappears, and check through color ultrasound or abdomen plain film, calculus moves down, reduce or disappear, therapeutic outcome is in table 1, table 2.
Table 1 renal calculus therapeutic effect
| Group | Number of cases | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Experimental group | 70 | 54 | 13 | 3 | 95.1* |
| Matched group | 30 | 19 | 6 | 5 | 83.3 |
Note: compare with matched group, * P < 0.05.
Rear routine urianlysis result treated by table 2
| Group | Number of cases | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Experimental group | 70 | 33 | 33 | 4 | 94.3* |
| Matched group | 30 | 13 | 11 | 6 | 80.0 |
Note: compare with matched group, * P < 0.05.
Interpretation of result: experimental group and matched group all have good curative effect treating renal calculus, all improve significantly after treatment to the paroxysmal lumbago companion hematuria symptom that calculus causes; Show the routine urianlysis result of two groups of patients, the treatment of two groups all achieves good effect.But experimental group compares with matched group significant difference.Calculus of the present invention and anti-inflammatory effects more excellent compared with matched group, there is significant difference (P<0.05).It can thus be appreciated that lithagogue effect and the antiphlogistic effects of pharmaceutical composition of the present invention are significantly better than prior art.
model case:
Chen, man, 48 years old.Unexpected sensation lumbago unbearably, painful urination, urinate not freely with gross hematuria, routine urianlysis: erythrocyte +++, albumen+, epithelial cell ++.B is super detects prompting: left renal calculus 2 pieces, largest diameter person 0.7cm.Give the embodiment of the present invention 4 tablet, 3 times on the 1st, each 6 times.After taking medicine 1 week, all diseases disappear, and urine is normal.Further consultation after two weeks, patient is without lumbago, and urine is freely sharp, spiritual amelioration.Check routine urinalysis: erythrocyte+, all the other are negative.The left kidney of the super report of B is shown in 1 piece, calculus.Continue to take two weeks, every day, amount of drinking water was about 4000ml, further consultation result: patient's private prosecution is without uncomfortable, and the limpid smooth profit of urine, thready and rolling pulse, light red tongue, white and thin fur, again checks routine urinalysis, super the detecting of B points out two kidney, ureter, bladder to be showed no calculus.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (7)
1. treat the pharmaceutical composition of renal calculus, it is characterized in that it is prepared from by the raw material of following weight portion: Spora Lygodii 20-40 part, the parasitic 30-50 part of Radix Cudraniae, Herba Lysimachiae 10-30 part, Herba Plantaginis 10-30 part, Herba Portulacae 10-30 part, Folium Pyrrosiae 10-30 part, Endothelium Corneum Gigeriae Galli 8-13 part, Ren sus domestica 50-100 part.
2. pharmaceutical composition according to claim 1, is characterized in that it is prepared from by the raw material of following weight portion: parasitic 40 parts of Spora Lygodii 30 parts, Radix Cudraniae, Herba Lysimachiae 20 parts, Herba Plantaginis 20 parts, Herba Portulacae 20 parts, Folium Pyrrosiae 20 parts, Endothelium Corneum Gigeriae Galli 10 parts, Ren sus domestica 60 parts.
3. pharmaceutical composition as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains described active component.
5. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
6. pharmaceutical composition as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains described active component.
7. treat the pharmaceutical composition of renal calculus, prepared into acceptable carrier in pharmaceuticals industry by the pharmaceutical composition for the treatment of renal calculus described in claim 1 or 2.
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