CN104888097A - Traditional Chinese medicine composition for preventing urinary calculus, and application thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for preventing urinary calculus, which comprises desmodium, waternut herb, semen abutili, ainsliaea spicata vant, nervilia fordii schltr, garden burnet, coix lachryma-jobi, calabash, securidaca inappendiculata hassk, chicken's gizzard membrane, lygodium japonicum, otolhum pseudoscinaenae, pyrrosia lingua, dianthus superbus, rhizome curcuma, gentrin knotweed, cassia twig, tree peony bark, fleece-flower root, cyathula root, plantain seed and licorice. Practice has proven that, the above traditional Chinese medicine composition is better in curative effect and small in toxic and side effect, thus being suitable for long-term administration. The traditional Chinese medicine composition is wide in wide in clinical application value. The traditional Chinese medicine composition serves as a safe and effective medicament used for treating urinary calculus.

Description

A kind of Chinese medicine composition and application thereof preventing and treating urinary system calculus

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition and the application thereof that prevent and treat urinary system calculus.

Background technology

The calculus occurred at the kidney of human body urinary system, ureter, bladder, urethra is referred to as urinary system calculus, also known as urinary calculus.Wherein urinary system calculus, ureteral calculus are called as upper urinary stone; Vesical calculus, calculus of urethra is called calculus of lower urinary tract.Urinary calculus is global commonly encountered diseases, also higher at the sickness rate of China.Urinary stone look the same stone, is actually the one performance of human body abnormal mineralization, can be seen as a kind of biological Ore.Calcium oxalate stone, phosphatic calculus, urate calculus, cystine stone, xanthic calculus can be divided into according to calculus composition.The genetic facies of urinary stone, when complicated, thought that urinary stone is not the disease of single reason at present more at large, but is facilitated by many factors.The generation of urinary system calculus by urine acid-base value, whether urinary tract exists blocks, whether urinary tract has foreign body and health some other diseases impact.

Sickness rate is on the rise in recent years, and according to incompletely statistics, at the sickness rate of China's urinary system calculus about 15%, the sickness rate of urinary system calculus has obvious regional difference, and the sickness rate of southern china is far above the north.The generation development of urinary system calculus and nutriture have substantial connection, based on vegetable protein in poor and backward national food, lack phosphate in urine, easily vesical calculus occur, and children's is particularly common, and developed country's common adult's calcic renal calculus.The blocking of urinary system, foreign body and infection can promote the formation of urinary system calculus, otherwise urinary system calculus can be again the reason of blocking, infecting.Metabolic disease such as the Developmental and Metabolic Disorder such as hyperparathyroidism, gout, oxalic acid and cystine also can be the reasons that urinary system calculus is formed.Concerning urinary system calculus, after treatment, the lithogenous factor of shape is not resolved, and if do not noted preventive measure, calculus also likely recurs.According to statistics, 1 year relapse rate of calcium oxalate renal calculus is 10%, 5 years relapse rates be 35%, 10 years relapse rates is 50%.Therefore, the prevention work of urinary calculus should be paid close attention to.

The patient of urinary system calculus disease is very common clinically, and symptomatic reaction can be pain, hematuria, frequent micturition, urgent micturition, generates heat, shivers.A lot of patient is through operation or non-operative treatment, and calculus is temporarily removed.If minimal invasive treatment paid no heed to, the urinary system calculus disease cured will be recurred, and generates new calculus, and patient is very painful.

The cause of disease of urinary system calculus is very complicated, it with natural environment, social condition, general metabolic disturbance and urinary system itself illness relevant.At present substantially clear to the understanding of the local factor of urinary system itself, but comprehensive not enough to the understanding of the formation relation of general metabolic disturbance and urinary system calculus.

There is multiple method at present, comprise extracorporeal shock-wave lithotripsy (ESWL), PCN, various endoscope gets stone or lithotrity can be selected for us, and have accumulated a large amount of experiences, a few patients is only had to need traditional open surgery treatment, but the problem that after renal calculus operative treatment, relapse rate is high annoyings Urology Surgery doctor all the time, from traditional Chinese medical science angle, it is controlled and can only take stopgap measures, be difficult to reach the object of effecting a permanent cure, and renal calculus operative treatment has certain indication, also certain complication is had, as: induced renal damage, postoperative fever, wound infection, septicemia, postoperative hemorrhage etc.Doctor trained in Western medicine effect in treatment is also undesirable.Rubble, contraindication is many, operation, and wound is large, and relapse rate is high.The Chinese medicine and the Western medicine that are now commercially used for the treatment of calculus are varied, when taking, the property of medicine is slower, the course for the treatment of is longer, cure rate is not high, and medicine on market mostly can only mitigate the disease, can not cure, some medicine has larger side effect, needs of patients prolonged administration of drugs, therapeutic effect is undesirable.

Summary of the invention

The object of the invention is to solve the weak point that above-mentioned prior art exists, the Chinese medicine composition of the treatment urinary system calculus providing a kind of determined curative effect, side effect little, with low cost.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Prevent and treat a Chinese medicine composition for urinary system calculus, the crude drug of described Chinese medicine composition is made up of Herba Lysimachiae, Herba Eleocharitis, Semen Abutili, Herba Ainsliaeae ovovatae, Folium Nerviliae fordii, Radix Sanguisorbae, Radix Coicis, Pericarpium Lagenariae sicerariae, Radix securidacae, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Asteriscus Pseudosciaenae, Folium Pyrrosiae, Herba Dianthi, Rhizoma Curcumae, Rhizoma Polygoni Cuspidati, Ramulus Cinnamomi, Cortex Moutan, Radix Polygoni Multiflori, Radix Cyathulae, Semen Plantaginis, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 12-20 part, Semen Abutili 10-16 part, Radix Polygoni Multiflori 3-8 part, Herba Ainsliaeae ovovatae 5-12 part, Folium Nerviliae fordii 12-17 part, Herba Eleocharitis 7-12 part, Herba Dianthi 4-9 part, Radix Coicis 15-20 part, Pericarpium Lagenariae sicerariae 10-15 part, Endothelium Corneum Gigeriae Galli 8-12 part, Spora Lygodii 2-5 part, Radix Sanguisorbae 3-7 part, Asteriscus Pseudosciaenae 11-14 part, Folium Pyrrosiae 9-15 part, Radix Cyathulae 3-6 part, Rhizoma Curcumae 8-13 part, Ramulus Cinnamomi 3-5 part, Cortex Moutan 1-3 part, Semen Plantaginis 5-10 part, Radix securidacae 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Radix Glycyrrhizae 3-10 part.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 12 parts, Semen Abutili 16 parts, Radix Polygoni Multiflori 3 parts, Herba Ainsliaeae ovovatae 12 parts, Folium Nerviliae fordii 12 parts, Herba Eleocharitis 10 parts, Herba Dianthi 9 parts, Radix Coicis 15 parts, Pericarpium Lagenariae sicerariae 15 parts, Endothelium Corneum Gigeriae Galli 8 parts, Spora Lygodii 5 parts, Radix Sanguisorbae 3 parts, Asteriscus Pseudosciaenae 14 parts, Folium Pyrrosiae 9 parts, Radix Cyathulae 6 parts, Rhizoma Curcumae 8 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 1 part, Semen Plantaginis 10 parts, Radix securidacae 5 parts, Rhizoma Polygoni Cuspidati 16 parts, 10 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 20 parts, Semen Abutili 10 parts, Radix Polygoni Multiflori 8 parts, Herba Ainsliaeae ovovatae 5 parts, Folium Nerviliae fordii 17 parts, Herba Eleocharitis 12 parts, Herba Dianthi 4 parts, Radix Coicis 20 parts, Pericarpium Lagenariae sicerariae 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Spora Lygodii 2 parts, Radix Sanguisorbae 7 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 15 parts, Radix Cyathulae 3 parts, Rhizoma Curcumae 13 parts, Ramulus Cinnamomi 3 parts, Cortex Moutan 3 parts, Semen Plantaginis 5 parts, Radix securidacae 10 parts, Rhizoma Polygoni Cuspidati 13 parts, 3 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 13 parts, Semen Abutili 11 parts, Radix Polygoni Multiflori 4 parts, Herba Ainsliaeae ovovatae 6 parts, Folium Nerviliae fordii 13 parts, Herba Eleocharitis 7 parts, Herba Dianthi 5 parts, Radix Coicis 18 parts, Pericarpium Lagenariae sicerariae 11 parts, Endothelium Corneum Gigeriae Galli 9 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 6 parts, Asteriscus Pseudosciaenae 12 parts, Folium Pyrrosiae 13 parts, Radix Cyathulae 4 parts, Rhizoma Curcumae 9 parts, Ramulus Cinnamomi 4 parts, Cortex Moutan 2 parts, Semen Plantaginis 6 parts, Radix securidacae 6 parts, Rhizoma Polygoni Cuspidati 14 parts, 5 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 17 parts, Semen Abutili 15 parts, Radix Polygoni Multiflori 7 parts, Herba Ainsliaeae ovovatae 11 parts, Folium Nerviliae fordii 16 parts, Herba Eleocharitis 8 parts, Herba Dianthi 8 parts, Radix Coicis 16 parts, Pericarpium Lagenariae sicerariae 14 parts, Endothelium Corneum Gigeriae Galli 11 parts, Spora Lygodii 3 parts, Radix Sanguisorbae 5 parts, Asteriscus Pseudosciaenae 13 parts, Folium Pyrrosiae 14 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 12 parts, Ramulus Cinnamomi 3 parts, Cortex Moutan 1 part, Semen Plantaginis 10 parts, Radix securidacae 9 parts, Rhizoma Polygoni Cuspidati 13 parts, 7 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 15 parts, Semen Abutili 12 parts, Radix Polygoni Multiflori 5 parts, Herba Ainsliaeae ovovatae 9 parts, Folium Nerviliae fordii 15 parts, Herba Eleocharitis 9 parts, Herba Dianthi 7 parts, Radix Coicis 19 parts, Pericarpium Lagenariae sicerariae 13 parts, Endothelium Corneum Gigeriae Galli 10 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 4 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 11 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 10 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 3 parts, Semen Plantaginis 8 parts, Radix securidacae 8 parts, Rhizoma Polygoni Cuspidati 14 parts, 9 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 19 parts, Semen Abutili 14 parts, Radix Polygoni Multiflori 6 parts, Herba Ainsliaeae ovovatae 7 parts, Folium Nerviliae fordii 14 parts, Herba Eleocharitis 9 parts, Herba Dianthi 6 parts, Radix Coicis 17 parts, Pericarpium Lagenariae sicerariae 13 parts, Endothelium Corneum Gigeriae Galli 10 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 4 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 11 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 10 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 3 parts, Semen Plantaginis 8 parts, Radix securidacae 8 parts, Rhizoma Polygoni Cuspidati 14 parts, 4 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared by the following method:

(1) get arbitrary proportioning and take each raw material composition, each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.2; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to a kind of application of Chinese medicine composition in control urinary system calculus medicine preventing and treating urinary system calculus.

The traditional Chinese medical science is thought, urinary system calculus belongs to traditional Chinese medical science sand, stranguria caused by urinary stone category.The pathogenesis that gets to the bottom of sb.'s illness is the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, retardance mechanism of qi, and cause QI-blood circulation smooth, body fluid running is unfavorable, and with the passing of time body fluid decocted by pathogenic heat, gathers and forms stone, calculus and damp and hot stop, hinders QI-blood circulation to become blood stasis; Calculus damage blood network, blood is excessive, or internal resistance forms blood stasis, and thus damp and hot blood stasis is the Etiological of calculus; Suffering from a deficiency of the kidney and to cause functioning of bladder unfavorable, is lithogenous inherent basic factor; Body resistance against diseases is low, then can because of disturbance in functioning of QI the stasis of blood stagnant, or because of damp and hot accumulation, QI and blood accumulation of heat, causes calculus, kidney asthenia as the principal aspect, and the domination of pathogen is mark.Therefore clinical establishment of the therapeutic methods and Applying Medicine, turn round and look at when constantly and protect kidney qi, accomplish disappear middle residence benefit, treating both the principal and secondary aspects of a disease, the kidney invigorating gas can improve renal function, perfects separating clear and excreting turbid function, adjusts smooth QI and blood, tonneau water channel, thus calculus is discharged from focus.Therefore treat the feasible at present of urinary system calculus and one of effective method from the angle of the traditional Chinese medical science.

The Chinese medicine composition of control urinary system calculus provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.

Herba Eleocharitis, bitter in the mouth, cool in nature, return spleen, kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Diuresis; Sending down the abnormal ascending QI.Main pyretic stranguria; Dysuria; Edema; Furuncle; Singultus.Soviet Union doctor " Chinese herbal medicine hands phenol ": heat clearing away, diuresis.Control dysuria, singultus.

Semen Abutili sweet in the mouth, cold in nature, the effect such as return stomach, liver, lung, large intestine, small intestinal, urinary bladder channel, there is fossil, diuresis, treating stranguria, calculus, QI invigorating, nourish blood.

Herba Ainsliaeae ovovatae: different name Folium Pruni Ainsliaea fragrans Champ. is the herb of feverfew Acanthopanax obovatus Hoo Ainsliaea fragrans Champ..Property mildly bitter flavor, cool.Antiinflammatory diuresis, heat-clearing and toxic substances removing.Treating acute and chronic nephritis, pyelitis, urinary tract infection.

Folium Nerviliae fordii, bitter, sweet, flat.Function cures mainly: clearing away lung-heat to relieve cough, spleen invigorating removing food stagnancy, sedation-analgesia, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For pulmonary tuberculosis cough spitting of blood, bronchitis, infantile malnutrition, infantile pneumonia, psychosis, treating swelling and pain by traumatic injury, stomatitis, acute laryngitis, sore.

Radix Sanguisorbae: the root and rhizome of rosaceous plant Radix Sanguisorbae.Whole nation most area all has distribution.Nature and flavor picric acid, cold.Return Liver Channel, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing.Cure mainly haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, pain is swollen, eczema etc.

Radix Coicis, bitter sweet, cold.Enter spleen, urinary bladder channel.Function cures mainly: heat clearing away, dampness removing, spleen invigorating, parasite killing.To harness the Yellow River subcutaneous ulcer, edema, gonorrhea, hernia, amenorrhea, leukorrhagia, abdominal pain due to worm stagnation.

Pericarpium Lagenariae sicerariae: the fruit of cucurbitaceous plant lagenaria sicerariae.Whole nation most area all has cultivation.Nature and flavor are sweet, light, flat.Return lung meridian, spleen channel, kidney channel.Diuretic, treating stranguria.Cure mainly edema, abdominal distention, jaundice, gonorrhea.

Radix securidacae, arduous, be slightly cold.Function cures mainly: promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis.Control acute gastroenteritis, traumatic injury.

Endothelium Corneum Gigeriae Galli: property is sweet puts down, be slightly cold, nontoxic, returns spleen, stomach, kidney, urinary bladder channel.Cure mainly: can promoting digestion and invigorating the stomach, arresting seminal emission, fossil.Removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.

Spora Lygodii: sweet in the mouth, cold in nature.Return bladder, small intestine meridian.Cure mainly: stranguria.Its property of this product declines, kind clear small intestinal, damp-heat in the urinary bladder, and outstanding kind only urethra pain, for controlling the key medicine of the puckery pain of all pouring.Herb: holding concurrently can heat-clearing and toxic substances removing.Wipe out and treat insect pests and plant diseases stranguria, for carbuncle sore tumefacting virus, mumps and jaundice.

Asteriscus Pseudosciaenae: salty in the mouth, property is put down.Function cures mainly: fossil, treating stranguria, antiinflammatory.Control stranguria caused by urinary stone, dysuria, otitis media, rhinitis, sinusitis with purulent discharge.

Folium Pyrrosiae: acrid in the mouth, property is put down.Function: relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.

Herba Dianthi: bitter, cold.Enter the heart, kidney, small intestine meridian.Function cures mainly: inducing diuresis for treating stranguria syndrome, and removing blood stasis stimulates the menstrual flow.For pyretic stranguria, stranguria with blood, stranguria caused by urinary stone, urinary obstruction, the puckery pain of pouring drop, increase warp.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Function: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Expelling wind and removing dampness, reducing swelling and alleviating pain.For rheumatalgia, wind syndrome of head pain, chest and hypochondrium, diarrhoea pain; Traumatic injury is controlled in external, swelling and pain due to blood stasis.

Rhizoma Polygoni Cuspidati mildly bitter flavor, cold nature, returns liver, gallbladder, kidney channel, there is heat clearing away, removing toxic substances, function of gallbladder promoting, jaundice eliminating, dispel the wind, dampness removing, dissipating blood stasis analgesic therapy, cough-relieving, the effect such as to reduce phlegm.Join the chemical compositions such as glycoside containing dissociated anthraquinone and anthracene in the water decoction of Rhizoma Polygoni Cuspidati, be usually used in the illness such as cholecystitis, cholelithiasis, acute infectious hepatitis, and person is rather in step with to have jaundice to belong to Accumulation of Dampness Heat and Blood Stasis.

Ramulus Cinnamomi acrid-sweet flavor, warm in nature, it is the interior temperature medicine that interior cold is commonly used, there is effect of complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, has the effect of significantly analgesia and anti-cancer and cancer-preventing.

Cortex Moutan, bitter, pungent, be slightly cold, GUIXIN, liver, kidney channel, have the effects such as clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, reducing the asthenic fever.

Radix Polygoni Multiflori bitter in the mouth, sweet; Puckery, slightly warm in nature, returns liver, kidney channel.Mainly contain nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify.Cure mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.

Radix Cyathulae: sweet, the micro-hardship of nature and flavor, property is put down; Return liver, kidney channel.Effect: there is promoting blood circulation to restore menstrual flow, expelling wind and removing dampness, easing joint movement, effect of inducing diuresis for treating stranguria syndrome; Cure mainly blood stasis amenorrhea, dysmenorrhea, difficult labour, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria, stranguria with blood, injury from falling down.

Semen Plantaginis: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

In Chinese medicine composition object space of the present invention:

Herba Lysimachiae returns liver, gallbladder, kidney, urinary bladder channel, relieving stranguria by diuresis, heat-clearing and toxic substances removing, Herba Eleocharitis, Herba Ainsliaeae ovovatae antiinflammatory diuresis, heat-clearing and toxic substances removing, and Herba Lysimachiae, Herba Eleocharitis, Herba Ainsliaeae ovovatae are monarch drug altogether;

Radix securidacae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis, Folium Nerviliae fordii heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, Radix Coicis heat clearing away, dampness removing, Pericarpium Lagenariae sicerariae diuretic, treating stranguria, Asteriscus Pseudosciaenae fossil, treating stranguria, antiinflammatory, Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, Radix securidacae, Folium Nerviliae fordii, Radix Coicis, Pericarpium Lagenariae sicerariae, Asteriscus Pseudosciaenae, Semen Plantaginis are ministerial drug altogether, principal drug assistance fossil, relieving stranguria by diuresis, eliminating dampness by diuresis;

Endothelium Corneum Gigeriae Galli, Semen Abutili, Radix Cyathulae fossil, diuresis, treating stranguria, Spora Lygodii, Rhizoma Curcumae reducing swelling and alleviating pain, Radix Sanguisorbae cooling blood for hemostasis, heat-clearing and toxic substances removing, Folium Pyrrosiae, Herba Dianthi relieving stranguria by diuresis, heat clearing away is stimulated the menstrual flow, Rhizoma Polygoni Cuspidati heat clearing away, detoxify, dispel the wind, dampness removing, Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, Radix Polygoni Multiflori nourishing the blood and yin, dispel the wind, detoxify, Ramulus Cinnamomi taste complement sun, ventilation quality, promoting blood circulation are adjuvant drug altogether;

Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for making medicine.

All medicines share, and can reach effect of clearing away heat and promoting diuresis, blood circulation promoting and blood stasis dispelling, Sal Nitri diuresis, clearing away heat-damp and promoting diuresis, alleviation pain relieving.

Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, its compatibility meets Chinese medicine " monarch " principle, verifies through pharmacodynamic experiment, there is oxalic acid, calcium content, significantly analgesia and diuresis in significant reduction calculus degree, nephridial tissue.Facts have proved, Chinese medicine composition of the present invention obtains good curative effect, and toxic and side effects is little, is suitable for long-term taking, has clinical value widely.It is a kind of medicine for the treatment of urinary system calculus disease safely and effectively.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 12 grams, Semen Abutili 16 grams, Radix Polygoni Multiflori 3 grams, Herba Ainsliaeae ovovatae 12 grams, Folium Nerviliae fordii 12 grams, Herba Eleocharitis 10 grams, Herba Dianthi 9 grams, Radix Coicis 15 grams, Pericarpium Lagenariae sicerariae 15 grams, Endothelium Corneum Gigeriae Galli 8 grams, Spora Lygodii 5 grams, Radix Sanguisorbae 3 grams, Asteriscus Pseudosciaenae 14 grams, Folium Pyrrosiae 9 grams, Radix Cyathulae 6 grams, Rhizoma Curcumae 8 grams, Ramulus Cinnamomi 5 grams, Cortex Moutan 1 gram, Semen Plantaginis 10 grams, Radix securidacae 5 grams, Rhizoma Polygoni Cuspidati 16 grams, 10 grams, Radix Glycyrrhizae.

Embodiment 2:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 20 grams, Semen Abutili 10 grams, Radix Polygoni Multiflori 8 grams, Herba Ainsliaeae ovovatae 5 grams, Folium Nerviliae fordii 17 grams, Herba Eleocharitis 12 grams, Herba Dianthi 4 grams, Radix Coicis 20 grams, Pericarpium Lagenariae sicerariae 10 grams, Endothelium Corneum Gigeriae Galli 12 grams, Spora Lygodii 2 grams, Radix Sanguisorbae 7 grams, Asteriscus Pseudosciaenae 11 grams, Folium Pyrrosiae 15 grams, Radix Cyathulae 3 grams, Rhizoma Curcumae 13 grams, Ramulus Cinnamomi 3 grams, Cortex Moutan 3 grams, Semen Plantaginis 5 grams, Radix securidacae 10 grams, Rhizoma Polygoni Cuspidati 13 grams, 3 grams, Radix Glycyrrhizae.

Embodiment 3:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 13 grams, Semen Abutili 11 grams, Radix Polygoni Multiflori 4 grams, Herba Ainsliaeae ovovatae 6 grams, Folium Nerviliae fordii 13 grams, Herba Eleocharitis 7 grams, Herba Dianthi 5 grams, Radix Coicis 18 grams, Pericarpium Lagenariae sicerariae 11 grams, Endothelium Corneum Gigeriae Galli 9 grams, Spora Lygodii 4 grams, Radix Sanguisorbae 6 grams, Asteriscus Pseudosciaenae 12 grams, Folium Pyrrosiae 13 grams, Radix Cyathulae 4 grams, Rhizoma Curcumae 9 grams, Ramulus Cinnamomi 4 grams, Cortex Moutan 2 grams, Semen Plantaginis 6 grams, Radix securidacae 6 grams, Rhizoma Polygoni Cuspidati 14 grams, 5 grams, Radix Glycyrrhizae.

Embodiment 4:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 17 grams, Semen Abutili 15 grams, Radix Polygoni Multiflori 7 grams, Herba Ainsliaeae ovovatae 11 grams, Folium Nerviliae fordii 16 grams, Herba Eleocharitis 8 grams, Herba Dianthi 8 grams, Radix Coicis 16 grams, Pericarpium Lagenariae sicerariae 14 grams, Endothelium Corneum Gigeriae Galli 11 grams, Spora Lygodii 3 grams, Radix Sanguisorbae 5 grams, Asteriscus Pseudosciaenae 13 grams, Folium Pyrrosiae 14 grams, Radix Cyathulae 5 grams, Rhizoma Curcumae 12 grams, Ramulus Cinnamomi 3 grams, Cortex Moutan 1 gram, Semen Plantaginis 10 grams, Radix securidacae 9 grams, Rhizoma Polygoni Cuspidati 13 grams, 7 grams, Radix Glycyrrhizae.

Embodiment 5:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 15 grams, Semen Abutili 12 grams, Radix Polygoni Multiflori 5 grams, Herba Ainsliaeae ovovatae 9 grams, Folium Nerviliae fordii 15 grams, Herba Eleocharitis 9 grams, Herba Dianthi 7 grams, Radix Coicis 19 grams, Pericarpium Lagenariae sicerariae 13 grams, Endothelium Corneum Gigeriae Galli 10 grams, Spora Lygodii 4 grams, Radix Sanguisorbae 4 grams, Asteriscus Pseudosciaenae 11 grams, Folium Pyrrosiae 11 grams, Radix Cyathulae 5 grams, Rhizoma Curcumae 10 grams, Ramulus Cinnamomi 5 grams, Cortex Moutan 3 grams, Semen Plantaginis 8 grams, Radix securidacae 8 grams, Rhizoma Polygoni Cuspidati 14 grams, 9 grams, Radix Glycyrrhizae.

Embodiment 6:

A kind of Chinese medicine composition preventing and treating urinary system calculus of the present invention, gets following traditional Chinese medicine raw medicine: Herba Lysimachiae 19 grams, Semen Abutili 14 grams, Radix Polygoni Multiflori 6 grams, Herba Ainsliaeae ovovatae 7 grams, Folium Nerviliae fordii 14 grams, Herba Eleocharitis 9 grams, Herba Dianthi 6 grams, Radix Coicis 17 grams, Pericarpium Lagenariae sicerariae 13 grams, Endothelium Corneum Gigeriae Galli 10 grams, Spora Lygodii 4 grams, Radix Sanguisorbae 4 grams, Asteriscus Pseudosciaenae 11 grams, Folium Pyrrosiae 11 grams, Radix Cyathulae 5 grams, Rhizoma Curcumae 10 grams, Ramulus Cinnamomi 5 grams, Cortex Moutan 3 grams, Semen Plantaginis 8 grams, Radix securidacae 8 grams, Rhizoma Polygoni Cuspidati 14 grams, 4 grams, Radix Glycyrrhizae.

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decoct 1-2 hour: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.2; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test:

Get mice 60, body weight 20-22 gram, be divided into 2 groups at random by body weight, treatment group and matched group: treatment group takes powder prepared by the embodiment of the present invention 2, and 0.42ml/10g body weight gastric infusion is pressed in fasting after 12 hours, dose 0.45g/ml, matched group takes distilled water, three times on the one, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical trial:

In order to verify the effect of Chinese medicine composition of the present invention, in November ,-2014 in January, 2013, outpatient service place random selecting Patients with Urinary Stone 200 example, wherein 153 examples have the symptom such as waist abdomen pain and paruria in various degree, waist stomachache show as paroxysmal aggravation and to lower abdomen and perineal position radiating pain, or with Nausea and vomiting, be in a cold sweat; 47 routine symptoms are not obvious, in health check-up, find lithangiuria.All cases is all taken the photograph sheet or intravenous urography or CT scan through B ultrasonic or abdominal X-ray and is diagnosed as urinary system calculus.Random digits table is adopted to be divided into treatment group and matched group at random, wherein treatment group 100 example, 19 ~ 63 years old age, average 33.6 years old, average 2.6 years of the course of disease.Matched group 100 example, 21 ~ 66 years old age, average 34.5 years old; Average 2.2 years of the course of disease.2 groups of sexes, age, courses of disease etc. compare, and difference there are no significant meaning (P>0.05), has comparability.

Diagnostic criteria:

(1) clinical symptoms majority has side or bilateral waist and belly rest pain, paroxysmal colic, with or do not accompany the symptoms such as Nausea and vomiting, hematuria, frequent micturition, urgent micturition;

(2) urine microscopy has erythrocyte or the occult blood positive;

(3) ultrasonic and x-ray abdomen plain film or renal phlebography show calculus image or light, moderate hydronephrosis, without obvious renal function injury, without urinary tract deformity.

Therapeutic Method:

Treatment group takes the granule that the embodiment of the present invention 2 makes, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, treat 3 ~ 4 courses for the treatment of altogether.

Matched group takes uralyt (German Warsaw pharmaceutical factory produces, and China imports and exports No. X960447, drug registration card, No. 1014886th, China trademark registration certificate), each 2, every day 2 times.Two groups equal 7 days be 1 course for the treatment of, serve on 3 courses for the treatment of.

Efficacy assessment standard:

Cure: clinical symptoms, sign disappear, and calculus is discharged;

Effective: clinical symptoms, sign disappear, but calculus is not discharged or part calculus excretes;

Effective: clinical symptoms, sign make moderate progress, and calculus reduces;

Invalid: clinical symptoms, sign have no change, calculus is also unchanged.

Clinical observation result is in table 1:

The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating urinary system calculus of the present invention

Group	Case	Cure	Effective	Effectively	Invalid	Total effective rate
							Matched group	100	25	29	11	35	65％
Treatment group	100	76	13	7	4	96％

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for Patients with Urinary Stone; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.

Model case:

Case 1

Zhao, man, 61 years old is Qingdao City Laoshan District people, goes to a doctor on March 16th, 2013.Suffer from the calculus several years, renal colic constantly, through ultrasound diagnosis, for multiple pair of renal calculus, extracorporeal shock wave lithotripsy was done before February, exceed March now, sandstone sample thing is still frequently had to discharge urethra dull pain with urine, blood is with in urine, low grade fever is had during night, mouth is not thirsty, red tongue tongue is thick in vain, wiry and frequent pulse, through ultrasound diagnosis: both sides ureter has multiple 3mm × 4mm high light group, without hydronephrosis, routine urianlysis: leukocyte (+) erythrocyte (+++), pus cell (+) calcium urate crystallization (+++), blood routine examination: leukocyte 1.3 × 1012/L, examine as stone residual after rubble is detained, damage urethral wall, infect and formed, the capsule giving the embodiment of the present invention 5 is treated, twice daily, each two, 10 days courses for the treatment of, after the course for the treatment of, and advise period in a medicine reinforcement activity, great quantity of water drinking is discharged with short calculus, further consultation after 7 days, discharge 6 ~ 7, sand sample stone, now urinate color and turn white, night is not hot, urine is not bitterly, transference cure, fully recover after continuing to take two courses for the treatment of, follow up a case by regular visits to more than 2 years calculus not recur.

Case 2

Money, man, 55 years old, Qingdao Jimo people, went to a doctor on May 1st, 2013.Multiple pair of renal calculus was suffered from readme before 2 years, after extracorporeal shock-wave lithotripsy, sediment outflow sample stone first quarter moon mores than more than 30 grains, continues to take SHILINTONG PIAN every day simultaneously.Existing disease hematuria every day 1 ~ 2 time, has weekly calculus sense 1 time.Through ultrasound diagnosis, two kidney finds without calculus, and without hydrops, bilateral ureteral has multiple 1mm × 5mm hot spot.Routine urinalysis: erythrocyte (+++), leukocyte (+) urine calcium crystallization (++), all the other are normal, and patient's pallor, the dark tongue of tongue is thick in vain, thready and hesitant pulse.Urinate without pain, during urine, have kermesinus blood point.Arteries and veins disease is referred and synthesized, be diagnosed as stranguria caused by urinary stone and hold the stasis of blood under the arm, the granule giving the embodiment of the present invention 6 is treated, twice daily, each two bags, 10 days courses for the treatment of, after 3 courses for the treatment of, symptom disappears substantially, continue to take a course for the treatment of, within nearly 2 years, do not find hematuria, B ultrasonic is checked: two kidney, bilateral ureteral, bladder does not find calculus.

Case 3

Grandson, female, 47 years old, people from Shinan District, Qingdao City, went to a doctor on November 23rd, 2013.Right renal calculus is suffered from before first quarter moon, through taking traditional Chinese medicine, discharge 1 7mm × 5mm, 6.3mm × 5.2mm calculus, nearly four or five days, patient's anorexia and loose stool, night abdominal distention frequent micturition, extremity are not warm, few abdomen is cold, through ultrasound diagnosis, right kidney has 5mm × 4mm high light group, check routine urinalysis: calcium urate crystallization (++), patient's complexion white light is white, tired mind, pulse condition is heavy thin, the medicine decoction giving the embodiment of the present invention 1 is treated, twice daily, 10 days courses for the treatment of, after 2 courses for the treatment of, night, abdomen was not swollen, extremity and few abdomen turn temperature, sleep takes a turn for the better, after continuing to take three courses for the treatment of, calculus is discharged, transference cure, without recurrence.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. prevent and treat a Chinese medicine composition for urinary system calculus, it is characterized in that: the crude drug of described Chinese medicine composition is made up of Herba Lysimachiae, Herba Eleocharitis, Semen Abutili, Herba Ainsliaeae ovovatae, Folium Nerviliae fordii, Radix Sanguisorbae, Radix Coicis, Pericarpium Lagenariae sicerariae, Radix securidacae, Endothelium Corneum Gigeriae Galli, Spora Lygodii, Asteriscus Pseudosciaenae, Folium Pyrrosiae, Herba Dianthi, Rhizoma Curcumae, Rhizoma Polygoni Cuspidati, Ramulus Cinnamomi, Cortex Moutan, Radix Polygoni Multiflori, Radix Cyathulae, Semen Plantaginis, Radix Glycyrrhizae.

2. the Chinese medicine composition of control urinary system calculus according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 12-20 part, Semen Abutili 10-16 part, Radix Polygoni Multiflori 3-8 part, Herba Ainsliaeae ovovatae 5-12 part, Folium Nerviliae fordii 12-17 part, Herba Eleocharitis 7-12 part, Herba Dianthi 4-9 part, Radix Coicis 15-20 part, Pericarpium Lagenariae sicerariae 10-15 part, Endothelium Corneum Gigeriae Galli 8-12 part, Spora Lygodii 2-5 part, Radix Sanguisorbae 3-7 part, Asteriscus Pseudosciaenae 11-14 part, Folium Pyrrosiae 9-15 part, Radix Cyathulae 3-6 part, Rhizoma Curcumae 8-13 part, Ramulus Cinnamomi 3-5 part, Cortex Moutan 1-3 part, Semen Plantaginis 5-10 part, Radix securidacae 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Radix Glycyrrhizae 3-10 part.

3. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 12 parts, Semen Abutili 16 parts, Radix Polygoni Multiflori 3 parts, Herba Ainsliaeae ovovatae 12 parts, Folium Nerviliae fordii 12 parts, Herba Eleocharitis 10 parts, Herba Dianthi 9 parts, Radix Coicis 15 parts, Pericarpium Lagenariae sicerariae 15 parts, Endothelium Corneum Gigeriae Galli 8 parts, Spora Lygodii 5 parts, Radix Sanguisorbae 3 parts, Asteriscus Pseudosciaenae 14 parts, Folium Pyrrosiae 9 parts, Radix Cyathulae 6 parts, Rhizoma Curcumae 8 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 1 part, Semen Plantaginis 10 parts, Radix securidacae 5 parts, Rhizoma Polygoni Cuspidati 16 parts, 10 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 20 parts, Semen Abutili 10 parts, Radix Polygoni Multiflori 8 parts, Herba Ainsliaeae ovovatae 5 parts, Folium Nerviliae fordii 17 parts, Herba Eleocharitis 12 parts, Herba Dianthi 4 parts, Radix Coicis 20 parts, Pericarpium Lagenariae sicerariae 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, Spora Lygodii 2 parts, Radix Sanguisorbae 7 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 15 parts, Radix Cyathulae 3 parts, Rhizoma Curcumae 13 parts, Ramulus Cinnamomi 3 parts, Cortex Moutan 3 parts, Semen Plantaginis 5 parts, Radix securidacae 10 parts, Rhizoma Polygoni Cuspidati 13 parts, 3 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 13 parts, Semen Abutili 11 parts, Radix Polygoni Multiflori 4 parts, Herba Ainsliaeae ovovatae 6 parts, Folium Nerviliae fordii 13 parts, Herba Eleocharitis 7 parts, Herba Dianthi 5 parts, Radix Coicis 18 parts, Pericarpium Lagenariae sicerariae 11 parts, Endothelium Corneum Gigeriae Galli 9 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 6 parts, Asteriscus Pseudosciaenae 12 parts, Folium Pyrrosiae 13 parts, Radix Cyathulae 4 parts, Rhizoma Curcumae 9 parts, Ramulus Cinnamomi 4 parts, Cortex Moutan 2 parts, Semen Plantaginis 6 parts, Radix securidacae 6 parts, Rhizoma Polygoni Cuspidati 14 parts, 5 parts, Radix Glycyrrhizae.

6. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 17 parts, Semen Abutili 15 parts, Radix Polygoni Multiflori 7 parts, Herba Ainsliaeae ovovatae 11 parts, Folium Nerviliae fordii 16 parts, Herba Eleocharitis 8 parts, Herba Dianthi 8 parts, Radix Coicis 16 parts, Pericarpium Lagenariae sicerariae 14 parts, Endothelium Corneum Gigeriae Galli 11 parts, Spora Lygodii 3 parts, Radix Sanguisorbae 5 parts, Asteriscus Pseudosciaenae 13 parts, Folium Pyrrosiae 14 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 12 parts, Ramulus Cinnamomi 3 parts, Cortex Moutan 1 part, Semen Plantaginis 10 parts, Radix securidacae 9 parts, Rhizoma Polygoni Cuspidati 13 parts, 7 parts, Radix Glycyrrhizae.

7. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 15 parts, Semen Abutili 12 parts, Radix Polygoni Multiflori 5 parts, Herba Ainsliaeae ovovatae 9 parts, Folium Nerviliae fordii 15 parts, Herba Eleocharitis 9 parts, Herba Dianthi 7 parts, Radix Coicis 19 parts, Pericarpium Lagenariae sicerariae 13 parts, Endothelium Corneum Gigeriae Galli 10 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 4 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 11 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 10 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 3 parts, Semen Plantaginis 8 parts, Radix securidacae 8 parts, Rhizoma Polygoni Cuspidati 14 parts, 9 parts, Radix Glycyrrhizae.

8. the Chinese medicine composition of control urinary system calculus according to claim 2, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Herba Lysimachiae 19 parts, Semen Abutili 14 parts, Radix Polygoni Multiflori 6 parts, Herba Ainsliaeae ovovatae 7 parts, Folium Nerviliae fordii 14 parts, Herba Eleocharitis 9 parts, Herba Dianthi 6 parts, Radix Coicis 17 parts, Pericarpium Lagenariae sicerariae 13 parts, Endothelium Corneum Gigeriae Galli 10 parts, Spora Lygodii 4 parts, Radix Sanguisorbae 4 parts, Asteriscus Pseudosciaenae 11 parts, Folium Pyrrosiae 11 parts, Radix Cyathulae 5 parts, Rhizoma Curcumae 10 parts, Ramulus Cinnamomi 5 parts, Cortex Moutan 3 parts, Semen Plantaginis 8 parts, Radix securidacae 8 parts, Rhizoma Polygoni Cuspidati 14 parts, 4 parts, Radix Glycyrrhizae.

9., according to the Chinese medicine composition of the arbitrary described control urinary system calculus of claim 3-8, it is characterized in that, described Chinese medicine composition is prepared by the following method:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of claim 3-8 is got, first time decocts the 10-15 water boiling and extraction doubly adding medical material gross weight, decocts 1-2 hour, leaches medicinal liquid stand-by: second time adds the water of 8-12 times amount, decoct 1-1.2h, leach medicinal liquid stand-by; Add the water of 8-12 times amount for the third time, decoct 0.8-1.2h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; The filtrate relative density be concentrated into 60 DEG C time is 1-1.2; Centrifugal under the rotating speed of 3000r/min; At 60 DEG C of-80 DEG C of spraying dry, obtain dry extract;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of Chinese medicine composition in control urinary system calculus medicine of the control urinary system calculus as described in as arbitrary in claim 1-9.