CN113876849A

CN113876849A - Traditional Chinese medicine composition for removing calculus and preparation process thereof

Info

Publication number: CN113876849A
Application number: CN202111322478.2A
Authority: CN
Inventors: 张兴东
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-11-09
Filing date: 2021-11-09
Publication date: 2022-01-04

Abstract

The invention provides a traditional Chinese medicine composition for removing calculus and a preparation process thereof, relating to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for removing calculus comprises the following components in parts by weight: herba Lysimachiae Christinae, spora Lygodii, folium Pyrrosiae, pulvis Talci, endothelium corneum Gigeriae Galli, caulis Sargentodoxae, Notoginseng radix and pericarpium Citri Reticulatae viride. The traditional Chinese medicine composition for removing calculus has a good effect of treating kidney calculus, is small in side effect, and has a good calculus removing effect on large-particle calculus. In addition, the invention also provides a preparation process of the fossil-dissolving traditional Chinese medicine composition, the raw materials are crushed into powder which can be directly drunk, and the prepared fossil-dissolving traditional Chinese medicine composition is easy to take. In addition, the invention also provides a preparation process of the fossil traditional Chinese medicine composition, which can realize the industrial preparation and production of the fossil traditional Chinese medicine composition, so that the raw material extraction efficiency is higher, and the produced fossil traditional Chinese medicine composition has better effect of treating kidney stones.

Description

Traditional Chinese medicine composition for removing calculus and preparation process thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for removing calculus and a preparation process thereof.

Background

Calculus is a solid mass formed in the lumen of a catheter or in the lumen of a luminal organ (e.g., kidney, ureter, gallbladder, or bladder, etc.) in a human or animal body. It is mainly found in gallbladder, bladder and renal pelvis, and also in pancreatic duct, salivary duct, etc. Calculus is composed of inorganic salts or organic substances. The stone generally has a core consisting of exfoliated epithelial cells, bacterial mass, parasite eggs or bodies, fecal mass or foreign matter, and inorganic salts or organic matter deposited layer by layer on the core. The mechanism of calculus formation is different in composition, shape, texture, and influence on the body, etc. depending on the organs involved. In general, calculus can cause obstruction of the lumen, affecting the drainage of fluid from the affected organ, causing symptoms such as pain, bleeding or secondary infection. Among them, kidney stones are caused by abnormal accumulation of crystalline substances (such as calcium, oxalic acid, uric acid, cystine, etc.) in the kidney, and are common and frequently encountered diseases of the urinary system. The traditional Chinese medicine for treating kidney stones is slow in curative effect, and the traditional Chinese medicine is poor in curative effect on stones with large particles.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for dissolving calculus, which has a good effect of treating kidney stone, has small side effect and also has a good calculus removing effect on large-particle calculus.

The invention also aims to provide a preparation process of the fossil-dissolving traditional Chinese medicine composition, which is simple in preparation process and easy to take.

The invention also aims to provide a preparation process of the fossil traditional Chinese medicine composition, which can realize industrial preparation and production of the fossil traditional Chinese medicine composition, so that the raw material extraction efficiency is higher, and the produced fossil traditional Chinese medicine composition has better effect of treating kidney stones.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a traditional Chinese medicine composition for removing calculus, which comprises the following components in parts by weight:

3-15 parts of longhairy antenoron herb, 5-15 parts of Japanese climbing fern spore, 3-15 parts of pyrrosia lingua, 3-10 parts of talcum powder, 5-15 parts of endothelium corneum gigeriae galli, 3-10 parts of degelatinized rattan, 3-10 parts of pseudo-ginseng and 3-10 parts of green tangerine peel.

In some embodiments of the present invention, one or more of cogongrass rhizome 3-15 parts, dandelion root 3-10 parts and sanguisorba officinalis 3-15 parts are further included.

In some embodiments of the present invention, one or more of 3-15 parts of polygonatum odoratum and 3-15 parts of achyranthes bidentata are further included.

In some embodiments of the invention, the composition further comprises 5-15 parts of psyllium.

In some embodiments of the invention, the ginseng also comprises 3-15 parts of ginseng.

On the other hand, the embodiment of the application provides a preparation process for preparing a stone-removing traditional Chinese medicine composition, which comprises the following steps:

weighing raw materials, drying, crushing the raw materials to 200-mesh and 300-mesh after drying, and preparing the powder.

In another aspect, an embodiment of the present application provides a manufacturing process of a traditional Chinese medicine composition for removing urinary calculus, which includes the following steps:

pulverizing the raw materials to 100-140 meshes, percolating in ethanol solution for 4-5 h to obtain percolate and residue, concentrating the percolate, mixing with filler, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition.

In some embodiments of the invention, the percolate is concentrated by a factor of 10 to 20.

In some embodiments of the invention, the ratio of the concentrated percolate to the filler is 1 (0.3-0.5) mg/L.

In some embodiments of the invention, the composition is formulated as a pill, tablet, granule, or capsule.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention provides a traditional Chinese medicine composition for removing calculus, which mainly comprises the following components in parts by weight: 3-15 parts of longhairy antenoron herb, 5-15 parts of Japanese climbing fern spore, 3-15 parts of pyrrosia lingua, 3-10 parts of talcum powder, 5-15 parts of endothelium corneum gigeriae galli, 3-10 parts of degelatinized rattan, 3-10 parts of pseudo-ginseng and 3-10 parts of green tangerine peel. In the composition, herba Lysimachiae Christinae can affect calculus structure, promote calculus dissolution and shrinkage, and enhance smooth muscle movement, increase ureter peristalsis frequency, and accelerate calculus removal. The polysaccharide component in the desmodium has definite inhibition effect on the crystallization of calcium aquatic oxalate which is the main component of the calculus, and the inhibition effect is enhanced along with the increase of the concentration, so that the growth rate of the calcium aquatic oxalate is slowed down, and the calculus growth is inhibited. The polysaccharide component in the alcohol insoluble substance of the desmodium has an inhibiting effect on the crystal growth of the calcium monohydrochloride; when seed crystals are not added, the polysaccharide part of the lysimachia christinae hance can delay the nucleation of the calcium monohydrochloride, namely the induction period of crystallization is prolonged, and the action valence of the polysaccharide extracted by 1.94 multiplied by 10 < -5 > g crude drug per ml is equivalent to the inhibition effect of normal human urine on the growth of the calcium monohydrochloride crystals. The smooth muscle tension of the ureter is correspondingly increased along with the increase of the using amount of the desmodium, and the diuretic and calculus-removing effects of the desmodium are obviously improved. The organic molecules in the lygodium japonicum extraction can inhibit the conversion of metastable calcium oxalate crystal COD to COM with more stable thermodynamics, and the size of the COD crystal is reduced along with the increase of the concentration of the lygodium japonicum extraction liquid, so that the formation of calcium oxalate calculus is favorably prevented. The pyrrosia lingua has a good effect of improving kidney stones; the medicine has the same effect as western medicine potassium citrate, can achieve the aim of treating the calculus by increasing the excretion of calcium oxalate crystals in urine, and also has the effect of relieving kidney injury. The pulvis Talci is prepared from pulvis Talci, and has diuretic effect. Talcum powder has adsorption and astringent effects, and can protect intestinal wall when administered orally. The pulvis Talci can protect wound surface, absorb secretion, and promote scabbing. Therefore, talcum powder belongs to the diuretic stranguria-treating medicine classified under the diuretic dampness-excreting medicine, and can play a role in inducing diuresis and removing urinary calculus. The herba lysimachiae, the lygodium japonicum, the pyrrosia lingua and the talcum powder are matched to be used as monarch drugs, wherein the herba lysimachiae, the lygodium japonicum and the pyrrosia lingua can play a role in increasing excretion of calcium oxalate crystals in urine and have a good effect on treating and preventing calculi, and the talcum powder and other drugs in the monarch drugs play a role in promoting urination and excretion and increasing calculi excretion probability.

In addition, the endothelium corneum Gigeriae Galli contains a special component of polyphenol alkaloid, and minerals can be disintegrated by alkalization reaction when contacting with it. Meanwhile, the endothelium corneum gigeriae galli can inhibit the formation of urinary calculus or dissolve calculus by increasing the excretion of elements such as strontium in the body. The endothelium corneum Gigeriae Galli extract is rich in multiple trace elements, and has effects of inhibiting calculus growth node, inhibiting enzyme activity, changing urine environment to inhibit urinary calculus, and dissolving formed calculus, so that endothelium corneum Gigeriae Galli has effects of removing calculus and promoting lithagogue. The Sargentodoxa cuneata is root of a dicotyledonous plant drug, namely, Chinese honeylocust vine of Asclepiadaceae, and has an excellent fossil function. The endothelium corneum Gigeriae Galli and caulis Sargentodoxae can be used as ministerial drugs to achieve excellent calculus dissolving effect, and can differentiate larger calculus into small calculus particles to discharge calculus. Because the components of the calculus are different, the shape of part of calculus is irregular, the texture is hard, and the traditional Chinese medicine is only used for dissolving and breaking the calculus difficultly, the monarch drug can play a certain calculus removing effect, but only has a good effect on a small particle structure, and the calculus effect on larger particles is not good enough. The endothelium corneum gigeriae galli and the herba cistanches are matched with the monarch drug as ministerial drugs, so that the calculus removing effect can be greatly enhanced, and the composition also has a strong calculus removing effect on large-particle calculus.

The Notoginseng radix contains Notoginseng radix total saponin component, and the Notoginseng radix total saponin has effects of promoting blood circulation, relieving inflammation and pain, dredging collaterals and activating collaterals, inhibiting blood platelet aggregation and increasing cerebrovascular flow. The Panax notoginsenosides have antiinflammatory effect on renal calculus patients. In addition, the panax notoginseng saponins are also an opioid peptide receptor stimulant, have certain analgesic effect on pain caused by thermal stimulation and chemicals, and have no addiction. Therefore, the pseudo-ginseng can be used as an adjuvant drug in the treatment of the calculus to play a role in stopping bleeding and relieving pain, and the pain of a calculus patient caused by calculus blockage can be relieved.

The green tangerine peel has the advantages that the temperature of the green tangerine peel can obviously increase the bile discharge of a patient and can relax the smoothness of an in-vitro gallbladder of the patient to resist the gallbladder contraction caused by the carbachol. Pericarpium Citri Reticulatae viride has strong choleretic effect on patients with calculus, and can promote bile secretion, increase bile amount, and protect liver cell function. In the theory of traditional Chinese medicine, the pericarpium citri reticulatae viride relieves liver qi stagnation, makes liver qi ascend, and has the effects of protecting liver and benefiting gallbladder as an adjuvant drug. The pericarpium citri reticulatae viride is used as an adjuvant drug to be matched with the monarch drugs, so that adverse effects on liver and gallbladder caused by the monarch drugs can be eliminated.

Therefore, the calculus-dissolving traditional Chinese medicine composition has a good effect of treating kidney stones, and also has a good calculus-removing effect on large-particle stones.

The invention also provides a preparation process of the stone-removing traditional Chinese medicine composition, which comprises the following steps: weighing raw materials, drying, crushing the raw materials to 200-mesh and 300-mesh after drying, and preparing the powder. The process can directly drink the raw materials by pulverizing into powder, and the preparation method is simple and the prepared calculus-removing Chinese medicinal composition is easy to take.

The invention also provides a preparation process of the stone-removing traditional Chinese medicine composition, which comprises the following steps: pulverizing the raw materials to 100-140 meshes, percolating in ethanol solution for 4-5 h to obtain percolate and residue, concentrating the percolate, mixing with filler, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. The process can realize the industrial preparation and production of the calculus-dissolving traditional Chinese medicine composition, so that the raw material extraction efficiency is higher, and the produced calculus-dissolving traditional Chinese medicine composition has a better effect of treating kidney stones.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

The invention provides a traditional Chinese medicine composition for removing calculus, which mainly comprises the following components in parts by weight: 3-15 parts of longhairy antenoron herb, 5-15 parts of Japanese climbing fern spore, 3-15 parts of pyrrosia lingua, 3-10 parts of talcum powder, 5-15 parts of endothelium corneum gigeriae galli, 3-10 parts of degelatinized rattan, 3-10 parts of pseudo-ginseng and 3-10 parts of green tangerine peel. The composition has a bitter, sour and slightly cold taste. It enters liver, gallbladder, kidney and bladder meridians. Has the functions of clearing away heat and toxic material, promoting urination, removing urinary calculus, promoting blood circulation and dissipating blood stasis. Can be used for treating liver calculus, cholelithiasis, cholecystitis, icterohepatitis, urinary calculus, edema, traumatic injury, venomous snake bite, and muscarinic poisoning. Herba Lysimachiae Christinae can affect calculus structure, promote calculus dissolution and shrinkage, and enhance smooth muscle movement, increase ureteral peristalsis frequency, and accelerate calculus removal. The polysaccharide component in the desmodium has definite inhibition effect on the crystallization of the main component calcium oxalate of the calculus, and the inhibition effect is enhanced along with the increase of the concentration, so that the growth rate of the calcium oxalate is slowed down, and the calculus growth is inhibited. The polysaccharide component in the alcohol insoluble substance of the desmodium has an inhibiting effect on the crystal growth of the calcium monohydrochloride; when seed crystals are not added, the polysaccharide part of the lysimachia christinae hance can delay the nucleation of the calcium monohydrochloride, namely the induction period of crystallization is prolonged, and the action valence of the polysaccharide extracted by 1.94 multiplied by 10 < -5 > g crude drug per ml is equivalent to the inhibition effect of normal human urine on the growth of the calcium monohydrochloride crystals. The smooth muscle tension of the ureter is correspondingly increased along with the increase of the using amount of the desmodium, and the diuretic and calculus-removing effects of the desmodium are obviously improved. The herba Lysimachiae Christinae has low toxicity and less adverse effects. The whole grass, mature spores, roots and rhizomes of the lygodium japonicum can be used as medicines, has cold property and sweet taste, has the effects of clearing heat and removing toxicity, inducing diuresis for treating stranguria, and inducing diuresis for removing edema, and is clinically used for treating urinary tract infection, whitish and turbid leucorrhea, damp-heat jaundice, nephritic edema, sore throat, mumps, enteritis, dysentery, skin eczema, herpes zoster and the like. Organic molecules in the lygodium japonicum extracting solution can inhibit the conversion of metastable calcium oxalate crystal COD to COM with more stable thermodynamics, and along with the increase of the concentration of the lygodium japonicum extracting solution, the size of the COD crystal is reduced along with the increase of the concentration of the lygodium japonicum extracting solution, thereby being beneficial to preventing the formation of calcium oxalate calculus. The folium Pyrrosiae has effects of promoting diuresis, relieving stranguria, clearing lung-heat and clearing heat, and can be used for treating stranguria, hematuria, lithangiuria, nephritis, metrorrhagia, lung heat cough and asthma, chronic tracheitis, incised wound, carbuncle, cellulitis, etc. The pyrrosia lingua has a good effect of improving kidney stones; the medicine has the same effect as western medicine potassium citrate, can achieve the aim of treating the calculus by increasing the excretion of calcium oxalate crystals in urine, and also has the effect of relieving kidney injury. The talcum powder has the effects of treating fever, catharsis, female milk difficulty, urine retention, diuresis, cold and heat accumulation in stomach and essence and qi benefiting. Talc powder consists of talc. Has effects of inducing diuresis for treating stranguria, clearing away summer-heat, eliminating dampness and healing sore. Talcum powder has adsorption and astringent effects, and can protect intestinal wall when administered orally. The pulvis Talci can protect wound surface, absorb secretion, and promote scabbing. Talcum powder has effects of promoting diuresis, treating stranguria, clearing away summer-heat, eliminating dampness, and healing sore. It belongs to the diuretic stranguria-treating medicine classified under the diuresis-inducing and dampness-excreting herbs, so it can induce diuresis and remove urinary calculus. The herba lysimachiae, the lygodium japonicum, the pyrrosia lingua and the talcum powder are matched to be used as monarch drugs, wherein the herba lysimachiae, the lygodium japonicum and the pyrrosia lingua can play a role in increasing excretion of calcium oxalate crystals in urine and have a good effect on treating and preventing calculi, and the talcum powder and other drugs in the monarch drugs play a role in promoting urination and excretion and increasing calculi excretion probability.

In addition, the endothelium corneum gigeriae galli has the effects of invigorating the stomach, promoting digestion, arresting seminal emission, stopping enuresis, treating stranguria and dissolving calculus. The endothelium corneum Gigeriae Galli contains a special component of polyphenol alkaloid, and mineral can be disintegrated by alkalization reaction when contacting with it. Meanwhile, the endothelium corneum gigeriae galli can inhibit the formation of urinary calculus or dissolve calculus by increasing the excretion of elements such as strontium in the body. The endothelium corneum Gigeriae Galli extract is rich in multiple trace elements, and has effects of inhibiting calculus growth node, inhibiting enzyme activity, changing urine environment to inhibit urinary calculus, and dissolving formed calculus, so that endothelium corneum Gigeriae Galli has effects of removing calculus and promoting lithagogue. The Sargentodoxa cuneata is root of a dicotyledonous plant drug, namely, Chinese honeylocust vine of Asclepiadaceae, and has an excellent fossil function. The endothelium corneum Gigeriae Galli and caulis Sargentodoxae can be used as ministerial drugs to achieve excellent calculus dissolving effect, and can differentiate larger calculus into small calculus particles to discharge calculus. Because the components of the calculus are different, the shape of part of calculus is irregular, the texture is hard, and the traditional Chinese medicine is only used for dissolving and breaking the calculus difficultly, the monarch drug can play a certain calculus removing effect, but only has a good effect on a small particle structure, and the calculus effect on larger particles is not good enough. The endothelium corneum gigeriae galli and the herba cistanches are matched with the monarch drug as ministerial drugs, so that the calculus removing effect can be greatly enhanced, and the composition also has a strong calculus removing effect on large-particle calculus.

The Notoginseng radix contains Notoginseng radix total saponin which is effective active substance extracted from Notoginseng radix root, and contains ginsenoside and notoginsenoside as main ingredients. The Panax notoginsenosides have effects in promoting blood circulation, relieving inflammation and pain, dredging collaterals, activating collaterals, inhibiting platelet aggregation, and increasing cerebrovascular flow. The Panax notoginsenosides can significantly inhibit inflammation caused by various inflammation-causing agents such as carrageenan and croton oil, and has antiinflammatory effect on nephrolithiasis, and can inhibit inflammation such as capillary permeability increase, inflammatory exudation and tissue edema caused by acute inflammation. In addition, the panax notoginseng saponins are also an opioid peptide receptor stimulant, have certain analgesic effect on pain caused by thermal stimulation and chemicals, and have no addiction. Therefore, the pseudo-ginseng can be used as an adjuvant drug in the treatment of the calculus to play the effects of stopping bleeding and relieving pain, and the pain of a calculus patient can be relieved.

The above-mentioned Qing Pi is warm in nature and bitter and pungent in flavor. Belongs to qi-regulating medicines, and belongs to the liver channel, gallbladder channel and stomach channel, and has the efficacies of soothing liver, breaking qi, removing food retention and resolving stagnation. The green tangerine orange peel can obviously increase the bile discharge of a patient and relax the smoothness of the isolated gallbladder of the patient to resist the gallbladder contraction caused by the bethanechol. Pericarpium Citri Reticulatae viride has strong choleretic effect on patients with calculus, and can promote bile secretion, increase bile amount, and protect liver cell function. In the theory of traditional Chinese medicine, the pericarpium citri reticulatae viride relieves liver qi stagnation, makes liver qi ascend, and has the effects of protecting liver and benefiting gallbladder as an adjuvant drug. The pericarpium citri reticulatae viride is used as an adjuvant drug to be matched with the monarch drug, so that adverse effects on liver and gallbladder caused by the monarch drug can be eliminated.

In the invention, the composition also comprises one or more of 3-15 parts of cogongrass rhizome, 3-10 parts of dandelion root and 3-15 parts of garden burnet root. The antibacterial active ingredients in the dandelion mainly comprise polysaccharides, flavonoids and phenolic acids, the substances can inhibit bacteria and avoid infection, when a patient has large calculus, calculus damage is often easily caused to the patient, infection is easily bred, and the dandelion can play a good antibacterial role and avoid infection. The herba Taraxaci is used as adjuvant for directly treating secondary concurrent syndrome. The sanguisorba officinalis is a rosaceous plant, is used as a medicine by dry roots, is slightly cold in nature, bitter, astringent and sour in taste, enters liver and large intestine channels, and has the effects of cooling blood and stopping bleeding, clearing heat and removing toxicity, reducing swelling and healing sore and the like. Modern chemical component researches show that sanguisorba contains more tannin components including sanguisorbain, ellagic acid, gallic acid, catechin and the like, and also contains unique components of sanguisorbin I, sanguisorbin II and the like. Sanguisorba root has the effects of nourishing yin and stopping bleeding, can play a role in qi and blood for patients with calculi, and can enhance the property by being matched with pseudo-ginseng. In addition, due to the anti-inflammatory effect of the garden burnet, the garden burnet and the dandelion are combined together, so that the anti-inflammatory capability can be further enhanced, and the problem that a stone patient is inflamed at a stone position is solved. The radix Sangusorbae also has diuretic effect, and can be used together with above principal drugs to discharge calculus through urinary tract. The lalang grass rhizome is dried rhizome of Imperata cylindrica of Gramineae. It enters lung, stomach and bladder channels, has effects of clearing heat, promoting fluid production, promoting diuresis, treating stranguria, cooling blood, and stopping bleeding, and is mainly used for treating fatigue deficiency, edema oliguria, damp-heat jaundice, lung heat cough, warm heat polydipsia, heat stranguria with pain, hematemesis, hemorrhage, eczema, and toxic swelling. The active ingredients in the cogongrass rhizome comprise: saccharides mainly including polysaccharide, glucose, fructose, sucrose, xylose, etc.; triterpenes mainly include arundoin, imperatorin, ferenol, arborinane, etc.; organic acids mainly including chlorogenic acid, vanillic acid, palmitic acid, p-hydroxycinnamic acid, caffeic acid, etc.; flavones mainly comprising 4, 7-dimethoxy, 5-methylcoumarin, daucosterol, bifendate and the like; sterols including sitosterol and luteolin, and the like; lactones including anemonin and coixol; is rich in metal elements such as K, Fe, Cu, Zn, Mn, Ca, Mg and the like. Wherein, the saccharides are the main active components of the cogongrass rhizome, the content of the saccharides reaches more than 80 percent of the total extract, and the main pharmacological action is to adjust the immunologic function of the organism, which is one of the pharmacological action bases of the cogongrass rhizome, namely, the principal deficiency of labor and injury, and the strengthening of the middle-jiao and replenishing qi. The triterpenes have antitumor, antiinflammatory, and antibacterial effects. Chlorogenic acid and caffeic acid have hemostatic effects, and are the main effective components for treating various hemorrhagic diseases. In addition, flavonoids extracted from lalang grass rhizome have pharmacological effects of resisting inflammation, inhibiting bacteria, regulating immunity, etc. In addition, the abundant Mg element causes the increase of serum magnesium, and the increased Mg ions compete with Ca ions in vivo to combine with oxalate ions to form more magnesium oxalate which is discharged out of the body through urine, thereby inhibiting the growth and aggregation of calcium oxalate crystals. The lalang grass rhizome also has effects of tranquilizing, relieving fever and relieving pain; the radix Sangusorbae and herba Taraxaci also have analgesic effect. The lalang grass rhizome, dandelion root and sanguisorba officinalis have the effects of resisting inflammation and inhibiting bacteria, and can be matched with monarch drug to relieve the inflammation and infection risk of patients. Meanwhile, the pain relieving effects of the cogongrass rhizome, the dandelion root and the garden burnet root can greatly relieve renal colic when a patient with calculus suffers from the disease, and relieve the pain of the patient.

In the invention, the composition also comprises one or more of 3-15 parts of polygonatum and 3-15 parts of achyranthes. The rhizoma Polygonati Odorati can be used for treating yin injury of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat. The polysaccharide in the polygonatum odoratum can stimulate bladder peristalsis, so that the patient with calculus is easy to urinate, and the diuretic effect is achieved. The polygonatum is used as a messenger drug to be matched with a monarch drug, namely longhairy antenoron herb, talcum powder and a ministerial drug, namely sanguisorba, so that the polygonatum can play a middle harmonizing role and also has a good treatment effect on ureteral calculus. The achyranthes root, radix achyranthis bidentatae, bitter, sweet and sour, is neutral and enters liver and kidney meridians. It has effects in dispelling blood stasis, dredging channels, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria, and promoting blood circulation. The achyranthes root is used as a ministerial drug and matched with a monarch drug, leads the monarch drug to descend, promotes kidney peristalsis and can enhance the effect of removing urinary calculus. In addition, the achyranthes root also has the pharmacological actions of resisting bacteria and viruses, easing pain and resisting inflammation, and the effect of easing pain and resisting inflammation for the patient with calculi can be further improved by matching with one or more of the lalang grass rhizome, the dandelion root and the garden burnet root, so that the patient with calculi can relieve pain in time, and the pain of the patient is relieved.

In the invention, the composition also comprises 5-15 parts of plantain seeds. The semen plantaginis can be used for treating stranguria due to heat-evil, pain, edema, diarrhea, conjunctival congestion, swelling and pain, and cough due to phlegm heat. The semen plantaginis has a strong diuretic function, can promote the discharge of calculus, is matched with the monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs to play a middle harmonizing role, has a good effect of promoting the discharge of calculus discharged from urinary tract, and can further improve the calculus discharging effect.

In the invention, the composition also comprises 3-15 parts of ginseng. The radix codonopsis pilosulae is used for treating lumbago due to kidney deficiency, spermatorrhea and impotence, has the effect of tonifying the kidney, and has a good treatment effect on the kidney deficiency caused by calculus of a patient.

The invention also provides a preparation process of the stone-removing traditional Chinese medicine composition, which comprises the following steps: weighing raw materials, drying, crushing the raw materials to 200-mesh and 300-mesh after drying, and preparing the powder. The raw materials are directly dried and then directly crushed into 200-mesh and 300-mesh powder, the powder is prepared, the preparation process is simple, the powder can be directly drunk, and the administration is easy.

The invention also provides a preparation process of the stone-removing traditional Chinese medicine composition, which comprises the following steps: pulverizing the raw materials to 100-140 meshes, percolating in ethanol solution for 4-5 h to obtain percolate and residue, concentrating the percolate, mixing with filler, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. After the raw materials are crushed to 100-140 meshes, the seepage and percolation effects of the raw materials in ethanol can be effectively improved, and the extraction effect is better. Meanwhile, the raw materials crushed to 100-140 meshes are more convenient for the subsequent processes of further pelleting, tabletting, capsule making and the like, and have lower difficulty and stronger applicability. After being crushed, the raw material is soaked in ethanol with the concentration of 45 vol% -60 vol%, so that the ethanol can quickly penetrate through the surface layer of the raw material, and the internal effective components can quickly penetrate into an ethanol solvent, thereby achieving the effect of improving the extraction efficiency. In the invention, the concentration of the ethanol ensures that the effects of the infiltration and the percolation are better, and simultaneously, the cost investment of the ethanol can be effectively reduced. In addition, after percolation, the ethanol can be recovered and used for the second time, so that the input cost of the ethanol can be reduced again, and the preparation cost and the performance-price ratio of the composition are lower. Therefore, the preparation process can realize the industrial preparation and production of the calculus-dissolving traditional Chinese medicine composition, so that the raw material extraction efficiency is higher, and the produced calculus-dissolving traditional Chinese medicine composition has a better effect of treating the kidney stone.

It should be noted that, in the invention, the percolation is carried out under the conditions that the temperature is 15-20 ℃ and the percolation pressure is 0.2-0.4 MPa, so that the effective components can be extracted from the raw materials to a greater extent in the percolation process, and the effect is better. When the temperature is higher, the entropy value of the ethanol solution is larger, the volatility of the ethanol is higher, the extraction is not facilitated, and when the temperature is lower, the percolation extraction is influenced, and the extraction efficiency is higher.

In the invention, the powder I is dried at the temperature of 55-60 ℃. The powder has the advantages of convenient storage and transportation, and is beneficial to the production of subsequent medicinal preparations and has high use value. Because the concentration of the effective components is higher after the colation is concentrated, the concentration of the effective components is reduced by adding the filler in the invention, the composition meets the taking standard of the medicine, simultaneously, the volume of the composition can be increased, the composition is convenient for patients to take and carry, and the condition that the medicine is lost due to small volume and inconvenient to take is prevented.

In the invention, the concentration multiple of the colation is 10-20 times. Percolating to obtain percolate and filter residue. Concentrating the percolate by 10-20 times, mixing with filler, and drying to obtain powder I. After the concentration is 10 to 20 times, the volume of the percolate can be effectively reduced, so that the percolate is more convenient to store, transport and use and has stronger practicability.

In the invention, the ratio of the concentrated percolate to the filler is 1 (0.3-0.5) mg/L. The volume of the active ingredients of the composition is proper at a certain time, so that the expected preparation effect is achieved

In the present invention, the composition is formulated into a pill, tablet, granule or capsule, thereby making the composition more applicable.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment aims to provide a traditional Chinese medicine composition for removing calculus, which comprises the following raw materials:

3g of longhairy antenoron herb, 5g of climbing fern spore, 3g of pyrrosia lingua, 3g of talcum powder, 5g of chicken's gizzard-membrane, 3g of degelatinized Sargent gloryvine stem, 3g of pseudo-ginseng, 3g of green tangerine peel, 3g of cogongrass rhizome, 3g of dandelion root, 3g of garden burnet root, 3g of polygonatum odoratum, 3g of achyranthes root, 5g of plantain seed and 3g of radix codonopsis pilosulae.

The preparation method of the composition comprises the following steps: crushing the raw materials to 100 meshes, percolating in an ethanol solution for 4 hours to obtain a percolate and filter residues, concentrating the percolate by 10 times, mixing the percolate with a filler according to the material-liquid ratio of 1:0.3mg/L, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. Finally, the obtained composition is prepared into granules.

Example 2

6g of longhairy antenoron herb, 7g of climbing fern spore, 6g of pyrrosia lingua, 4g of talcum powder, 7g of chicken's gizzard-membrane, 4g of degelatinized Sargent gloryvine stem, 4g of pseudo-ginseng, 4g of green tangerine peel, 6g of cogongrass rhizome, 4g of dandelion root, 6g of garden burnet root, 6g of polygonatum odoratum, 6g of achyranthes root, 7g of plantain seed and 6g of radix codonopsis pilosulae.

The preparation method of the composition comprises the following steps: crushing the raw materials to 110 meshes, percolating in an ethanol solution for 4.2h to obtain a percolate and filter residues, concentrating the percolate by 12 times, mixing the percolate with a filler according to the material-liquid ratio of 1:0.35mg/L, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. Finally, the obtained composition is prepared into granules.

Example 3

9g of longhairy antenoron herb, 10g of climbing fern spore, 9g of pyrrosia lingua, 6g of talcum powder, 10g of chicken's gizzard-membrane, 6g of degelatinized Sargent gloryvine stem, 6g of pseudo-ginseng, 6g of green tangerine peel, 9g of cogongrass rhizome, 6g of dandelion root, 9g of garden burnet root, 9g of polygonatum odoratum, 9g of achyranthes root, 10g of plantain seed and 9g of radix codonopsis pilosulae.

The preparation method of the composition comprises the following steps: pulverizing the raw materials to 120 meshes, percolating in an ethanol solution for 4.5h to obtain a percolate and filter residues, concentrating the percolate by 15 times, mixing with a filler according to the material-liquid ratio of 1:0.4mg/L, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. Finally, the obtained composition is prepared into granules.

Example 4

12g of longhairy antenoron herb, 15g of climbing fern spore, 12g of pyrrosia lingua, 8g of talcum powder, 15g of chicken's gizzard-membrane, 8g of degelatinized Sargent gloryvine stem, 8g of pseudo-ginseng, 8g of green tangerine peel, 12g of cogongrass rhizome, 8g of dandelion root, 12g of garden burnet root, 12g of fragrant solomonseal rhizome, 12g of achyranthes root, 15g of plantain seed and 12g of double ginseng.

The preparation method of the composition comprises the following steps: crushing the raw materials to 130 meshes, percolating in an ethanol solution for 4.7h to obtain a percolate and filter residues, concentrating the percolate by 18 times, mixing the percolate with a filler according to the material-liquid ratio of 1:0.45mg/L, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. Finally, the obtained composition is prepared into granules.

Example 5

15g of longhairy antenoron herb, 15g of climbing fern spore, 15g of pyrrosia lingua, 10g of talcum powder, 15g of chicken's gizzard-membrane, 10g of degelatinized Sargent gloryvine stem, 10g of pseudo-ginseng, 10g of green tangerine peel, 15g of cogongrass rhizome, 10g of dandelion root, 15g of garden burnet root, 15g of fragrant solomonseal rhizome, 15g of achyranthes root, 15g of plantain seed and 15g of double ginseng.

The preparation method of the composition comprises the following steps: pulverizing the raw materials to 140 meshes, percolating in ethanol solution for 5h to obtain percolate and filter residue, concentrating the percolate by 10-20 times, mixing with filler at a ratio of 1:0.5mg/L, and drying to obtain powder I; grinding the filter residue, mixing with the gel matrix, and drying to obtain powder II; and mixing the powder I and the powder II, and sterilizing to obtain the composition. Finally, the obtained composition is prepared into granules.

Example 6

3g of longhairy antenoron herb, 5g of climbing fern spore, 3g of pyrrosia lingua, 3g of talcum powder, 5g of chicken's gizzard-membrane, 3g of degelatinized Sargent gloryvine stem, 3g of pseudo-ginseng, 3g of green tangerine peel, 3g of cogongrass rhizome, 3g of dandelion root, 3g of garden burnet root, 3g of radix polygonati officinalis, 5g of plantain seed and 3g of radix codonopsitis.

Example 7

3g of longhairy antenoron herb, 5g of climbing fern spore, 3g of pyrrosia lingua, 3g of talcum powder, 5g of chicken's gizzard-membrane, 3g of degelatinized Sargent gloryvine, 3g of pseudo-ginseng, 3g of green tangerine peel, 3g of cogongrass rhizome, 3g of fragrant solomonseal rhizome, 3g of twotooth achyranthes root, 5g of plantain seed and 3g of double ginseng

Example 8

The preparation method of the composition comprises the following steps: weighing raw materials, drying, pulverizing to 250 mesh, and making into powder.

Comparative example 1

Wulin Huashi pills produced by Gladan Dong pharmaceutical industry Co., Ltd, Qinghai province, were purchased as comparative example 1.

Experimental example 1

Healthy male SD rats 60 in age of 6 weeks, with SPF level and body mass (200 +/-20) g, are selected and fed for 1 week uniformly and adaptively for experiments. The experimental method is to establish a rat calculus model, and rats are randomly divided into 1-6 groups, and each group comprises 10 rats. Groups 1-3 as experimental drug groups, the particles prepared in examples 1, 3 and 5 (examples 1, 3 and 5 correspond to low dose, medium dose and high dose groups, respectively) were infused with cold boiled water 10ml, corresponding to groups 1-3, respectively, and rats were gavaged with suspension for continuous intervention 28 d; taking the 4 groups as a positive drug control group, selecting the Wulin Huashi pills in the comparative example 1, brewing the Wulin Huashi pills with cold boiled water by 10ml, and continuously intervening the rats 28d of the 4 groups by gastric lavage with suspension; using 5 groups as a control group, performing intragastric perfusion with distilled water with the same volume as the intragastric perfusion for 1 time/day, and continuously performing 28 days; and taking 6 groups as normal groups, performing intragastric perfusion with distilled water with the same volume as the normal groups, and performing intragastric perfusion for 1 time/day for 28 days continuously. In the above 1-6 groups, 1% of ethylene glycol and 2% of ammonium chloride were added to the rest groups except 6 groups, and the contents were poured into the stomach at a volume of 2 ml/time and 1/day. Urine was collected 1 day before the end of the experiment for 24h using a metabolic cage. Anesthetizing rats, taking blood from abdominal aorta, centrifugally separating serum, and detecting the contents of Ga ions, Mg ions, creatinine, urea nitrogen, urine calcium ions and magnesium ions in the serum of each group of rats. Taking out the left kidney immediately at low temperature, taking one half of kidney tissue for homogenate, centrifuging and taking supernatant, and measuring the contents of oxalic acid, SOD, MDA and protein in the supernatant. Another half of the kidney tissues were fixed with 10% formalin, the sections were stained and observed with a microscope, and the number of calcium oxalate crystals per high-magnification field was counted on average and classified: : the grade 0 is no calculus and crystal formation; grade 1 is a small amount of calculus and crystal formation, and each visual field has less than 3; grade 2 is more stones and crystals, and each visual field is 3-5; grade 3 is more stones and crystals, and each vision field is 6-10; grade 4 is the formation of a large number of stones and crystals, more than 10 stones and crystals form in each visual field, and even the stones and crystals form masses and block renal tubules. The 0-4 fractions were scored as 1, 2, 3, 4, and 5, respectively. And finally, applying statistical treatment, wherein the measured data are all expressed by mean plus minus standard deviation, the comparison of multiple groups of means adopts variance analysis, and the difference with P <0.05 has statistical significance. Finally, preparing a table 1 showing the influence of each group on the biochemical indexes of the serum of the rat with the kidney stone and the oxalic acid content of the kidney tissues; table 2. influence table of biochemical index of urine of rat with renal calculus; table 3. table of the influence of each group on oxidative stress indexes of kidney stone rats; table 4. influence of each group on kidney stone rat crystallization scores.

No animal death occurred during the experiment. Compared with 6 groups, 5 groups have higher content of serum calcium ions, creatinine, urea nitrogen and oxalic acid in kidney tissues, and lower content of serum magnesium ions (P < 0.01). The content of serum calcium ion, creatinine and renal tissue oxalic acid in the group 2 is obviously reduced compared with that in the group 5 (P is less than 0.05). The content of Ca2+, creatinine, urea nitrogen and oxalic acid in the kidney tissues of the 3 groups is obviously reduced compared with that of the 5 groups (P is less than 0.05 and P is less than 0.01); serum magnesium ion levels were increased (P <0.05 compared to group 5). There was no significant change in each index in group 1 (P >0.05 compared to group 5). The creatinine difference between the group 1 and the group 2 is statistically significant (P <0.01), and the urea nitrogen difference between the group 1 and the group 4 is statistically significant (P < 0.01). The remaining indicators were statistically not different from the 4 groups (P > 0.05). The results are shown in Table 1.

TABLE 1 table of the influence of each group on the biochemical indexes of the serum of the rat with renal calculus and the oxalic acid content of the renal tissue

Note: in comparison with the 6 sets of samples,^aP<0.01; in comparison with the 5 sets of data,^bP<0.05，^cP<0.01; in comparison with the 4 sets of data,^dP<0.01

the content of calcium ions in urine of 5 groups is increased and the content of magnesium ions is reduced (P <0.01) compared with 6 groups. The content of Ca2+ in urine of group 2 and group 3 is reduced compared with that of group 4 (P <0.05), and the content of magnesium ion in urine of group 3 is increased compared with that of group 5 (P < 0.01). Compared with 5 groups, 1 group has no obvious change of each index (P > 0.05). The indexes of the 1 group, the 2 group and the 3 group have no statistical significance compared with the indexes of the 4 groups (P is more than 0.05). The results are shown in Table 2.

TABLE 2. influence of each group on urine biochemical index of kidney stone rat

Group of	Calcium carbonate	Magnesium alloy
			1	2.75±0.39	1.85±0.23
2	2.40±0.54^b	1.97±0.19
			3	2.32±0.46^b	2.18±0.16^c
4	2.31±0.46^b	2.11±0.20^b
			5	3.03±0.49^a	1.80±0.30^a
6	2.10±0.50	2.42±0.21

Note: in comparison with the 6 sets of samples,^aP<0.01; in comparison with the 5 sets of data,^bP<0.05，^cP<0.01

compared with 6 groups, 5 groups of rats have reduced SOD content in kidney tissues and increased MDA content (P < 0.01). The MDA content of the groups 2 and 3 is reduced compared with that of the group 5 (P is less than 0.05, P is less than 0.01), and the SOD content of the group 3 is increased compared with that of the group 5 (P is less than 0.01). The indexes of 1 group, 2 groups and 3 groups have no obvious change (compared with 5 groups, P is more than 0.05). The differences between SOD and MDA in group 1 and group 4 are statistically significant (P < 0.05). The remaining indicators were statistically not different from the 4 groups (P > 0.05). The results are shown in Table 3.

TABLE 3 influence of groups on oxidative stress index of kidney stone rats

Group of	SOD(U/mg prot)	MDA(nnol/mg prot)
			1	136.85±34.23^d	3.88±0.60^d
2	158.29±20.56	3.28±0.42^b
			3	173.89±22.16^c	3.07±0.34^c
4	170.32±25.19^c	3.01±0.44^c
			5	129.20±23.21^a	4.19±0.70^a
6	205.58±32.27	2.21±0.38

Note: in comparison with the 6 sets of samples,^aP<0.01; in comparison with the 5 sets of data,^bP<0.05，^cP<0.01; in comparison with the 4 sets of data,^dP<0.05

the 5 groups of rats had significantly higher crystallization scores (P <0.01) compared to the 6 groups. The crystallization scores of the 2 groups and the 3 groups are reduced compared with the 5 groups (P <0.05, P < 0.01); there was no significant change in score for group 1 compared to group 5 (P > 0.05). The scores of 1 group, 2 group and 3 group are not statistically significant compared with the scores of 4 groups (P > 0.05). The results are shown in Table 4.

TABLE 4 influence of groups on kidney stone rat crystallization scores

and (4) conclusion: in the experiment, the contents of serum calcium ions and urine calcium ions of a kidney stone model rat induced by glycol are increased, the content of oxalic acid in kidney tissues is increased, calcium and oxalic acid can be combined into calcium oxalate with low solubility, and crystals are formed in the kidney and stones are gradually formed. At the same time, the serum creatinine and urea nitrogen content is obviously increased, which indicates that the renal function is damaged. The fossil traditional Chinese medicine composition can obviously reduce the contents of serum calcium ions, creatinine, urea nitrogen, urinary calcium ions and renal tissue oxalic acid of a rat with a renal calculus model, and reduce the formation of calcium oxalate crystals, and shows that the fossil traditional Chinese medicine composition has a treatment effect on ethylene glycol-induced calcium oxalate calculus, can protect renal tubular epithelial cells, recovers and maintains the functions of reabsorption of calcium ions in urine and the like, and has the function of protecting renal function.

Meanwhile, as shown by known research, the blood magnesium is an activator of a plurality of enzyme systems in cell metabolism, and magnesium ions can reduce the size of calcium oxalate and calcium phosphate crystals, the effect is concentration-dependent, and the higher the concentration of the magnesium ions, the smaller the crystals are. Magnesium ions can be combined with oxalate to generate magnesium-oxalate compound with higher solubility, thereby reducing the saturation of calcium oxalate in vivo and inhibiting the formation and aggregation of calcium oxalate crystals. The results of experimental example 1 show that the traditional Chinese medicine composition for treating calculus can obviously increase the contents of magnesium ions and urinary calcium ions in serum of a rat with a renal calculus model, has the effect of improving metabolic disturbance, and the increased magnesium ions compete with calcium ions in vivo to combine with oxalate ions to form more magnesium oxalate which is discharged out of the body through urine, so that the growth and aggregation of calcium oxalate crystals are inhibited.

The existing research shows that the excessive generation of free radicals and oxidative stress injury are important reasons for the occurrence of calcium oxalate calculus. Research shows that toxic reactions such as change of surface properties of cell membranes, interruption of mitochondrial functions, formation of active oxygen and the like can be generated when renal tubular epithelial cells are exposed to oxalic acid, high oxalic acid-induced high active oxygen level further causes redox imbalance and lipid peroxidation, renal inflammatory reaction, cell membrane integrity loss and renal epithelial tissue injury are caused, necrosis of small lumens and shedding of epithelial cells are caused, the shed epithelial cells provide crystallization nuclei for formation of crystals, a material basis is provided for heterogeneous nucleation, and in addition, exposed basal membranes provide sites for adhesion of crystals after renal tubular epithelial cells are necrotic and shed. MDA and SOD are good indicators for reflecting in vivo oxidation and antioxidant levels. The results of the experimental example 1 show that the 5 groups of rats have the kidney tissues with the reduced antioxidant enzyme SOD activity and the increased MDA content, which indicates that the kidney has oxidative stress injury and generates a large amount of active oxygen, thereby damaging the renal tubular epithelial cells and promoting the formation and precipitation of crystals. The fossil traditional Chinese medicine composition can obviously reduce the MDA content and improve the SOD content, and shows that the fossil traditional Chinese medicine composition can improve the oxidation resistance of organisms and remove free radicals, thereby protecting renal tubular epithelial cells, maintaining the normal structure and function of renal tubules and the effective filtering capacity of renal glomeruli, and free calcium oxalate crystals are not easy to adhere and aggregate to generate larger calculus, so that the calculus formation is reduced.

Therefore, the traditional Chinese medicine composition for removing calculus can obviously reduce the concentration of calcium ions, reduce the content of oxalic acid, reduce the content of serum creatinine and urea nitrogen, increase the concentration of magnesium ions, has obvious effects of resisting calculus and protecting renal functions, and reduces the formation and aggregation of calcium oxalate crystals and inhibits the formation of calculus by improving the oxidation resistance of an organism, removing free radicals and protecting renal tubular epithelial cells.

Effect example 1

Collecting 45 volunteers of patients with renal calculus, wherein each 5 volunteers are divided into 1-9 groups, and 1-7 groups of patients with renal calculus take the granules prepared in examples 1-7; the powder prepared in example 8 was administered to stone patients in 8 groups; the patients with calculus in 9 groups took the Wulin Huashi pills produced by Gladan Dong pharmaceutical Co Ltd of Qinghai province in comparative example 1. The dosage, administration time and administration frequency of the above 1-9 groups are the same, and the administration is continued for 1 month. The effect of 45 patients before and after taking the medicine is compared, and the change of calculus of the patients before and after taking the medicine is observed by means of B ultrasonic. (Note: the sizes of the renal calculus of the volunteers collected in the present effect example are all within the range of 3 mm-8 mm)

TABLE-nephrolithiasis patient taking experience test result table

As can be seen from the above table, after 1 month after 1-5 groups of the above groups of kidney stone volunteers took the granules prepared in examples 1-5, the average diameter of the stones was significantly reduced by B-ultrasonography, and the stones with an average diameter of 5.1mm or less were almost completely discharged, so that the patients were substantially cured. By comparing the group 1 with the group 6, the variable of the patients in the group 6 and the group 1 is the presence or absence of achyranthes root, and the difference value of the calculus diameters before and after the patients in the group 6 take the medicine is obviously smaller than that of the group 1, so that the calculus removing effect of the group 6 is lower than that of the group 1, and the achyranthes root is used for promoting the kidney peristalsis and has obvious effect of removing calculus. Compared with the group 1 and the group 7, the variable is that the group 7 lacks dandelion root and sanguisorba officinalis, the mean relieving satisfaction degree of the renal colic disease of the group 7 is obviously lower than that of the group 1 from the gram weight of the group 1 in the table, so that the analgesic effect can be enhanced and the renal colic can be relieved by simultaneously adding the lalang grass rhizome, the dandelion root and the sanguisorba officinalis in the components. Compared with the above 1 group and 8 groups, the variable is that the preparation processes adopted by the 8 groups are different, so that the phenomenon that the difference value of the diameters of the calculus before and after the calculus is taken by the patients of the 8 groups is lower than that of the 1 group, and the composition medicaments produced by the preparation process adopted by the 1 group are obviously better than those produced by the preparation process adopted by the 8 groups, and the preparation process adopted by the 1 group can effectively extract effective substances of the medicaments, so that the medicinal effect can be enhanced. The above 8 groups of the preparation processes are obviously simpler and suitable for non-industrial preparation, although the efficacy is reduced. Compared with the groups 1-8 and 9, the group 1-8 prepared by the embodiment of the invention has obviously better calculus removing effect, relieving satisfaction degree of renal colic disease and average satisfaction of no side effect after taking than the group 9. Therefore, compared with the fossil medicaments on the market, the traditional Chinese medicine composition for removing calculus, which is prepared by the invention, has the advantages of good effect of treating kidney calculus, small side effect and good effect of removing calculus of large-particle calculus.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for dissolving calculus is characterized by comprising the following components in parts by weight:

2. The fossil-dissolving traditional Chinese medicine composition according to claim 1, further comprising one or more of 3-15 parts of cogongrass rhizome, 3-10 parts of dandelion root and 3-15 parts of sanguisorba officinalis.

3. The fossil-dissolving traditional Chinese medicine composition according to claim 1, further comprising one or more of 3-15 parts of polygonatum odoratum and 3-15 parts of achyranthes bidentata.

4. The fossil-dissolving traditional Chinese medicine composition according to claim 1, further comprising 5-15 parts of semen plantaginis.

5. The fossil-dissolving traditional Chinese medicine composition according to claim 1, further comprising 3-15 parts of ginseng.

6. A manufacturing process for manufacturing the fossil traditional Chinese medicine composition according to any one of claims 1 to 5, comprising the steps of:

7. A manufacturing process for manufacturing the fossil traditional Chinese medicine composition according to any one of claims 1 to 5, comprising the steps of:

8. The process for preparing a fossil-containing Chinese medicinal composition according to claim 7, wherein the concentration of the percolate is 10-20 times.

9. The preparation process of the fossil traditional Chinese medicine composition according to claim 7, wherein a material-to-liquid ratio of the concentrated percolate to the filler is 1 (0.3-0.5) mg/L.

10. The process of making a fossil-providing traditional Chinese medicine composition of claim 7, wherein the composition is formulated as a pill, tablet, granule or capsule.